Tissue-based Immunohistochemical Biomarker Expression in Malignant Glandular Lesions of the Uterine Cervix: a Systematic Review

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Tissue-based Immunohistochemical Biomarker Expression in Malignant Glandular Lesions of the Uterine Cervix: a Systematic Review"

Transcription

1 Tissue-based Immunohistochemical Biomarker Expression in Malignant Glandular Lesions of the Uterine Cervix: a Systematic Review Sandra Lee MD, FRCPC 1 *, Vikrant V. Sahasrabuddhe, MBBS, DrPH 2 *, Diana Mendoza-Cervantes, BS 2, M. Sarah Rose, PhD 3, Rachel Zhao, B Eng, MLIS 4, and Máire A. Duggan MD, FRCPC 1 *co-first authors Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada 2 Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA 3 Research Facilitation and 4 Knowledge Management Department, Alberta Health Services, Calgary, Alberta, Canada

2 Disclosures No financial relationships or conflict of interest to disclose

3 Malignant glandular histotypes of the cervix: 19 primary histotypes per WHO 2014 HPV DNA positive Adenocarcinoma in situ (AIS) Mucinous adenocarcinoma Endometrioid adenocarcinoma Adenosquamous carcinoma HPV DNA negative Atypical lobular endocervical glandular hyperplasia (LEGH) Minimal deviation and gastric type adenocarcinomas (MDA/GAS) Mesonephric carcinoma Serous and clear cell carcinomas

4 Immunohistochemical testing Numerous diagnostic biomarkers available: accuracy uncertain p16 overexpression as a surrogate marker of HPV DNA is a sensitive and specific biomarker in distinguishing HPV positive malignant glandular lesions from normal glandular epithelium and benign lesions of the cervix* Whether IHC expression can discriminate between the different glandular histotypes has not been systematically analysed *Lee S et al. Tissue based immunohistochemical biomarker accuracy in the diagnosis of malignant glandular lesions of the uterine cervix : a systematic review of the literature and meta-analysis. Int J Gynecol Pathol 2016; Oct 31 (epub).

5 Study goal Systematically review literature reporting immunohistochemicallydetected tissue-based biomarker expression amongst glandular histotypes in order to identify differences in biomarker positivity that could have diagnostic utility

6 PICOT framework Population: AIS, MDA/GAS and *invasive adenocarcinomas Index test: biomarker immunohistochemical expression in tissue samples Comparator: atypical LEGH, MDA/GAS and *invasive adenocarcinomas Outcomes: prevalence of positive biomarker expression Timeframe: January 1, 1975 to June 30, 2015 *classified per WHO 2003

7 Methods 2 reviewers screened abstracts of potential reports for study eligibility Eligible articles reviewed and data extracted on: IHC biomarker name, scoring details and positive-negative cut offs Case and comparator histotypes, and sample sizes Number of positive and negative test results Final selection of articles: QUADAS-2

8 Cases and Comparators Cases and comparators were grouped as: 1) Mucinous adenocarcinoma 2) Endometrioid adenocarcinoma 3) Adenosquamous carcinoma 4) Serous-clear cell carcinoma 5) MDA/GAS 6) Mesonephric carcinoma AIS cases were compared to 6 adenocarcinoma groups and to atypical LEGH (7 AIS case-comparators) 6 groups of adenocarcinoma cases were each compared to 5 groups of adenocarcinoma comparators (30 Adenocarcinoma case-comparators)

9 Biomarker positivity/prevalence analysis Combined estimates of individual biomarker positivity were calculated as weighted averages of estimates by histotype reported among the included studies Data was analyzed using unsupervised hierarchical clustering Cluster 3.0 open access software Clustering visualized via heatmaps and dendrograms Java TreeView open access software 50% or more difference in positivity interpreted as diagnostically useful

10

11 56 biomarkers Alpha-SMA: Alpha smooth muscle actin Beclin-1 CA125 CA-IX: Carbonic anhydrase Calretinin CD10 CD44s CD44v3 CD56 CDX2 CEA: Carcinoembryonic antigen Chromogranin Claudin 18 CK20 CK7 D2-40 E Cadherin EMA: Epithelial membrane antigen Epithelial specific antigen ER: Estrogen receptor GATA3 hent1 HIK1083 HNF1beta: Hepatocyte nuclear factor 1 beta hpankomab: humanized PankoMab Keratan sulfate Ki67 L1 Capsid LC3B MCM7: Minichromosome maintainance complex component 7 MMP-2: Matrix metalloproteinase 2 MUC2: Mucin 2 MUC6: Mucin 6 MUC5AC p16 p16+/ki67+ dual stain P40 p53 p63 PAX2: Paired box gene 2 PAX8: Paired box gene 8 pcea: Polypclonal carcinoembryonic antigen PR: Progesterone receptor prb: Retinoblastoma protein ProExC PTEN: Phosphatase and tensin homolog SMA SOD2: Superoxide dismutase 2 SP17: Sperm protein 17 Synaptophysin Telomerase TTF1 Ubiquitin VIL1: Villin 1 Vimentin

12 Case-comparisons AIS # Biomarkers: ranged from 1-20 Most frequently compared: p16 HIK1083 CD10 Adenocarcinoma # Biomarkers: ranged from 1-2 (mesonephric) to 1-36 (all others) Most frequently compared*: p16 HIK1083 CD10 ER PR *except mesonephric case-comparators

