Advances in. Nutritional Research. Volume 10. Immunological Properties of Milk

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1 Advances in Nutritional Research Volume 10 Immunological Properties of Milk

2 Advances in Nutritional Research A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

3 Advances in Nutritional Research Volume 10 Immunological Properties of Milk Edited by Bill Woodward and Harold H. Draper University of Guelph Guelph, Ontario, Canada Kluwer Academic / Plenum Publishers New York, Boston, Dordrecht, London, Moscow

4 The Library of Congress eataloged the first volume of this title as follows: Advanees in nutritional researeh, v. 1- New York, Plenum Press, e v. ill. 24 em. Key title: Advanees in nutritional researeh. ISSN Nutrition-Yearbooks QP14l.AIA ' ISBN ISBN (ebook) DOI / l Springer Seienee+Business Media New York Originally published by Kluwer / Plenum Publishers, New York in 2001 Softeover reprint of the hardeover Ist edition A c.i.p. record for this book is available from the Library of Congress Ali rights reserved No part of this book may be reproduced, stored in a retrieval system, Of transmitted in any form or by any means, electronic, mechanical, photocopying, microfilrning, recording, or otherwise, without written permission from the Publisher

5 Contributors Mohsen Araghi-Niknam, Arizona Prevention Center, P.O. Box ,1501 N. Campbell Avenue, University of Arizona, Tucson, AZ Patrick F. W. Chien, Department of Obstetrics and Gynaecology, University of Dundee, Ninewells Hospital, Dundee, Scotland DDl 9SY Roberta Chierici, Department of Clinical and Experimental Medicine, Section of Neonatology, Arcispedale "S. Anna", Ferrara, Italy Thomas G. Cleary, Department of Pediatrics, Infectious Disease Division, University of Texas-Houston Health Science Center, 6431 Fannin Street, JFB 1.739, Houston, TX Mark D. Cregan, Department of Biochemistry, The University of Western Australia, Nedlands, Western Australia 6907, Australia U. I. Dahlgren, Department of Clinical Immunology, Goteborg University, Guldhedsgatan 10, S Goteborg, Sweden Catherine M. Fetherston, Department of Biochemistry, The University of Western Australia, Nedlands, Western Australia 6907, Australia Suzanne M. Filteau, Centre for International Child Health, Institute of Child Health, 30 Guilford Street, London WCIN IEH, England Armond S. Goldman, The Division ofimmunology/allergylrheumatology, The Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX Lars A. Hanson, Department of Clinical Immunology, Goteborg University, Guldhedsgatan 10, S Goteborg, Sweden Peter E. Hartmann, Department of Biochemistry, The University of Western Australia, Nedlands, Western Australia 6907, Australia v

6 vi Contributors Saeed Hosseini, Arizona Prevention Center, P.O. Box , 1501 N. Campbell Avenue, University of Arizona, Tucson, AZ Peter W. Howie, Department of Obstetrics and Gynaecology, University of Dundee, Ninewells Hospital, Dundee, Scotland DDI 9SY Alan J. Husband, Department of Veterinary Anatomy and Pathology, The University of Sydney, NSW 2006, Australia Paula Inserra, Arizona Prevention Center, P.O. Box , 1501 N. Campbell Avenue, University of Arizona, Tucson, AZ Charles E. Isaacs, Department of Developmental Biochemistry, Institute for Basic Research, 1050 Forest Hill Road, Staten Island, NY Shannon L. Kelleher, Department of Nutrition, University of California, Davis, CA Margaret A. Keller, Harbor-UCLA Medical Center, Torrance, CA Ann M. Kosloske, Departments of Surgery and Pediatrics, Texas Tech University School of Medicine, Lubbock, TX Ruth A. Lawrence, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY Chee Seong Lee, Department of Veterinary Science, The University of Melbourne, Parkville, Vic 3052, Australia 80 L6nnerdal, Department of Nutrition, University of California, Davis, CA Leon R. Mitoulas, Department of Biochemistry, The University of Western Australia, Nedlands, Western Australia 6907, Australia Marita Noguera-Obenza, Department of Pediatrics, Infectious Disease Division, University of Texas-Houston Health Science Center, 6431 Fannin Street, JFB 1.739, Houston, TX Gerd Riedel-Caspari, PlantaVet, Postfach 1339, Finkenweg 13, D Bad Waldsee, Germany H. Schroten, University Children's Hospital, Moorenstrasse 5, Dusseldorf, Germany E. Richard Stiehm, Department of Pediatrics, UCLA Children's Hospital, Los Angleles, CA E. Telemo, Department of Clinical Immunology, G6teborg University, Guldhedsgatan 10, S-4l3 46 G6teborg, Sweden

