Jan Farrell Nurse Consultant Urological Services Department of Urology Rotherham General Hospital NHS FT

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1 Jan Farrell Nurse Consultant Urological Services Department of Urology Rotherham General Hospital NHS FT

2 Aims of session To promote discussion / interaction Opportunity to discuss with peers Promote learning / share experience Reflect on current practice Question an expert Pharmokinetics not discussed

3 What are men looking for in ED Treatments Men consider the following to be important dimensions of successful treatment:- Cure Pleasure Partner satisfaction Reproduction Naturalness Control Duration Spontaniety Hanson-Divers C et al 1998 Journal of Urology 159:

4

5 Sexual Health is the integration of the somatic, emotional, intellectual and social aspects of sexual being, in ways that are positively enriching and that enhance personality, communication and love (W.H.O.1975)

6 2 Years

7 Treatment - where to begin? What is the problem and what bothers them? Patient s definition clarify Partner s perception Patient Goals Previous treatments? Situational?

8

9 WHAT DO MEN WANT?

10 UKCLS00659 July 2010 Smooth Muscle Contraction Flaccid Smooth Muscle Relaxation Erection

11 Patients who can be prescribed treatment for erectile dysfunction on the NHS (all medications and vacuum devices) Prostate cancer Prostatectomy Multiple sclerosis Polio Severe pelvic injury Single gene neurological disease Spinal cord injury Diabetes Renal failure treated by dialysis or treatment Spina bifida Parkinson s disease Radical pelvic surgery + all other men with severe distress - exceptional circumstances (after specialist assessment) + all patients on treatment from GPs on 14th Sep 98

12 First-time success in ED therapy matters When, according to the patient, treatment did not work, the distress was severe and for many confirmed their lack of self worth. There was an assumption they had to take only one pill for all to be well. When this did not happen, hopes fell 1 When a treatment does not work first time, 77% of men worry that their ED might be permanent 2 1.Tomlinson J, Wright D, BMJ 2004;328: Data on File, Bayer Schering Pharma August 2007

13 Oral medication for the treatment of erectile dysfunction

14

15 Optimising success/managing PDE5i failures Patient Education Sexual stimulation is needed Absorption affected by food (drugs vary) Post-dose timing (drugs vary)

16 Optimising success/managing PDE5i failures Several attempts may be required for optimum effect Dose optimisation Consider an alternative PDE5i if first drug is unsatisfactory

17 (Viagara is now off-licensebayer) Newer Developments New generation Viagra Cialis Tadalafil prn or daily dosing (Lilly) Levitra Vardanafil oral or oro-dispersable (Bayer) Viagra - now off license, prescribe Sildenafil beware only 80% active ingredient

18 Oro Dispersible Preparation

19 Optimising success / managing failures Patient education is paramount PDE5 inhibitor failure may be a lack of education

20

21 PDE 5I (Viagra, Levitra, Cialis) Advantages Ease of use Few side-effects Acceptance by partner OAD forget the ED problem Disadvantages Unable to use for patients on nitrates Delayed response / pre planning Ineffectiveness / interaction with food Side-effects: uncommon Cost

22 Intraurethral (IU) therapy - alprostadil MUSE (Medicated Urethral System for Erection) Pellet of alprostadil inside the urethra Applicator for intraurethral delivery of alprostadil. Depressing the end releases the pellet into the urethra.

23 Transurethral application of alprostadil - MUSE From Padma-Nathan H. New Engl J Med 1997; 338: 1-7

24

25 Advantages of MUSE therapy Speed and ease of use Comfort of application Acceptance by partners

26 Disadvantages of MUSE therapy Penile ache or pain - approx 30% of patients experience this Need to void prior to insertion Need to keep very cool - ideally in fridge Variable response Exercise / warmth Cannot use if possibility of pregnancy

27

28

29 Intracavernosal Injection e.g. alprostadil Cross-section of the shaft of the penis Drug injected directly into the corpus away from midline Midline Corpus cavernosum

30

31 Main advantages of injection therapy Natural looking and feeling erection Ease of use once practiced Natural erections can improve and recover with use

32 Main disadvantages of injection therapy Needle phobia Pain and burning at site Anatomical problems Bruising and swelling of penis Ineffectiveness Difficulties with technique Partnership problems Unpredictability

33 Vacuum Therapy

34 Vacuum Erection Devices

35

36 ErecAid System By Timm Medical Technologies, Inc.

37 Create Negative Pressure to Achieve Engorgement ErecAid System By Timm Medical Technologies, Inc.

38 Apply Pressure- Point Tension Ring to Maintain Rigidity* ErecAid System By Timm Medical Technologies, Inc.

39 Remove Tension Ring; Penis Returns to Flaccid State ErecAid System By Timm Medical Technologies, Inc.

40 Disadvantages.

41 Acceptability of devices Advantages It works! Puts man back in charge of his erections Leads to improvement in natural erections very often Use as a love aid partner participation

42 VTD - Disadvantages Mechanical device - integrate Penis can change colour Penis can be flexible Penis can feel cold Painful Initial cost Unable to sustain the erection. Noisy battery operated Blockage of ejaculate

43 Inflatable Penile Prosthesis

44

45 Penile prosthesis Reservoir Multi- part inflatable prosthesis Cylinders Pump

46 Penile prosthesis implantation Advantages Useful when other treatment options have failed or are contra-indicated High success rate Provides a one-off solution Higher incidence of morbidity and complications than with medical treatment Possible mechanical malfunction of the prosthesis Erosion Disadvantages May require replacement Possible infection Soft Glands High cost / training / annual review Patient and partner acceptance

47 The Future Combination Therapies;- off licence, usually initiated in Specialist services. Launch of Alprostadil topical cream (VITAROS ) in UK - June 2014, apply to tip of penis at site of meatus.

48 The Importance of Patient Preference in the Treatment of ED No one else can insist or decide on a treatment on behalf of the patient, nor ultimately interpret success. In this regard, ED differs from almost all other medical diseases and it s implications are far reaching Heaton JPW et al. European Urology supplements 2002.

49 Thanks for your attention! Any Questions?

Jan Farrell. Nurse Consultant Urology Department of Urology Rotherham General Hospital NHS FT

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