INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE

Size: px
Start display at page:

Download "INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE"

Transcription

1 INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE FORMULATION AND EVALUATION OF PAROXETINE HYDROCHLORIDE ORODISPERSIBLE TABLETS USING TAPIOCA STARCH A. BHARATHI *, K N V DEEPTHI, S. BHAGYA LAKSHMI, RAMCHANDRA KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada , Andhra Pradesh, India Accepted Date: 07/12/2014; Published Date: 27/02/2015 Abstract: Paroxetine hydrochloride is a potent selective serotonin reuptake inhibitor (SSIR) used as an antidepressant. The present investigation involved in preparing and evaluating Paroxetine hydrochloride orodispersible tablets. The present study also involved in introducing and evaluating the super disintegrant action of a natural excipient tapioca starch. Orodispersible tablets of paroxetine hydrochloride were prepared using tapioca starch in different strengths 2.5%, 5%, 7.5%, 10% as superdisintegrant by direct compression and evaluated. Tablets were also prepared by using crospovidone and sodium starch glycolate (in strengths 2.5%, 5%, 7.5%, 10%) as superdisintegrants for comparision. Effect of diluents like dicalcium phosphate and D-mannitol was also evaluated. Flow propertie of powder blends were evaluated. All the formulations prepared were evaluated for post compression parameters like hardness, friability, weight variation, disintegration time and results were found to be within good limits. Paroxetine hydrochloride ODT tablets (200mg) were prepared employing tapioca starch disintegrated within 30sec showing rapid and maximum release of drug in 5min when compared to those tablets prepared by using other synthetic super disintegrants. Tablets containing dicalcium phosphate as diluent shown better results compared to that of D-mannitol. Thus tapioca starch, a natural excipient was found to be promising superdisintegrant in preparation of orodispersible tablets effectively in the strengths of 2.5%, 5%, 7.5%, 10%. Keywords: Paroxetine hydrochloride ODT, Tapioca starch, Crospovidone, Sodium starch glycolate, Dicalcium phosphate, D-mannitol. Corresponding Author: MS. A. BHARATHI Access Online On: PAPER-QR CODE How to Cite This Article: 36

2 INTRODUCTION Orodispersible tablet dosage form is an useful dosage form for geriatrics, pediatrics, mentally disabled, bed-ridden and patients those experience dysphasia. It does t require water for swallowing. Due to pregastric absorbtion of drug it may also avoid first-pass metabolism 1. European Pharmacopoeia 2 has used the term orodispersible tablet for tablets that disperse readily and within three minutes before swallowing. The US Food and Drug Administration, Center for Drug Evaluation and Research (CDER) defines, in the Orange Book, an ODT as A solid dosage form containing medicinal substances, which disintegrates rapidly, usually within a matter of seconds(30sec), when placed upon the tongue 3. Paroxetine 4,5,6 belongs to selective serotonin reuptake inhibitor category. It is used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms (e.g. hot flashes and night sweats) associated with menopause in adults. It undergoes extensive first pass metabolism in liver. Some patients have difficulty in swallowing and are less like to continue dosage regimen. Navvaro et al 7 found that orodispersible type of tablets may improve patient compliance for depressive patients who undergo swallowing difficulties, nausea, limited liquid intake and also preffered for patients without these difficulties. There are synthetic excipients like crospovidone, croscarmellose sodium, sodium starch glycolate used as superdisintegrants. Natural excipients like banana powder, sago starch, corn starch, rice starch, yam starch, potato starch were also tried as superdisintegrants 8,9. But less or no works were reported using tapioca starch as superdisintegrant, a natural excipient which is mostly available in various parts of the world, having nutritional values, cost effective 10,11. In the present study an attempt was made to introduce tapioca starch, a natural excipient as superdisintegrant in the preparation of orodispersible tablets of paroxetine hydrochloride by direct compression and evaluate for its activity. The disintegrant action of tapioca starch was also compared with synthetic superdisintegrants like crospovidone, sodium starch glycolate. The present study also involved in evaluating effect of diluents like dicalcium phosphate, D- mannitol on tapioca starch activity. The results of the present investigation were reported in the following sections of this paper. MATERIALS AND METHODS Materials: Paroxetine hydrochloride was a gift sample from Aurobindo Pharma Limited. Tapioca starch was a gift sample from Life line formulations, Vijayawada. Crospovidone, sodium starch 37

3 Absorbance at 292 nm Research Article CODEN: IJPRNK ISSN: glycolate, D-mannitol, dicalcium phosphate, magnesium stearate, talc were procured from S.D. Fine chemicals Ltd, Mumbai. All other materials used were of analytical grade. Methods: Analytical method An UV-VIS spectrophotometric method was used for the estimation of Paroxetine hydrochloride in this work. A stock solution of Paroxetine HCl (1000µg/mL) was prepared in methanol and the absorbance of Paroxetine hydrochloride was measured at 292nm using Elico UV-VIS spectrophotometer SL 150. As the dissolution studies were carried out in 0 N HCl buffer 12, the standard concentrations were prepared using the same medium for dilution in the range of 2-10µg/mL of drug which obeyed Beer s law and calibration curve was constructed. The calibration data was given in table 1 and curve was shown in figure 1. Table 1 : Calibration curve data of Paroxetine Hydrochloride in 0N HCl buffer Concentration (μg/ml) Absorbance at 292nm y = x R² = Concentration(µg/mL) Figure 1 : Calibration curve of Paroxetine Hydrochloride in 0N HCl buffer 38

4 Compatibility Study Characterization by FTIR spectroscopy- Drug Excipient Compatibility was investigated by Fourier transform infrared (FTIR) spectroscopy. The samples for FTIR were prepared by KBr disc method. The infrared spectra of pure drug paroxetine hydrochloride, drug with excipients were collected over a spectral region from 4000 to 1000 cm -1. The characteristic peaks of drug were also found in optimized formula which indicated the absence of interactions between drug and excipients (table 2 and figure 2, 3). Table 2: FTIR spectral wave numbers and functional groups of Paroxetine Hydrochloride FUNCTIONAL GROUP PRESENT PEAK OBSERVED AT WAVE NUMBER(cm -1 ) Amine N-H Aromatic Bending C-O stretching C-N Aryl C=C Fig 2: FTIR Spectrum for Paroxetine Hydrochloride pure drug 39