7 Contributors vii Ian R. Tizard, Department of Veterinary Pathobiology, Texas A&M University, College Station, TX Ronald R. Watson, Arizona Prevention Center, P.O. Box , 1501 N. Campbell Avenue, University of Arizona, Tucson, AZ Chun W Wong, Department of Animal Science, University of New England, Arrnidale, NSW 2351, Australia

8 Contents of Earlier Volumes Volume 1: Role of Vitamin K in the Synthesis of Clotting Factors, J W. Suttie The Metabolic Significance of Dietary Chromium, Cihad T. Giirston The Significance of Folate Binding Proteins in Folate Metabolism, Samuel Waxman, Carol Schreiber; and Mitchell Rubinoff Folate Deficiency in Humans, Neville Colman Metabolic and Nutritional Consequences of Infection, William R. Beisel Regulation of Protein Intake by Plasma Amino Acids, Gerald Harvey Anderson Metabolic Disorders of Copper Metabolism, Gary W. Evans The Role of Nutritional Factors in Free-Radical Reactions, Lloyd A. Witting The Role of Copper and Zinc in Cholesterol Metabolism, Leslie M. Klevay Relationship between Nutrition and Aging, Charles H. Barrows and Gertrude S. Kokkonen Amino Acid Nutrition Research of the Chick, David H. Baker Volume 2: Regulation of Energy Metabolism in Ruminants, Ransom Leland Baldwin and Nathan Elbert Smith Influence of Nutrition on Metabolism of Carcinogens, T. Colin Campbell Influence of Nutritional Status on Susceptibility to Infection, R. K. Chandra Nutrition and Osteoporosis, Harold H. Draper and R. Raines Bell Metabolism of Hydrogen Selenide and Methylated Selenides, Howard E. Ganther Microbial Factors and Nutrition in Carcinogenesis, Barry R. Goldin and Sherwood L Gorbach Nutrition and Neural Lipids, Patricia V. Johnson Atherosclerosis and Nutrition, David Krichevsky Nutrition and Colon Cancer, Bandaru S. Reddy Trace Elements and Carcinogenesis, G. N. Schrauzer Volume 3: Lipid Metabolism and Ischemic Heart Disease in Greenland Eskimos, Hans Olaf Bang and J rn Dyerberg Trace Element Deficiencies in Man, Clare E. Casey and K. Michael Hambidge Current Concepts of Intravenous Hyperalimentation, Mervyn Deitel and Linda D. Macdonald Dietary Influences on Prostaglandin Synthesis, Claudio Galli Stable Isotope Methods for Bioavailability Assessment of Dietary Minerals in Humans, Morteza Janghorbani and Vernon R. Young Evidence of the Essentiality of Arsenic, Nickel, and Vanadium and Their Possible Nutritional Significance, Forrest I:. Nielsen Protein in the Nutrition of the Preterm Infant: Biochemical and Nutritional Considerations, Niels C. R. Riiihii The Metabolism of Long-Chain Monoenoic Fatty Acids in Heart Muscle and Their Cardiopathogenic Implications, Frank D. Sauer and John K. G. Kramer The Biology of Taurine in Nutrition and Development, John A. Sturman and Kenneth C. Hayes Trichothecene Mycotoxins: Mycology, Chemistry, and Toxicology, Yoshio Veno Volume 4: Vitamin-Responsive Genetic Abnormalities, S. Harvey Mudd Vitamin D Binding Proteins, John G. Haddad, Jr. Vitamin D Compounds in Human and Bovine Milk, Bruce W. Hollis, Bernard A. Roos, and Phillip W. Lambert ix