13 Adenocarcinoma In situ versus Mucinous adenocarcinoma Biomarker (case vs. comp positivity) Alpha SMA (0.00 vs. 1.00)

14 Mucinous adenocarcinoma versus Serous-Clear Cell carcinoma Biomarker (case vs. comp positivity) CEA (0.73 vs. 0.00) p53 (0.37 vs. 0.89)

15 Adenosquamous carcinoma versus Minimal deviation/gastric type adenocarcinoma Biomarker (case vs. comp positivity) Chromogranin (0.00 vs. 0.60) HIK1083 (0.00 vs. 0.76) p16 (0.94 vs. 0.28)

16 AIS case-comparators: 8 biomarkers with a positivity difference of 50% or more Cases versus comparators Atypical LEGH Mucinous Endometrioid Adenosquamous Serousclear cell MDA/GAS Mesonephric AIS HIK1083 Alpha- SMA* PAX8 VIL1 CEA p53 Alpha-SMA* HIK1083 p16 p53 CD10 : none with >50% difference in positivity *difference=100%

17 Adenocarcinoma case-comparators: 12 biomarkers with a positivity difference of 50% or more Mucinous Endometrioid Casecomparator Adenosquamous Serous- Clear cell MDA/GAS Mesonephric Mucinous p63 CEA, p53 Endometrioid Adenosquamous PR PR CEA, PR Claudin18, HIK1083, p16 Chromogranin, HIK1083, MUC6, p16, PR, Vimentin Chromogranin, HIK1083, p16 Calretinin CD10 CD10 Serous- Clear cell CEA p53 CEA PR CEA, HIK1083, PR (no data) MDA/GAS Claudin18, HIK1083, p16 Chromogranin, HIK1083, MUC6, P16, PR, Vimentin Chromogranin, HIK1083, p16 CEA, HIK1083, p16 Calretinin, CD10 Mesonephric Calretinin, CD10 CD10 Calretinin, CD10 : none with >50% difference in positivity

18 Conclusions and next steps Biomarker expression is understudied 15 diagnostically useful biomarkers 6/7 AIS case comparators 21/30 Adenocarcinoma case comparators Validate utility of the 15 biomarkers Standardized and consistent processing, scoring, cut offs, and more Generate algorithmic-based biomarker panels for each case-comparison Investigate knowledge gaps, identify and validate additional/new biomarkers

Conflict of interest. Gynecologic Pathology. Gynecologic Pathology

Conflict of interest. Gynecologic Pathology. Gynecologic Pathology The role of immunohistochemistry in surgical pathology of the uterine corpus and cervix, vagina and vulva Conflict of interest None (but the ovary is my favorite organ) Ålborg, June 10, 2015 Prof. Ben

More information

The incidence of cervical adenocarcinoma (ADC) has

The incidence of cervical adenocarcinoma (ADC) has Cervical Adenocarcinoma of Human Papillomavirus Positive and Human Papillomavirus Negative Tumors Edyta C. Pirog, MD, PhD Context. Cervical adenocarcinomas span a diverse group of tumors with several distinct

More information

When Immunostains Can Get You in Trouble: Gynecologic Pathology p16: Panacea or Pandora s Box?

When Immunostains Can Get You in Trouble: Gynecologic Pathology p16: Panacea or Pandora s Box? When Immunostains Can Get You in Trouble: Gynecologic Pathology p16: Panacea or Pandora s Box? Teri A. Longacre, MD Stanford Medicine Stanford California pi6 in Gynecologic Pathology: Panacea or Pandora

More information

NEW IHC A n t i b o d i e s

NEW IHC A n t i b o d i e s NEW IHC Antibodies TABLE OF CONTENTS NEW IHC ANTIBODIES from Cell Marque CITED1 (5H6).... 1 Claudin 7 (5D10F3).... 1 GATA1 (4F5).... 1 Transgelin (2A10C2).... 1 NEW IHC ANTIBODIES using RabMAb Technology

More information

Differential diagnosis of HCC

Differential diagnosis of HCC Hepatocellular Carcinoma Quest for an Ideal Immunohistochemical Panel Sanjay Kakar, MD UCSF Differential diagnosis of HCC Hepatocellular lesions Adenoma, FNH, HG dysplasia Adenocarcinoma CholangioCA, metastasis

More information

Adenocarcinoma of the Cervix

Adenocarcinoma of the Cervix Question 1. Each of the following statements about cervical adenocarcinoma is true except: Adenocarcinoma of the Cervix SAMS a) A majority of women with cervical adenocarcinoma have stage I tumors at diagnosis.

More information

3/28/2017. Disclosure of Relevant Financial Relationships. Clinical History. Pathology

3/28/2017. Disclosure of Relevant Financial Relationships. Clinical History. Pathology Disclosure of Relevant Financial Relationships Monalisa Sur MBBS, FCPath(S.A), MMED(WITS), FRCPath(U.K), FRCP( C) Professor, Department of Pathology and Molecular Medicine Division of Anatomical Pathology

More information

Diagnostically Challenging Cases in Gynecologic Pathology

Diagnostically Challenging Cases in Gynecologic Pathology Diagnostically Challenging Cases in Gynecologic Pathology Eric C. Huang, M.D., Ph.D. Department of Pathology and Laboratory Medicine University of California, Davis Medical Center Case 1 Presentation 38

More information

Urinary Bladder: WHO Classification and AJCC Staging Update 2017

Urinary Bladder: WHO Classification and AJCC Staging Update 2017 Urinary Bladder: WHO Classification and AJCC Staging Update 2017 Houston Society of Clinical Pathologists 58 th Annual Spring Symposium Houston, TX April 8, 2017 Jesse K. McKenney, MD Classification

