X/99/$03.00/0 Vol. 84, No. 5 The Journal of Clinical Endocrinology & Metabolism Copyright 1999 by The Endocrine Society
|
|
- Hester Willis
- 6 years ago
- Views:
Transcription
1 X/99/$03.00/0 Vol. 84, No. 5 The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright 1999 by The Endocrine Society A New Contributing Factor to Polycystic Ovary Syndrome: The Genetic Variant of Luteinizing Hormone* JUHA S. TAPANAINEN, RIITTA KOIVUNEN, BART C. J. M. FAUSER, ANN E. TAYLOR, RICHARD N. CLAYTON, MADHURIMA RAJKOWA, DAVINIA WHITE, STEPHEN FRANKS, LEENA ANTTILA, KIM S. I. PETTERSSON, AND ILPO T. HUHTANIEMI Department of Obstetrics and Gynecology, University of Oulu (J.S.T., R.K.), Oulu, Finland; the Department of Obstetrics and Gynecology, Dijkzigt Academic Hospital and Erasmus University (B.C.J.M.F.), 3015 GD Rotterdam, The Netherlands; Reproductive Endocrine Unit, Massachusetts General Hospital (A.E.T.), Boston, Massachusetts 02114; the Department of Medicine, School of Postgraduate Medicine, Keele University (R.N.C., M.R.), Hartshill, Stoke-on-Trent, United Kingdom ST4 6QG; the Department of Reproductive Science and Medicine, Imperial College School of Medicine, St. Mary s Hospital (D.W., S.F.), London, United Kingdom; and the Departments of Obstetrics and Gynecology (L.A.), Biotechnology (K.S.I.P.), and Physiology (I.T.H.), University of Turku, Turku, Finland ABSTRACT Although the etiology of polycystic ovary syndrome (PCOS) is still unclear, LH is considered to play a central role in its pathogenesis. An immunologically anomalous form of LH, with two point mutations in the LH gene, has been recently described. This genetic variant of LH (v-lh), of wide geographic distribution, is functionally different from wild-type (wt) LH. To assess the role of the v-lh in PCOS, we analyzed its frequency in groups of PCOS patients from Finland, The Netherlands, the United Kingdom, and the United States. The LH status was determined by two immunofluorometric assays from a total of 1466 subjects. The carrier frequency of the v-lh allele in the whole study population was 18.5%, being highest (28.9%) in Finland and lowest (11.2%) in The Netherlands. In the individual countries, the frequency of v-lh was similar in obese and nonobese controls, but in The Netherlands and Finland, it was 5- to 7-fold lower in obese PCOS subjects compared with that in the other groups (2 4.5% vs. Received August 26, Revision received October 28, Accepted January 22, Address all correspondence and requests for reprints to: Dr. Juha S. Tapanainen, Department of Obstetrics and Gynecology, Oulu University Hospital, FIN Oulu, Finland. juha.tapanainen@ oulu.fi. * This work was supported by grants from the Sigrid Jusélius Foundation and the Academy of Finland %; P 0.05). A similar tendency was found in the United States (5.7% vs %), but not in the United Kingdom. The overall high prevalence of v-lh in healthy women and women with PCOS suggests that it is compatible with fertility. The similar frequency of v-lh in healthy nonobese and obese women indicates that obesity per se is not related to the variant. In contrast, the lower frequency of v-lh in obese PCOS patients suggests that v-lh somehow protects obese women from developing symptomatic PCOS. However, the regional differences in this finding between patients with apparently similar diagnostic criteria emphasizes the multifactorial nature of this syndrome, and that its pathogenesis may vary according to the genetic background. Although the definitive role of v-lh in PCOS remains to be proven, its determination may improve the prediction of risk of PCOS, especially in obese women. (J Clin Endocrinol Metab 84: , 1999) POLYCYSTIC ovary syndrome (PCOS) is the most common ovarian disorder, with typical features of obesity, anovulation, hyperandogenism, hirsutism, and infertility. The prevalence of PCOS varies from 1 8% in the general population depending on the diagnostic criteria (1 3). It is characterized by increased levels of circulating LH, increased ovarian androgen production, hyperinsulinemia, and multiple cysts in the ovaries related to arrested follicular development. Despite extensive research, the etiology and basic mechanisms underlying PCOS are still largely unknown. New theories have been introduced, and the interest in the genetics of PCOS has increased considerably during recent years (4). We have previously discovered in Finland a genetic variant of LH (v-lh) that contains two missense point mutations in the LH gene (Trp 8 Arg and Ile 15 Thr) (5, 6). Subsequently, a similar LH form was described from Japan (7), and very recently it was reported to be a common polymorphism with world-wide distribution (8). The two mutations, rather than representing neutral polymorphisms, alter the biological function of LH. v-lh has elevated in vitro bioactivity compared to that of wild-type LH (wt-lh), but its half-time in the circulation is significantly shorter (9). Whether the opposite alterations in the in vitro and in vivo bioactivities of v-lh reflect higher or lower overall bioactivity still remains obscure. Nevertheless, the evidence is emerging that LH action in carriers of the v-lh allele differs from that in individuals with wt-lh. v-lh shows association with various clinical conditions, such as elevated serum estradiol, testosterone, and sex hormone-binding globulin in the follicular phase of the menstrual cycle (10); menstrual disorders (7, 11); PCOS (10); and slow pace of puberty (12). In addition, v-lh is widely distributed in different ethnic groups, varying in frequency from 0% in Kotas from South India to an extremely high 53.5% in aboriginal Australians (6). 1711
