WELCOME TO ACTELION S AGM 2015
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1 WELCOME TO ACTELION S AGM May 2015 Copyright 2015 Actelion Pharmaceuticals Ltd
2 ACTELION S ANNUAL GENERAL MEETING 2015 MEETING STRUCTURE Opening Remarks Business Review 2014 Agenda & Proposals Jean-Pierre Garnier, Chairman of the Board Jean-Paul Clozel, Chief Executive Officer André Muller, Chief Financial Officer Jean-Pierre Garnier, Chairman of the Board Marian Borovsky, Secretary of the Board of Directors Actelion Pharmaceuticals Ltd 08 May 2015
3 FORMAL DECLARATIONS REGARDING THE CONSTITUTION OF THE MEETING Actelion Pharmaceuticals Ltd 08 May 2015
4 IHR epad / YOUR epad Ja Oui Yes Enthaltung Abstention Abstention Nein Non No Actelion Pharmaceuticals Ltd 08 May 2015
5 FORMAL DECLARATIONS REGARDING THE CONSTITUTION OF THE MEETING Actelion Pharmaceuticals Ltd 08 May 2015
6 OPENING REMARKS BY THE CHAIRMAN OF THE BOARD Jean-Pierre Garnier Actelion Pharmaceuticals Ltd 08 May 2015
7 ACTELION SHARE PRICE PERFORMANCE Selexipag results Share price development +53% in 2014 SNB announcement AGM 2014 ACTELION SWISS SMI Jan-14 Apr-14 Jul-14 Oct-14 Jan-15 Apr Actelion Pharmaceuticals Ltd 08 May 2015
8 DELIVERING ON OUR STRATEGY CREATES VALUE > CHF 1 BILLION RETURNED TO SHAREHOLDERS OVER 3 YEARS SHARE PRICE PERFORMANCE DIVIDEND PAYMENT Actelion Pharmaceuticals Ltd 08 May 2015
9 CONTINUED CASH RETURNED TO SHAREHOLDERS 2015 INITIATIVES New second-line share repurchase: up to 10 million shares within 3 years Increased dividend: Board proposal CHF 1.30 per share Actelion Pharmaceuticals Ltd 08 May 2015
10 OPENING REMARKS BY THE CHAIRMAN OF THE BOARD Jean-Pierre Garnier Actelion Pharmaceuticals Ltd 08 May 2015
11 OUTSTANDING PERFORMANCE IN 2014 Jean-Paul Clozel, CEO Actelion Pharmaceuticals Ltd 08 May 2015
12 OUR STRATEGIC PRIORITIES STAY THE SAME ACHIEVEMENTS 2014: WE ARE ON TRACK SUSTAIN AND GROW THE PAH FRANCHISE BUILD ADDITIONAL SPECIALTY FRANCHISES OPTIMIZE PROFITABILITY Actelion Pharmaceuticals Ltd 08 May 2015
13 OUR STRATEGIC PRIORITIES STAY THE SAME ACHIEVEMENTS 2014: WE ARE ON TRACK SUSTAIN AND GROW THE PAH FRANCHISE BUILD ADDITIONAL SPECIALTY FRANCHISES OPTIMIZE PROFITABILITY Actelion Pharmaceuticals Ltd 08 May 2015
14 OPSUMIT ENGINE OF TRANSFORMATION Opsumit (macitentan) is an orally available endothelin receptor antagonist (ERA) approved for the treatment of PAH in over 30 countries, including the United States in October 2013 and the European Union in December Actelion Pharmaceuticals Ltd 08 May 2015
15 OPEN THE PROSTACYCLIN PATHWAY TO MORE PATIENTS Selexipag (Uptravi) is an investigational drug submitted to health authorities but not approved for use Actelion Pharmaceuticals Ltd 08 May 2015
16 UNIQUELY POSITIONED TO SERVE PAH COVERING CONTINUUM OF CARE WITH OUTCOME-BASED MEDICINES FC II FC III FC IV * Selexipag (Uptravi) is an investigational drug submitted to health authorities but not approved for use Actelion Pharmaceuticals Ltd 08 May 2015
17 OUR CARDIOVASCULAR PIPELINE PROMISING PROJECTS TO DELIVER FUTURE SUCCESS Selexipag PAH Macitentan Eisenmenger syndrome Macitentan CTEPH Macitentan CpcPH Selexipag Raynaud s 2 o to SSc New Chemical Entity Cardiovascular disorders Phase I Phase II Phase III Filing Actelion Pharmaceuticals Ltd 08 May 2015
18 OUR STRATEGIC PRIORITIES STAY THE SAME ACHIEVEMENTS 2014: WE ARE ON TRACK SUSTAIN AND GROW THE PAH FRANCHISE BUILD ADDITIONAL SPECIALTY FRANCHISES OPTIMIZE PROFITABILITY Actelion Pharmaceuticals Ltd 08 May 2015