5 Fig 3: FTIR Spectrum for Optimized formulation (F3) Preparation of ODTs of Paroxetine hydrochloride Direct compression method was used due to ease of manufacture, product stability and high efficiency, easy to scale up, cost effectiveness of the method. Compressed tablets of Paroxetine Hydrochloride using different superdisintegrants were prepared by direct compression method, as per formulae given in tables 3, 4. Accurately weighed quantities of drug (equivalent weight i.e., 44.4mg), super disintegrant were passed through sieve no #40 and remaining ingredients were added to the blend in a polybag and mixed homogeneously for 10 minutes. Sufficient quantities of diluent (Dicalcium phosphate/d-mannitol) was used to raise the total bulk of the tablet to a weight of 200mg each. The resulting powder blend was compressed on 8 station punching machine (ELITE mini press) using 7 mm round punches to the hardness of kg/cm 2. Table 3: Formulae of Orodispersible Tablets of Paroxetine Hydrochloride using DCP as diluent Formulation Ingredients Quantity of Ingredients(mg) F1 F2 F3 F4 F5 F6 F7 F8 F9 F10 F11 F12 Paroxetine HCl Tapioca starch

6 Crospovidone Sodium glycolite starch DCP Magnesium stearate Talc Saccharin q.s q.s q.s q.s q.s q.s q.s q.s q.s q.s q.s q.s Total Table 4: Formulae of Orodispersible Tablets of Paroxetine Hydrochloride using D-mannitol as diluent Formulation Quantity of Ingredients(mg) Ingredients F13 F14 F15 F16 F17 F18 F19 F20 F21 F22 F23 F24 Paroxetine HCl Tapioca starch Crospovidone Sodium glycolite starch D-mannitol Magnesium stearate Talc Saccharin q.s q.s q.s q.s q.s q.s q.s q.s q.s q.s q.s q.s Total EVALUATION Precompression parameters were carried out for powder blends like Angle of repose, Bulk density, Tapped density, Carr s index, Hausner s ratio as per pharmacopoeia methods 13. Postcompression parameters like thickness, hardness, friability, weight variation, drug content, wetting time, in-vitro disintegration time, in-vitro dissolution studies were carried out for compressed tablets as per pharmacopoeia methods

7 Thickness: Thickness was measured using Vernier calipers. Hardness: Hardness of tablets was measured using Monsanto hardness tester. Weight variation: Randomly selected twenty tablets were weighed collectively and individually using digital balance. Then the individual weight was compared with average weight. Friability: The Roche friability test apparatus was used to determine the friability of the tablets. Wetting time: Five circular tissue papers of 10cm diameter are placed in a petridish. Ten milliliters of water soluble dye solution is added to petridish. A tablet is carefully placed on the surface of the tissue paper. The time required for water to reach upper surface of the tablet is noted as the wetting time. In-vitro disintegration time: Six tablets were collected randomly and introduced each tablet into each tube of tablet disintegrating apparatus. Suspended the assembly in the beaker containing a medium of 900ml of water at temperature 37± 0.5 0C. Operated the disintegration apparatus and the time required for complete dispersion of a tablet was measured. In vitro Dissoluion studies: In vitro dissolution of orally disintegrated tablets of Paroxetine was studied in USP type-ii dissolution apparatus employing a paddle stirrer at 50 rpm. 900 ml of 0N HCl was used as dissolution medium. The temperature of dissolution medium was maintained at 37± 0.5 0C throughout the experiment. One tablet was used in each test. Samples of dissolution medium (5ml) were withdrawn by means of syringe fitted with pre-filter at known intervals of time and analyzed for drug release by measuring the absorbance at 292 nm. The volume withdrawn at each time interval was replaced with fresh quantity of dissolution medium. The dissolution studies were carried out in triplicate and the results were given in mean ± standard deviation values. 42

8 In-vitro release kinetics: Dissolution data of above formulations was fitted in Zero order, First order equations. Zero-Order Kinetics- Zero order as cumulative amount of drug released vs time, C = K 0 t Where K 0 is the zero-order rate constant expressed in units of concentration/time and t is the time in hours. A graph of concentration vs time would yield a straight line with a slope equal to K 0 and intercept the origin of the axis. First order kinetics- First order as log cumulative percentage of drug remaining vs time, l o g C = l o g C 0 K t / Where C 0 is the initial concentration of drug, K is the first order constant, and t is the time. RESULTS AND DISCUSSION Paroxetine orodispersible tablets were prepared by direct compression method according to the formulae showed in tables 3, 4. Evaluation parameters were performed in triplicate and the results were given in mean ±SD values. Pre compression parameters were performed inorder to evaluate the flow properties of powder blend. The results of various pre compression parameters were furnished in tables. The Angle of repose of the powder blend of drug and excipients was found to be (< 25 0 ) indicate excellent flow properties. Compressibility (%) index or Carr s index values ranged from 1 to 18.3 %. The Hausner s ratio values ranged from 114 to 196. The values of angle of repose, Hausner s ratio, Carr s index indicate the good flow property of powder blend of drug, excipients according to the specifications mentioned in USP. The results were furnished in tables 5, 6. 43

9 Table 5: Pre compression properties of formulations (F1-F12) containing DCP as Diluent Parameters Formulation code Bulk Density(ρ b ) gm/cc Tapped Density(ρ t ) gm/cc Angle of Repose(θ) Carr s index (%) Hausner s ratio F ± ± ± ±09 16±0.004 F ± ± ± ±5 139±0.003 F ± ± ± ±2 146±0.004 F ± ± ± ±07 135±0.005 F ± ± ± ±2 140±0.002 F ± ± ±9 17±06 133±0.001 F ± ± ±8 10.9±7 122±0.003 F ± ± ±3 15±08 114±0.004 F ± ± ±3 12±05 137±0.001 F ± ± ±0.51 1±3 114±0.004 F ± ± ± ±06 186±0.003 F ± ± ± ±4 155±0.001 Table 6: Pre compression properties of formulations (F13-F24) containing D-manntiol as Diluent Parameters Formulation code Bulk Density(ρ b ) gm/cc Tapped Density(ρ t ) gm/cc Angle Repose(θ) of Carr s index (%) Hausner s ratio F ± ± ± ± ±0.004 F ± ± ± ± ±0.003 F ± ± ± ± ±0.004 F ± ± ± ± ±0.004 F ± ± ±8 10.9± ±0.005 F ± ± ±1 14.8± ±0.003 F ± ± ± ± ±0.001 F ± ± ±1 15.9± ±