2 1712 TAPANAINEN ET AL. JCE&M 1999 Vol 84 No 5 As PCOS patients often have high LH levels, and altered LH action is involved in the pathogenesis of this disease (13, 14), we decided to study the prevalence and distribution of v-lh in a large population of women with PCOS. We studied retrospectively the prevalence of v-lh in nonobese and obese PCOS patients in three patient cohorts from Europe and one from the United States and compared the results with those in healthy control women from the same populations. Subjects and Methods Subjects A total of 1466 serum samples from women in Finland, The Netherlands, the United Kingdom, and the United States (Caucasians from Boston, MA) were analyzed for v-lh. For the comparison between healthy and PCOS subjects, 363 women fulfilled the criteria of PCOS, 79 women had polycystic ovaries without other symptoms of PCOS, and 944 healthy women of similar age with the PCOS subjects served as controls. The age of the subjects varied between yr. A body mass index (BMI; kilograms per meter squared) more than 27 was classified as obese and a BMI of 27 or less was classified as nonobese. The diagnostics of PCOS were polycystic ovaries by transvaginal ultrasound ( 8 follicles of 2 8 mm diameter in 1 plane section), oligoamenorrhea (intermenstrual interval, 35 days), and hirsutism (Ferriman-Gallwey score, 7), or raised serum testosterone ( 2.7 nmol/l). The relative percentages of obese control and PCOS subjects were different in the 4 countries (P ; Table 1); therefore, the data based on BMI were not combined. Hormone assay Two immunofluorometric assays (DELFIA, Wallac Oy, Turku, Finland) with different combinations of monoclonal antibodies (Mab) were used to determine the LH phenotypes. The reference method (assay 2) used two LH -specific Mab that recognize wt and v-lh with similar stoichiometries (8). The other assay (assay 1) uses Mab that recognize only the intact LH / -dimer and the -subunit, but not v-lh (5). The ratio of LH measured by assay 1/assay 2 allowed classification of the samples into three categories: 1) more than 0.9 (normal ratio), the subject has two normal LH alleles; 2) (low ratio), the subject is heterozygous for the mutant LH gene; and 3) less than 0.15 (zero ratio), the subject is homozygous for the mutant LH gene (9). The intra- and interassay variations of assays 1 and 2 were less than 4% and 5%, respectively, at LH concentrations at and above the lowest standard concentration of 0.6 IU/L of the WHO International Reference Preparation 80/552. The serum samples from cycling women were obtained in the follicular phase, and those from subjects with amenorrhea and oligomenorrhea were obtained randomly. Statistical analysis The frequencies of v-lh among the groups were compared using the 2 test. The confidence intervals for the differences of the frequencies of v-lh among the countries were calculated using the Goodman statistic (15). The serum LH concentrations were compared using one-way ANOVA or Student s t test. Results The carrier frequency of the v-lh allele in the whole study population was 18.5%; it was highest (28.9%) in Finland and lowest (11.2%) in The Netherlands (Table 2). In each country studied, the v-lh carrier frequency was similar in obese and nonobese controls, but it was significantly lower in obese PCOS subjects in The Netherlands and Finland, where the proportions of v-lh carriers in obese PCOS subjects were only 2.0% and 4.5%, respectively (Fig. 1). In contrast to these countries, no such difference, or even a tendency, was seen in United Kingdom. In the United States, such a tendency was apparent (Fig. 1). The number of women homozygous for v-lh was only 25 (1.7%), and none of them was obese. The frequencies of v-lh carriers in nonobese and obese women with PCO only from Finland and United Kingdom were 25.4% and 18.7%, respectively. However, the number of these subjects was only 16, which limits the value of the comparison. The PCOS patients had significantly higher serum levels of LH than control subjects [PCOS: 7.5 IU/L; 95% confidence interval (CI), ; controls: 4.4 IU/L; 95% CI, ; P 0.001] measured by assay 2. The subjects with normal and low ratios exhibited similar serum concentrations of LH, but the nonobese control women with zero ratio (homozygous for v-lh) had significantly lower levels of LH than those with wt-lh or low ratio (heterozygous for v-lh; Table 3). TABLE 1. The frequency of nonobese and obese control (A) and PCOS (B) women in different study groups in different countries Controls Controls 27 CI 95% 27 CI 95% A. Finland (n 299) 266 (88.9) (11.1) a Netherlands (n 204) 146 (71.6) (28.4) United Kingdom (n 233) 176 (75.5) (24.5) USA (n 208) 181 (87.0) (13.0) a PCOS PCOS 27 CI 95% 27 CI 95% B. Finland (n 61) 39 (63.9) (36.1) b,c Netherlands (n 117) 68 (58.1) (41.9) b United Kingdom (n 122) 50 (41.0) (59.0) USA (n 63) 28 (44.4) (55.6) The data are expressed as numbers of subjects, with the frequencies in parentheses (percentages). a P compared to Netherlands; P compared to United Kingdom. b P 0.01 compared to United Kingdom. c P 0.05 compared to USA.
3 LH AND THE ETIOLOGY OF PCOS 1713 TABLE 2. The carrier frequency of the wt and v-lh alleles in different countries, as determined by LH immunoassays Finland (n 425) Netherlands (n 347) United Kingdom (n 404) USA (n 290) Normal ratio 302 (71.1) 308 (88.8) 336 (83.2) 249 (85.9) Low ratio 111 (26.1) 38 (10.95) 66 (16.3) 31 (10.7) Zero ratio 12 (2.8) 1 (0.3) 2 (0.5) 10 (3.5) Low zero ratio 123 (28.9) 39 (11.2) 68 (16.8) 41 (14.1) CI CI a CI a CI a Allele frequency 135 (15.9) 40 (5.8) 70 (8.7) 51 (8.8) CI CI a CI a CI a The normal ratio individuals are homozygotes for wt-lh, those with low ratio are heterozygotes, and those with zero ratio are v-lh homozygotes. Percentages are given in parentheses. a P 0.05 compared to Finland. FIG. 1. The frequency (percentage) of v-lh (homozygotes and heterozygotes) in the different countries among controls and PCOS women with BMI of 27 or less or with BMI of more than 27 kg/m 2. The number of subjects is indicated inside the bars. The frequency of v-lh between controls and PCOS women was compared using 2 test: a, P 0.05; b, P 0.01; c, P 0.03; after continuity correction, P 0.07 compared to controls with BMI above 27 kg/m 2. Discussion The present study on women with PCOS confirms our previous findings on the common occurrence of the v-lh and its considerable variation among different populations and even within Caucasian populations. The overall high prevalence of v-lh suggests that it is compatible with fertility, and in some conditions it may even be beneficial. This could contribute to the wide variation in its frequency between different populations, i.e. from 0% to more than 50% (6, 8). With regard to PCOS, the most striking finding was the low v-lh frequency of 2 4.5% in obese patients from The Netherlands and Finland, with a similar tendency in the United States. The in vitro bioactivity of v-lh is higher than that of wt-lh, whereas its in vivo half-life is shorter than that of wt-lh (9, 11). It is therefore unclear whether its high activity at the receptor site but shorter half-time in the circulation result in a net increase or decrease in the overall bioactivity