More information

CARCINOMA OF UNKNOWN PRIMARY: DIAGNOSTIC APPROACH USING IMMUNOHISTOCHEMISTRY

CARCINOMA OF UNKNOWN PRIMARY: DIAGNOSTIC APPROACH USING IMMUNOHISTOCHEMISTRY CARCINOMA OF UNKNOWN PRIMARY: DIAGNOSTIC APPROACH USING IMMUNOHISTOCHEMISTRY Jason L Hornick, MD, PhD Director of Surgical Pathology Director of Immunohistochemistry Brigham and Women s Hospital Associate

More information

Applications of Flow Cytometry in Diagnostic Cytology of Body Cavity Fluids

Applications of Flow Cytometry in Diagnostic Cytology of Body Cavity Fluids Applications of Flow Cytometry in Diagnostic Cytology of Body Cavity Fluids Awtar Krishan, PhD. Professor, Department of Pathology University of Miami School of Medicine akrishan@med.miami.edu Beckman

More information

Immunohistochemistry in Bone and Soft Tissue Tumors. Sahar Rassi Zankoul, MD

Immunohistochemistry in Bone and Soft Tissue Tumors. Sahar Rassi Zankoul, MD Immunohistochemistry in Bone and Soft Tissue Tumors Sahar Rassi Zankoul, MD Introduction Bone tumors represent a wide variety of tumors of various origins and malignant potentials. These different tumor

More information

The available immunohistochemical stains and their

The available immunohistochemical stains and their Immunohistochemistry in Gynecologic Pathology An Example-Based Practical Update Natalia Buza, MD; Pei Hui, MD, PhD Context. Immunohistochemical stains are routinely applied in the pathology diagnostic

More information

Present Role of Immunohistochemistry in the. Subtypes. Beppe Viale European Institute of Oncology University of Milan Milan-Italy

Present Role of Immunohistochemistry in the. Subtypes. Beppe Viale European Institute of Oncology University of Milan Milan-Italy Present Role of Immunohistochemistry in the Classification of Molecular Subtypes Beppe Viale European Institute of Oncology University of Milan Milan-Italy We know it is many diseases Breast cancer is

More information

Reporting of carcinoma of unknown primary tumour (CUP)

Reporting of carcinoma of unknown primary tumour (CUP) Reporting of carcinoma of unknown primary tumour (CUP) Prof John Schofield Kent Oncology Centre with grateful thanks to Dr Karin Oien University of Glasgow Royal College of Pathologists Cancer datasets

More information

Single and Multiplex Immunohistochemistry

Single and Multiplex Immunohistochemistry Single and Multiplex Immunohistochemistry Steve Westra, BS Reagent Product Specialist Leica Biosystems IHC Theory Polyclonal vs Monoclonal Polyclonal reagents Detect a multitude of epitopes Batch to batch

More information

PROSTATIC ADENOCARCINOMA: DIAGNOSTIC CRITERIA AND IMPORTANT MIMICKERS PROSTATIC ADENOCARCINOMA: DIAGNOSTIC CRITERIA

PROSTATIC ADENOCARCINOMA: DIAGNOSTIC CRITERIA AND IMPORTANT MIMICKERS PROSTATIC ADENOCARCINOMA: DIAGNOSTIC CRITERIA PROSTATIC ADENOCARCINOMA: DIAGNOSTIC CRITERIA AND IMPORTANT MIMICKERS PROSTATIC ADENOCARCINOMA: DIAGNOSTIC CRITERIA 1 A good H & E helps! ADENOCARCINOMA DIAGNOSTIC CRITERIA Relatively uniform proliferation

More information

Title: PRIMARY SIGNET RING CELL CARCINOMA OF THE CERVIX: A CASE REPORT AND REVIEW OF THE LITERATURE

Title: PRIMARY SIGNET RING CELL CARCINOMA OF THE CERVIX: A CASE REPORT AND REVIEW OF THE LITERATURE Accepted Manuscript Title: PRIMARY SIGNET RING CELL CARCINOMA OF THE CERVIX: A CASE REPORT AND REVIEW OF THE LITERATURE Author: Veysel Sal Ilker Kahramanoglu Hasan Turan Nedim Tokgozoglu Tugan Bese Ovgu

More information

DOUBLE STAINS. Toll-Free: Direct:

DOUBLE STAINS. Toll-Free: Direct: DOUBLE STAINS CD61 + CD71 DAB Brown: CD61 Alk. Phos. Red: CD71 Bone Marrow DAB Brown: Megakaryocytes Alk. Phos. Red: Erythroid Precursors 400x CD61 (2f2) 0.1 ml concentrate............. 161M-14 0.5 ml

More information

Carcinoma of unknown primary origin (CUP) is defined

Carcinoma of unknown primary origin (CUP) is defined REVIEW ARTICLE Metastatic Carcinoma of Unknown Primary: Diagnostic Approach Using Immunohistochemistry James R. Conner, MD, PhD and Jason L. Hornick, MD, PhD Abstract: Carcinoma of unknown primary origin

More information

THYROID TUMOR DIAGNOSIS: MARKER OF THE MONTH CLUB

THYROID TUMOR DIAGNOSIS: MARKER OF THE MONTH CLUB THYROID TUMOR DIAGNOSIS: MARKER OF THE MONTH CLUB CHARACTERISTIC OF THE IDEAL TUMOR MARKER Specific Sensitive Easy to perform Easy to interpret Adaptable to FNA Reasonable cost (CHEAP) THYROID TUMOR MARKERS

More information

Invited Re vie W. Molecular genetics of ovarian carcinomas. Histology and Histo pathology

