Analysis of Risk Factors for the Development of Incisional and Parastomal Hernias in Patients after Colorectal Surgery

Size: px
Start display at page:

Download "Analysis of Risk Factors for the Development of Incisional and Parastomal Hernias in Patients after Colorectal Surgery"

Transcription

1 Originl Article Journl of the Koren Society of J Koren Soc Coloproctol 2012;28(6): pissn eissn Anlysis of Risk Fctors for the Development of Incisionl nd Prstoml Hernis in Ptients fter Colorectl Surgery In Ho Song, Heon-Kyun H, Sng-Gi Choi, Byeong Geon Jeon, Min Jung Kim, Kyu Joo Prk Deprtment of Surgery, Seoul Ntionl University College of Medicine, Seoul, Kore Purpose: The purpose of this study ws to evlute the overll rte nd risk fctors for the development of n incisionl nd prstoml fter colorectl surgery. Methods: The study cohort consisted of 795 consecutive ptients who underwent open colorectl surgery between 2005 nd 2007 by single surgeon. A retrospective nlysis of prospectively collected dt ws performed. Results: The overll incidence of incisionl s ws 2% (14/690). This study reveled tht the cumultive incidences of incisionl were 1% t 12 months nd 3% fter 36 months. Eighty-six percent of ll incisionl s developed within 3 yers fter colectomy. The overll rte of prstoml s in ptients with stom ws 6.7% (7/105). The incidence of prstoml s ws significntly higher in the colostomy group thn in the ileostomy group (11.9% vs. 0%; P = 0.007). Obesity, bdominl ortic neurysm, Americn Society of Anesthesiol ogists score, serum lbumin level, emergency surgery nd postopertive ileus did not influence the incidence of incisionl or prstoml s. However, the multivrite nlysis reveled tht femle gender nd wound infection were significnt risk fctors for the development of incisionl s femle: P = 0.009, wound infection: P = 0.041). There were no significnt fctors relted to the development of prstoml s. Conclusion: Our results indicte tht most incisionl s develop within 3 yers fter colectomy. Femle gender nd wound infection were risk fctors for the development of n incisionl fter colorectl surgery. In contrst, no significnt fctors were found to be ssocited with the development of prstoml. Keywords: Ventrl ; Surgicl stoms; Ileostomies; Colostomies INTRODUCTION Incisionl s re known to ccount for 2 to 20% of ventrl s fter bdominl surgeries [1-4]. Moreover, ccording to study on s, the incidence of incrcertion is 6 to 15% in ptients with incisionl s [5, 6]. When n incrcerted smll bowel is not immeditely treted, strngultion my occur in 2% of ptients with s [5]. This my led to serious complic- Received: August 14, 2012 Accepted: October 16, 2012 Correspondence to: Kyu Joo Prk, M.D. Deprtment of Surgery, Seoul Ntionl University Hospitl, 101 Dehk-ro, Jongno-gu, Seoul , Kore Tel: , Fx: E-mil: kjprkmd@plz.snu.c.kr 2012 The Koren Society of This is n open-ccess rticle distributed under the terms of the Cretive Commons Attribution Non- Commercil License ( which permits unrestricted noncommercil use, distribution, nd reproduction in ny medium, provided the originl work is properly cited. tions such s intestinl perfortion nd pnperitonitis. Thus, ctive surgicl tretment is criticl for ptients with s. Unlike generl opertions on bdominl orgns, orgn resection nd stom (colostomy nd ileostomy) construction re concurrently performed in most cses during colorectl opertions. Therefore, incisionl s, s well s prstoml s, my lso be ssocited with ventrl s. Although, the incidence of prstoml s increses over time, such s mostly occur within two yers fter stom construction [7, 8]. Prstoml s hve postopertive incidence rte of up to 5 to 30%, higher thn tht of ordinry incisionl s [9]. Although incisionl nd prstoml s re postopertive side effects inducing serious complictions, few studies hve been performed domesticlly on the incidence nd the risk fctors of those s during long-term follow-up periods fter colorectl surgery. Thus, this study imed to identify the incidence nd the risk fctors of bdominl s fter colorectl surgery in Kore. 299

2 Journl of The Koren Society of Anlysis of Risk Fctors for the Development of Incisionl nd Prstoml Hernis in Ptients fter Colorectl Surgery In Ho Song, et l. METHODS This study ws retrospective study with prospective dt collection on ptients who underwent colorectl surgery t Seoul Ntionl University Hospitl from Jnury 2005 to December 2007 in order to nlyze ptients with t lest five-yer follow-up postopertively. To prevent surgeon bis, we included only ptients who received colorectl surgery vi bdominl section from one experienced surgeon. Ptients with pst surgicl history were excluded from the study popultion, nd subjects were only followed until the point of performing nother surgery other thn stom tke-down. The follow-up period lsted until June 2012, nd ll opertions nd the closure of the bdominl wound were conducted with the sme procedure. The incision site ws closed with method of continuous running suture using 1-0 Vicryl (polyglycolic cid), nd the muscle fsci ws closed with the sme suturing method using 1-0 polydioxnone (PDS). The closure ws strengthened with simple interrupted suture using 1-0 Vicryl cid (polyglycolic cid). The study investigted the occurrence of s in ptients who underwent stom construction by clssifying subjects ccording to sex, ge, nd follow-up period, s well s the dependences of the occurrence of bdominl s on the cncer dignosis, the colorectl incision sites, nd the presence nd types of stom. The study exmined the following risk fctors with respect to s: ptient-relted risk fctors were ge, sex, body mss index, bdominl ortic neurysm, preopertive serum hemoglobin level, preopertive serum lbumin level, Americn Society of Anesthesiologists (ASA) score, nd the cuses of surgery. Surgicl risk fctors were the degree of emergency, preopertive bowel obstruction, preopertive bowel perfortion, opertion time, estimted blood loss, the presence of postopertive stom, postopertive infections, postopertive ileus (within 30 dys postopertively), nd dmission dys. The ws exmined by ctegorizing it s n incisionl nd prstoml. The study included cses where s were detected on physicl exmintion nd postopertive rdiologicl exmintion during the follow-up period. The ASA scores of only 770 ptients were recorded for dt collection, nd intropertive bleeding volumes were recorded only in 613 ptients. A life tble ws used in the nlysis of the cumultive survivl rte. A t-test ws used for univrite nlysis nd continuous vribles, nd chi-squre test ws used for ctegoricl vribles. Multivrite nlyses were conducted using cox-regression nlysis on vribles with P 0.1 in the univrite nlysis. All sttisticl nlyses were performed using the SPSS ver (SPSS Inc., Chicgo, IL, USA). RESULTS A totl of 965 ptients received surgery by one surgeon between Jnury 2005 nd December Among those, totl of 795 ptients were included s the study popultion: 690 ptients who did not undergo colostomy tke-down nd 105 ptients with stom tke-down. Subjects were 522 mles nd 273 femles, with men ge of 61 yers old (rnge, 19 to 91; stndrd devition [SD], ±12) nd n verge follow-up period of 39 months (rnge, 0 to 80; SD, ±23). Among ll subjects, incisionl s occurred in 17 ptients: 14 ptients without colostomy tke-down nd 3 ptients who received colostomy tke-down. Moreover, 7 ptients presented with prstoml. The distribution of incisionl nd prstoml s for the vrious types of surgeries is presented in Tble 1. Sixteen ptients with bdominl s underwent surgery. In ddition, eight ptients with conservtive tretment hd been followed up fter ws detected only on computed tomogrphy (CT) scn insted of physicl exmintion. The incidence of incisionl s ws 2% (14/690) in cses without stom construction. In contrst, the incidence of prstoml s ws 6.7% (7/105) in cses with stom construction. Surgery ws performed for prstoml fter n verge period of 3.5 months for 4 out of the 7 ptients who developed prstoml. On the other hnd, surgery ws not conducted on three ptients becuse the ws detected only on CT scn without ny symptoms. Ptients who underwent colostomy tke-down were clssified into ileostomy nd colostomy groups. In the ileostomy group, totl of 46 subjects did not develop prstoml. Among those, 32 ptients received ileostomy closure fter n verge period of 8.5 ± 3.9 months. In ddition, 14 ptients received permnent ileostomy with n verge follow-up period of 19.5 ± 17.7 months. Among the totl of 59 ptients in the colostomy group, 7 (11.9%) developed prstoml. A colostomy closure ws performed on three of those 59 ptients, with n verge follow-up period of 8.6 ± 4.4 months. Fifty-six ptients received permnent colostomy nd were followed for n verge period of over 25.5 ± 21.4 months. All prstoml s occurred in cses involving permnent colostomy. The incidence of prstoml s ws significntly higher in the colostomy group thn in the ileostomy group (P = 0.007) (Tble 2). Of the 14 ptients without stom construction who developed incisionl s, 7.1% (8/14) developed those s during the first postopertive yer, 78.6% (11/14) during the second post- Tble 1. Incidence of ventrl s ccording to dignosis nd site of opertion Opertion site No Incisionl Prstoml Totl Right colon 201 (98.0) 4 (2.0) 0 (0) 205 Left colon 33 (94.3) 2 (5.7) 0 (0) 35 Rectum 502 (96.5) 11 (2.1) 7 (1.4) 520 Others 35 (100) 0 (0) 0 (0) 35 Vlues re presented s number (%). Totl proctocolectomy, totl colectomy, subtotl colectomy nd debulking surgery with colon resection. 300

