The EFSA Journal (2006) 391a,b,c,d, 1-6
|
|
- Daniel Joseph
- 5 years ago
- Views:
Transcription
1 The EFSA Journal (2006) 391a,b,c,d, 1-6 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Calcium, Magnesium and Zinc Malate added for nutritional purposes to food supplements as sources for Calcium, Magnesium and Zinc and to Calcium Malate added for nutritional purposes to foods for particular nutritional uses and foods intended for the general population as source for Calcium Question n EFSA-Q , 145, 159 and Q Adopted on 27 September 2006 SUMMARY The present opinion only deals with the safety and bioavailability of particular sources of calcium, magnesium and zinc, calcium, magnesium and zinc malates to be used in food supplements and in foods for particular nutritional uses and in foods intended for the general population. The safety of calcium, magnesium and zinc, in terms of the amounts that may be consumed, is outside the remit of this Panel. The Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) has been asked to advice on the safety and bioavailability of magnesium and zinc malate for use in food supplements and calcium malate for use in food supplements, foods for particular nutritional uses and foods intended for the general population. As malates of calcium, magnesium and zinc dissociate in the gastrointestinal tract, the Panel concluded that the bioavailability of calcium, magnesium and zinc from malates is expected to be similar to the bioavailability from other dissociable calcium, magnesium and zinc salts permitted to be used in food and food supplements. On the basis of the data used to establish the existing ADI of DL-malic acid (JECFA, 1986), the Panel also concluded that the use of malates as sources for calcium, magnesium and zinc in food supplements and as source of calcium in foods for particular nutritional uses and foods intended for the general population is of no safety concern. In foods prepared for infants and young children, however, only L-malates should be used according to the previous opinion of the SCF (1992).
2 Malates in food supplements The EFSA Journal (2006) 391 a,b,c,d, p. 2 of 6 KEY WORDS Calcium malate, magnesium malate, zinc malate, malic acid, food supplements, foods for particular nutritional uses, foods intended for the general population. BACKGROUND The European Community legislation lists nutritional substances that may be used for nutritional purposes in certain categories of foods as sources of certain nutrients. The Commission has received requests for the evaluation of calcium, magnesium and zinc malate added for nutritional purposes to food supplements and of calcium malate added for nutritional purposes in foods for particular nutritional uses and foods intended for the general population. The relevant Community legislative measures are: Directive 2002/46/EC of the European Parliament and of the Council on the approximation of the laws of the Member States relating to food supplements (EC, 2002). Commission Directive 2001/15/EC on substances that may be added for specific nutritional purposes in foods for particular nutrition (EC, 2001). In addition, there is a Commission proposal for a regulation on the addition of vitamins and minerals and certain other substances to foods (EC, 2003). TERMS OF REFERENCE In accordance with Article 29 (1) (a) of Regulation (EC) No 178/2002, the European Commission asks the European Food Safety Authority to provide scientific opinions, based on its consideration of the safety and bioavailability of calcium, magnesium and zinc malate added for nutritional purposes to food supplements and of calcium malate added for nutritional purposes in foods for particular nutritional uses and foods intended for the general population. ASSESSMENT Chemistry Calcium, magnesium and zinc malate are salts of malic acid with the chemical formula CaC 4 H 4 O 5, MgC 4 H 4 O 5 and ZnC 4 H 4 O 5 and the CAS Registration Numbers , and , respectively. Information on the chirality of calcium and zinc malate has not been provided. Only the magnesium salt was specified as magnesium DL-malate trihydrate.
3 Malates in food supplements The EFSA Journal (2006) 391 a,b,c,d, p. 3 of 6 Specifications According to the petitioners, calcium and magnesium malate are not less than 97.5% pure and zinc malate not less than 97% pure on anhydrous basis. The proposed specifications of calcium and magnesium malate comply with the specifications of calcium malate and malic acid for use as food additives in Directive 96/77/EC. In the case of zinc malate, maximum levels for malic acid, fumaric acid and cadmium are not given. Exposure According to the petitioners, the quantity of calcium, magnesium and zinc malate to be added to food supplements will be determined by individual formulators, but is normally the quantity necessary to supply adults with up to 2400 mg calcium/day, 250 mg magnesium/day and 15 mg zinc/day, respectively. The maximum total intakes of calcium and zinc from supplements, food, and water were estimated by the petitioner to be 4500 and 77 mg/day, respectively. Based on a potential intake of 2400 mg calcium/day from calcium malate in food supplements as indicated by the petitioners, the equivalent intake of malic acid would be around 8000 mg/day. The intake of malic acid equivalent to 250 mg magnesium/day and 15 mg zinc/day from supplements would be around1400 and 30 mg/day, respectively. In comparison, the daily human consumption of malic acid from its natural occurence in vegetables, fruits and their juices was estimated to be in the order of 1500 to 3000 mg/day (Hartmann and Hillig, 1934). Although this reference is old it is in accordance with data on malic acid in fruits in the range up to 1990 mg/100 g (Souci et al., 2000). Taking into account the maximum levels of malic acid resulting from current good manufacturing practice of e.g. 3.4% for non-alcoholic beverages and 3.5% for processed fruits and fruit juices (FDA, 2003), the intake of malic acid from its use as food additive is likely to be higher than from processed fruits and fruit juices. The Panel notes that malic acid is authorised as a food additive in all foods to quantum satis. Existing authorisations and evaluations DL-malic acid as well as sodium, potassium and calcium malate are permitted food additives with the numbers E296, E350, E351 and E352i, respectively. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) evaluated malic acid and derived on the basis of its well-established metabolic pathway and the daily consumption of malic acid-containing food a group ADI not specified for DL-malic acid and sodium, potassium and calcium DL-malate (JECFA, 1980; JECFA, 1986). The EC Scientific Committee on Food (SCF) agreed with this group ADI (SCF, 1990), but considered only the L-isomer acceptable for use in foods prepared for infants and young children (SCF, 1992). For calcium, magnesium and zinc, the following Tolerable Upper Intake Levels have been established by the SCF: 2500 mg calcium/day for adults from all sources (SCF,
4 Malates in food supplements The EFSA Journal (2006) 391 a,b,c,d, p. 4 of a), 250 mg magnesium/day for readily dissociable magnesium salts and compounds like magnesium oxide not including magnesium normally present in foods and beverages for adults and children from 4 years on (SCF, 2001), and 25 mg zinc/day for adults from all sources (SCF, 2003b). Biological and toxicological data Bioavailability of calcium, magnesium and zinc from their malates Studies on the bioavailability of calcium, magnesium and zinc from their malates in comparison to the commonly used sources for these minerals have not been submitted. Toxicological data The toxicological evaluation is based on the toxicological data on malic acid reviewed by JECFA (1966) and the Cosmetic Ingredient Review Expert Panel (2001) and the data on calcium, magnesium and zinc reviewed by the SCF (2001, 2003a, 2003b). DISCUSSION It can be expected that calcium, magnesium and zinc malate will easily dissolve and dissociate in the gastrointestinal tract and that their cations will be absorbed separately from the malate anion. Therefore, the bioavailability from calcium, magnesium and zinc from malates will likely be in the same range as the bioavailability from other dissociable salts of these minerals. The intake of calcium, magnesium and zinc from malates used in food supplements was estimated by the petitioners to be slightly below or equal to the Tolerable Upper Intake Levels of these cations established by the SCF (2001, 2003a, 2003b). The Panel notes that there are also other sources of calcium, magnesium and zinc that contribute to the total intakes. The intake of malic acid from the use of calcium malate in supplements is relatively high but the well understood metabolism of malic acid and its role in the citric acid cycle does not give rise to any concern. CONCLUSION The present opinion only deals with the safety and bioavailability of particular sources of calcium, magnesium and zinc, calcium, magnesium and zinc malates, to be used in food supplements and in foods for particular nutritional uses and in foods intended for the general population. The safety of calcium, magnesium and zinc, in terms of the amounts that may be consumed, is outside the remit of this Panel.
5 Malates in food supplements The EFSA Journal (2006) 391 a,b,c,d, p. 5 of 6 The Panel concludes that the bioavailability of calcium, magnesium and zinc from malates is expected to be similar to the bioavailability from other dissociable calcium, magnesium and zinc salts permitted to be used for food supplements. The safety evaluation of the malates was based on the data used to establish the existing ADI of DL-malic acid (JECFA, 1986). On this basis, the Panel concluded that the use of calcium, magnesium and zinc malate as sources for calcium, magnesium and zinc in food supplements and of calcium malate in foods for particular nutritional uses and foods intended for the general population as source for calcium is of no safety concern. In foods prepared for infants and young children, however, only L-malates should be used according to the previous opinion of the SCF (1992). DOCUMENTATION PROVIDED TO EFSA Dossier on Calcium Malate. Submitted by Health Food Manufacturers Association, UK (June, 2005). Dossier on Calcium Malate. Application for derogation submitted by Sami Labs Limited, Bangalore, India (July, 2005). Dossier on Magnesium Malate submitted by Health Food Manufacturers Association, UK (May, 2005). Dossier on Zinc Malate. Submitted by Health Food Manufacturers Association, UK (May, 2005). REFERENCES Cosmetic Ingredient Review Expert Panel (2001). Final report on the safety assessment of malic acid and sodium malate. Internat. J. Toxicol. 2O (Suppl.1), EC (2001). Commission Directive 2001/15/EC of 15 February 2001 on substances that may be added for specific nutritional purposes in foods for particular nutritional uses. Official Journal of the European Communities, L52, , pg EC (2002) Directive 2002/46/EC of the European Parliament and of the Council on the approximation of the laws of the Member States relating to food supplements. Official Journal of the European Communities, L183, , pg EC (2003) Commission proposal for a regulation on the addition of vitamin and minerals and certain other substances to foods - COM (2003) 671 final