Invited Re vie W. Molecular genetics of ovarian carcinomas. Histology and Histo pathology Histol Histopathol (1 999) 14: 269-277 http://www.ehu.es/histol-histopathol Histology and Histo pathology Invited Re vie W Molecular genetics of ovarian carcinomas J. Diebold Pathological Institute, Ludwig-Maximilians-University

More information

WT1, Estrogen Receptor, and Progesterone Receptor as Markers for Breast or Ovarian Primary Sites in Metastatic Adenocarcinoma to Body Fluids

WT1, Estrogen Receptor, and Progesterone Receptor as Markers for Breast or Ovarian Primary Sites in Metastatic Adenocarcinoma to Body Fluids Anatomic Pathology / WT1, ESTROGEN RECEPTOR, AND PROGESTERONE RECEPTOR IN CYTOLOGY OF BODY FLUIDS WT1, Estrogen Receptor, and Progesterone Receptor as Markers for Breast or Ovarian Primary Sites in Metastatic

More information

GOBLET CELL CARCINOID

GOBLET CELL CARCINOID GOBLET CELL CARCINOID Hanlin L. Wang, MD, PhD University of California Los Angeles Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to

More information

Diagnostic IHC of endocrine, renal, prostate and germ cell tumor pathology

Diagnostic IHC of endocrine, renal, prostate and germ cell tumor pathology Diagnostic IHC of endocrine, renal, prostate and germ cell tumor pathology Mogens Vyberg Professor of Clinical Pathology Director of NordiQC Aalborg University Hospital, Aalborg, Denmark Markers for endocrine

More information

Objectives. Atypical Glandular Cells. Atypical Endocervical Cells. Reactive Endocervical Cells

Objectives. Atypical Glandular Cells. Atypical Endocervical Cells. Reactive Endocervical Cells 2013 California Society of Pathologists 66 th Annual Meeting San Francisco, CA Atypical Glandular Cells to Early Invasive Adenocarcinoma: Cervical Cytology and Histology Christina S. Kong, MD Associate

More information

Enterprise Interest None

Enterprise Interest None Enterprise Interest None What are triple negative breast cancers? A synopsis of their histological patterns Ian Ellis Molecular Medical Sciences, University of Nottingham Department of Histopathology,

More information

Optimization of antibodies, selection, protocols and controls Breast tumours

Optimization of antibodies, selection, protocols and controls Breast tumours Optimization of antibodies, selection, protocols and controls Breast tumours Søren Nielsen Project coordinator & Scheme Manager NordiQC Aalborg University Hospital, Denmark Breast panel: GCDFP-15 Mammaglobin

More information

A Concurrence of Adenocarcinoma with Micropapillary Features and Composite Glandular-Endocrine. cell carcinoma in the stomach.

A Concurrence of Adenocarcinoma with Micropapillary Features and Composite Glandular-Endocrine. cell carcinoma in the stomach. pissn : 2093-582X, eissn : 2093-5641 J Gastric Cancer 2016;16(4):266-270 https://doi.org/10.5230/jgc.2016.16.4.266 Case Report A Concurrence of Adenocarcinoma with Micropapillary Features and Composite

More information

Mesothelioma: diagnostic challenges from a pathological perspective. Naseema Vorajee August 2016

Mesothelioma: diagnostic challenges from a pathological perspective. Naseema Vorajee August 2016 Mesothelioma: diagnostic challenges from a pathological perspective Naseema Vorajee August 2016 Naseema.vorajee@nhls.ac.za Pleural diseases (whether neoplastic, reactive or infective) may have similar

More information

Update in Salivary Gland Pathology. Benjamin L. Witt University of Utah/ARUP Laboratories February 9, 2016

Update in Salivary Gland Pathology. Benjamin L. Witt University of Utah/ARUP Laboratories February 9, 2016 Update in Salivary Gland Pathology Benjamin L. Witt University of Utah/ARUP Laboratories February 9, 2016 Objectives Review the different appearances of a selection of salivary gland tumor types Establish

More information

Cervical FISH Testing for Triage and Support of Challenging Diagnoses: A Case Study of 2 Patients

Cervical FISH Testing for Triage and Support of Challenging Diagnoses: A Case Study of 2 Patients Cervical FISH Testing for Triage and Support of Challenging Diagnoses: A Case Study of 2 Patients Richard Hopley, MD, Alexandra Gillespie, MD* Laboratory Medicine 47:1:52-56 CLINICAL HISTORY Patients:

More information

Increased human epididymis protein 4 in benign gynecological diseases complicated with chronic renal insufficiency patients

Increased human epididymis protein 4 in benign gynecological diseases complicated with chronic renal insufficiency patients Increased human epididymis protein 4 in benign gynecological diseases complicated with chronic renal insufficiency patients Y.W. Lv, L. Yang, M. Zhang, L.H. Jiang, J.H. Niu, J. Hou and X.H. Cui Department

More information

Chapter 10: Pap Test Results

Chapter 10: Pap Test Results Chapter 10: Pap Test Results On completion of this section, the learner will be able to: 1. Identify how Pap test results are interpreted and the reasons for normal and abnormal results. 2. Describe the

More information

Update on 2015 WHO Classification of Lung Adenocarcinoma 1/3/ Mayo Foundation for Medical Education and Research. All rights reserved.