10 F ± ± ± ±0 183±0.003 F ± ± ± ± ±0.001 F ± ± ± ±0 153±0.004 F ± ± ± ± ±0.001 All the tablets were evaluated for post compression parameters like thickness, hardness, friability, weight variation, drug content, wetting time, in vitro disintegration time and the results were found to be within the pharmacopoeial limits. The results were furnished in tables 7, 8, 9, 10. Table 7: Post -compression properties of formulations (F1-F12) containing DCP as diluent Parameters Formulation code Thickness (mm) Hardness (Kg/cm 2 ) Weight variation (mg) Friability (%) Drug content (%) F1 35± ±0 200±03 49± 99±0 F2 38± ±05 200± ±0 99.8±0 F3 35± ±01 200± ± 99.9±0 F4 35± ±04 199± ±0 100±0 F5 30± ±04 200± ± 99.7±0 F6 37± ±03 199± ± 98.9±0 F7 3.33± ±05 200± ±0 98.9±0 F8 3.35± ±06 200± ± 99.9±0 F9 35± ±04 200± ± 99.8±0 F10 39± ±05 200± ±0 99.9±0 F11 32± ±03 200± ±0 99.8±0 F12 33± ±02 199± ± 98.9±0 Table 8: Post -compression properties of formulations (F13-F24) containing D-manntiol as diluent Formulation code Thickness (mm) Hardness (Kg/cm 2 ) Weight variation (mg) Friability (%) Drug content (%) F ±0.02 3± ±4 49 ± 99.9±0 F ± ± 200±04 68 ± 99.8±0 F15 3.9± ± ± ±0 98.9±0 45

11 F ± ± ± ± 100±0 F ± ±03 199± ±0 99.8± F ± ±04 200± ± 99.9±0 F ± ±0 200± ± 99.9±0 F20 35± ± ± ±0 99.9±0 F ±0.01 3± 200±2 53 ±0 99.9±0 F ± ± 200± ± 99.8±0 F ± ± ± ± 99.9±0 F ± ± ± ± 99.9±0.04 Hardness of all the tablets was maintained in the range of 3-3.5kg/cm 2. Thickness of the tablets was between mm. The results of friability test i.e., -0.5% and hardness indicated good mechanical resistance of all tablets. The drug content of almost all formulations was uniform and found to be in the range of %. Table 9: Post compression characteristics of the formulated ODT (F1-F12) containing DCP as diluent Formulation code Wetting Time (sec) Disintegration Time (sec) F1 18.5± ±2 F2 16.3± ±1 F3 15.5± ±1 F4 8.5±1 5.5±1 F5 20.±1 15±2 F6 14±2 8±1 F7 13±1 77±1 F8 10±1 56±2 F9 19± ±1 F10 14±2 10±1 F11 12±2 8.3±1 F12 10±1 6±2 46

12 Table 10: Post compression characteristics of the formulated ODT (F13-F24) containing D- manntiol as diluent Formulation code Wetting Time(sec) Disintegration Time(sec) F13 27±1 24±1 F14 23±2 20±2 F15 20±1 17±1 F16 20±1 17±1 F17 15±1 10.9±1 F18 15±1 10.7±1 F19 15±1 10.4±2 F20 15±2 10±1 F ±1 30±2 F22 33±2 30±1 F ±1 26±1 F24 21±1 18±1 All the formulations showed less in vitro disintegration time <30 sec, these results satisfy the definition of ODT by USP&EP. Formulations containing mannitol took more time for wetting and in vitro disintegration compared to those containing DCP. The values of low wetting time indicate that these formulations disperse fastly when kept in the mouth. IN VITRO DISSOLUTION STUDIES: The in vitro dissolution studies were carried out and the results were furnished in table 11, 12 and shown in figures 4, 5, 6, 7, 8, 9. The drug release patterns of all tablets revealed that on increase in concentration of superdisintegrant the drug release also increased. The tablet prepared from tapioca starch (7.5%) as superdisintegrant, DCP as diluent showed drug release of 100% within 5min whereas formulations with 2.5%, 5%, 10% took 10min for maximum percent drug release. The tablets prepared using crospovidone, SSG in different strengths like 2.5%, 5%, 7.5%, 10% respectively with DCP as diluent showed maximum percent drug release in more than 5min. The tablets prepared from tapioca starch(2.5%, 5%), as superdisintegrant and D-mannitol as diluent took more than 10min for maximum percent drug release. The tablets prepared from tapioca starch(7.5%), as superdisintegrants and D-mannitol as diluent gave drug release of 98.5% in 10min. The drug release patterns of formulations with crospovidone as superdisintegrant and D-mannitol as diluent are almost similar i.e., maximum percent drug release in 10min. The formulation with SSG(10%) and D-mannitol took 10min for drug release 47

13 whereas other ratios took more than 10min for maximum percent drug release. Therefore among all formulation F3 containing 7.5% tapioca starch as superdisintegrant and DCP as diluent showed rapid disintegration, better drug release of 100% within 5min. Table 11: Cumulative percent drug release of Paroxetine HCL in formulations containing DCP as diluent Tim Cumulative percent drug release with MSD e (mi n) F1 F2 F3 F4 F5 F6 F7 F8 F9 F10 F11 F ± ± ± ± ± 20.04± ± ± ± 11.93± ± 338± ± ± ± ± 20.47± 28.08± ± 51.79± 13.31± 20.47± 25.9± ± ± ± ± ± 47.08± 56.89± ± 88.01± 153± 36.57± 59.77± ± ± ± ± ± 90.8± ± 100± ± 558± ± ± ± ± ± ± ± ± 88.94± 96.89± ± ± 59.53± 71.45± ± ± 892± 95.04± Table 12: Cumulative percent drug release of Paroxetine HCL in formulations containing D- mannitol as diluent Time Cumulative percent drug release with MSD (min ) F13 F14 F15 F16 F17 F18 F19 F20 F21 F22 F23 F ± ± ±0 46± ± ±0 455± ±0 248± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0 72± ±0 984± ± ± ± ± ± ±0 1 78± ± ± ± ± ±0 44± ± ±0 933± ± ± ±0 84.8± ± ± ± ±0 927± ±0 981± ± ± ±0 48

14 Cumulative percentage drug release Cumulative percentage drug release Cumulative percentage drug release Research Article CODEN: IJPRNK ISSN: Time(min) F1 F2 F3 F4 Figure 4: Drug release profile of tablets containing tapioca starch as superdisintegrant and DCP as diluent Time(minutes) F5 F6 F7 F8 Figure 5: Drug release profile of tablets containing Crospovidone as superdisintegrant and DCP as diluent F9 F10 F11 F12 Time(minutes) 49

15 Cumulative percentage drug release Cumulative percentage drug release Research Article CODEN: IJPRNK ISSN: Figure 6: Drug release profile of tablets containing sodium starch glycolate as superdisintegrant and DCP as diluent F1 3 F1 4 Time(minutes) Figure 7: Drug release profile of tablets containing tapioca starch as superdisintegrant and D- mannitol as diluent F17 F18 F19 F20 Time(minutes) Figure 8: Drug release profile of tablets containing Crospovidone as superdisintegrant and D- mannitol as diluent 50

