Fall Pediatric Nutritional Products Guide

Transcription

1 Fall 2018 Pediatric Nutritional Products Guide

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3 ABBOTT NUTRITION PEDIATRIC NUTRITIONAL PRODUCTS GUIDE WELCOME TO ABBOTT NUTRITION PEDIATRIC NUTRITIONALS This product guide provides a detailed nutritional overview of our products intended for infants and children. Our goal is to help you provide the best care for your patient by helping you with product selection. An electronic version of this guide is available at abbottnutrition.ca and is updated on a regular basis. Please refer to the product label for the most current information. Although every effort is made to ensure that all information is correct at the time of printing, values and instructions are subject to change. QUESTIONS OR COMMENTS Health care professionals can contact Abbott Nutrition Communications, a team of product specialists and registered dietitians, who can answer your product-related questions. Call: , option 1 canada.nutrition@abbott.com Service 7 days a week ORDERING To order Abbott Nutrition products contact Customer Service. Call: , option 2 salesorder@abbott.com Monday Friday 8:30 a.m. - 5 p.m., ET Thank you for choosing Abbott Nutrition, a world leader in nutritional products for infants, children and adults. Your nutrition partner Like you, we care 3

4 TABLE OF CONTENTS GENERAL INFORMATION Abbott Nutrition Hospital Feeding System (HFS)...6 Indications for Use...7 Allergens...11 Infant Formula Preparation Guidelines and Dilution Charts...12 Storage Guidelines...13 Recommended Hang Times...14 Expiration Dates...14 Warnings...14 Healthy Babies Begin with Healthy Moms...17 Caring for Our Tiniest Patients...23 Breast Milk - Inspiring Our Research and Innovation...47 Learn about scfos...83 Dosage Chart (Pedialyte ) PRODUCTS Pregnant Women and Breastfeeding Moms Similac Mom...18 Preterm Infants Similac Human Milk Fortifier Special Care 30 Omega-3 and Omega Similac Human Milk Fortifier...28 LiquiProtein...32 Similac Special Care 20 Omega-3 and Omega-6 (HFS)...34 Similac Special Care 24 Omega-3 and Omega-6 (HFS)...36 Similac Special Care 24 High Protein Omega-3 and Omega-6 (HFS)...38 Similac Neosure...40 Similac Neosure Omega-3 and Omega-6 (HFS)...42 Term Infants Similac Advance Step 1 Non-GMO...48 Similac Advance Step 1 Non-GMO (HFS)...50 Similac Advance Step 2 Non-GMO...52 Similac Step 2 Non-GMO...54 Similac Step 1 Non-GMO...56 Similac Lower Iron Step 1 Non-GMO Continued on next page

5 TABLE OF CONTENTS Term Infants (continued) Similac Total Comfort Step 1 Non-GMO...60 Similac Sensitive Lactose Sensitivity Step 1 Non-GMO...62 Similac Sensitive for babies sensitive to lactose (HFS)...64 Similac Isomil Step 1 with DHA...66 Similac Isomil Omega-3 and Omega-6 (HFS)...68 Similac Isomil Step 1 Non-GMO...70 Similac 24 Omega-3 and Omega-6 (HFS)...72 Similac Alimentum...74 Similac Alimentum (RTU)...76 Similac Alimentum Omega-3 and Omega-6 (HFS)...78 Toddlers and Children Go & Grow by Similac Step Go & Grow by Similac Step 3 (RTU)...86 PediaSure Complete Grow & Gain...88 PediaSure...90 PediaSure Fibre...92 PediaSure Plus (with fibre)...94 PediaSure Peptide 1 Cal...96 Specialty Products Pedialyte Pedialyte AdvancedCare TM Pedialyte Powder Sachets Pedialyte Freezer Pops Pedialyte (HFS) Similac 5% Glucose Water (HFS) Similac Sterilized Water (HFS) RCF Accessories Component Nipple System Plastic Bottle and Cap CustomFeed Bottle Additional Information Alberta Reimbursement List Ontario Reimbursement List Québec Reimbursement List Saskatchewan Reimbursement List

6 ABBOTT NUTRITION HOSPITAL FEEDING SYSTEM (HFS) Similac has been trusted by health care professionals and parents for close to a century Our hospital portfolio consists of scientifically formulated and researched products to help meet a wide range of infant, parental, and health care professional needs. The most comprehensive line of hospital feeding system products, featuring: Powder and sterile liquid human milk fortifiers (unique to Abbott). An extensively hydrolyzed liquid protein fortifier designed for use in preterm infants (unique to Abbott). A variety of nutrient-enriched preterm formulas, including a post-discharge formula, with different energy and protein densities to meet the nutritional needs of preterm babies. An individually wrapped, sterile breast milk storage bottle (CustomFeed bottle and cap) as well as other useful accessories, such as nipples and a 240-mL plastic bottle. A broad selection of term formulas: From starter formula to formulas designed for infants with allergies and nutritional sensitivities and formulas that address a wide range of parental preferences including non-gmo, vegetarian, kosher, and halal. 2D matrix bar coding technology that allows for multiple track-and-trace capabilities and includes product ID, expiration date and batch/lot number to help prevent misfeeds. Availability See individual product listings. Ingredients not genetically engineered. Universal 2D matrix and linear barcode technologies can be read across various tracking systems. 6

7 INDICATIONS FOR USE Suggested indications do not replace the clinical judgment of the health care professional who is aware of the patient's complete medical history. Please note that this is not a complete listing of all possible products/uses and that the products in each category are not listed in order of preference. Allergy to Cow s Milk Protein Similac Alimentum When tolerance to soy has been established: Similac Isomil Human Milk Fortification Options Similac Human Milk Fortifier Special Care 30 Omega-3 and Omega-6 Similac Human Milk Fortifier LiquiProtein Burns (children 1-13 years of age) PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Peptide 1 Cal Celiac Disease All Abbott Nutrition pediatric products are gluten-free with the exception of PediaSure Plus (with fibre). Colic Symptoms (due to cow s milk protein sensitivity) Similac Alimentum Colitis Similac Alimentum PediaSure Peptide 1 Cal Dehydration/Oral Hydration Pedialyte AdvancedCare Pedialyte Pedialyte Powder Sachets Pedialyte Freezer Pops Continued on next page 7

8 INDICATIONS FOR USE Diarrhea Similac Sensitive Lactose Sensitivity Similac Alimentum PediaSure Peptide 1 Cal Pedialyte AdvancedCare Pedialyte Pedialyte Powder Sachets Pedialyte Freezer Pops Growth Faltering (children 1-13 years of age) PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Complete Grow & Gain Fat Intolerance/Malabsorption Similac Alimentum PediaSure Peptide 1 Cal Fussiness/Gas Similac Total Comfort Similac Sensitive Lactose Sensitivity Similac Isomil Similac Alimentum Galactosemia Similac Isomil Powder is the preferred form for infants with galactosemia. Impaired Gastrointestinal Function Similac Alimentum PediaSure Peptide 1 Cal Inborn Errors of Metabolism Similac Isomil RCF 8 Continued on next page