Update on 2015 WHO Classification of Lung Adenocarcinoma 1/3/ Mayo Foundation for Medical Education and Research. All rights reserved. 1 Our speaker for this program is Dr. Anja Roden, an associate professor of Laboratory Medicine and Pathology at Mayo Clinic as well as consultant in the Anatomic Pathology Laboratory and co-director of

More information

p16 Cervical HISTOLOGY Histology Compendium & Staining Atlas

p16 Cervical HISTOLOGY Histology Compendium & Staining Atlas p16 Cervical HISTOLOGY Histology Compendium & Staining Atlas Chapter 1: An Introduction to p16...... 3 Normal Cervical Epithelium and the Cell Cycle....4 HPV Infection and Cervical Disease......................................

More information

GENETIC MANAGEMENT OF A FAMILY HISTORY OF BREAST AND / OR OVARIAN CANCER. Dr Abhijit Dixit. Family Health Clinical Genetics

GENETIC MANAGEMENT OF A FAMILY HISTORY OF BREAST AND / OR OVARIAN CANCER. Dr Abhijit Dixit. Family Health Clinical Genetics GENETIC MANAGEMENT OF A FAMILY HISTORY OF BREAST AND / OR OVARIAN CANCER Full Title of Guideline: Author (include email and role): Division & Speciality: Scope (Target audience, state if Trust wide): Review

More information

Trophoblastic tumors

Trophoblastic tumors Trophoblastic tumors Uterus tumor course Oslo, 21-22/1/16 Prof. Ben Davidson, MD PhD Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Cases 45 38 39 4 Case 45

More information

Thyroid pathology Practical part

Thyroid pathology Practical part Thyroid pathology Practical part My Algorithm After a good macroscopy and a microscopic overview of the lesion, I especially look at the capsule and the thyroid just above and just beneath the capsule.

More information

Malignant neoplasms of the gastrointestinal (GI) tract,

Malignant neoplasms of the gastrointestinal (GI) tract, Special Section First Chinese American Pathologists Association Diagnostic Pathology Course, Part II Practical Immunohistochemistry in Neoplastic Pathology of the Gastrointestinal Tract, Liver, Biliary

More information

57th Annual HSCP Spring Symposium 4/16/2016

57th Annual HSCP Spring Symposium 4/16/2016 An Unusual Malignant Spindle Cell Lesion to Involve the Breast Erinn Downs-Kelly, D.O. Associate Professor of Pathology University of Utah & ARUP Laboratories No disclosures Case 39 y/o female with no

More information

Disclosures 5/27/2012. Outline of Talk. Outline of Talk. When Is LCIS Clinically Significant? Classic LCIS. Classic LCIS

Disclosures 5/27/2012. Outline of Talk. Outline of Talk. When Is LCIS Clinically Significant? Classic LCIS. Classic LCIS When Is LCIS Clinically Significant? Disclosures I have nothing to disclose Yunn-Yi Chen, MD, PhD Professor Outline of Talk Outline of Talk Classic LCIS Classic LCIS Definition of lobular differentiation

More information

Chapter 9, Part 1: Biology of Cancer and Tumor Spread

Chapter 9, Part 1: Biology of Cancer and Tumor Spread PATHOPHYSIOLOGY Name Chapter 9, Part 1: Biology of Cancer and Tumor Spread I. Cancer Characteristics and Terminology Neoplasm new growth, involves the overgrowth of tissue to form a neoplastic mass (tumor).

More information

Leydig Cell Tumors. Sex Cord Stromal Tumors of the Testis. Sex Cord Stromal Tumors of the Testis 6/5/2010

Leydig Cell Tumors. Sex Cord Stromal Tumors of the Testis. Sex Cord Stromal Tumors of the Testis 6/5/2010 Sex Cord Stromal Tumors of the Testis Sex Cord Stromal Tumors of the Testis Charles Zaloudek, M.D. Professor, Department of Pathology University of California, San Francisco 505 Parnassus Ave., M563 San

More information

Papillary adenocarcinoma of the rete testis with adjacent hyperplasia: a case report

Papillary adenocarcinoma of the rete testis with adjacent hyperplasia: a case report CASE REPORT Papillary adenocarcinoma of the rete testis with adjacent hyperplasia: a case report Carolina Polanco 1, Cooley G. Pantazis 2, Rolando Prieto 2, Kenneth A. Iczkowski 1 1. Medical College of

More information

Mesonephric adenocarcinoma of the cervix:! [INS][c] C! [/INS] ase report and literature review

Mesonephric adenocarcinoma of the cervix:! [INS][c] C! [/INS] ase report and literature review Accepted Manuscript Mesonephric adenocarcinoma of the cervix:! [INS][c] C! [/INS] ase report and literature review A. Dierickx, M. Göker, G. Braems, P. Tummers, R. Van Den Broecke PII: S2352-5789(16)30025-X

More information

DIAGNOSTIC DILEMMA. Case Reports Clinical history. Materials and Methods

DIAGNOSTIC DILEMMA. Case Reports Clinical history. Materials and Methods DIAGNOSTIC DILEMMA A Metastatic Renal Carcinoid Tumor Presenting as Breast Mass: A Diagnostic Dilemma Farnaz Hasteh, M.D., 1 Robert Pu, M.D., Ph.D., 2 and Claire W. Michael, M.D. 2 * We present clinicopathological

More information

Appropriate Use of Cytology and HPV Testing in the New Cervical Cancer Screening Guidelines

Appropriate Use of Cytology and HPV Testing in the New Cervical Cancer Screening Guidelines Appropriate Use of Cytology and HPV Testing in the New Cervical Cancer Screening Guidelines Tim Kremer, MD Ralph Anderson, MD 1 Objectives Describe the natural history of HPV particularly as it relates

