TITLE: Culture Media for Various Assisted Reproduction Procedures: Clinical Effectiveness
|
|
- Quentin Hensley
- 6 years ago
- Views:
Transcription
1 TITLE: Culture Media for Various Assisted Reproduction Procedures: Clinical Effectiveness DATE: 02 February 2010 RESEARCH QUESTION: What is the evidence of the effectiveness of different culture media for the various assisted reproduction procedures for gamete and embryo viability? METHODS: A limited literature search was conducted on key health technology assessment resources, including PubMed, the Cochrane Library (Issue 1, 2010), University of York Centre for Reviews and Dissemination (CRD) databases, ECRI, EuroScan, international health technology agencies, and a focused Internet search. The search was limited to English language articles published between 2005 and January No filters were applied to limit the retrieval by study type. Internet links were provided, where available. The summary of findings was prepared from the abstracts of the relevant information. Please note that data contained in abstracts may not always be an accurate reflection of the data contained within the full article. RESULTS: HTIS reports are organized so that the higher quality evidence is presented first. Therefore, health technology assessment reports, systematic reviews, and meta-analyses are presented first. These are followed by randomized controlled trials, controlled clinical trials, and observational studies. One systematic review and six randomized controlled trials were identified regarding the effectiveness of different culture media for the various assisted reproduction procedures for gamete and embryo viability. No health technology assessments were identified. Due to the availability of studies associated with higher internal validity, controlled clinical trials and Disclaimer: The Health Technology Inquiry Service (HTIS) is an information service for those involved in planning and providing health care in Canada. HTIS responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. HTIS responses should be considered along with other types of information and health care considerations. The information included in this response is not intended to replace professional medical advice, nor should it be construed as a recommendation for or against the use of a particular health technology. Readers are also cautioned that a lack of good quality evidence does not necessarily mean a lack of effectiveness particularly in the case of new and emerging health technologies, for which little information can be found, but which may in future prove to be effective. While CADTH has taken care in the preparation of the report to ensure that its contents are accurate, complete and up to date, CADTH does not make any guarantee to that effect. CADTH is not liable for any loss or damages resulting from use of the information in the report. Copyright: This report contains CADTH copyright material and may contain material in which a third party owns copyright. This report may be used for the purposes of research or private study only. It may not be copied, posted on a web site, redistributed by or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners own terms and conditions.
2 observational studies were moved to the appendix. Additional articles of potential interest may also be found in the appendix. OVERALL SUMMARY OF FINDINGS: A systematic review of the effectiveness of assisted reproductive technology concluded that there was not enough available evidence to provide a firm conclusion regarding the impact of differing culture media on assisted reproduction outcomes. 1 The six identified randomized controlled trials 2-7 presented outcomes from various culture and transfer media and are summarized in Table 1. The results from four of the six randomized controlled trials favored the study group. 2,3,5,6 Author de Araujo et al. 2 Meintjes et al. 3 Ge et al. 4 Hashimoto et al. 5 Friedler et al. 6 Mahani et al. 7 Table 1: Summary results of included RCTs Patient Study group Comparator population group Women with Human tubal fluid PCOS Couples routine IVF or ICSI Women with PCOS Women IVF/ET Women IVF/ET after failed transfer Women IVF/ET Supplemented tissue culture medium 199 supplemented with HSA + SSS with hcg with a novel stable glutamine derivative + vitamins medium with hyaluronan medium with hyaluronic acid supplemented with HSA without hcg with L-glutamine medium without hyaluronan medium with albumin Outcomes Significant increase in maturation rate, fertilization rate, and embryo quality in the study group Overall increase in implantation and birth rates in the study group Maturation rate and developmental potential of oocytes were not improved in the study group Significant increase in blastulation rate on day 5 and 6, supporting development of the embryo, in the study group Significantly higher implantation rate; and, significantly higher clinical, continuing, and delivered pregnancy rate in the study group Pregnancy rates were not significantly different between groups and the two media can be used interchangeably PCOS = polycystic ovary syndrome; IVF = in vitro fertilization; ICSI = intracyoplasmic sperm injection; HAS = human serum albumin; SSS = serum substitute supplement; hcg = human gonadotropin; ET = embryo transfer Culture Media for Assisted Reproduction 2