6 Malates in food supplements The EFSA Journal (2006) 391 a,b,c,d, p. 6 of 6 European Pharmacopoeia (2005). FDA (2003). Fed. Reg CFR Ch. I (4-1-03). Hartmann B.G. and Hillig F. (1934). J. Ass. Off. Agric. Chem. 17(3), 522, quoted by JECFA (1966). JECFA (1966). Toxicological evaluation of some antimicrobials, antioxidants, emulsifiers, stabilizers, flour-treatment agents, acids and bases. FAO Nutrition Meetings Report Series No. 40A,B,C. WHO/Food Add./ JECFA (1980). Evaluation of certain food additives. WHO Technical Report Series JECFA (1986). Evaluation of certain food additives and contaminants. WHO Technical Report Series SCF (1990). First series of food additives of various technological functions (Opinion expressed on 18 May 1990). Reports of the Scientific Committee for Food (Twentyfifth series). SCF (1992). Minutes of the 86th meeting of the Scientific Committee for Food held on 8-9 October SCF (2001). Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Magnesium (expressed on 26 September 2001). SCF (2003a). Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Zinc (expressed on 5 March 2003). SCF (2003b). Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Calcium (expressed on 4 April 2003). Souci S. W., Fachmann W. and Kraut H. (2000). Food Composition and Nutrition Tables. Wiss. Verlagsgesellsch. Stuttgart. SCIENTIFIC PANEL MEMBERS F. Aguilar, H. Autrup, S. Barlow, L. Castle, R. Crebelli, W. Dekant, K.-H. Engel, N. Gontard, D. Gott, S. Grilli, R. Gürtler, J.-C. Larsen, C. Leclercq, J.-C. Leblanc, F. X. Malcata, W. Mennes, M.-R. Milana, I. Pratt, I. Rietjens, P. Tobback, F. Toldrá.
SCIENTIFIC OPINION. Calcium sulphate for use as a source of calcium in food supplements 1
The EFSA Journal (2008) 814, 1-9 SCIENTIFIC OPINION Calcium sulphate for use as a source of calcium in food supplements 1 Scientific Panel on Food Additives and Nutrient Sources added to food (Question
More informationThe EFSA Journal (2006) 390, 1-7
The EFSA Journal (2006) 390, 1-7 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to the use of
More informationThe EFSA Journal (2004) 112, 1-10
The EFSA Journal (2004) 112, 1-10 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and materials in Contact with Food on a request from the Commission related to Calcium
More informationSCIENTIFIC OPINION. Statement of the Panel on Food Additives and Nutrient Sources added to Food
The EFSA Journal (2009) 1077, 1-5 SCIENTIFIC OPINION Inability to assess the safety of calcium amino acid chelate, copper amino acid chelate, magnesium amino acid chelate, manganese amino acid chelate
More informationSCIENTIFIC OPINION. Statement of the Panel on Food Additives and Nutrient Sources added to Food. (Question No EFSA-Q , EFSA-Q )
The EFSA Journal (2009) 953, 1-6 SCIENTIFIC OPINION Inability to assess the safety of chromium (III) and copper (II) ethanolamine phosphate added for nutritional purposes to food supplements based on the
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food
The EFSA Journal (2009) 1103, 1-5 SCIENTIFIC OPINION Inability to assess the safety of potassium amino acid chelate and iron amino acid chelate as sources of potassium and iron added for nutritional purposes
More informationCalcium ascorbate with a content of threonate for use as a source of vitamin C in food supplements. Question number EFSA-Q
The EFSA Journal (2007) 491, 1-10 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food On a request from the Commission related to Calcium
More informationSCIENTIFIC OPINION. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) 2,3
EFSA Journal 2013;11(10):3387 SCIENTIFIC OPINION Scientific Opinion on the safety assessment of the active substances iron, iron oxides, sodium chloride and calcium hydroxide for use in food contact materials
More informationSCIENTIFIC OPINION. Calcium ascorbate, magnesium ascorbate and zinc ascorbate added for nutritional purposes in food supplements 1
The EFSA Journal (2009) 994, 1-22 SCIENTIFIC OPINION Calcium ascorbate, magnesium ascorbate and zinc ascorbate added for nutritional purposes in food supplements 1 Scientific Opinion of the on Food Additives
More informationThe EFSA Journal (2006) 354, 1-7
The EFSA Journal (2006) 354, 1-7 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Maltitol
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food (ANS) Adopted on 4 June 2009
The EFSA Journal (2009) 1119, 1-7 SCIENTIFIC OPINION Inability to assess the safety of calcium-enriched yeast added for nutritional purposes as a source of calcium in food supplements, based on the supporting
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food. (Question No EFSA-Q )
The EFSA Journal (2009) 1117, 1-6 SCIENTIFIC OPINION Inability to assess the safety of sodium hyaluronate added 1 Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food
More informationOpinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
The EFSA Journal (2006) 416 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on the presence of 1,2-Benzisothiazolin-3-one as an impurity
More informationFood additives and nutrient sources added to food: developments since the creation of EFSA
EFSA Journal 2012;10(10):s1006 SPECIAL ISSUE Food additives and nutrient sources added to food: developments since the creation of EFSA Birgit Dusemund, John Gilbert, David Gott, Hugues Kenigswald, Jürgen
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food. (Question No EFSA-Q )
The EFSA Journal (2009) 1148, 1-6 SCIENTIFIC OPINION Inability to assess the safety of vitamin D-enriched yeast added for nutritional purposes as a source of vitamin D in food supplements and the bioavailability