9 x Contents of Earlier Volumes Dietary Protein, Metabolic Acidosis, and Calcium Intake, John T. Brosnan and Margaret E. Brosnan The Nutritional Significance, Metabolism, and Function of myo-inositol and Phosphatidylinositol in Health and Disease, Bruce J. Holub Neurobiology of Pyridoxine, Krishnamurti Dakshinamurti Camitine Biosynthesis: Nutritional Implications, Harry P. Broquist and Peggy R. Borum Insect Nutrition: A Comparative Perspective, W G. Friend and R. H. Dadd The Nutrient Requirements of Cultured Mammalian Cells, William J. Bettger and Ricahrd G. Ham Fatty Acid Metabolism in the Neonatal Ruminant, Raymond Clifford Noble and John Herbert Shand Volume 5: Nutritional Management of Hepatic Encephalopathy, Robert H. Bower and Josef E. Fischer Cellular Retinol- and Retinoic Acid-Binding Proteins, Frank Chytil and David E. Ong Nutrition and 3-Methylindole-Induced Lung Injury, James R. Carlson and Tammy M. Bray Platelets and Atherosclerosis, Kaj Anker J rgensen and J rn Dyerberg Nutritional Support of the Hospitalized Child, Russell J. Merritt, Frank R. Sinatra, and Gary A. Smith Nutrition of the Cancer Patient, J. W T. Dickerson The Interrelationships among Folate, Vitamin B 12, and Methionine Metabolism, Barry Shane and E. L. Robert Stokstad trans and Positional Isomers of Common Fatty Acids, Joyce L. Beare-Rogers Diet-Induced Thermogenesis, Nancy J. Rothwell and Michael J. Stock The Influence of Dietary Fatty Acid Composition on Lipogenesis, Gene R. Herzberg Volume 6: Evidence for Alternative Pathways of Methionine Catabolism, N. J. Benevenga The Immunostimulatory, Anti-Inflammatory and Anti-Allergic Properties of Ascorbate, Ronald Anderson Epidemiologic Studies on Vitamin A with Cancer, Curtis Mettlin Metabolic Bone Disease Associated with Total Parenteral Nutrition, Gordon L. Klein and Jack W Coburn Nutrition and Protein Turnover in Man, P. J. Reeds and P. J. Garlick Zinc Binding Ligands and Complexes in Zinc Metabolism, Bo LOnnderdal, Carl L. Keen, and Lucille S. Hurley The Clinical Implications of Dietary Fiber, David J. A. Jenkins and Alexandra L. Jenkins The Role of Selenium in Keshan Disease, Guangqi Yang, Junshi Chen, Zhimei Wen, Keyou Ge, Lianzhen Zhu, Xuecun Chen, and Xiaoshu Chen Sucrose-Isomaltose Malabsorption, E. Gudmand-H yer, P. A. Krasilnikoff, and H. Skovbjerg Nutrient Absorption in Gnotobiotic Animals, Giza Bruckner and JozseJ Szabo Volume 7: Food Allergy, David J. Pearson and Alison McKee The Dietary Management of Diabetes, H. C. R. Simpson and J. /. Mann Cognitive Effects of Nutritional Deficiency, Mark J. Rosenthal and James S. Goodwin Nutritional Assessment of Observed Nutrient Intake: An Interpretation of Recent Requirement Reports, G. H. Bearon The Role of Ethanol in the Etiology of Primary Liver Cancer, N. G. Misslbeck and T. C. Campbell Animal Models for the Study of Nutrition and Human Disease: Colon Cancer, Atherosclerosis, and Osteoporosis, R. P. Bird