3 REFERENCES SUMMARIZED: Health technology assessments No literature identified Systematic reviews and meta-analyses 1. Myers ER, McCrory DC, Mills AA, Price TM, Swamy GK, Tantibhedhyangkul J, et al. Effectiveness of assisted reproductive technology. evidence report/technology assessment no [Internet]. Rockville (MD): Agency for Healthcare Research and Quality; [cited 2010 Jan 20]. Available from: Note: see last paragraph p. 71, and B. Embryo culture p. 89 Randomized controlled trials 2. de Araujo CH, Nogueira D, de Araujo MC, Martins Wde P, Ferriani RA, dos Reis RM. Supplemented tissue culture medium 199 is a better medium for in vitro maturation of oocytes from women with polycystic ovary syndrome women than human tubal fluid. Fertil Steril Feb;91(2): PubMed: PM Meintjes M, Chantilis SJ, Ward DC, Douglas JD, Rodriguez AJ, Guerami AR, et al. A randomized controlled study of human serum albumin and serum substitute supplement as protein supplements for IVF culture and the effect on live birth rates. Hum Reprod Apr;24(4): PubMed: PM Ge HS, Huang XF, Zhang W, Zhao JZ, Lin JJ, Zhou W. Exposure to human chorionic gonadotropin during in vitro maturation does not improve the maturation rate and developmental potential of immature oocytes from patients with polycystic ovary syndrome. Fertil Steril Jan;89(1): PubMed: PM Hashimoto S, Nishihara T, Murata Y, Oku H, Nakaoka Y, Fukuda A, et al. Medium without ammonium accumulation supports the developmental competence of human embryos. J Reprod Dev Oct;54(5): PubMed: PM Friedler S, Schachter M, Strassburger D, Esther K, Ron-El R, Raziel A. A randomized clinical trial comparing recombinant hyaluronan/recombinant albumin versus human tubal fluid for cleavage stage embryo transfer in patients with multiple IVF-embryo transfer failure. Hum Reprod Sep;22(9): PubMed: PM Mahani IM, Davar R. Hyaluronic acid versus albumin in human embryo transfer medium. East Mediterr Health J Jul;13(4): PubMed: PM Available from: Culture Media for Assisted Reproduction 3
4 PREPARED BY: Michelle Clark, BSc, Research Assistant Jessie Cunningham, MISt, Information Specialist Health Technology Inquiry Service Tel: Culture Media for Assisted Reproduction 4
5 APPENDIX FURTHER INFORMATION: Controlled clinical trials 8. Aoki VW, Wilcox AL, Peterson CM, Parker-Jones K, Hatasaka HH, Gibson M, et al. Comparison of four media types during 3-day human IVF embryo culture. Reprod Biomed Online May;10(5): PubMed: PM Observational studies 9. Reed ML, Hamic A, Thompson DJ, Caperton CL. Continuous uninterrupted single medium culture without medium renewal versus sequential media culture: a sibling embryo study. Fertil Steril Nov;92(5): PubMed: PM Filali M, Hesters L, Fanchin R, Tachdjian G, Frydman R, Frydman N. Retrospective comparison of two media for invitro maturation of oocytes. Reprod Biomed Online Feb;16(2): PubMed: PM Jee BC, Han SH, Moon JH, Suh CS, Kim SH, Seoul National University College of Medicine Assisted Reproductive Technology (SMART) Study Group. Influence of well defined protein source on in vitro maturation of human oocyte: human follicular fluid versus human serum albumin. Fertil Steril Feb;89(2): PubMed: PM Kanaya H, Fukuda A, Hashimoto S, Hosoi Y, Morimoto Y. In vitro maturation of human immature oocytes in culture medium supplemented with patient's own serum or donor follicular fluid. J Mamm Ova Res. [Internet] 2008 [cited 2010 Jan 20];25(3): Available from: Loutradi KE, Prassas I, Bili E, Sanopoulou T, Bontis I, Tarlatzis BC. Evaluation of a transfer medium containing high concentration of hyaluronan in human in vitro fertilization. Fertil Steril Jan;87(1): PubMed: PM Boldt J, Tidswell N, Sayers A, Kilani R, Cline D. Human oocyte cryopreservation: 5-year experience with a sodium-depleted slow freezing method. Reprod Biomed Online Jul;13(1): PubMed: PM Borini A, Sciajno R, Bianchi V, Sereni E, Flamigni C, Coticchio G. Clinical outcome of oocyte cryopreservation after slow cooling with a protocol utilizing a high sucrose concentration. Hum Reprod Feb;21(2): PubMed: PM Review articles 16. Biggers JD, Summers MC. Choosing a culture medium: making informed choices. Fertil Steril Sep;90(3): PubMed: PM Culture Media for Assisted Reproduction 5
6 17. Lane M, Gardner DK. Embryo culture medium: which is the best? Best Pract Res Clin Obstet Gynaecol Feb;21(1): PubMed: PM Maximizing the retention of antigen specific lymphocyte function after cryopreservation. J Immunol Methods Jan 20;308(1-2):13-8. PubMed: PM Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in female infertility - a clinician's perspective. Reprod Biomed Online Nov;11(5): PubMed: PM Culture Media for Assisted Reproduction 6
TITLE: Probenecid Dosing When Given with Cefazolin: Guidelines and Clinical Effectiveness
TITLE: Probenecid Dosing When Given with Cefazolin: Guidelines and Clinical Effectiveness DATE: 21 November 2008 RESEARCH QUESTIONS: 1. What is the evidence for the clinical effectiveness of the 1g dose
More informationTITLE: Vacuum Boards for Spinal Motion Restriction: Clinical Effectiveness
TITLE: Vacuum Boards for Spinal Motion Restriction: Clinical Effectiveness DATE: 14 October 2008 RESEARCH QUESTION: What are the clinical benefits and harms of using vacuum boards for spinal motion restriction?
