AZOOSPERMIA CYTOLOGICAL MANIFESTATIONS
|
|
- Adele Heath
- 6 years ago
- Views:
Transcription
1 ý Comptes rendus de l Académie bulgare des Sciences ÌÓÑ ÆÓ ¾¼½½ BIOLOGIE Morphologie AZOOSPERMIA CYTOLOGICAL MANIFESTATIONS Stefka Ivanova, Petia Tzvetkova (Submitted by Corresponding Member J. Jordanov on February 2, 2011) Abstract Several clinical factors for azoospermia exist. Records of semen analyses frequently contain the item round cells without further specification of the type of cells. We have investigated 1333 patients (on an average ± year-old) with congenital (n = 299), specific (n = 226) and nonspecific inflammatory (n = 390), and vascular diseases (n = 363) of male genital system and 129 (on an average ± 2.15-year-old) healthy men as a control group. The following methods were used: andrological anamnesis and status; spermatological analysis of the ejaculate and sperm morphology according to WHO [ 1 ]; cytological analysis of round cells using Papanicolaou staining technique; statistical significance was verified with Student s t-test and SPSS computer programme. Azoospermia was proved in 20.18% in all male genital pathology. Cytological analysis of type round sperm cells determined the following round cells of spermatogenic origin: spermatids 79%, spermatocytes 7%. The round cells of non-spermatogenic origin were counted: monocyte 2%, granulocyte 1%, macrophage 3%, abnormal form cells 8%. Knowledge of the clinical features and the cytological sight of azoospermia open new horizons in the treatment of infertility in some forms of azoospermia, and therefore knowledge of the specific degree of the testicular damage is a necessary step in the evaluation of azoospermic men. Key words: azoospermia, frequency, round cells, men Introduction. Several aetiologies for azoospermia exist, but the prospects of fertility in every case are very poor [ 2 4 ]. Azoospermia is found in approximately 5 20% of men evaluated for infertility [ 5, 6 ]. Records of semen analyses frequently contain the item round cells [ 7 ] without further specification of the type of cells. The round cells observed in the 1291
2 semen samples could be either of spermatogenic origin [ 8 10 ] or varying types of cells of nonspermatogenic origin [ ]. The purpose of this report is to provide an update on the clinical manifestation and frequency of azoospermia, also to investigate the cytological manifestation of such seminal plasma. Material and methods. We have investigated 1333 patients (on an average 24.81±1.90-year-old) with congenital, inflammatory and vascular diseases of male genital system and 129 (25.63 ± 2.15-year-old) healthy men as a control group (Table 1). T a b l e 1 Patients with diseases of male genital system PATIENTS WITH: CONGENITAL DISEASES OF MALE REPRODUC- TIVE SYSTEM NUMBER 299 CONGENITAL DISEASES OF TESTIS 276 Monorchism 15 Kryptorchism 148 Del-Castilo syndrome 32 Klinefelter s syndrome 81 CONGENITAL DISEASES OF EPIDIDYMIS 23 Kysta epididymis 23 INFLAMMATORY DISEASES OF MALE REPRO- DUCTIVE SYSTEM 671 SPECIFIC INFLAMMATORY DISEASES 226 Tuberculosis of genito-urinarae tract 69 Mumps orchitis 157 NONSPECIFIC INFLAMMATORY DISEASES 390 Epididymitis chronica 105 Prostatitis chronica 285 SEXUAL-TRANSMITTED INFECTION (STI) 55 VASCULAR DISEASES OF MALE REPRODUCTIVE SYSTEM 363 Varicocele 329 Torsio testis 34 CONTROL GROUP 129 We used the following methods: Andrological anamnesis and status, spermatological analysis of the ejaculate and sperm morphology according to [ 1 ]; 1292 S. Ivanova, P. Tzvetkova
3 Fig. 1. Spermatogenic cells in the seminal plasma on azoospermic men. (a e) spermatid cells; (f h) spermatocytes. Papanicolau, 600 Cytological analysis of seminal plasma, used the Papanicolaou staining to distinguish round cells of spermatogenic and nonspermatogenic origin. The following forms were identified: spermatogenic spermatogonia (dark and pale), primary spermatocytes, secondary spermatocytes, early and late spermatids (corresponding to Sa-Sb and Sc-Sd steps of spermatogenesis); nonspermatogenic round cells. Results. Cytological examination of seminal plasma in cases with azoospermia were studied. We observed cells divided into two groups (Fig. 1) spermatogenic and nonspermatogenic round cells (Fig. 2). Spermatids are the most common cell line spermatogenic (79%). As for those of nonspermatogenic origin, most common are monocytes (2%) and macrophages (3%) (Fig. 3). Discussion. Clinical manifestation and frequency of azoospermia 20.18%, described by us are not different according to other authors [ 14 16, 3, 4 ]. Inflammatory and vascular diseases of male reproductive system were very often genital pathology attended with disturbances of sperm fertilizing ability. Azoospermia was found in 20.35% on specific, 5.38% in nonspecific inflammatory Compt. rend. Acad. bulg. Sci., 64, No 9,
