Urinary Tract Infection in Men

Transcription

1 C H A P T E R 1 9 Urinry Trct Infection in Men Toms L. Griebling, MD Associte Professor & Vice Chir of Urology University of Knss Knss City, Knss

2 Contents INTRODUCTION DEFINITION AND DIAGNOSIS RISK FACTORS PREVALENCE AND INCIDENCE TRENDS IN HEALTHCARE RESOURCE UTILIZATION Inptient Cre Outptient Cre Emergency Room Nursing Homes ECONOMIC IMPACT SPECIAL CONSIDERATIONS CONCLUSIONS RECOMMENDATIONS

3 Urinry Trct Infection in Men Toms L. Griebling, MD INTRODUCTION Although urinry trct infections (UTI) occur in both men nd women, clinicl studies suggest tht the overll prevlence of UTI is higher in women. Bsic concepts relted to the definition nd dignosis of UTI, ssocited risks of morbidity nd mortlity, nd generl tretment principles re reviewed in the introduction to the chpter on UTI in Women. This chpter ddresses resource utiliztion, epidemiology, nd costs of UTI in dult men. DEFINITION AND DIAGNOSIS Clinicl The clinicl definitions of generl UTI, including bcteriuri, cystitis, nd pyelonephritis, re reviewed in the introduction to the chpter on UTI in women. As described bove, mle ntomic structures tht my be involved with infectious processes include the prostte, testis, scrotum, nd epididymis. Anlytic Anlyses presented in this chpter used ICD- 9 dignostic codes for UTI (Tble 1). These codes re bsed primrily on the site nd type of infection involved. RISK FACTORS Unlike the epidemiology of UTI in femles, rtes re much lower in young dults nd rise drmticlly in older men. Indeed, severl potentil risk fctors for the development of UTI re unique to men. Bldder outlet obstruction due to benign prosttic hyperplsi (BPH) my be ssocited with urinry stsis. Even though cusl reltionship hs been difficult to prove, chronic prosttic obstruction is thought to increse the risk of UTI in older men with BPH. Instrumenttion of the urinry trct my led to itrogenic UTI, either from cystoscopy or ctheteriztion, both of which re common in the evlution of men with obstructive voiding symptoms. UTI is n uncommon compliction of trnsrectl prostte biopsy. Complictions my rnge from cute prosttitis nd cystitis to more complex infections, including pyelonephritis, osteomyelitis, nd systemic urosepsis. The most common ssocited orgnisms re gstrointestinl flor, including nerobes. Most clinicins utilize ntimicrobil prophylxis round the time of the procedure. Fluoroquinolones re prticulrly effective for this condition. Bcteril prosttitis, which my be cute or chronic, is n uncommon clinicl problem. Severl forms of prosttitis re recognized in the Ntionl Institutes of Helth (NIH) clssifiction system (1). Acute bcteril prosttitis (Type I) is chrcterized by rpid onset of symptoms, including fever nd ssocited constitutionl signs nd symptoms. Urine cultures re typiclly positive, nd intrvenous ntimicrobil therpy is often indicted. In contrst, chronic bcteril prosttitis (Type II) tends to be less pronounced in onset, with ptients remining symptomtic between recurrent episodes. Recurrent cystitis is common. This is most likely due to persistence of pthogenic orgnisms in the prosttic 623

4 Urologic Diseses in Americ Tble 1. Codes used in the dignosis nd mngement of mle urinry trct infection Mles 18 yers or older with one of the following ICD-9 codes: Orchitis Tuberculosis of other mle genitl orgns Mumps orchitis Infected hydrocele Orchitis epididymitis nd epididymo-orchitis with bscess Other orchitis, epididymitis, nd epididymo-orchitis, without mention of bscess Orchitis nd epididymitis, unspecified Other orichitis epididymitis nd epididymo-orchitis without bscess Other inflmmtory disorders of mle genitl orgns Seminl vesiculitis Cystitis Cndidisis of other urogenitl sites Schistosomisis, unspecified Acute cystitis Chronic interstitil cystitis Other chronic cystitis Trigonitis Other specified types of cystitis Cystitis, unspecified Pyelonephritis Chronic pyelonephritis Chronic pyelonephritis without lesion of renl medullry necrosis Chronic pyelonephritis with lesion of renl medullry necrosis Acute pyelonephritis Acute pyelonephritis without lesion of renl medullry necrosis Acute pyelonephritis with lesion of renl medullry necrosis Renl nd perinephric bscess Pyeloureteritis cystic Other pyelonephritis or pyonephrosis, not specified s cute or chronic Infection of kidney, unspecified Other specified disorders of kidney nd ureter Other Other urethritis Urinry trct infection site not specified Other inflmmtory disorders of penis Blnoposthitis 624

