September 25, EASY ways to register: New York, New York. 3 ways to learn: LIVE meetings are produced. ONLINE products are. PRINT materials are

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1 4325 Alexander Drive Alpharetta, Georgia , USA September 25, 2010 New York, New York 4 EASY ways to register: ONLI NE... FAX +1 (678) CALL +1 (678) ways to learn: PRINT materials are produced by Imedex for your reference needs ONLINE products are produced by Imedex in 6 user-friendly formats MAIL US... Imedex 4325 Alexander Dr. Alpharetta, GA USA LIVE meetings are produced by Imedex in 15 countries Visit to learn more 50% Imedex is committed to environmental excellence. This publication is printed on FSC-certified paper, which is acid-free and elemental chlorine-free, and contains 50% recycled content including 25% post-consumer waste.

2 September 25, 2010 New York, New York Chairs: Cedars-Sinai Medical Center Los Angeles, California David Geffen School of Medicine at UCLA Los Angeles, CA Massachusetts General and Brigham and Women s Hospitals Boston, Massachusetts Stanford University School of Medicine Palo Alto, California 1 st announcement W W W. I M E D E X. C O M

3 Letter from the Chairs Dear Colleague, It is with great pleasure that we invite you to New York for the 2nd annual Management of Women with Chronic Immune Disorders in the Era of Biologics conference to be held September 25, This unique conference will focus on the impact of biological agents and novel drug therapies on the treatment of chronic immune disorders in women - including inflammatory bowel disease, psoriasis, and rheumatoid arthritis. This one day educational event will include presentations by nationally recognized faculty as well as lively interaction via expert-moderated panel discussions. Clinicians across multiple disciplines will be able to benefit from these case-based discussions on challenges and controversies currently surrounding chronic immune disorders. Attendees can expect to leave this conference with not only a greater understanding of how to use biologics safely and with improved patient outcomes but more importantly, better insight into how the presence and management of this group of diseases can impact women from adolescence to adulthood, throughout pregnancy, and entering menopause. These quality of life and social issues are common concerns for female patients and are just as important in determining optimal treatment and management of chronic immune disorders. Please join us in New York for what promises to be a rewarding and highly educational experience. Faculty Eliza Chakravarty, MD Stanford University School of Medicine Stanford, California Cedars-Sinai Medical Center Los Angeles, California Sonia Friedman, MD Brigham and Women s Hospital Harvard Medical School Boston, Massachusetts Harvard University Boston, Massachusetts Daniela Kroshinsky, MD Massachusetts General Hospital Harvard Medical School Boston, Massachusetts Kim L. Isaacs, MD, PhD University of North Carolina Chapel Hill, North Carolina David Geffen School of Medicine at UCLA Los Angeles, CA Stanford University Palo Alto, California Abby Van Voorhees, MD University of Pennsylvania Philadelphia, Pennsylvania Sincerely, Neil S. Silverman, MD

4 September 25, 2010 New York, New York Continuing Medical Education Purdue University School of Pharmacy, an equal access/ equal opportunity institution, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Purdue University School of Pharmacy designates this educational activity for a maximum of 6.0 AMA PRA Category 1 Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity. American Academy of Dermatology The Imedex, LLC s Management of Women with Chronic Immune Disorders in the Era of Biologics (Program #36300) is recognized by the American Academy of Dermatology for 5.5 AAD Recognized Category 1 CME Credits and may be used toward the American Academy of Dermatology s Continuing Medical Education Award. Who Should Attend This activity is intended for gastroenterologists, endocrinologists, rheumatologists, dermatologists, obstetricians, internists, clinical researchers, and other persons in the healthcare community with an interest in the treatment and management of women of all ages with chronic immune diseases (CIDs) such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and psoriasis. Objectives After successful completion of this course, participants should be able to: Discuss the challenges and controversies surrounding therapeutic considerations for biologics in women with chronic immune diseases including, optimal treatment algorithms and classes of agents Comment on the prevalence of chronic immune diseases in women along with accompanying features, symptoms, complications, and special management considerations and how this affects quality of life Describe how IBD affects the pediatric patient, especially pubescent females and how young age affects treatment options for CIDs Assess the long-term risks of cardiovascular events in women with chronic immune disease and how the latest biologics may contribute to these risks Identify how to adequately maintain proper health in women with chronic immune disease using the latest data and recommendations for vaccination, bone monitoring, and cancer screening Analyze the influence of chronic immune disorders such as IBD, RA, spondyloarthopathy, and psoriasis on fertility and/or pregnancy and conversely how pregnancy affects the onset of CIDs Quotes Most organized and most enjoyable conference I ve attended Conference was absolutely great