4 1714 TAPANAINEN ET AL. JCE&M 1999 Vol 84 No 5 TABLE 3. Serum concentrations of LH in PCOS subjects and controls with wt-lh (normal assay 1/assay 2 ratio) or with v-lh (low or zero ratio) BMI Controls 27 PCOS 27 CI 95% Controls 27 PCOS 27 CI 95% wt-lh (IU/L) 4.2 (2.2) 8.1 (2.1) a 4.3, (1.9) 6.7 (2.3) 2.5, 1.5 (n 573) (n 139) P (n 139) (n 143) P 0.05 v-lh (IU/L) 4.5 (1.8) 8.6 (1.8) 4.8, (1.7) 7.4 (2.7) 4.3, 1.7 (n 140) (n 27) P (n 29) (n 19) P Low ratio only 4.6 (1.7) 8.2 (1.8) 4.5, (1.7) 7.4 (2.7) 4.3, 1.7 (n 127) (n 23) P (n 29) (n 19) P Zero ratio only 3.9 (1.4) b 10.6 (2.8) 8.5, 4.9 c c c (n 13) (n 4) P 0.05 Values are geometric means (SD). The 95% confidence intervals for the differences of the means between controls and PCOS subjects in the same weight group are calculated. Student s two-tailed t test was used for all paired comparisons, as all variables were normally distributed after log transformation. a P vs. PCOS with BMI greater than 27. b P 0.05 vs. respective wt-lh and heterozygote (low ratio only). c No zero ratio found in obese subjects. of in vivo. It is also possible that the nature of the wt- and v-lh peaks (long vs. short) in the face of unaltered pulse frequency (9) will cause qualitative changes in target cell responses to LH stimulation. The LH action in heterozygotes, with long and short acting hormones in each pulse, may be distinct from that of wt-lh or v-lh alone. In support of this, we have found a variety of differences in LH action between wt-lh and mainly heterozygous individuals, that cannot be easily explained by quantitative differences in LH action. Women heterozygous for v-lh have significantly elevated levels of serum estradiol, testosterone, and sex hormonebinding globulin in the follicular phase (10). Heterozygous boys have a slower progression of puberty (12). Japanese studies report menstrual disturbances in women homozygous for the v-lh allele (7, 11). As v-lh is apparently related to altered LH action, and LH is considered to play a central role in the pathogenesis of PCOS (13, 14), it is intriguing to interpret the present results. Obesity per se was not related to the variant heterozygosity, as the carrier frequency was the same in lean and obese control women. However, all of the homozygous women were nonobese, but their number was only 25. The low frequency of v-lh in obese PCOS patients in 3 of the populations studied suggests that obese women with v-lh may somehow be protected from developing symptomatic PCOS, and those with wt-lh are more likely to develop the disease. Previously, Rajkhowa et al. (11) from the United Kingdom have shown that obese women with PCOS exhibit a higher frequency of v-lh than obese controls. The present study confirmed this finding, which is at variance with the conspicuously low frequency of v-lh in obese PCOS subjects in Finland and The Netherlands, and with a similar trend in the United States. This discrepancy is difficult to explain, but given the multifactorial pathogenesis of PCOS, it is possible that another genetic factor(s), enriched in the United Kingdom population, alters the ovarian response to v-lh. Another discrepant finding was the overrepresentation of v-lh homozygotes in the United States population. As genetic isolation in this Caucasian population from the Boston area is unlikely, and all of the other populations studied to date for frequency of the v-lh allele are in Hardy-Weinberg equilibrium (6, 8), it apparently represents chance. The high overall frequency of the v-lh allele in women in general and its low frequency in obese PCOS patients suggest that v-lh has a role in reproductive functions and may somehow contribute to the pathogenesis of PCOS in obese individuals. Although it remains unknown whether the two mutations in v-lh lead to a net increase or decrease in the overall LH action, it is tempting to speculate that it offers advantage or disadvantage to certain individuals depending on their genetic background and environment. Hyperinsulinemia, hyperandrogenism, and dyslipidemia are commonly found in women with PCOS (16, 17). PCOS appears often at a young age, and therefore, we should be able to identify young women at future risk of these hormonal and metabolic changes. As a prognostic or diagnostic approach, the detection of v-lh may allow the discrimination between individuals with high and low risks of PCOS. Acknowledgments We thank Drs. Janet Hall, Kathryn Martin, William Crowley, Nanette Santoro, and Judith Adams for subject recruitment, and Sirkka Pramila, M.Sc., for statistical analysis. References 1. Franks S Polycystic ovary syndrome: a changing perspective. Clin Endocrinol (Oxf). 31: Futterweit W, Mechanick JI Polycystic ovarian disease: etiology, diagnosis, and treatment. Compr Ther. 14: Franks S Polycystic ovary syndrome. N Engl J Med. 333: Franks S, Gharani N, Waterworth D, et al The genetic basis of polycystic ovary syndrome. Hum Reprod. 12: Petterson K, Ding Y-Q, Huhtaniemi I An immunologically anomalous luteinizing hormone variant in a healthy woman. J Clin Endocrinol Metab. 74: Nilsson C, Jiang M, Pettersson K, et al A common genetic variant of the human luteinizing hormone (LH); determination by allele specific oligonucleotide hybridization assay and by variant specific immunoassay. Clin Endocrinol (Oxf). 49: Furui K, Suganuma N, Tsukahara S-I, et al Identification of two point mutations in the gene coding luteinizing hormone (LH) subunit, associated with immunologically anomalous LH variants. J Clin Endocrinol Metab. 78: Nilsson C, Pettersson K, Millar RP, Coerver KA, Matzuk MM, Huhtaniemi I Worldwide frequency of a common genetic variant of luteinizing hormone: an international collaborative research. Fertil Steril. 67: Haavisto A-M, Pettersson K, Bergendahl M, Virkamäki A, Huhtaniemi I.