5 Urinry Trct Infection in Men secretory system. Coliform bcteril species, prticulrly Enterococcus feclis nd Escherichi coli, re the most common orgnisms in cses of chronic bcteril prosttitis. Nonbcteril prosttitis (Type III), lso known s chronic pelvic pin syndrome, is condition chrcterized by chronic pelvic pin tht is ttributed to the prostte. Ptients my lso complin of obstructive nd irrittive urinry symptoms, sexul dysfunction, nd penile, testiculr, or groin pin. Chronic pelvic pin syndrome my be ssocited with incresed concentrtions of inflmmtory cells in prosttic secretions, despite the bsence of documentble bcteril infection. The pthogenesis of prosttitis my be multifctoril. Reflux of infected urine into the prosttic ducts in the posterior urethr occurs in some ptients, while scending urethrl infection plys role in others. Hemtogenous nd lymphtic spred hve lso been hypothesized s possible cuses. Reflux of noninfected urine my be ssocited with cses of nonbcteril prosttitis. It is hypothesized tht this intrprosttic reflux of urine my led to histochemicl inflmmtory chnges in the bsence of bcteri. Prosttic bscess is loclized infection in the prostte. Ptients t incresed risk for development of prosttic bscesses include dibetics nd men who re immunocompromised. Urethrl instrumenttion nd chronic indwelling ctheters my lso increse risk. Historiclly, prosttic bscesses were cused by Neisseri gonorrhe. Tody, however, most cses re ssocited with coliform orgnisms, Pseudomons spp., nd nerobic orgnisms. Urethritis nd epididymitis re generlly pinful conditions cused by bcteril infection of the urethr nd epididymis, respectively. Both disorders my be cute or chronic. These re considered seprtely in the chpter on sexully trnsmitted diseses (STDs). Orchitis is often ssocited with bcteril epididymitis. Isolted bcteril orchitis is less common. Mumps orchitis represents specific form of the disese; it occurs in bout 30% of mumps cses in postpubertl boys. The cute inflmmtion tht occurs in these cses my led to testiculr trophy nd subsequent infertility. Other forms of orchitis include tuberculous orchitis, gngrenous orchitis, nd testiculr inflmmtion ssocited with infected hydroceles. In older men, most orchitis is probbly relted to bcteril UTI; however, in younger men, it usully represents compliction of sexully trnsmitted urethritis. These differences explin some of the demogrphic differences in hospitliztion rtes for orchitis noted lter in this chpter. Orchitis is lso ddressed in the chpters on STDs nd peditric UTIs. Scrotl infections my involve only the scrotl skin or my lso include deeper structures. Fournier s gngrene is severe form of scrotl infection ssocited with necrotizing fsciitis. Predisposing risk fctors include dibetes, immunosuppression, poor perinel hygiene, nd perirectl or perinl infections. Cultures typiclly yield mixed flor with both erobic nd nerobic species. The risk of mortlity with Fournier s gngrene is high becuse the infection cn spred quickly long the lyers of the bdominl wll tht re contiguous with the scrotum. Aggressive surgicl debridement nd intrvenous ntimicrobil therpy re indicted. PREVALENCE AND INCIDENCE Approximtely 20% of ll UTIs occur in men. Between 1988 nd 1994, the overll lifetime prevlence of UTI in men ws estimted to be 13,689 cses per 100,000 dult men, bsed on the Ntionl Helth nd Nutrition Exmintion Survey (NHANES-III) (Tbles 2 nd 3). In comprison, the estimte for women ws 53,067 cses per 100,000 dult women during the sme time period (Chpter 6, Tble 2). Dt from US Veterns Helth Administrtion (VA) fcilities supports the higher prevlence of UTI in women compred to men (Chpter 6, Figure 1 nd Tble 4). Between 1999 nd 2001, the overll prevlence of UTI s primry dignosis in veterns seeking outptient cre ws 2.3 to 2.48 times greter in women thn it ws in men. Rtes of orchitis were generlly higher thn either cystitis or pyelonephritis when considered s either the primry or ny dignosis. Rtes of UTI incresed with ge in this cohort nd were higher in Africn Americn men thn in other rcil/ethnic groups (Tble 4). The VA dt show tht overll rtes of outptient visits ssocited with primry dignosis of UTI mong dult mle veterns dropped stedily between 1999 nd 2001; this trend ws most pronounced for older 625

6 Urologic Diseses in Americ Tble 2. Mle lifetime prevlence of urinry trct infections, by socio-demogrphic group, count, rte Count Rte Totl count b 11,892,613 13, Bldder infections ever 8,983,769 10, Bldder infections ever 2,908,845 3,348 Men number of infections in the lst 12 months of those ever hving UTI Rce/ethnicity White non-hispnic 9,864,439 14,458 Blck non-hispnic 932,376 10,326 Hispnic 909,324 13,229 Other 186,474 6,782 Region Midwest 3,327,654 15,899 Northest 2,379,704 13,285 South 4,319,184 14,625 West 1,866,072 10,085 Urbn/rurl MSA 5,585,151 8,688 Non-MSA 6,307,463 27,919...dt not vilble. MSA, metropolitn sttisticl re. Rte per 100,000 bsed on 1991 popultion estimtes from Current Popultion Survey (CPS), CPS Utilities, Unicon Reserch Corportion, for relevnt demogrphic ctegories of US mle dult civilin non-institutionlized popultion. b The dt in this tble re bsed on the weighted number of persons who responded 1 or more to question HAK4: How mny times hve you hd bldder infection, lso clled urinry trct infection, UTI or cystitis? NOTE: Counts my not sum to totl due to rounding. SOURCE: Ntionl Helth nd Nutrition Exmintion Survey III, Tble 3. Mle incidence of UTI in pst 12 months, by socio-demogrphic group, count, rte Count Rte Totl count b 2,013,448 2,318 1 or more bldder infections in the lst 12 months 2,013,448 2,318 Men number of infections in the lst 12 months , ,050 1, ,245 1, ,969 2, ,659 2, ,123 5, ,354 6, ,842 7,754 Rce/ethnicity White non-hispnic 1,505,602 2,207 Blck non-hispnic 209,061 2,315 Hispnic 180,689 2,629 Other 118,096 4,295 Region Midwest 495,025 2,365 Northest 334,275 1,866 South 846,422 2,866 West 337,725 1,825 Urbn/rurl MSA 837,678 1,303 Non-MSA 1,175,769 5,204 MSA, metropolitn sttisticl re. Rte per 100,000 bsed on 1991 popultion estimtes from Current Popultion Survey (CPS), CPS Utilities, Unicon Reserch Corportion, for relevnt demogrphic ctegories of US mle dult civilin non-institutionlized popultion. b The dt in this tble re bsed on the weighted number of persons who responded 1 or more to question HAK5: How mny of these infections did you hve during the pst 12 months? NOTE: Counts my not sum to totl due to rounding. SOURCE: Ntionl Helth nd Nutrition Exmintion Survey III,

7 Urinry Trct Infection in Men 100% 80% Mle Femle 60% 40% 20% 0% Overll Cystitis Pyelonephritis Other Type of UTI Figure 1. Percent contribution of mles nd femles to types of urinry trct infections, SOURCE: Outptient Clinic File (OPC), VA Austin Automtion Center, men nd occurred cross ll rcil/ethnic groups nd geogrphic regions. TRENDS IN HEALTHCARE RESOURCE UTILIZATION Antimicrobil therpy is the primry mode of tretment for most ptients with UTI. Antimicrobil selection is tilored on the bsis of culture nd susceptibility dt following the initition of empiric therpy. Selection of ntimicrobils is guided by the severity nd loction of the individul infection nd by considertion of regionl nd locl epidemiologicl dt on bcteril resistnce. Helthcre providers tret ptients with UTI in vriety of clinicl settings. This section exmines trends in tretment ptterns for mle UTI t different sites of service. Inptient Cre Inptient cre with dministrtion of intrvenous ntimicrobils my be required to tret men with severe UTI. Incresed ptient ge ppers to be ssocited with n incresed rte of inptient tretment for UTI in men. Dt from the Centers for Medicre nd Medicid Services (CMS) from 1992 to 1998 revel tht cross ll yers of study, the rtes of inptient cre for men 65 yers of ge nd older re pproximtely 1.7 times those of men younger thn 65 (Tble 5). The younger group comprises primrily those who qulified for Medicre becuse of disbility or end-stge renl disese. The risk ppers to increse significntly with ge; rtes more thn double in men ged 85 nd older. For exmple, the rte of inptient cre in 1992 for men 85 to 94 yers of ge ws 1,678 per 100,000 (95% CI, ) compred with 777 per 100,000 (95% CI, ) for men ged 75 to 84, nd 308 per 100,000 (95% CI, ) for men 65 to 74. This trend ws similr in 1995 nd Incresed use of inptient cre my be ssocited with more severe infections in older men due to incresed comorbidity nd chnges in immune response ssocited with incresed ge. In the time period covered by the Medicre dt, rtes of inptient hospitliztion for mle UTI cre were bout 1.5 times higher in Africn Americns thn in Cucsins or Hispnics (counts in Asins nd North Americn Ntives were too low to produce relible estimtes of rtes). The rte of inptient utiliztion ws somewht higher in the South thn in other regions. Dt for 1994 to 2000 from the Helthcre Cost nd Utiliztion Project (HCUP) revel tht the rtes of inptient hospitl cre for men with primry dignosis of UTI t ny ntomic loction hve been reltively stble for young nd middle-ged men (18 to 64 yers) nd for men between ges 65 nd 74 (Tble 6). In contrst, the rtes of hospitliztion for men in the 75- to 84-yer ge group hve slowly declined, while the rtes for men over 85 hve grdully incresed over time. The rtes of inptient cre increse stedily with 627

