Robert Fischer Fertility Centre Hamburg Hamburg, Germany

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1 EXCEMED Blended Education Improving success in ART: how to define it and key strategies to get the best outcomes Live intervention in Beijing, China PRELIMINARY PROGRAMME

2 Improving success in ART: how to define it and key strategies to get the best outcomes Overview Controlled ovarian stimulation (COS) now plays a major role in optimising IVF outcomes by facilitating control of different aspects of the process and increasing the number of oocytes available. COS aims to achieve maximal success with minimal side effects. Progress in and understanding of ovarian physiology, as well as new advances in ovarian stimulation strategies have made it possible for healthcare professionals to achieve the optimal outcomes for patients. Success in assisted reproductive technology (ART) depends on carefully controlled conditions in every step of the laboratory routine. In addition, continuous advances in technology require constant revision of good laboratory practices and the introduction of new techniques. This educational activity will improve the participants knowledge of the latest technologies and laboratory practice guidelines. The learning activity offers an interactive programme with specialised lectures tailored to fit the needs of physicians and embryologists working in ART, followed by lectures and case studies. Learners will have the opportunity to discuss, directly with renowned scientists, pertinent topics that have been the subject of controversy and innovation. Discussions will concentrate on how to facilitate optimal laboratory conditions, culture environments, selection criteria and how to select the best therapy for infertile patients. Learning objectives By completing this educational activity, you will be able to: Appraise laboratory and clinical outcomes and their relationship to defining success in ART Define key factors influencing the success of ART Tailor the best stimulation protocol for the patient undergoing ART Discuss and debate changing approaches to ART Target audience This programme is designed for clinicians and biologists working in assisted reproductive medicine, who want to acquire up-to date information for improving their current practice. Chair Robert Fischer Fertility Centre Hamburg Hamburg, Germany An EXCEMED Learning Journey The EXCEMED blended education approach reinforces concepts from different angles using diverse formats which reinforce the learning experience. A multistep approach is used, encompassing webbased and live activities. All activities in-person and online involves the full interactivity of learners. At three stages throughout the process, you will be asked to give your feedback on the learning experience through the 3 surveys. The aim of this learner-centred programme is to enhance clinical practice by exploring the ideal outcomes desired by patients, embryologists, and clinicians following ART, with individualized approaches toward attaining these goals. After completing your Learning Journey with EXCEMED, you will receive a Diploma signed by the faculty members and a final Outcomes and Feedback Report. 2 3

3 CME Provider EXCEMED is a non profit foundation dedicated, since the last four decades, to the development of high-quality medical education programmes all over the world. EXCEMED adheres to the guidelines and standards of the European Accreditation Council for Continuing Medical Education (EACCME ) which states that continuing medical education must be balanced, independent, objective and scientifically rigorous. EXCEMED - Excellence in Medical Education Senior Programme Manager: Chloé Xilinas T chloe.xilinas@excemed.org EXCEMED adheres to the principles of the Good CME Practice group (gcmep). Register now and you will receive EXCEMED invitation to start your Learning Journey! LECTURE An introductory lecture by Sandro C. Esteves, which highlights the key points of the POSEIDON concept. This first tutorial prepares you for the live intervention lecture on POSEIDON in Beijing, and will enable you to: Grasp the latest scientific advances in the field of impaired response to ovarian stimulation Understand the new low prognosis concept and its application in clinical practice Individualize and manage women with expected or unexpected low ovarian response to ART according to the POSEIDON classification LIBRARY The second tutorial augments the content of the intervention and gives you the information you need to be fully engaged with the live intervention. You are also able to share your research and publications with the rest of the community using the library platform, and submit any questions you have to the faculty ahead of the meeting, which will be answered during the live intervention panel discussion. Features of the interactive library: Literature corner: summarises the key points and related publications for each of the lectures being presented during the live intervention in Beijing. Publications exchange: contains a section for learners to share their research and publications related to the educational activity topics. Question time: is a chance for leaners to ask questions anonymously the faculty will answer them during the live intervention. The tutorial helps you to: Find the latest information on protocols and techniques and keep up-to-date with advances in ART procedures Share best practices with colleagues and therefore improve patient management Access information from the leading experts in the field 4 5

