Endoanchor-assisted TEVAR
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1 Endoanchor-assisted TEVAR May 29, 2015 NCVH2015 Grayson H. Wheatley III, MD Director of Aortic and Endovascular Surgery Associate Professor of Surgery Temple University School of Medicine
2 Disclosures Consultant Medtronic Bolton Medical TriVascular Lombard Medical Aptus
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4 Imaging revolution Treatment revolution catalyst
5 Endoleaks happen Even with optimal planning Even with current stent-graft technologies
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8 Challenges in TEVAR High anatomical variations Deployment challenges & risks, e.g. birdbeaking Manipulations near or coverage of critical branches Risk of neurologic complications or mesenteric ischemia Larger devices in smaller anatomy (higher rate of females) Higher risk of access complications Beat-to-beat movement Risk of migration/leak and progression of TAA FJ Criado, The TEVAR Landscape in Dec 2011 Endovascular Today
9 Securing Endografts in the Thoracic Aorta Dynamic environment Difference in compliance of aorta Pulsating forces Longitudinal Lateral Rotational
10 Securing Endografts in the Thoracic Aorta
11 Most Common Endoleaks in TEVAR are Type I Endoleaks Over Time Makaroun et al. JVS 2008 Periop 1 mo 6 mo 12 mo 24 mo 36 mo 48 mo 60 mo Patients available for F/U Patients with endoleaks 7 (8.6%) 10 (8.1%) 7 (6.5%) 4 (3.9%) 5 (6.3%) 2 (3.1%) 3 (5.3%) 2 (4.3%) Type Ia Type Ib Type II Type III Type IV Indeterminate Image from article: Endoleaks after endovascular repair of thoracic aortic aneurysms. Parmer et. al. J Vasc Surg 2006;44 Image from article: Outcome of endovascular treatment of traumatic aortic transection, Steuer et. al. JVS 2012;56 11
12 Re-interventions after TEVAR Remain High 1 Re-intervention rates not resolved in newer generation grafts Re-intervention rate by time period % % % Overall reinterventions: 22% Major indication for re-intervention is Type I EL 8.3% type I endoleak related re-interventions Re-intervention Indication Type I endoleak 8.3% Type II endoleak 1.5% Subclavial steal syndrome Endograft compression/collapse Aortobronchial/ esophageal fistula Overall Incidence 1.5% 1.1% 1.1% Type III endoleak 0.4% Endograft infection 0.4% 1 Geisbüsch P. et al. JVS 2011;53:1528. (Heidelberg) 12
13 Revision TAA Proximal Type 1 endoleak Images Courtesy: Grayson Wheatley MD Temple University
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15 Role of Heli-FX Thoracic EndoAnchor System in TEVAR Enhances sealing & fixation of endografts Simplifies revisions for endograft migration and Type I endoleak Enables tailoring of endograft apposition & fixation to patient anatomy 15
16 Primary TAA with Short/Angled Proximal Neck 4 EndoAnchors implanted in outer & inner radius of proximal neck Case images courtesy of Thomas Naslund, MD Vanderbilt University Medical Center 16
17 Multiple Deflection Lengths for Varying Neck Diameters Aptus Heli-FX Thoracic EndoAnchor System 18Fr OD, 90cm working length 22, 32, 42mm Tip Lengths Aptus Heli-FX EndoAnchor System 16Fr OD, 62cm working length 22 & 28mm Tip Lengths 17
18 Limitations of EndoAnchors Mural thrombus >2mm thick and 180º of circumference Porcelain aorta (severe circumferential calcification) Loss of graft apposition with resulting gap Excessive Thrombus in Aorta Excessive Calcification in Aorta Attaching endograft layers without aortic wall penetration Aorta dilated beyond endograft 18
19 Early Published European TEVAR Experience 1 Kasprzak et al. used EndoAnchors to repair incomplete sealing and non-alignment of TAA/TAAA grafts 4 pts - revision setting 2 pts - primary setting for acute complications Indications: type Ia/Ib EL, graft migration, graft infolding EndoAnchor implantation and fixation successful in all patients No EndoAnchors misdeployed No other adjunctive maneuvers needed after EndoAnchors Favorable follow-up in mean 11-month No stent-graft migration, type I endoleak or EndoAnchor dislocation observed 1 Kasprzak et al. J Endovasc Ther Aug;20(4). 19
20 TEVAR + Endoleaks Treatment Prevention
21 TEVAR + Endoleaks Aortic Arch Distal Segment Treatment Prevention
22 Commit to the curve
23 Why Endostapling in this Case? Preventive Gothic Arch Type III arch Short proximal neck Avoid windsocking of graft while ballooning proximal neck Prevent graft migration Prevent neck dilation?
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26 EndoAnchor Clinical Experience in TEVAR 1 >200 total TEVAR cases with EndoAnchors since June-2013 launch Breakdown of TEVAR cases* Majority cases in Primary setting No reported late Anchor Dislocations, Fractures or Fistula Hostile necks in Primary and Type I endoleaks in Revision are most common cited reasons for EndoAnchoring Primary 68% Revision 32% PRIMARY SETTING Reason Frequency* Short neck 47.9% Angulated neck 15.5% REVISION SETTING Reason Frequency* Late type % Migration 21.1% Cook TX2 14% Types of Grafts* Other 3% Wide neck 15.5% Conical neck 12.7% Acute type 1 8.5% Neck dilatation 15.8% Gore TAG 27% Medtronic Valiant 56% 1 Per data on file at Aptus * Reflects EndoAnchor TEVAR use in the US 26
27 EndoAnchors: When to Consider? Severe Angulation Migration/ Type 1 Leak Primary Difficult landing Revision Birdbeaking Hostile Necks Case images courtesy of P Kasprzak MD, Regensburg and JM Panneton, Eastern Virgina Medical Lower image from R. Kolvenbach et al. J Vasc Bras. 2009;8(4) Type 1 Leak image courtesy of P Kasprzak MD, Regensburg, birdbeaking image from Tadros et al, JVS 2011:53 27
28 65-year-old white male Prior open AAA repair 6.5 cm aneurysm of lower descending thoracic aorta 5cm aneurysm of proximal descending thoracic aorta
29 Celiac artery
30 Valiant 44 x 100 proximal main graft Valiant 46 x 100 distal main graft
31 Valiant 44 x 100 proximal main graft Valiant 46 x 100 distal main graft
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34 Conclusions Strong need for EndoAnchors in TEVAR Addresses major cause of complications by potentially reducing neck dilatation and realignment risks Treats seal complications and may mitigate risk of further complications Provides a solution for challenging anatomy and often compromised seal zones Clinical experience (>200 pts) confirms EndoAnchor use is safe No reported late Anchor Dislocations, Fractures or Fistula Preliminary results show promise in preventing and treating sealrelated complications Primary TEVAR: challenging proximal and/or distal neck, acute type I endoleak Revision TEVAR: late type I endoleak, graft migration, graft in-folding 34
35 Endoanchor-assisted TEVAR May 29, 2015 NCVH2015 Grayson H. Wheatley III, MD Director of Aortic and Endovascular Surgery Associate Professor of Surgery Temple University School of Medicine
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