Citation for published version (APA): Lutke Holzik, M. F. (2007). Genetic predisposition to testicular cancer s.n.

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1 University of Groningen Genetic predisposition to testicular cancer Lutke Holzik, Martijn Frederik IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2007 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Lutke Holzik, M. F. (2007). Genetic predisposition to testicular cancer s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

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3 RIJKSUNIVERSITEIT GRONINGEN Genetic Predisposition to Testicular Cancer Proefschrift CIP-gegevens Koninklijke Bilbiotheek, Den Haag Lutke Holzik, M.F. Genetic predisposition to testicular cancer ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op maandag 1 oktober 2007 om 16:15 uur Proefschrift Groningen. Met lit. opg. Met samenvatting in het Nederlands. Verschijningsvorm: Digitaal ISBN: door Martijn Frederik Lutke Holzik Copyright 2007 M.F. Lutke Holzik All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording or otherwise without the written permission of the author. geboren op 25 februari 1974 te Enschede Cover and lay-out: Annemiek van der Kleijn Printed by: Gildeprint, Enschede

4 Promotores Prof. dr. H.J. Hoekstra Prof. dr. D.Th. Sleijfer Paranimfen Stephan Lutke Holzik Deepu Daryanani Copromotores Dr. R.H. Sijmons Dr. J.E.H.M. Hoekstra-Weebers Beoordelingscommissie Prof. dr. S. Horenblas Prof. dr. J.W. Oosterhuis Prof. dr. P.H.B. Willemse All studies in this thesis were designed and carried out at the department of Surgical Oncology, in cooperation with the departments of -Medical Oncology, -Genetics, -Medical Biology, -Pathology and Wenckebach Institute, University Medical Center Groningen, the Netherlands and the Comprehensive Cancer Center North-Netherlands, Groningen, the Netherlands, the department of Clinical Genetics, University of Antwerp, Belgium and the department of Surgery, Medisch Spectrum Twente, Enschede, the Netherlands. This research was financially supported by the Dutch Cancer Society (Koningin Wilhelmina Fonds) grant RUG: and RUG and de Jan Kornelis de Cock foundation. Financial support for the publication of this thesis kindly provided by: Medisch Spectrum Twente, Stichting Werkgroep Interne Oncologie, Integraal Kankercentrum Noord-Nederland, KWF kankerbestrijding, Novartis, GlaxoSmithKline, Sanofi-Aventis, Roche, Astra Zeneca, KCI Medical, Bioprof, Janssen-Cilag, Amgen, Tyco Healthcare, Stryker, Laprolan, Johnson & Johnson Medical, Ethicon Endo-Surgery, Nycomed, Promega, Graduate School GUIDE and MSD.

5 Aan mijn ouders, Voor Marjolijn en Louise.

6 Contents Chapter 1 General introduction, aim and outline of the thesis...11 Chapter 2 Genetic predisposition to testicular germ-cell tumours...23 Lancet Oncololgy. 2004; 5: Chapter 3 Syndromic aspects of testicular carcinoma...43 Cancer. 2003; 97: Chapter 4 Do the eastern and northern parts of The Netherlands differ in testicular cancer?...57 Urology. 2001; 58:636-7(letter) Chapter 5 Testicular carcinoma and HLA Class II genes...61 Cancer. 2002; 95: Chapter 6 Absence of constitutional Y chromosome AZF deletions in patients with testicular germ cell tumors...75 Urology. 2005; 65: Chapter 7 Re-analysis of the Xq27-Xq28 region suggests a weak association of an X-linked gene with sporadic testicular germ cell tumour without cryptorchidism...85 European Journal of Cancer. 2006; 42: Chapter 8 Interest in and motivations regarding genetic testing for testicular germ cell tumour susceptibility...97 Submitted Chapter 9 Summary, discussion and future perspectives Chapter 10 Nederlandse samenvatting, conclusies en toekomstperspectieven Reference list Addendum Dankwoord List of publications Curriculum Vitae...175

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