4 Fig. 2. Nonspermatogenic cells in the seminal plasma on azoospermic men. (a) degenerating monocyte, (b) monocyte, (c d) epithelial cells, (e) lymphocyte, (f) macrophage, (h) seminal plasma (azoospermia), (g) seminal plasma (normal, 400). Papanicolau, 600 diseases. Sexually-transmmited inflammation of male system led to 1.23% absence of spermatozoa. We proved varicocele and azoospermia in 19.72%. In our study we conducted cytological examination of seminal plasma in cases with azoospermia. Spermatids were the most frequently counted 79% of all types of cells. A number of spermatocytes in the semen is seldom accompanied by a large number of mature spermatozoa and severe disturbances of the spermatogenesis can be expected in such cases. On the other hand, degenerated spermatids are frequently observed in the presence of mature spermatozoa in the semen [ 17, 10 ]. According to Holstein and Schirren [ 9 ] abnormal form cells were detected in 50% of all cases studied. We found 8%. Atanassova and Kancheva [ 18 ] reported that chemical agents (vitamin A- deficiency), heat, and certain pathological conditions also affect selectively more differentiated germ cell stages. A differentiation of the round cells into cells of spermatogenic and nonspermatogenic origin is very important for a correct semen analysis. The lumping of 1294 S. Ivanova, P. Tzvetkova
5 Fig. 3. Frequency of nonspermatogenic cells in the seminal plasma on azoospermic men all round cells into one group (as it is suggested in many recommendations for semen analysis) highly increases the risk of misinforming the treating clinicians. Conclusion. Knowledge of the clinical features and the cytological sight of azoospermia open new horizons in the treatment of infertility in some forms of azoospermia, and therefore knowledge of the specific degree of the testicular damage is a necessary step in the evaluation of azoospermic men. REFERENCES [ 1 ] World Health Organisation (WHO). Special programme on research, development and research training in human reproduction. Annual Tech. Report., Geneva, WHO, [ 2 ] Matsumiya K., M. Namiki, S. Takahara. International Journal of Andrology, 17, 1994, No 3, [ 3 ] Popken G., J. Schwarzer. Urologie, 47, 2008, No 12, [ 4 ] Ferhi K., R. Avakian, J. Griveau, F. Guille. Andrologia, 41, 2009, No 2, [ 5 ] Jarow J., R. Oates, J. Buch, S. Shaban, M. Sigman. Urology, 49, 1992, [ 6 ] Foresta C., M. Zorzi, C. Galeazzi, M. Rossato. International Journal of Andrology, 18, 1995, [ 7 ] Johanisson E., A. Campana, R. Luthi, A. Agostini. Human Reproduction, 6, 2000, No 4, [ 8 ] Fawcett D., C. Marhert, J. Papanconstantinou. The Developmental Biology of Reproduction. New York, Academic Press, USA, 1975, Compt. rend. Acad. bulg. Sci., 64, No 9,
6 [ 9 ] Holstein A., C. Schirren, D. Fawcett, J. Bedford. The Spermatozoon: Maturation, Motility, Surfaces, Properties and Comparative Aspects. Baltimore, USA, Urban and Schwarzenberg, 1979, [ 10 ] Comhaire F., L. Vermeulen. Hum. Reprod., Update, 4, 1995, No 1, [ 11 ] Fedder J. Arch. Androl., 36, 1996, No 1, [ 12 ] Thomas J., S. Fishel. J. Hall. Hum. Reprod., 12, 1997, No 1, [ 13 ] Sapundjiev E. Practicum of Cytology and Histology. Sofia, GERA-ART, [ 14 ] Johannisson E., R. Eliasson. Int. J. Androl., 7, 1978, [ 15 ] Sousa M., A. Barros, K. Takahaski. Hum. Reprod., 14, 1999, No 5, [ 16 ] Uchechukwu I., O. Ezeh. Human Reproduction, 15, 2000, No 11, [ 17 ] Dym M., D. Fawcett. Biol. Reprod., 4, 1971, [ 18 ] Atanassova N., L. Kancheva. Compt. rend. Acad. bulg. Sci., 49, 1996, No 6, Department of Experimental Morphology Institute of Experimental Morphology, Pathology and Anthropology with Museum Bulgarian Academy of Sciences Acad. G. Bonchev Str., Bl Sofia, Bulgaria stefi13831@ .bg 1296 S. Ivanova, P. Tzvetkova
SPERM MOTILITY AND FERTILIZING ABILITY OF MEN WITH INFERTILITY
SPERM MOTILITY AND FERTILIZING ABILITY OF MEN WITH INFERTILITY I. Ilieva, S. Ivanova, P. Tzvetkova and Y. Gluhcheva Institute of Experimental Morphology and Anthropology with Museum,Bulgarian Academy of
More informationRound Immature Spermatogenic Cells in Semen Fluids of Infertile Men with Diagnosis Migrating Testis. Two Casuistic Cases in Adults
Institute of Experimental Morphology, Pathology and Anthropology with Museum Bulgarian Anatomical Society Acta morphologica et anthropologica, 22 Sofia 2015 Round Immature Spermatogenic Cells in Semen
More informationTesticular fine needle aspiration as a diagnostic tool in nonobstructive
Asian J Androl 2005; 7 (3): 289 294 DOI: 10.1111/j.1745-7262.2005.00043.x. Original Article. Testicular fine needle aspiration as a diagnostic tool in nonobstructive azoospermia A. Bettella 1, A. Ferlin
More informationSemen Quality in Infertile Men with a History of Unilateral Cryptorchidism
Journal of Reproduction & Contraception (2004) 15 (3):139-143 Semen Quality in Infertile Men with a History of Unilateral Cryptorchidism P. Tzvetkova 1, Wei-Jie ZHU 2, D. Tzvetkov 3 1. Department of Immunoneuroendocrinology,