9 INDICATIONS FOR USE Kosher Abbott Nutrition pediatric products that are certified kosher have one of the following kosher indications, as applicable, on the product label or ingredient list: kosher and dairy by (U-D) and pareve by U Pareve. This information is also available in the TECHNICAL DATA section of each product in this guide. Lactose Intolerance/Sensitivity All Abbott Nutrition products, with the exception of Similac Isomil and our Specialty Products, contain some milk protein. With improvements in testing methodology, low levels of lactose in the products can now be detected. Most people with lactose intolerance can tolerate some amount of lactose in their diet. A review of the medical and scientific literature 1,2 suggests that most lactose intolerant patients could tolerate up to 6 g of lactose per serving. The products listed below contain less than 500 mg of lactose per serving and are therefore suitable for most people with lactose intolerance. Similac Mom Similac Total Comfort Similac Sensitive Lactose Sensitivity Similac Isomil Similac Alimentum PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Peptide 1 Cal PediaSure Complete Grow & Gain REFERENCES: 1. Suarez F. Abbott Nutrition Medical assessment of lactose tolerance in the lactose maldigesters population. April Hertzler SR, Huynh BC, Savaiano DA. How much lactose is low lactose? J Am Diet Assoc 1996;96: Continued on next page 9

10 INDICATIONS FOR USE Pre- and Post-Operative (children 1-13 years of age) PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Peptide 1 Cal PediaSure Complete Grow & Gain Premature/Low-Birth-Weight Infants Similac Human Milk Fortifier Special Care 30 Omega-3 and Omega-6 Similac Human Milk Fortifier LiquiProtein Similac Special Care 20 Omega-3 and Omega-6 Similac Special Care 24 Omega-3 and Omega-6 Similac Special Care 24 High Protein Omega-3 and Omega-6 Similac Neosure Protein Maldigestion Similac Alimentum PediaSure Peptide 1 Cal Toddlers/Children Go & Grow by Similac Step 3 Similac Advance Step 2 Similac Step 2 PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Peptide 1 Cal PediaSure Complete Grow & Gain Pedialyte AdvancedCare Pedialyte Pedialyte Powder Sachets Pedialyte Freezer Pops 10

11 ALLERGENS Abbott Nutrition realizes the importance of product information for you and your patients, especially when managing allergies and intolerances. Priority food allergens and ingredients associated with intolerances and sensitivities are now listed following the ingredients list of each Abbott Nutrition product in this guide. The following foods or protein derived from one of these foods are considered priority food allergens in Canada: Peanuts Eggs Milk Mustard Tree nuts Wheat Soy Sesame seeds Seafood (refers to all edible fish, crustaceans and shellfish) Sulphites The following ingredients may be associated with food intolerances and/or sensitivities: Other soy components (components other than protein including soy oil, soy lecithin and soy fibre) Corn (in the form of maltodextrin, dextrose, corn syrup, corn starch and corn oil) Gluten Colours Flavours (natural and artificial) Citric acid Coconut oil Lactose The information contained in this guide was accurate at the time of publication. The most current information may be obtained by referring to product labels. For additional information on product ingredients related to food allergies and intolerances, please contact our team of product specialists and registered dietitians at , option 1. REFERENCE: Health Canada. Food Allergies ( 11

12 INFANT FORMULA PREPARATION GUIDELINES AND DILUTION CHARTS FOR HEALTH CARE PROFESSIONAL USE ONLY Hypocaloric and hypercaloric formulas should be used under medical supervision. Modifications (decrease/increase) of minerals and vitamins must be taken into consideration. Closer monitoring may be necessary. 27 Cal/30 ml or more calorically dense formula may not supply enough water for some infants. Hydration status should be monitored and water supplied from other sources if necessary. Gastrointestinal tolerance of hypo/hypercaloric formula may differ from standard dilution formula. Closer monitoring may be necessary. For improved tolerance, it is best to increase caloric density slowly, by 2- to 4-Cal/30 ml increments. Ready to use (cans and HFS bottles) Do not dilute. Concentrated Liquid (40 Cal/30 ml) Standard dilution (20 Cal/30 ml) is one part concentrated liquid to one part water. See back of product label for detailed preparation instructions. Caloric Density 1 Concentrated Water Final (Cal/30 ml) Liquid (ml) + (ml) = Volume (ml) 20 (standard) Powder Standard dilution (20 Cal/30 ml) is one level unpacked scoop of powder for each 60 ml of water. See product label for detailed preparation instructions. Caloric Density 1 (Cal/30 ml) Unpacked Level Scoop(s) + Water (ml) = Approximate Yield (ml) 20 (standard) Scoop Measurement and Displacement Volumes for Infant Powders Product Preterm Infants Grams of powder per scoop Displacement volume per scoop (ml) Displacement volume per g of powder (ml) Similac Neosure Similac Human Milk Fortifier 0.69 Term Infants Similac Alimentum Similac Advance Step Similac Advance Step Similac Step Similac Lower Iron Similac Sensitive Lactose Sensitivity Similac Step Similac Isomil Step Similac Isomil with DHA Similac Total Comfort TM Go & Grow by Similac Step Use only scoop provided in the container. Values are approximate. Per 0.9 g packet. REFERENCE: 1. Adapted from Young T, Mangum B. Dilution Tables Neofax 17th ed. Raleigh NC 2004:

13 STORAGE GUIDELINES TO ENSURE THE HIGHEST QUALITY OF UNOPENED PRODUCTS Ready to use or concentrated liquid Store at room temperature. Avoid extreme temperatures. Do not freeze. While the product would remain sterile and the nutritional quality should not be affected, there could be changes to the physical consistency of the product that could affect its appearance, flavour, and other sensory attributes. 45 C 40 C 35 C 30 C 25 C 20 C 15 C 10 C 5 C 0 C -5 C -10 C -15 C Powder Store in dry, cool area. Do not refrigerate. GUIDELINES FOR PREPARING AND STORING FORMULA Human Milk Fortifiers See individual product pages for storage instructions of: Similac Human Milk Fortifier Special Care 30 Omega-3 and Omega-6 Similac Human Milk Fortifier LiquiProtein Ready to use Cans and bottles: after opening, cover, refrigerate, and use within 48 hours. 945-mL reclosable plastic bottles: re-cap, refrigerate, and use within 72 hours. Concentrated Liquid Open can (undiluted): cover, refrigerate, and use within 48 hours. Prepare as per label instructions. Pour into individual feeding bottles or cups, cover, and store in refrigerator. Use prepared formula within 48 hours. Powder Prepare as per label instructions. Pour into individual feeding bottles or cups, cover, and store in refrigerator. Use within 24 hours. Cover opened container after each use. Use product within 1 month of opening container. If ready-to-use, undiluted, or prepared formula is left at room temperature, it should be used within 2 hours. 1 Continued on next page 13

14 STORAGE GUIDELINES GUIDELINES FOR PREPARING AND STORING FORMULA (continued) Once feeding begins (first time the baby s mouth comes into contact with the nipple), use within 1 hour or discard. Do not reuse plastic bottles. For PediaSure products and Similac Mom, if product is consumed directly from the original container (includes use of straw): Use or refrigerate within 1 hour. If refrigerated, use product within 24 hours. RECOMMENDED HANG TIMES Ready to use (commercially sterile) 4-8 hours when carefully poured from bottle/can into an enteral-feeding setup. 2 Reconstituted formulas Includes: Concentrated liquid, powder, any formula to which a modular product has been added, or fortified human milk. Prepare using aseptic technique. Hang for no more than 4 hours. 2 Health care facilities should have guidelines in place for using safe techniques in the preparation and use of tube feedings and in setting quality assurance protocols for monitoring those techniques. EXPIRATION DATES To ensure the highest quality, use the formula by the date indicated. The vitamin content and the physical stability of the product cannot be guaranteed beyond the expiry date because both may degrade with time. WARNINGS Never use a microwave oven to warm formula; serious burns can result. Abbott Nutrition products are not intended for parenteral use. This practice exposes the product to significant amounts of bacteria. REFERENCES: 1. Health Canada Preparing and Handling Powdered Infant Formula. eating-nutrition/safety-salubrite/formula-nourrisson-eng.php. April 12, Accessed on May 29, Robbins ST, Meyers R. Infant feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. 2nd ed. American Dietetic Association. Pediatric Nutrition Practice Group