5 LH AND THE ETIOLOGY OF PCOS Occurrence and biological properties of a common genetic variant of luteinizing hormone. J Clin Endocrinol Metab. 80: Rajkhowa M, Talbot JA, Jones PW, et al Prevalence of an immunological LH -subunit variant in a UK population healthy women and women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 43: Suganuma N, Furui K, Furuhashi M Screening of the mutations in luteinizing hormone -subunit in patients with menstrual disorders. Fertil Steril. 336: Raivio T, Huhtaniemi I, Anttila R, et al The role of luteinizing hormone gene polymorphism in the onset and progression of puberty in healthy boys. J Clin Endocrinol Metab. 81: Balen AH Hypersecretion of luteinizing hormone and the polycystic ovary syndrome. Hum Reprod. 8: Balen AH, Conway GS, Kaltsas G, et al Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod. 10: Miller R Multiple comparisons. In: Kotz S, Johnson NL, eds. Encyclopedia of statistical sciences. New York: Wiley and Sons; Conway GS, Agrawal R, Betteridge DJ, Jacobs HS Risk factors for coronary heart disease in lean and obese women with the polycystic ovary syndrome. Clin Endocrinol (Oxf). 37: Conway GS, Jacobs HS Clinical implications of hyperinsulinaemia in women. Clin Endocrinol (Oxf). 39:
The prevalence of polycystic ovaries in healthy women
Acta Obstet Gynecol Scand 1999; 78: 137 141 Copyright C Acta Obstet Gynecol Scand 1999 Printed in Denmark all rights reserved Acta Obstetricia et Gynecologica Scandinavica ISSN 0001-6349 ORIGINAL ARTICLE
More informationCHAPTER V. Luteinizing hormone beta (LHβ) gene SNPs and its. association with PCOS
CHAPTER V Luteinizing hormone beta (LHβ) gene SNPs and its association with PCOS 5.0. Introduction Luteinizing hormone (LH), a heterodimeric glycoprotein hormone secreted from anterior pituitary gonadotropes
More informationPOLYCYSTIC OVARY SYNDROME
FERTILITY AND STERILITY VOL. 71, NO. 3, MARCH 1999 Copyright 1999 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. POLYCYSTIC OVARY SYNDROME
More informationGenetic Variant of Luteinizing Hormone: Impact on Gonadal Steroid Sex Hormones in Women
Physiol. Res. 50: 583-587, 2001 Genetic Variant of Luteinizing Hormone: Impact on Gonadal Steroid Sex Hormones in Women M. HILL, I.T. HUHTANIEMI 1, R. HAMPL, L. STÁRKA Institute of Endocrinology, Prague,
More informationROLE OF HORMONAL ASSAY IN DIAGNOSING PCOD DR GAANA SREENIVAS (JSS,MYSURU)
ROLE OF HORMONAL ASSAY IN DIAGNOSING PCOD DR GAANA SREENIVAS (JSS,MYSURU) In 1935, Stein and Leventhal described 7 women with bilateral enlarged PCO, amenorrhea or irregular menses, infertility and masculinizing
More informationGonadotrophin treatment in patients with Polycystic Ovary Syndrome
Int. J. Adv. Res. Biol. Sci. (218). 5(4): 95-99 International Journal of Advanced Research in Biological Sciences ISSN: 2348-869 www.ijarbs.com DOI: 1.22192/ijarbs Coden: IJARQG(USA) Volume 5, Issue 4-218
More informationThe prevalence of polycystic ovary syndrome in Iranian women based on different diagnostic criteria
Prace oryginalne/original papers Endokrynologia Polska/Polish Journal of Endocrinology Tom/Volume 62; Numer/Number 3/2011 ISSN 0423 104X The prevalence of polycystic ovary syndrome in Iranian women based
More informationMETABOLIC RISK MARKERS IN WOMEN WITH POLYCYSTIC OVARIAN MORPHOLOGY
Vuk Vrhovac University Clinic Dugi dol 4a, HR-10000 Zagreb, Croatia Original Research Article Received: February 18, 2010 Accepted: March 3, 2010 METABOLIC RISK MARKERS IN WOMEN WITH POLYCYSTIC OVARIAN
More informationScreening of the mutations in luteinizing hormone p-subunit in patients with menstrual disorders*
FERTILITY AND STERILITY Copyright e 1995 American Society for Reproductive Medicine Printed on acid-free paper in U. s. A. Screening of the mutations in luteinizing hormone p-subunit in patients with menstrual
More informationDr Stella Milsom. Endocrinologist Fertility Associates Auckland. 12:30-12:40 When Puberty is PCO
Dr Stella Milsom Endocrinologist Fertility Associates Auckland 12:30-12:40 When Puberty is PCO Puberty or Polycystic Ovary Syndrome? Stella Milsom Endocrinologist Auckland DHB, University of Auckland,
More informationDetermining the insulin resistance rate in Polycystic Ovary Syndrome patients (PCOs)
Abstract: Determining the insulin resistance rate in Polycystic Ovary Syndrome patients (PCOs) Ashraf Olabi, Ghena Alqotini College of medicine, Aleppo University Hospital Obstetrics and Gynacology, Syria.
More informationMetformin in early pregnancy and abortions. Laure Morin-Papunen, MD, PhD Dept. of Obstetrics and Gynecology University Hospital of Oulu, Finland
Metformin in early pregnancy and abortions Laure Morin-Papunen, MD, PhD Dept. of Obstetrics and Gynecology University Hospital of Oulu, Finland PCOS and miscarriage risk Metformin and miscarriage risk
More informationDiagnostic Performance of Serum Total Testosterone for Japanese Patients with Polycystic Ovary Syndrome
Endocrine Journal 2007, 54 (2), 233 238 Diagnostic Performance of Serum Total Testosterone for Japanese Patients with Polycystic Ovary Syndrome TAKESHI IWASA, TOSHIYA MATSUZAKI, MASAHIRO MINAKUCHI, NAOKO
More informationA STUDY OF CLINICAL PARAMETERS IN THE DIAGNOSIS OF POLYCYSTIC OVARIAN SYNDROME Soumya Ranjan Panda 1, K. Durgavati 2, Santhosh Kumar Sahu 3
A STUDY OF CLINICAL PARAMETERS IN THE DIAGNOSIS OF POLYCYSTIC OVARIAN SYNDROME Soumya Ranjan Panda 1, K. Durgavati 2, Santhosh Kumar Sahu 3 HOW TO CITE THIS ARTICLE: Soumya Ranjan Panda, Durgavati K, Santhosh
More informationEndocrine abnormalities in ovulatory women with polycystic ovaries on ultrasound
Human Reproduction vol.12 no.5 pp. 905 909, 1997 Endocrine abnormalities in ovulatory women with polycystic ovaries on ultrasound E.Carmina 1, L.Wong 2, L.Chang 2, R.J.Paulson 2, disturbance of the IGF/IGFBP-l
More informationWHY NEW DIAGNOSTIC CRITERIA FOR DIFFERENT PCOS PHENOTYPES ARE URGENTLY NEEDED
WHY NEW DIAGNOSTIC CRITERIA FOR DIFFERENT PCOS PHENOTYPES ARE URGENTLY NEEDED Ricardo Azziz, M.D., M.P.H., M.B.A. Chief Officer of Academic Health & Hospital Affairs State University of New York (SUNY)
More informationPrevalence of polycystic ovarian syndrome in the Buraimi region of Oman
Original Article Brunei Int Med J. 2012; 8 (5): 248-252 Prevalence of polycystic ovarian syndrome in the Buraimi region of Oman Usha VARGHESE 1 and Shaji VARUGHESE 2, 1 Department of Internal Medicine
More informationRelation of luteinizing hormone levels to body mass index in premenopausal women
FERTILITY AND STERILITY VOL. 69, NO. 3, MARCH 1998 Copyright 1998 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Relation of luteinizing
More informationROLE OF METFORMIN IN POLYCYSTIC OVARIAN SYNDROME
ORIGINAL ARTICLE ROLE OF METFORMIN IN POLYCYSTIC OVARIAN SYNDROME 1 2 3 Samdana Wahab, Farnaz, Rukhsana Karim ABSTRACT Objective: To assess the role of Metformin in Polycystic ovarian syndrome (PCOS).
More informationClinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes
POLYCYSTIC OVARY SYNDROME Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes Ettore Guastella, M.D., a Rosa Alba Longo, M.D., b and Enrico Carmina, M.D. b a Department
More informationSCREENING OF POLYCYSTIC OVARIAN SYNDROME AMONG ADOLESCENT GIRLS AT CAIRO UNIVERSITY
SCREENING OF POLYCYSTIC OVARIAN SYNDROME AMONG ADOLESCENT GIRLS AT CAIRO UNIVERSITY Sahar Mansour Ibrahim, Yossria Ahmed Elsayed, Reda Esmail Reyad 4 and Hanan Fahmy Azzam 1* 2 3 1 Assistant Lecturer,
More informationPoly cystic ovary syndrome: the spectrum of the disorder in 1741 patients
Human Reproduction vol.10 no.8 pp.21o7-2111, 1995 Poly cystic ovary syndrome: the spectrum of the disorder in 1741 patients Adam H. Balen 1, Gerry S.Conway, Gregory Kaltsas, Kitirak Techatraisak, Patrick
More informationDiabetes and Cardiovascular Risks in the Polycystic Ovary Syndrome
Diabetes and Cardiovascular Risks in the Polycystic Ovary Syndrome John E. Nestler, M.D. William Branch Porter Professor of Medicine Chair, Department of Internal Medicine Virginia Commonwealth University
More informationMetformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome
FERTILITY AND STERILITY VOL. 69, NO. 4, APRIL 1998 Copyright 1998 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Metformin therapy improves
More informationPrevalence of Anovulation in Subfertile Women in Kerbala 2012, A descriptive Cross-Sectional Study
Prevalence of Anovulation in Subfertile Women in Kerbala 2012, A descriptive Cross-Sectional Study Mousa Mohsen Ali* Wasan Ghazi* HayderAamerAbboud^ *Kerbala University, College of Medicine, Gynecology
More informationPolycystic Ovarian Syndrome: Diagnosis, Preconceptional Management and Health Risks
Polycystic Ovarian Syndrome: Diagnosis, Preconceptional Management and Health Risks Kate D. Schoyer, M.D. May 6, 2016 Objectives To review how to make the diagnosis of Polycystic Ovarian Syndrome (PCOS)
More informationReproductive Health in Non Alcoolic Fatty Liver Disease (NAFLD)
Reproductive Health in Non Alcoolic Fatty Liver Disease (NAFLD) Pr Sophie Christin-Maitre Reproductive Endocrine Unit, Hôpital Saint-Antoine, AP-HP Université Pierre et Marie Curie INSERM U933 Paris, France
More informationPolycystic Ovarian Syndrome: Diagnosis, Preconceptional Management and Health Risks. Kate D. Schoyer, M.D. May 6, 2016
Polycystic Ovarian Syndrome: Diagnosis, Preconceptional Management and Health Risks Kate D. Schoyer, M.D. May 6, 2016 Objectives To review how to make the diagnosis of Polycystic Ovarian Syndrome (PCOS)
More informationASSOCIATION OF INSULIN RESISTANCE AND SERUM 25 OH VITAMIN-D IN INDIAN WOMEN WITH POLYCYSTIC OVARY SYNDROME
RESEARCH ARTICLE ASSOCIATION OF INSULIN RESISTANCE AND SERUM 25 OH VITAMIN-D IN INDIAN WOMEN WITH POLYCYSTIC OVARY SYNDROME Amar Nagesh Kumar 1, Jupalle Nagaiah Naidu 2, Uppala Satyanarayana 3, Medabalmi
More informationCARDIOVASCULAR EVENTS IN POLYCYSTIC OVARY SYNDROME
CARDIOVASCULAR EVENTS IN POLYCYSTIC OVARY SYNDROME Enrico Carmina Executive Director & CEO of Androgen Excess & PCOS Society Professor of Endocrinology Department of Health Sciences and Mother and Child
More informationCan Sex hormone Binding Globulin Considered as a Predictor of Response to Pharmacological Treatment in Women with Polycystic Ovary Syndrome?
www.ijpm.in www.ijpm.ir Can Sex hormone Binding Globulin Considered as a Predictor of Response to Pharmacological Treatment in Women with Polycystic Ovary Syndrome? Ferdous Mehrabian, Maryam Afghahi Department
More informationFSH pharmacogenetics
5th World Congress on Ovulation Induction Roma, 13 15 September 2007 FSH pharmacogenetics Hermann M. Behre Center of Reproductive Medicine and Andrology, University Hospital Halle, Germany & Manuela Simoni
More informationclinical outcome and hormone profiles before and after laparoscopic electroincision of the ovaries in women with polycystic ovary syndrome
& clinical outcome and hormone profiles before and after laparoscopic electroincision of the ovaries in women with polycystic ovary syndrome Zulfo Godinjak¹*, Ranka Javorić² 1 Gynecology and Obstetrics
More informationReproductive FSH. Analyte Information
Reproductive FSH Analyte Information 1 Follicle-stimulating hormone Introduction Follicle-stimulating hormone (FSH, also known as follitropin) is a glycoprotein hormone secreted by the anterior pituitary
More informationPolymorphism of the PAI-1gene (4G/5G) may be linked with Polycystic Ovary Syndrome and associated pregnancy disorders in South Indian Women
www.bioinformation.net Volume 13(5) Hypothesis Polymorphism of the PAI-1gene (4G/5G) may be linked with Polycystic Ovary Syndrome and associated pregnancy disorders in South Indian Women Maniraja Jesintha
More informationClinical Profile Polycystic Ovarian Syndrome Cases
ORIGINAL RESEARCH www.ijcmr.com - 100 Cases Himabindu Sangabathula 1, Neelima Varaganti 1 ABSTRACT Introduction: Polycystic ovary syndrome (PCOS) is most common endocrine disorders of reproductive age
More informationTHYROID PROFILE IN POLYCYSTIC OVARIAN SYNDROME Sudhanshu Sekhara Nanda 1, Subhalaxmi Dash 2, Ashok Behera 3, Bharati Mishra 4
THYROID PROFILE IN POLYCYSTIC OVARIAN SYNDROME Sudhanshu Sekhara Nanda 1, Subhalaxmi Dash 2, Ashok Behera 3, Bharati Mishra 4 HOW TO CITE THIS ARTICLE: Sudhanshu Sekhara Nanda, Subhalaxmi Dash, Ashok Behera,
More informationOverview of Reproductive Endocrinology
Overview of Reproductive Endocrinology I have no conflicts of interest to report. Maria Yialamas, MD Female Hypothalamic--Gonadal Axis 15 4 Hormone Secretion in the Normal Menstrual Cycle LH FSH E2, Progesterone,
More informationRotterdam Criteria 9/30/2017. A Changing Paradigm in PCOS. Polycystic Ovary Syndrome - Is the Cardiometabolic Risk Increased After Menopause?