8 Urologic Diseses in Americ Tble 4. Frequency of urinry trct infection s dignosis in mle VA ptients seeking outptient cre, rte b Primry Any Primry Any Primry Any Dignosis Dignosis Dignosis Dignosis Dignosis Dignosis Totl 2,082 2,705 1,963 2,591 1,719 2, ,351 1,475 1,429 1,620 1,586 1, ,524 1,803 1,545 1,796 1,415 1, ,663 2,022 1,634 1,995 1,492 1, ,725 2,179 1,707 2,184 1,538 2, ,013 2,623 1,894 2,499 1,695 2, ,172 2,901 1,986 2,698 1,654 2, ,695 3,581 2,361 3,211 1,979 2, ,983 5,317 3,540 4,733 2,975 4,321 Rce/ethnicity White 2,553 3,311 2,411 3,167 2,139 2,881 Blck 3,313 4,287 3,172 4,077 2,912 3,841 Hispnic 3,111 4,118 2,935 3,989 2,888 4,052 Other 2,088 2,642 1,763 2,351 1,764 2,338 Unknown 1,101 1,438 1,058 1, ,295 Region Midwest 1,989 2,606 1,892 2,503 1,578 2,132 Northest 1,784 2,304 1,646 2,128 1,449 1,910 South 2,349 3,104 2,188 2,966 1,918 2,681 West 2,103 2,640 2,043 2,608 1,861 2,471 Insurnce sttus No insurnce/self-py 1,994 2,552 1,929 2,486 1,716 2,271 Medicre/Medicre supplementl 2,560 3,412 2,254 3,087 1,928 2,702 Medicid 2,455 2,972 2,188 2,846 2,287 2,998 Privte insurnce/hmo/ppo 1,700 2,234 1,534 2,036 1,280 1,760 Other insurnce 1,830 2,338 1,868 2,361 1,519 2,039 Unknown 5,540 7,405 4,692 5,768 1,168 1,550 HMO, helth mintennce orgniztion; PPO, preferred provider orgniztion. Represents dignosis codes for mle UTIs (including cystitis, pyelonephritis, orchitis, nd other UTIs). b Rte is defined s the number of unique ptients with ech condition divided by the bse popultion in the sme fiscl yer x 100,000 to clculte the rte per 100,000 unique outptients. NOTE: Rce/ethnicity dt from clinicl observtion only, not self-report; note lrge number of unknown vlues. SOURCE: Outptient Clinic File (OPC), VA Austin Automtion Center,

9 Urinry Trct Infection in Men Tble 5. Inptient stys by mle Medicre beneficiries with urinry trct infection listed s primry dignosis, count, rte b (95% CI) Count Rte Count Rte Count Rte Totl c 74, ( ) 72, ( ) 70, ( ) Totl < 65 9, ( ) 10, ( ) 10, ( ) Totl , ( ) 61, ( ) 59, ( ) , ( ) 19, ( ) 17, ( ) , ( ) 26, ( ) 26, ( ) ,260 1,678 (1,649 1,706) 14,560 1,716 (1,689 1,744) 14,760 1,705 (1,678 1,732) 95+ 1,360 1,752 (1,659 1,844) 1,160 1,415 (1,334 1,495) 1,380 1,579 (1,496 1,661) Rce/ethnicity White 60, ( ) 59, ( ) 57, ( ) Blck 9, ( ) 10, ( ) 9, ( ) Asin ( ) ( ) Hispnic 1, ( ) 1, ( ) N. Americn Ntive ( ) 340 1,216 (1,087 1,345) Region Midwest 18, ( ) 18, ( ) 18, ( ) Northest 15, ( ) 13, ( ) 13, ( ) South 31, ( ) 30, ( ) 28, ( ) West 8, ( ) 8, ( ) 8, ( ) dt not vilble. Unweighted counts multiplied by 20 to rrive t vlues in the tble. b Rte per 100,000 Medicre beneficiries in the sme demogrphic strtum. c Persons of other rces, unknown rce nd ethnicity, nd other region re included in the totls. NOTE: Counts less thn 600 should be interpreted with cution. SOURCE: Centers for Medicre nd Medicid Services, MedPAR nd 5% Crrier File, 1992, 1995, ge, more thn doubling with ech decde beyond ge 55. In this nlysis, Asin men hd the lowest rtes of inptient hospitliztion for UTI cre, followed by Hispnics nd Cucsins. Africn Americn men hd the highest rtes of inptient utiliztion. When nlyzed by region, the lowest rtes of inptient cre were seen in the West, while rtes were similr in other geogrphic regions. Rtes of inptient cre were similr in urbn nd rurl settings. It is uncler why estimted inptient utiliztion rtes re lower in HCUP dt thn in CMS dt. Dt from HCUP lso revel tht pproximtely 10% of ll inptient cre for UTI in men is for the tretment of orchitis (Tble 7). Between 1994 nd 2000, the overll rte of inptient cre for the tretment of orchitis ws reltively stble, rnging from 12 to 14 per 100,000 popultion. Rtes pper to rise grdully with ge, the most significnt increses occurring between 65 nd 85 yers of ge. Inptient utiliztion rtes for elderly men decresed somewht in 2000 compred to prior yers. Africn Americn men hd the highest rtes of inptient utiliztion for tretment of orchitis, nd Asin men hd the lowest rtes. Inptient utiliztion rtes were slightly lower in the West thn in other regions, nd there ws no significnt difference between rtes in urbn nd rurl loctions. The men length of sty for inptient hospitliztions in men with primry dignosis of UTI decresed from 6.5 dys in 1994 to 5.1 dys in 2000 (Tble 8). Consistent with the generl trend towrd decresed use of inptient cre, this observtion in men with UTI ws noted cross ll ge groups nd 629