More informationTITLE: Dose of Electrical Current for Biphasic Defibrillators for Synchronous Cardioversion in Patients with Tachyarrhythmia: Guidelines
TITLE: Dose of Electrical Current for Biphasic Defibrillators for Synchronous Cardioversion in Patients with Tachyarrhythmia: Guidelines DATE: 5 May 2009 RESEARCH QUESTION: What recommendations exist for
More informationTITLE: Use of Bupropion in Patients with Depression and the Associated Risk of Seizures: Safety
TITLE: Use of Bupropion in Patients with Depression and the Associated Risk of Seizures: Safety DATE: 1 April 2010 CONTEXT AND POLICY ISSUES: The prevalence of epilepsy ranges from 0.5% to 1%, 1,2 and
More informationTITLE: Discontinuation of Benzodiazepines and Other Sedative-Hypnotic Sleep Medication in Hospitalized Patients: Clinical Evidence and Guidelines
TITLE: Discontinuation of Benzodiazepines and Other Sedative-Hypnotic Sleep Medication in Hospitalized Patients: Clinical Evidence and Guidelines DATE: 25 September 2015 RESEARCH QUESTIONS 1. What is the
More informationTITLE: Naltrexone for the Treatment of Alcohol Dependence in Individuals with Co- Dependencies: A Review of the Clinical Effectiveness
TITLE: Naltrexone for the Treatment of Alcohol Dependence in Individuals with Co- Dependencies: A Review of the Clinical Effectiveness DATE: 08 October 2009 CONTEXT AND POLICY ISSUES: Poly-drug abuse is
More informationTITLE: Hyperbaric Oxygen Therapy for Autism: A Review of the Clinical and Cost- Effectiveness
TITLE: Hyperbaric Oxygen Therapy for Autism: A Review of the Clinical and Cost- Effectiveness DATE: 19 November 2009 CONTEXT AND POLICY ISSUES: Autism is a pervasive developmental disorder characterized
More informationTITLE: Type of Thermometer for Inpatients: Clinical-Effectiveness and Guidelines
TITLE: Type of Thermometer for Inpatients: Clinical-Effectiveness and Guidelines DATE: 28 May 2009 RESEARCH QUESTIONS: 1. What is the clinical-effectiveness of tympanic, temporal, oral, and rectal thermometers
More informationTITLE: Left Atrial Appendage Occlusion: Economic Impact and Existing HTA Recommendations
TITLE: Left Atrial Appendage Occlusion: Economic Impact and Existing HTA Recommendations DATE: 29 September 2010 CONTEXT AND POLICY ISSUES: Atrial fibrillation (AF) is the irregular, rapid beating of the
More informationTITLE: Hyperbaric Oxygen Therapy for Adults with Mental Illness: A Review of the Clinical Effectiveness
TITLE: Hyperbaric Oxygen Therapy for Adults with Mental Illness: A Review of the Clinical Effectiveness DATE: 27 August 2014 CONTEXT AND POLICY ISSUES Mental illness, including major depressive episode,
More informationTitle: Scoop Stretcher for Restriction of Spinal Motion: Clinical Effectiveness
Title: Scoop Stretcher for Restriction of Spinal Motion: Clinical Effectiveness Date: 28 May 2008 Research question: What is the evidence for the clinical effectiveness of a scoop stretcher to restrict
More informationDATE: 17 July 2012 CONTEXT AND POLICY ISSUES
TITLE: Sterile Pre-filled Saline Syringes for Acute Care Patients: A Review of Clinical Evidence, Cost-effectiveness, Evidence-based Guidelines, and Safety DATE: 17 July 2012 CONTEXT AND POLICY ISSUES
More informationDATE: 09 December 2009 CONTEXT AND POLICY ISSUES:
TITLE: Tiotropium Compared with Ipratropium for Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease: A Review of the Clinical Effectiveness DATE: 09 December 2009 CONTEXT AND POLICY
More informationTITLE: Patient-Controlled Analgesia for Acute Injury Transfers: A Review of the Clinical Effectiveness, Safety, and Guidelines
TITLE: Patient-Controlled Analgesia for Acute Injury Transfers: A Review of the Clinical Effectiveness, Safety, and Guidelines DATE: 11 August 2014 CONTEXT AND POLICY ISSUES Patient-controlled analgesia
More informationTITLE: Memantine in Combination with Cholinesterase Inhibitors for Alzheimer s Disease: Clinical Effectiveness
TITLE: Memantine in Combination with Cholinesterase Inhibitors for Alzheimer s Disease: Clinical Effectiveness DATE: 30 October 2008 RESEARCH QUESTION: What is the evidence for using memantine in combination
More informationTITLE: Delivery of Electroconvulsive Therapy in Non-Hospital Settings: A Review of the Safety and Guidelines
TITLE: Delivery of Electroconvulsive Therapy in Non-Hospital Settings: A Review of the Safety and Guidelines DATE: 08 May 2014 CONTEXT AND POLICY ISSUES Electroconvulsive therapy (ECT) is a treatment that
More informationTitle: Parenteral Iron Therapy for Anemia: A Clinical and Cost-Effectiveness Review
Title: Parenteral Iron Therapy for Anemia: A Clinical and Cost-Effectiveness Review Date: 14 February 2008 Context and policy issues: Anemia is a complication of chronic diseases and commonly occurs in
More informationDate: 23 June Context and policy issues:
Title: Basiliximab for Immunosuppression During a Calcineurin Inhibitor Holiday in Renal Transplant Patients with Acute Renal Dysfunction: Guidelines for Use and a Clinical and Cost-Effectiveness Review
More informationTitle: Elective Endovascular Abdominal Aortic Aneurism Repair versus Open Surgery: A Clinical and Cost Effectiveness Review
Title: Elective Endovascular Abdominal Aortic Aneurism Repair versus Open Surgery: A Clinical and Cost Effectiveness Review Date: 07 April 2008 Context and policy issues: Abdominal aortic aneurism (AAA)
More informationTITLE: Closed Catheter Systems for Prevention of Urinary Tract Infections: A Review of the Clinical Effectiveness
TITLE: Closed Catheter Systems for Prevention of Urinary Tract Infections: A Review of the Clinical Effectiveness DATE: 24 November 2008 CONTEXT AND POLICY ISSUES: Urinary tract infections (UTI) are the
More informationTitle: Re-using the Canister Portion of Metered Dose Inhalers in a Hospital Setting: Clinical Review of Safety, Cost-Effectiveness and Guidelines
Title: Re-using the Canister Portion of Metered Dose Inhalers in a Hospital Setting: Clinical Review of Safety, Cost-Effectiveness and Guidelines Date: 16 June 2008 Context and policy issues: A metered
More informationTitle: Shortened Dental Arch and Restorative Therapies: Evidence for Functional Dentition
Title: Shortened Dental Arch and Restorative Therapies: Evidence for Functional Dentition Date: 15 May 2008 Context and policy issues: For patients who lose teeth due to various reasons, a fundamental
More informationTITLE: Critical Incident Stress Debriefing for First Responders: A Review of the Clinical Benefit and Harm
TITLE: Critical Incident Stress Debriefing for First Responders: A Review of the Clinical Benefit and Harm DATE: 12 February 2010 CONTEXT AND POLICY ISSUES: Critical incident stress debriefing (CISD) is
More informationTITLE: Immediate Osseointegrated Implants for Cancer Patients: A Review of Clinical and Cost-Effectiveness
TITLE: Immediate Osseointegrated Implants for Cancer Patients: A Review of Clinical and Cost-Effectiveness DATE: 13 January 2015 CONTEXT AND POLICY ISSUES According to the World health Organization, the
More informationTITLE: Dental Loupes for Dental Procedures: A Review of the Clinical and Cost- Effectiveness
TITLE: Dental Loupes for Dental Procedures: A Review of the Clinical and Cost- Effectiveness DATE: 08 October 2008 CONTEXT AND POLICY ISSUES: The use of magnification in dentistry is expanding rapidly.