16 Cumulative percent drug release Research Article CODEN: IJPRNK ISSN: Time(minutes) F21 F22 F23 F24 Figure 9: Drug release profile of tablets containing sodium starch glycolate as superdisintegrant and D-mannitol as diluent IN VITRO RELEASE KINETICS: The in vitro drug release data was fitted into different kinetic models like zero order, first order and regression values were furnished in tables 13,14. The results revealed that correlation coefficient values of first order were better compared to zero order for almost all formulations. The first order plots of formulations showed fair linearity, with regression (R 2 ) values between The first order plot of F3 formulation showed fair linearity indicated by regression value R 2 = Thus all the formulations were found to follow first order kinetics. Table 13: Different kinetic models of Paroxetine HCl ODT s ( F1-F12) FORMULATION CODE ZERO ORDER FIRST ORDER R 2 R 2 F F F F

17 F F F F F F F F Table 14: Different kinetic models of Paroxetine HCl ODT s (F13-F24) FORMULATION CODE ZERO ORDER FIRST ORDER R 2 R 2 F F F F F F F F F F

18 F F CONCLUSION: The Paroxetine orodispersible tablets were successfully prepared. The optimized formulation was F3. The proposed method of formulation was found to possess reproducible characteristics in dispersion time and dissolution time. The tapioca starch was successfully used as superdisintegrant. REFERENCES: 1. Makino T, Yamada M. and Kikuta: J. Fast dissolving tablet and its production, 1993;European Patent A2. 2. Orodispersible Tablets, European Pharmacopeia, Version 6.5, Guidance for Industry on Orally Disintegrating Tablets US Department of Health and human Services, Food and Drug Administration, CDER, December Potter WZ and Hollister LE: Antidepressant agents Basic & Clinical Pharmacology, 9th edition, New York, USA, B. G. Katzung, Ed., McGraw Hill, Katzman MA:"Current considerations in the treatment of generalized anxiety disorder",(2009); CNS Drugs 23 (2): Sweetman SC. Ed., Martindale: The Complete Drug Reference, Pharmaceutical Press, London, UK, 2009; Vol-1 36th edition: p Navarro V. Improving medication compliance in patients with depression: use of orodispersible tablets. 8. Arun raj. R et al: comparative evaluation of potato starch and banana powder as disintegrating agents in aceclofenac tablets formulation. International Journal of Pharmacy and Pharmaceutical Sciences,2013; Vol 5, Issue Nattawat Nattapulwat, Narumol Purkkao, Ornamphai Suwithayapanth: Evaluation of Native and Carboxymethyl Yam (Dioscorea esculenta) Starches as Tablet Disintegrants. Silpakorn University Science and Technology Journal 2008, 2(2),

19 10. Mark Albano Avani F. Amin Tejal J.Shah, Reena Dua and Renuka Mishra. Superdisintegrants: An economical alternative. Pharmafocusasia Tapioca starch; Quality starch and chemicals (India) Pvt.Ltd. 12. Buffer Solutions, USP 30, NF 25 Asian edition, Rockville, MD: united state pharmacopoeial convention Inc; 2007, The united state pharmacopoeia, USP 30-NF 25 Asian edition, Rockville, MD: united state pharmacopoeial convention lnc; 2007, Lachman and Lieberman: The Theory and Practice of Industrial Pharmacy, 3 rd edition;

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD Int. J. Chem. Sci.: 6(3), 2008, 1270-1275 FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD K. P. R. CHOWDARY, P. TRIPURA SUNDARI and K. SURYA

More information

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012 STUDIES ON EFFECT OF SUPERDISINTEGRANTS ON ETORICOXIB TABLET FORMULATIONS Chowdary K. P. R 1, Venugopal. K *2 1 College of Pharmaceutical Sciences, Andhra University, Vishakapattanam. 2 * Nirmala college

More information

Formulation and evaluation of immediate release salbutamol sulphate

Formulation and evaluation of immediate release salbutamol sulphate 5 Formulation, optimization and evaluation of immediate release layer of salbutamol sulphate Salbutamol is moderately selective beta (2)-receptor agonist similar in structure to terbutaline and widely

More information

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium Available online on www.ijddt.com International Journal of Drug Delivery Technology 214; (3); 98-13 Research Article ISSN: 97 441 Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast

More information

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS Int. J. Chem. Sci.: 10(4), 2012, 1934-1942 ISSN 0972-768X www.sadgurupublications.com STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS K. VENUGOPAL * and K. P. R. CHOWDARY a Nirmala College

More information

Formulation and evaluation of oro-dispersible tablets of lafutidine

Formulation and evaluation of oro-dispersible tablets of lafutidine Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):226-235 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS Int. J. Chem. Sci.: 7(4), 2009, 2555-2560 FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS HINDUSTAN ABDUL AHAD *, B. PRADEEP KUMAR, C.

More information

Optimization of valsartan tablet formulation by 2 3 factorial design

Optimization of valsartan tablet formulation by 2 3 factorial design Research Article ISSN: 0974-6943 K. P. R. Chowdary et al. / Journal of Pharmacy Research 2014,8(9, Available online through http://jprsolutions.info Optimization of valsartan tablet formulation by 2 3

More information

Int. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN:

Int. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN: International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2014; 4(1):47-51 Research Article FORMULATION AND EVALUATION

More information

FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING AGENTS

FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING AGENTS Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Suppl 1, 2012 Research Article FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING

More information

Formulation and evaluation of sublingual tablets of lisinopril

Formulation and evaluation of sublingual tablets of lisinopril Journal of GROVER Scientific & Industrial AGARWAL: Research FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF LISINOPRIL Vol. 71, June 2012, pp. 413-417 413 Formulation and evaluation of sublingual tablets

More information

Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants

Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants ISSN: 2231-3354 Received on: 13-11-2011 Revised on: 18:11:2011 Accepted on: 22-11-2011 Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants Leela

More information

Design and development of fast Melting Tablets of Terbutaline Sulphate

Design and development of fast Melting Tablets of Terbutaline Sulphate Design and development of fast Melting Tablets of Terbutaline Sulphate Mathew T and Agrawal S Swami Vivekanand College of Pharmacy, Khandwa Road, Indore (MP), INDIA Available online at: www.isca.in (Received

More information

Formulation and Development of Sustained Release Tablets of Valsartan Sodium

Formulation and Development of Sustained Release Tablets of Valsartan Sodium INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article Formulation and Development of Sustained Release Tablets of Valsartan Sodium G. Sandeep * and A. Navya Department of