15 PREGNANT WOMEN AND BREASTFEEDING MOMS Pregnant Women and Breastfeeding Moms IN THIS SECTION Similac Mom

16 Pregnant Women and Breastfeeding Moms PREGNANT WOMEN AND BREASTFEEDING MOMS

17 HEALTHY BABIES BEGIN WITH HEALTHY MOMS PREGNANT WOMEN AND BREASTFEEDING MOMS HAVE UNIQUE NUTRITIONAL NEEDS Healthy eating plays an important role in a healthy pregnancy. A balanced diet helps support both the mom and the baby s health and provides specific nutrients that are particularly important during pregnancy, including protein, iron, calcium, vitamin D, vitamin B12, and folic acid. Breast milk is the ideal food for babies, 1 and breastfeeding moms require optimal nutrition to ensure they have enough energy to give their baby their best. Similac Mom is the first and only nutritional beverage for pregnant women and breastfeeding moms, to help them meet their nutritional needs. For information on the complete Abbott Nutrition adult product line, visit us at abbottnutrition.ca or call , option 1, to speak to our team of product specialist and registered dietitians. REFERENCE: 1. Health Canada, Canadian Paediatric Society, Dietitians of Canada, & Breastfeeding Committee for Canada (2014). Nutrition for healthy term infants: Recommendations from birth to six months. 17

18 SIMILAC MOM Complete, balanced nutrition For pregnant women and breastfeeding moms INDICATIONS FOR USE For pregnant or breastfeeding women: - Who would benefit from a nutritious snack. - With increased caloric needs. - Who require increased protein, vitamins and minerals. To be used as part of an overall healthy diet that includes following doctor s recommendations for using prenatal vitamins. For use with or between meals or, in appropriate amounts, as a meal replacement. Recommended intake: 1 serving per day along with the use of prenatal vitamins. For oral feeding only not for tube feeding. Safety precautions: Not for parenteral use. Not for people with galactosemia. Not intended for use in infants or children. FEATURES AND BENEFITS Complete, balanced nutrition. Provides 26 vitamins and minerals. Convenient source of protein and energy to help meet the increased needs of pregnant women and breastfeeding moms. Convenient, reclosable bottle. 2 delicious flavours: Vanilla and Chocolate. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.96 Protein (% of total energy) 21 Fat (% of total energy) 24 Carbohydrate (% of total energy) 55 Total Cal:g nitrogen ratio 122:1 Non-protein Cal:g nitrogen ratio 96:1 Water (g/l) 837 Osmolality (mosm/kg water) 546 Renal solute load (mosm/l) 417 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Mom, Vanilla 235-mL bottles 4 x 6/case Similac Mom, Chocolate 235-mL bottles 4 x 6/case 18

19 ENERGY Per 235 ml Per 100 ml ENERGY (Cal [kj]) 225 (945) 96 (402) PROTEIN (g) % of total energy 21 Arginine (mg) - - Taurine (mg) - - Carnitine (mg) - - Sodium and calcium caseinates, soy protein isolate FAT (g) % of total energy 24 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) Docosahexaenoic acid (DHA) (g) - - Omega-6:Omega-3 ratio 7.4:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High Oleic safflower oil, canola oil, corn oil, soy lecithin MCT oil (% of total fats) 0 CARBOHYDRATE (g) % of total energy 55 Total dietary fibre (g) - - Short-chain fructooligosaccharides - - (scfos) (g) Galactooligosaccharides (GOS) (g) - - Sucrose, corn maltodextrin Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 350 (1166) 149 (496) Vitamin D3 (mcg [IU]) 1.25 (50) 0.53 (21.3) Vitamin E (IU) Vitamin K1 (mg) - - Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) - - MINERALS Sodium (mg [mmol]) 290 (12.6) 123 (5.3) Potassium (mg [mmol]) 428 (11.0) 182 (4.7) Chloride (mg [mmol]) 251 (7.1) 107 (3.0) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodide (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION Nutritional information for Similac Mom, Vanilla, 235 ml. INGREDIENTS Similac Mom, Vanilla: Water, sugar, sodium and calcium caseinate, corn maltodextrin, high oleic safflower oil, canola oil, soy protein isolate, corn oil, natural and artificial flavours, soy lecithin, carrageenan, MINERALS (potassium citrate, sodium citrate, calcium phosphate, magnesium phosphate, magnesium chloride, salt, potassium phosphate, zinc sulphate, ferrous sulphate, manganese sulphate, cupric sulphate, potassium iodide, sodium molybdate, sodium selenate, chromium chloride), VITAMINS (ascorbic acid, niacinamide, dl-α-tocopheryl acetate, calcium d-pantothenate, vitamin A palmitate, pyridoxine hydrochloride, thiamine chloride hydrochloride, riboflavin, folic acid, biotin, vitamin D3, cyanocobalamin). Contains: milk, soy. Not suitable for individuals with galactosemia. CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, natural and artificial flavour, lactose, other soy components. Additional ingredients for chocolate: Cocoa powder, colour. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC MOM Complete, balanced nutrition For pregnant women and breastfeeding mom

20 NOTES:

21 PRETERM INFANTS Preterm Infants IN THIS SECTION Similac Human Milk Fortifier Special Care 30 Omega-3 and Omega-6 Similac Human Milk Fortifier LiquiProtein Similac Special Care 20 Omega-3 and Omega-6 (HFS) Similac Special Care 24 Omega-3 and Omega-6 (HFS) Similac Special Care 24 High Protein Omega-3 and Omega-6 (HFS) Similac Neosure Similac Neosure Omega-3 and Omega-6 (HFS)

22 Preterm Infants PRETERM INFANTS

23 CARING FOR OUR TINIEST PATIENTS ABBOTT NUTRITION - GIVING HEALTH CARE PROVIDERS THE POWER TO DO MORE Without the chance to develop fully in utero, infants born prematurely are physiologically different from term infants. Early nutrition is a key factor in their survival. Each preterm baby has individual needs, and these needs vary over time after birth. Human milk is the feeding of choice for preterm infants. However, neither human milk nor term infant formulas provide preterm and low-birth-weight babies with the necessary levels of nutrients for catch-up growth and optimal development. Human milk, once supplemented with human milk fortifier, provides adequate amounts of energy and most nutrients, with the exception of protein, which oftentimes requires additional supplementation. 1 To help you meet the unique and varied nutritional needs of preterm infants, Abbott Nutrition has developed a wide range of infant nutritional products, including the most comprehensive line of human milk fortification options: 1) Human milk fortification options Similac Human Milk Fortifier Special Care 30 Omega-3 and Omega-6 Unique to Abbott Nutrition Similac Human Milk Fortifier LiquiProtein Unique to Abbott Nutrition 2) Preterm formulas, available in various caloric and protein densities Similac Special Care 20 Omega-3 and Omega-6 Similac Special Care 24 Omega-3 and Omega-6 Similac Special Care 24 High Protein Omega-3 and Omega-6 3) Preterm, post-discharge formula Similac Neosure Follow hospital guidelines for handling of human milk. REFERENCE: 1. Koletzko B, Poindexter B, Uauy R (eds): Nutritional Care of Preterm Infants: Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2014, vol 110, pp