More informationMALE INFERTILITY & SEMEN ANALYSIS
MALE INFERTILITY & SEMEN ANALYSIS DISCLOSURE Relevant relationships with commercial entities none Potential for conflicts of interest within this presentation none Steps taken to review and mitigate potential
More informationThe Use of Rabbits in Male Reproductive Toxicology
Environmental Health Perspectives Vol. 77, pp. 5-9, 1988 The Use of Rabbits in Male Reproductive Toxicology by Daniel Morton* The rabbit is the smallest and least expensive laboratory animal in which serial
More informationPostgraduate Training in Reproductive Health
SURGICAL TREATMENT OF MALE INFERTILITY Georges A. de Boccard, M.D. Consultant Urologist F.M.H., F.E.B.U. Postgraduate Training in Reproductive Health Geneva Foundation for Medical Education and Research
More informationCytological findings of testicular fine needle aspiration in a sample of azoospermic Iraqi patients
Cytological findings of testicular fine needle aspiration in a sample of azoospermic Iraqi patients Basim Sh. Ahmed F.I.C.M.S Department of Pathology, College of Medicine, Al-Mustansiriya University, Baghdad,
More informationOutcome of repeated micro-surgical testicular sperm extraction in patients with non-obstructive azoospermia
Repeated micro-surgical testicular sperm extraction DOI: 10.1111/j.1745-7262.2007.00273.x www.asiaandro.com. Original Article. Outcome of repeated micro-surgical testicular sperm extraction in patients
More informationClinical characteristics of men with non-mosaic Klinefelter syndrome in northeastern China: implications for genetic counseling
Clinical characteristics of men with non-mosaic Klinefelter syndrome in northeastern China: implications for genetic counseling M. Zhang, H.-T. Fan, H.-S. Zheng, Q.-S. Zhang, S.-Q. Feng and R.-W. Li Andrology
More informationMale History, Clinical Examination and Testing
Male History, Clinical Examination and Testing Dirk Vanderschueren, MD, PhD Case Jan is 29 years old and consults for 1 year primary subfertility partner 28 years old and normal gynaecological investigation
More informationMale factors determining the outcome of intracytoplasmic sperm injection with epididymal and testicular spermatozoa
andrologia 35, 220 226 (2003) Accepted: April 25, 2003 Male factors determining the outcome of intracytoplasmic sperm injection with epididymal and testicular spermatozoa J. U. Schwarzer, K. Fiedler, I.
More informationImportance of Papanicolaou Staining for Sperm Morphologic Analysis Comparison With an Automated Sperm Quality Analyzer
Anatomic Pathology / Pap Staining for Sperm Morphologic Analysis Importance of Papanicolaou Staining for Sperm Morphologic Analysis Comparison With an Automated Sperm Quality Analyzer Smita Singh, MD,
More informationIN THE STUDY of male fertility and infertility there are several criteria which
Cytologic Examination of Semen Irwin N. Frank, A.B., John A. Benjamin, M.D., and James E. Segerson, M.D. IN THE STUDY of male fertility and infertility there are several criteria which have been established
More informationTESE: Testis Sperm Extraction
TESE: Testis Sperm Extraction Robert D. Oates, M.D., F.A.C.S. Department of Urology Boston University School of Medicine When is Microsurgical TESE indicated? Cases of Non-obstructive Azoospermia (NOA)
More informationSperm retrieval from patients with nonmosaic Klinefelter s syndrome by semen cytology examination
Sperm retrieval from patients with nonmosaic Klinefelter s syndrome by semen cytology examination Y.-T. Jiang 1, Y. Dong 1, X.-W. Yu 1, R.-C. Du 1,2, L.-L. Li 1,2, H.-G. Zhang 1 and R.-Z. Liu 1 1 Center
More informationWith advances in assisted reproduction techniques,
Journal of Andrology, Vol. 26, No. 6, November/December 2005 Copyright American Society of Andrology Clomiphene Administration for Cases of Nonobstructive Azoospermia: A Multicenter Study ALAYMAN HUSSEIN,*
More informationImmune response in obstructive male infertility. Prof. A.K.Sarda Department of Surgery Maulana Azad Medical College New Delhi
Immune response in obstructive male infertility Prof. A.K.Sarda Department of Surgery Maulana Azad Medical College New Delhi Sperm transport from the testicle Seminiferous tubule contractions of the myoid
More information* K.O. Ibadin, ** O. I. Enabulele, ** N. O. Eghafona, *** A. P. Osemwenkha
SEROEVIDENCE OF CHLAMYDIA TRACHOMATIS INFECTION IN INFERTILE MALE AND ITS ASSOCIATION WITH SEMEN QUALITY IN UNIVERSITY OF BENIN TEACHING HOSPITAL, BENIN CITY, NIGERIA * K.O. Ibadin, ** O. I. Enabulele,
More informationEffects of Cryopreservation on the Ultrastructure of Human Testicular Sperm
Journal of Reproduction & Contraception (2005) 16 (4):195-200 ORIGINAL PAPER Effects of Cryopreservation on the Ultrastructure of Human Testicular Sperm Xin-qiang LAI 1, Wei-jie ZHU 2, Jing LI 3, Fu-xing
More informationThe new 5 th WHO manual semen parameter reference values do they help or hinder?