More informationTITLE: Montelukast for Sleep Apnea: A Review of the Clinical Effectiveness, Cost Effectiveness, and Guidelines
TITLE: Montelukast for Sleep Apnea: A Review of the Clinical Effectiveness, Cost Effectiveness, and Guidelines DATE: 17 January 2014 CONTEXT AND POLICY ISSUES Obstructive sleep apnea (OSA) is a common
More informationDATE: 04 April 2012 CONTEXT AND POLICY ISSUES
TITLE: Procedure Site Bleeding Complications Following Percutaneous Coronary Interventions or Angioplasty: A Review of Clinical Evidence and Guidelines DATE: 04 April 2012 CONTEXT AND POLICY ISSUES Percutaneous
More informationCADTH RAPID RESPONSE REPORT: REFERENCE LIST Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness
CADTH RAPID RESPONSE REPORT: REFERENCE LIST Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness Service Line: Rapid Response Service Version: 1.0 Publication Date: August
More informationTITLE: Australian Sheepskins for the Management of Pressure Ulcers: A Review of the Clinical-Effectiveness, Cost-Effectiveness, and Guidelines
TITLE: Australian Sheepskins for the Management of Pressure Ulcers: A Review of the Clinical-Effectiveness, Cost-Effectiveness, and Guidelines DATE: 21 July 2009 CONTEXT AND POLICY ISSUES: Pressure ulcers,
More informationTitle: Ultrasound for Breast Cancer Screening: Clinical Effectiveness. Date: 4 January Context and policy issues:
Title: Ultrasound for Breast Cancer Screening: Clinical Effectiveness Date: 4 January 2008 Context and policy issues: It is estimated that 22,300 women will be diagnosed with breast cancer and approximately
More informationThis report will provide a review on the comparative clinical effectiveness and safety between intranasal triamcinolone and beclomethasone.
TITLE: Intranasal Triamcinolone versus Intranasal Beclomethasone for Acute and Chronic Sinus Inflammation: A Review of Comparative Clinical Effectiveness and Safety DATE: 29 January 2013 CONTEXT AND POLICY
More informationService Line: Rapid Response Service Version: 1.0 Publication Date: January 21, 2019 Report Length: 5 Pages
CADTH RAPID RESPONSE REPORT: REFERENCE LIST Topical Cantharidin/ Salicylic Acid/ Podophyllin for the Treatment of Warts: Clinical Effectiveness and Guidelines Service Line: Rapid Response Service Version:
More informationService Line: Rapid Response Service Version: 1.0 Publication Date: June 12, 2018 Report Length: 5 Pages
CADTH RAPID RESPONSE REPORT: SUMMARY OF ABSTRACTS Sensory Rooms for Pediatric Patients with Neurocognitive Disorders: Clinical Effectiveness and Guidelines Service Line: Rapid Response Service Version:
More informationService Line: Rapid Response Service Version: 1.0 Publication Date: March 5, 2018 Report Length: 5 Pages
CADTH RAPID RESPONSE REPORT: REFERENCE LIST Oral Neomycin in Preparation for Colorectal Procedures: Clinical Effectiveness, Cost- Effectiveness and Guidelines Service Line: Rapid Response Service Version:
More informationEndometrial Preparation for Frozen Embryo Transfer (FET) Zitao Liu, MD, PhD New Hope Fertility Center, NY
Endometrial Preparation for Frozen Embryo Transfer (FET) Zitao Liu, MD, PhD New Hope Fertility Center, NY Natural Cycle FET Protocol for endometrial preparation N FET, including modified N FET HRT FET:
More informationTITLE: Fluoridated Water for Cavity Prevention: Clinical and Cost-Effectiveness and
TITLE: Fluoridated Water for Cavity Prevention: Clinical and Cost-Effectiveness and Guidelines DATE: 29 April 2009 RESEARCH QUESTIONS: 1. What is the evidence for the clinical benefit and safety of fluoridated
More informationHonorary Fellow of the Royal College of Obs. & Gyn. First Indian to receive FIGO s Distinguished Merit Award for Services towards women s health.
