Gross appearance of nodular hyperplasia in material obtained from suprapubic prostatectomy. Note the multinodular appearance and the admixture of

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4 Gross appearance of nodular hyperplasia in material obtained from suprapubic prostatectomy. Note the multinodular appearance and the admixture of solid and microcystic areas.

5 Whole mount of nodular hyperplasia of prostate, showing nodular configuration and cystic changes.

6 Nodular hyperplasia of prostate, with cystic dilatation of the glands. Characteristically, the epithelium is tall on one side and flattened on the other.

7 Gross appearance of infarct of prostate. The lesion has a bright red color and bulges on the cut surface. Nodular hyperplasia is also present.

8 Prominent metaplastic changes at the edge of a prostatic infarct. These are sometimes overdiagnosed as carcinoma.

9 Granulomatous prostatitis.. The inflammatory infiltrate, which contains scattered multinucleated cells, is characteristically centered on a prostatic acinus.

10 Low-power appearance of a postoperative spindle cell nodule. The surface is ulcerated and covered by granulation tissue.

11 Postoperative spindle cell nodule. The lesion is hypercellular,, relatively monomorphic,, and accompanied by high mitotic activity.

12 Immunoreactivity for low-molecular molecular-weight keratin (Cam 5.2) in the proliferating cells of a postoperative spindle cell nodule. This finding should not lead to a diagnosis of sarcomatoid carcinoma.

13 Urethral polyp composed of well-differentiated prostatic glands. This is a common cause of hematuria in young males.

14 Whole mount of radical prostatectomy specimen showing involvement by an extremely small prostatic carcinoma located at the periphery of the organ and accompanied by perineurial invasion, the latter better seen in the inset.

15 Gross appearance of prostatic adenocarcinoma.. The tumor appears as an irregularly shaped, yellowish mass with punctate foci of necrosis in a gland that is also involved by nodular hyperplasia.

16 Microscopic appearance of prostatic carcinoma. Well- differentiated tumor composed of medium-sized glands. Note the irregular shape of the glands and presence of intraluminal basophilic secretion. The contrast with the non-neoplastic neoplastic glands present in the field is obvious.

17 Poorly differentiated tumor growing in a diffuse fashion. The appearance is reminiscent of that of invasive lobular carcinoma of breast.

18 Well-differentiated prostatic adenocarcinoma showing intraluminal crystalloids.

19 Whole mount of large duct adenocarcinoma.. The tumor is centrally located and has a distinctly papillary configuration.

20 Large duct adenocarcinoma of prostate with papillary features.

21 Primary transitional cell carcinoma of prostate involving large suburethral prostatic ducts. The bladder was not affected.

22 Adenocarcinoma of prostate combining features of acinar and large duct type.

23 Lack of basal cells around the neoplastic acini,, as evidenced by immunostaining for high-molecular molecular-weight keratin. The few residual non-neoplastic neoplastic glands provide an internal control.

24 Focal neuroendocrine differentiation in prostatic adenocarcinoma,, as demonstrated with immunostaining for chromogranin.

25 Some of the neuroendocrine cells present in this prostatic adenocarcinoma show cytoplasmic coarse granules resembling those of intestinal Paneth cells.

26 Mucinous adenocarcinoma of prostate. Most of the mucin is located extracellularly.

27 So-called adenoid basal cell tumor of prostate. The central tumor nest shows an appearance reminiscent of that seen in adenoid cystic carcinoma of salivary glands.

28 Low-grade prostatic intraepithelial neoplasia (PIN I).

29 High-grade grade prostatic intraepithelial neoplasia (PIN III).

30 Atypical adenomatous hyperplasia (adenosis( adenosis) ) of prostate.

31 Radiation changes in prostate. The acini show marked nuclear pleomorphism.. On low power, the lobular architecture was retained.

32 Basal cell hyperplasia of prostate. The low-power architecture is characteristic of this benign process.

33 Clear cell hyperplasia of prostate with a focally cribriform pattern of growth. This lesion is of controversial nature.

34 Sclerosing adenosis of prostate. The features are similar to those of its better-known mammary counterpart.

35 Seminal vesicle epithelium present in a prostatic needle biopsy. The highly complex architecture may induce an overdiagnosis of carcinoma. Note the abundant intracytoplasmic pigment.

36 Prostatic adenocarcinoma initially presenting as left supraclavicular adenopathy.

37 Prostatic adenocarcinoma,, Gleason s s = 6/10.

38 Prostatic adenocarcinoma,, Gleason s s = 7/10.

39 Prostatic adenocarcinoma.. Gleason s s = 8/10. The tumor has a cribriform pattern of growth.

40 Prostatic adenocarcinoma,, Gleason s s = 8/10. This appearance is sometimes referred to as hypernephroid.

41 Prostatic adenocarcinoma,, Gleason s s = 10/10.

42 Prominent cytoplasmic vacuolation in prostatic carcinoma as a result of hormonal treatment. The vacuolization is also present in the area of perineurial invasion.

43 Outer aspect and cut surface of embryonal rhabdomyosarcoma of prostate in a child.

44 Outer aspect and cut surface of embryonal rhabdomyosarcoma of prostate in a child.

45 Prostatic stromal proliferation of uncertain malignant potential (PSUMP).

46 Stromal sarcoma of prostate.

47 Stromal sarcoma of prostate with an appearance reminiscent of phyllodes tumor of breast.

48 Angiosarcoma with epithelioid features involving the prostate. Note the cytoplasmic vacuolization. The diagnosis was confirmed immunohistochemically.

49 Infiltration of the prostatic stroma by the cells of chronic lymphocytic leukemia. This was an incidental finding in an operation done for nodular hyperplasia.