The new 5 th WHO manual semen parameter reference values do they help or hinder? Roelof Menkveld, PhD Andrology Laboratory, Department of Obstetrics and Gynaecology, Tygerberg Academic Hospital and University
More informationMale Factor Infertility
Male Factor Infertility Simplified Evaluaon and Treatment* ^ * In 20 minutes or less In 20 slides ^ 5 minute office visit ALWAYS EVALUATE THE MALE & THE FEMALE Why 1. To help the coupleachieve a pregnancy
More informationTreatment of male idiopathic infertility with recombinant human follicle-stimulating hormone: a prospective, controlled, randomized clinical study
Treatment of male idiopathic infertility with recombinant human follicle-stimulating hormone: a prospective, controlled, randomized clinical study Carlo Foresta, M.D., Ph.D., a Andrea Bettella, M.D., Ph.D.,
More informationInfertility Sensitivity and Specificity of Ultrasonography in Predicting Etiology of Azoospermia
Infertility Sensitivity and Specificity of Ultrasonography in Predicting Etiology of Saad R. Abdulwahed, Essam-Eldeen M. Mohamed, Emad A. Taha, Medhat A. Saleh, Yaser M. Abdelsalam, and Ehab O. ElGanainy
More information15% ART accounts for ~4% of Australian births
The General Practice Education Day HealthEd / Generation Next 20 th February Sydney Declarations Male Infertility & Assisted Reproduction Prof Robert I McLachlan FRACP, Ph.D. Consultant Andrologist, Monash
More informationDEFINITION HX & PH/EX
DEFINITION HX & PH/EX Because of the success of the assisted reproductive techniques (ART), the evaluation of the man is often ignored. The physician should not forget the fact that many causes of male
More informationSeminal fluid analysis
What is semen? Semen is the fluid formed at ejaculation. Made of secretions of all the accessory glands of the male genital tract and testicular sperm component Semen quality is maintained by all the accessory
More informationUse of Testicular Sperm for ICSI in Non-Azoospermic Men: How Far Should we Go?
Use of Testicular Sperm for ICSI in Non-Azoospermic Men: How Far Should we Go? Armand Zini, MD, FRCSC McGill University Disclosure: Shareholder in YAD Tech Neutraceuticals Co. Sperm Retrieval: Overview
More informationDeterioration Of Sperm Morphology In Men Exposed To High Temperature
107 J Anat. Soc. India 50(2) 107-111 (2001) Deterioration Of Sperm Morphology In Men Exposed To High Temperature Dada, R.; *Gupta, N.P., Kucheria, K. Department of Anatomy & *Urology, All India Institute
More informationAbnormalities of Spermatogenesis
Abnormalities of Spermatogenesis Male Factor 40% of the cause for infertility Sperm is constantly produced by the germinal epithelium of the testicle Sperm generation time 73 days Sperm production is thermoregulated
More informationThe spermatogenesis CHARACTERISTICS OF THE SPERMATOZOON 26/04/2017. Reproductive Biotechnologies Andrology I. Prof. Alberto Contri
Reproductive Biotechnologies Andrology I The spermatogenesis Prof. Alberto Contri CHARACTERISTICS OF THE SPERMATOZOON 1) Aploid cell with high condensed DNA 2) Forward motility - flagellum 3) Enzymes for
More informationInhibin B plasma concentrations in oligozoospermic subjects before and after therapy with follicle stimulating hormone
Human Reproduction vol.14 no.4 pp.906 912, 1999 Inhibin B plasma concentrations in oligozoospermic subjects before and after therapy with follicle stimulating hormone Carlo Foresta 1,4, Andrea Bettella
More informationEFFECTS OF CoCl 2 AND Co-EDTA ON TESTICULAR MORPHOLOGY AND SPERM COUNT IN MOUSE
EFFECTS OF CoCl 2 AND Co-EDTA ON TESTICULAR MORPHOLOGY AND SPERM COUNT IN MOUSE Ekaterina Pavlova [a], Maria Madzharova [a], Donika Dimova [a],yordanka Gluhcheva [a], Juliana Ivanova [b], and Nina Atanassova
More informationEffect of cigarette smoking on morphological characteristics of sperm
Original article: Effect of cigarette smoking on morphological characteristics of sperm Dr. Mahadeo Maroti Zalke 1, Dr. Noorin Bhimani 2, Dr. Pushpa Pazare 3 1, 2 Assistant Professor, Dept. of Physiology,
More informationGUIDELINES ON THE INVESTIGATION AND TREATMENT OF MALE INFERTILITY
GUIDELINES ON THE INVESTIGATION AND TREATMENT OF MALE INFERTILITY G. Dohle (chairman), A. Jungwirth and W. Weidner. Eur Urol 2002;42(4):313-322 Eur Urol 2004;46(5):555-558 1. Introduction Infertility is