Disclosure Polycystic Ovary Syndrome - Is the Cardiometabolic Risk Increased After Menopause? Fractyl laboratories, Inc Anuja Dokras, MD., Ph.D. Professor of Obstetrics and Gynecology Director PENN PCOS
More informationS. AMH in PCOS Research Insights beyond a Diagnostic Marker
S. AMH in PCOS Research Insights beyond a Diagnostic Marker Dr. Anushree D. Patil, MD. DGO Scientist - D National Institute for Research in Reproductive Health (Indian Council of Medical Research) (Dr.
More informationCREATING A PCOS TREATMENT PLAN. Ricardo Azziz, M.D., M.P.H., M.B.A. Georgia Regents University
CREATING A PCOS TREATMENT PLAN Ricardo Azziz, M.D., M.P.H., M.B.A. Georgia Regents University PCOS: CREATING A TREATMENT PLAN Good treatment plans are based on sound and complete evaluations History of
More informationLUCIAN BLAGA UNIVERSITY FROM SIBIU FACULTY OF MEDICINE VICTOR PAPILIAN INSULIN RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME SUMMARY
LUCIAN BLAGA UNIVERSITY FROM SIBIU FACULTY OF MEDICINE VICTOR PAPILIAN INSULIN RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME SUMMARY Scientific coordinator: Dr. Ion Gh. Totoian Ph.D. PhD student: Florina Ioana
More informationAmenorrhoea: polycystic ovary syndrome
There is so much we don't know in medicine that could make a difference, and often we focus on the big things, and the little things get forgotten. To highlight some smaller but important issues, we've
More informationFemale Reproductive Endocrinology
Female Reproductive Endocrinology Dr. Channa Jayasena PhD MRCP FRCPath Clinical Senior Lecturer & Consultant Endocrinologist Department of Gynaecology, Hammersmith Hospital Anovulation is a common cause
More informationReproductive outcome in women with body weight disturbances
Reproductive outcome in women with body weight disturbances Zeev Shoham M.D. Dep. Of OB/GYN Kaplan Hospital, Rehovot, Israel Weight Status BMI (kg/m 2 ) Underweight
More informationWEIGHT CHANGE AND ANDROGEN LEVELS DURING CONTRACEPTIVE TREATMENT OF WOMEN AFFECTED BY POLYCYSTIC OVARY
ENDOCRINE REGULATIONS, VOL. 40, 119-123, 2006 119 WEIGHT CHANGE AND ANDROGEN LEVELS DURING CONTRACEPTIVE TREATMENT OF WOMEN AFFECTED BY POLYCYSTIC OVARY J. VRBIKOVA, K. DVORAKOVA, M. HILL, L. STARKA Institute
More informationPregnancy outcome in women with polycystic ovary syndrome
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Nivedhitha VS et al. Int J Reprod Contracept Obstet Gynecol. 2015 Aug;4(4):1169-1175 www.ijrcog.org pissn 2320-1770 eissn
More informationNitasha Garg 1 Harkiran Kaur Khaira. About the Author
https://doi.org/10.1007/s13224-017-1082-4 ORIGINAL ARTICLE A Comparative Study on Quantitative Assessment of Blood Flow and Vascularization in Polycystic Ovary Syndrome Patients and Normal Women Using
More informationX/06/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 91(1):2 6 Copyright 2006 by The Endocrine Society doi: /jc.
0021-972X/06/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 91(1):2 6 Printed in U.S.A. Copyright 2006 by The Endocrine Society doi: 10.1210/jc.2005-1457 EXTENSIVE CLINICAL EXPERIENCE Relative
More informationORIGINAL ARTICLE Establishing the cut off values of androgen markers in the assessment of polycystic ovarian syndrome
Malaysian J Pathol 2018; 40(1) : 33 39 ORIGINAL ARTICLE Establishing the cut off values of androgen markers in the assessment of polycystic ovarian syndrome R N Dineshinee NADARAJA MBBS, Pavai STHANESHWAR
More informationInvestigation of adrenal functions in patients with idiopathic hyperandrogenemia
European Journal of Endocrinology (26) 155 37 311 ISSN 84-4643 CLINICAL STUDY Investigation of adrenal functions in patients with idiopathic hyperandrogenemia Hulusi Atmaca, Fatih Tanriverdi 1, Kursad
More informationPolycystic Ovary Syndrome
Polycystic Ovary Syndrome Definition: the diagnostic criteria Evidence of hyperandrogenism, biochemical &/or clinical (hirsutism, acne & male pattern baldness). Ovulatory dysfunction; amenorrhoea; oligomenorrhoea
More informationOriginal Investigation. 94 Endocrine Oncology and Metabolism. Jovanovska et al
Original Investigation Sensitivity and specificity of anti-mülerian hormone in the diagnosis of polycystic ovary syndrome in a macedonian population of women of reproductive age: a cross-sectional study
More informationEffect of troglitazone on endocrine and ovulatory performance in women with insulin resistance related polycystic ovary syndrome
FERTILITY AND STERILITY VOL. 71, NO. 2, FEBRUARY 1999 Copyright 1999 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Effect of troglitazone
More informationPrevalence of Polycystic Ovarian Syndrome among urban adolescent girls and young women in Mumbai
Prevalence of Polycystic Ovarian Syndrome among urban adolescent girls and young women in Mumbai Principal Investigator Co- Investigators Consultant Collaborating Hospital Dr. Beena Joshi Dr. Srabani Mukherji
More informationPolycystic Ovary Syndrome
What is the polycystic ovary syndrome? Polycystic Ovary Syndrome The polycystic ovary syndrome (PCOS) is a clinical diagnosis characterized by the presence of two or more of the following features: irregular