More information

DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS

DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Chinmaya Keshari Sahoo* 1, Tanmaya Keshari Sahoo 2 and

More information

PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE VEHICLE IN TABLET FORMULATIONS

PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE VEHICLE IN TABLET FORMULATIONS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE

More information

Optimization of Atenolol Core Tablet CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS

Optimization of Atenolol Core Tablet CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS 5.1. AIM OF THE STUDY The pulsatile type press coated colon targeted atenolol tablet release drug after 6 hr lag time. The compression coated

More information

Pavan K et al IJARPB: 2013, 3(2), ISSN: Available online on Research Article

Pavan K et al IJARPB: 2013, 3(2), ISSN: Available online on  Research Article Available online on www.ijarpb.com Research Article Received on 15/01/2013; Revised on 23/01/2013; Accepted on 27/01/2013; Fast Dissolving Tablets Of Pioglitazone Hydrochloride By Use Of Various Superdisintegrants

More information

Karnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS:

Karnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS: 335 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 4(6): November-December 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY

More information

Formulation and Evaluation

Formulation and Evaluation Chapter-5 Formulation and Evaluation 5.1 OBJECTIVE After successful taste masking and solubility enhancement of drugs in preliminary studies, by using Mannitol Solid Dispersion, next step includes the

More information

Design and In-vitro Evaluation of Silymarin Bilayer Tablets

Design and In-vitro Evaluation of Silymarin Bilayer Tablets CODEN (USA)-IJPRUR, e-issn: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Original Article Design and In-vitro Evaluation of Silymarin

More information

A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac

A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac Asian Journal of Chemistry Vol. 22, No. 6 (2010), 4239-4244 A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac K.P.R. CHOWDARY*

More information

Formulation and Evaluation of Glicazide Mouth Dissolving Tablets

Formulation and Evaluation of Glicazide Mouth Dissolving Tablets Research Article Vishakha S. Hastak*, Yogyata S. Pathare, Kiran C. Mahajan Department of Pharmaceutics, Shree Chanakya Education Society's Indira college of Pharmacy, Tathawade, Pune, Maharashtra, India.

More information

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN

More information

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Volume: 2: Issue-3: July-Sept -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Ajaykumar Patil*, Ashish Pohane, Ramya Darbar, Sharanya Koutika, Alekhya

More information

Formulation and evaluation of fast dissolving tablet of aceclofenac

Formulation and evaluation of fast dissolving tablet of aceclofenac International Journal of Drug Delivery 2 (2010) 93-97 http://www.arjournals.org/ijdd.html Research article ISSN: 0975-0215 Formulation and evaluation of fast dissolving tablet of aceclofenac Sudhir Bhardwaj

More information

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011 ISSN: 223-7346 Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp -394-43, Oct -Dec 211 FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE

More information

FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES

FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES Research Article Deshmukh ND,, 2012; Volume 1(5): 364-378 ISSN: 2277-8713 FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES *N. D. DESHMUKH, R. R.

More information

Available Online through

Available Online through ISSN: 0975-766X Available Online through Research Article www.ijptonline.com FORMULATION DESIGN AND OPTIMIZATION OF MOUTH DISSOLVE TABLETS OF GLIPIZIDE R.Shireesh Kiran 1*, B.Chander Shekar 1, Sharadha

More information

Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets

Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets Pharmaceutics Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets Remya KS, Beena P, Bijesh PV, Sheeba A Nazareth College

More information

International Journal of Medicine and Pharmaceutical Research

International Journal of Medicine and Pharmaceutical Research International Journal of Medicine and Pharmaceutical Research Journal Home Page: www.pharmaresearchlibrary.com/ijmpr Research Article Open Access Formulation and Evaluation of Gastroretentive Floating

More information

INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CHEMICAL SCIENCES

INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CHEMICAL SCIENCES Research Article Formulation, Development and Evaluation of Fast Dissolving Tablet of Salbutamol Sulphate by Using Superdisintegrants of Various Concentrations Santosh K 1 *, Meenakshi B 2 and Jyoti M

More information

International Journal of Biopharmaceutics. Journal homepage:

International Journal of Biopharmaceutics. Journal homepage: 59 e- ISSN 0976-1047 Print ISSN 2229-7499 International Journal of Biopharmaceutics Journal homepage: www.ijbonline.com IJB FORMULATION AND EVALUATION OF PROMETHAZINE HCl FAST DISINTEGRATING SUBLINGUAL

More information

Formulation and evaluation of oral dispersible tablets of aripiprazole

Formulation and evaluation of oral dispersible tablets of aripiprazole IJPAR Vol.6 Issue 2 April - June -17 Journal Home page: ISSN:23-2831 Research article Open Access Formulation and evaluation of oral dispersible tablets of aripiprazole A.Madhusudhan Reddy*, P.Srinivasababu,

More information

B. Jayakar et. al. FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF CELECOXIB R. Margret Chandira, Shyam Sharma, Debjit Bhowmik, B.

B. Jayakar et. al. FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF CELECOXIB R. Margret Chandira, Shyam Sharma, Debjit Bhowmik, B. Page117 Online Available at www.thepharmaresearch.info THE PHARMA RESEARCH, A JOURNAL The Pharma Research (T. Ph. Res.), (2010), 4; 117-122. Published on- 15 Dec 2010 Copyright 2009 by Sudarshan Publication

More information

Formulation and Evaluation of Gastroretentive Dosage form of Ciprofloxacin Hydrochloride.

Formulation and Evaluation of Gastroretentive Dosage form of Ciprofloxacin Hydrochloride. Available online on www.ijcpr.com International Journal of Current Pharmaceutical Review and Research, 3(4), 105-109 Research Article ISSN: 0976-822X Formulation and Evaluation of Gastroretentive Dosage

More information

FAST DISPERSING TABLETS REVIEW Chetan V. Suryawanshi*, N. A. Gujrathi, B. R. Rane

FAST DISPERSING TABLETS REVIEW Chetan V. Suryawanshi*, N. A. Gujrathi, B. R. Rane Impact factor: 0.3397/ICV: 4.10 80 Pharma Science Monitor 5(2), Sup-1, Apr-Jun 2014 PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES Journal home page: http://www.pharmasm.com

More information

International Journal of Pharmacy

International Journal of Pharmacy International Journal of Pharmacy Journal Homepage: http://www.pharmascholars.com Research Article CODEN: IJPNL6 FORMULATION AND EVALUATION OF ZOLMITRIPTAN FAST DISSOLVING TABLET USING SYNTHETIC SUPERDISINTEGRANTS

More information

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES Int. J. Chem. Sci.: 10(1), 2012, 297-305 ISSN 0972-768X www.sadgurupublications.com FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES K. P.