More information15% ART accounts for ~4% of Australian births
The General Practice Education Day HealthEd / Generation Next 5 th March Melbourne Declarations Male Infertility & Assisted Reproduction Prof Robert I McLachlan FRACP, Ph.D. Consultant Andrologist, Monash
More informationWhat You Need to Know
UW MEDICINE PATIENT EDUCATION What You Need to Know Facts about male infertility This handout explains what causes male infertility, how it is diagnosed, and possible treatments. Infertility is defined
More informationMale reproduction. Cross section of Human Testis ผศ.ดร.พญ.ส ว ฒณ ค ปต ว ฒ ภาคว ชาสร รว ทยา คณะแพทยศาสตร ศ ร ราชพยาบาล 1. Aims
Aims Male reproduction Male reproductive structure Spermatogenesis ส ว ฒณ ค ปต ว ฒ ห อง 216 โทร: 7578 Hypothalamo-pituitary-testicular axis Male sex hormone action Male reproductive structure Male reproductive
More informationGUIDELINES FOR THE INVESTIGATION AND TREATMENT OF MALE INFERTILITY
GUIDELINES FOR THE INVESTIGATION AND TREATMENT OF MALE INFERTILITY G.R. Dohle, Z. Kopa, A. Jungwirth, T.B. Hargreave. Eur Urol 2002;42(4):313-322 Eur Urol 2004;46(5):555-558 Definition Infertility is the
More informationSpermatogonial proliferation and apoptosis in hypospermatogenesis associated with nonobstructive azoospermia
FERTILITY AND STERILITY VOL. 76, NO. 5, NOVEMBER 2001 Copyright 2001 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Spermatogonial proliferation
More informationMale Reproductive System
Male Reproductive System organs that function in: gamete and hormone production not all in abdominal cavity paired testicles = controlled by LH & FSH duct systems accessory glands Testis: Gross Histology
More informationInduction of spermatogenesis in azoospermic men after varicocelectomy repair: an update
Induction of spermatogenesis in azoospermic men after varicocelectomy repair: an update Fábio Firmbach Pasqualotto, M.D., Ph.D., Bernardo Passos Sobreiro, M.D., Jorge Hallak, M.D., Ph.D., Eleonora Bedin
More informationSpermatogenesis in Man
Spermatogenesis in Man I. Nuclear Morphology During Spermatogenesis in Man BRUNETTO CHIARELLI, PH.D., ARTHUR FALEK, PH.D., KAREN J. BACK, B.S., and C. THOMAS COWART, M.D. THE SEQUENCE of transformations
More informationFunctional and cytologic features of the contralateral testis in cryptorchidism
FERTILITY AND STERILITY@ Copyright Ci') 1996 American Society for Reproductive Medicine Printed on acid-free paper in U. S. A. Functional and cytologic features of the contralateral testis in cryptorchidism
More informationComparative studies of spermatogenesis in fertile and
J Clin Pathol 1981 ;34:145-150 Comparative studies of spermatogenesis in fertile and subfertile men MA LAMONT,* MJW FAED,* AND K BAXBYt From the *Cytogenetics Laboratory, Ninewells Hospital and Medical
More informationChapter1 Introduction
Chapter1 Introduction Male subfertility is a very significant global problem. Epidemiological data show that approximately 1-in-7 couples are classed as subfertile [1]. Sperm dysfunction is the single
More informationENDOCRINE MANAGEMENT OF MALE INFERTILITY Francesco Lombardo
ENDOCRINE MANAGEMENT OF MALE INFERTILITY Francesco Lombardo Evidence-based medicine and male infertility therapy Control Randomization Placebo, cross over, double blind Inclusion and exclusion criteria
More informationTo General Embryology Dr: Azza Zaki
Introduction To General Embryology The Human Development is a continuous process that begins when an ovum from a female is fertilized by a sperm from a male. Cell division, growth and differentiation transform
More informationClinical evaluation of infertility
Clinical evaluation of infertility DR. FARIBA KHANIPOUYANI OBSTETRICIAN & GYNECOLOGIST PRENATOLOGIST Definition: inability to achieve conception despite one year of frequent unprotected intercourse. Male
More informationPhysiologic Anatomy of the Male Sexual Organs
Reproductive and Hormonal Functions of the Male The reproductive functions of the male can be divided into three major subdivisions: (1) spermatogenesis, which means simply the formation of sperm; (2)
More informationSTUDY OF SPERMATOZOA AND THEIR RELATIONSHIP WITH FERTILITY IN MEN OF ARUNACHAL PRADESH
Indian J Physiol Pharmacal 2002; 46 (1) : 92-96 STUDY OF SPERMATOZOA AND THEIR RELATIONSHIP WITH FERTILITY IN MEN OF ARUNACHAL PRADESH B. K. NATH* AND C. K. SINGH** *Department of Zoology, J N. College,