5 Scientific Agenda Corporate Support The following company has provided an educational grant in support of this conference: Gold 8:00 am Breakfast and registration 8:30 am Introductions and objectives 8:40 am Pre-session audience response survey Several options are available to companies interested in supporting this conference. For more information, please contact Imedex at +1 (770) , or by at Call for Exhibitors Exhibit space is available to companies interested in participating in this conference through exhibition. For more information, please contact Imedex at +1 (678) or by at Conference Organizer 4325 Alexander Drive Alpharetta, Georgia USA Tel.: +1 (770) Fax: +1 (770) :45 am The Young and the Restless: A case-based approach to growth, medication risk, and transition of care Daniela Kroshinsky, MD Speaker invited 9:35 am Q&A with panel discussion: Are children just little adults? Moderator Panelists Daniela Kroshinsky, MD Panelist invited 9:50 am Healthcare maintenance for immune disorders: An update on vaccinations, bone monitoring, and cancer screening Sonia Friedman, MD 10:15 am Post-session audience response survey 10:20 am Break 10:35 am Pre-session audience response survey 10:40 am Quality of life and social connectivity for women: A comparison across immune disorders

6 11:20 am Q&A with panel discussion: Maintaining health and quality of life Moderator Panelist Kim L. Issacs, MD, PhD Sonia Friedman, MD 11:40 am Emerging risks in women with immune disorders: Understanding premature cardiovascular disease and malignancy 12:00 pm Putting risk into perspective: A case-based discussion Moderator 2:20 pm Q&A with Panel discussion: Managing patient s expectations on pregnancy Moderator Panelists Eliza Chakravarty, MD Sonia Friedman, MD 2:50 pm Post-session audience response survey 2:55 pm Summary and concluding remarks 3:00 pm Adjourn Panelists Abby Van Voorhees, MD Kim L. Issacs, MD, PhD 12:25 pm Post-session audience response survey 12:30 pm Lunch 1:15 pm Pre-session audience response survey 1:20 pm Fertility and pregnancy: The impact of chronic immune disorders and treatments Eliza Chakravarty, MD 1:50 pm Perinatal considerations and teratogenicity counseling *Please visit for the most up-to-date agenda and to register.

7 September 25, 2010 New York, New York Hotel Accommodations The Westin New York at Times Square 270 West 43rd Street New York, New York Tel: +1 (212) Fax: +1 (212) For the convenience of attendees, a room block with a limited number of rooms has been reserved at the discounted group rate of $299 single/$319 double occupancy, plus tax, currently at 14.75% plus a $3.50 New York City Occupancy Tax/Javits Center Fee. This limited number of discounted rooms will be available until September 3, This discounted rate is not guaranteed outside the conference dates. Reservations received after September 3, 2010 or after the room block has been filled (whichever comes first) are subject to availability and prevailing hotel rates. To reserve your room please contact the The Westin New York at Times Square reservations department at +1 (212) or visit the hotel s website at www. westinny.com. To receive the group rate, callers must identify themselves as being with the Imedex/The Management of Women with Chronic Immune Disorders in the Era of Biologics group. Reservation requests received after September 3, 2010 may not be guaranteed the group rate. Imedex is a brand and assumed name used by Imedex, LLC (hereby referred to as Imedex). Imedex is solely responsible for this agenda s content. Although Imedex attempts to ensure that the information in our program is accurate and timely, matters and opinions discussed and/or presented with respect to clinical matters are those of the discussion participants only, and not necessarily those of Imedex. Moreover, although Imedex attempts to identify and integrate the most qualified medical professionals in our program, TO THE FULLEST EXTENT PERMITTED BY LAW, IMEDEX EXPRESSLY DISCLAIM ALL WARRANTIES, EITHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT OF THIRD PARTIES RIGHTS, AND FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THE CONTENT PRESENTED. IMEDEX FURTHER MAKES NO REPRESENTATIONS OR WARRANTIES ABOUT THE ACCURACY, RELIABILITY, COMPLETENESS, OR TIMELINESS OF THE CONTENT OR ANY MATERIAL PRESENTED. In addition, the material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual s own physician. Neither Imedex nor any of its subsidiaries or affiliates is affiliated with or formally endorsed by a medical society Imedex, LLC. All rights reserved. Reproduction in whole or part is prohibited without prior written consent from Imedex and contributing faculty. Quotes Excellent conference Continue the program for years to come

