Date Printed: 03/10/2011 Date Updated: 07/25/2007 Version 1.9. VANADIUM(V) OXIDE EXTRA PURE Product Number 14205

Transcription

1 SIGMA-ALDRICH MATERIAL SAFETY DATA SHEET Date Printed: 03/10/2011 Date Updated: 07/25/2007 Version 1.9 Section 1 - Product and Company Information Product Name VANADIUM(V) OXIDE EXTRA PURE Product Number Brand RIEDEL Company Address Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO US Technical Phone: Fax: Emergency Phone: Section 2 - Composition/Information on Ingredient Substance Name CAS # SARA 313 VANADIUM (V) OXIDE Yes Formula V2O5 Synonyms Anhydride vanadique (French) * C.I * Divanandium pentoxide * RCRA waste number P120 * Vanadic anhydride * Vanadio, pentossido di (Italian) * Vanadium (OSHA) * Vanadium oxide (V2O5) * Vanadium pentaoxide * Vanadiumpentoxid (German) * Vanadium pentoxide (ACGIH) * Vanadiumpentoxyde (Dutch) * Vanadium, pentoxyde de (French) * Wanadu pieciotlenek (Polish) RTECS Number: YW Section 3 - Hazards Identification EMERGENCY OVERVIEW Highly Toxic (USA) Very Toxic (EU). Dangerous for the environment. Very toxic by inhalation and if swallowed. Irritating to eyes and respiratory system. Limited evidence of a carcinogenic effect. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Possible risk of harm to the unborn child. Possible mutagen. Target organ(s): Lungs. Calif. Prop. 65 carcinogen. HMIS RATING HEALTH: 3* FLAMMABILITY: 0 REACTIVITY: 0 NFPA RATING HEALTH: 3 FLAMMABILITY: 0 REACTIVITY: 0 *additional chronic hazards present. For additional information on toxicity, please refer to Section 11.

2 Section 4 - First Aid Measures ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately. INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. DERMAL EXPOSURE In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician. EYE EXPOSURE In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician. Section 5 - Fire Fighting Measures FLASH POINT AUTOIGNITION TEMP FLAMMABILITY EXTINGUISHING MEDIA Suitable: Noncombustible. Use extinguishing media appropriate to surrounding fire conditions. FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Specific Hazard(s): Emits toxic fumes under fire conditions. Section 6 - Accidental Release Measures PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL Evacuate area. PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. METHODS FOR CLEANING UP Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. Section 7 - Handling and Storage HANDLING User Exposure: Do not breathe dust. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated exposure. STORAGE RIEDEL Page 2

3 Suitable: Keep tightly closed. Section 8 - Exposure Controls / PPE ENGINEERING CONTROLS Use only in a chemical fume hood. Safety shower and eye bath. PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Hand: Compatible chemical-resistant gloves. Eye: Chemical safety goggles. GENERAL HYGIENE MEASURES Wash contaminated clothing before reuse. Wash thoroughly after handling. EXPOSURE LIMITS, RTECS Country Source Type Value USA ACGIH TWA 0.05 MG/M3 (RESPIRABLE DUST) USA MSHA Standard-air Ceiling co0.5 MG/M3 USA OSHA. PEL CL 0.5 MG(V2O5)/M3, RESPIRABLE USA NIOSH Ceiling co0.05 MG/M3/15M EXPOSURE LIMITS Country Source Type Value Poland NDS 0.05 MG/M3 Poland NDSCh 0.5 MG/M3 Poland NDSP - Section 9 - Physical/Chemical Properties Appearance Physical State: Solid Property Value At Temperature or Pressure Molecular Weight AMU ph BP/BP Range MP/MP Range 690 C Freezing Point Vapor Pressure Vapor Density Saturated Vapor Conc. SG/Density 1.02 g/cm3 Bulk Density Odor Threshold Volatile% VOC Content Water Content Solvent Content Evaporation e Viscosity Surface Tension Partition Coefficient Decomposition Temp. Flash Point RIEDEL Page 3

4 Explosion Limits Flammability Autoignition Temp Refractive Index Optical Rotation Miscellaneous Data Solubility = not available Section 10 - Stability and Reactivity STABILITY Stable: Stable. Materials to Avoid: Strong acids. HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Nature of decomposition products not known. HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur Section 11 - Toxicological Information ROUTE OF EXPOSURE Skin Contact: May cause skin irritation. Skin Absorption: Skin absorption may occur. May be harmful if absorbed through the skin. Eye Contact: Causes eye irritation. Inhalation: Material is irritating to mucous membranes and upper respiratory tract. Highly toxic by inhalation. Ingestion: Highly toxic by ingestion. SENSITIZATION Sensitization: Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals. TARGET ORGAN(S) OR SYSTEM(S) Lungs. SIGNS AND SYMPTOMS OF EXPOSURE Repeated exposure may result in a greenish discoloration of the tongue and may result in sensitivity to vanadium and its compounds. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. TOXICITY DATA Oral 10 mg/kg Remarks: Behavioral:Coma. Inhalation 126 mg/m3 LC50 Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Other. Behavioral:Ataxia. Lungs, Thorax, or RIEDEL Page 4

