FAILURE IS NOT AN OPTION HOPE IS NOT A PLAN

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2 FAILURE IS NOT AN OPTION HOPE IS NOT A PLAN Doctors' Secrets What Men Want - Testosterone - Sharing the Secrets of Men s Health Donald M. McLeod M.D. and Philip A White M.D. CONTENTS SECTION I Introduction 13 TESTOSTERONE 15 Testosterone in Animals 16 Domestic Animals 17 Evolutionary and Inheritance 18 Early Testosterone Research 20 Expanded Scope 24 The 80s and The 90s 26 The Y Chromosome 28 TESTOSTERONE IN HISTORY 29 Selfish Genes 29 Different Strategies 30 Beyond The Cave 33 Empires and Dynasties 34 The Fall 37 Over The Centuries 37 Courage 41 Moral Courage 42 The Individual 44 Closing Quotes 46 MORE SEX FOR MEN AND WOMEN 47 The Importance of Sex 47 The Two Keys 48 Male Sexuality 48 What s The Truth About Male Sexuality 50 Normal Female Sexual Responses 55 RENEWING YOUR LOVE LIFE 56 Arousing Your Partner 56 How To Improve Sexual Arousal 57 Dealing With Your Sexual Inhibitions 59 Improving Inhibited Ejaculation 60 Improving Early Ejaculation 61 Sex Therapies 63 The Truth About Testosterone for Sports, Stress, and Sexual Health

3 SECTION II The Physical WHAT MAKES A MAN? 65 Anatomy and Function of the Testicles 66 Infertility and Sperm Cells 68 Disorders of Androgen Production 69 Hypogonadism or Deficiency 70 Testicular Syndromes 71 Variations in Penis Size 72 What Does an International Penis Look Like? 73 Health in General 74 Smoking 75 Fat 76 Diet 77 Exercise 79 Stress 81 Alcohol 82 Hormonal Measures 83 (E.D.) Cialis, Viagra and Levitra 85 Erectile Dysfunction (Viagra to Cialis) 86 More Drastic Measures 90 THE MENTAL, THE SPIRITUAL, THE RELATIONSHIP Love 92 Cycles 92 The Nefarious Selfish Gene 93 Life Span 97 Vive La Difference 98 Free To Choose 99 Choices 100 The Rudder and The Keel 102 The Love You Make 103 The Sexual Affair 104 Fall In Love With Anyone? 106 THE FUTURE OF TESTOSTERONE 109 Be Not The First, Nor The Last 110 First Things First 111 Reasons 111 Wider Applications 113 Newer Applications 115 Diagnostics 116 Testing 118 Improvements 120 The Alpha and Omega 122 Summation 124 Doctors' Secrets Page 2 of 7

4 SECTION III Testosterone And Your Health Depression 127 Alzheimer s 129 The Human Brain 129 Mood, Emotion, and Memory 130 The Old, Aging Brain 131 Nutrition and The Brain Diet 134 Brain Nutrients As Brain Boosters 136 Improving Your Brain (IQ Boosters) 137 The Heart of the Matter 138 Killing Me Softly 139 A Living Killer 139 Gut Fat, Butt Fat 141 Sex Hormones and Fat Distribution 141 Differences 142 Muscle and Bone 144 Testosterone To Prevent Bone Loss 146 Cardiovascular Disease and Testosterone 151 Testosterone and Heart Disease 153 Risk Factors With Low Testosterone 159 Treatment For Cardiovascular Risk Factors 160 A Finger To Heart Disease 161 Other Dancers in the Dance 161 The Blind Men and The Elephant 163 Low Testosterone, High Risk 164 Specific Studies 167 The Testosterone Rescue 168 Watch Out For Changes in Testosterone Production (drugs and diseases) 170 Treatment For Deficiency 171 What If You Take Testosterone Treatments? 180 OTHER IMPORTANT HORMONES 182 Cortisone 182 Thyroid 183 Womens Hormones 189 Estrogen in Women 190 Too Much Estrogen For Women 192 Estrogen Replacement For Women 195 Progesterone For Women 196 Progesterone Replacement For Women 197 Replacement Methods For Women 197 Testosterone For Women 198 Estrogen in the Aging Male 199 Doctors' Secrets Page 3 of 7