3 Volume 28, Number 6, 2012 J Koren Soc Coloproctol 2012;28(6): Journl of The Koren Society of opertive yer, nd 85.7% (12/14) during the third postopertive yer. However, incisionl s did not develop fter four yers. The cumultive incidences were 1%, 2%, nd 3% during the first, second, nd third yers, respectively, nd the cumultive incidence Tble 2. Incidence of prstoml s in the stom formtion group Ileostomy Colostomy P-vlue Prstoml Yes 0 (0) 7 (11.9) No 46 (100) 52 (88.1) Tble 3. Chrcteristics of the stom group ccording to the development of n incisionl Chrcteristic No incisionl (n = 676) Incisionl (n = 14) P-vlue Age (yr) 60.9 ± ± Gender Mle 446 (66.0) 4 (28.6) Femle 230 (34.0) 10 (71.4) Obesity 23.0 ± ± AAA 4 (0.6) 0 (0) ASA score (88.2) 11 (78.6) >2 60 (11.8) 3 (21.4) Cncer 649 (96.0) 14 (100) Emergency 8 (1.2) 0 (0) Bowel obstruction 126 (18.6) 2 (14.3) Bowel perfortion 7 (1.0) 1 (7.1) Preopertive nemi 299 (44.2) 7 (50.0) Preopertive hypolbuminemi b 149 (22.0) 3 (21.4) Opertion site Right colon 198 (29.3) 4 (28.6) Left colon 33 (4.9) 2 (14.3) Rectum 419 (62.0) 8 (57.1) Other c 26 (3.8) 0 (0) Opertion time (min) ± ± Estimted blood loss (ml) ± ± Wound infection 43 (6.4) 3 (21.4) Ileus 98 (14.5) 2 (14.3) Hospitl sty (dy) 8.1 ± ± Vlues re presented s men ± stndrd devition or number (%). AAA, bdominl ortic neurysm; ASA score, Americn Society of Anesthesiologists score. Mle, serum hemoglobin 13; nd femle, serum hemoglobin 12. b Serum lbumin 3.0. c Totl proctocolectomy, totl colectomy, subtotl colectomy nd debulking surgery with colon resection. of 3% remined unchnged from the fourth yer. Furthermore, of the 7 ptients with stom construction who developed prstoml s, 28.6% (2/7) developed those s during the first postopertive yer, 57.1% (4/7) during the second postopertive yer, nd 71.4% (5/7) during the third postopertive yer. Only one ptient developed prstoml fter 5 yers. The cumultive incidences were 2%, 7%, nd 9% during the first, second, nd third yer, respectively, nd the incidence rte for prstoml s ws shown to be reltively higher compred to tht for incisionl s. However, the cumultive incidence of prstoml s remined unchnged t 9% fter the fourth yer postopertively. According to univrite nlysis, the risk fctors for n incisionl fter colorectl surgery were relted to the gender of subjects nd showed sttisticlly significnt tendency towrd surgicl wound infection (P = 0.06) (Tble 3). There were no fctors relted to the development of prstoml in the group performed with stom tke-down (Tble 4). The risk fctors for high incidence of incisionl s were identified to be sex (P = 0.009; Tble 4. Chrcteristics of the stom group ccording to the development of prstoml Chrcteristic No prstoml (n = 98) Prstoml (n = 7) P-vlue Age (yr) 60.5 ± ± Gender Mle 67 (68.4) 5 (71.4) Femle 31 (31.6) 2 (28.6) Obesity 23 ± ± AAA 3 (3.1) 0 (0) ASA score (83.7) 6 (85.7) >2 11 (16.3) 1 (14.3) Cncer 89 (90.8) 7 (100) Emergency 11 (11.2) 0 (0) Bowel obstruction 26 (26.5) 0 (0) Bowel perfortion 13 (13.3) 1 (14.3) Preopertive nemi 12.4 ± ± Preopertive hypolbuminemi b 3.7 ± ± Opertion time (min) 153 ± ± Estimted blood loss (ml) 263 ± ± Wound infection 14 (14.3) Ileus 32 (32.7) Hospitl sty (dy) 11 ± ± Vlues re presented s men ± stndrd devition or number (%). AAA, bdominl ortic neurysm; ASA score, Americn Society of Anesthesiologists score. Mle, serum hemoglobin 13; nd femle, serum hemoglobin 12. b Serum lbumin