5 Respiration:Dyspnea. Intraperitoneal 12 MG/KG Subcutaneous 14 MG/KG Remarks: Behavioral:Coma. Intratracheal 6 MG/KG Oral Mouse 5 mg/kg Intraperitoneal Mouse 23 MG/KG Subcutaneous Mouse 10 MG/KG Skin Rabbit 50 mg/kg Remarks: Kidney, Ureter, Bladder:Other changes. Liver:Other changes. IRRITATION DATA Eyes Rabbit 20 mg 24H Remarks: Moderate irritation effect ACGIH CARCINOGEN LIST ing: A4 CHRONIC EXPOSURE - TERATOGEN Result: Possible risk of congenital malformation in the fetus. Species: Dose: 180 MG/KG Route of Application: Oral Result: Effects on Embryo or Fetus: Other effects to embryo. Species: RIEDEL Page 5

6 Dose: 50 MG/KG Result: Specific Developmental Abnormalities: Musculoskeletal system. Specific Developmental Abnormalities: Other developmental abnormalities. Specific Developmental Abnormalities: Skin and skin appendages. Species: Dose: 5 MG/KG Exposure Time: (10D PREG) Result: Specific Developmental Abnormalities: Skin and skin appendages. Specific Developmental Abnormalities: Other developmental abnormalities. Specific Developmental Abnormalities: Musculoskeletal system. Dose: 85 MG/KG Result: Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Specific Developmental Abnormalities: Musculoskeletal system. Specific Developmental Abnormalities: Other developmental abnormalities. Dose: 85 MG/KG Result: Effects on Embryo or Fetus: Other effects to embryo. Dose: MG/KG Route of Application: Intravenous Exposure Time: (8D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system. CHRONIC EXPOSURE - MUTAGEN Result: Laboratory experiments have shown mutagenic effects. Species: Human Dose: 300 NMOL/L Cell Type: leukocyte Mutation test: DNA damage Species: Human Dose: 30 UMOL/L Cell Type: lymphocyte Mutation test: DNA damage Species: Human Dose: 10 NMOL/L Cell Type: lymphocyte Mutation test: SLN Species: Hamster Dose: 1 MG/L Cell Type: lung Mutation test: Micronucleus test RIEDEL Page 6

7 CHRONIC EXPOSURE - REPRODUCTIVE HAZARD Species: Dose: 90 MG/KG Route of Application: Oral Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Effects on Embryo or Fetus: Fetal death. Species: Dose: 10 MG/KG Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Effects on Embryo or Fetus: Fetal death. Specific Developmental Abnormalities: Other developmental abnormalities. Species: Dose: 10 MG/KG Result: Effects on Fertility: Pre-implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea). Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Dose: 179 MG/KG Exposure Time: (60D MALE) Result: Effects on Fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females). Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Dose: 170 MG/KG Exposure Time: (60D MALE) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Effects on Fertility: Litter size (e.g.; # fetuses per litter; measured before birth). Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Dose: 170 MG/KG Exposure Time: (60D MALE) Result: Effects on Fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females). Paternal Effects: Testes, epididymis, sperm duct. Paternal Effects: Spermatogenesis (including genetic material, sperm morphology,motility, and count). Section 12 - Ecological Information ACUTE ECOTOXICITY TESTS RIEDEL Page 7

8 Test Type: LC50 Fish Species: Pimephales promelas (Fathead minnow) Time: 96 h Value: 1.8 mg/l Test Type: LC50 Fish Species: Onchorhynchus mykiss (Rainbow trout) Time: 96 h Value: 5.2 mg/l Test Type: EC50 Daphnia Species: Daphnia magna Time: 48 h Value: 0.94 mg/l Section 13 - Disposal Considerations APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Observe all federal, state, and local environmental regulations. Section 14 - Transport Information DOT Proper Shipping Name: Vanadium pentoxide, [non-fused form] UN#: 2862 Class: 6.1 Packing Group: Packing Group III Hazard Label: Toxic substances. PIH: Not PIH IATA Proper Shipping Name: Vanadium pentoxide IATA UN Number: 2862 Hazard Class: 6.1 Packing Group: III Section 15 - Regulatory Information EU DIRECTIVES CLASSIFICATION Symbol of Danger: T-N Indication of Danger: Toxic. Dangerous for the environment. R: 20/ /23-51/ Risk Statements: Harmful by inhalation and if swallowed. Irritating to respiratory system. Toxic: danger of serious damage to health by prolonged exposure through inhalation. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Possible risk of harm to the unborn child. Possible risk of irreversible effects. S: 36/ Safety Statements: Wear suitable protective clothing and gloves. In case of insufficient ventilation, wear suitable respiratory equipment. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid release to the environment. Refer to special instructions/safety data sheets. US CLASSIFICATION AND LABEL TEXT Indication of Danger: Highly Toxic (USA) Very Toxic (EU). RIEDEL Page 8

9 Dangerous for the environment. Risk Statements: Very toxic by inhalation and if swallowed. Irritating to eyes and respiratory system. Limited evidence of a carcinogenic effect. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Possible risk of harm to the unborn child. Safety Statements: Wear suitable protective clothing and gloves. In case of insufficient ventilation, wear suitable respiratory equipment. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid release to the environment. Refer to special instructions/safety data sheets. US Statements: Possible mutagen. Target organ(s): Lungs. Calif. Prop. 65 carcinogen. UNITED STATES REGULATORY INFORMATION SARA LISTED: Yes NOTES: This product is subject to SARA section 313 reporting requirements. TSCA INVENTORY ITEM: Yes UNITED STATES - STATE REGULATORY INFORMATION CALIFORNIA PROP - 65 California Prop - 65: This product is or contains chemical(s) known to the state of California to cause cancer. CANADA REGULATORY INFORMATION WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR. DSL: Yes NDSL: No Section 16 - Other Information DISCLAIMER For R&D use only. Not for drug, household or other uses. WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2010 Sigma-Aldrich Co. License granted to make unlimitedpaper copies for internal use only. RIEDEL Page 9