24 SIMILAC HUMAN MILK FORTIFIER SPECIAL CARE 30 OMEGA-3 AND OMEGA-6 Liquid Human Milk Fortifier For preterm or low-birth-weight infants INDICATIONS FOR USE With human milk: As a human milk fortifier: For preterm or low-birth-weight infants who are nourished with human milk and require fortification to meet their high nutritional needs. To extend the volume of preterm human milk if mother s milk supply is limited. 1 Can be mixed with human milk and fortified human milk to a variety of caloric densities. Using the Similac Liqui-Mix System: Suitable for mixing with any Similac Special Care preterm infant formula using the Similac Liqui-Mix System to a variety of different caloric densities. For oral or tube feeding use. Safety precautions: Use under medical supervision. For hospital use. Follow hospital rules for safe handling of human milk and infant feedings. Once tolerance to enteral feeding with human milk is wellestablished, Similac Human Milk Fortifier Special Care 30 Omega-3 and Omega-6 can be added to human milk. If signs of intolerance develop, slow feeding or discontinue. Not intended for feeding premature infants after they reach a weight of approximately 3600 g (approximately 8 lb) unless otherwise directed by the health care professional. Not for parenteral use. FEATURES AND BENEFITS Sterile liquid formulation. - Easy to mix. - Safer choice for preterm and low-birth-weight infants under 2 months of age or immunocompromised infants. 2 - When available, liquid human milk fortifiers are preferable to powders because they are sterile. 3 When mixed 1:1 with human milk: - Provides 25 Cal/30 ml (84 Cal/100 ml) to meet the energy needs of most preterm infants. 4,5 - Increases the calcium and phosphorus content of human milk to support growing bones. 5,6 - Optimizes the nutrient content of human milk without increasing the osmolality. - Nearly isotonic at 310 mosm/kg water. Contains DHA, an Omega-3 fatty acid, and ARA, an Omega-6 fatty acid to support the normal physical development of the brain and eyes. 7 TECHNICAL DATA Ready to mix Caloric density (Cal/mL) 1.01 Protein (% of total energy) 12.0 Fat (% of total energy) 57.1 Carbohydrate (% of total energy) 30.9 Total Cal:g nitrogen ratio 209:1 Non-protein Cal:g nitrogen ratio 184:1 Water (g/l) 850 Osmolality (mosm/kg water) 325 Renal solute load (mosm/l) 282 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to mix Similac Human Milk Fortifier 59-mL plastic 48/case Special Care 30 Omega-3 bottles and Omega-6 24

25 PREPARATION Proper hygiene, handling and storage are important when preparing infant feedings. 1) Add fortifier to desired quantity of human milk, fortified human milk or to any Similac Special Care preterm infant formula using the Similac Liqui-Mix System as specified by a health care professional. 2) Gently swirl to mix. 3) Warm as per usual nursery practices. 4) Cover and refrigerate unused liquid fortifier after opening; use within 24 hours or discard. 5) If feeding is not used immediately, cover prepared mixture and store in refrigerator. Use within 24 hours 3 or according to hospital procedure. 6) Once feeding begins, use within 1 hour or discard. For tube feedings, hang for no more than 4 hours. 3 ENERGY Ready to mix Per 100 ml Ready to mix Per 59 ml ENERGY (Cal [kj]) 101 (424) 60 (251) PROTEIN (g) % of total energy 12.0 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Threonine (mg) Tryptophan (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry or condensed skim milk, whey protein concentrate FAT (g) % of total energy 57.1 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 6.8:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) (MCT oil) Medium chain triglycerides, soy oil, coconut oil, ARA and DHA MCT oil (% of total fats) 48.9 CARBOHYDRATE (g) % of total energy 30.9 Total dietary fibre (g) - - Short-chain fructooligosaccharides - - (scfos) (g) Galactooligosaccharides (GOS) (g) - - Corn syrup solids, lactose Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 380 (1268) 224 (748) Vitamin D3 (mcg [IU]) 3.80 (152) 2.24 (90) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) 10 6 Inositol (mg) Lutein (mg) - - MINERALS Sodium (mg [mmol]) 44 (1.91) 26 (1.13) Potassium (mg [mmol]) 131 (3.36) 77 (1.98) Chloride (mg [mmol]) 82 (2.31) 48 (1.36) Calcium (mg) Phosphorus (mg) Magnesium (mg) 12 7 Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) - - Molybdenum (mg) - - INGREDIENTS Similac Human Milk Fortifier Special Care 30 Omega-3 and Omega-6, Ready to mix: Water, dry or condensed skim milk, corn syrup solids, medium chain triglycerides (modified coconut and/or palm kernel oils), soy oil, whey protein concentrate, coconut oil, lactose, calcium phosphate, ascorbic acid, calcium carbonate, M. alpina oil *, soy lecithin, monoglycerides, C. cohnii oil **, magnesium chloride, sodium citrate, m-inositol, potassium hydroxide, carrageenan, ferrous sulphate, choline bitartrate, taurine, choline chloride, niacinamide, L-carnitine, zinc sulphate, d-α-tocopheryl acetate, cytidine 5'-monophosphate, calcium d-pantothenate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, vitamin A palmitate, riboflavin, cupric sulphate, thiamine chloride hydrochloride, potassium citrate, pyridoxine hydrochloride, folic acid, manganese sulphate, biotin, phylloquinone, β-carotene, vitamin D3, sodium selenate, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. 25 NUTRITIONAL INFORMATION

26 Nutrient Values of Preterm Human Milk (PTHM) + Similac Human Milk Fortifier Special Care 30 Omega-3 and Omega-6 (SHMF SC30) Per 100 Cal ENERGY PTHM 8 PTHM + SHMF SC30 1:1 RATIO 1:2 2:1 RATIO RATIO Cal/30 ml ENERGY (CAL) Volume (ml) PROTEIN (g) FAT (g) Linoleic acid (g) CARBOHYDRATE (g) VITAMINS Vitamin A (IU) Vitamin D3 (IU) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) Potassium (mg [mmol]) Chloride (mg [mmol]) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) OTHER CHARACTERISTICS PRSL (mosm/l) Water (g) Osmolality (mosm/kg water) PER 100 ml ENERGY PTHM 8 PTHM + SHMF SC30 1:1 RATIO 1:2 2:1 RATIO RATIO Cal/30 ml ENERGY (CAL) Volume (ml) PROTEIN (g) FAT (g) Linoleic acid (g) CARBOHYDRATE (g) VITAMINS Vitamin A (IU) Vitamin D3 (IU) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) Potassium (mg [mmol]) Chloride (mg [mmol]) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) OTHER CHARACTERISTICS PRSL (mosm/l) Water (g) Osmolality (mosm/kg water) The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable. SIMILAC HUMAN MILK FORTIFIER SPECIAL CARE 30 OMEGA-3 AND OMEGA-6 Liquid Human Milk Fortifier For preterm or low-birth-weight infants