5 DHEA 201 Somapause: Growth Hormone 205 Growth Hormone and Testosterone 208 Andropause: What is it? 210 Andropause and Diagnosis 212 Why Does Testosterone Decline As We Age? 214 SECTION IV Athletic Performance And Steroids Going For The Gold 219 The Edge 220 Roids, Juice, Rocket Fuel 222 Huge Distinction 223 The Problems 226 Side Effects 228 Adolescents 229 Roid Rage 230 Cautionary Note 231 TESTOSTERONE IN SPORTS AND BODYBUILDING Steroids In Sports 231 Performance Enhancing Creatine 235 Steroid Summary 236 Steroid Abuse 241 Sports Steroids and the Liver 243 Steroids and Drug Testing 247 Steroid s Future 248 SECTION V Diet, Supplements, Drugs And Lifestyle For The Perfect Prostate INCIDENCE OF PROSTATE CANCER 251 Diet (fruit, vegetables, fiber, soy protein, fats, calories, sugars) 253 Lifestyle (stress, habits, exercise, toxins) 259 Vitamins, Minerals, Herbs and Nutritional Supplements 261 Hormones and Medications 268 Immune System Support 271 CONDITIONS OF THE PROSTATE 272 Prostatitis 272 Benign Prostatic Hypertrophy (BPH) 274 Doctors' Secrets Page 4 of 7

6 SECTION VI Prostate Cancer 277 PREVENTION 278 Early Detection 279 Prostate Specific Antigen (PSA) 280 Semen Testing 281 Digital Rectal Exam (DRE) 282 Transrectal Prostate Ultrasound (TRUS) 282 Prostate Biopsy and Gleason Score 282 Staging 283 Tumor Staging For Positive Biopsies 283 Clinical Staging: 284 Blood Tests and TNM 285 PSA, PAP, NSE, CEA, CGA 285 Prolactin, DHT, Testosterone 286 SHBG, CBC, LFT, LH, CD4 286 Gene Testing 287 Adrenal Androgen Precursors 287 DHEA-s 287 Pictures or Imaging 288 Bone Scan 288 CAT Scan 288 MRI 288 ProstaScint Scan 289 ThUS 289 Pathological Staging Under The Microscope 290 TREATMENT OF PROSTATE CANCER 291 Organ Confined Prostate Cancer Watchful Waiting (WW I) 292 Surgery 293 Procedures 294 Hospital Stay 294 Positives 294 Negatives 295 Radiation Therapy 298 Positives 299 Negatives 299 Brachytherapy 300 Positives 301 Negatives 301 Cryotherapy 301 Doctors' Secrets Page 5 of 7

7 Hormone Therapy For Prostate Cancer 302 Testosterone Deprivation As Therapy For Prostate Cancer 302 Castration 302 Preventing Androgen Production 304 Blocking LHRH Receptors 304 LHRH Agomsts 304 Anti-androgens Alpha Reductase Inhibitors (Finasterides) 306 Combination Therapy 307 Watching Treatment Results 308 Protein Phosphorylation (Aspirin and Anti-inflammatories) 309 Natural Treatments For Prostate Cancer 311 Melatonin 311 Milk Thistle 312 Lycopene 312 PC-SPES? 312 Green Tea 313 Quercetin 313 Indole-3-carbinol 314 Intermittent Hormone Therapy 315 Iatrogenic Andropause 316 Locally Advanced Prostate Cancer 316 Treatment For Recurrent Prostate Cancer 317 PSA Rising Again 317 Metastatic Prostate Cancer 319 Chemotherapy 319 Complementary Treatments 320 Prevention 321 Doctors' Secrets Page 6 of 7

8 SECTION VII Exciting Research 323 Sleep Cycles 323 Stages Of Sleep 326 Sleep Problems 327 TESTOSTERONE AND HAIR LOSS 331 PHEROMONES 339 OLDEST MAN FILE 341 References & Bibliography 343 Index 362 Epilogue 374 About the Authors Dr. Donald M. McLeod, a Canadian medical graduate with 25 years of clinical practice is an international lecturer and author and has a special interest in male gender medicine. Dr. Philip A White, a UK medical graduate, has been in clinical practice for more than 30 years, with a special interest in male gender medicine, is also an author and lecturer. ISBN pages CAD Doctors' Secrets Page 7 of 7