10 Contents of Earlier Volumes xi Direct and Indirect Thennogenic Effects of Anorectic Drugs, David A. Levitsky and Barbara J. Strupp Role of Fennented Milk Products in Milk Intolerance and Other Clinical Conditions, D. Ramkishan Rao, S. R. Pulusani, and C. B. Chawan Metabolic Interactions of Selenium with Cadmium, Mercury, and Silver, P. D. Whanger Total Parenteral Nutrition in the Newborn: An Update, S. H. Zlotkin and V. A. Stallings Volume 8: The Transfer of Nutrients across the Perfused Human Placenta, Joseph Dancis Immunoenhancement in Wasting Protein-Energy Malnutrition: Assessment of Present Infonnation and Proposal of a New Concept, B. Woodward and S. M. Filteau The Role of Nutrition in the Prevention and Treatment of Hypertension, Pirjo Pierinen and Antti Aro Energy Metabolism of the Newborn Infant, Robin K. White and Henry S. Bayley Nutritional Assessment of the Hospitalized Patient, Paul M. Starker Nutritional Modulation of Oxygen Radical Pathology, Harold H. Draper Volume 9: The Gain and Loss of Bone in the Human Life Cycle, John F. Aloia Low Bone Mass in Past and Present Aboriginal Populations, Susan K. Pfeiffer and Richard A. Lazenby Bone Loss in Animals, H. H. Draper The Significance of Habitual Calcium Intake in the Pathogenesis of Peri- and Early Postmenopausal Bone Loss, E. C. H. van Beresteijn Osteoporosis in Japan: Factors Contributing to the Low Incidence of Hip Fracture, Takuo Fujita Osteoporosis in Asia, E. M. C. Lau and J. Woo Calcium and Osteoporosis?, D. M. Hegsted Ethnic and Genetic Differences in Susceptibility to Osteoporotic Fractures, John J. B. Anderson and William S. Pollitzer Suboptimal Vitamin D Status: A Risk Factor for Osteoporosis?, P. Lips Protein Intake and Calcium Homeostasis, Jane E. Kerstetter and Lindsay H. Allen The Effects of High Phosphorus Intake on Calcium Homeostasis, Mona S. Calvo The Effect of Sodium on Calcium Requirement, B. E. Christopher Nordin and Allan G. Need Fluoride in the Prevention and Treatment of Osteoporosis, Jukka A. Inkovaara Bone Mineral Content in Postmenopausal Vegetarians and Omnivores, Isabelle F. Hunt The Effect of Obesity on Postmenopausal Bone Loss and the Risk of Osteoporosis, Claude Ribot, Florence Tremollieres, and Jean-Michel PouilLes Exercise and Bone Loss, Everett L. Smith, Catherine Gilligan, and Lorri J. Tommerup The Menstrual Cycle: Effects on Bone in Menopausal Women, Susan l. Barr and Jerilynn C. Prior

11 Preface This volume of Advances in Nutritional Research focuses on colostrum and milk as agents of defense against infection both for the suckling offspring and for the lactating mammary gland. The scope of the volume includes positive and negative influences of the consumption of mother's milk on the risk of infection, immunobiological roles of individual milk components, activities of milk and its components in promoting development of neonatal immunocompetence, the potential of milk and its components as therapeutic agents and as functional foods that support immune competence, and external influences that determine the immunological activity of milk. The volume is intended to provide a critical assessment of the limits of available information pertaining to humans and animals, together with authoritative comment regarding newer directions and unproven ideas. Part I provides a foundation for the volume. Readers unfamiliar with immunology will find, in Chapter 1, a selective outline of the anatomy and ontogeny of the mammalian immune system and of the types and regulation of immune defenses in mammals. Some emphasis is given to the place of the mammary gland within the common mucosal defense system, and to important species peculiarities in this regard. Chapter 2 is an authoritative and forwardlooking perspective on the development of knowledge pertaining to the immunobiology of milk as a fluid with both anti-infectious and anti-inflammatory roles. The chapter poses the provocative possibility of a tolerogenic role for milk. Thus, future research into this subject not only will address critical points of detail such as the identification of an increasingly diverse array of immunomodulatory, antiinflammatory and possibly tolerogenic agents in milk, but also will continue to revise understanding, at the most basic level, of the role of milk as an immunological link between generations. Chapter 3 then highlights the major immunological components that have been identified in milk and that are the subject of subsequent chapters in the volume. Part II focuses on the influence of the consumption of mother's milk on the risk of infection without regard for any particular immunological component of xiii

