CURRICULUM VITAE. Yuan Lin, M.D., Ph.D.

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1 CURRICULUM VITAE Yuan Lin, M.D., Ph.D. Visiting Assistant Professor, Epidemiology Richard M. Fairbanks School of Public Health, Indiana University Health Sciences Building (RG) Wishard Blvd. Indianapolis IN Mobile: (317) EDUCATION Ph.D. (Epidemiology and Biostatistics) Nanjing Medical University, Nanjing, China Major: Molecular Epidemiology of Complex Diseases Advisor: Prof. Zhibin Hu (University Vice President, Former Dean of School of Public Health) M.D. (Medicine) Nanjing Medical University, Nanjing, China Sep Jul Sep Jul RESEARCH AREA Genetic Epidemiology, Plasma Biomarkers, Cancer and Congenital diseases PROFESSIONAL AND RESEARCH EXPERIENCE Visiting Assistant Professor (Epidemiology) Richard M. Fairbanks School of Public Health, Indiana University Aug present Scientific & Management Responsibilities: 1) Conducting statistical data analyses of large genomic data and TCGA data 2) Preparing research proposals for submission to various grant funding agencies 3) Preparing manuscripts for peer reviewed journals and presenting findings at selected conference genes and cancer risk Special Volunteer in the NIH Visiting Program (Epidemiology) Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Supervisor: Dr. Cuilin Zhang Jun Apr

2 Scientific & Management Responsibilities: 1) Studied the roles of genetic factors and biomarkers in the pathogenesis of gestational diabetes and fetal growth 2) Led research project Association Analysis of Telomere Length and Risk of Gestational Diabetes 3) Led research project Plasma acylcarnitines and Risk of Gestational Diabetes 4) Actively involved in other aspects of related research projects such as administrative support and manuscript preparation Postdoctoral Fellow (Epidemiology) Richard M. Fairbanks School of Public Health, Indiana University Supervisor: Dr. Jiali Han Mar Jun Scientific & Management Responsibilities: 1) Performed data analysis and manuscript preparation for Genome-wide Association Studies 2) Designed and led several studies of genetic variation in important pathway genes and cancer risk TEACHING EXPERIENCE Introduction to Genetics for Chronic Disease (Undergraduate Course, Prof. Timothy D. McFarlane) Introduction to Genetic Epidemiology Method (Undergraduate Course, Prof. Timothy D. McFarlane) 02/18/ /23/2017 FUNDING Participation, State Key Program of National Natural Science, China The role and underlying mechanisms of protein phosphorylation in human spermatogenesis Participation, State General Program of National Natural Science, China Genome-wide association and functional analysis for ventricular septal defect in Han Chinese populations Participation, Innovative Team of Qing Lan Project, China Study on Etiologies of Birth Defects

3 HONORS AND AWARDS Nanjing Medical University First Prize Scholarship Fei Xiao-tong Exceptionally Outstanding Medical Student Scholarship National Scholarship for Graduate Students INVITED PRESENTATION Genome-Wide Association Analysis of Congenital Heart Disease: Identification of Novel Risk Loci in Chinese Population Zhang-jiajie, China, the 14th Academic Exchange on Reproduction Biology Branch of China Zoology Biology Institute A Prospective Study of Plasma Acylcarnitines and Risk of Gestational Diabetes in a Multi-racial Pregnancy Cohort San Diego, California, the American Diabetes Association s (ADA) 77th Scientific Sessions Seattle, WA, the 30th Annual Meeting of the Society for Pediatric and Perinatal Epidemiologic Research (SPER) AD HOC REVIEWER FOR JOURNALS 1. Internal Journal of Epidemiology 2. Causes and Control 3. Human Genetics 4. PloS One 5. The Journal of Nutrition 6. The Cleft Palate-Craniofacial Journal 7. Scientific Reports 8. Journal of the American Society of Nephrology 9. Journal of the Academy of Nutrition 10. BMC Nutrition 11. Journal of Photochemistry & Photobiology 12. Journal of Investigative Dermatology PUBLICATIONS 1. Lin Y, Chahal HS, Wu W, Cho HG, Ransohoff KJ, Song F, Tang JY, Sarin KY, Han J.Association study of genetic variation in DNA repair pathway genes and risk of basal cell carcinoma. Int J Cancer Sep 1;141(5):