4 FACULTY The live component of the Learning Journey begins with a 30-minute roundtable discussion, allowing you and experts to engage with one another prior to the plenary sessions. Faculty members presents their scientific material using a combination of lectures, panel discussions and case studies. You are notified via when the video lectures, slide kits and a scientific highlights publication from the live intervention is available online. Venue This live intervention will take place at the: COURTYARD BEIJING NORTHEAST 101 Jingmi Road, Chaoyang District Beijing China Language The official language of this live intervention will be English. Continuing Medical Education An application has been made to the EACCME for CME accreditation of the EXCEMED workshop Improving success in ART: how to define it and key strategies to get the best outcomes to be held on in Beijing, China. Giovanni Coticchio BIOGENESI, Reproductive Medicine Centre Monza, Italy Robert Fischer Fertility Centre Hamburg Hamburg, Germany Sesh Kamal Sunkara Reproductive Medicine Unit Queen's Hospital Essex, UK Christos A. Venetis Women's and Children's Health St George Hospital University of New South Wales Sydney, Australia Peng Cheang Wong Yong Loo Lin School of Medicine National University of Singapore National University Health System Singapore, Republic of Singapore 6 7

5 PROGRAMME Saturday, Registration Opening and introduction R. Fischer (Germany) Session I L1: What is success in ART? P.C. Wong (Singapore) Question time P.C. Wong (Singapore) L2: The importance of oocyte numbers for cumulative live-birth rates S.K. Sunkara (UK) Question time S.K. Sunkara (UK) Panel discussion Coffee break L3: How to define subgroups for COS? C.A. Venetis (Australia) Question time C.A. Venetis (Australia) L4: What kind and dose of gonadotropins to use in COS? C.A. Venetis (Australia) Question time C.A. Venetis (Australia) Panel discussion Lunch Session II L5: From poor response to low prognosis: The POSEIDON concept R. Fischer (Germany) Question time R. Fischer (Germany) L6: The role of recent advancement in laboratory technology to improve ART outcome (Time Lapse; Vitrification) G. Coticchio (Italy) Question time G. Coticchio (Italy) Panel discussion Coffee break L7: The role of pre-implantation testing for aneuploidy to improve selection What are the limits? G. Coticchio (Italy) Question time G. Coticchio (Italy) L8: Is the time ready for freeze-all strategy for all patients? What is the best frozen embryo transfer protocol? S.K. Sunkara (UK) Question time S.K. Sunkara (UK) Panel discussion Concluding remarks R. Fischer (Germany) End of the live intervention Legend: L : Lecture : Question time : Panel discussion 8 9

6 Registration Continue your Learning Journey after the live intervention! VIDEO INTERVIEW In the third tutorial, watch Peng Cheang Wong consider what defines success in assisted reproductive technology. INTERACTIVE CLINICAL CASE Online post event tutorials helps you delve deeper into content and test yourself with an interactive clinical case study exploring the POSEIDON criteria. The last tutorial helps you to: Understand why testicular sperm may lead to better ART outcomes than ejaculated sperm, and when sperm DNA fragmentation (SDF) is indicated Determine which genetic evaluations are available for low prognosis patients and when to use them Grasp how to use the ART Online Calculator to estimate the number of oocytes needed to obtain at least one euploid blastocyst The registration fee for the whole blended programme is EURO 150,00 and includes: Access to the online tutorials Scientific sessions Coffee breaks and luncheons Educational materials Certificate of attendance Dinners are not included For registration, accommodation and any logistic inquiry, please contact: Meridiano Congress International Congress Manager: Titty Alvino T F titty.alvino@meridiano.it Visit Follow us on 10 11

These views are the responsibility of the named speakers, and do not represent an endorsement or recommendation on the part of EXCEMED.

7 All EXCEMED programmes are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted. There may be presentations discussing investigational uses of various products. These views are the responsibility of the named speakers, and do not represent an endorsement or recommendation on the part of EXCEMED. This independent programme is made possible thanks to educational grants received from: Ferty School, MVZ Fertility Center Hamburg, Istituto di Ricerche Genetiche, Merck KGaA Darmstadt Germany and San Raffaele Hospital Milan

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Target audience. Chair. Robert Fischer Fertility Centre Hamburg Hamburg, Germany

Target audience. Chair. Robert Fischer Fertility Centre Hamburg Hamburg, Germany EXCEMED Blended Education Ovarian stimulation strategies: maximizing efficiency in ART Live intervention in Rio de Janeiro, Brazil PRELIMINARY PROGRAMME Ovarian stimulation strategies: maximizing efficiency