More information

International Journal of Medicine and Pharmaceutical Research. International Journal of Medicine and Pharmaceutical Research

International Journal of Medicine and Pharmaceutical Research. International Journal of Medicine and Pharmaceutical Research B.V. Ramana, IJMPR, 2016, 4(5): 252-261 CODEN (USA): IJMPMW ISSN: 2321-2624 International Journal of Medicine and Pharmaceutical Research Journal Home Page: www.pharmaresearchlibrary.com/ijmpr Research

More information

CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR

CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR Efavirenz and ritonavir, two widely prescribed anti retroviral

More information

EFFECT OF SUPERDISINTEGRANTS ON RELEASE OF DOMPERIDONE FROM FAST DISSOLVING TABLETS

EFFECT OF SUPERDISINTEGRANTS ON RELEASE OF DOMPERIDONE FROM FAST DISSOLVING TABLETS ISSN: 22-7346 B. Sujatha et al. / JGTPS/ 5(3)-(2014) 1973 1978 (Research Article) Journal of Global Trends in Pharmaceutical Sciences Journal home page: www.jgtps.com EFFECT OF SUPERDISINTEGRANTS ON RELEASE

More information

Formulation and evaluation of intraorally fast dissolving tablet of olmesartan medoxomil

Formulation and evaluation of intraorally fast dissolving tablet of olmesartan medoxomil Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2013, 5 (1):232-237 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

FORMULATIO A D EVALUATIO OF ORO DISPERSIBLE TABLETS OF CLO AZEPAM BY DIRECT COMPRESSIO METHOD

FORMULATIO A D EVALUATIO OF ORO DISPERSIBLE TABLETS OF CLO AZEPAM BY DIRECT COMPRESSIO METHOD FORMULATIO A D EVALUATIO OF ORO DISPERSIBLE TABLETS OF CLO AZEPAM BY DIRECT COMPRESSIO METHOD THAKKAR HARDIK R*, A.SENTHIL, RAVIKUMAR, V.B. NARAYANA SWAMY Karavali College of Pharmacy, Mangalore-575028,

More information

INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES

INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES International Journal of Institutional Pharmacy and Life Sciences 6(2): March-April 2016 INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES Pharmaceutical Sciences Research Article!!! Received:

More information

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN Research Article

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY  ISSN Research Article INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 8407 Research Article FORMULATION AND EVALUATION OF IMMEDIATE RELEASE VENLAFAXINE HCL TABLETS: COMPARATIVE STUDY OF SUPER DISINTEGRANT

More information

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.1, No.4, pp 1381-1385, Oct-Dec 2009 FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS

More information

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums 1368 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue 1 April-June 211 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue

More information

Asian Journal of Research in Pharmaceutical Sciences and Biotechnology

Asian Journal of Research in Pharmaceutical Sciences and Biotechnology Research Article ISSN: 2349-7114 Asian Journal of Research in Pharmaceutical Sciences and Biotechnology Journal home page: www.ajrpsb.com FORMULATION, IN VITRO DRUG RELEASE AND STABILITY STUDIES OF CLOPIDOGREL

More information

FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE

FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE ISSN: 2395 1338 FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE B. Venkateswara Reddy *, K. Navaneetha Department of Pharmaceutics, St.Paul s College

More information

Formulation and evaluation of mouth dissolving tablets containing losartan potassium

Formulation and evaluation of mouth dissolving tablets containing losartan potassium Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (17):115-123 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

Available online through ISSN

Available online through  ISSN Research Article Available online through www.ijrap.net ISSN 2229-3566 FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS OF METOPROLOL TARTRATE BY DIRECT COMPRESSION USING SUPER DISINTEGRANTS A. Senthil*

More information

Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants

Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol. 3, No.3, pp 1119-1124, July-Sept 2011 Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with

More information

Volume: I: Issue-2: Aug-Oct ISSN NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE

Volume: I: Issue-2: Aug-Oct ISSN NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE Volume: I: Issue-2: Aug-Oct -2010 ISSN 0976-4550 NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE * Hindustan Abdul Ahad, Anuradha CM, Chitta Suresh

More information

A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS

A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS Research Article A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS K. P. R. Chowdary *, Tanniru Adinarayana, T. Vijay, Mercy. R. Prabhakhar

More information

Int. Res J Pharm. App Sci., 2013; 3(6):42-46 ISSN:

Int. Res J Pharm. App Sci., 2013; 3(6):42-46 ISSN: International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2013; 3(6):42-46 Research Article ENHANCEMENT OF SOLUBILITY

More information

FORMULATION DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLET OF TRAMADOL HYDROCHLORIDE

FORMULATION DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLET OF TRAMADOL HYDROCHLORIDE Vol 6, Suppl 3, 2013 ISSN - 0974-2441 Research Article FORMULATION DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLET OF TRAMADOL HYDROCHLORIDE ABSTRACT SONALI J. SHAH *, RUPA MAZUMDER Department of

More information

Formulation and Evaluation of Etoricoxib Oro Dispersable Tablets by Direct Compression Method

Formulation and Evaluation of Etoricoxib Oro Dispersable Tablets by Direct Compression Method IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-issn:2278-3008, p-issn:2319-7676. Volume 11, Issue 2 Ver. III (Mar.- Apr.2016), PP 64-70 www.iosrjournals.org Formulation and Evaluation of

More information

Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine

Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine Mayur V. Chinchore*, Sanjay P. Aher, Chetan P. Mahajan, Ghanshyam J. Yadav, Avish D. Maru Department of Pharmaceutics,

More information

Pharmacologyonline 2: (2011) ewsletter Mehul et al. FORMULATIO A D EVALUATIO OF ORODISPERSIBLE TABLETS OF PHE IRAMI E MALEATE

Pharmacologyonline 2: (2011) ewsletter Mehul et al. FORMULATIO A D EVALUATIO OF ORODISPERSIBLE TABLETS OF PHE IRAMI E MALEATE FORMULATIO A D EVALUATIO OF ORODISPERSIBLE TABLETS OF PHE IRAMI E MALEATE DAVE MEHUL *, A.SENTHIL, THAKKAR HARDIK R, RAVIKUMAR, LAD TEJAS Karavali College of Pharmacy, Mangalore-575028, Karnataka, India.

More information

International Journal of Innovative Pharmaceutical Sciences and Research

International Journal of Innovative Pharmaceutical Sciences and Research International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLETS OF ZOLMITRIPTAN 1 Jalendhar Nakka *, 2 M.Srujan Kumar, 3 Dr.K.V.Subrahmanyam

More information

Maisammaguda, Dulapally, Secundrabad.