4 2. Lin Y, Chahal HS, Wu W, Cho HG, Ransohoff KJ, Dai H, Tang JY, Sarin KY, Han J. Association between genetic variation within vitamin D receptor-dna binding sites and risk of basal cell carcinoma. Int J Cancer May 1;140(9): Chahal HS*, Lin Y*, Ransohoff KJ, Hinds DA, Wu W, Dai HJ, Qureshi AA, Li WQ, Kraft P, Tang JY, Han J, Sarin KY. Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma. Nat Commun 2016 Jul 18;7: (*cofirst 4. Lin Y*, Guo X*, Zhao B*, Liu J*, Da M*, Wen Y, Hu Y, Ni B, Zhang K, Yang S, Xu J, Dai J, Wang X, Xia Y, Ma H, Jin G, Yu S, Liu J, Keavney BD, Goodship JA, Cordell HJ, Wang X, Shen H, Sha J, Zhou Z, Chen Y, Mo X, Luo L1, Hu Z. Association analysis identifies new risk loci for congenital heart disease in Chinese populations. Nat Commun Aug 18;6:8082. (*co-first 5. Lin Y*, Ding C*, Zhang K, Ni B, Da M, Hu L, Hu Y, Xu J, Wang X, Chen Y, Mo X, Cui Y, Shen H, Sha J, Liu J, Hu Z. Evaluation of regulatory genetic variants in POU5F1 and risk of congenital heart disease in Han Chinese. Sci Rep Oct 28;5: (*co-first 6. Lin Y*,, Zhu Y, Wu J, Hinkle SN, Rawal S, Han J, Weir N, Tsai MY, Zhang C A Prospective Study of Leukocyte Telomere Length and Risk of Gestational Diabetes in a Multiracial Cohort. Epidemiology (accepted) 7. Hu Z*, Shi Y*, Mo X*, Xu J*, Zhao B*, Lin Y*, Yang S, Xu Z, Dai J, Pan S, Da M, Wang X, Qian B, Wen Y, Wen J, Xing J, Guo X, Xia Y, Ma H, Jin G, Yu S, Liu J, Zhou Z, Wang X, Chen Y, Sha J, Shen H.A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations. Nat Genet Jul; 45(7): (*co-first 8. Hu Z*, Li Z*, Yu J*, Tong C*, Lin Y*, Guo X*, Lu F, Dong J, Xia Y, Wen Y, Wu H, Li H, Zhu Y, Ping P, Chen X, Dai J, Jiang Y, Pan S, Xu P, Luo K, Du Q, Yao B, Liang M, Gui Y, Weng N, Lu H, Wang Z, Zhang F, Zhu X, Yang X, Zhang Z, Zhao H, Xiong C, Ma H, Jin G, Chen F, Xu J, Wang X, Zhou Z, Chen ZJ, Liu J, Shen H, Sha J. Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men. Nat Commun May 23; 5:3857. (*co-first 9. Ni B*, Lin Y*, Sun L, Zhu M, Li Z, Wang H, Yu J, Guo X, Zuo X, Dong J, Xia Y, Wen Y, Wu H, Li H7, Zhu Y, Ping P, Chen X, Dai J, Jiang Y, Xu P, Du Q, Yao B, Weng N, Lu H, Wang Z, Zhu X, Yang X, Xiong C, Ma H, Jin G, Xu J, Wang X, Zhou Z, Liu J, Zhang X, Conrad DF, Hu Z, Sha J.Low-frequency germline variants across 6p22.2-6p21.33 are associated with nonobstructive azoospermia in Han Chinese men. Hum Mol Genet Jul 21. pii: ddv257. (*co-first 10. Zhao B*, Lin Y*, Xu J, Ni B, Da M, Ding C, Hu Y, Zhang K, Yang S, Wang X, Yu S, Chen Y, Mo X, Liu J, Shen H, Sha J, Ma H. Replication of the 4p16 Susceptibility Locus in Congenital Heart Disease in Han Chinese Populations. PLoS One Sep 12;9(9):e (*cofirst 4