4 Journl of The Koren Society of Anlysis of Risk Fctors for the Development of Incisionl nd Prstoml Hernis in Ptients fter Colorectl Surgery In Ho Song, et l. Tble 5. Multivrite nlysis of the risk fctors for the development of n incisionl fter colorectl surgery: Cox regression nlysis odds rtio, 4.686; 95% confidence intervl [CI], 1.5 to 15) nd postopertive incisionl infection (P = 0.041; Exp (B), 3.789; 95% CI, 1.1 to 13.6) ccording to the multivrite nlysis conducted on vrible found to hve significnt probbility of 0.1 in the univrite nlysis (Tble 5). DISCUSSION P-vlue Incisionl Odds rtio (95% confidence intervl) Gender (1.5-15) Wound infection ( ) The incidences of incisionl s were reported to be 74.8% nd 88.9% in the first nd the second postopertive yers, respectively, ccording to study by Hoer et l. [10]. Moreover, the incidence of prstoml s incresed over time, nd prstoml s mostly occurred within two yers fter stom construction [7, 8]. Similrly, s developed in 85.7% of the ptients within the third postopertive yer, s reported in previous studies [7, 8, 10]. In ddition, the cumultive incidence remined unchnged from the fourth postopertive yer. When subjects were followed-up over five yers, incisionl nd prstoml s occurred within three yers in most cses, nd lmost no incidence ws observed from the fourth postopertive yer. However, this study detected one cse ech of n incisionl nd prstoml fter five yers. Thus, the possibility of n incisionl or prstoml occurring during long-term follow-up period could not be completely excluded. In this study, the incidence of prstoml s ws exmined by ctegorizing ptients who underwent colostomy tke-down into two subgroups: the ileostomy nd the colostomy subgroups. Prstoml s did not develop in the ileostomy subgroup while 11.9% of the ptients in the colostomy subgroup developed prstoml. According to study by Crne et l. [9] in 2003, the incidences of prstoml s rnged between 1.8 to 28% for n ileostomy nd 4 to 48% for colostomy, exhibiting higher rte in the group with colostomy closure. This study lso found sttisticlly higher significnce for the incidence of prstoml s in the colostomy subgroup. However, temporry enterostomy ws performed in 70% (32/46) of the ptients who received n enterostomy. In contrst, prstoml s were not detected for n enterostomy becuse colostomy closure ws conducted in 5% (3/59) of the ptients. The line lb nd the rectus sheth, which mintin the strength of the bdominl wll, re known to be heled pproximtely 120 dys fter suturing [11]. However, incisionl nd prstoml s my occur in cses of delyed or wekened heling process. The mechnisms nd the risk fctors hve not been clrified. Vrious risk fctors hve been clssified into three subctegories (disese, ptient, nd surgery). Disese-relted risk fctors tht hve been identified re obesity, ulcertive colitis (s opposed to Crohn s disese), constiption, cncer, etc. Ptient-relted risk fctors tht hve been identified re ge, mlnutrition, nd others. In ddition, surgicl risk fctors re emergency opertion (bowel obstruction nd perfortion), postopertive infection, etc. [12, 13]. This study exmined ll fctors tht could be collected from prospective dt. Postopertive wound infection is the third most common form of infection, ccounting for 14 to 16% [14] (up to 3 to 30% [15-18]) of ll infections fter urinry trct infection nd pneumoni. Furthermore, it is lso known to be one of the fundmentl cuses of incisionl s [19, 20]. According to this study, the incidence of postopertive wound infection ws 7.6% (60/7,795), which ws reltively low compred to vlues in previous studies [19, 20]. In ddition, lthough significnt increse ws shown in the incidence of incisionl s in ptients with wound infections (P = 0.041), no reltionship ws found with the incidence of prstoml s. All postopertive wound infections developed t the incision site in the stom construction group. Hence, direct reltionship between wound infection nd stom construction ws unverifible. Some previous studies reported reltionship between sex nd incisionl. The incidence of prstoml ws higher in femles ccording to domestic study performed by Prk et l. [21], nd higher incidence of bdominl s ws found during pregnncy ccording to studies of Seleverstov nd Hllowell [22], nd Weitzmn nd Drimer [23]. However, Lee et l. [24] reported tht no reltionship ws found between sex nd s. Although being femle ws identified to be risk fctor for incresing the incidence of incisionl s, no reltionship ws found between sex nd the incidence of prstoml s. Other fctors, including ptient chrcteristics (ge nd obesity), ptient preopertive risk fctors (blood lbumin level, nemi, ASA score, the presence of tumors, emergency surgery, intestinl obstruction, nd bowel perfortion), surgery-relted risk fctors (opertion time nd intropertive bleeding volume), nd postopertive risk fctors (, postopertive infections, ileus, nd dmission dys) hd no reltionship with the incidence of incisionl s. In prticulr, no risk fctors were found to be ssocited with prstoml s. This study hd severl strengths. First, subjects were comprised of pure study popultions tht received surgery by one surgeon. Second, the study excluded ptients with pst surgicl history nd only included ptients who underwent colorectl surgery, preventing potentil selective bis, unlike other previous studies. Third, 5-yer follow-up period enbled the study to sufficiently investigte the incidences of incisionl nd prstoml s. In conclusion, the risk fctors for the development of incisionl s fter colorectl surgery were gender nd postopertive incisionl infection. However, the study ws unble to detect fctors 302

5 Volume 28, Number 6, 2012 J Koren Soc Coloproctol 2012;28(6): Journl of The Koren Society of relted to the development of prstoml fter colorectl surgery. CONFLICT OF INTEREST No potentil conflict of interest relevnt to this rticle ws reported. REFERENCES 1. Sugermn HJ, Kellum JM Jr, Reines HD, DeMri EJ, Newsome HH, Lowry JW. Greter risk of incisionl with morbidly obese thn steroid-dependent ptients nd low recurrence with prefscil polypropylene mesh. Am J Surg 1996;171: Lewis RT, Wiegnd FM. Nturl history of verticl bdominl prietl closure: Prolene versus Dexon. Cn J Surg 1989;32: Mudge M, Hughes LE. Incisionl : 10 yer prospective study of incidence nd ttitudes. Br J Surg 1985;72: Hodgson NC, Mlthner RA, Ostbye T. The serch for n idel method of bdominl fscil closure: met-nlysis. Ann Surg 2000;231: Red RC, Yoder G. Recent trends in the mngement of incisionl tion. Arch Surg 1989;124: Mnninen MJ, Lvonius M, Perhoniemi VJ. Results of incisionl repir. A retrospective study of 172 unselected hernioplsties. Eur J Surg 1991;157: Mrtin L, Foster G. Prstoml. Ann R Coll Surg Engl 1996;78: Heo SC, Oh HK, Song YS, Seo MS, Choe EK, Ryoo S, et l. Surgicl tretment of prstoml. J Koren Soc Coloproctol 2011;27: Crne PW, Robertson GM, Frizelle FA. Prstoml. Br J Surg 2003;90: Hoer J, Lwong G, Klinge U, Schumpelick V. Fctors influencing the development of incisionl. A retrospective study of 2,983 lprotomy ptients over period of 10 yers. Chirurg 2002; 73: Dougls DM. The heling of poneurotic incisions. Br J Surg 1952; 40: Pilgrim CH, McIntyre R, Biley M. Prospective udit of prstoml : prevlence nd ssocited comorbidities. Dis Colon Rectum 2010;53: Murry BW, Cipher DJ, Phm T, Anthony T. The impct of surgicl site infection on the development of incisionl nd smll bowel obstruction in colorectl surgery. Am J Surg 2011; 202: Smyth ET, Emmerson AM. Surgicl site infection surveillnce. J Hosp Infect 2000;45: Stone HH, Hooper CA, Kolb LD, Geheber CE, Dwkins EJ. Antibiotic prophylxis in gstric, biliry nd colonic surgery. Ann Surg 1976;184: Tng R, Chen HH, Wng YL, Chngchien CR, Chen JS, Hsu KC, et l. Risk fctors for surgicl site infection fter elective resection of the colon nd rectum: single-center prospective study of 2,809 consecutive ptients. Ann Surg 2001;234: Goldring J, McNught W, Scott A, Gillespie G. Prophylctic orl ntimicrobil gents in elective colonic surgery: controlled tril. Lncet 1975;2: Kiser AB, Herrington JL Jr, Jcobs JK, Mulherin JL Jr, Roch AC, Swyers JL. Cefoxitin versus erythromycin, neomycin, nd cefzolin in colorectl opertions. Importnce of the durtion of the surgicl procedure. Ann Surg 1983;198: Chng D, Yng H, Son S, Prk K. Clinicl evlution of incisionl. J Koren Surg Soc 1998;54: Houck JP, Rypins EB, Srfeh IJ, Juler GL, Shimod KJ. Repir of incisionl. Surg Gynecol Obstet 1989;169: Prk PS, Jung YH, Choi KP. A clinicl nlysis of incisionl. J Koren Surg Soc 1993;44: Seleverstov O, Hllowell PT. Ventrl during pregnncy: the single center experience. Am Surg 2011;77:E Weitzmn CC, Drimer MG. Ventrl s compliction of pregnncy. J Int Coll Surg 1949;12: Lee L, Mppin-Ksirer B, Sender Libermn A, Stein B, Chrlebois P, Vssiliou M, et l. High incidence of symptomtic incisionl fter midline extrction in lproscopic colon resection. Surg Endosc 2012;26:

Perforation Following Colorectal Endoscopy: What Happens Beyond the Endoscopy Suite?