27 Nutrient Values of Fortified Human Milk (FHM) + Similac Human Milk Fortifier Special Care 30 Omega-3 and Omega-6 (SHMF SC30) Per 100 Cal ENERGY FHM FHM + SHMF SC30 2:1 RATIO 1:1 RATIO 1:2 RATIO Cal/30 ml ENERGY (CAL) Volume (ml) PROTEIN (g) FAT (g) Linoleic acid (g) CARBOHYDRATE (g) VITAMINS Vitamin A (IU) Vitamin D3 (IU) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) Potassium (mg [mmol]) Chloride (mg [mmol]) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) OTHER CHARACTERISTICS PRSL (mosm/l) Water (g) Osmolality (mosm/kg water) PER 100 ml ENERGY FHM FHM + SHMF SC30 2:1 RATIO 1:1 RATIO 1:2 RATIO Cal/30 ml ENERGY (CAL) Volume (ml) PROTEIN (g) FAT (g) Linoleic acid (g) CARBOHYDRATE (g) VITAMINS Vitamin A (IU) Vitamin D3 (IU) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) Potassium (mg [mmol]) Chloride (mg [mmol]) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) OTHER CHARACTERISTICS PRSL (mosm/l) Water (g) Osmolality (mosm/kg water) Similac Human Milk Fortifier + Preterm Human Milk (1 packet + 25 ml of human milk) REFERENCES: 1. Adamkin DH, Radmacher PG. Fortification of Human Milk in Very Low Birth Weight Infants (VLBW <1500 g Birth Weight). Clin Perinatol (2014); 41: Government of Canada. Preparing and handling powdered infant formula. Accessed at Accessed on July 24, Robbins ST, Myers R (eds). Infant Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. 2nd ed. American Dietetic Assocation. Pediatric Nutrition Practice Group Lewis J et al. J Invest Med. 2010;58(2):435. Abstract Klein CJ. J Nutr 2002;132:1395S-1577S. 6. Koletzko B, Poindexter B, Uauy R (eds): Nutritional Care of Preterm Infants: Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2014, vol 110, pp Canadian Food Inspection Agency: GUIDE TO FOOD LABELLING AND ADVERTISING Health Claims. Chapter 8. Retrieved from: ?chap=8. Accessed on Sept.15, Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p

28 SIMILAC HUMAN MILK FORTIFIER For preterm or low-birth-weight infants INDICATIONS FOR USE For preterm or low-birth-weight infants nourished with human milk that requires fortification to meet elevated nutrient requirements. Intended as a nutritional supplement to add to human milk. For oral or tube feeding use. Safety precautions: Use under medical supervision. For infants who are premature, low-birth-weight or with a weakened immune system, sterile liquids are preferred. 1 This product is not sterile and should only be used as directed by a health care professional. Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk. Once enteral feeding is well-established, Similac Human Milk Fortifier can be added to human milk. Not intended for feeding low-birth-weight infants after they reach a weight of 3600 g (approximately 8 lb) unless otherwise directed by a health care professional. Add only to human milk do not add water. Not for parenteral use. FEATURES AND BENEFITS Peer-reviewed studies have demonstrated: - Normal weight, length and head circumference gains in preterm infants. 2 - Preserved antibacterial activity of human milk against Escherichia coli, Staphylococcus, Group B Streptococcus, and Enterobacter sakazakii (now Cronobacter sakazakii). 3 Low iron content provides flexibility to add iron as needed. Mixes readily with human milk. Small, convenient packaging. TECHNICAL DATA Preterm Human Milk + Similac Human Milk Fortifier (50 ml g powder) Caloric density (Cal/mL) 0.73 Protein (% of total energy) 10 Fat (% of total energy) 49 Carbohydrate (% of total energy) 41 Total Cal:g nitrogen ratio 250:1 Non-protein Cal:g nitrogen ratio 57:43 Water (g/l) 867 Osmolality (mosm/kg water) 343 Renal solute load (mosm/l) Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder Similac Human Milk Fortifier 50 x 0.9 g 3 inner cartons/ packets/ case inner carton 28

29 PREPARATION The health of the infant depends on carefully following the directions for preparation and use. Proper hygiene, handling and storage are important when preparing infant feedings. Similac Human Milk Fortifier Mixing Chart Additional Cal desired Preterm Human Milk Similac Milk Fortifier Human For initiation 2 Cal/30 ml 50 ml 1 packet (0.9 g) For full strength feeding 4 Cal/30 ml 25 ml 1 packet (0.9 g) 1. It is recommended that human milk be fortified just prior to feeding Shake container of human milk. If frozen, thaw according to hospital procedure. 3. To promote optimal mixing, human milk should be slightly above room temperature before adding the fortifier. 4. Pour desired quantity of human milk into sterile container; add Similac Human Milk Fortifier (as per mixing chart). 5. Shake gently and feed. 6. Bottle feeding: Discard any remaining product in the bottle within 1 hour after feeding begins. Tube feeding: Hang for no more than 4 hours. 5 STORAGE Cover and refrigerate unused fortified human milk immediately and use within 24 hours. Store unopened packets at room temperature; avoid extreme temperatures. ENERGY Per 1 packet (0.9 g) Per 4 packets (3.6 g) ENERGY (Cal [kj]) 3.5 (14.7) 14 (59) PROTEIN (g) Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) - - Carnitine (mg) - - Nonfat milk, whey protein concentrate FAT (g) Linoleic acid (g) - - MCT oil CARBOHYDRATE (g) Corn syrup solids VITAMINS Vitamin A (RE [IU]) 47 (155) 186 (620) Vitamin D3 (mcg [IU]) 0.75 (30) 3 (120) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 3.8 (0.16) 15 (0.65) Potassium (mg [mmol]) 15.8 (0.4) 63 (1.62) Chloride (mg [mmol]) 9.5 (0.27) 38 (1.07) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) - - Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) - - Molybdenum (mg) - - INGREDIENTS Similac Human Milk Fortifier, Powder: Nonfat milk, whey protein concentrate, corn syrup solids, medium chain triglycerides (modified coconut oil and/or palm kernel oil), calcium phosphate, potassium citrate, ascorbic acid, magnesium chloride, soy lecithin, sodium chloride, zinc sulphate, m-inositol, niacinamide, sodium citrate, d-α-tocopheryl acetate, calcium pantothenate, ferrous sulphate, vitamin A palmitate, cupric sulphate, riboflavin, thiamine chloride hydrochloride, pyridoxine hydrochloride, vitamin D3, biotin, folic acid, manganese sulphate, phylloquinone, cyanocobalamin, sodium selenate. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC HUMAN MILK FORTIFIER For preterm and low-birth-weight infants