Maisammaguda, Dulapally, Secundrabad. 121 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(6): November-December 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY

More information

Journal of Global Trends in Pharmaceutical Sciences. Journal home page:

Journal of Global Trends in Pharmaceutical Sciences. Journal home page: ISSN: 2230-7346 G Sridhar Babu et al. / JGTPS/ 5(4)-(2014) 2085-2092 (Research Article) Journal of Global Trends in Pharmaceutical Sciences Journal home page: www.jgtps.com FORMULATION AND IN-VITRO CHARACTERIZATION

More information

FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS

FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS G. Subba Rao

More information

Formulation and Evaluation of Mouth Dissolving Sublingual Tablets of Cimetidine to Treat Abdominal Cramps

Formulation and Evaluation of Mouth Dissolving Sublingual Tablets of Cimetidine to Treat Abdominal Cramps International Journal of Pharmaceutical Science Invention ISSN (Online): 2319 6718, ISSN (Print): 2319 670X Volume 3 Issue 9 September 2014 PP.41-46 Formulation and Evaluation of Mouth Dissolving Sublingual

More information

International Journal of Pharmacology and Pharmaceutical Sciences 2016; Vol: 3, Issue: 3, 14-18

International Journal of Pharmacology and Pharmaceutical Sciences 2016; Vol: 3, Issue: 3, 14-18 International Journal of Pharmacology and Pharmaceutical Sciences 2016; Vol: 3, Issue: 3, 14-18. Research Article ISSN: 2394-613X FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF PERINDOPRIL USING

More information

MEDAK DIST. ANDHRA PRADESH STATE, INDIA. Research Article RECEIVED ON ACCEPTED ON

MEDAK DIST. ANDHRA PRADESH STATE, INDIA. Research Article RECEIVED ON ACCEPTED ON Page67 Available Online through IJPBS Volume 1 Issue 2 APRIL- JUNE 2011 SIMPLE QUANTITATIVE METHOD DEVELOPMENT AND VALIDATION OF VALSARTAN IN PUREFORM AND PHARMACEUTICAL DOSAGE FORMS BYUV SPECTROSCOPY

More information

Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)

Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online) Design and development of Metformin hydrochloride Tried sustained release tablets Venkateswara Rao T 1 *, Bhadramma N 1, Raghukiran CVS 2 and Madubabu K 3 Bapatla College of Pharmacy, Bapatla, Guntur-522101

More information

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Research Journal of Pharmaceutical, Biological and Chemical Sciences Research Journal of Pharmaceutical, Biological and Chemical Sciences Development and characterisation of oral fast dissolving tablet of nifedipine using camphor as a subliming material Shinde Anilkumar

More information

Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets

Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets M. Sunitha Reddy 1, B. Sharath Reddy 1, S. Muhammed Fazal Ul Haq 1 Centre of Pharmaceutical Sciences, Jawaharlal Nehru Technological

More information

The purpose of the present investigation was to design a formulation of orodispersible tablets of Etoricoxib by adopting

The purpose of the present investigation was to design a formulation of orodispersible tablets of Etoricoxib by adopting Research ARTICLE Formulation design and optimization of orodispersible tablets of etoricoxib by response surface methodology S R Shahi, G R Agrawal, N V Shinde, S A Shaikh 1, S S Shaikh, A N Padalkar 3,

More information

Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch

Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch Abstract K.P.R. Chowdary et al. / International Journal of Pharma Sciences and Research (IJPSR) Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch K.P.R. Chowdary*,

More information

FORMULATION AND EVALUATION OF FAST DISPERSIBLE TABLETS OF CITALOPRAM HYDROBROMIDE

FORMULATION AND EVALUATION OF FAST DISPERSIBLE TABLETS OF CITALOPRAM HYDROBROMIDE Page1371 Indo American Journal of Pharmaceutical Research, 2013. ISSN NO: 2231-6876 Journal home page: http:///index.php/en/ INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH FORMULATION AND EVALUATION

More information

Received on: Accepted on:

Received on: Accepted on: ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com FORMULATION, EVALUATION AND OPTIMIZATION OF ORODISPERSIBLE TABLET CONTAINING ANTI-EMETIC DRUG Imran AM* 1, Sudhakar

More information

Formulation and Evaluation of Taste Masked Oro-dispersible Tablets of an Anti-HIV Drug

Formulation and Evaluation of Taste Masked Oro-dispersible Tablets of an Anti-HIV Drug Int. J. Pharm. Sci. Rev. Res., 5(), July August 08; Article No., Pages: 78 ISSN 097 044X Research Article Formulation and Evaluation of Taste Masked Orodispersible Tablets of an AntiHIV Drug Arifa Begum.

More information

FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE CONTAINING MULTICOMPONENT INCLUSION COMPLEX

FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE CONTAINING MULTICOMPONENT INCLUSION COMPLEX Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Issue 1, 2012 Research Article FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE

More information

Formulation and Optimization of Immediate Release Tablet of Sitagliptin Phosphate using Response Surface Methodology

Formulation and Optimization of Immediate Release Tablet of Sitagliptin Phosphate using Response Surface Methodology Formulation and Optimization of Immediate Release Tablet of Sitagliptin Phosphate using Response Surface Methodology Sunita Shakya Department of Pharmacy, Kathmandu University, Kavre, Nepal. Email: sunita95@gmail.com

More information

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF AMLODIPINE BESYLATE

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF AMLODIPINE BESYLATE INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF AMLODIPINE

More information

DESIGN AND EVALUATION OF COST EFFECTIVE ORODISPERSIBLE TABLETS OF DIETHYLCARBAMAZINE CITRATE BY EFFERVESCENT METHOD

DESIGN AND EVALUATION OF COST EFFECTIVE ORODISPERSIBLE TABLETS OF DIETHYLCARBAMAZINE CITRATE BY EFFERVESCENT METHOD Vol.1(6), 010, 58-64 DESIGN AND EVALUATION OF COST EFFECTIVE ORODISPERSIBLE TABLETS OF DIETHYLCARBAMAZINE CITRATE BY EFFERVESCENT METHOD P. V. SWAMY*, S. N. GADA, S. B. SHIRSAND, M. B. KINAGI AND H. SHILPA

More information

Journal of Global Trends in Pharmaceutical Sciences

Journal of Global Trends in Pharmaceutical Sciences An Elsevier Indexed Journal ISSN-2230-7346 Journal of Global Trends in Pharmaceutical Sciences FORMULATION AND CHARACTERIZATION OF ORAL DISINTEGRATING TABLETS OF VALSARTAN BY SUBLIMATION AND EFFERVESCENCE