More information

Histologic and Immunohistochemical Analyses of Endometrial Carcinomas. Experiences From Endometrial Biopsies in 358 Consultation Cases

Histologic and Immunohistochemical Analyses of Endometrial Carcinomas. Experiences From Endometrial Biopsies in 358 Consultation Cases Histologic and Immunohistochemical Analyses of Endometrial Carcinomas Experiences From Endometrial Biopsies in 358 Consultation Cases Jian-Jun Wei, MD; Ajit Paintal, MD; Pacita Keh, MD Context. Uterine

More information

Metastatic Carcinomas to the Uterine Cervix and Corpus

Metastatic Carcinomas to the Uterine Cervix and Corpus 10 Metastatic Carcinomas to the Uterine Cervix and Corpus Metastases to the uterus are rare, with a reported incidence of 5.9% for uterine corpus metastases and 0.3% for cervical metastases (1). Although

More information

The Diagnostic Utility of Immunohistochemistry in Undifferentiated Ovarian Carcinoma

The Diagnostic Utility of Immunohistochemistry in Undifferentiated Ovarian Carcinoma Research imedpub Journals http://www.imedpub.com/ Archives in Cancer Research DOI: 10.21767/2254-6081.1000143 The Diagnostic Utility of Immunohistochemistry in Undifferentiated Ovarian Carcinoma Hala Abdeldayem

More information

Tumour Markers. For these reasons, only a handful of tumour markers are commonly used by most doctors.

Tumour Markers. For these reasons, only a handful of tumour markers are commonly used by most doctors. Tumour Markers What are Tumour Markers? Tumour markers are substances that can be found in the body when cancer is present. They are usually found in the blood or urine. They can be products of cancer

More information

Well-differentiated Papillary Mesothelioma of the Pleura Diagnosed by Video-Assisted Thoracic Surgical Pleural Biopsy : A Case Report

Well-differentiated Papillary Mesothelioma of the Pleura Diagnosed by Video-Assisted Thoracic Surgical Pleural Biopsy : A Case Report Showa Univ J Med Sci 25 1, 67 72, March 2013 Case Report Well-differentiated Papillary Mesothelioma of the Pleura Diagnosed by Video-Assisted Thoracic Surgical Pleural Biopsy : A Case Report Yuri TOMITA

More information

Pancreatitis: A Potential Pitfall in Endoscopic Ultrasound Guided Pancreatic FNA

Pancreatitis: A Potential Pitfall in Endoscopic Ultrasound Guided Pancreatic FNA Pancreatitis: A Potential Pitfall in Endoscopic Ultrasound Guided Pancreatic FNA Jack Yang, MD Department of Pathology, Medical University of South Carolina Objectives Understand the indication of EUS

More information

Original Article Adenoid cystic carcinoma of the oral cavity: immunohistochemical study of four cases

Original Article Adenoid cystic carcinoma of the oral cavity: immunohistochemical study of four cases Int J Clin Exp Pathol 2013;6(5):932-938 www.ijcep.com /ISSN:1936-2625/IJCEP1211024 Original Article Adenoid cystic carcinoma of the oral cavity: immunohistochemical study of four cases Tadashi Terada Department

More information

Villoglandular adenocarcinoma of cervix a tumour with bland cytological features: report of a case missed on cytology

Villoglandular adenocarcinoma of cervix a tumour with bland cytological features: report of a case missed on cytology Malaysian J Pathol 2003; 25(2) : CERVICAL 139 143 VILLOGLANDULAR ADENOCARCINOMA CYTOLOGY CASE REPORT Villoglandular adenocarcinoma of cervix a tumour with bland cytological features: report of a case missed

More information

Role of immunohistochemistry in the differential diagnosis of malignant small round cell tumor: a study of 38 cases

Role of immunohistochemistry in the differential diagnosis of malignant small round cell tumor: a study of 38 cases International Journal of Research in Medical Sciences Patel A et al. Int J Res Med Sci. 2015 Dec;3(12):3833-3839 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Research Article DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20151452

More information

Classification (1) Classification (3) Classification (2) Spindle cell lesions. Spindle cell lesions of bladder (Mills et al.

Classification (1) Classification (3) Classification (2) Spindle cell lesions. Spindle cell lesions of bladder (Mills et al. Non-epithelial tumours and nonepithelial tumour-like lesions of the bladder Dr Jonathan H Shanks The Christie NHS Foundation Trust, Manchester, UK Classification (1) Myofibroblastic proliferations and

More information

Coordinate Expression of Cytokeratins 7 and 20 in Prostate Adenocarcinoma and Bladder Urothelial Carcinoma

Coordinate Expression of Cytokeratins 7 and 20 in Prostate Adenocarcinoma and Bladder Urothelial Carcinoma Anatomic Pathology / CYTOKERATINS 7 AND 20 IN PROSTATE AND BLADDER CARCINOMAS Coordinate Expression of Cytokeratins 7 and 20 in Prostate Adenocarcinoma and Bladder Urothelial Carcinoma Nader H. Bassily,

More information

Disclosures. Parathyroid Pathology. Objectives. The normal parathyroid 11/10/2012

Disclosures. Parathyroid Pathology. Objectives. The normal parathyroid 11/10/2012 Disclosures Parathyroid Pathology I have nothing to disclose Annemieke van Zante MD/PhD Assistant Professor of Clinical Pathology Associate Chief of Cytopathology Objectives 1. Review the pathologic features