Prof.Duru Shah Founder President The PCOS Society (India) President Elect of the Indian Society for Assisted Reproduction (ISAR) Honorary Fellow of the Royal College of Obs. & Gyn. First Indian to receive
More informationTITLE: Crushed Buprenorphine or Buprenorphine-Naloxone for Opioid Dependency: A Review of the Clinical Effectiveness and Guidelines
TITLE: Crushed Buprenorphine or Buprenorphine-Naloxone for Opioid Dependency: A Review of the Clinical Effectiveness and Guidelines DATE: 18 July 2016 CONTEXT AND POLICY ISSUES Opioid dependence is a chronic
More informationIVF: PAST, PRESENT AND FUTURE
IVF: PAST, PRESENT AND FUTURE Mark Larman Chief Scientific Officer 1 HISTORY OF IVF IVF first achieved with rabbits in 1959 IVF with human gametes - pioneered by Robert Edwards and Patrick Steptoe during
More informationTITLE: Chiropractic Interventions for Acute or Chronic Lower Back Pain in Adults: A Review of the Clinical and Cost-Effectiveness
TITLE: Chiropractic Interventions for Acute or Chronic Lower Back Pain in Adults: A Review of the Clinical and Cost-Effectiveness DATE: 10 February 2009 CONTEXT AND POLICY ISSUES: Low back pain (LBP) is
More informationTITLE: Cognitive Behavioural Therapy for Insomnia in Adults: A Review of the Clinical Effectiveness
TITLE: Cognitive Behavioural Therapy for Insomnia in Adults: A Review of the Clinical Effectiveness DATE: 11 May 2010 CONTEXT AND POLICY ISSUES: Insomnia refers to difficulty initiating and/or maintaining
More informationIVM in PCOS patients. Introduction (1) Introduction (2) Michael Grynberg René Frydman
IVM in PCOS patients Michael Grynberg René Frydman Department of Obstetrics and Gynecology A. Beclere Hospital, Clamart, France Maribor, Slovenia, 27-28 February 2009 Introduction (1) IVM could be a major
More informationTITLE: Optimal Oxygen Saturation Range for Adults Suffering from Traumatic Brain Injury: A Review of Patient Benefit, Harms, and Guidelines
TITLE: Optimal Oxygen Saturation Range for Adults Suffering from Traumatic Brain Injury: A Review of Patient Benefit, Harms, and Guidelines DATE: 11 April 2014 CONTEXT AND POLICY ISSUES Traumatic brain
More informationTITLE: Computed Tomography: A Review of the Risk of Cancer Associated with Radiation Exposure
TITLE: Computed Tomography: A Review of the Risk of Cancer Associated with Radiation Exposure DATE: 18 August 2009 CONTEXT AND POLICY ISSUES: Health care professionals order diagnostic imaging for their
More informationAre all-freeze cycles & frozen-thawed embryo transfers improving IVF outcomes?
Are all-freeze cycles & frozen-thawed embryo transfers improving IVF outcomes? Andrea Weghofer Foundation for Reproductive Medicine 2017 New York, November 16-19 Conflict of interest No relevant financial
More informationTITLE: Shilla and MAGEC Systems for Growing Children with Scoliosis: A Review of the Clinical Benefits and Cost-Effectiveness
TITLE: Shilla and MAGEC Systems for Growing Children with Scoliosis: A Review of the Clinical Benefits and Cost-Effectiveness DATE: 17 January 2013 CONTEXT AND POLICY ISSUES Early-onset scoliosis (EOS)
More informationOocyte maturity and preimplantation development in relation to follicle diameter in gonadotropin-releasing hormone agonist or antagonist treatments
IN VITRO FERTILIZATION Oocyte maturity and preimplantation development in relation to follicle diameter in gonadotropin-releasing hormone agonist or antagonist treatments Daniela Nogueira, Ph.D., a Shevach
More informationService Line: Rapid Response Service Version: 1.0 Publication Date: October 30, 2018 Report Length: 7 Pages
CADTH RAPID RESPONSE REPORT: SUMMARY WITH CRITICAL APPRAISAL Topical Silver Nitrate for the Management of Hemostasis: A Review of Clinical Effectiveness, Cost- Effectiveness, and Guidelines Service Line:
More informationOptimize your success
ANDROLOGY BY ORIGIO Optimize your success by selecting the highest quality sperm QUALITY CONTROL OOCYTE RETRIEVAL ANDROLOGY & IUI FERTILIZATION CULTURE PGD & PGS CRYOPRESERVATION EMBRYO TRANSFER The importance
More informationHow effective is egg freezing as a preventative treatment for young women in securing their ability to reproduce later in life?
How effective is egg freezing as a preventative treatment for young women in securing their ability to reproduce later in life? Vitaly A. Kushnir MD Center for Human Reproduction New York City Milestones
More informationIVF (,, ) : (HP-hMG) - (IVF- ET) : GnRH, HP-hMG (HP-hMG )57, (rfsh )140, (Gn)
34 11 Vol.34 No.11 2014 11 Nov. 2014 Reproduction & Contraception doi: 10.7669/j.issn.0253-3X.2014.11.0892 E-mail: randc_journal@163.com IVF ( 710003) : (H-hMG) - (IVF- ET) : GnRH H-hMG (H-hMG ) (rfsh
More informationEgg Freezing for. Your Future. Specialists in Reproductive Medicine & Surgery, P.A.