Perforation Following Colorectal Endoscopy: What Happens Beyond the Endoscopy Suite? credits vilble for this rticle see pge 88. Originl RESEARCH & CONTRIBUTIONS Perfortion Following Colorectl Endoscopy: Wht Hppens Beyond the Endoscopy Suite? Michel S Tm, MD; Mher A Abbs, MD, FACS, FASCRS

More information

Body mass index, waist-to-hip ratio, and metabolic syndrome as predictors of middle-aged men's health

Body mass index, waist-to-hip ratio, and metabolic syndrome as predictors of middle-aged men's health Originl Article - Sexul Dysfunction/Infertility pissn 2005-6737 eissn 2005-6745 Body mss index, wist-to-hip rtio, nd metbolic syndrome s predictors of middle-ged men's helth Jung Hyun Prk *, In-Chng Cho

More information

The Effects of Small Sized Rice Bowl on Carbohydrate Intake and Dietary Patterns in Women with Type 2 Diabetes

The Effects of Small Sized Rice Bowl on Carbohydrate Intake and Dietary Patterns in Women with Type 2 Diabetes Originl Article doi: 10.4093/kdj.2010.34.3.166 pissn 1976-9180 eissn 2093-2650 The Effects of Smll Sized Rice Bowl on Crbohydrte Intke nd Dietry Ptterns in Women with Type 2 Dibetes Hee-Jung Ahn 1, *,

More information

Original Article. D. Mège, a M. N. Figueiredo, a,b G. Manceau, a L. Maggiori, a Y. Bouhnik, c Y. Panis a. Abstract. 1.

Original Article. D. Mège, a M. N. Figueiredo, a,b G. Manceau, a L. Maggiori, a Y. Bouhnik, c Y. Panis a. Abstract. 1. Journl of Crohn's nd Colitis, 2016, 898 904 doi:10.1093/ecco-jcc/jjw040 Advnce Access publiction Februry 13, 2016 Originl Article Originl Article Three-stge Lproscopic Ilel Pouch-nl Anstomosis Is the Best

More information

Inhaled Corticosteroid Is Associated With an Increased Risk of TB in Patients With COPD

Inhaled Corticosteroid Is Associated With an Increased Risk of TB in Patients With COPD CHEST Originl Reserch Inhled Corticosteroid Is Associted With n Incresed Risk of TB in Ptients With COPD Jung-Hyun Kim, MD ; Ji-Soo Prk, MD ; Kyung-Ho Kim, MD ; Hye-Cheol Jeong, MD ; Eun-Kyung Kim, MD

More information

Emerging Options for Thromboprophylaxis After Orthopedic Surgery: A Review of Clinical Data

Emerging Options for Thromboprophylaxis After Orthopedic Surgery: A Review of Clinical Data Emerging Options for Thromboprophylxis After Orthopedic Surgery: A Review of Clinicl Dt Bob L. Lobo, Phrm.D. In four rndomized, controlled studies of ptients undergoing orthopedic surgery, the ntithrombotic

More information

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn

More information

BENIGN ulceration along the greater curvature of the pars media of the

BENIGN ulceration along the greater curvature of the pars media of the BENIGN ULCERS OF THE GREATER CURVATURE OF THE STOMACH Report of Two Cses CHARLES H. BROWN, M.D. Deprtment of Gstroenterology nd ANTHONY D. INTRIERE, M.D.* BENIGN ulcertion long the greter curvture of the

More information

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess

More information

Effect of Preoperative Intravenous Methocarbamol and Intravenous Acetaminophen on Opioid Use After Primary Total Hip and Knee Replacement

Effect of Preoperative Intravenous Methocarbamol and Intravenous Acetaminophen on Opioid Use After Primary Total Hip and Knee Replacement Feture Article Effect of Preopertive Intrvenous Methocrbmol nd Intrvenous Acetminophen on Opioid Use After Primry Totl Hip nd Knee Replcement THOMAS D. LOOKE, MD, PHD; CAMERON T. KLUTH, MBA bstrct Between

More information

Prophylactic effect of neoadjuvant chemotherapy in gastric cancer patients with postoperative complications

Prophylactic effect of neoadjuvant chemotherapy in gastric cancer patients with postoperative complications Gstric Cncer (2018) 21:703 709 https://doi.org/10.1007/s10120-017-0781-y ORIGINAL ARTICLE Prophylctic effect of neodjuvnt chemotherpy in gstric cncer ptients with postopertive complictions Kojiro Eto 1

More information

Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors

Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors Originl Article Impct of Positive Nodl Metstses in Ptients with Thymic Crcinom nd Thymic Neuroendocrine Tumors Benny Weksler, MD, Anthony Holden, MD, nd Jennifer L. Sullivn, MD Introduction: Thymic crcinoms

More information

T.S. Kurki a, *,U.Häkkinen b, J. Lauharanta c,j.rämö d, M. Leijala c

T.S. Kurki a, *,U.Häkkinen b, J. Lauharanta c,j.rämö d, M. Leijala c Europen Journl of Crdio-thorcic Surgery 20 (2001) 1183 1187 www.elsevier.com/locte/ejcts Evlution of the reltionship between preopertive risk scores, postopertive nd totl length of stys nd hospitl costs

More information

A cross-sectional and follow-up study of leukopenia in tuberculosis patients: prevalence, risk factors and impact of anti-tuberculosis

A cross-sectional and follow-up study of leukopenia in tuberculosis patients: prevalence, risk factors and impact of anti-tuberculosis Originl Article A cross-sectionl nd follow-up study of leukopeni in tuberculosis ptients: prevlence, risk fctors nd impct of nti-tuberculosis tretment Fei-Shen Lin 1 *, Mei-Ying Wu 2 *, Wen-Jun Tu 3, Hong-Qiu

More information

Efficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis

Efficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis Efficcy of Pembrolizumb in Ptients With Advnced Melnom With Stble Brin Metstses t Bseline: A Pooled Retrospective Anlysis Abstrct 1248PD Hmid O, Ribs A, Dud A, Butler MO, Crlino MS, Hwu WJ, Long GV, Ancell

More information

Supplementary Online Content

Supplementary Online Content Supplementry Online Content Zulmn DM, Pl Chee C, Ezeji-Okoye SC, et l. Effect of n intensive outptient progrm to ugment primry cre for high-need Veterns Affirs ptients: rndomized clinicl tril. JAMA Intern

More information

Lung cancer is the leading cause of cancer death worldwide, EGFR Mutation and Brain Metastasis in Pulmonary Adenocarcinomas

Lung cancer is the leading cause of cancer death worldwide, EGFR Mutation and Brain Metastasis in Pulmonary Adenocarcinomas Originl Article EGFR Muttion nd Brin Metstsis in Pulmonry Adenocrcinoms Dong-Yeop Shin, MD,* Im Il N, MD,* Cheol Hyeon Kim, MD, PhD, Sunhoo Prk, MD, PhD, HeeJong Bek, MD, PhD, nd Sung Hyun Yng, MD, PhD*

More information

Opioid Use and Survival at the End of Life: A Survey of a Hospice Population

Opioid Use and Survival at the End of Life: A Survey of a Hospice Population 532 Journl of Pin nd Symptom Mngement Vol. 32 No. 6 December 2006 NHPCO Originl Article Opioid Use nd Survivl t the End of Life: A Survey of Hospice Popultion Russell K. Portenoy, MD, Un Sibircev, BA,

More information

EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1

EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 Swine Dy 2001 Contents EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 C. W. Hstd, S. S. Dritz 2, J. L. Nelssen, M. D. Tokch, nd R. D. Goodbnd Summry Two trils were

More information

Prognostic significance of pretreatment serum levels of albumin, LDH and total bilirubin in patients with nonmetastatic

Prognostic significance of pretreatment serum levels of albumin, LDH and total bilirubin in patients with nonmetastatic Crcinogenesis, 2015, Vol. 36, No. 2, 243 248 doi:10.1093/crcin/bgu247 Advnce Access publiction December 18, 2014 Originl Mnuscript originl mnuscript Prognostic significnce of pretretment serum levels of

More information

Effect on Glycemic, Blood Pressure, and Lipid Control according to Education Types

Effect on Glycemic, Blood Pressure, and Lipid Control according to Education Types Originl Article http://dx.doi.org/10.4093/dmj.2011.35.6.580 pissn 2233-6079 eissn 2233-6087 D I A B E T E S & M E T A B O L I S M J O U R N A L Effect on Glycemic, Blood Pressure, nd Lipid Control ccording

