Penumbra INTRACRANIAL ACCESS REDEFINED

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1 Penumbra INTRACRANIAL ACCESS REDEFINED

2 BENCHMARK Case Examples Stability & Compatibility Atraumatic Navigation Flow Diverter Delivery Pipeline BENCHMARK Stability Without Surpass Full distal shaft radiopacity BENCHMARK Neuron MAX Balloon Coiling of Ruptured ACOM Aneurysm Performance Testing Distal Purchase for Basilar Tip Aneurysm Coiling Compatible With Neuron MAX for Added Support Designed to Maximize Arch Support A New Level of Tip Softness More Support Force (g) g 58g 40g 33g Softer Force (g) g 50g 56g 64g Benchmark 071 Envoy XB Neuron 070 Navien Benchmark 071 Neuron 070 Envoy DA Navien 072 Buckling Test: Higher values correspond with more proximal support 1 Deflection Test: Lower values correspond to softer distal tip 2 1. Data on fi le at Penumbra, Inc. 2. Data on fi le at Penumbra, Inc.

3 BENCHMARK 071: Built with ACE technology Advanced Polymer: Enables easy navigation and excellent visibility Polished, Atraumatic Tip: Optimized for safe placement into distal anatomy 10 Material Transitions: Efficient energy transfer for optimal trackability Hybrid Flat/Round Metal Reinforcement: Enables both arch support and tortuous navigation Proximal Shaft Construction: Provides extra stability even when left lower than expected 6F outer diameter.071" lumen

4 BENCHMARK 071 is Now Packaged with a 5F Penumbra Select Catheter Advantages of Select Technology Faster procedures no need for an exchange Allows easy selection off of arch into desired vessel, and immediate final placement Facilitates atraumatic placement into distal vasculature Can be used for diagnostic angiogram.040" lumen Compatible with all.035".038" guidewires Preload BENCHMARK 071 guide catheter with 5F Penumbra Select catheter of desired shape. Seamless transition zone with no shelf for atraumatic advancement. Primary Access Delivery Technique BENCHMARK 071 5F Penumbra Select Catheter BENCHMARK F Penumbra Select Catheter Introduce the preloaded system over a guidewire and advance to a straight section of the abdominal aorta. Advance the tip of Select over the guidewire into the ascending aorta while maintaining the position of BENCHMARK 071. Advance Select and Benchmark 071 over the guidewire into the internal carotid artery. With sufficient wire purchase, torque Select catheter towards the first major turn. While maintaining position of Select and guidewire, advance BENCHMARK 071 into desired position. Remove Select while holding BENCHMARK 071 in position.

5 BENCHMARK 071 5F Select Description Length Shape Length Shape BMK6F95BER120 BENCHMARK 071 KIT 95 cm Straight 120 cm BER BMK6F95MBER120 BENCHMARK 071 KIT 95 cm MP 120 cm BER BMK6F105BER130 BENCHMARK 071 KIT 105 cm Straight 130 cm BER BMK6F105MBER130 BENCHMARK 071 KIT 105 cm MP 130 cm BER BMK6F95 BENCHMARK cm Straight BMK6F95M BENCHMARK cm MP BMK6F105 BENCHMARK cm Straight BMK6F105M BENCHMARK cm MP Working Inner Wire Description Length Diameter Compatibility Shape PNS5F120BER 5F Select Catheter 120 cm.040".035 /.038" BER PNS5F130BER 5F Select Catheter 130 cm.040".035 /.038" BER PNS5F130SIM 5F Select Catheter 130 cm.040".035 /.038" SIM PNS5F120H1 5F Select Catheter 120 cm.040".035 /.038" H1 PNS5F130H1 5F Select Catheter 130 cm.040".035 /.038" H1 PNML6F PNML6F088804M PNML6F PNML6F088904M Description 6F 088 Neuron MAX Working Length Distal Flexible Zone Inner Diameter Wire Compatibility Shape 80 cm 4 cm.088".035 /.038" Straight 80 cm 4 cm.088".035 /.038" MP 90 cm 4 cm.088".035 /.038" Straight 90 cm 4 cm.088".035 /.038" MP Working Proximal Distal Effective Total Description Length OD OD Flow Lumen Length 5MAXDDC115 5MAX Distal Delivery Catheter 115 cm 6.0F (.080") 5F.062" 119 cm 5MAXDDC125 5MAX Distal Delivery Catheter 125 cm 6.0F (.080") 5F.062" 129 cm 4MAXDDC130 4MAX Distal Delivery Catheter 130 cm 6.0F (.080") 4.3F.053" 134 cm BENCHMARK 071 Select Catheter

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