12 xiv Preface milk. Chapter 4 provides a systematic and critical analysis of epidemiological evidence regarding the impact of breast-feeding on the risk of major opportunistic infections in infancy. The review addresses infections of the gastrointestinal, respiratory and urinary tracts as well as infection with Haemophilus injiuenzae, a leading cause of bacterial meningitis in infants. Compelling evidence exists that breast-feeding protects against gastrointestinal infections in both industrialized and non-industrialized settings, and a reasonable evidence base also points to protective efficacy against respiratory infections in an industrialized setting. Many readers may be surprised by the dearth of quality evidence pertaining to the risk of respiratory, urinary tract and H. injluenzae infection in non-industrialized settings. Although milk undoubtedly confers anti-infectious benefits, it can also serve as a vehicle for the transmission of viral and bacterial pathogens to the suckling offspring. Evidence is evaluated in Chapter 5 with respect to the transmission of fourteen different pathogenic viruses through human milk. In addition, practical clinical recommendations specific to each organism are provided. As is pointed out subsequently in this volume (Chapter 19), the risk of transmitting infection through milk is an important reason that cross nursing is no longer recommended and that banked human donor milk should be pasteurized. Chapter 6 comprises a discussion of the epidemiology, clinical presentation and pathogenesis of neonatal necrotizing enterocolitis, a leading cause of infant mortality in some industrialized countries. Although the pathogenesis of this condition is poorly understood, an infectious component is suspected and breast-feeding remains the only proven preventive strategy. Chapter 7 provides much direct evidence that passive transfer of resistance to infection through colostrum and mature milk is essential to the offspring of domestic species and rodents. Compelling indirect evidence is also discussed in relation both to these species and to an impressive diversity of additional species, and derives from studies of placentation, intestinal absorption of intact immunoglobulins and the timing and mechanisms of gut closure. In addition, this chapter is a rich source of information describing the immunoglobulins and cellular components of milk in a plethora of non-human species. Finally, Chapter 8 illustrates the importance of milk for the protection of the mammary gland against infection throughout lactation. By demonstrating that knowledge of this role is much more advanced in relation to the bovine species than in relation to humans, the chapter presents a fascinating example of the impact of commercial and economic considerations in determining research priorities. Part III centers on individual immunological components of milk that appear to function in the passive transfer of defense against infection. The most widely recognized anti-infectious agent in milk is immunoglobulin and, in human milk, this is primarily secretory IgA. The main point of Chapter 9 is the significance ascribed to the immunoglobulin fraction of milk as reflected in efforts to use bovine colostrum and hyper-immune bovine milk as therapeutic agents in

13 Preface xv the management of human gastrointestinal infections. The specific immunoglobulin content of some preparations has been clearly implicated in their efficacy, but immunoglobulin has appeared irrelevant to the effectiveness of other preparations. Chapter 9 also briefly summarizes the more compelling evidence implicating breast milk IgA in the protection of infants against some enteric bacterial and viral pathogens as well as against some respiratory viruses. It is noteworthy that breast-milk IgA does not appear to confer passive protection against all viral agents of respiratory disease. Continuing this theme, Chapter 10 constitutes an in-depth critique of evidence implicating milk IgA in the protection of infants against bacterial diarrhea. The important point is made that evidence is not abundant to unequivocally relate breast milk antibody to the protection of a suckling infant against infection. Chapter 11 presents a description of the chemistry, biosynthesis and possible non-specific immunological actions of some high molecular weight milk glycoproteins (mucins). The emphasis ofthe chapter is on the human species, but laboratory and domestic species are discussed where information exists. Suggestive evidence implicates milk mucins as anti-infectious blocking agents, as prebiotics and as participants in the anti-inflammatory function of milk. However, direct evidence of an immunological role for these macromolecules is not yet available. Stronger and more extensive evidence points to lactoferrin as a non-specific anti-infectious agent, at least in human milk in which this protein is found in high concentration. Chapter 12 describes the substantial evidence that lactoferrin can exert anti-bacterial, anti-fungal and anti-viral effects in vitro. Direct evidence of a role as a milk-borne anti-infectious agent derives from studies demonstrating that oral doses of lactoferrin can protect laboratory rodents against enteric pathogens. Moreover, a prebiotic function favoring colonic Bifidobacteria is suggested through studies of rodents and infants. Additional non-specific defense against infection may be conferred by some of the lipids in milk, notably the medium-chain saturated and long-chain unsaturated fatty acids together with their monoglycerides that are released by digestive lipolysis. These components inactivate enveloped viruses and kill bacteria and protozoans in vitro, and a discussion of their potential as passive agents of anti-infectious defense for humans is found in Chapter 13. Finally, it is often overlooked that milk contains large numbers of lymphocytes, mononuclear phagocytes and neutrophils. Chapter 14 summarizes information regarding the numbers of these cellular elements in the colostrum and milk of humans and domestic animals. The chapter provides an assessment of the importance of milk leukocytes in protecting both the mammary gland and the suckling offspring. With regard to the latter, evidence remains only suggestive and is based primarily on a body of information describing immunological activities of milk leukocytes in vitro. Particularly intriguing possibilities relate to the transfer of cell-mediated immune sensitization from mother to offspring and the capacity of colostral and milk leukocytes to penetrate the intestinal epithelial barrier of the suckling neonate. In this connection, the