More information

Endometrial pathology. Dr Tom Dodd and Dr Georgina England

Endometrial pathology. Dr Tom Dodd and Dr Georgina England Endometrial pathology Dr Tom Dodd and Dr Georgina England Case 1 Female age 35 Case 1 Proliferative endometrium Case 2 Female age 38 Case 2 Secretory endometrium Dating endometrium Assessed on the

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Urinary Tumor Markers for Bladder Cancer File Name: Origination: Last CAP Review: Next CAP Review: Last Review: urinary_tumor_markers_for_bladder_cancer 5/2011 11/2017 11/2018

More information

Pathology of the Urachus

Pathology of the Urachus Pathology of the Urachus Gladell P. Paner, MD, (BS) MT Departments of Pathology and Surgery, Section of Urology University of Chicago, Chicago, IL USA Gladell.paner@uchospitals.edu Updates in Epithelial

More information

Spindle Cell CA SPINDLE CELL LESIONS OF THE BREAST. Mammary Spindle Cell Lesions 04/13/2017

Spindle Cell CA SPINDLE CELL LESIONS OF THE BREAST. Mammary Spindle Cell Lesions 04/13/2017 Melinda F. Lerwill, MD Massachusetts General Hospital Harvard Medical School SPINDLE CELL LESIONS OF THE BREAST Mammary Spindle Cell Lesions Spindle cell carcinoma Fibromatosis Nodular fasciitis PASH Myofibroblastoma

More information

Frequent β-catenin gene mutations in atypical polypoid adenomyoma of the uterus,

Frequent β-catenin gene mutations in atypical polypoid adenomyoma of the uterus, Human Pathology (2014) 45, 33 40 www.elsevier.com/locate/humpath Original contribution Frequent β-catenin gene mutations in atypical polypoid adenomyoma of the uterus, Hiroyuki Takahashi MD, PhD a, Tsutomu

More information

Testicular Germ Cell Tumors; A Simplistic Approach

Testicular Germ Cell Tumors; A Simplistic Approach Testicular Germ Cell Tumors; A Simplistic Approach Merce Jorda, MD, PhD, MBA Professor and Vice Chair, Director of Anatomic Pathology Director of Genitourinary Pathology Service Interim Director of Cytopathology

More information

Test Bank for Robbins and Cotran Pathologic Basis of Disease 9th Edition by Kumar

Test Bank for Robbins and Cotran Pathologic Basis of Disease 9th Edition by Kumar Link full download:https://getbooksolutions.com/download/test-bank-for-robbinsand-cotran-pathologic-basis-of-disease-9th-edition-by-kumar Test Bank for Robbins and Cotran Pathologic Basis of Disease 9th

More information

This article attempts to avoid the repeating of prior organ-specific

This article attempts to avoid the repeating of prior organ-specific Application of Immunohistochemistry to Cytology Larry J. Fowler, MD; Whitney A. Lachar, MD Context. The uses of monoclonal antibodies via immunochemistry have been reported frequently within the literature

More information

Update on Thyroid FNA The Bethesda System. Shikha Bose M.D. Associate Professor Cedars Sinai Medical Center

Update on Thyroid FNA The Bethesda System. Shikha Bose M.D. Associate Professor Cedars Sinai Medical Center Update on Thyroid FNA The Bethesda System Shikha Bose M.D. Associate Professor Cedars Sinai Medical Center Thyroid Nodules Frequent occurrence Palpable: 4-7% of adults Ultrasound: 10-31% Majority benign

More information

Effective January 1, 2018 ICD O 3 codes, behaviors and terms are site specific

Effective January 1, 2018 ICD O 3 codes, behaviors and terms are site specific Effective January 1, 2018 codes, behaviors and terms are site specific Status /N 8010/3 Urachal carcinoma (C65.9, C66.9, C67. _, C68._) 8013/3 Combined large cell neuroendocrine carcinoma (C34. _, C37.9)

More information

Chapter 3 Metastases and Mimics of Colorectal Carcinoma

Chapter 3 Metastases and Mimics of Colorectal Carcinoma Chapter 3 Metastases and Mimics of Colorectal Carcinoma Abstract Secondary involvement of the colon by other malignant neoplasms may mimic primary colorectal carcinoma and results from direct extension,

More information

Background. Background. Background. Background 2/2/2015. Endometriosis-Associated Ovarian Cancer: Malignant Transformation of Endometriosis

Background. Background. Background. Background 2/2/2015. Endometriosis-Associated Ovarian Cancer: Malignant Transformation of Endometriosis Endometriosis-Associated Ovarian Cancer: Malignant Transformation of Endometriosis I have no disclosures. Marcela G. del Carmen, MD, MPH Associate Professor Division of Gynecologic Oncology EOC is gynecologic

More information

What s new in breast pathology? Penny Barnes MD, FRCP(C) May 17, 2016

What s new in breast pathology? Penny Barnes MD, FRCP(C) May 17, 2016 What s new in breast pathology? Penny Barnes MD, FRCP(C) May 17, 2016 Outline IHC markers of metastatic carcinoma of breast origin Uses and limitations of e-cadherin IHC Breast neoplasms with limited metastatic

More information

ROLE OF TTF-1, CK20, AND CK7 IMMUNOHISTOCHEMISTRY FOR DIAGNOSIS OF PRIMARY

ROLE OF TTF-1, CK20, AND CK7 IMMUNOHISTOCHEMISTRY FOR DIAGNOSIS OF PRIMARY Y.C. Su, Y.C. Hsu, and C.Y. Chai ROLE OF TTF-1, CK20, AND CK7 IMMUNOHISTOCHEMISTRY FOR DIAGNOSIS OF PRIMARY AND SECONDARY LUNG ADENOCARCINOMA Yue-Chiu Su 1, Yu-Chang Hsu 2, and Chee-Yin Chai 1,3 Departments