10 Urologic Diseses in Americ Tble 6. Inptient hospitl stys by dult mles with urinry trct infection (ny ntomic loction) listed s primry dignosis, count, rte (95% CI) Count Rte Count Rte Count Rte Count Rte Totl b 115, ( ) 111, ( ) 118, ( ) 121, ( ) , (18 23) 2, (15 20) 2, (15 19) 1, (13 17) , (31 36) 6, (28 33) 5, (26 30) 5, (25 30) , (40 46) 9, (40 46) 8, (39 43) 8, (38 42) , (66 74) 9, (59 67) 10, (59 66) 11, (59 66) , ( ) 11, ( ) 13, ( ) 13, ( ) , ( ) 23, ( ) 24, ( ) 24, ( ) , ( ) 32, ( ) 33, ( ) 35, ( ) ,309 1,931 (1,830 2,031) 17,265 1,996 (1,890 2,101) 19,962 2,025 (1,932 2,119) 21,010 2,054 (1,968 2,140) Rce/ethnicity White 68, (97 105) 68, (94 102) 68, (93 101) 68, (93 100) Blck 13, ( ) 13, ( ) 12, ( ) 12, ( ) Asin/Pcific Islnder (26 40) (24 34) 1, (29 39) 1, (40 52) Hispnic 5, (61 78) 6, (58 77) 6, (61 77) 7, (71 83) Region MSA Midwest 25, ( ) 25, ( ) 26, ( ) 26, ( ) Northest 24, ( ) 23, ( ) 23, ( ) 24, ( ) South 47, ( ) 44, ( ) 48, ( ) 49, ( ) West 17, (80 97) 17, (79 94) 19, (82 100) 21, (90 105) Rurl 26, ( ) 26, ( ) 25, ( ) 26, ( ) Urbn 88, ( ) 85, ( ) 92, ( ) 94, ( ) MSA, metropolitn sttisticl re. Rte per 100,000 bsed on 1994, 1996, 1998, 2000 popultion estimtes from Current Popultion Survey (CPS), CPS Utilities, Unicon Reserch Corportion, for relevnt demogrphic ctegories of US mle dult civilin non-institutionlized popultion. b Persons of other rces, missing or unvilble rce nd ethnicity, nd missing MSA re included in the totls. NOTE: Counts my not sum to totls due to rounding. SOURCE: Helthcre Cost nd Utiliztion Project Ntionwide Inptient Smple, 1994, 1996, 1998,

11 Urinry Trct Infection in Men Tble 7. Inptient hospitl stys by dult mles with orchitis listed s primry dignosis, count, rte (95% CI) Count Rte Count Rte Count Rte Count Rte Totl b 12, (13 15) 11, (12 13) 11, (12 13) 12, (12 13) ( ) ( ) ( ) ( ) , (9.0 11) 1, ( ) 1, ( ) 1, ( ) , (10 12) 2, (10 13) 2, (10 13) 2, (10 12) , (11 15) 1, (11 14) 2, (11 14) 2, (12 15) , (14 19) 1, (13 16) 1, (14 18) 1, (14 18) , (22 28) 1, (21 26) 1, (18 23) 1, (20 26) , (36 47) 1, (27 35) 1, (29 38) 1, (25 33) (37 64) (36 59) (36 57) (28 46) Rce/ethnicity White 6, (8.9 10) 6, ( ) 6, ( ) 6, ( ) Blck 1, (18 23) 1, (15 20) 1, (14 18) 1, (14 18) Asin/Pcific Islnder * * * * * * * * Hispnic (7.1 12) (7.3 10) (7.0 11) 1, (10 14) Region MSA Midwest 2, (12 15) 2, (12 15) 2, (11 14) 2, (10 13) Northest 3, (16 20) 2, (13 17) 2, (12 16) 2, (12 16) South 4, (13 17) 4, (12 14) 4, (13 16) 4, (13 16) West 1, (8.1 11) 1, ( ) 1, (7.1 10) 2, (8.1 11) Rurl 2, (10 14) 2, (11 14) 2, (11 14) 2, (10 13) Urbn 9, (14 16) 8, (12 13) 9, (12 14) 9, (12 14) *Figure does not meet stndrd of relibility or precision. MSA, metropolitn sttisticl re. Rte per 100,000 bsed on 1994, 1996, 1998, 2000 popultion estimtes from Current Popultion Survey (CPS), CPS Utilities, Unicon Reserch Corportion, for relevnt demogrphic ctegories of US mle dult civilin non-institutionlized popultion. b Persons of other rces, missing or unvilble rce nd ethnicity, nd missing MSA re included in the totls. NOTE: Counts my not sum to totls due to rounding. SOURCE: Helthcre Cost nd Utiliztion Project Ntionwide Inptient Smple, 1994, 1996, 1998,

12 Urologic Diseses in Americ Tble 8. Trends in men inptient length of sty (dys) for dult mles hospitlized with urinry trct infection listed s primry dignosis Length of Sty Totl Rce/ethnicity White Blck Asin/Pcific Islnder Hispnic Other Region MSA Midwest Northest South West Rurl Urbn MSA, metropolitn sttisticl re. SOURCE: Helthcre Cost nd Utiliztion Project Ntionwide Inptient Smple, 1994, 1996, 1998, geogrphic regions, nd in both rurl nd urbn hospitls. Outptient Cre Outptient cre for UTI in men is dministered in vriety of clinicl settings, including hospitl outptient clinics, physicin offices, mbultory surgery centers, nd emergency rooms. Ech of these settings ws nlyzed seprtely. Hospitl Cre Dt from the Ntionl Hospitl Ambultory Medicl Cre Survey (NHAMCS) from 1994 to 2000 revel tht hospitl outptient visits by men with UTI Tble 9. Hospitl outptient visits by dult mles with urinry trct infection, count, rte (95% CI) Primry Reson Any Reson Count Rte Count Rte , (44 122) 154, (92 259) , (33 127) 83, (44 138) , (80 193) 163, ( ) , (62 186) 152, (91 226) Rte per 100,000 bsed on 1994, 1996, 1998, 2000 popultion estimtes from Current Popultion Survey (CPS), CPS Utilities, Unicon Reserch Corportion, for relevnt demogrphic ctegories of US mle dult civilin non-institutionlized popultion. SOURCE: Ntionl Hospitl Ambultory Medicl Cre Survey Outptient, 1994, 1996, 1998, listed s ny of the resons for the visit hve been vrible (Tble 9), rnging from 91 to 175 per 100,000. When UTI ws listed s the primry reson for the hospitl ptient visit, the rtes incresed from 80 per 100,000 (95% CI, ) in 1996 to 136 per 100,000 (95% CI, ) in The rte in 2000 dropped slightly, to 124 per 100,000 (95% CI, ). These dt suggest tht there hs been generl trend towrd incresed outptient cre for UTI in men. This complements the observed decreses in inptient cre noted bove. Hospitl outptient visit dt from CMS revel similr increse in utiliztion during the pst decde (Tble 10). Among Medicre beneficiries t lest 65 yers old, rtes of hospitl outptient visits for men with UTI rose from 191 per 100,000 (95% CI, ) in 1992 to 301 per 100,000 (95% CI, ) in 1995, nd 362 per 100,000 (95% CI, ) in The most drmtic increses were observed in the oldest elderly men. In those 95 yers of ge nd older, the rtes of hospitl outptient visits more thn doubled between 1992 nd 1995 nd doubled gin between 1995 nd Rtes of hospitl outptient visits for UTI cre in men were highest in the Midwest nd South, nd the rtes in both regions hve incresed over time. In the yers for which complete dt regrding rcil/ ethnic differences in outptient hospitl utiliztion were vilble (1995 nd 1998), Hispnic men hd the highest rtes of utiliztion, followed by Africn Americn men. In 1998, the rtes for Hispnic men were 1.23 nd 1.80 times higher thn those for Africn Americns nd Cucsins, respectively (counts in 632