14 xvi Preface largely unsubstantiated concern persists that milk leukocytes can serve as vectors for the passive transfer of intracellular parasites. Part IV focuses on the immunomodulatory activities of milk. Chapter 15 summarizes evidence that consumption of mother's milk is important to the development of immune competence in infants and neonatal animals. This chapter and Chapter 16 then examine the evidence implicating particular colostral and milk components in this capacity. The anti-inflammatory action of milk appears critical to its immunomodulatory role, and a disperse literature implicates components such as lactoferrin and a number of cytokines, most notably transforming growth factor beta. Anti-idiotypic antibodies and nucleotides are also strongly implicated as exerting a direct immunomodulatory influence. Species differences are likely, e.g., as indicated by the low levels of lactoferrin and nucleotides in bovine milk relative to that of humans. In addition, an indirect prebiotic effect may contribute to the immunomodulatory action of milk, although the impact of breast-feeding on the gut microflora is probably less than has been widely surmised. Mastitis exerts obvious effects on the composition of milk, but the influence of this condition on the anti-inflammatory and immunomodulatory capacity of milk is unknown. More broadly, there is a need to conduct studies that go beyond the investigation of putative immunomodulators in isolation from one another and from possible gastrointestinal inhibitors. Although long-term influences on the anti-infectious immunocompetence of the neonate are likely, evidence from studies of breast-feeding is equivocal regarding an impact on the risk of developing atopic and autoimmune diseases. In a different vein, Chapter 17 outlines evidence pointing to bovine milk whey as a functional food that promotes development of adaptive immune competence in the early post-weaning stage of life. Evidence is limited to rodents, and studies with resistance to infectious disease as an outcome measure are almost completely lacking. Recent mechanistic speculation centers on the absorption of digestion-resistant whey components such as lactoferrin. However, older literature demonstrating the importance of the amino acid profile of active whey protein concentrates is clearly relevant. Part V centers on factors that influence the immunological properties of colostrum and mature milk. Chapter 18 addresses the influence of maternal dietary and physiological factors on the quantity of milk produced and on the concentrations of milk components considered likely to affect the immunological development of the offspring. In effect, this extends the theme of the preceding chapter, viz. the concept of milk as a functional food. Information is disperse and incomplete. For example, the chapter points out that the composition of human milk beyond six months oflactation is largely undocumented. The importance of early postnatal ontogeny in determining the risk of developing chronic diseases of adulthood places this subject in poignant perspective. Chapter 19 rounds out the volume with a discussion of the influence of storage conditions,

15 Preface xvii processing procedures and feeding methods on the immunologic components of banked human milk. Information on this subject is based on compositional analyses pertaining to biochemical and cellular constituents considered important to the immunological properties of milk. Ultimately, however, banking procedures must be judged on the basis of their impact on the capacity of colostrum and milk to provide passive protection against infection and to promote the development of immune competence in the infant. This remains a matter for future investigation. Bill Woodward

16 Acknowledgment This volume was produced using funds provided by the Dairy Farmers of Canada. xix

17 Contents Part I: Introduction Chapter 1. Overview of the Mammalian Immune System 3 A. J. Husband 1. Introduction Innate Immunity Specific, Adaptive or Acquired Immunity Anatomical Compartmentalization in the Immune System Regulation of Immunity: T Cells and Cytokines Regional Adaptations within the Immune System Ontogeny and Perinatal Immunity Conclusions References Chapter 2. The Immunological System in Human Milk: The Past-A Pathway to the Future Armond S. Goldman 1. Introduction Van Leeuwenhoek, Donne and Leukocytes in Human Milk Antitoxic Effects of Milk Protective Enteric Bacteria in Breast-Fed Infants Antibodies in Human Milk Non-Antibody Protein Defense Agents in Human Milk Non-Protein Defense Agents in Human Milk Concept of a Host Defense System in Human Milk Anti-Inflammatory Agents in Human Milk Immunomodulating Agents in Human Milk Protection of the Immunological System in Human Milk Evolutionary Relationships Between Developmental Delays in the Immune System and the Production of Immune Factors by the Mammary Gland xxi