More information15% ART accounts for ~4% of Australian births
The General Practice Education Day HealthEd / Generation Next 23 rd July Brisbane Declarations Male Infertility & Assisted Reproduction Equity interest in Monash IVF Group Prof Robert I McLachlan FRACP,
More informationEmbryology 3. Spermatogenesis:
Embryology 3 Spermatogenesis: The 2 testis in males are each divided into lobes and lobules by connective tissue septa forming 250 lobule and in each lobule there are 1 to 4 seminefrous tubule ( so almost
More informationAl-Anbar Medical Journal
Clinical Patterns and Major Causes of Male Infertility In Fallujah City Ziad H. Abd FIBMS(Urology) College of Medicine, University of Anbar Qais Abdul-Rahman Thamer FIBMS(Urology) College of Medicine,
More informationRole Of Serum Hormone Indices Including Inhibin B And Scrotal Ultrasound In Evaluation Of Non Obstructive Male Factor Infertility
Article ID: WMC001510 ISSN 2046-1690 Role Of Serum Hormone Indices Including Inhibin B And Scrotal Ultrasound In Evaluation Of Non Obstructive Male Factor Infertility Author(s):Dr. Geetika, Dr. Sunita
More informationTesticular Toxicity: Evaluation During Drug Development Guidance for Industry
Testicular Toxicity: Evaluation During Drug Development Guidance for Industry DRAFT GUIDANCE This guidance document is being distributed for comment purposes only. Comments and suggestions regarding this
More informationCUA Guideline: The workup of azoospermic males
CUA GUIDELINE CUA Guideline: The workup of azoospermic males Keith Jarvi, MD, FRCSC; Kirk Lo, MD, FRCSC; Anthony Fischer, MD, FRCSC; John Grantmyre, MD, FRCSC; Armand Zini, MD, FRCSC; Victor Chow, MD,
More informationENZYMES IN THE SEMINAL PLASMA FROM AZOOSPERMIC MEN: CORRELATION WITH THE ORIGIN OF THEIR AZOOSPERMIA
FERTILITY AND STERILITY Copyright C'1981 The American Fertility Society Vol. 36, No.3, September 1981 PrinU!d in UBA. ENZYMES IN THE SEMINAL PLASMA FROM AZOOSPERMIC MEN: CORRELATION WITH THE ORIGIN OF
More informationMale Reproductive System
Male Reproductive System Constitution of male reproductive system Genital gland ----testis Genital ducts epididymis / ductus deferens / urinary duct Accessory sex glands Penis prostate gland Seminal vesicle
More informationMale Factor Infertility and Health. Karen Baker, MD Associate Professor Duke University, Division of Urology
Male Factor Infertility and Health Karen Baker, MD Associate Professor Duke University, Division of Urology Fertility and Cancer Heart disease Metabolic syndrome Diabetes Early death Goals: Review literature
More informationPrediction of Successful Sperm Retrieval in Patients with Nonobstructive Azoospermia
Urology Journal UNRC/IUA Vol. 3, No. 2, 92-96 Spring 2006 Printed in IRAN Prediction of Successful Sperm Retrieval in Patients with Nonobstructive Azoospermia Seyed Amirmohsen Ziaee, 1 * Mohammadreza Ezzatnegad,
More informationEvaluation of hormonal and physical factors responsible for male infertility in Sagamu South Western Nigeria
Available online at wwwscholarsresearchlibrarycom Scholars Research Library Der Pharmacia Lettre, 2012, 4 (5):1475-1479 (http://scholarsresearchlibrarycom/archivehtml) ISSN 0975-5071 USA CODEN: DPLEB4
More informationNovel Technologies for Selecting the Best Sperm for IVF and ICSI
Novel Technologies for Selecting the Best Sperm for IVF and ICSI Denny Sakkas, Ph.D. Scientific Director, Boston IVF Waltham, MA, USA Testing The Sperm Population NOW Sperm DNA testing Although we are
More informationLindsay Machan, MD University of British Columbia Vancouver, British Columbia
Varicocele Embolization and Serum Testosterone: What is the Evidence? Lindsay Machan, MD University of British Columbia Vancouver, British Columbia Lindsay Machan, MD, FSIR Stock: A4L, Calgary Scientific,
More informationDISORDERS OF MALE GENITALS
Wit JM, Ranke MB, Kelnar CJH (eds): ESPE classification of paediatric endocrine diagnosis. 9. Testicular disorders/disorders of male genitals. Horm Res 2007;68(suppl 2):63 66 ESPE Code Diagnosis OMIM ICD10
More informationCell Divisions. The autosomes represent the whole body. * Male Sex Chromosomes: XY * Female Sex Chromosomes: XX
Cell Divisions Each Cell (including gonads) has 46 chromosomes (23 pairs of chromosomes: 22 pairs of autosomes, 1 pair of sex chromosomes) which are located in the nucleus). The autosomes represent the