More informationStatement on the Safety Evaluation of Smoke Flavourings Primary Products: Interpretation of the Margin of Safety 1
SCIENTIFIC OPINION Statement on the Safety Evaluation of Smoke Flavourings Primary Products: Interpretation of the Margin of Safety 1 EFSA Panel on Food Contact Material, Enzymes, Flavourings and Processing
More informationMINUTES OF THE 15 TH PLENARY MEETING OF THE SCIENTIFIC PANEL ON FOOD ADDITIVES, FLAVOURINGS, PROCESSING AIDS AND MATERIALS IN CONTACT WITH FOOD
EFSA European Food Safety Authority Parma, 15 February 2006 EFSA/THM/ DS EFSA/AFC/P_M15/MIN-final MINUTES OF THE 15 TH PLENARY MEETING OF THE SCIENTIFIC PANEL ON FOOD ADDITIVES, FLAVOURINGS, PROCESSING
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food. (Question No EFSA-Q )
The EFSA Journal (2009) 1126, 1-6 SCIENTIFIC OPINION Inability to assess the safety of vitamin B 12 -enriched yeast added for nutritional purposes and the bioavailability of vitamin B 12 from this source,
More informationSCIENTIFIC OPINION. Ferrous phosphate added for nutritional purposes to food supplements 1
The EFSA Journal (2009) 951, 1-13 SCIENTIFIC OPINION Ferrous phosphate added for nutritional purposes to food supplements 1 Scientific Opinion of the Panel on Food Additives and Nutrient Sources added
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food (ANS) (Question No EFSA-Q )
The EFSA Journal (2009) 1071, 1-6 SCIENTIFIC OPINION nutritional purposes as a source of boron in food supplements and the bioavailability of boron from this source, based on the supporting dossier 1 Scientific
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food. (Question No EFSA-Q )
The EFSA Journal (2009) 1135, 1-6 SCIENTIFIC OPINION riboflavin-enriched yeast added for nutritional purposes as a source of riboflavin in food supplements and the bioavailability of riboflavin from this
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food (ANS) (Question No EFSA-Q )
The EFSA Journal (2009) 1133, 1-6 SCIENTIFIC OPINION Inability to assess the safety of vitamin C-enriched yeast added for nutritional purposes as a source of vitamin C in food supplements and the bioavailability
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food (ANS) Adopted on 14 May 2009
The EFSA Journal (2009) 1087, 1-6 SCIENTIFIC OPINION Inability to assess the safety of molybdenum-enriched yeast added for nutritional purposes as a source of and the bioavailability of molybdenum from
More informationOpinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request related to
The EFSA Journal (2006) 316 to 318, 1-10 Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request related to an 11 th list of
More informationScientific Opinion on the safety evaluation of the substance, copper hydroxide phosphate, CAS No , for use in food contact materials 1
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, copper hydroxide phosphate, CAS No. 12158-74-6, for use in food contact materials 1 EFSA Panel on food contact materials,
More informationa 1 st list of substances for food contact materials
, 1-9 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to a 1 st list of substances for
More informationSCIENTIFIC OPINION. Scientific Panel on Food Additives and Nutrient Sources added to food (ANS)
The EFSA Journal (2008) 883, 1-23 SCIENTIFIC OPINION Magnesium aspartate, potassium aspartate, magnesium potassium aspartate, calcium aspartate, zinc aspartate, and copper aspartate as sources for magnesium,
More informationSCIENTIFIC OPINION. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF) 2, 3
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, 2,4-bis(2,4-dimethylphenyl)-6-(2-hydroxy-4-n-octyloxyphenyl)-1,3,5- triazine, CAS No. 2725-22-6, for use in food contact
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food. (Question No EFSA-Q )
The EFSA Journal (2009) 1134, 1-6 SCIENTIFIC OPINION Inability to assess the safety of biotin-enriched yeast added for nutritional purposes as a source of biotin in food supplements and the bioavailability
More informationStatement on nitrites in meat products 1
SCIENTIFIC OPINION Statement on nitrites in meat products 1 EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) 2 European Food Safety Authority (EFSA), Parma, Italy ABSTRACT The Panel
More informationSCIENTIFIC OPINION. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) 2, 3
EFSA Journal 2013;11(6):3245 SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the active substances, iron, polyethyleneglycol, disodium pyrophosphate, monosodium phosphate and sodium chloride
More informationSCIENTIFIC OPINION. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) 2, 3
EFSA Journal 2013;11(4):3153 SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the active substances, sodium carbonate peroxyhydrate coated with sodium carbonate and sodium silicate, bentonite,
More informationSCIENTIFIC OPINION. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) 2, 3
EFSA Journal 2012;10(10):2906 SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the active substance iron (II) modified bentonite as oxygen absorber for use in active food contact materials
More informationSCIENTIFIC OPINION. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF) 2, 3
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, (butadiene, styrene, methyl methacrylate) copolymer cross-linked with 1,3- butanediol dimethacrylate, for use in food contact
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food (ANS) Adopted on 5 June 2009
The EFSA Journal (2009) 1130, 1-8 SCIENTIFIC OPINION Inability to assess the safety of iron-enriched yeast, added for nutritional purposes to foods for particular nutritional uses and foods (including