Egg Freezing for Your Future Specialists in Reproductive Medicine & Surgery, P.A. www.dreamababy.com Egg freezing can be a game changer for women 40 years of age and younger. It has tremendous potential
More informationORIGINAL ARTICLE. Introduction. Farzaneh Fesahat 1,2, Razieh Dehghani Firouzabadi 2, Azita Faramarzi 2, Mohammad Ali Khalili 2
ORIGINAL ARTICLE pissn 2233-8233 eissn 2233-8241 Clin Exp Reprod Med 2017;44(2):79-84 The effects of different types of media on in vitro maturation outcomes of human germinal vesicle oocytes retrieved
More informationTITLE: Abuse and Misuse Potential of Dimenhydrinate: A Review of the Clinical Evidence
TITLE: Abuse and Misuse Potential of Dimenhydrinate: A Review of the Clinical Evidence DATE: 01 December 2015 CONTEXT AND POLICY ISSUES Dimenhydrinate (marketed as Gravol in Canada and Dramamine in the
More informationTITLE: Periodic Dental Examinations for Oral Health: A Review of Clinical Effectiveness, Cost Effectiveness, and Guidelines
TITLE: Periodic Dental Examinations for Oral Health: A Review of Clinical Effectiveness, Cost Effectiveness, and Guidelines DATE: 21 May 2014 CONTEXT AND POLICY ISSUES While there is no accepted universal
More informationClinical aspect of endometrial injury!
Clinical aspect of endometrial injury! Zeev Shoham, M.D. Department of Obstetrics and Gynecology Kaplan Hospital, Rehovot, Israel Implantation Process Good morphology embryo Normal uterus & receptive endometrium
More informationTITLE: Vitamin D Supplementation in the Elderly and Long-Term Care Residents: Clinical Effectiveness and Guidelines for Use
TITLE: Vitamin D Supplementation in the Elderly and Long-Term Care Residents: Clinical Effectiveness and Guidelines for Use DATE: 20 March 2009 RESEARCH QUESTIONS: 1. What is the clinical effectiveness
More informationTITLE: Long-acting Opioids for Chronic Non-cancer Pain: A Review of the Clinical Efficacy and Safety
TITLE: Long-acting Opioids for Chronic Non-cancer Pain: A Review of the Clinical Efficacy and Safety DATE: 27 August 2015 CONTEXT AND POLICY ISSUES Chronic non-cancer pain (CNCP) of neuropathic or proprioceptive
More informationTitle: Non-Steroidal Anti-Inflammatory Drugs for Analgesia in Patients with Fracture: Evidence for Use
Title: Non-Steroidal Anti-Inflammatory Drugs for Analgesia in Patients with Fracture: Evidence for Use Date: 03 June 2008 Context and policy issues: In 2000-2001, 3.4 million Canadians aged 12 years or
More informationHealth Interventions in Ambulatory Cancer Care Centres DRAFT. Objectives. Methods
ENVIRONMENTAL SCAN Health Interventions in Ambulatory Cancer Care Centres Context Cancer, a complex, chronic condition, will affect an estimated two in five Canadians in their lifetime. 1 Cancer requires
More informationAdoption and Foster Care
GLOSSARY Family building via Adoption and Foster Care October 2018 www.familyequality.org/resources A Anonymous Donor: A person who donated sperm or eggs with the intention of never meeting resulting children.
More informationPOSEIDON s stratification of Low prognosis patients in ART and its new proposed marker of successful outcome: The WHY, the WHAT, and the HOW
POSEIDON s stratification of Low prognosis patients in ART and its new proposed marker of successful outcome: The WHY, the WHAT, and the HOW Sandro C. Esteves, MD., PhD. I. The WHY The management of patients
More informationDATE: 21 November 2012 CONTEXT AND POLICY ISSUES
TITLE: Vitamin E Infused Polyethylene Liners, Conventional Polyethylene Liners, and Cross-Linked Polyethylene Liners for Knee Articular Resurfacing in Adults: A Review of Clinical and Cost-Effectiveness
More informationTITLE: Universal, Community-Based Developmental Screening Tools for Children 6 Years and Younger: A Review of Clinical Effectiveness
TITLE: Universal, Community-Based Developmental Screening Tools for Children 6 Years and Younger: A Review of Clinical Effectiveness DATE: 23 September 2009 CONTEXT AND POLICY ISSUES: Universal, community-based
More informationStudy on Several Factors Involved in IVF-ET of Human Beings
Study on Several Factors Involved in IVF-ET of Human Beings Lei X 1, Zhuoran W 1, Bin L 1, Huiming L 1, Hongxiu Z 1, Yajuan Z 1, Yingbo Q 1, Guixue Z 2 1 The First Clinical College of Harbin Medical University,
More informationCONSENT FOR ASSISTED REPRODUCTION In Vitro Fertilization, Intracytoplasmic Sperm Injection, Assisted Hatching, Embryo Freezing and Disposition
CONSENT F ASSISTED REPRODUCTION In Vitro Fertilization, Intracytoplasmic Sperm Injection, Assisted Hatching, Embryo Freezing and Disposition Please read the following consent carefully. If you do not understand
More informationNumber of oocytes and live births in IVF
Number of oocytes and live births in IVF Dr Sesh K Sunkara MD, MRCOG Royal Marsden Hospital, London Kings Healthcare Partners (Guy s & St Thomas NHS Foundation Trust), London, UK Background IVF results
More informationTITLE: Levothyroxine for Solid Organ Donors: A Review of the Clinical-Effectiveness and Guidelines
TITLE: Levothyroxine for Solid Organ Donors: A Review of the Clinical-Effectiveness and Guidelines DATE: 20 May 2009 CONTEXT AND POLICY ISSUES: Organ transplantation is a life-saving treatment for patients
