By J. Jayasutha Lecturer Department of Pharmacy Practice SRM College of Pharmacy SRM University

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1 By J. Jayasutha Lecturer Department of Pharmacy Practice SRM College of Pharmacy SRM University

2 Cessation of menstruation as a result of the aging process of or surgical removal of the ovaries; change from fertility to infertility. Physiological changes that take place within women between the ages of 30 to 60. Hormone levels change in female body; practically the production of estrogen. Perimenopause and menopause can last 10 plus years. Menopause itself begins 12 months after a woman s final period.

3 Cycles become irregular Erratic or heavy bleeding Decrease in sexual response Irritability/Mood Swings Fatigue Forgetfulness

4 Headache Hot flashes Night sweats Vaginal dryness Dry skin Bone loss Urinary incontinence

5 Supplemental hormones: Estrogen, progesterone, and testosterone. Estrogen and progesterone can be made from plants of from synthetic chemicals. Delivery options: pills, patches, creams, inserted into vagina by means of creams, tablets or ring, placed under skin by implants or by injection; future: nasal spray.

6 Maintains thickness and vascularity of vaginal and urethral tissue for comfort and lubrication during sexual interaction. Reduces hot flashes and sleep disturbances from night sweats. Protects against osteoporosis and resultant fractures, particularly of the hip. Reduces risk of colon cancer

7 Estrogen in the Environment Cow and Chicken Farms-Range Feed Plastic Pesticides Diet Metabolism

8 Research looking at lower doses of HTR Balance of estrogen and progesterone Progesterone Cream Stress Relief Liver Cleansing

9 Breast cancer In 2003 there was 14,000 less cases of breast cancer possibly due to the decrease in women taking HRT If a woman is diagnosed with breast cancer while taking HRT, she is advised to stop immediately. Endometrial cancer Cardiovascular disease Stroke Blood clots

10 Weight gain Bloating Breast tenderness Irregular bleeding Some do not take HRT for fear of cancer Some physicians recommend a discontinuation of HRT

11 One study indicated 68 percent of women have tried alternative therapies and 62 percent were satisfied with the results. Diet and Exercise are the most common.

12 Soy isoflavones in soy products Relieves a number of symptoms, including hot flashes, night sweats, fatigue and vaginal dryness Soy has also been shown to assist the body in absorbing and retaining calcium, suppress bone loss, lower LDL cholesterol and decrease blood clotting Recommended daily amount is 25 grams of soy protein and mg of isoflavones as a starting amount and could gradually increase to two to three times that amount Seen to reduce symptoms in 4 out of 10 women

13 Black Cohosh Has been seen to reduce hot flashes Potential for liver damage and shouldn t take more than 6 months Calcium, magnesium and vitamins D & E Magnesium promotes bone density RDA is 600 mg, although most Americans only consume 300 mg

14 Exercise A study in Sweden showed that out of 1,323 women, 15 percent sedentary women demonstrated hot flash symptoms compared to only five percent of the physically active subjects Weight bearing exercises and strength training strengthens bones and muscles, enhances self-esteem and creates a positive outlook, promotes sleep and increases levels of neurotransmitters in the brain Serotonin (calming effect), endorphins (pain killers), and dopamine (alertness and concentration).

15 Smoking cessation Reduces risk for pretty much everything! Avoiding spicy foods for those who get heartburn Can reduce severity and frequency of hot flashes Limiting or eliminating caffeine Promotes sleep Relaxation methods Helps with mood swings/irritability

16 Acupuncture Reflexology Controlling weight and avoiding weight gain Preparing for hot weather by wearing layers of clothing and bringing a small fan

17 Controversial subject Limited extensive scientific research Limitations on the studies conducted HRT or not? History of breast cancer Presence of other risk factors

18 THANK YOU

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