More information

CME/SAM. Study on Hyperuricemia in HBV-Associated Glomerulonephritis

CME/SAM. Study on Hyperuricemia in HBV-Associated Glomerulonephritis AJCP / Originl Article Study on Hyperuricemi in HBV-Associted Glomerulonephritis Yongze Zhung, MD, PhD, 1 Yingho Yu, MD, PhD, 2 Yingfng Hung, MD, 3 nd Xiorong Zhong, MD 1 From the 1 Deprtment of Nephrology,

More information

Original Article INTRODUCTION. Korean Diabetes J 2010;34: doi: /kdj pissn eissn

Original Article INTRODUCTION. Korean Diabetes J 2010;34: doi: /kdj pissn eissn Originl Article doi: 1.493/kdj.21.34.6.34 pissn 1976-918 eissn 293-265 The Smll Rice Bowl-Bsed Mel Pln ws Effective t Reducing Dietry Energy Intke, Body Weight, nd Blood Glucose Levels in Koren Women with

More information

Community. Profile Powell County. Public Health and Safety Division

Community. Profile Powell County. Public Health and Safety Division Community Helth Profile 2015 Powell County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk

More information

Relationship between bronchial anthracofibrosis and endobronchial tuberculosis

Relationship between bronchial anthracofibrosis and endobronchial tuberculosis ORIGINAL ARTICLE Koren J Intern Med 2013;28:330-338 Reltionship between bronchil nthrcofibrosis nd endobronchil tuberculosis Hyun Ji Kim, Sng Dong Kim, Dong Woo Shin, Soo Hyun Be, Ah Lim Kim, Ji N Kim,

More information

Community. Profile Lewis & Clark County. Public Health and Safety Division

Community. Profile Lewis & Clark County. Public Health and Safety Division Community Helth Profile 2015 Lewis & Clrk County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl

More information

Department of Surgery, Central Hospital of Central Finland, Jyväskylä, Finland 2

Department of Surgery, Central Hospital of Central Finland, Jyväskylä, Finland 2 557016SJS0010.1177/1457496914557016Fst-trck colorectl surgerya. Ehrlich, et l. reserch-rticle2014 ORIGINAL ARTICLE Comprison of lproscopic nd colonic resection within fst-trck nd trditionl periopertive

More information

ORIGINAL RESEARCH & CONTRIBUTIONS

ORIGINAL RESEARCH & CONTRIBUTIONS credits vilble for this rticle see pge 96. ORIGINAL RESEARCH & CONTRIBUTIONS Sfely Increse the Minimlly Invsive Hysterectomy Rte: A Novel Three-Tiered Preopertive Ctegoriztion System Cn Predict the Difficulty

More information

LATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1

LATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1 LATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1 W. G. J. HAMPSON nd P. HILL, BRISTOL, ENGLAND The uthors wished to determine the lte results of the Huser opertion,

More information

Reports of cases of AIDS, HIV infection, and HIV/AIDS 1

Reports of cases of AIDS, HIV infection, and HIV/AIDS 1 Reports of cses of AIDS, HIV infection, nd HIV/AIDS 1 The HIV/AIDS Surveillnce Report is published nnully by the Division of HIV/AIDS Prevention Surveillnce nd Epidemiology, Ntionl Center for HIV, STD,

More information

Original Article. Heon-Mook Park a ; Yang-Ku Lee b ; Jin-Young Choi c ; Seung-Hak Baek d

Original Article. Heon-Mook Park a ; Yang-Ku Lee b ; Jin-Young Choi c ; Seung-Hak Baek d Originl Article Mxillry incisor inclintion of skeletl Clss III ptients treted with extrction of the upper first premolrs nd two-jw surgery Conventionl orthognthic surgery vs surgery-first pproch Heon-Mook

More information

Metabolic Syndrome and Health-related Quality of Life in Obese Individuals Seeking Weight Reduction

Metabolic Syndrome and Health-related Quality of Life in Obese Individuals Seeking Weight Reduction Metbolic Syndrome nd Helth-relted Qulity of Life in Obese Individuls Seeking Weight Reduction Adm Gilden Tsi 1, Thoms A. Wdden 1, Dvid B. Srwer 1, Robert I. Berkowitz 1, Leslie G. Womble 1, Louise A. Hesson

More information

Impact of Pharmacist Intervention on Diabetes Patients in an Ambulatory Setting

Impact of Pharmacist Intervention on Diabetes Patients in an Ambulatory Setting Impct of Phrmcist Intervention on Dibetes Ptients in n Ambultory Setting Julie Stding, PhrmD, CDE, Jmie Herrmnn, PhrmD, Ryn Wlters, MS, Chris Destche, PhrmD, nd Aln Chock, PhrmD Dibetes is the seventh-leding

More information

Multiple sclerosis (MS) affects approximately. Triaging Patients with Multiple Sclerosis in the Emergency Department. Room for Improvement

Multiple sclerosis (MS) affects approximately. Triaging Patients with Multiple Sclerosis in the Emergency Department. Room for Improvement Systemtic Review of Tools for Anxiety in MS MS CARE DELIVERY: CHALLENGES AND INVATIONS Triging Ptients with Multiple Sclerosis in the Emergency Deprtment Room for Improvement Heshm Abboud, MD, PhD; Krin

More information

Community. Profile Big Horn County. Public Health and Safety Division

Community. Profile Big Horn County. Public Health and Safety Division Community Helth Profile 2015 Big Horn County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl

More information

Community. Profile Yellowstone County. Public Health and Safety Division

Community. Profile Yellowstone County. Public Health and Safety Division Community Helth Profile 2015 Yellowstone County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl

More information

Community. Profile Anaconda- Deer Lodge County. Public Health and Safety Division

Community. Profile Anaconda- Deer Lodge County. Public Health and Safety Division Community Helth Profile 2015 Ancond- Deer Lodge County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12

More information

Community. Profile Missoula County. Public Health and Safety Division

Community. Profile Missoula County. Public Health and Safety Division Community Helth Profile 2015 Missoul County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk

More information

Laparoscopic gastric bypass vs sleeve gastrectomy in obese Korean patients

Laparoscopic gastric bypass vs sleeve gastrectomy in obese Korean patients Submit Mnuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.spx DOI: 10.3748/wjg.v21.i44.12612 World J Gstroenterol 15 November 28; 21(44): 12612-12619 ISSN 1007-9327 (print)

More information

Perioperative Hyperglycemia and Postoperative Infection after Lower Limb Arthroplasty

Perioperative Hyperglycemia and Postoperative Infection after Lower Limb Arthroplasty Journl of Dibetes Science nd Technology Volume 5, Issue 2, Mrch 2011 Dibetes Technology Society ORIGINAL ARTICLES Periopertive Hyperglycemi nd Postopertive Infection fter Lower Limb Arthroplsty Boris,

More information

Invasive Pneumococcal Disease Quarterly Report. July September 2017

Invasive Pneumococcal Disease Quarterly Report. July September 2017 Invsive Pneumococcl Disese Qurterly Report July September 2017 Prepred s prt of Ministry of Helth contrct for scientific services by Rebekh Roos Helen Heffernn October 2017 Acknowledgements This report

More information

Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population

Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population Originl Article Clinicl sttistics nlysis on the chrcteristics of pneumoconiosis of Chinese miner popultion Mei-Fng Wng 1 *, Run-Ze Li 2 *, Ying Li 2, Xue-Qin Cheng 1, Jun Yng 1, Wen Chen 3, Xing-Xing Fn

More information

Original Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract:

Original Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract: Fridpur Med. Coll. J. 214;9(2):61-67 Originl Article Nebuliztion by Isotonic Mgnesium Sulphte Solution with Provide Erly nd Better Response s Compred to Conventionl Approch ( Plus Norml Sline) in Acute

More information

Esophageal carcinoma is the eighth most common cancer

Esophageal carcinoma is the eighth most common cancer ORIGINAL ARTICLE Tumor-Strom Rtio Is n Independent Predictor for Survivl in Esophgel Squmous Cell Crcinom Ki Wng, MD,* Wei M, MD,* Jinbo Wng, MD,* Ling Yu, MD, Xiomei Zhng, MD, Zhenbo Wng, MD, Bingxu Tn,