More informationRAH s Regional Fertility & Women s Endocrine Clinic FAQs
RAH s Regional Fertility & Women s Endocrine Clinic FAQs What changes are being made to the Regional Fertility & Women s Endocrine Clinic at the Lois Hole Hospital for Women in the Royal Alexandra Hospital
More informationMedStar Health, Inc. POLICY AND PROCEDURE MANUAL Policy Number: PA.018.MH Last Review Date: 08/04/2016 Effective Date: 01/01/2017
MedStar Health, Inc. POLICY AND PROCEDURE MANUAL PA.018.MH Infertility- Treatment This policy applies to the following lines of business: MedStar Employee (Select) MedStar MA DSNP CSNP (Not Covered) MedStar
More informationTrends in Egg Donation. Vitaly A. Kushnir MD Center for Human Reproduction
Trends in Egg Donation Vitaly A. Kushnir MD Center for Human Reproduction Disclosures No relevant financial relationships to disclose CHR views the commercial trade in human oocytes with considerable ethical
More informationDATE: 10 February 2016 CONTEXT AND POLICY ISSUES
TITLE: Neuromuscular Monitoring for Patients Receiving Continuous Paralytic or Neuromuscular Blocking Agents: A Review of the Clinical Effectiveness and Guidelines DATE: 10 February 2016 CONTEXT AND POLICY
More informationTitle: Positron Emission Tomography (PET) for Staging Cervical Cancer: Clinical Effectiveness and Guidelines for Use
Title: Positron Emission Tomography (PET) for Staging Cervical Cancer: Clinical Effectiveness and Guidelines for Use Date: 16 July 2008 Research question: 1. What is the clinical effectiveness of positron
More informationResults of the Virtual Academy of Genetics (VAoGEN) questionnaire on Mosaicism in PGS
Results of the Virtual Academy of Genetics (VAoGEN) questionnaire on Mosaicism in PGS Ariel Weissman, MD IVF Unit, Dep. Ob/Gyn Wolfson Medical Center, Holon Sackler Faculty of Medicine, Tel Aviv University
More informationEGG FREEZING FOR SOCIAL REASONS. P. Patrizio, M.D., MBE, HCLD Yale University Fertility Center New Haven, CT-USA
EGG FREEZING FOR SOCIAL REASONS P. Patrizio, M.D., MBE, HCLD Yale University Fertility Center New Haven, CT-USA Percentage of married, childless American women who experienced infertility problems for
More informationInfluence ovarian stimulation on oocyte and embryo quality. Prof.Dr. Bart CJM Fauser
Influence ovarian stimulation on oocyte and embryo quality Prof.Dr. Bart CJM Fauser How to balance too much vs too little? Lecture Outline Context ovarian stimulation Impact ovarian stimulation on oocyte
More informationIRB USE ONLY Approval Date: September 10, 2013 Expiration Date: September 10, 2014
Approval : September 10, 2013 Expiration : September 10, 2014 DESCRIPTION: The goal of Assisted Reproductive Technology (ART) is to help infertile couples to become pregnant. During treatment, some cellular
More informationOocyte maturation. A.Trounson 1 ' 3, C.Anderiesz 1, G.MJones 1, A.Kausche 1, N.Lolatgis 2 and C.Wood 2
A.Trounson 1 ' 3, C.Anderiesz 1, G.MJones 1, A.Kausche 1, N.Lolatgis 2 and C.Wood 2 Centre for Early Human Development, Institute of Reproduction and Development, Monash University, Monash Medical Centre,
More information- Meta. : (rfsh); (ufsh); (IVF); : R711.6 : A : X(2015) : hmg( FSH LH) [ufsh, (ufsh-p) (ufsh-hp)] (rfsh) [1] 80, rfsh, 90, :
35 2 Vol.35 No.2 2015 2 Feb. 2015 Reproduction & Contraception doi: 10.7669/j.issn.0253-357X.2015.02.0099 E-mail: randc_journal@163.com (FSH) - Meta FSH ( 400010) : (IVF) (ICSI) (rfsh) (ufsh) (COS) : PubMed
More informationCurrent Evidence On Infertility Treatment
Current Evidence On Infertility Treatment Mahmoud A.M. Abdel-Aleem Regina Kulier WHO/GFMER 2003 Problem of Infertility It is a state in which a couple, desirous of a child, cannot conceive after 12 months
More informationLuteal phase rescue after GnRHa triggering Progesterone and Estradiol
Luteal phase rescue after GnRHa triggering Progesterone and Estradiol L. Engmann University of Connecticut Disclaimer Fertility Speaker Bureau Merck Pharmaceuticals Introduction GnRH agonist is effective
More informationApplication of OMICS technologies on Gamete and Embryo Selection
Application of OMICS technologies on Gamete and Embryo Selection Denny Sakkas, Ph.D. Scientific Director, Boston IVF Waltham, MA, USA THE FUTURE ROLE OF THE EMBRYOLOGIST WILL FOCUS ON PROVIDING OUR PATIENTS
More informationTammie Roy Genea Biomedx Sydney, Australia. Declared to be stakeholder in Genea Biomedx
Tammie Roy Genea Biomedx Sydney, Australia Declared to be stakeholder in Genea Biomedx 1 24-25 September 2015 Madrid and Alicante, Spain Importance of cryopreservation in Assisted Reproductive Technology
More informationTITLE: Hypertonic Saline Nebules for Patients with Cystic Fibrosis and Bronchioectasis: A Review of the Clinical and Cost-Effectiveness
TITLE: Hypertonic Saline Nebules for Patients with Cystic Fibrosis and Bronchioectasis: A Review of the Clinical and Cost-Effectiveness DATE: 16 March 2009 CONTEXT AND POLICY ISSUES: Hypertonic saline
More informationTITLE: Group Therapy for Adults with Axis II Disorders: A Review of Clinical Effectiveness
TITLE: Group Therapy for Adults with Axis II Disorders: A Review of Clinical Effectiveness DATE: 19 November 2009 CONTEXT AND POLICY ISSUES: Axis II disorders include personality disorders and mental retardation.