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food (ANS) (Question No EFSA-Q )
The EFSA Journal (2009) 1085, 1-6 SCIENTIFIC OPINION Inability to assess the safety of strontium-enriched yeast added for nutritional purposes as a source of strontium in and the bioavailability of strontium
More informationSCIENTIFIC OPINION. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF) 2, 3
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, poly(12-hydroxystearic acid)-polyethyleneimine copolymer, CAS No. 124578-12-7, for use in food contact materials 1 EFSA
More informationSCIENTIFIC OPINION. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF) 2,3
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, cyclic oligomers of (butylene terephthalate), CAS No. 263244-54-8, for use in food contact materials 1 EFSA Panel on food
More information(Non-legislative acts) REGULATIONS
17.1.2013 Official Journal of the European Union L 13/1 II (Non-legislative acts) REGULATIONS COMMISSION REGULATION (EU) No 25/2013 of 16 January 2013 amending Annexes II and III to Regulation (EC) No
More informationSCIENTIFIC OPINION. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF) 2, 3
EFSA Journal 2011; 9(4):2123 SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, (butadiene, styrene, methyl methacrylate, butyl acrylate) copolymer crosslinked with divinylbenzene
More informationSCIENTIFIC OPINION. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF) 2, 3
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the active substances, activated carbon, water, iron powder, kaolin calcined, sulphur and sodium chloride for use as active component in
More informationFlavouring Group Evaluation 49, (FGE.49) 1 : Xanthin alkaloids from the Priority list from chemical group 30
The EFSA Journal (2008) 741, 1-15 1 : Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA-Q-2003-172D) Adopted on 22 May 2008 SUMMARY
More informationSCIENTIFIC OPINION. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food (ANS) Adopted on 4 June 2009
The EFSA Journal (2009) 1129, 1-10 SCIENTIFIC OPINION Inability to assess the safety of zinc-enriched yeast, added for nutritional purposes to foods for particular nutritional uses and foods (including
More informationScientific Opinion on the safety evaluation of the substance, titanium nitride, nanoparticles, for use in food contact materials 1
EFSA Journal 2012;10(3):2641 ABSTRACT SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, titanium nitride, nanoparticles, for use in food contact materials 1 EFSA Panel on
More informationGUIDANCE ON SUBMISSIONS FOR SAFETY EVALUATION OF SOURCES OF NUTRIENTS OR OF OTHER INGREDIENTS PROPOSED FOR USE IN THE MANUFACTURE OF FOODS
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Scientific Opinions C2 - Management of scientific committee; scientific co-operation and networks Scientific Committee
More informationEuropean Union legislation on Food additives, Food enzymes, Extractions solvents and Food flavourings
European Union legislation on Food additives, Food enzymes, Extractions solvents and Food flavourings European Commission, DG, Unit E3 Chemicals, contaminants and pesticides Serbia-Screening meeting on
More informationThe EFSA Journal (2005) 217, 1-5
The EFSA Journal (2005) 217, 1-5 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission on the application
More informationSafety of the proposed extension of use of sucralose (E 955) in foods for special medical purposes in young children
SCIENTIFIC OPINION ADOPTED: 9 December 2015 PUBLISHED: 19 January 2016 doi:10.2903/j.efsa.2016.4361 Safety of the proposed extension of use of sucralose (E 955) in foods for special medical purposes in
More informationOfficial Journal of the European Union REGULATIONS
L 259/2 REGULATIONS COMMISSION DELEGATED REGULATION (EU) 2017/1798 of 2 June 2017 supplementing Regulation (EU) No 609/2013 of the European Parliament and of the Council as regards the specific compositional
More informationUse of lycopene as a food colour 1. Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
The EFSA Journal (2008) 674, 1-66 Use of lycopene as a food colour 1 Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (Questions No EFSA
More informationTECHNICAL REPORT OF EFSA. List of guidance, guidelines and working documents developed or in use by EFSA 1
EFSA Technical Report (2009) 279, 1-13 TECHNICAL REPORT OF EFSA List of guidance, guidelines and working documents developed or in use by EFSA 1 Prepared by the Secretariat of the Scientific Committee
More informationSCIENTIFIC OPINION. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF) 2, 3
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance,, CAS No. 908020-52-0, for use in food contact materials 1 EFSA Panel on food contact materials, enzymes, flavourings and
More informationSCIENTIFIC OPINION. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) 2, 3. European Food Safety Authority (EFSA), Parma, Italy
SCIENTIFIC OPINION Scientific Opinion on the safety of ferrous ammonium phosphate as a source of iron added for nutritional purposes to foods for the general population (including food supplements) and
More informationScientific opinion on the influence of the composition of drinking water on nutritional profile of infant milk formula
Scientific opinion on the influence of the composition of drinking water on nutritional profile of infant milk formula 59 th meeting of Advisory Forum Parma, 8.-9. March 2016. Andrea Gross-Bošković Background
More informationCOMMISSION DIRECTIVE 96/8/EC of 26 February 1996 on foods intended for use in energy-restricted diets for weight reduction. (OJ L 55, , p.