30 Preterm Human Milk (PTHM) + Similac Human Milk Fortifier Per 100 Cal ENERGY Preterm Human Milk PTHM + Similac Human Milk Fortifier 50 ml + 1 packet 25 ml + 1 packet ENERGY (Cal) Volume (ml) PROTEIN (g) % of total energy Preterm human milk Preterm human milk, nonfat milk, whey protein concentrate FAT (g) % of total energy Preterm human milk Preterm human milk, medium chain triglycerides Linoleic acid (g) CARBOHYDRATE (g) % of total energy Lactose Lactose, corn syrup solids VITAMINS Vitamin A (RE [IU]) 174 (581) 283 (944) 374 (1245) Vitamin D3 (mcg [IU]) 0.08 (3) 2.1 (84) 3.75 (150) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 37 (1.6) 44 (1.9) 49 (2.1) Potassium (mg [mmol]) 85 (2.2) 119 (3.1) 148 (3.8) Chloride (mg [mmol]) 82 (2.3) 100 (2.8) 115 (3.2) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) OTHER CHARACTERISTICS PRSL (mosm/l) Water (g) Osmolality (mosm/kg water) Per 1000 ml ENERGY Preterm Human Milk PTHM + Similac Human Milk Fortifier 50 ml + 1 packet 25 ml + 1 packet ENERGY (Cal) Volume (ml) PROTEIN (g) % of total energy Preterm human milk Preterm human milk, nonfat milk, whey protein concentrate FAT (g) % of total energy Preterm human milk Preterm human milk, medium chain triglycerides Linoleic acid (g) CARBOHYDRATE (g) % of total energy Lactose Lactose, corn syrup solids VITAMINS Vitamin A (RE [IU]) 1170 (3899) 2072 (6906) 2950 (9834) Vitamin D3 (mcg [IU]) 0.5 (20) 15.3 (612) 29.7 (1188) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg)

31 Per 1000 ml MINERALS Preterm Human Milk PTHM + Similac Human Milk Fortifier 50 ml + 1 packet 25 ml + 1 packet Sodium (mg [mmol]) 248 (10.8) 319 (13.9) 388 (16.9) Potassium (mg [mmol]) 570 (14.6) 874 (22.4) 1169 (30) Chloride (mg [mmol]) 550 (15.5) 730 (20.6) 906 (25.6) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) OTHER CHARACTERISTICS PRSL (mosm/l) Water (g) Osmolality (mosm/kg water) NUTRITIONAL INFORMATION The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable. 6 Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium. 7 REFERENCES: 1. Government of Canada. Preparing and handling powdered infant formula. Accessed at healthycanadians.gc.ca/eating-nutrition/safety-salubrite/formula-nourrisson-eng.php. Accessed on July 24, Barrett-Reis B, Hall RT, Schanler RJ et al. Pediatrics 2000; 106: Chan GM. J Perinatol 2003;23: Reali A, Greco F, Fanaro S et al. Early Hum Dev 2010;86:S Robbins ST, Myers R (eds). Infant Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. 2nd ed. American Dietetic Assocation. Pediatric Nutrition Practice Group Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy. 31

32 LIQUIPROTEIN Extensively Hydrolyzed Protein INDICATIONS FOR USE For use as a protein fortifier with human milk or infant formula. For preterm and low-birth-weight infants with increased protein needs. Safety precautions: Not for use as a sole source of nutrition. Use as directed by a health care professional. Do not attach nipple or feed directly. If signs of intolerance develop, slow feeding or discontinue. Not for parenteral use. FEATURES AND BENEFITS A commercially sterile, extensively hydrolyzed liquid protein modular; same trusted casein hydrolysate used in Similac Alimentum. Eliminates the need for protein powder mixing and meets Health Canada 1 and other expert body recommendations 2 to reduce the risk of contamination. Allows for customized protein intake. Safe for preterm infants study 3 indicates good feeding tolerance and growth when fed full strength fortified human milk with the addition of LiquiProtein. Minimal impact on osmolality; 1 ml contributes ~12 mosm/kg water when 100 ml feeding is prepared; osmolality comparable to using Similac Human Milk Fortifier. Black cap for easy product identification and distinguishing features on label designed to stand out from infant formulas. Lactose-free. TECHNICAL DATA Ready to mix Caloric density (Cal/mL) 0.67 Protein (% of total energy) 100 Fat (% of total energy) 0 Carbohydrate (% of total energy) 0 Total Cal:g nitrogen ratio 25:1 Non-protein Cal:g nitrogen ratio Water (g/l) 810 Displacement 1 ml will displace 1 ml of feeding Osmolality Preterm infants Osmolality per 100 ml feeding 1 ml contributes ~12 mosm/kg water Osmolality as commonly fed mosm/kg water Renal solute load (mosm/l) - Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal No No AVAILABILITY Ready to mix 62317X31 (Pediatric) LiquiProtein 54-mL plastic 48/case bottles 25 ml human milk + 1 packet Similac Human Milk Fortifier + 1 ml LiquiProtein. Osmolality when supplementing 25 ml of preterm human milk with an equivalent of 0.25 g of protein from the following products: 1 packet Similac Human Milk Fortifier: 385 mosm/kg water; 1.5 ml LiquiProtein : 370 mosm/kg water. Not suitable for infants with galactosemia. 1 to 6 ml of LiquiProtein + human milk, fortified human milk, or formula; total volume of 100 ml. 32

33 PREPARATION The health of the infant depends on carefully following the directions for preparation and use. Proper hygiene, handling and storage are important when preparing infant feedings. Do not add water 1. Pour LiquiProtein into a medicine cup. 2. Using a single use oral syringe, draw up volume specified by a health care professional. 3. Dispense into measured human milk or formula and mix gently. Pour desired amount of mixture into feeding container. STORAGE Store unopened at room temperature; avoid extreme temperatures. Once opened, refrigerate and use within 72 hours. When mixed with human milk or formula, cover and refrigerate unused mixture immediately. Use within 24 hours or according to normal hospital procedure. For preterm infants who are tube-fed, fortified milk can remain safely at room temperature (25 C) for up to 4 hours. 2 ENERGY Per 6 ml Per 54 ml ENERGY (Cal [kj]) 4 (17) 35 (149) PROTEIN (g) 1 9 % of total energy 100 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Casein hydrolysate MINERALS Sodium (mg) 5 50 INGREDIENTS LiquiProtein, ready-to-mix liquid: Water, casein hydrolysate (derived from milk). CONTAINS: Priority food allergens: Milk ingredients. NUTRITIONAL INFORMATION Other inherent minerals may be present in trace amounts. LiquiProtein contains the same trusted casein hydrolysate used in Similac Alimentum. REFERENCES: 1. Government of Canada. Healthy Canadians: Preparing and Handling Powdered Infant Formula 2011 [cited October 2017]. Available from: 2. Robbins ST, Meyers R. Pediatric Nutrition Practice Group, Academy of Nutrition and Dietetics. Infant Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. 2nd ed. 2011: American Dietetic Association. 3. Shakeel F et al. Tolerance and growth in preterm infants by optimizing protein in human milk with hydrolyzed liquid protein fortifier [ABSTRACT]. Journal of Pediatric Gastroenterology and Nutrition 2015;61(Suppl 2):S112. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. LIQUIPROTEIN Extensively Hydrolyzed Protein