5 11. Xu J*, Lin Y*, Si L, Jin G, Dai J, Wang C, Chen J, Da M, Hu Y, Yi C, Hu Z, Shen H, Mo X, Chen Y, Wang X. Genetic variants at 10p11 confer risk of Tetralogy of Fallot in Chinese of Nanjing. PLoS One Mar 3; 9(3):e (*co-first 12. Ji G*, Lin Y*, Cao S, Li L, Chen X, Sun B, Chen C, Ma H XPC 939A>C and 499C>T polymorphisms and skin cancer risk: a meta-analysis. Asian Pac J Cancer Prev. 2012; 13(10): (*co-first 13. Panuganti PL, Hinkle SN, Rawal S, Grunnet LG, Lin Y, Liu A, Thuesen ACB, Ley SH, Olesen SF, Zhang C. Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes. Nutrients Jul 21;10(7). 14. Ding M, Chavarro J, Olsen S, Lin Y, Ley SH, Bao W, Rawal S, Grunnet LG, Thuesen ACB, Mills JL, Yeung E, Hinkle SN, Zhang W, Vaag A, Liu A, Hu FB, Zhang C. Genetic variants of gestational diabetes mellitus: a study of 112 SNPs among 8722 women in two independent populations. Diabetologia Aug;61(8): Rawal S, Tsai MY, Hinkle SN, Zhu Y, Bao W, Lin Y, Panuganti P, Albert PS, Ma RCW, Zhang C. A Longitudinal Study of Thyroid Markers Across Pregnancy and the Risk of Gestational Diabetes. J Clin Endocrinol Metab Jul 1;103(7): Chahal HS, Wu W, Ransohoff KJ, Yang L, Hedlin H, Desai M, Lin Y, Dai HJ, Qureshi AA, Li WQ, Kraft P, Hinds DA, Tang JY, Han J, Sarin KY. Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Nat Commun Aug 19;7: Ransohoff KJ, Wu W, Cho HG, Chahal HC, Lin Y, Dai HJ, Amos CI, Lee JE, Tang JY, Hinds DA6, Han J, Wei Q, Sarin KY. Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Oncotarget Mar 14;8(11): Lu C, Jiang J, Zhang R, Wang Y, Xu M, Qin Y, Lin Y, Guo X, Ni B, Zhao Y, Diao N, Chen F, Shen H, Sha J, Xia Y, Hu Z, Wang X. Gene copy number alterations in the azoospermiaassociated AZFc region and their effect on spermatogenic impairment. Mol Hum Reprod Sep;20(9): Lu C, Wen Y, Hu W, Lu F, Qin Y, Wang Y, Li S, Yang S, Lin Y, Wang C, Jin L, Shen H, Sha J, Wang X, Hu Z, Xia Y. Y chromosome haplogroups based genome-wide association study pinpoints revelation for interactions on non-obstructive azoospermia. Sci Rep Sep 15;6: Zhang Y, Qian J, Wu M, Liu M, Zhang K, Lin Y, Guo X, Zhou Z, Hu Z, Sha J. A susceptibility locus rs is associated with non-obstructive azoospermia via reduction in the expression of FAM160B1. J Biomed Res Nov;29(6): Ni B, Ma H, Lin Y, Dai J, Guo X, Xia Y, Sha J, Hu Z. Genetic variants in Ser-Arg proteincoding genes are associated with the risk of nonobstructive azoospermia in Chinese men. Fertil Steril Jun; 101(6): e Huang N, Wen Y, Guo X, Li Z, Dai J, Ni B, Yu J, Lin Y, Zhou W, Yao B, Jiang Y, Sha J, Conrad DF, Hu Z. A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Non-Obstructive Azoospermia in Humans. Biol Reprod Jul 22. pii: biolreprod

6 23. Wang Q, Liu C, Tang C, Guo H, Liu Y, Wang L, Zhao H, Shang Y, Wen Y, Lin Y, Zhou T, Zhou Z, Dong W, Hu Z, Guo X, Sha J, Li W. et al. Yeast model identifies ENTPD6 as a potential nonobstructive azoospermia pathogenic gene. Sci Rep Jul 8;5: Yu J, Wu H, Wen Y, Liu Y, Zhou T, Ni B, Lin Y, Dong J, Zhou Z, Hu Z, Guo X, Sha J, Tong C. Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Hum Mol Genet Mar 1;24(5): Da M, Feng Y, Xu J, Hu Y, Lin Y, Ni B, Qian B, Hu Z, Mo X. Association of aminoacyl-trna synthetases gene polymorphisms with the risk of congenital heart disease in the Chinese Han population. PLoS One Oct 13;9(10):e Feng Y, Yu D, Yang L, Da M, Wang Z, Lin Y, Ni B, Wang S, Mo X. Maternal lifestyle factors in pregnancy and congenital heart defects in offspring: review of the current evidence. Ital J Pediatr Nov 11;40: Liu Y, Ni B, Lin Y, Chen XG, Chen M, Hu Z, Zhang F. The rs G/A Polymorphism in CAV1 is Associated with the Risk of Atrial Fibrillation in Chinese Han Populations. Pacing Clin Electrophysiol Feb;38(2): Liu Y, Ni B, Lin Y, Chen XG, Fang Z, Zhao L, Hu Z, Zhang F. Genetic polymorphisms in ZFHX3 are associated with atrial fibrillation in a Chinese Han population. PLoS One Jul 1;9(7):e Qian Y, Liu S, Lu F, Li H, Dong M, Lin Y, Du J, Lin Y, Gong J, Jin G, Dai J, Hu Z, Shen H. Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese. BMC Genet Sep 22; 14: Lu F, Qian Y, Li H, Dong M, Lin Y, Du J, Lin Y, Chen J, Shen C, Jin G, Dai J, Hu Z, Shen H. Genetic variants on chromosome 6p21.1 and 6p22.3 are associated with type 2 diabetes risk: a case-control study in Han Chinese. J Hum Genet May; 57(5):