1996L0008 EN 20.06.2007 001.001 1 This document is meant purely as a documentation tool and the institutions do not assume any liability for its contents B COMMISSION DIRECTIVE 96/8/EC of 26 February 1996
More informationOfficial Journal of the European Union
L 230/8 EN 25.8.2016 COMMISSION REGULATION (EU) 2016/1413 of 24 August 2016 amending Regulation (EU) No 432/2012 establishing a list of permitted health claims made on foods other than those referring
More informationEFSA European Food Safety Authority
EFSA European Food Safety Authority Brussels, 31 January 2004 EFSA/THM EFSA/AFC/P_M04/MIN-final MINUTES OF THE 4 TH PLENARY MEETING OF THE SCIENTIFIC PANEL ON FOOD ADDITIVES, FLAVOURINGS, PROCESSING AIDS
More informationOfficial Journal of the European Communities
L 52/19 COMMISSION DIRECTIVE 2001/15/EC of 15 February 2001 on substances that may be added for specific nutritional purposes in foods for particular nutritional uses (Text with EEA relevance) THE COMMISSION
More informationCOMMISSION REGULATION (EU)
11.3.2011 Official Journal of the European Union L 64/15 COMMISSION REGULATION (EU) No 234/2011 of 10 March 2011 implementing Regulation (EC) No 1331/2008 of the European Parliament and of the Council
More information1. Welcome, apologies for absence Adoption of the agenda Declarations of interest... 3
EFSA European Food Safety Authority Brussels, 7 June 2004 EFSA/THM/DG/DS EFSA/AFC/P_M06/MIN- FINAL MINUTES OF THE 6 TH PLENARY MEETING OF THE SCIENTIFIC PANEL ON FOOD ADDITIVES, FLAVOURINGS, PROCESSING
More informationSCIENTIFIC OPINION. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) 2, 3
EFSA Journal 2013;11(7):3306 SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, 1,3,5-tris(2,2- dimethylpropanamido)benzene, CAS No. 745070-61-5, for use in food contact materials
More informationSCIENTIFIC OPINION. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF) 2, 3
EFSA Journal 2012;10(7):2825 SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, 2-phenyl-3,3-bis(4-hydroxyphenyl)phthalimidine, CAS No. 6607-41-6, for use in food contact
More informationScientific Opinion on the safety evaluation of the substance bis(2,6-diisopropylphenyl)carbodiimide for use in food contact materials 1
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance bis(2,6-diisopropylphenyl)carbodiimide for use in food contact materials 1 EFSA Panel on food contact materials, enzymes,
More informationParma, 21/09/2015 SCIENTIFIC EVALUATION OF REGULATED PRODUCTS DEPARTMENT
SCIENTIFIC EVALUATION OF REGULATED PRODUCTS DEPARTMENT Parma, 21/09/2015 Note on the establishment of a Standing Working Group on Dietary Reference Values for vitamins of the Scientific on Dietetic Products,
More informationScientific Opinion on the safety evaluation of the substance, 3,4-diacetoxy-1-butene, CAS No , for use in food contact materials 1
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, 3,4-diacetoxy-1-butene, CAS No. 18085-02-4, for use in food contact materials 1 EFSA Panel on food contact materials, enzymes,
More informationSCIENTIFIC OPINION. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) 2, 3
EFSA Journal 2013;11(4):3155 SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the active substances iron, sodium chloride, water, silica gel, activated carbon, monosodium glutamate, potassium
More informationCOMMISSION DELEGATED REGULATION (EU).../... of XXX
EUROPEAN COMMISSION Brussels, XXX SANTE/10355/2015 (POOL/E4/2015/10355/10355-EN. doc) [...1(2015) XXX draft COMMISSION DELEGATED REGULATION (EU).../... of XXX supplementmg Regulation (EU) No 609/2013 of
More informationREPORT FROM THE COMMISSION TO THE EUROPEAN PARLIAMENT AND THE COUNCIL
EUROPEAN COMMISSION Brussels, 22.8.2017 COM(2017) 438 final REPORT FROM THE COMMISSION TO THE EUROPEAN PARLIAMENT AND THE COUNCIL on the exercise of the delegation conferred on the Commission pursuant
More informationScientific Opinion on the safety assessment of the active substances, palladium metal and hydrogen gas, for use in active food contact materials 1
EFSA Journal 2014;12(2):3558 SCIENTIFIC OPINION Scientific Opinion on the safety assessment of the active substances, palladium metal and hydrogen gas, for use in active food contact materials 1 EFSA Panel
More informationCOMMISSION DELEGATED REGULATION (EU) /... of XXX
EUROPEAN COMMISSION Brussels, XXX SANTE/11174/2016 (POOL/E1/2016/E1/11174/11174- EN.doc) [ ](2017) XXX draft COMMISSION DELEGATED REGULATION (EU) /... of XXX amending the Annex to Regulation (EU) No 609/2013
More informationSCIENTIFIC OPINION. Copper(II) oxide as a source of copper added for nutritional purposes to food supplements 1