34 SIMILAC SPECIAL CARE 20 OMEGA-3 AND OMEGA-6 DHA- and ARA-enriched formula For preterm infants INDICATIONS FOR USE For infants who are born prematurely and have additional nutrient needs that were not met in-utero. Recommended until infant reaches 3600 g (approximately 8 lb). For oral or tube feeding use. Safety precautions: Use under medical supervision. Not intended for feeding preterm infants after they reach a weight of 3600 g, or as directed by a physician. If signs of intolerance develop, slow feeding or discontinue. Not for parenteral use. FEATURES AND BENEFITS Suitable for mixing to a variety of different caloric densities using the Similac Liqui-Mix System. Higher levels of protein, electrolytes, vitamins and minerals per 100 Cal than standard term formula to provide preterm babies with the nutrients they need for growth and development. Calcium and phosphorus at concentrations and ratio (1.8:1) that support intrauterine accretion rates. 1 Approximately 2 mg iron/kg body weight per day when fed at 120 Cal/kg/day. 39% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 2 DHA, an Omega-3 fatty acid that supports the normal physical development of the brain and eyes. 3 Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 12.0 Fat (% of total energy) 46.8 Carbohydrate (% of total energy) 41.2 Total Cal:g nitrogen ratio 213:1 Non-protein Cal:g nitrogen ratio 187:1 Water (g/l) 900 Osmolality (mosm/kg water) 238 Renal solute load (mosm/l) 180 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Special Care mL plastic 48/case Omega-3 and Omega-6 bottles Similar to other infant formulas. REFERENCES: 1. Mize CE et al. Am J Clin Nutr 1995;62: Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton Canadian Food Inspection Agency: Health Claims Nutrient Function Claims. Last modified on [Accessed online on ]. 34

35 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 68 (284) 100 (418) 40 (168) PROTEIN (g) % of total energy 12.0 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry or condensed skim milk, whey protein concentrate FAT (g) % of total energy 46.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 7.0:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) (MCT oil) Medium chain triglycerides, soy oil, coconut oil, high oleic sunflower oil, ARA and DHA MCT oil (% of total fats) 39.1 CARBOHYDRATE (g) % of total energy 41.2 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, lactose, dry or condensed skim milk Acesulfame-potassium (mg) Sucralose (mg) NUTRITIONAL INFORMATION VITAMINS Vitamin A (RE [IU]) 140 (467) 206 (687) 83 (276) Vitamin D3 (mcg [IU]) 2.6 (102) 3.8 (150) 1.5 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 29 (1.26) 43 (1.85) 17 (0.74) Potassium (mg [mmol]) 94.5 (2.42) (3.56) 55.8 (1.43) Chloride (mg [mmol]) 55 (1.55) 81 (2.28) 32 (0.92) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS Similac Special Care 20 Omega-3 and Omega-6, Ready to use: Water, corn maltodextrin, dry or condensed skim milk, lactose, medium chain triglycerides (modified coconut and/or palm kernel oils), whey protein concentrate, soy oil, coconut oil, high oleic sunflower oil, calcium phosphate, sodium citrate, ascorbic acid, M. alpina oil*, C. cohnii oil**, soy lecithin, monoglycerides, carrageenan, magnesium chloride, potassium chloride, calcium carbonate, m-inositol, potassium citrate, potassium hydroxide, ferrous sulphate, taurine, choline bitartrate, L-carnitine, choline chloride, dl-α-tocopheryl acetate, cytidine 5'-monophosphate, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, calcium d-pantothenate, niacinamide, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, folic acid, phylloquinone, manganese sulphate, sodium selenite, biotin, vitamin D3, cyanocobalamin. May contain sodium chloride, potassium phosphate. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC SPECIAL CARE 20 OMEGA-3 AND OMEGA-6 DHA- and ARA-enriched formula For preterm infants

36 SIMILAC SPECIAL CARE 24 OMEGA-3 AND OMEGA-6 Hypercaloric, DHA- and ARA-enriched formula For preterm infants INDICATIONS FOR USE For infants who are born prematurely and have additional nutrient needs that were not met in-utero. Recommended until infant reaches 3600 g (approximately 8 lb). For oral or tube feeding use. Safety precautions: Use under medical supervision. Not intended for feeding preterm infants after they reach a weight of 3600 g, or as directed by a physician. If signs of intolerance develop, slow feeding or discontinue. Not for parenteral use. FEATURES AND BENEFITS Suitable for mixing to a variety of different caloric densities using the Similac Liqui-Mix System. Increased caloric density: provides 81 Cal per 100 ml (24 Cal/30 ml). Higher levels of protein, electrolytes, vitamins and minerals per 100 Cal than standard term formula to provide preterm babies with the nutrients they need for growth and development. Calcium and phosphorus at concentrations and ratio (1.8:1) that support intrauterine accretion rates. 1 Approximately 2 mg iron/kg body weight per day when fed at 120 Cal/kg/day. 39% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 2 DHA, an Omega-3 fatty acid that supports the normal physical development of the brain and eyes. 3 Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.81 Protein (% of total energy) 12.0 Fat (% of total energy) 46.8 Carbohydrate (% of total energy) 41.2 Total Cal:g nitrogen ratio 213:1 Non-protein Cal:g nitrogen ratio 187:1 Water (g/l) 880 Osmolality (mosm/kg water) 300 Renal solute load (mosm/l) 210 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Special Care mL plastic 48/case Omega-3 and Omega-6 bottles Similar to other infant formulas. REFERENCES: 1. Mize CE et al. Am J Clin Nutr 1995;62: Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton Canadian Food Inspection Agency: Health Claims Nutrient Function Claims. Last modified on [Accessed online on ]. 36

37 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 81 (339) 100 (418) 48 (201) PROTEIN (g) % of total energy 12.0 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry or condensed skim milk, whey protein concentrate FAT (g) % of total energy 46.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 7.0:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) (MCT oil) Medium chain triglycerides, soy oil, coconut oil, high oleic sunflower oil, ARA and DHA MCT oil (% of total fats) 39.2 CARBOHYDRATE (g) % of total energy 41.2 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, lactose, dry or condensed skim milk Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 167 (556) 206 (687) 98 (328) Vitamin D3 (mcg [IU]) 3.05 (122) 3.77 (151) 1.80 (72) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 35 (1.52) 43 (1.88) 21 (0.90) Potassium (mg [mmol]) 113 (2.90) 140 (3.58) 67 (1.71) Chloride (mg [mmol]) 66 (1.86) 81 (2.30) 39 (1.10) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Special Care 24 Omega-3 and Omega-6, Ready to use: Water, corn maltodextrin, dry or condensed skim milk, lactose, medium chain triglycerides (modified coconut and/or palm kernel oils), whey protein concentrate, soy oil, coconut oil, high oleic sunflower oil, calcium phosphate, sodium citrate, ascorbic acid, M. alpina oil*, C. cohnii oil**, soy lecithin, monoglycerides, potassium chloride, magnesium chloride, carrageenan, potassium citrate, calcium carbonate, m-inositol, potassium hydroxide, ferrous sulphate, taurine, choline bitartrate, choline chloride, L-carnitine, dl-α-tocopheryl acetate, cytidine 5'-monophosphate, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, calcium d-pantothenate, niacinamide, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, folic acid, phylloquinone, manganese sulphate, sodium selenite, biotin, vitamin D3, cyanocobalamin. May contain sodium chloride, potas sium phosphate. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, and other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC SPECIAL CARE 24 OMEGA-3 AND OMEGA-6 Hypercaloric, DHA- and ARA-enriched formula For preterm infants