More information- test also turn out normal_ A biopsy from the testicle, even of young men, usually shows a more or less pronounced
VOLUME 20, No. 3 SEPT 1979 (SUPPLEMENT 1) THE EFFECT OF TRENTAL ON SPERMIOGRAFIC PARAMETERS, A CLINICAL STUDY IN PATIENTS WITH REDUCED FERTILITY Prof. Dr. med. Hans -J. Heite, Freiburg (former Medical
More informationMolecular screening for Yq microdeletion in men with idiopathic oligozoospermia and azoospermia
Molecular screening for Yq microdeletion in men with idiopathic oligozoospermia and azoospermia RIMA DADA, N P GUPTA* and K KUCHERIA Department of Anatomy and *Department of Urology, All India Institute
More informationMale Reproduction Organs. 1. Testes 2. Epididymis 3. Vas deferens 4. Urethra 5. Penis 6. Prostate 7. Seminal vesicles 8. Bulbourethral glands
Outline Terminology Human Reproduction Biol 105 Lecture Packet 21 Chapter 17 I. Male Reproduction A. Reproductive organs B. Sperm development II. Female Reproduction A. Reproductive organs B. Egg development
More informationGenetics Aspects of Male infertility
Genetics Aspects of Male infertility A. Ebrahimi, Molecular Genetic SM Kalantar, Prof. Molecular Cytogenetic Research & Clinical Centre for Infertility, Reproductive & Genetic Unit, Yazd Medical Sciences
More informationdescribe the parts and function of semen and the glands that contribute to it
You need to be able to: describe spermatogenesis (How is sperm made?) describe the anatomy of a sperm describe the parts and function of semen and the glands that contribute to it How is sperm made? Spermatogenesis
More informationHistology of Male Reproductive system (1)
Histology of Male Reproductive system (1) Prof. Dr. Malak A. Al-yawer Learning Objectives At the end of this lecture, the medical student will be able to: State the organization of the testis Define seminiferous
More informationProceedings of the Society for Theriogenology 2012 Annual Conference
www.ivis.org Proceedings of the Society for Theriogenology 2012 Annual Conference Aug. 20-25, 2012 Baltimore, MD, USA www.therio.org/ Next Meeting: Aug. 7-10, 2013 Louisville, KY, USA Reprinted in the
More informationReproductive Effects of Feeding Gossypol and Vitamin E to Bulls
Reproductive Effects of Feeding Gossypol and Vitamin E to Bulls J. Velasquez-Pereira P.J. Chenoweth L.R. McDowell C.A. Risco C.A. Staples D. Prichard F.G. Martin M.C. Calhoun S.N. Williams N.S. Wilkinson
More informationCM-B 2008: Semen Analysis INTRODUCTION ANATOMY AND PHYSIOLOGY
INTRODUCTION Semen analysis is a laboratory test that is primarily used for evaluating fertility potential and for assessing success following a vasectomy procedure. The composition of semen, also known
More informationACUPUNCTURE AND MALE INFERTILITY
ACUPUNCTURE AND MALE INFERTILITY About male infertility The clinical definition of male infertility is the presence of abnormal semen parameters in the male partner of a couple who have been unable to
More informationA comparison between open and percutaneous needle biopsies in men with azoospermia
Human Reproduction vol.13 no.5 pp.1266 1271, 1998 A comparison between open and percutaneous needle biopsies in men with azoospermia B.Rosenlund 1,6, U.Kvist 3, L.Plöen 4, B.Lundh Rozell 2, P.Sjöblom 1
More informationMale factors can be identified as the cause of infertility in 30~40% of couples and a
Focused Issue of This Month Causes and Diagnosis of Male Infertility Nam Cheol Park, MD Department of Urology, Pusan National University College of Medicine Email : pnc@pusan.ac.kr J Korean Med Assoc 2007;
More informationMultiple testicular sampling in non-obstructive azoospermia is it necessary?
Human Reproduction vol.13 no.11 pp.3081 3085, 1998 Multiple testicular sampling in non-obstructive azoospermia is it necessary? R.Hauser 1,3, A.Botchan 1, A.Amit 2, D.Ben Yosef 2, R.Gamzu 1, G.Paz 1, J.B.Lessing
More informationReproductive System Purpose General Structures Male Structures Functions Female Anatomy Structures Functions Clinical Applications
The Reproductive System: Male, Ch 23 Outline of class lecture After studying the male reproductive system you should be able to: 1. Define the purpose of reproduction and identify the general organs of
More informationWhat should the clinician ask and look for in the initial consultation?