8 Registration Fees $99 Physicians Nurses/Residents/Students $49 Group discount (physicians only)* *cannot be combined with any other discounts $75 Registration Procedures To Register: You may register online by September 20, 2010 at by calling Imedex at +1 (678) , or by returning the registration form in this program by mail or fax. If you mail the form, please keep a copy for your records. Registration confirmations will be issued before the meeting. To qualify for special registration fees, registration and full payment must be received by Imedex by the dates specified. Group Discounts: Each one of multiple registrants from the same institute or practice will receive a $24 discount off the published registration fees, provided all registration forms and payments are received together. Only one discount will apply per physician. Discounts are available for physicians only. Payment: To pre-register, registration and payment must be received no later than September 20, Please register onsite after this date. Contact Imedex at +1 (678) or visit our website at to ensure the course is being held as scheduled and to confirm that the meeting is not full. Registration fees must be remitted by credit card or check. Checks should be payable to Imedex. Attendee is not registered until full payment is received. Conference Location and Registration The Westin New York at Times Square 270 West 43rd Street New York, New York Tel: +1 (212) Fax: +1 (212) The Registration and Information Desk will be staffed: Saturday, September 25, :00 am 3:30 pm Registration Fee Inclusions: Registration fees include admittance to all scientific sessions, conference materials, processing of certificates of attendance or continuing medical education, and all event functions as specified in the agenda. Cancellation: For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than September 20, The amount of registration fees remitted, minus a $25 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after September 20, Imedex does not accept responsibility for covering travel, accommodation, or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda is subject to change without notice.

9 September 25, 2010 New York, New York Conference Registration A FIRST NAME LAST NAME MI MD PhD PharmD RN Other SPECIALTY: Dermatology Endocrinology Gastroenterology Nursing OB/GYN Rheumatology Other ADDRESS TELEPHONE FAX INSTITUTE DEPARTMENT ADDRESS CITY STATE / PROVINCE ZIP / POSTAL CODE COUNTRY Check if you require special facilities or assistance and attach a note with specific details and requirements. Registration Fees Physicians $99 Nurse/Student/Resident $49 PAYMENT METHOD Group discount (physicians only)* $75 *cannot be combined with any other discounts American Express MasterCard Visa Check in the amount of: $ Card No. Exp. Date: / Cardholder s Name: Signature: NOTE: After September 17, 2010 only credit card payments will be accepted for pre-registration. To pre-register, registration and payment must be received no later than September 20, Please register onsite after this date. Contact Imedex at +1 (678) or visit our website at to ensure that the meeting is being held as scheduled and to confirm that the meeting is not full. For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than September 20, The amount of registration fees remitted, minus a $25 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after September 20, Imedex does not accept responsibility for covering travel, accommodation, or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda content is subject to change without notice.

10 Audience Participation A Hands-On Experience During the scientific sessions, speakers and the audience can exchange information through a hands-on computerized speaker-audience interaction system. With this state-of-the-art equipment, participants answer multiple choice questions, and within seconds, the answers are calculated and projected on a screen in tabular or graphic form for all to see. This system maximizes the ability for attendees from diverse disciplines to see differing opinions and compare consensus between the speakers and each other. Important Dates Hotel Group Rate Deadline September 3, 2010 Pre-Registration Deadline September 20, 2010 Presentation Date September 25, 2010 Quotes I enjoyed all the speakers. Everyone was very informative as well as interesting