The EFSA Journal (2009) 1089, 1-15 SCIENTIFIC OPINION Copper(II) oxide as a source of copper added for nutritional purposes to food supplements 1 Scientific Opinion of the Panel on Food Additives and Nutrient
More informationScientific Opinion on the safety and efficacy of sodium hydroxide for dogs, cats and ornamental fish 1
EFSA Journal 2012;10(10):2882 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of sodium hydroxide for dogs, cats and ornamental fish 1 EFSA Panel on Additives and Products or Substances
More informationThe EFSA Journal (2004) 162, 1-6
The EFSA Journal (2004) 162, 1-6 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related the use
More informationThis document is meant purely as a documentation tool and the institutions do not assume any liability for its contents
2001L0015 EN 11.04.2006 002.001 1 This document is meant purely as a documentation tool and the institutions do not assume any liability for its contents B COMMISSION DIRECTIVE 2001/15/EC of 15 February
More informationSCIENTIFIC OPINION. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF) 2, 3
SCIENTIFIC PININ Scientific pinion on the safety evaluation of the substance, 3,9-bis[2-(3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionyloxy)-1,1- dimethylethyl]-, CAS No. 90498-90-1, for use in food
More informationExpert Consultation On Nutrient Risk Assessment For Determination Of Safe Upper Levels For Nutrients New Delhi, India, 4 December 2015
Expert Consultation On Nutrient Risk Assessment For Determination Of Safe Upper Levels For Nutrients New Delhi, India, 4 December 2015 Nutrient Risk Assessment & Upper Levels in the EU Basil Mathioudakis
More informationScientific Opinion on the safety evaluation of the substance glycolic acid for use in food contact materials 1
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance glycolic acid for use in food contact materials 1 EFSA Panel on food contact materials, enzymes, flavourings and processing
More informationCOMMISSION REGULATION (EU) / of XXX. authorising certain health claims made on foods and referring to children's development and health
EUROPEAN COMMISSION Brussels, XXX SANTE/10891/2015 [ ](2015) XXX draft COMMISSION REGULATION (EU) / of XXX authorising certain health claims made on foods and referring to children's development and health
More informationFederation of EU Specialty Food Ingredients Industries
Federation of EU Specialty Food Ingredients Industries Additives: - Discovering the new EU positive lists of food additives and preparing for EFSA s re-evaluation system - Getting ready for a changing
More information1 OJ L 354, , p OJ L 80, , p. 19.
Call for scientific and technical data on the permitted food additives sulphur dioxide (E 220), sodium sulphite (E 221), sodium bisulphite (E 222), sodium metabisulphite (E 223), potassium metabisulphite
More informationSCIENTIFIC OPINION. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF) 2, 3
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance perfluoro acetic acid, α-substituted with the copolymer of perfluoro-1,2- propylene glycol and perfluoro-1,1-ethylene glycol,
More informationScientific Opinion on the safety evaluation of the substance, 2,4-diamino-6-hydroxypyrimidine, CAS No , for use in food contact materials 1
SCIENTIFIC OPINION Scientific Opinion on the safety evaluation of the substance, 2,4-diamino-6-hydroxypyrimidine, CAS No. 56-06-4, for 1 EFSA Panel on food contact materials, enzymes, flavourings and processing
More informationCommunity provisions, relevant national rules may apply without prejudice to the provisions of the Treaty.
L 404/26 REGULATION (EC) No 1925/2006 OF THE EUROPEAN PARLIAMT AND OF THE COUNCIL of 20 December 2006 on the addition of vitamins and minerals and of certain other substances to foods THE EUROPEAN PARLIAMT
More information1. Welcome, apologies for absence Adoption of the agenda Declarations of interest... 4
EFSA European Food Safety Authority Brussels, 28 September 2004 EFSA/THM/DG/DS/THM EFSA/AFC/P_M07/MIN-1 MINUTES OF THE 7 TH PLENARY MEETING OF THE SCIENTIFIC PANEL ON FOOD ADDITIVES, FLAVOURINGS, PROCESSING
More informationEUROPEAN FOOD SAFETY AUTHORITY
EUROPEAN FOOD SAFETY AUTHORITY Call for scientific data on food additives permitted in the EU and belonging to the functional classes of emulsifiers, stabilisers and gelling agents Published: 23 November
More information***II POSITION OF THE EUROPEAN PARLIAMENT
EUROPEAN PARLIAMENT 1999 2004 Consolidated legislative document 13 March 2002 2000/0080(COD) PE2 ***II POSITION OF THE EUROPEAN PARLIAMENT adopted at second reading on 13 March 2002 with a view to the
More informationSCIENTIFIC PANEL ON FOOD CONTACT MATERIALS, ENZYMES, FLAVOURINGS AND PROCESSING AIDS (CEF) Parma, 05 December 2011.