More informationCase Questions. Polycystic Ovarian Syndrome: Treatment Goals and Options. Differential Diagnosis of Hyperandrogenic Anovulation
Polycystic Ovarian Syndrome: Treatment Goals and Options Marc Cornier, MD Division of Endocrinology, Metabolism and Diabetes Colorado Center for Health and Wellness University of Colorado School of Medicine
More informationJMSCR Vol 05 Issue 05 Page May 2017
www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i5.14 Hyperinsulinemia in Polycystic Ovary Syndrome
More informationCLINICAL, BIOCHEMICAL AND ULTRASONOGRAPHIC FEATURES OF INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
ORIGINAL ARTICLE CLINICAL, BIOCHEMICAL AND ULTRASONOGRAPHIC FEATURES OF INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME Fauzia Haq, Omar Aftab* and Javed Rizvi ABSTRACT Objective: To evaluate and compare
More informationJMSCR Vol 05 Issue 04 Page April 2017
www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i4.228 Study of Cutaneous Manifestations of
More informationValidation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary syndrome
Validation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary syndrome Madelon van Wely, Ph.D., a Bart C. J. M. Fauser, M.D., Ph.D., b Joop S. E. Laven,
More informationClinical, biochemical and ultrasonographic characteristics of Scandinavian women with PCOS
Acta Obstet Gynecol Scand 2004: 83: 482--486 Copyright # Acta Obstet Gynecol Scand 2004 Printed in Denmark. All rights reserved Acta Obstetricia et Gynecologica Scandinavica ORIGINAL ARTICLE Clinical,
More informationPCOS and Obesity DUB is better treated by OCPs
PCOS and Obesity DUB is better treated by OCPs Dr. Ritu Joshi Senior consultant Fortis escorts Hospital, Jaipur Chairperson Family welfare com. FOGSI (20092012) Vice President FOGSI 2014 Introduction One
More informationCan high serum anti-müllerian hormone levels predict the phenotypes of polycystic ovary syndrome (PCOS) and metabolic disturbances in PCOS patients?
ORIGINAL ARTICLE http://dx.doi.org/1.5653/cerm.213.4.3.135 pissn 2233-8233 eissn 2233-8241 Clin Exp Reprod Med 213;4(3):135-14 Can high serum anti-müllerian hormone levels predict the phenotypes of polycystic
More informationJMSCR Vol 07 Issue 01 Page January 2019
www.jmscr.igmpublication.org Impact Factor (SJIF): 6.379 Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v7i1.55 Original Research Article A Study
More informationEndocrine control of female reproductive function
Medicine School of Women s & Children s Health Discipline of Obstetrics & Gynaecology Endocrine control of female reproductive function Kirsty Walters, PhD Fertility Research Centre, School of Women s
More informationEbtisam S. S. Al-Mizyen, M.B. Ch.B., M. Phil. * Jurgis G. Grudzinskas, M.D., F.R.C.O.G., F.R.A.C.O.G., B.Sc., M.B., B.S.
Middle East Fertility Society Journal Vol. 12, No. 3, 27 Copyright Middle East Fertility Society Ultrasonographic observations following unilateral and bilateral laparoscopic ovarian diathermy in infertile
More informationHyperandrogenism, PCOS and obesity after menopause : Meet the experts. Polycystic ovaries beyond menopause
Hyperandrogenism, PCOS and obesity after menopause : Meet the experts Polycystic ovaries beyond menopause Serge Rozenberg CHU St Pierre Université libre de Bruxelles, Vrije Universiteit Brussel Belgium
More informationClinical Manifestations of the Polycystic Ovary Syndrome at Menopausal Age
American Journal of Medicine and Medical Sciences 2019, 9(1): 35-39 DOI: 10.5923/j.ajmms.20190901.06 Clinical Manifestations of the Polycystic Ovary Syndrome at Menopausal Age Gafurova F. A. Assistant
More information12/13/2017. Important references for PCOS. Polycystic Ovarian Syndrome (PCOS) for the Family Physician. 35 year old obese woman
Polycystic Ovarian Syndrome (PCOS) for the Family Physician Barbara S. Apgar MD, MS Professor or Family Medicine University of Michigan Ann Arbor, Michigan Important references for PCOS Endocrine Society
More informationThe Impact of Insulin Resistance on Long-Term Health in PCOS
Saturday, April 16 th, 2016 PCOS Challenge & Thomas Jefferson University PCOS Awareness Symposium Philadelphia The Impact of Insulin Resistance on Long-Term Health in PCOS Katherine Sherif, MD Professor
More informationPolycystic ovarian syndrome: Are radiology departments contributing to the misdiagnosis?
Polycystic ovarian syndrome: Are radiology departments contributing to the misdiagnosis? Poster No.: C-1238 Congress: ECR 2010 Type: Scientific Exhibit Topic: Genitourinary Authors: G. Tony, N. V. Gurjar,
More informationIMPACT OF NUTRITION ON GYNECOLOGICAL HEALTH OF FEMALE ADOLESCENTS
IMPACT OF NUTRITION ON GYNECOLOGICAL HEALTH OF FEMALE ADOLESCENTS Kedikova S. MD, PhD Medical University Sofia, Bulgaria University Hospital Maichin dom Sofia NUTRITION WHO - Nutrition is the intake of
More informationMetformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome
IJMS Vol 36, No 2, June 2011 Original Article Metformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome Marzieh Farimani Sanoee 1, Nosrat Neghab 1, Soghra
More informationDoes free androgen index predict subsequent pregnancy outcome in women with recurrent miscarriage?