More information

Guidelines for Pathologic Diagnosis of Malignant Mesothelioma. A Consensus Statement from the International Mesothelioma Interest Group

Guidelines for Pathologic Diagnosis of Malignant Mesothelioma. A Consensus Statement from the International Mesothelioma Interest Group Guidelines for Pathologic Diagnosis of Malignant Mesothelioma A Consensus Statement from the International Mesothelioma Interest Group Aliya N. Husain, MD; Thomas V. Colby, MD; Nelson G. Ordóñez, MD; Thomas

More information

VULVAR CARCINOMA. Page 1 of 5

VULVAR CARCINOMA. Page 1 of 5 VULVAR CARCINOMA EXAMPLE OF A VULVAR CARCINOMA USING PROPOSED TEMPLATE Case: Invasive squamous cell carcinoma arising in D-VIN Tumor in left labia major Left partial vaginectomy and sentinel lymph node

More information

Case presentation 04/13/2017. Genomic/morphological classification of endometrial carcinoma

Case presentation 04/13/2017. Genomic/morphological classification of endometrial carcinoma Genomic/morphological classification of endometrial carcinoma Robert A. Soslow, MD soslowr@mskcc.org architecture.about.com Case presentation 49 year old woman with vaginal bleeding Underwent endometrial

More information

Spontaneous reproductive pathology in female guinea pigs

Spontaneous reproductive pathology in female guinea pigs 665429VDIXXX10.1177/1040638716665429Spontaneous reproductive pathology in guinea pigsveiga-parga, La Perle, Newman research-article2016 Full Scientific Report Spontaneous reproductive pathology in female

More information

Cytological Sub-classification of Lung Cancer: Morphologic and Molecular Characteristics. Mercè Jordà, University of Miami

Cytological Sub-classification of Lung Cancer: Morphologic and Molecular Characteristics. Mercè Jordà, University of Miami Cytological Sub-classification of Lung Cancer: Morphologic and Molecular Characteristics Mercè Jordà, University of Miami Mortality Lung cancer is the most frequent cause of cancer incidence and mortality

More information

Biopsy Interpretation of Spindle cell proliferations of the Serosa

Biopsy Interpretation of Spindle cell proliferations of the Serosa Biopsy Interpretation of Spindle cell proliferations of the Serosa Richard Attanoos, Cardiff. U.K. Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee)

More information

CASE REPORT Malignant transformation of breast ductal adenoma: a diagnostic pitfall

CASE REPORT Malignant transformation of breast ductal adenoma: a diagnostic pitfall Malaysian J Pathol 2015; 37(3) : 281 285 CASE REPORT Malignant transformation of breast ductal adenoma: a diagnostic pitfall Hiroko HAYASHI, Hiroshi OHTANI,* Junzo YAMAGUCHI,** and Isao SHIMOKAWA Department

More information

HPV Genotyping: A New Dimension in Cervical Cancer Screening Tests

HPV Genotyping: A New Dimension in Cervical Cancer Screening Tests HPV Genotyping: A New Dimension in Cervical Cancer Screening Tests Lee P. Shulman MD The Anna Ross Lapham Professor in Obstetrics and Gynecology and Chief, Division of Clinical Genetics Feinberg School

More information

PD-L1 Analyte Control DR

PD-L1 Analyte Control DR Quality in Control PD-L1 Analyte Control DR PD-L1_PI_v2 Product Codes: HCL019, HCL020 and HCL021 Contents PD-L1 Analyte Control DR 2 What is PD-L1? 3 The Role of PD-L1 in Cancer 3 PD-L1 Assessment 4 PD-L1

More information

The pathologic diagnosis of malignant mesothelioma

The pathologic diagnosis of malignant mesothelioma Review Articles Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group Aliya Noor Husain, MD; Thomas V.

More information

Goblet Cell Carcinoids of the Appendix. Immunophenotype and Ultrastructural Study

Goblet Cell Carcinoids of the Appendix. Immunophenotype and Ultrastructural Study Goblet Cell Carcinoids of the Appendix Immunophenotype and Ultrastructural Study R. Kanthan, MBBS, MS, FRCS, FRCPC; A. Saxena, MBBS, MD, FRCPC, FCAP; S. C. Kanthan, MBBS, FRCS, FRCSC Background. Goblet

More information

PITFALL. An unexpected or unforeseen difficulty or danger (A trap) Not the same as an error! PITFALLS IN DIAGNOSING SOFT TISSUE TUMORS

PITFALL. An unexpected or unforeseen difficulty or danger (A trap) Not the same as an error! PITFALLS IN DIAGNOSING SOFT TISSUE TUMORS SURGICAL PATHOLOGIC DIAGNOSIS OF SOFT TISSUE TUMORS: AVOIDING PITFALLS Christopher D.M. Fletcher M.D. FRCPath Brigham and Women s Hospital and Harvard Medical School Boston, MA PITFALL An unexpected or

More information

Animal Model. Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

Animal Model. Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases American Journal of Pathology, Vol. 163, No. 5, November 2003 Copyright American Society for Investigative Pathology Animal Model Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast

More information

5. Summary of Data Reported and Evaluation

5. Summary of Data Reported and Evaluation 168 IARC MONOGRAPHS VOLUME 91 5. Summary of Data Reported and Evaluation 5.1 Exposure data The first oral hormonal contraceptives that were found to inhibit both ovulation and implantation were developed

More information