CEF UNIT Parma, 05 12 2011 SCIENTIFIC PANEL ON FOOD CONTACT MATERIALS, ENZYMES, FLAVOURINGS AND PROCESSING AIDS (CEF) Minutes of the 4 th meeting of the Working Group (WG) on Processing aids (Teleconference)
More informationCOMMISSION DIRECTIVE 96/8/EC. of 26 February on foods intended for use in energy-restricted diets for weight reduction
No L 55/22 ( ENI Official Journal of the European Communities 6. 3. 96 COMMISSION DIRECTIVE 96/8/EC of 26 February 1996 on foods intended for use in energy-restricted diets for weight reduction (Text with
More informationINTRODUCTION. CODEX STANDARD FOR PROCESSED CEREAL-BASED FOODS FOR INFANTS AND CHILDREN 1 CODEX STAN (amended 1985, 1987, 1989, 1991)
CODEX STAN 74 Page 1 of 7 INTRODUCTION The Codex Standard for Processed Cereal-Based Foods for Infants and Children was adopted by the Codex Alimentarius Commission at its 11th Session in 1976. In 1983,
More informationSafety Assessment of Paprika Extract EXS0570IND. Contact person(s): Céline Burgaud; Pharmanager Ingredients Céline Pozza, Pharmanager development
Safety Assessment of Paprika Extract EXS0570IND Name of Applicant: Pharmanager Ingredients, France Contact person(s): Céline Burgaud; Pharmanager Ingredients Céline Pozza, Pharmanager development Novel
More informationSTANDARD FOR FOLLOW-UP FORMULA CODEX STAN Adopted in Amended in 1989, 2011, 2017.
STANDARD FOR FOLLOW-UP FORMULA CODEX STAN 156-1987 Adopted in 1987. Amended in 1989, 2011, 2017. CODEX STAN 156-1987 2 1. SCOPE This standard applies to the composition and labelling of follow-up formula.
More informationOfficial Journal of the European Union L 51/7
20.2.2007 Official Journal of the European Union L 51/7 COMMISSION REGULATION (EC) No 162/2007 of 1 February 2007 amending Regulation (EC) No 2003/2003 of the European Parliament and of the Council relating
More informationThe Food for Specific Groups (Information and Compositional Requirements) (England) Regulations 2016
INFORMATION NOTE INTENDED FOR KNOWLEDGE HUB The Food for Specific Groups (Information and Compositional Requirements) (England) Regulations 2016 This note is to alert you to the fact that the English Statutory
More informationCIAA Comments to DG SANCO Discussion Paper on the setting of maximum and minimum amounts for vitamins and minerals in foodstuffs
CIAA Comments to DG SANCO Discussion Paper on the setting of maximum and minimum amounts for vitamins and minerals in foodstuffs SETTING OF MAXIMUM AMOUNTS CIAA welcomes the DG SANCO initiative to consult
More informationThe effect of growth regulators on callus colors and production of somatic embryos In Vitro of Rosemary Plant (Rosmarinus officinalis L.
IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS) e-issn: 2319-2380, p-issn: 2319-2372. Volume 8, Issue 9 Ver. I (Sep. 2015), PP 96-100 www.iosrjournals.org The effect of growth regulators
More informationWhich foods may carry nutrition and health claims? Update from EFSA
Which foods may carry nutrition and health claims? Update from EFSA Leng HENG Unit on Dietetic Products, Nutrition and Allergies (NDA) EFET Conference - 22 Oct 2010, Athens 1 2 Outline EFSA Panel on Dietetic
More informationComparison of Regulations in India and EU
Dr. Carel Wreesmann Comparison of Regulations in India and EU A Case Study EDTA - Ferric Sodium EDTA ILSI - India April 30 th, 2011 Lay-out EDTA FeNa-EDTA JECFA 1993 2007 US FDA 2006 WHO 2009 EFSA / EU
More informationStatement on two recent scientific articles on the safety of artificial sweeteners 1
EFSA Journal 2011;9(2):1996 SCIENTIFIC OPINION Statement on two recent scientific articles on the safety of artificial sweeteners 1 EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)
More informationthe use of partially depolymerised guar gum as a food additive Question N EFSA-Q Adopted on 4 July 2007
The EFSA Journal (2007) 514, 1-17 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to an application
More informationEUROPEAN PARLIAMENT C5-0640/2001. Common position. Session document 2000/0080(COD) 10/12/2001
EUROPEAN PARLIAMENT 1999 Session document 2004 C5-0640/2001 2000/0080(COD) EN 10/12/2001 Common position adopted by the Council on 3 December 2001 with a view to the adoption of a Directive of the European
More information