18 xxii Contents 13. Future Research Immunological Components Formation and Physical State ofimmune Components in Human Milk Fate and Function of Human Milk Immune Factors in the Recipient Immunological TolerancelReduced Immunological Responses Coda Acknowledgments References Chapter 3. Immunological Activities Associated with Milk Shannon L. Kelleher and Eo Lonnerdal Introduction Immunobiological Defense of the Mammary Gland Anatomical Defenses Cellular Defenses Gastrointestinal Microflora Antimicrobial Proteins and Peptides Oligosaccharides Nucleotides Cellular Defenses of Maternal Origin Immunoglobulins, Anti-Idiotypic Antibodies and Hyperimmunization Immunomodulating Agents Including Anti-Inflammatory Components: Cytokines and Non-Cytokine Factors Allergy Considerations Summary References Part II: Milk and Risk of Infection During the Suckling Period Chapter 4. Breast Milk and the Risk of Opportunistic Infection in Infancy in Industrialized and Non-Industrialized Settings Patrick F. W. Chien and Peter W. Howie 1. Introduction Methodological Issues Randomized Trials Time Frame of Evaluated Studies

19 Contents xxiii 2.3. Infective Morbidity as an Outcome Measure Types of Infection Industrialized and N on-industrialized Settings Study Selection and Method of Review Infant Feeding Classification Statistical Methods Industrialized Countries Breast-Feeding and Gastrointestinal Infection Cohort Studies Case-Control Studies Breast-Feeding and Respiratory Tract Infection Cohort Studies Case-Control Studies Breast-Feeding and Primary Invasive Haemophilus injluenzae Infection Case-Control Studies Breast-Feeding and Urinary Tract Infection Case-Control Study Summary of Studies in Industrialized Countries Non-Industrialized Countries Breast-Feeding and Gastrointestinal Infections Cohort Studies Case-Control Studies Breast-Feeding and Respiratory Infections Summary of Studies in Non-Industrialized Countries Overall Perspectives References Chapter 5. Breast Milk Transmission of Viral Disease E. Richard Stiehm and Margaret A. Keller 1. Introduction Herpes Viruses Cytomegalovirus (CMV) Detection in Human Milk Maternal-Infant Transmission Herpes Simplex Virus (HSV) Epstein-Barr Virus (EBV) and Other Human Herpes Viruses (HHV-6, HHV-7, HHV-8) Varicella-Zoster Virus (VSV) Rubella Parvovirus B III HIV

20 xxiv Contents 6. HIV HTLV HTLV Hepatitis A HepatitisB Hepatitis C Summary References , Chapter 6. Breast Milk Decreases the Risk of Neonatal Necrotizing Enterocolitis Ann M. Kosloske 1. Introduction History ofnec Clinical NEC Pathogenesis Ischemia Bacteria Feedings: Formula Feedings: Breast Milk Gut Colonization The Immature Gut Epidemiology Prevention References Chapter 7. The Protective Properties of Milk and Colostrum in Non-Human Species Ian Tizard 1. Introduction Placentation and Passive Immunity Immunoglobulins and Cells in Colostrum and Milk Immunoglobulins Cells Absorption of Colostral Immunoglobulins Fc Receptors Interference with Active Immunity Specific Mammalian Species Marsupials Eutherian Mammals Primates

21 Contents xxv Hystricomorphs Lagomorphs Rodents Carnivores Ungulata Ruminantia Conclusions References Chapter 8. Mammary Gland Defense: The Role of Colostrum, Milk and Involution Secretion Catherine M Fetherston, Chee Seong Lee, and Peter E. Hartmann 1. Introduction Factors Affecting Microbial Invasion of the Mammary Gland Inflammatory Responses to Microbial Invasion of the Mammary Gland Cellular Defense Mechanisms Present in Milk Somatic Cells Factors Affecting Neutrophil Function in Milk Effects of Neutrophil Action on the Mammary Gland Cell Counts as a Diagnostic Measure for Mastitis Non-Cellular Defense Mechanisms in Milk Non-Specific Defense Specific Defense Nutritional Influences on Mastitis and Immunological Defenses in Milk Mastitis: Physiology or Pathology? References Part III: Passively Transferred Anti-Infectious Agents of Milk Chapter 9. Colostrum and Milk in the Treatment of Disease Saeed Hosseini, Paula Inserra, Mohsen Araghi-Niknam, and Ronald R. Watson 1. Introduction Protective Factors in Milk Anti-Bacterial, Anti-Parasitic, and Anti-Viral Effects of Milk Milk Produced by Hyper-Immunized Dairy Cows Conclusion References