13 Urinry Trct Infection in Men Tble 10. Hospitl outptient visits by mle Medicre beneficiries with urinry trct infection listed s primry dignosis, count, rte b (95% CI) Count Rte Count Rte Count Rte Totl c 28, ( ) 46, ( ) 51, ( ) Totl < 65 6, ( ) 10, ( ) 11, ( ) Totl , ( ) 35, ( ) 39, ( ) , ( ) 14, ( ) 16, ( ) , ( ) 14, ( ) 15, ( ) , ( ) 6, ( ) 6, ( ) ( ) ( ) ( ) Rce/ethnicity White 18, ( ) 33, ( ) 40, ( ) Blck 6, ( ) 9, ( ) 6, ( ) Asin ( ) ( ) Hispnic 1, ( ) 2, ( ) N. Americn Ntive 580 2,883 (2,649 3,116) 700 2,504 (2,321 2,686) Region Midwest 8, ( ) 12, ( ) 15, ( ) Northest 6, ( ) 6, ( ) 7, ( ) South 8, ( ) 19, ( ) 21, ( ) West 3, ( ) 6, ( ) 7, ( ) dt not vilble. Unweighted counts multiplied by 20 to rrive t vlues in the tble. b Rte per 100,000 Medicre beneficiries in the sme demogrphic strtum. c Persons of other rces, unknown rce nd ethnicity, nd other region re included in the totls. NOTE: Counts less thn 600 should be interpreted with cution. SOURCE: Centers for Medicre nd Medicid Services, 5% Crrier nd Outptient Files, 1992, 1995, Asins were too low to produce relible estimtes of rtes). The reson for this observed difference is uncler. Physicin Offices The mjority of UTIs in both men nd women re treted in physicins offices. According to dt from the Ntionl Ambultory Medicl Cre Survey (NAMCS), more thn 1,896,000 physicin office visits tht included dignosis of UTI were mde in 2000 by men in the United Sttes (Tble 11). Of these visits, more thn 1,290,000 were for primry dignosis of UTI. Fluctutions in rtes of utiliztion hve been observed over time, with peks occurring in 1992 nd In these yers, the observed rtes of physicin office visits for UTI in men ged 55 nd older were significntly higher thn those for younger men. This likely reflects the higher incidence nd prevlence of UTI in older men. The resons for the drmtic increses in 1992 nd 1996 re uncler but my be relted to coding nomlies. Medicre dt for outptient physicin office visits for men with UTI indicte tht rtes of utiliztion remined reltively stble throughout the 1990s (Tble 12). Rtes were consistently highest in men in the 85- to 94-yer ge group, followed by those ged 75 to 84 (Figure 2). Rtes in the most elderly cohort (95 nd older) were similr to the overll men. Regionl vritions in Medicre physicin outptient visits for men with UTI pper to hve diminished over time nd were lest pronounced in As in the NHAMCS dt, Hispnic men hd the highest rtes 633

14 Urologic Diseses in Americ Tble 11. Physicin office visits by dult mles with urinry trct infection, count, rte (95% CI) Count Rte Count Rte Count Rte Count Rte Count Rte Primry Reson for Visit Totl 1,992,546 2,268 (1,598 2,938) 1,111,037 1,259 (889 1,629) 2,163,849 2,353 (1,601 3,105) 1,664,141 1,765 (1,060 2,470) 1,290,406 1,342 (854 1,830) ,067,943 1,642 (964 2,320) 682,612 1,033 (652 1,414) 1,147,995 1,669 (913 2,425) 845,264 1,205 (582 1,828) 819,947 1,153 (568 1,738) ,603 4,050 (2,340 5,760) 428,425 1,932 (993 2,872) 1,015,854 4,379 (2,412 6,346) * * 470,459 1,879 (1,013 2,745) Any Reson for Visit Totl 2,372,185 2,700 (1,997 3,402) 1,594,515 1,807 (1,368 2,245) 2,652,548 2,884 (2,093 3,675) 2,105,332 2,232 (1,447 3,018) 1,896,810 1,973 (1,377 2,568) ,203,792 1,851 (1,149 2,553) 831,728 1,258 (843 1,674) 1,243,005 1,807 (1,041 2,574) 971,180 1,384 (731 2,038) 1,153,805 1,623 (915 2,330) 55+ 1,168,393 5,118 (3,297 6,939) 762,787 3,441 (2,209 4,673) 1,409,543 6,076 (3,910 8,241) * * 743,005 2,967 (1,876 4,058) *Figure does not meet stndrd for relibility or precision. Rte per 100,000 bsed on 1992, 1994, 1996, 1998, 2000 popultion estimtes from Current Popultion Survey (CPS), CPS Utilities, Unicon Reserch Corportion, for relevnt demogrphic ctegories of US mle dult civilin non-institutionlized popultion. NOTE: Counts my not sum to totls due to rounding. SOURCE: Ntionl Ambultory Medicl Cre Survey Outptient, 1992, 1994, 1996, 1998,

