VM 744 THERIOGENOLOGY Spring 2013

Transcription

1 VM 744 THERIOGENOLOGY Spring 2013 Credits-3 Coordinator: Patrick M., DVM, PhD, Diplomate ACT Department of Clinical Sciences Office: Equine Reproduction Laboratory Phone: Goal: To provide an overview of reproductive function and disease in domestic animals. Instructors: Dr. Dick Biomedical Sciences Dr. Greg Burns Private Practice Dr. Page Dinsmore Clinical Sciences Dr. Ryan Ferris Clinical Sciences Dr. Frank Garry Clinical Sciences Dr. Jim Biomedical Sciences Dr. Patrick Clinical Sciences Dr. Richard Wheeler Clinical Sciences/Private Practice T.A.: Paula Moffett Lectures: Wed. and Fri. 2:10-3:00 (101 Pathology) Laboratory: Tues. 8-10, or 12-2 (Anat 117 for Gross Labs, Path 112 for Microscopy labs, other locations will be used as indicated on schedule) Textbooks: Exams: None required. The following books are recommended and are on reserve: 1. Current Therapy in Large Animal Theriogenology 2 (2007) Youngquist and Threlfall. 2. Current Therapy in Equine Reproduction (2007) Samper, Pycock and McKinnon 3. Manual of Small Animal Reproduction and Neonatology (1998) Simpson 4. Canine and Feline Theriogenology (2001) Johnston et al. 5. Canine and Feline Endocrinology and Reproduction (2004) Feldman and Nelson There are 2 midterms and one final exam (not comprehensive) - Tentative schedule: Exam # 1 (Feb 19): lectures 1-8 and labs 1-4 Exam # 2 (April 2): lectures 9-18 and labs 5-8 Exam # 3 (May ; TBA): lectures and labs 9-13 (not comprehensive) The format for the midterms will be multiple choice, short answer and identification questions. Grades: Each examination is worth approximately one-third of your grade. Passing Grade: 70 %

2 THERIOGENOLOGY VM744 Spring 2013 Lectures 2:00-2:50 (Wednesday and Friday) in Pathology 101 Laboratory 8-10, and 12-2 (Tuesday); location variable Date Instr Lecture topic Laboratory topic Jan Course overview Jan 23 Jan Development of the Reproductive Tract - Chromosomal sex - Embryonic origin of reproductive tissues - Factors responsible for phenotype 2. Reproductive Physiology of the Male - Anatomy of the male reproductive tract - Hypothalamus - Pituitary - Testis - Production sites and target cells - Feedback mechanisms Jan Gross anatomy: male - Testis, tubular system and accessory sex glands - Scrotum and external genitalia Jan 30 Feb 1 3. Regulation of testicular function - Hormones - Seasonality - Thermoregulation 4. Spermatogenesis Feb 5 3. Microanatomy: male - Testis, tubular system and accessory sex glands - Leydig and Sertoli cells - Blood-Testis barrier 5. Characteristics of Semen

3 Feb 6 - Sperm structure - Maturation and longevity - Storage sites - Seminal plasma Feb 8 6. Semen Collection and Analysis - Techniques of collection - Motility analysis (visual and CASA) - Morphology stains - Concentration measurements - Flow cytometry Feb Semen Evaluation - dog semen collection Feb 13 Feb Breeding Soundness Evaluation of the Male 8. Reproductive Pathology of the Male - Prostatic disease - Pathophysiology of spermatogenesis - Cryptorchidism - Hypogonadism - Orchitis -Tumors Feb 19 EXAMINATION # 1 Feb 20 Feb Reproductive Endocrinology of the Female - Hypothalamic hormones - Pituitary hormones - Ovarian hormones - Feedback mechanisms 10. Reproductive Cycles, Ovarian Function and Sexual Behavior - Follicle development - Ovulation - Corpus luteum formation - Luteolysis - Sexual Dimorphism - Hormones and Behavior - Pheromones 5. Gross Anatomy: Female

4 Feb 26 - Gross tracts from cow, mare, bitch, etc. Feb 27 Mar Factors Affecting Reproduction - Puberty - Seasonality/photoperiod - Reproductive senescence - Postpartum anestrus - Nutrition 12. The Estrous Cycle: Large Animal - Cattle - Small ruminants - Horses - Llamas - Pigs Mar 5 6. Microscopic Anatomy: Female - Microscopy of ovaries, oviduct, uterus, etc. of domestic animals Mar 6 Mar 8 Wheeler Wheeler 13. Small Animal Reproduction - Estrous cycle of dogs and cats 14. Canine Reproduction - Breeding management principles Mar 12 / Wheeler 7. Canine Breeding Management Lab - Vaginal cytology - Endocrine Diagnostic tests - Breeding techniques Mar 13 Mar Contraception 16. Monitoring Reproductive Function in the Non-pregnant female - Diagnostic endocrinology - Estrus detection - Ultrasonography - Palpation - Radiography - Culture, cytology and biopsy

5 Mar SPRING BREAK Mar Equine: Diagnostics Lab - Teasing - Ultrasonography - Cytology - Speculum Examination (location: ERL) Mar 27 Mar 29 Ferris 17. Manipulation of Reproductive Function in the Non-pregnant female - Estrous synchronization - Induction of folliculogenesis - Induction of ovulation -Termination of luteal activity - Superovulation - Suppression of ovarian activity 18. Female Reproductive Pathology - Developmental anomalies - Acquired anomalies Apr 2 EXAMINATION # 2 (LOCATION:PATH 112) Apr 3 Apr Physiology of Pregnancy I - gamete transport - fertilization - Preimplantation embryology and technology - Maternal recognition of pregnancy - Twinning, hybrids 20. Physiology of Pregnancy II - Placentation and placental function - Maternal physiology during pregnancy - Principals of pregnancy diagnosis - Fates of the abnormal conceptus Apr 9 9. Pregnancy Diagnosis: Apr Principles of Developmental Pathology - Incidence and significance - Causes of developmental disease - Factors involved in pathogenesis:

6 Apr 12 Critical periods, thresholds 22. Teratology: Illustrative Examples Apr Placental Structure Apr 17 Apr Parturition - Preparation for parturition - Initiation of parturition - Stages of labor - Induction of labor 24. Obstetrics/Dystocia - Normal delivery - Causes of dystocia - Obstetrical intervention and postpartum care Apr Obstetrics I: Principles of Large Animal Obstetrics (location: Path 112) Apr 24 Apr 26 Burns Burns 25. Small Animal Obstetrics - I 26. Small Animal Obstetrics - II Apr Obstetrics II: Advanced Procedures in Large Animal Obstetrics (location: VTH Food Animal Lab) May 1 May 3 Garry 27. Assisted Reproduction Techniques - Embryo Transfer (ET) - Gamete Intrafallopian Transfer (GIFT) - Sexing sperm - Intracytoplasmic Sperm Injection (ICSI) - InVitro Fertilization (IVF) 28. Neonatology May 7 Dinsmore 13. Mammary Gland

7 May 8 May 10 Dinsmore Dinsmore 29. Mammary Gland - Development - Anatomy - Physiology 29b. Breeding Management of Cattle - Comments on Heat detection, artificial insemination 30. Lactation - Endocrine control - Colostrum - Lactation cycle - Regression and involution - Mastitis May Revised: 10/23/2012 PMc FINAL EXAMINATION Time: TBA (location: Path 101)