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7 Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis

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9 Vitamin K2 is an essential fat-soluble vitamin with proven bone and heart health benefits deficient in western diets

10 Vitamin K2 MK-7 Menaquinone-7 Vitamin K1 Phylloquinone Vitamin K2 MK-4 Menaquinone-4

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12 Calcium Too much calcium leads to blockages & hardening - constricting blood flow & oxygen delivery Bones need calcium for growth - providing framework for muscles & protection

13 Calcium alone is insufficient for bone building Vitamin D3 absorbs calcium into the blood stream Vitamin K2 activates the proteins that binds calcium into bone

14 Change in bone mineral content (BMC) and bone mineral density (BMD) during the 3-year-intervention

15 Activated MGP reduces arterial calcification Vitamin K2 deficiency may lead to calcium depositions in vessels.

16 MK-7 reduces the level of inactive MGP (ucmgp) over three years (Knapen et al., 2015) Changes in arterial stiffness index by MK-7 over a 3-year intake (Knapen et al., 2015)

17 VITAMIN K2 MK-7 SUPPORTS STRONG BONES FOR ALL CONSUMER SEGMENTS High dose K needed for growing bones Adjust high dose K to reduce bone loss

18 8 weeks of supplementation of MK-7 gave a 12% significant increase in maximal cardiac output. McFarlin, B.K., A.L. Henning, and A.S. Venable, Oral Consumption of Vitamin K2 for 8 Weeks Associated With Increased Maximal Cardiac Output During Exercise. Altern Ther Health Med, 2017.

19 CHILDREN & ADOLESCENTS EARLY ADULTHOOD AGE ACTIVE LIFESTYLES AGE SENIOR YEARS Bone Heart Some degree of arterial calcification may be common, even having been demonstrated in otherwise healthy adolescents (Newman 2008)

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21 Average vitamin content in a balanced diet Minimum recommended intake 75µg Amount of Vitamin K1 and K2 in Various Food (in μg / 100g food) Meat Fish Milk Cheese Butter Margarine Green Vegetables Natto Dish Fruit

22 Vitamin K1 (phylloquinone) Vitamin K2 (menaquinones) Vitamin K1 Phylloquinone Vitamin K2 MK-4 Menaquinone-4 K2 MK-7 Menaquinone-7 K2 MK-14 MK-7 Highlighted

23 Differences Vitamin K1 and K2 Vitamin K serum (mg/ml) Time after ingestion (24h) Schurgers et al 2007 Serum Half-Lifes

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25 Moving from niche to mass Food Today Mass Market MLM Internet Health Retail

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27 Vitamin K2 MK-7 is particularly susceptible to degradation in combination with minerals. A technical solution was needed.

28 2014 Vitamin K2 MK-7 with Calcium carbonate Vitamin K2 MK-7 with Magnesium oxide Delta Encapsulated K2 MK-7 Stability 41% Calcium + K2 Products CONTAINED NO K2 AT ALL (ZERO). 80% Calcium + K 2 WERE LESS THAN LABEL CLAIM.

29 3 months recovery DELTA vs unprotected/fermented K2 100% K2VITAL DELTA K2VITAL DELTA K2VITAL DELTA K2VITAL DELTA Fermented powder Fermented powder Fermented powder Fermented powder Calcium L-Arginine Magnesium Krill Oil

30 Percent Label Claim: Unprotected/Natural Fermented K2 plus Calcium or Magnesium Finished Products Tested Products n = 94 (46 Tested Products < 24%) Percent Label Claim: Unprotected/Natural Fermented K2 MK-7 Alone or in Non-mineral Formulations Tested Products n = 16 Kappa Bioscience Market Study: K2 Stability 2017 Protected, microencapsulated K2VITAL DELTA, or separation of ingredients via capsuling technology, ensures promises to consumers

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33 Kappa s organic synthesis starts with flowers Double-coated Beadlet with two water-dispersible coatings Menaquinone-7 K2VITAL all-trans MK-7 (99.8%) Highest purity (USP grade) Highest bioavailability Best cost-in-use K2VITAL first microencapsulated K2 MK-7 Stable with minerals and alkaline ingredients 3 years stability data in finished formulations Critical for content compliance

34 Vitamin K2 is an essential micro-nutrient Benefits in bone and heart health well-established: 19 published studies Market growth is exploding: K2 will be the next D3; concepts confirm appeal K2VITAL has significant advantages in stability, purity and price Microencapsulated DELTA stable when combined with calcium and magnesium Synthetic patented process ensures highest quality and low cost K2VITAL fills a gap in YOUR nutrient portfolio

35 OPTIMAL CALCIUM FUNCTION

36 Safe Iberoamericana S.A. de C.V. José María Rico Col. Del Valle Ciudad de México México. C.P Jorge Cabeiro S. Tel. (+5255) Fax (+5255) Kappa Bioscience AS Silurveien 2 Building B 0380 Oslo Norway Sales and Marketing Kappa Ingredients GmbH Deichstraße Hamburg Germany