22 xxvi Contents Chapter 10. The Role of Human Milk Secretory IgA in Protecting Infants from Bacterial Enteritis Marita Noguera-Obenza and Thomas G. Cleary 1. Introduction Vibrio cholerae Shigella Spp Escherichia coli Salmonella and Non-Typhoidal Salmonella Campylobacter jejuni and C. coli Conclusions References Chapter 11. Chemistry of Milk Mucins and their Anti- Microbial Action H. Schroten 1. Introduction Human MUC Biochemical, Structural and Genetic Characteristics Biosynthesis and Cellular Origin Secreted Milk Mucins Quantitation During Lactation Component A, Alias MUC X Specific Differences Among Milk Mucins Protective Functions of Milk Mucins Acknowledgment References Chapter 12. Antimicrobial Actions of Lactoferrin Roberta Chierici 1. Introduction Biological Activities of Lactoferrin Lactoferrin in Milk Antibacterial Effect of Lactoferrin Antimicrobial Peptides of Lactoferrin Antimicrobial Activity of Lactoferrin in the Gut Other Antibacterial Effects of Lactoferrin Lactoferrin and Helicobacter Pylori Antimicrobial Activity Against Fungi Antiviral Effects of Lactoferrin Conclusions References

23 Contents xxvii Chapter 13. The Antimicrobial Function of Milk Lipids Charles E. Isaacs Introduction Source of Lipid-Dependent Antimicrobial Activity " Lipid-Dependent Antimicrobial Activity in Human Milk Antimicrobial Fatty Acids and Monoglycerides Derived from Human Milk Potential Therapeutic Role of Milk Lipids Summary Acknowledgments References " 281 Chapter 14. The Antimicrobial and Immunomodulating Actions of Milk Leukocytes Gerd Riedel-Caspari 1. Introduction Cytology Macrophages Neutrophils Lymphocytes Adoptive Transfer of Cellular Immunity Through the Colostrum Materno-Fetal Transfer of Systemic Immune Functions Passage of Milk Cells Across the Intestinal Wall Transfer of Pathogenic Microorganisms Via Milk Leukocytes... " Colostral Leukocytes and the Neonate--Friends or Foes? References Part IV: Activity of Milk in Promoting Development of Immunocompetence in the Suckling Neonate Chapter 15. Maturation ofimmunocompetence in Breast-Fed vs. Formula-Fed Infants U 1. Dahlgren, L. A. Hanson, and E. Telemo 1. Introduction Indirect Effects of Breast-Feeding on the Development of the Intestinal Microflora and the Immune System of the Offspring Direct Effects of Breast-Feeding on the Development of the Immune System Breast-Feeding and Allergic Disease Breast-Feeding and Autoimmune Diseases

24 xxviii Contents 6. Conclusions References Chapter 16. Milk Components with Immunomodulatory Potential 327 Suzanne M Filteau 1. Introduction Colostral and Milk Leukocytes Immunomodulatory Activities of the Aqueous Fraction of Milk or Colostrum Cytokines I n t e r l e u k i. n ~ Interleukin-l Receptor Antagonist Interleukin Interleukin Interleukin ; Tumour Necrosis Factor-a Transforming Growth F a c t o... r -. ~ Other Cytokines Other Soluble Aqueous Factors Lactoferrin Prolactin Nucleotides Anti-Idiotypic Antibodies What Conditions Influence the Concentrations of Immune Factors in Milk and Do They Relate to Infant Health? Conclusions Acknowledgments References Chapter 17. Dietary Whey Proteins and Immunocompetence in the Post-Weaning Stages of Life C. W Wong 1. Introduction Dietary Whey Protein Concentrates and Immune Responses Humoral Immune Responses Cell-Mediated Immune Responses Mechanisms and Other Considerations Possible Immunomodulatory Activities of Individual Whey Proteins Lactoferrin Proteins Other Than Lactoferrin

25 Contents xxix 4. Conclusions and Outlook References Part V: External Influences on Defense Components of Milk Chapter 18. Maternal Modulation of Specific and Non-Specific Immune Components of Colostrum and Mature Milk 365 Peter E. Hartmann, Mark D. Cregan, and Leon R. Mitoulas 1. Introduction Milk Production Initiation of Lactation Established Lactation Milk Composition Initiation of Lactation Established Lactation Considerations for the Future Acknowledgments References Chapter 19. Milk Banking: The Influence of Storage Procedures and Subsequent Processing on Immunologic Components of Human Milk Ruth A. Lawrence 1. Introduction Scope Procedures and Containers for Collection and Storage Cooling Effects Freezing Heat Treatment Other Stresses Upon Milk Summary References Index

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