15 Urinry Trct Infection in Men Tble 12. Physicin office visits by mle Medicre beneficiries with urinry trct infection listed s primry dignosis, count, rte b (95% CI) Count Rte Count Rte Count Rte Totl c 524,880 3,564 (3,555 3,574) 540,200 3,549 (3,540 3,559) 498,620 3,444 (3,435 3,453) Totl < 65 62,880 2,035 (2,019 2,051) 75,040 2,178 (2,163 2,193) 71,420 2,078 (2,063 2,093) Totl ,000 3,970 (3,959 3,981) 465,160 3,951 (3,939 3,962) 427,200 3,869 (3,858 3,880) ,780 3,202 (3,190 3,215) 231,720 3,224 (3,211 3,237) 197,840 3,078 (3,065 3,092) ,880 5,037 (5,014 5,060) 180,140 4,925 (4,903 4,947) 173,720 4,744 (4,723 4,766) ,700 6,289 (6,235 6,342) 50,300 5,929 (5,879 5,980) 52,980 6,119 (6,069 6,170) 95+ 2,640 3,400 (3,273 3,528) 3,000 3,659 (3,530 3,787) 2,660 3,043 (2,928 3,157) Rce/ethnicity White 446,400 3,599 (3,589 3,610) 464,380 3,572 (3,562 3,582) 425,500 3,480 (3,469 3,490) Blck 47,140 3,700 (3,667 3,733) 48,560 3,507 (3,476 3,538) 40,760 3,054 (3,025 3,083) Asin 2,400 3,293 (3,164 3,422) 4,700 3,427 (3,331 3,523) Hispnic 9,740 4,906 (4,811 5,001) 14,980 4,463 (4,393 4,533) N. Americn Ntive 520 2,584 (2,366 2,803) 440 1,574 (1,427 1,720) Region Midwest 126,780 3,418 (3,399 3,436) 125,900 3,266 (3,248 3,284) 113,680 3,074 (3,056 3,092) Northest 86,280 2,721 (2,703 2,739) 93,300 2,934 (2,915 2,952) 83,440 3,002 (2,982 3,022) South 223,640 4,270 (4,252 4,287) 220,600 4,021 (4,005 4,038) 210,400 3,920 (3,904 3,937) West 76,500 3,405 (3,381 3,429) 83,260 3,590 (3,567 3,614) 76,820 3,435 (3,411 3,459) dt not vilble. Unweighted counts multiplied by 20 to rrive t vlues in the tble. b Rte per 100,000 Medicre beneficiries in the sme demogrphic strtum. c Persons of other rces, unknown rce nd ethnicity, nd other region re included in the totls. NOTE: Counts less thn 600 should be interpreted with cution. SOURCE: Centers for Medicre nd Medicid Services, 5% Crrier nd Outptient Files, 1992, 1995, of physicin office utiliztion mong the rcil/ethnic groups nlyzed. Ambultory Surgery Visits to mbultory surgery centers represent smll percentge of Medicre visits for men with UTI (Tble 13). Among Medicre beneficiries t lest 65 yers old, rtes rnged from 83 per 100,000 in 1992 (95% CI, 82 85) to 93 per 100,000 in 1995 (95% CI, 92 95) nd 95 per 100,000 in 1998 (95% CI, 93 97). Rtes were lower nd more stble mong younger Medicre beneficiries who qulified becuse of disbility or end-stge renl disese. As with Medicre physicin office visits, the highest rtes were observed in men 75 to 94 yers of ge. Rtes were highest in the Midwest nd Northest nd lowest in the South nd West. The resons for these geogrphic differences re uncler. No cler rcil/ethnic differences were observed in this nlysis. The low rtes of utiliztion for mbultory surgery centers indicte tht this is not primry site of service for men with UTI. The cses identified likely represent periopertive UTI in men scheduled for outptient surgery. Emergency Room Ptients with UTI my present to n emergency room (ER) for initil evlution nd mngement. Dt from NHAMCS indicte pproximtely 424,700 ER visits by men with primry dignosis of UTI in 2000 (Tble 14). The overll rte of utiliztion in 2000 ws 442 per 100,000, which is similr to the rte of 420 per 100,000 observed in Lower rtes of ER utiliztion in this popultion were observed in 1996 nd The rtes of ER utiliztion by mle Medicre 635

16 Urologic Diseses in Americ Tble 13. Visits to mbultory surgery centers by mle Medicre beneficiries with urinry trct infection listed s primry dignosis, count, rte b (95% CI) Count Rte Count Rte Count Rte Totl c 11, (74 77) 12, (83 86) 12, (83 86) Totl < 65 1, (44 48) 1, (52 56) 1, (48 52) Totl 65+ 9, (82 85) 11, (92 95) 10, (93 97) , (73 77) 5, (80 84) 4, (75 79) , (96 102) 4, ( ) 4, ( ) (92 106) (95 108) 1, ( ) (14 37) (55 91) (32 59) Rce/ethnicity White 9, (76 80) 11, (85 88) 10, (87 90) Blck (57 66) 1, (75 84) (66 75) Asin ( ) (8.0 21) Hispnic (40 60) (63 80) N. Americn Ntive (39 104) Region Midwest 3, (89 95) 3, ( ) 3, ( ) Northest 2, (89 96) 3, (91 98) 3, ( ) South 3, (71 76) 4, (80 85) 3, (71 76) West (37 42) 1, (50 56) 1, (53 59) dt not vilble. Unweighted counts multiplied by 20 to rrive t vlues in the tble. b Rte per 100,000 Medicre beneficiries in the sme demogrphic strtum. c Persons of other rces, unknown rce nd ethnicity, nd other region re included in the totls. NOTE: Counts less thn 600 should be interpreted with cution. SOURCE: Centers for Medicre nd Medicid Services, 5% Crrier nd Outptient Files, 1992, 1995, Rte per 100, Figure 2. Physicin Office Emergency Room < Group Inptient Hospitl Outptient Trends in visits by mles with urinry trct infection listed s primry dignosis by ptient ge nd site of service, Tble 14. Emergency room visits by dult mles with urinry trct infection listed s primry dignosis, count, rte (95% CI) Count Rte , ( ) , ( ) , ( ) , ( ) Rte per 100,000 bsed on 1994, 1996, 1998, 2000 popultion estimtes from Current Popultion Survey (CPS), CPS Utilities, Unicon Reserch Corportion, for relevnt demogrphic ctegories of US mle dult civilin noninstitutionlized popultion. SOURCE: Ntionl Hospitl Ambultory Medicl Cre Survey ER, 1994, 1996, 1998, SOURCE: Centers for Medicre nd Medicid Services,