Human Reproduction Vol.23, No.4 pp. 797 802, 2008 Advance Access publication on February 8, 2008 doi:10.1093/humrep/den022 Does free androgen index predict subsequent pregnancy outcome in women with recurrent
More informationPolycystic ovarian disease: heritability and heterogeneity
Human Reproduction Update, Vol.7, No.1 pp. 3±7, 2001 Polycystic ovarian disease: heritability and heterogeneity P.G.Crosignani 1 and A.E.Nicolosi Department of Obstetrics and Gynecology, University of
More informationComparative study of metabolic profile of women presenting with polycystic ovary syndrome in relation to body mass index
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Akshaya S et al. Int J Reprod Contracept Obstet Gynecol. 2016 Aug;5(8):2561-2565 www.ijrcog.org pissn 2320-1770 eissn 2320-1789
More informationWe are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 4,000 116,000 120M Open access books available International authors and editors Downloads Our
More informationThe (TAAAA) n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome
Human Reproduction Vol.22, No.4 pp. 1031 1036, 2007 Advance Access publication December 22, 2006 doi:10.1093/humrep/del457 The (TAAAA) n microsatellite polymorphism in the SHBG gene influences serum SHBG
More informationTreatment of hirsutism with a gonadotropin-releasing hormone agonist and estrogen replacement therapy*
Gynecology-endocrinology FERTILITY AND STERILITY Copyright 1994 The American Fertility Society Printed on acid-free paper in U S. A. Treatment of hirsutism with a gonadotropin-releasing hormone agonist
More informationNature and Science 2017;15(8)
Prognostic Value of Day 3 Luteinising Hormone (LH) in the prediction of Ovarian Response in Patients with Polycystic Ovary syndrome Mohammed Samir Fouad 1 ; Mohammed Said El-Shorbagy 2, Mohammed Mohammed
More informationPolycystic Ovary Syndrome (PCOS):
Polycystic Ovary Syndrome (PCOS): Current diagnosis and treatment Anatte E. Karmon, MD Disclosures- Anatte Karmon, MD No financial relationships to disclose 2 Objectives At the end of this presentation,
More informationSUPPLEMENTARY FIGURES
SUPPLEMENTARY FIGURES Supplementary Figure 1 Regional association plots for genome-wide significant PCOS signals. Dots represents individual SNP association P-values (on the log10 scale) in the 23andMe
More information3. Metformin therapy for PCOS
1. Introduction The key clinical features of polycystic ovary syndrome (PCOS) are hyperandrogenism (hirsutism, acne, alopecia) and menstrual irregularity with associated anovulatory infertility. 1 The
More informationInsulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogeneous group of disorders
FERTILITY AND STERILITY VOL. 72, NO. 1, JULY 1999 Copyright 1999 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Insulin, androgens, and
More informationOriginal Research Article
Original Research Article Polycystic Ovarian Syndrome: A Hormonal and Radiological Correlation Haque Riyajul Aqbalul Nazma Begum 1, K Ashoka Reddy 2, Md. Kaleemullah 3 1 Final Year Post Graduate, 2 Senior
More informationAbstract. Introduction. RBMOnline - Vol 10. No Reproductive BioMedicine Online; on web 15 November 2004
RBMOnline - Vol 10. No 1. 2005 100-104 Reproductive BioMedicine Online; www.rbmonline.com/article/1484 on web 15 November 2004 Article Metformin monotherapy in lean women with polycystic ovary syndrome
More informationDEFINING THE POLYCYSTIC ovary syndrome (PCOS)
0021-972X/06/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 91(10):3922 3927 Printed in U.S.A. Copyright 2006 by The Endocrine Society doi: 10.1210/jc.2006-1054 Oligoanovulation with Polycystic
More informationStudy of clinical presentation in cases of Polycystic Ovarian Syndrome in rural population
Original article: Study of clinical presentation in cases of Polycystic Ovarian Syndrome in rural population 1Dr Shalini Kanotra, 2 Dr Nikita Singh*, 3 Dr V B Bangal 1 Associate Professor, OBGY Department,
More informationMetabolic changes in menopausal transition
Metabolic changes in menopausal transition Terhi T. Piltonen M.D., Associate Professor Consultant, Clinical Researcher for the Finnish Medical Foundation Department of Obstetrics and Gynecology PEDEGO
More informationREPRODUCTIVE BIOLOGY. University of Oulu, Oulu, Finland
REPRODUCTIVE BIOLOGY FERTILITY AND STERILITY VOL. 78, NO. 1, JULY 2002 Copyright 2002 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A.
More informationPolycystic Ovary Syndrome HEATHER BURKS, MD OU PHYSICIANS REPRODUCTIVE MEDICINE SEPTEMBER 21, 2018
Polycystic Ovary Syndrome HEATHER BURKS, MD OU PHYSICIANS REPRODUCTIVE MEDICINE SEPTEMBER 21, 2018 Learning Objectives At the conclusion of this lecture, learners should: 1) Know the various diagnostic
More informationScreening non-classical 21-hydroxylase gene deficiency from patients diagnosed as polycystic ovary syndrome by gene assay HU Jie, JIAO Kai *
Med J Chin PLA, Vol. 41, No. 3, March 1, 2016 227 21- [ ] (PCOS) 21- (NC-21OHD) 2014 2015 98 PCOS Ferriman-Gallway ( mf-g ) 3 mf-g 0~2 A 3~5 B 6 C30 DNA 5 CYP21A2 8 (ACTH) 30 98 PCOS 5 V281L/920-921insT(P1)
More informationCam type Femoroacetabular Impingement associated with Marker for Hyperandrogenism in Women
Cam type Femoroacetabular Impingement associated with Marker for Hyperandrogenism in Women Andrew B. Wolff, MD a Torie Plowden, MD b Alexandra Napoli, BA a Benjamin McArthur, MD a Erin F. Wolff, MD b a
More informationA study of clinical manifestations of PCOS among obese and non- obese rural women
Original article: A study of clinical manifestations of PCOS among obese and non- obese rural women 1Kala k.*, 2 Sujata N Datti, 3 Sujatha C., 4 Dayanand R., 5 Kumar Guruprasad G A 1Assistant professor,
More informationInternational Journal of Health Sciences and Research ISSN:
International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article A Study on Assessment of Testosterone, Insulin Resistance and HbA1c in Women with Polycystic
More informationDoppler flow velocities of uterine and ovarian arteries & hormonal patterns in patients with Polycystic Ovary Syndrome (PCOS)
Original article: Doppler flow velocities of uterine and ovarian arteries & hormonal patterns in patients with Polycystic Ovary Syndrome (PCOS) Dr. Deepali Dhingra*#, Dr. Shashi Prateek*, Dr. Renuka Sinha*,
More informationThe Effect of Vitamin D Replacement Therapy on Serum Leptin and Follicular Growth Pattern in Women with Clomiphene Citrate Resistant Polycystic Ovary
Med. J. Cairo Univ., Vol. 84, No. 2, June: 85-89, 2016 www.medicaljournalofcairouniversity.net The Effect of Vitamin D Replacement Therapy on Serum Leptin and Follicular Growth Pattern in Women with Clomiphene
More informationEndometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome
ORIGINAL ARTICLE pissn 2233-8233 eissn 2233-8241 Clin Exp Reprod Med 2011;38(1):42-46 Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome
More informationWhat every dermatologist should know about Polycystic Ovary Syndrome (PCOS)
What every dermatologist should know about Polycystic Ovary Syndrome (PCOS) Kanade Shinkai, MD PhD University of California, San Francisco Associate Professor of Dermatology I have no conflicts of interest
More information