What should the clinician ask and look for in the initial consultation? ESHRE Campus Course, Thessaloniki, Greece, 1-3 October 2009 Reproductive andrology: linking laboratory to clinical practice Tim Hargreave
More informationACUPUNCTURE AND MALE INFERTILITY
ACUPUNCTURE AND MALE INFERTILITY About male infertility The clinical definition of male infertility is the presence of abnormal semen parameters in the male partner of a couple who have been unable to
More informationInfertility is not an uncommon problem in Western
Review Article A Practical Approach to Testicular Biopsy Interpretation for Male Infertility Lisa A. Cerilli, MD; Wayne Kuang, MD; David Rogers, MD Infertility is not an uncommon problem in Western societies
More informationSurgical Sperm Retrieval
Saint Mary s Hospital Department of Reproductive Medicine Information for Patients Surgical Sperm Retrieval About one man in a hundred produces no sperm (10-15% of all sub fertile men) - a condition known
More informationEVALUATION OF MALE AND FEMALE INFERTILITY ANDREA BARRUECO AMERICAN CENTER FOR REPRODUCTIVE MEDICINE CLEVELAND CLINIC ART TRAINING 2018
EVALUATION OF MALE AND FEMALE INFERTILITY ANDREA BARRUECO AMERICAN CENTER FOR REPRODUCTIVE MEDICINE CLEVELAND CLINIC ART TRAINING 2018 The evaluation of an infertile couple requires an understanding of
More informationPatterns of Testicular Histopathology in Egyptian Azoospermic Men
ISPUB.COM The Internet Journal of Urology Volume 13 Number 1 Patterns of Testicular Histopathology in Egyptian Azoospermic Men M K Khalifa, A M Issa, M O El Hamshary, K Z Shaeer Citation M K Khalifa, A
More informationMale reproductive physiology
START Lecture Series Crown Conference Centre, Melbourne Feb 18 th 2017 Male reproductive physiology Prof Robert I McLachlan FRACP, Ph.D., AM Director, Clinical Research, Hudson Institute Consultant Andrologist,
More informationImpact of clinical varicocele and testis size on seminal reactive oxygen species levels in a fertile population: a prospective controlled study
MALE FACTOR Impact of clinical varicocele and testis size on seminal reactive oxygen species levels in a fertile population: a prospective controlled study Marcello Cocuzza, M.D., a,b Kelly S. Athayde,
More informationEvaluation of the Association of the Presence of Subclinical Varicocele with Subfertility in Men
Evaluation of the Association of the Presence of Subclinical Varicocele with Subfertility in Men Original Article Ahmed M Hassanin, Hamed Abdalla Hamed, Maha Abdallah Arafat Department of Andrology and
More informationII.3.9 Evaluation of Testicular Biopsy Samples from the Clinical Perspective
454 Diagnostic Tools.9 Evaluation of Testicular Biopsy Samples from the Clinical Perspective M. Bergmann Summary Testicular biopsy is indicated therapeutically in cases of obstructive azoospermia, and
More informationTestosterone Therapy-Male Infertility
Testosterone Therapy-Male Infertility Testosterone Therapy-Male Infertility Many men are prescribed testosterone for a variety of reasons. Low testosterone levels (Low T) with no symptoms, general symptoms
More informationVariability in testis biopsy interpretation: implications for male infertility care in the era of intracytoplasmic sperm injection
Variability in testis biopsy interpretation: implications for male infertility care in the era of intracytoplasmic sperm injection Matthew R. Cooperberg, M.D., a Thomas Chi, B.A., a Amir Jad, M.D., a Imok
More informationHISTOLOGIC CHANGES IN THE SEMINIFEROUS TUBULES AFTER VASECTOMY
FERTILItY AND STI!RILITY Copyright 1974 The American Fertility Society Vol. 25, No.8, August 1974 PTillted in U.S.AI HISTOLOGIC CHANGES IN THE SEMINIFEROUS TUBULES AFTER VASECTOMY FLETCHER C. DERRICK,
More informationRole of Local Immune Reaction in Primary Obstructive Male Infertility
AJMS Al Ameen J Med Sci (20 1 2 )5 (1 ):5 3-6 2 (A US National Library of Medicine enlisted journal) I S S N 0 9 7 4-1 1 4 3 C O D E N : A A J M B G ORIGI NAL ARTICLE Role of Local Immune Reaction in Primary
More informationJournal of Paramedical Sciences (JPS) Spring 2011 Vol.2, No.2 ISSN
Rare association of multiple etiologies in a severe oligoasthenospermic male Vineeth V.S. 1, Mohsen Najafi 1, Sreenivasa G. 1, Sharath Kumar C. 2, Suttur S. Malini 1,* 1 Department of Studies in Zoology,
More informationMALE REPRODUCTIVE SYSTEM
MALE REPRODUCTIVE SYSTEM The male reproductive system consists of primary sex organs (testes) and secondary or accessory sex organs. The secondary organs consist of a series of genital ducts (ductules
More informationU.I.O.Ezeh 1, H.D.M.Moore 1,2,3 and I.D.Cooke 1
Human Reproduction vol.13 no.11 pp.3066 3074, 1998 Correlation of testicular sperm extraction with morphological, biophysical and endocrine profiles in men with azoospermia due to primary gonadal failure
More informationChapter 7. Male Reproductive System
Chapter 7 Male Reproductive System 1 Sexual Reproduction Sexual reproduction two individuals produce offspring that have genetic characteristics from both parents Sexual reproduction introduces new gene
More informationBank your future: Insemination and semen cryopreservation. Disclosure. Lecture objectives
Bank your future: Insemination and semen cryopreservation Roelof Menkveld, PhD Andrology Laboratory, Department of Obstetrics and Gynaecology, Tygerberg Academic Hospital and University of Stellenbosch.
More informationInduction of spermatogenesis in azoospermic men after varicocele repair
Human Reproduction Vol.18, No.1 pp. 108±112, 2003 DOI: 10.1093/humrep/deg032 Induction of spermatogenesis in azoospermic men after varicocele repair FaÂbio F.Pasqualotto 1, AntoÃnio M.Lucon, Jorge Hallak,
More information