17 Urinry Trct Infection in Men Tble 15. Emergency room visits by mle Medicre beneficiries with urinry trct infection listed s primry dignosis, count, rte b (95% CI) Count Rte Count Rte Count Rte Totl c 74, ( ) 78, ( ) 76, ( ) Totl < 65 15, ( ) 17, ( ) 18, ( ) Totl , ( ) 60, ( ) 57, ( ) , ( ) 24, ( ) 23, ( ) , ( ) 25, ( ) 23, ( ) ,140 1,156 (1,133 1,180) 10,360 1,221 (1,198 1,245) 10,720 1,238 (1,215 1,262) ,108 (1,034 1,181) 940 1,146 (1,073 1,220) ( ) Rce/ethnicity White 58, ( ) 60, ( ) 58, ( ) Blck 12, ( ) 14,820 1,070 (1,053 1,087) 13, ( ) Asin ( ) ( ) Hispnic 1, ( ) 2, ( ) N. Americn Ntive ( ) 300 1,073 (951 1,195) Region Midwest 17, ( ) 18, ( ) 19, ( ) Northest 12, ( ) 13, ( ) 12, ( ) South 33, ( ) 36, ( ) 34, ( ) West 9, ( ) 8, ( ) 8, ( ) dt not vilble. Unweighted counts multiplied by 20 to rrive t vlues in the tble. b Rte per 100,000 Medicre beneficiries in the sme demogrphic strtum. c Persons of other rces, unknown rce nd ethnicity, nd other region re included in the totls. NOTE: Counts less thn 600 should be interpreted with cution. SOURCE: Centers for Medicre nd Medicid Services, 5% Crrier nd Outptient Files, 1992, 1995, beneficiries were somewht higher, rnging from 506 per 100,000 (95% CI, ) in 1992 to 527 per 100,000 (95% CI, ) in 1998 (Tble 15). In this nlysis, utiliztion rtes were consistently highest in the next-to-oldest cohort (85 to 94 yers of ge), followed closely by the oldest men (those 95 nd older). Rtes of ER utiliztion by older men were nerly twice those of men younger thn 85 yers of ge. This my represent incresed severity of infection in elderly men prompting evlution in the ER. Rtes of ER utiliztion in this cohort were consistently highest in the South. Agin, the reson for the geogrphic vrition is uncler. Africn Americn men hd rtes of ER utiliztion twice s high s those of Cucsins in this nlysis (Figure 3). The lowest rtes were observed in Asin men. Nursing Homes Informtion regrding UTI in men living in nursing home fcilities ws obtined from the Ntionl Nursing Home Survey of 1995, 1997, nd 1999 (Tbles 16 18). The overll rtes for men with either n dmitting or current dignosis of UTI in this smple pper stble over time, rnging from 5,642 per 100,000 in 1997 (95% CI, 4,641 6,642) to 5,803 per 100,000 in 1995 (95% CI, 4,794 6,812). It is interesting to note tht the rtes of UTI for men living in nursing homes re closer to those for women thn re the rtes for the community-dwelling cohorts, s discussed in the chpter on UTI in Women (see Chpter 6, Tbles 21 23). No cler trends were observed over time with regrd to ge in mle nursing home residents. In ll yers studied, bout hlf of mle nursing home residents required specil ssistnce using the toilet, 637

18 Urologic Diseses in Americ White Blck Rte per 100, Yer Figure 3. Rte of emergency room visits for mles with urinry trct infection listed s primry dignosis by ptient rce nd yer. SOURCE: Centers for Medicre nd Medicid Services, 5% Crrier nd Outptient Files, 1992, 1995, regrdless of whether they hd UTI (Tble 18). In 1997, only 39% of men with UTI required specil ssistnce using the toilet, but this survey item ws skipped t much higher rte tht yer, mking its results difficult to interpret (Tble 17). Men with UTI hd higher rtes of incontinence thn did the generl cohort of mle nursing home residents. It is not cler whether UTI or urinry incontinence is the cusl fctor. The rtes of indwelling ctheter nd ostomy use in mle nursing home residents hve remined stble t 11.9% in 1995 nd 11.3% in 1999 (Tble 18). This is of concern becuse of the well-estblished ssocition between indwelling ctheter use nd urinry trct coloniztion nd infection. Although these rtes of ctheter nd ostomy use re not drmtic, they re higher thn the 7.9 to 9.1% rnge observed in femle nursing home residents. (see Chpter 6, Tble 23). ECONOMIC IMPACT Direct Costs Urinry trct infections in men re ssocited with significnt economic cost. Adjusted men Tble 16. Mle nursing home residents with n dmitting or current dignosis of urinry trct infection, count, rte (95% CI) Count Rte Count Rte Count Rte Totl b 24,404 5,803 (4,794 6,812) 25,063 5,642 (4,641 6,642) 26,229 5,743 (4,761 6,724) ,223 5,746 (4,046 7,445) 9,158 6,011 (4,302 7,720) 9,552 5,860 (4,266 7,455) ,017 5,554 (3,886 7,223) 7,082 4,408 (2,956 5,859) 9,438 6,311 (4,397 8,225) 85+ 8,164 6,135 (4,244 8,026) 8,822 6,723 (4,629 8,817) 7,239 5,020 (3,440 6,600) Rce White 18,678 5,500 (4,403 6,597) 19,029 5,364 (4,258 6,470) 18,455 5,070 (4,052 6,087) Other 5,508 6,973 (4,453 9,493) 5,704 6,637 (4,252 9,021) 7,558 8,349 (5,608 11,089) Rte per 100,000 mle nursing home residents in the sme demogrphic strtum. b Persons of unspecified rce re included in the totl. SOURCE: Ntionl Nursing Home Survey, 1995, 1997,

19 Urinry Trct Infection in Men Tble 17. Specil needs of mle nursing home residents with urinry trct infection, count, rte (95% CI) Ctegory Count Rte Count Rte Count Rte Hs indwelling foley ctheter or ostomy Yes 6,925 28,375 (20,204 36,546) 8, ,50 (26,693 44,806) 6,880 26,229 (18,779 33,680) No 17,479 71,625 (63,454 79,796) 16,103 64,250 (55,194 73,307) 19,349 73,771 (66,320 81,221) Question left blnk Requires ssistnce using the toilet Yes 12,388 50,761 (41,692 59,830) 9,869 39,377 (30,473 48,280) 14,214 54,192 (45,293 63,092) No 4,465 18,295 (11,292 25,297) 5,885 23,483 (15,212 31,754) 4,151 15,828 (9,343 22,312) Question skipped for llowed reson 7,329 30,032 (21,702 38,363) 9,068 36,183 (27,302 45,064) 7,513 28,643 (20,417 36,869) Question left blnk (0 2,715) (0 2,850) 351 1,337 (0 3,204) Requires ssistnce from equipment when using the toilet Yes 2,546 10,433 (4,740 16,126) 2,749 10,970 (54,89 16,452) 3,038 11,581 (5,996 17,166) No 9,629 39,458 (30,628 48,288) 6,303 25,149 (17,344 32,954) 10,352 39,467 (30,808 48,125) Question skipped for llowed reson 11,794 48,327 (39,262 57,392) 14,954 59,666 (50,709 68,623) 11,664 44,470 (35,581 53,360) Question left blnk 435 1,782 (0 4,262) 1,056 4,215 (504 7,925) 1,176 4,482 (911 8,053) Requires ssistnce from nother person when using the toilet Yes 12,388 50,761 (41,692 59,830) 9,637 38,450 (29,602 47,298) 14,214 54,192 (45,293 63,092) No Question skipped for llowed reson 11,794 48,327 (39,262 57,392) 14,954 59,666 (50,709 68,623) 11,664 44,470 (35,581 53,360) Question left blnk (0 2,715) 472 1,884 (0 4,505) 351 1,337 (0 3,204) Hs difficulty controlling urine Yes 14,667 60,102 (51,208 68,997) 14,705 58,673 (49,604 67,743) 14,550 55,472 (46,703 64,240) No 5,311 21,762 (14,269 29,256) 4,728 18,865 (11,759 25,972) 6,723 25,631 (17,996 33,265) Question skipped for llowed reson 4,210 17,250 (10,366 24,135) 5,629 22,461 (14,800 30,122) 4,957 18,898 (12,329 25,467) Question left blnk (0 2,635) Rte per 100,000 mle nursing home residents with urinry trct infection in the NNHS for tht yer. SOURCE: Ntionl Nursing Home Survey, 1995, 1997,