More information

Classic Papillary Thyroid Carcinoma with Tall Cell Features and Tall Cell Variant Have Similar Clinicopathologic Features

Classic Papillary Thyroid Carcinoma with Tall Cell Features and Tall Cell Variant Have Similar Clinicopathologic Features The Koren Journl of Pthology 2014; 48: 201-208 ORIGINAL ARTICLE Clssic Ppillry Thyroid Crcinom with Tll Cell Fetures nd Tll Cell Vrint Hve Similr Clinicopthologic Fetures Woo Jin Oh 1 Young Sub Lee 1 Uiju

More information

Patient Survival After Surgical Treatment of Rectal Cancer

Patient Survival After Surgical Treatment of Rectal Cancer Originl Article Ptient Survivl After Surgicl Tretment of Rectl Cncer Impct of Surgeon nd Hospitl Chrcteristics Dvid A. Etzioni, MD, MSHS 1,2 ; Toni M. Young-Fdok, MD, MS 1 ; Robert R. Cim, MD, MA 2,3 ;

More information

A review of the patterns of docetaxel use for hormone-resistant prostate cancer at the Princess Margaret Hospital

A review of the patterns of docetaxel use for hormone-resistant prostate cancer at the Princess Margaret Hospital MEDICAL ONCOLOGY A review of the ptterns of docetxel use for hormone-resistnt prostte cncer t the Princess Mrgret Hospitl S.N. Chin MD,* L. Wng MSc, M. Moore MD,* nd S.S. Sridhr MD MSc* ABSTRACT Bckground

More information

Assessment of Depression in Multiple Sclerosis. Validity of Including Somatic Items on the Beck Depression Inventory II

Assessment of Depression in Multiple Sclerosis. Validity of Including Somatic Items on the Beck Depression Inventory II Assessment of Depression in Multiple Sclerosis Vlidity of Including Somtic Items on the Beck Depression Inventory II Peggy Crwford, PhD; Noh J. Webster, MA Signs nd symptoms of multiple sclerosis (MS)

More information

The Relationship between Metformin and Cancer in Patients with Type 2 Diabetes

The Relationship between Metformin and Cancer in Patients with Type 2 Diabetes Originl Article Epidemiology http://dx.doi.org/10.4093/dmj.2013.37.2.125 pissn 2233-6079 eissn 2233-6087 D I A B E T E S & M E T A B O L I S M J O U R N A L The Reltionship between Metformin nd Cncer in

More information

Retrospective Study of Postoperative Pulmonary Complications in Patients with Cervical Spine Pathology

Retrospective Study of Postoperative Pulmonary Complications in Patients with Cervical Spine Pathology 98 Pulmonry Originl Article Compliction fter Cervicl Spine Surgery THIEME Retrospective Study of Postopertive Pulmonry Complictions in Ptients with Cervicl Spine Pthology Sury Kumr Dube 1 Mihir Prksh Pndi

More information

Risk of Colorectal Cancer by Subsite in a Swedish Prostate Cancer Cohort

Risk of Colorectal Cancer by Subsite in a Swedish Prostate Cancer Cohort Specil Report Risk of Colorectl Cncer by Subsite in Swedish Prostte Cncer Cohort Yunxi Lu, MD, PhD, Rickrd Ljung, MD, PhD, Ann Mrtling, MD, PhD, nd Mts Lindbld, MD, PhD Bckground: The reltionship between

More information

C reactive protein: an aid to assessment and

C reactive protein: an aid to assessment and C rective protein: n id to ssessment nd monitoring of cute pncretitis J Clin Pthol 1984;37:27-211 AD MAYR,* MJ McMAHON,* MARGART BOWN,t H COOPRt From the *University Deprtment ofsurgery, Generl Infrmry,

More information

Effects of 6-Month Sitagliptin Treatment on Insulin and Glucagon Responses in Korean Patients with Type 2 Diabetes Mellitus

Effects of 6-Month Sitagliptin Treatment on Insulin and Glucagon Responses in Korean Patients with Type 2 Diabetes Mellitus Originl Article Others Dibetes Metb J 215;39:335-341 http://dx.doi.org/1.493/dmj.215.39.4.335 pissn 2233-679 eissn 2233-687 DIABETES & METABOLISM JOURNAL Effects of 6-Month Sitgliptin Tretment on Insulin

More information

Increased Relative Mortality in Women With Severe Oxygen-Dependent COPD

Increased Relative Mortality in Women With Severe Oxygen-Dependent COPD CHEST Originl Reserch Incresed Reltive Mortlity in Women With Severe Oxygen-Dependent COPD Mgnus Ekström, MD ; Krl A. Frnklin, MD, PhD ; nd Kerstin E. Ström, MD, PhD COPD Bckground: Although the incidence

More information

Community. Profile Carter County. Public Health and Safety Division

Community. Profile Carter County. Public Health and Safety Division Community Helth Profile 2015 Crter County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk

More information

Biliary tract cancer treatment: 5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan

Biliary tract cancer treatment: 5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan J Heptoiliry Pncret Surg (2009) 16:1 7 DOI 10.1007/s00534-008-0015-0 TOPICS Biliry trct cncer sttistics registry in Jpn Biliry trct cncer tretment: 5,584 results from the Biliry Trct Cncer Sttistics Registry

More information

THE natural course of sciatica 22,17,23 is favourable in most

THE natural course of sciatica 22,17,23 is favourable in most Predicting the outcome of scitic t short-term follow-up Ptrick C A J Vroomen, M C T F M de Krom nd J A Knottnerus Originl ppers SUMMARY Bckground: The prognostic vlue of the clinicl findings elicited in

More information

Standardised Frailty Indicator as Predictor for Postoperative Delirium after Vascular Surgery: A Prospective Cohort Study

Standardised Frailty Indicator as Predictor for Postoperative Delirium after Vascular Surgery: A Prospective Cohort Study Eur J Vsc Endovsc Surg (2011) 42, 824e830 Stndrdised Frilty Indictor s Predictor for Postopertive Delirium fter Vsculr Surgery: A Prospective Cohort Study R.A. Pol, B.L. vn Leeuwen, L. Visser, G.J. Izks

More information

A Multicenter, Retrospective Study to Evaluate the Effect of Preoperative Stoma Site Marking on Stomal and Peristomal Complications

A Multicenter, Retrospective Study to Evaluate the Effect of Preoperative Stoma Site Marking on Stomal and Peristomal Complications A Multicenter, Retrospective Study to Evlute the Effect of Preopertive Stom Site Mrking on Stoml nd Peristoml Complictions Zehr Gocmen Bykr, PhD, RN; Sevil Guler Demir, PhD, RN; Ayise Krdg, PhD, RN; Deniz

More information

URINARY incontinence is an important and common

URINARY incontinence is an important and common Urinry incontinence in older people in the community: neglected problem? Helen Stoddrt, Jenny Donovn, Elise Whitley, Deborh Shrp nd In Hrvey SUMMARY Bckground: The prevlence nd impct of urinry incontinence

More information

Addendum to the Evidence Review Group Report on Aripiprazole for the treatment of schizophrenia in adolescents (aged years)

Addendum to the Evidence Review Group Report on Aripiprazole for the treatment of schizophrenia in adolescents (aged years) Addendum to the Evidence Review Group Report on Aripiprzole for the tretment of schizophreni in dolescents (ged 15-17 yers) Produced by Authors Correspondence to Southmpton Helth Technology Assessments

More information

Metformin and breast cancer stage at diagnosis: a population-based study

Metformin and breast cancer stage at diagnosis: a population-based study ORIGINAL ARTICLE METFORMIN AND BREAST CANCER STAGE AT DIAGNOSIS, Leg et l. Metformin nd brest cncer stge t dignosis: popultion-bsed study I.C. Leg md msc,* K. Fung msc,* P.C. Austin phd, nd L.L. Lipscombe

More information

Analysis of alternatives for insulinizing patients to achieve glycemic control and avoid accompanying risks of hypoglycemia