More information

ISSN: CODEN Code: PIHNBQ ZDB-Number: IC Journal No: Vol. 2 No Online Available at

ISSN: CODEN Code: PIHNBQ ZDB-Number: IC Journal No: Vol. 2 No Online Available at Received: 2-01-201 Accepted: 09-0-201 ISSN: 2277-795 CODEN Code: PIHNBQ ZDB-Number: 208-2 IC Journal : 7725 Vol. 2. 2 201 Online Available at www.thepharmajournal.com THE PHARMA INNOVATION - JOURNAL Formulation

More information

M.Vijaya Laxmi et al., Asian Journal of Pharmaceutical Technology & Innovation, 03 (10); 2015; Research Article

M.Vijaya Laxmi et al., Asian Journal of Pharmaceutical Technology & Innovation, 03 (10); 2015; Research Article Asian Journal of Pharmaceutical Technology & Innovation ISSN: 2347-8810 Research Article Received on: 18-12-2014 Accepted on: 31-12-2014 Published on: 15-02-2015 Formulation and Evaluation of Rizatriptan

More information

Research Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form

Research Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form Research Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form Gowekar NM, Lawande YS*, Jadhav DP, Hase RS and Savita N. Gowekar Department

More information

The present manuscript describes simple, sensitive, rapid, accurate, precise and cost effective First derivative

The present manuscript describes simple, sensitive, rapid, accurate, precise and cost effective First derivative ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF

More information

World Journal of Pharmaceutical and Life Sciences WJPLS

World Journal of Pharmaceutical and Life Sciences WJPLS wjpls, 2019, Vol. 5, Issue 1, 63-70 Research Article ISSN 2454-2229 Parveen et al. WJPLS www.wjpls.org SJIF Impact Factor: 5.008 FORMULATION AND DEVELOPMENT OF ENALAPRIL MALEATE FAST DISSOLVING TABLETS

More information

COMPARATIVE IN VITRO EVALUATION OF COMMERCIALLY AVAILABLE PANTOPRAZOLE DELAYED RELEASE TABLETS

COMPARATIVE IN VITRO EVALUATION OF COMMERCIALLY AVAILABLE PANTOPRAZOLE DELAYED RELEASE TABLETS 343 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(4): July-August 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO

More information

Formulation and Evaluation of Amlodipine besylate orally disintegrating tablet

Formulation and Evaluation of Amlodipine besylate orally disintegrating tablet Indo American Journal of Pharmaceutical Research. 2011:2(1);146-12. ISSN NO. 2231-6876 Journal home page: http://www.iajpr.com/index.php/en/ INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH Formulation

More information

Global College of Pharmacy, Kahnpur Khui, Tehsil Anandpur Sahib, Distt.- Ropar, Punjab, India

Global College of Pharmacy, Kahnpur Khui, Tehsil Anandpur Sahib, Distt.- Ropar, Punjab, India IJPSR (2012), Vol. 3, Issue 09 (Research Article) Received on 19 May, 2012; received in revised form 25 June, 2012; accepted 27 August, 2012 IN-VITRO EVALUATION OF TWO MARKETED BRANDS OF PARACETAMOL TABLETS

More information

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 975-1491 Vol 4, Suppl 5, 212 FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE

More information

Asian Journal of Research in Biological and Pharmaceutical Sciences

Asian Journal of Research in Biological and Pharmaceutical Sciences Research Article ISSN: 2349 4492 Asian Journal of Research in Biological and Pharmaceutical Sciences Journal home page: www.ajrbps.com APPLICATION OF FACTORIAL DESIGN AND OPTIMIZATION OF GLIMEPIRIDE SUSTAINED

More information

Formulation and development of orodispersible tablet of Memantine HCl by sublimation approach

Formulation and development of orodispersible tablet of Memantine HCl by sublimation approach Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (1):354-360 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

International Journal of Innovative Pharmaceutical Sciences and Research

International Journal of Innovative Pharmaceutical Sciences and Research International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION DESIGN OPTIMISATION EVALUATION OF ROPINIROLE HYDROCHLORIDE SUBLINGUAL FAST DISSOLVING TABLETS 1 G.Vikramadhitya

More information

Formulation and evaluation of Orodispersible tablets to enhance dissolution rate of Lamotrigine by using Solid Dispersion Technique

Formulation and evaluation of Orodispersible tablets to enhance dissolution rate of Lamotrigine by using Solid Dispersion Technique 35 Formulation and evaluation of Orodispersible tablets to enhance dissolution rate of Lamotrigine by using Solid Dispersion Technique Bhumi B. Patel 1 *, Chainesh N. Shah 2, Rumit M. Shah 3 1 Department

More information

IJRPC 2014, 4(2), Vinod Kumar et al. ISSN: INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY

IJRPC 2014, 4(2), Vinod Kumar et al. ISSN: INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY IJRPC 2014, 4(2), 415422 Vinod Kumar et al. ISSN: 2231 2781 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FACTORIAL STUDY ON THE EVALUATION

More information

DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG

DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG M Seth *, DS Goswami,

More information

7. SUMMARY, CONCLUSION AND RECOMMENDATIONS

7. SUMMARY, CONCLUSION AND RECOMMENDATIONS 211 7. SUMMARY, CONCLUSION AND RECOMMENDATIONS Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability

More information

PREPARATION AND INVITRO EVALUATION OF RABEPRAZOLE SODIUM DELAYED RELEASE ENTERIC COATED TABLETS

PREPARATION AND INVITRO EVALUATION OF RABEPRAZOLE SODIUM DELAYED RELEASE ENTERIC COATED TABLETS Page1000 Indo American Journal of Pharmaceutical Research, 2014 ISSN NO: 2231-6876 Journal home page: http:///index.php/en/ INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH PREPARATION AND INVITRO EVALUATION

More information

International Journal of Pharma and Bio Sciences NOVEL CO-PROCESSED SUPERDISINTEGRANTS IN THE DESIGN OF FAST DISSOLVING TABLETS

International Journal of Pharma and Bio Sciences NOVEL CO-PROCESSED SUPERDISINTEGRANTS IN THE DESIGN OF FAST DISSOLVING TABLETS S.B.Shirsand*, R. G. Ramani, P.V.Swamy Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Sedam Road, Gulbarga-585 105, India * Correspondence Address shirsand@rediffmail.com

More information

Available online Research Article

Available online   Research Article Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 26, 8(2):7-7 Research Article ISSN : 975-7384 CODEN(USA) : JCPRC5 Optimization of directly compressible mixtures of microcrystalline

More information

FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS

FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 974-434 Vol.2, No.1, pp 341-347, Jan-Mar 1 FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS Kothawade S. N. 1 *, Kadam

More information