20 Urologic Diseses in Americ Tble 18. Specil needs of mle nursing home residents regrdless of urinry trct infection dignosis, count, rte (95% CI) Ctegory Count Rte Count Rte Count Rte Hs indwelling foley ctheter or ostomy Yes 50,298 11,961 (10,569 13,352) 53,938 12,141 (10,731 13,552) 51,457 11,266 (9,941 12,591) No 369,452 87,854 (86,453 89,254) 389,880 87,762 (86,348 89,176) 401,402 87,884 (86,497 89,271) Question left blnk (3 368) (0 210) 3, (385 1,315) Requires ssistnce using the toilet Yes 207,587 49,363 (47,203 51,523) 221,599 49,882 (47,736 52,028) 241,558 52,887 (50,755 55,020) No 141,870 33,736 (31,689 35,783) 133,378 30,023 (28,069 31,977) 128,251 28,080 (26,154 30,005) Question skipped for llowed reson 69,267 16,471 (14,863 18,080) 86,814 19,542 (17,809 21,275) 81,977 17,948 (16,308 19,588) Question left blnk 1, ( ) 2, ( ) 4,956 1,085 (571 1,599) Requires ssistnce from equipment when using the toilet Yes 57,463 13,664 (12,183 15,145) 59,329 13,355 (11,901 14,809) 67,782 14,840 (13,323 16,357) No 143,213 34,055 (32,011 36,100) 149,218 33,589 (31,564 35,614) 162,895 35,665 (33,630 37,699) Question skipped for llowed reson 211,137 50,207 (48,047 52,368) 220,191 49,565 (47,419 51,711) 210,228 46,028 (43,899 48,156) Question left blnk 8,719 2,073 (1,466 2,680) 15,510 3,491 (2,702 4,281) 15,837 3,467 (2,650 4,285) Requires ssistnce from nother person when using the toilet Yes 203,490 48,389 (46,230 50,548) 217,556 48,972 (46,827 51,117) 238,252 52,163 (50,029 54,297) No 2, ( ) 2, ( ) 2, ( ) Question skipped for llowed reson 211,137 50,207 (48,047 52,368) 220,191 49,565 (47,419 51,711) 210,228 46,028 (43,899 48,156) Question left blnk 3, (451 1,239) 3, (482 1,287) 5,573 1,220 (681 1,759) Hs difficulty controlling urine Yes 218,491 51,956 (49,797 54,115) 232,536 52,344 (50,203 54,485) 242,189 53,025 (50,898 55,153) No 170,988 40,660 (38,537 42,783) 175,090 39,413 (37,325 41,500) 177,128 38,781 (36,709 40,852) Question skipped for llowed reson 29,338 6,976 (5,881 8,072) 36,416 8,197 (7,028 9,366) 34,206 7,489 (6,406 8,572) Question left blnk 1, ( ) (0 138) 3, (255 1,155) Rte per 100,000 dult mle nursing home residents in the NNHS for tht yer. SOURCE: Ntionl Nursing Home Survey, 1995, 1997,

21 Urinry Trct Infection in Men Tble 19. Estimted nnul expenditures of privtely insured employees with nd without medicl clim for UTI in 1999 Persons without UTI (N=267,520) Annul Expenditures (per person) Persons with UTI (N=11,430) Totl Totl Medicl Rx Drugs Totl $3,099 $5,470 $4,414 $1, $2,685 $5,067 $4,333 $ $2,861 $5,327 $4,398 $ $3,173 $5,752 $4,565 $1, $3,279 $5,515 $4,342 $1,173 Gender Mle $2,715 $5,544 $4,528 $1,016 Femle $3,833 $5,407 $4,325 $1,082 Region Midwest $2,988 $5,423 $4,367 $1,057 Northest $2,981 $5,197 $4,157 $1,040 South $3,310 $5,838 $4,757 $1,080 West $3,137 $5,762 $4,716 $1,046 Rx, prescription. The smple consists of primry beneficiries ges 18 to 64 hving employer-provided insurnce who were continuously enrolled in Estimted nnul expenditures were derived from multivrite models tht control for ge, gender, work sttus (ctive/retired), medin household income (bsed on zip code), urbn/rurl residence, medicl nd drug pln chrcteristics (mnged cre, deductible, co-insurnce/co-pyments), nd 26 disese conditions. SOURCE: Ingenix, helthcre expenditures for privtely insured men dignosed with UTI ws $5,544 in 1999, while the expenditure ws $2,715 for men who did not experience UTI (Tble 19). In dults without UTI, nnul helthcre expenditures were lower for men thn for women ($2,715 versus $3,833, respectively). However, there ws little difference in totl nnul helthcre expenditures for men nd women with UTI ($5,544 vs $5,407). The totl nnul estimted expenditures for outptient prescription mediction for the tretment of UTI in both men nd women between 1996 nd 1998 were estimted to exceed $96.4 million (Tble 20). Fluoroquinolones ccounted for lrge portion of these expenditures, in terms of both costs nd numbers of clims. This my reflect growing trend towrd the use of fluoroquinolones rther thn other types of ntimicrobils for the tretment of UTI. The extent to which fluoroquinolones were prescribed s first-line therpy for prosttitis nd other pproprite indictions could not be determined from this dtset. Indirect Costs Overll time lost from work due to UTI ws similr in men nd women. Although men hd only slightly higher rtes of work loss due to cystitis (18% of men vs 16% of women), men tended to miss more thn twice s much work time (10.5 hours vs 4.8 hours) (Tble 21). Men with pyelonephritis lso missed more totl time from work thn did women (11.0 hours vs 7.7 hours), lthough the percentge of men missing work ws slightly lower thn the percentge of women (21% vs 24%). Of men dignosed with orchitis in this smple, 14% reported missing work, for men totl of 7.6 hours (95% CI, ). For ech mbultory cre visit or hospitliztion for orchitis, men missed n verge of 3.8 hours of work (95% CI, ) (Tble 22). Bsed on composite dt, the overll medicl expenditures for men with UTI in the United Sttes were estimted to be pproximtely $1.028 billion in 2000 (Tble 23). This is pproximtely 2.4 times lower thn the overll mount spent to cre for women with UTI during the sme time period (see UTI in Women, 641