More informationTITLE: Pain Scales in Acute Care Settings: A Review of the Accuracy and Reliability
TITLE: Pain Scales in Acute Care Settings: A Review of the Accuracy and Reliability DATE: 11 June 2010 CONTEXT AND POLICY ISSUES: Pain measurement is a complex and challenging area of health measurement.
More informationData collected through IVF- Worldwide.com
Data collected through IVF- Worldwide.com Science vs. Clinical Practice Zeev Shoham, MD Director of the Reproductive Medicine and IVF Unit Department Ob/Gyn, Kaplan Medical Center Rehovot, Israel 1 Evidence
More informationExtended embryo culture in human assisted reproduction treatments
Human Reproduction Vol.16, No.5 pp. 902 908, 2001 Extended embryo culture in human assisted reproduction treatments M.T.Langley 1,3, D.M.Marek 1, D.K.Gardner 2, K.M.Doody 1 and K.J.Doody 1 1 Center for
More informationInterpreting follicular Progesterone: Late follicular Progesterone to Estradiol ratio is not influenced by protocols or gonadotropins used
Interpreting follicular Progesterone: Late follicular Progesterone to Estradiol ratio is not influenced by protocols or gonadotropins used Ellenbogen A., M.D., Shalom-Paz E., M.D, Asalih N., M.D, Samara
More informationCADTH Therapeutic Review
Canadian Agency for Drugs and Technologies in Health Agence canadienne des médicaments et des technologies de la santé CADTH Therapeutic Review August 2012 Volume 1, Issue 1A Antithrombotic Therapy for
More informationCommissioning Policy For In Vitro Fertilisation (IVF) / Intracytoplasmic Sperm Injection (ICSI) within Tertiary Infertility Services
Commissioning Policy For In Vitro Fertilisation (IVF) / Intracytoplasmic Sperm Injection (ICSI) within Tertiary Infertility Services Reference No: Version: 2 Ratified by: EMSCGP006V2 EMSCG Date ratified:
More informationM Magdy EL-Sheikh FRCOG London, FRCS Glasgow Director ART unit Dr Soliman Fakeeh hospital Jeddah Saudi Arabia
M Magdy EL-Sheikh FRCOG London, FRCS Glasgow Director ART unit Dr Soliman Fakeeh hospital Jeddah Saudi Arabia The versatile nature reproduction Reproduction as a sign of life Reproduction as a sign of
More informationDATE: 22 May 2013 CONTEXT AND POLICY ISSUES
TITLE: Intraperitoneal versus Intravenous Chemotherapy for the Treatment of Ovarian Cancer: A Review of the Comparative Clinical Evidence, Safety, Cost- Effectiveness, and Guidelines DATE: 22 May 2013
More informationICSI Cycle with a Sperm from TESE versus From Ejaculate in Oligospermic Men
ICSI Cycle with a Sperm from TESE versus From Ejaculate in Oligospermic Men Hassan S.O. Abduljabbar Ohoud Al-Shamrani Osama Bajouh King Abdulaziz University, P.O.Box 8215 Jeddah 21452, Kingdom of Saudi
More informationTITLE: Early Identification of Sepsis: A Review of the Evidence for Clinical Indicators and Guidelines for Management
TITLE: Early Identification of Sepsis: A Review of the Evidence for Clinical Indicators and Guidelines for Management DATE: 01 June 2010 CONTEXT AND POLICY ISSUES: Sepsis syndrome covers a broad array
More informationWe are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,500 108,000 1.7 M Open access books available International authors and editors Downloads Our
More informationDay 4 embryo selection is equal to Day 5 using a new embryo scoring system validated in single embryo transfers
Human Reproduction Vol.23, No.7 pp. 1505 1510, 2008 Advance Access publication on February 21, 2008 doi:10.1093/humrep/dem419 Day 4 embryo selection is equal to Day 5 using a new embryo scoring system
More information1. What is the comparative efficacy of IV lorazepam and IV diazepam for the treatment of febrile seizures in children (less than 12 years of age)?
Title: The Use of Lorazepam for Febrile Seizures in Children Date: 25 January 2008 Context and policy issues: Febrile seizures are the most common form of childhood seizures, affecting approximately 2
More informationShould we advise patients undergoing IVF to start a cycle leading to a day 3 or a day 5 transfer?
Human Reproduction Vol.19, No.11 pp. 2550 2554, 2004 Advance Access publication August 6, 2004 doi:10.1093/humrep/deh447 Should we advise patients undergoing IVF to start a cycle leading to a day 3 or
More informationRecording and measuring the outcome of an ART cycle
Recording and measuring the outcome of an ART cycle Australian and New Zealand Reproduction Database (ANZARD) Dr Katie Harris Biostatistician National Perinatal Epidemiology and Statistics Unit (NPESU)
More information