Analysis of alternatives for insulinizing patients to achieve glycemic control and avoid accompanying risks of hypoglycemia 284 Anlysis of lterntives for izing ptients to chieve glycemic control nd void ccompnying risks of hypoglycemi JIALIN GAO 1,2*, QIANYIN XIONG 1,2*, JUN MIAO 1*, YAO ZHANG 2,3, LIBING XIA 1, MEIQIN LU 1,

More information

Characteristics of hip involvement in patients with ankylosing spondylitis in Korea

Characteristics of hip involvement in patients with ankylosing spondylitis in Korea ORIGINAL ARTICLE Koren J Intern Med 2017;32:158-164 Chrcteristics of hip involvement in ptients with nkylosing spondylitis in Kore Hyemin Jeong, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jejoon Lee, Eun-Mi

More information

Age related differences in prognosis and prognostic factors among patients with epithelial ovarian cancer

Age related differences in prognosis and prognostic factors among patients with epithelial ovarian cancer MOLECULAR AND CLINICAL ONCOLOGY 9: 329-334, 2018 Age relted differences in prognosis nd prognostic fctors mong ptients with epithelil ovrin cncer KENJI YOSHIKAWA, TAKESHI FUKUDA, RYO UEMURA, HIROAKI MATSUBARA,

More information

Using Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids

Using Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids Using Pcloutrzol to Suppress Inflorescence Height of Potted Phlenopsis Orchids A REPORT SUBMITTED TO FINE AMERICAS Linsey Newton nd Erik Runkle Deprtment of Horticulture Spring 28 Using Pcloutrzol to Suppress

More information

Influence of lateral cephalometric radiography in orthodontic diagnosis and treatment planning

Influence of lateral cephalometric radiography in orthodontic diagnosis and treatment planning Originl Article Influence of lterl cephlometric rdiogrphy in orthodontic dignosis nd tretment plnning An Reis Durão ; Ali Alqerbn b ; Afonso Pinhão Ferreir c ; Reinhilde Jcobs d ABSTRACT Objective: To

More information

Health-Related Quality of Life and Symptoms of Depression in Extremely Obese Persons Seeking Bariatric Surgery

Health-Related Quality of Life and Symptoms of Depression in Extremely Obese Persons Seeking Bariatric Surgery Oesity Surgery, 15, 3-39 Helth-Relted Qulity of Life nd Symptoms of Depression in Extremely Oese Persons Seeking Britric Surgery Anthony N. Frictore, PhD; Thoms A. Wdden, PhD; Dvid B. Srwer, PhD; Myles

More information

Breast-Conserving Surgery Under Local Anesthesia in Elderly Patients with Severe Cardiorespiratory Comorbidities: A Hospital-Based Case-Control Study

Breast-Conserving Surgery Under Local Anesthesia in Elderly Patients with Severe Cardiorespiratory Comorbidities: A Hospital-Based Case-Control Study Originl Article Brest Cre 2017;12:29 33 DOI: 10.1159/000455003 Published online: Februry 8, 2017 Brest-Conserving Surgery Under Locl in Elderly Ptients with Severe Crdiorespirtory Comorbidities: A Hospitl-Bsed

More information

Mortality of patients with multiple sclerosis: a cohort study in UK primary care

Mortality of patients with multiple sclerosis: a cohort study in UK primary care Mortlity of ptients with multiple sclerosis: cohort study in UK primry cre The Hrvrd community hs mde this rticle openly vilble. Plese shre how this ccess benefits you. Your story mtters Cittion Jick,

More information

Urinary Tract Infection in Men

Urinary Tract Infection in Men C H A P T E R 1 9 Urinry Trct Infection in Men Toms L. Griebling, MD Associte Professor & Vice Chir of Urology University of Knss Knss City, Knss Contents INTRODUCTION........................................623

More information

SYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT

SYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT Finl Arevited Clinicl Study Report Nme of Sponsor/Compny: Bristol-Myers Squi Ipilimum Individul Study Tle Referring to the Dossier (For Ntionl Authority Use Only) Nme of Finished Product: Yervoy Nme of

More information

Effectiveness of Belt Positioning Booster Seats: An Updated Assessment

Effectiveness of Belt Positioning Booster Seats: An Updated Assessment ARTICLES Effectiveness of Belt Positioning Booster Sets: An Updted Assessment AUTHORS: Kristy B. Arbogst, PhD, Jessic S. Jermkin, DSc, Michel J. Klln, MS, b nd Dennis R. Durbin, MD, MSCE,b Center for Injury

More information

Staffing Model for Dental Wellness and Readiness

Staffing Model for Dental Wellness and Readiness MILITARY MEDICINE, 169, 8:604, 2004 Stffing Model for Dentl Wellness nd Rediness Gurntor: LTC Jeffrey Chffin, DC USA Contributors: COL Lrry G. Rothfuss, DC USA* ; LCDR Scott A. Johnson, NC USN* ; MAJ Stephen

More information

Cord Injuries. on admission, and intermittent catheterization. (IC) was carried out until spontaneous voiding occurred.

Cord Injuries. on admission, and intermittent catheterization. (IC) was carried out until spontaneous voiding occurred. JOURNAL OF CLINICAL MICROBIOLOGY, Nov. 1982, P. 856-860 0095-1137/82/110856-05$02.00/0 Copyright 1982, Americn Society for Microbiology Vol. 16, No. 5 Pseudomons eruginos Coloniztion in Ptients with Spinl

More information

XII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV

XII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV XII. HIV/AIDS Knowledge bout HIV Trnsmission nd Misconceptions bout HIV One of the most importnt prerequisites for reducing the rte of HIV infection is ccurte knowledge of how HIV is trnsmitted nd strtegies

More information

Comparison of hand assisted laparoscopic surgery and conventional laparotomy for rectal cancer: Interim results from a single center

Comparison of hand assisted laparoscopic surgery and conventional laparotomy for rectal cancer: Interim results from a single center MOLECULAR AND CLINICAL ONCOLOGY 3: 533-538 Comprison of hnd ssisted lproscopic surgery nd conventionl lprotomy for rectl cncer: Interim results from single center TAKAYUKI TAJIMA 1, MASAYA MUKAI 2, WATARU

More information

MOLECULAR AND CLINICAL ONCOLOGY 5: , 2016

MOLECULAR AND CLINICAL ONCOLOGY 5: , 2016 MOLECULAR AND CLINICAL ONCOLOGY 5: 429-436, 2016 Improvement of survivl with postmstectomy rdiotherpy in ptients with 1-3 positive xillry lymph nodes: A systemtic review nd met-nlysis of the current literture

More information

HIV Surveillance in Women. National Center for HIV/AIDS, Viral Hepatitis, STD & TB Prevention Division of HIV/AIDS Prevention

HIV Surveillance in Women. National Center for HIV/AIDS, Viral Hepatitis, STD & TB Prevention Division of HIV/AIDS Prevention HIV Surveillnce in Women Ntionl Center for HIV/AIDS, Virl Heptitis, STD & TB Prevention Division of HIV/AIDS Prevention Dignoses of HIV Infection mong Adult nd Adolescent Femles, by Rce/Ethnicity, 2006

More information

Hospital readmission after a pancreaticoduodenectomy: an emerging quality metric?