19 SPECIALTY PRODUCT PORTFOLIO Actelion Pharmaceuticals Ltd 08 May 2015
20 OUR SPECIALTY PIPELINE PROMISING PROJECTS TO DELIVER FUTURE SUCCESS Cadazolid Clostridium difficile assoc. diarrhea Ponesimod Multiple Sclerosis Ponesimod Graft vs. host disease S1P 1 modulator Systemic lupus erythematosus Lucerastat Fabry disease Macitentan Glioblastoma New Chemical Entity Neurological disorders Phase I Phase II Phase III Filing Actelion Pharmaceuticals Ltd 08 May 2015
21 OUR STRATEGIC PRIORITIES STAY THE SAME ACHIEVEMENTS 2014: WE ARE ON TRACK SUSTAIN AND GROW THE PAH FRANCHISE BUILD ADDITIONAL SPECIALTY FRANCHISES OPTIMIZE PROFITABILITY Actelion Pharmaceuticals Ltd 08 May 2015
22 OPTIMIZE PROFITABILITY ACHIEVEMENTS 2014 Strong sales performance Good cost control Markedly increased earnings per share Strong balance sheet assuring financial flexibility Total shareholder return of 55% Actelion Pharmaceuticals Ltd 08 May 2015
23 2015 FOCUS ON EXECUTION MAINTAIN successful Opsumit launch momentum OBTAIN regulatory approval for selexipag (Uptravi) INITIATE and ADVANCE key clinical programs DRIVE shareholder value creation Actelion Pharmaceuticals Ltd 08 May 2015
24 STRONG FINANCIAL PERFORMANCE IN 2014 André C. Muller, CFO Actelion Pharmaceuticals Ltd 08 May 2015
25 FULL YEAR 2014 FINANCIAL OVERVIEW Variance FY 2013 FY 2014 CHF CER Product sales CHF million Core earnings CHF million Operating income CHF million Core EPS CHF 1,784 1,956 10% 12% % 25% % 24% % 33% Actelion Pharmaceuticals Ltd 08 May 2015
26 FULL YEAR 2014 PRODUCT SALES PRODUCTS SALES GROWTH OF 12%, INTRINSIC GROWTH OF 10% CHF million ,784 1,956 1,956 FY '13 Sales FY '14 intrinsic sales growth US rebate reversals FX FY'14 Sales Actelion Pharmaceuticals Ltd 08 May 2015
27 FY 2014: STRONG COMMERCIAL PERFORMANCE TRANSITIONING US + CHF 85 million Europe + CHF 66 million Japan + CHF 16 million RoW +CHF 14 million Opsumit + CHF 175 million Tracleer - CHF 43 million Veletri + CHF 28 million Ventavis + CHF 0.2 million Zavesca + CHF 9 million Others + CHF 12 million Total + CHF 181 million Total + CHF 181 million Actelion Pharmaceuticals Ltd 08 May 2015
28 FY 2014 CORE EARNINGS CORE EARNINGS UP 25% AT CER CHF million ,956 1, Product sales Core COS Core R&D Core SG&A 2014 Core earnings Actelion Pharmaceuticals Ltd 08 May 2015
29 FY 2014 NET INCOME CHF million FY'14 Core earnings Non-core items FY '14 Operating Income Financial result Income tax expense One time deferred tax benefits FY '14 Net Income Actelion Pharmaceuticals Ltd 08 May 2015
30 FY 2014 CASH FLOW CHF million ,036 1, ,205 Unrestricted gross cash 31 Dec 13 Operating cash flow (ex litigation) Litigation payment Released restricted cash Dividend 1st line share purchase Proceeds from ESOP Capex, other items Unrestricted gross cash 31 Dec Actelion Pharmaceuticals Ltd 08 May 2015
31 Q FINANCIAL OVERVIEW Variance Q Q CHF CER Product sales CHF million Core earnings CHF million Operating income CHF million Core EPS CHF % 12% % 18% % 28% % 12% Actelion Pharmaceuticals Ltd 08 May 2015
32 2015 FINANCIAL GUIDANCE AT CONSTANT EXCHANGE RATES Core earnings growth low double-digit percentage range (excl US rebate reversals) Actelion Pharmaceuticals Ltd 08 May 2015
33 CONCLUDING REMARKS BY THE CHAIRMAN OF THE BOARD Actelion Pharmaceuticals Ltd 08 May 2015
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