Hospital readmission after a pancreaticoduodenectomy: an emerging quality metric? DOI:10.1111/j.1477-2574.2012.00563.x HPB ORIGINAL ARTICLE Hospitl redmission fter pncreticoduodenectomy: n emerging qulity metric? Zchry J. Kstenberg, John M. Morton, Brendn C. Visser, Jeffrey A. Norton

More information

thyroidectomy for primary thyrotoxicosis

thyroidectomy for primary thyrotoxicosis J clin Pth, 1975, 28, 94-98 The predictive vlue of histometry of thyroid tissue in nticipting hypothyroidism fter subtotl thyroidectomy for primry thyrotoxicosis R J YOUNG, J SWNSON BECK', ND W MICHIE

More information

Rheumatoid-susceptible alleles of HLA-DRB 1 are genetically recessive to non-susceptible alleles in the progression of bone destruction in the wrists

Rheumatoid-susceptible alleles of HLA-DRB 1 are genetically recessive to non-susceptible alleles in the progression of bone destruction in the wrists Annls of the Rheumtic Diseses 1994; 53: 587-592 587 Deprtment of Orthopedic Surgery, Knsi Medicl University, Otokoym Hospitl, Kyoto, Jpn Y Tod Y Mori Deprtment of Orthopedic Surgery, Knsi Medicl University,

More information

American Joint Committee on Cancer Staging and Clinicopathological High-Risk Predictors of Ocular Surface Squamous Neoplasia

American Joint Committee on Cancer Staging and Clinicopathological High-Risk Predictors of Ocular Surface Squamous Neoplasia Americn Joint Committee on Cncer Stging nd Clinicopthologicl High-Risk Predictors of Oculr Surfce Squmous Neoplsi A Study From Tertiry Eye Center in Indi Sheetl Chuhn, MSc; Seem Sen, MD; Anjn Shrm, PhD;

More information

Relationship Between Hospital Performance on a Patient Satisfaction Survey and Surgical Quality

Relationship Between Hospital Performance on a Patient Satisfaction Survey and Surgical Quality Reserch Originl Investigtion Reltionship Between Hospitl Performnce on Ptient Stisfction Survey nd Surgicl Qulity Greg D. Scks, MD, MPH; Elise H. Lwson, MD, MSHS; Aron J. Dwes, MD; Mrci M. Russell, MD;

More information

Endourology. Youn Chul You, Tae Hyo Kim, Gyung Tak Sung. INTRODUCTION

Endourology. Youn Chul You, Tae Hyo Kim, Gyung Tak Sung.   INTRODUCTION www.kjurology.org http://dx.doi.org/10.4111/kju.01.53.1.9 Endourology Effect of Bldder Neck Preservtion nd Posterior Urethrl Reconstruction during Robot-Assisted Lproscopic Rdicl Prosttectomy for Urinry

More information

Natural History and Treatment of Wilms's Tumour : An Analysis of 335 Cases Occurring in England and Wales

Natural History and Treatment of Wilms's Tumour : An Analysis of 335 Cases Occurring in England and Wales 24 October MEDCL JOURNL 15 Ppers nd Originls Nturl History nd Tretment Wilms's Tumour : n nlysis 335 Cses Occurring in Englnd nd Wles 12- E. M. LEDLE,* M.B., B.S., D.M.R.; L. S. MYNORS,* M.B., B.S.; G.

More information

Prevalence of Diabetes Mellitus and Prediabetes in Dalseong-gun, Daegu City, Korea

Prevalence of Diabetes Mellitus and Prediabetes in Dalseong-gun, Daegu City, Korea Originl Article doi: 10.4093/dmj.2011.35.3.255 pissn 2233-6079 eissn 2233-6087 D I A B E T E S & M E T A B O L I S M J O U R N A L Prevlence of Dibetes Mellitus nd Predibetes in Dlseong-gun, Degu City,

More information

EXPOSURE TO EXCESSIVE SOUNDS AND HEARING STATUS IN ACADEMIC CLASSICAL MUSIC STUDENTS

EXPOSURE TO EXCESSIVE SOUNDS AND HEARING STATUS IN ACADEMIC CLASSICAL MUSIC STUDENTS Interntionl Journl of Occuptionl Medicine nd Environmentl Helth 2017;30(1):55 75 https://doi.org/10.13075/ijomeh.1896.00709 EXPOSURE TO EXCESSIVE SOUNDS AND HEARING STATUS IN ACADEMIC CLASSICAL MUSIC STUDENTS

More information

Original Article Clinical Care/Education INTRODUCTION DIABETES & METABOLISM JOURNAL

Original Article Clinical Care/Education INTRODUCTION DIABETES & METABOLISM JOURNAL Originl Article Clinicl Cre/Eduction https://doi.org/10.4093/dmj.2018.42.1.28 pissn 2233-6079 eissn 2233-6087 DIABETES & METABOLISM JOURNAL Improvement of Glycosylted Hemoglobin in Ptients with Type 2

More information

Lipase and Pancreatic Amylase Activities in Tissues and in Patients with Hyperamylasemia

Lipase and Pancreatic Amylase Activities in Tissues and in Patients with Hyperamylasemia CLINICAL CHEMISTRY Originl Article Lipse nd Pncretic Amylse Activities in Tissues nd in Ptients with Hypermylsemi FRED APPLE, PH.D, PETER BENSON, M.D., LYNNE PREESE, MT, M.B.A., STEVEN EASTEP, M.D., LAURA

More information

Geographical influence on digit ratio (2D:4D): a case study of Andoni and Ikwerre ethnic groups in Niger delta, Nigeria.

Geographical influence on digit ratio (2D:4D): a case study of Andoni and Ikwerre ethnic groups in Niger delta, Nigeria. Journl of Applied Biosciences 27: 1736-1741 ISSN 1997 5902 Geogrphicl influence on digit rtio (2D:4D): cse study of Andoni nd Ikwerre ethnic groups in Niger delt, Nigeri. Gwunirem, Isrel U 1 nd Ihemelndu,

More information

Utilization of dental services in Southern China. Lo, ECM; Lin, HC; Wang, ZJ; Wong, MCM; Schwarz, E

Utilization of dental services in Southern China. Lo, ECM; Lin, HC; Wang, ZJ; Wong, MCM; Schwarz, E Title Utiliztion of dentl services in Southern Chin Author(s) Lo, ECM; Lin, HC; Wng, ZJ; Wong, MCM; Schwrz, E Cittion Journl Of Dentl Reserch, 2001, v. 80 n. 5, p. 1471-1474 Issued Dte 2001 URL http://hdl.hndle.net/10722/53200

More information

First Experience in Quality of Life Analysis After Bariatric Surgery

First Experience in Quality of Life Analysis After Bariatric Surgery DOI: 10.2478/v10163-010-0003-8 ACTA CHIRURGICA LATVIENSIS 2009 (9 ) ORIGINAL ARTICLE First Experience in Qulity of Life Anlysis After Britric Surgery Arturs Ozolins*,**, Mris Pvrs*, Jnis Grdovskis*,**

More information

Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study

Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study Journl of Heptology 37 (2002) 78 86 www.elsevier.com/locte/jhep Improved prognosis of postopertive heptocellulr crcinom ptients when treted with functionl foods: prospective cohort study Yoichi Mtsui*,

More information

Anemia in pediatric hemodialysis patients: Results from the 2001 ESRD Clinical Performance Measures Project

Anemia in pediatric hemodialysis patients: Results from the 2001 ESRD Clinical Performance Measures Project Kidney Interntionl, Vol. 64 (2003), pp. 1120 1124 Anemi in peditric hemodilysis ptients: Results from the 2001 ESRD Clinicl Performnce Mesures Project DIANE L. FRANKENFIELD, ALICA M. NEU, BRADLEY A. WARADY,

More information

Optimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality

Optimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality Optimistion of diets for Atlntic cod (Gdus morhu) roodstock: effect of rchidonic cid on egg & lrvl qulity Dr Gordon Bell, Ms. An Blnco, Dr Bill Roy, Dr Derek Roertson, Dr Jim Henderson nd Mr Richrd Prickett,

More information

One of the most important biological mechanisms of

One of the most important biological mechanisms of Brief Report Serum Thymidine Kinse 1 Activity in the Prognosis nd Monitoring of Chemotherpy in Lung Cncer Ptients: A Brief Report Benjmin Nismn, PhD,* Hovv Nechushtn, MD, PhD,* Him Birn, MD, Hds Gntz-Sorotsky,

More information

Handgrip exercise elevates basilic venous hemodynamic parameters in healthy subjects

Handgrip exercise elevates basilic venous hemodynamic parameters in healthy subjects interntionl journl of nursing sciences 1 (2014) 389e393 Avilble online t www.sciencedirect.com ScienceDirect journl homepge: http://www.elsevier.com/journls/interntionljournl-of-nursing-sciences/2352-0132

More information