38 SIMILAC SPECIAL CARE 24 HIGH PROTEIN OMEGA-3 AND OMEGA-6 High-protein, hypercaloric DHAand ARA-enriched formula For preterm infants INDICATIONS FOR USE For infants who are born prematurely and have additional nutrient needs that were not met in-utero and who may need extra protein to help support growth. Recommended until infant reaches 3600 g (approximately 8 lb). For oral or tube feeding use. Safety precautions: Use under medical supervision. Not intended for feeding preterm infants after they reach a weight of 3600 g, or as directed by a physician. Do not exceed a protein intake of: g/kg/day for infants up to 1000 g ( g/100 Cal) g/kg/day for infants from g ( g/100 Cal) If signs of intolerance develop, slow feeding or discontinue. Not for parenteral use. FEATURES AND BENEFITS Suitable for mixing to a variety of different caloric densities using the Similac Liqui-Mix System. Specially formulated with extra vitamins, minerals, protein and calories to support the growth and development of preterm, very-low-birth-weight infants. Consistent with current expert recommendations for protein intake. 1,2 Increased caloric density; provides 81 Cal per 100 ml (24 Cal/30 ml). Approximately 10% more protein than Similac Special Care 24 (3.30 g per 100 Cal or 2.67 g/100 ml). - Studies have shown that the growth of hospitalized infants is related to protein intake. 3,4 - A convenient way to deliver additional protein in a preferred liquid form. 5 Calcium and phosphorus at concentrations and ratio (1.8:1) that support intrauterine accretion rates. 6 Approximately 2 mg iron/kg body weight per day when fed at 120 Cal/kg/day. 39% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 7 DHA, an Omega-3 fatty acid that supports the normal physical development of the brain and eyes. 8 Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.81 Protein (% of total energy) 13.2 Fat (% of total energy) 46.8 Carbohydrate (% of total energy) 40.0 Total Cal:g nitrogen ratio 189:1 Non-protein Cal:g nitrogen ratio 164:1 Water (g/l) 880 Osmolality (mosm/kg water) 296 Renal solute load (mosm/l) 225 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Special Care mL 48/case High Protein Omega-3 and plastic bottles Omega-6 Similar to other infant formulas. REFERENCES: 1. Klein CJ. J Nutr 2002;132:1395S-577S. 2. Premji SS, Fenton TR, Sauve RS. Higher versus lower protein intake in formula-fed low birth weight infants. Cochrane Review (2010). 3. Kashyap S et al. Pediatr Res 1994;35(6): Kashyap S et al. J Pediatr 1988;113: Health Canada. Accessed on February 28, Mize CE et al. Am J Clin Nutr 1995;62: Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton Canadian Food Inspection Agency: Health Claims Nutrient Function Claims. Last modified on [Accessed online on ] 38

39 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 81 (339) 100 (418) 48 (200) PROTEIN (g) % of total energy 13.2 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry or condensed skim milk, whey protein concentrate FAT (g) % of total energy 46.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 7.0:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) MCT oil, soy oil, coconut oil, high oleic sunflower oil, ARA and DHA MCT oil (% of total fats) 39.3 CARBOHYDRATE (g) % of total energy 40.0 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, dry or condensed skim milk, lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 167 (556) 206 (687) 98 (328) Vitamin D3 (mcg [IU]) 3.05 (122) 3.75 (150) 1.80 (72) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 35 (1.52) 43 (1.88) 21 (0.90) Potassium (mg [mmol]) 118 (3.03) 146 (3.74) 70 (1.79) Chloride (mg [mmol]) 66 (1.86) 81 (2.30) 39 (1.10) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Special Care 24 High Protein Omega-3 and Omega-6, Ready to use: Water, corn maltodextrin, dry skim milk, whey protein concentrate, medium chain triglycerides (modified coconut and/or palm kernel oils), lactose, soy oil, coconut oil, high oleic sunflower oil, calcium phosphate, sodium citrate, ascorbic acid, M. alpina oil *, C. cohnii oil **, soy lecithin, monoglycerides, carrageenan, potassium citrate, magnesium chloride, m-inositol, potassium chloride, potassium hydroxide, calcium carbonate, ferrous sulphate, taurine, choline bitartrate, choline chloride, L-carnitine, dl-α-tocopheryl acetate, cytidine 5'-monophosphate, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, calcium d-pantothenate, niacinamide, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, folic acid, phylloquinone, manganese sulphate, sodium selenite, biotin, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC SPECIAL CARE 24 HIGH PROTEIN OMEGA-3 AND OMEGA-6 Hypercaloric, DHA- and ARA-enriched formula For preterm infants

40 SIMILAC NEOSURE DHA- and ARA-enriched formula For preterm infants 0-12 months corrected age INDICATIONS FOR USE For preterm infants being discharged home. For breastfed infants, supplementing with feedings of prepared post-discharge formula is recommended as a strategy for meeting additional nutrient requirements. 1 Term formula (such as Similac Advance ) can be introduced once the baby has achieved adequate catch-up growth: - The American Academy of Pediatrics recommends that the use of a postdischarge formula should be individualized to optimize the growth trajectory of the infant over the first year. 1 - Bhatia (2005) suggests stopping at 4-6 months corrected age if all growth parameters are >25 th percentile. 2 For oral or tube feeding use. Safety precautions: Not for parenteral use. Use under medical supervision. FEATURES AND BENEFITS 74 Cal per 100 ml (22 Cal per 30 ml). Supports catch-up growth during the first year: 3 - Increased calories for growth. - 33% more protein to help meet higher protein requirements. - Approximately 35% more calcium & phosphorus to support baby s growing bones. Peer-reviewed studies evaluating the use of preterm post-discharge formula compared to term infant formula in preterm infants have demonstrated: - Greater gains in weight, length, and head circumference compared to those fed term formula. 3 - An increase in lean body mass rather than fat mass: - More rapid and complete catch-up growth with an increase in lean body mass rather than fat mass. 4 - Increase in lean body mass with no significant increase in skinfold thickness. 5 DHA, an omega-3 fatty acid, to support the normal physical development of the brain and eyes. 6 Approximately 25% of fat as medium-chain triglycerides, an easily-digested and well-absorbed fat source. 7 Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.74 Protein (% of total energy) 11 Fat (% of total energy) 49 Carbohydrate (% of total energy) 40 Total Cal:g nitrogen ratio 228:1 Non-protein Cal:g nitrogen ratio 203:1 Water (g/l) 890 Osmolality (mosm/kg water) 250 Renal solute load (mosm/l) 187 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder Similac Neosure 363-g cans 6/case Similac Neosure Powder Mixing Chart Caloric Density (Cal/30 ml) Unpacked, level scoops # Water (ml) Approximate Yield ## (ml) (standard) # Use only scoop provided in the can. ## Calculated using displacement volume and rounded to the nearest whole number. 40

41 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 513 (2146) 74.4 (311) 100 (418) PROTEIN (g) % of total energy 11 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) SIMILAC NEOSURE DHA- and ARA-enriched formula For preterm infants 0-12 months corrected age Skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 49 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 8.24:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Soy oil, high oleic safflower oil, MCT oil, coconut oil, ARA and DHA MCT oil (% of total fats) 24.9 CARBOHYDRATE (g) % of total energy 40 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup solids, lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 710 (2367) 103 (343) 138 (461) Vitamin D3 (mcg [IU]) 9 (359) 1.3 (52) 1.8 (70) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 173 (7.52) 25 (1.09) 34 (1.47) Potassium (mg [mmol]) 732 (18.77) 106 (2.72) 143 (3.66) Chloride (mg [mmol]) 386 (10.89) 56 (1.58) 75 (2.12) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS Similac Neosure, Powder: Skim milk, corn syrup solids, lactose, soy oil, high oleic safflower oil, medium chain triglycerides (modified coconut and/or palm kernel oils), whey protein concentrate, coconut oil, whey protein hydrolysate, calcium phosphate, ascorbic acid, M. alpina oil*, calcium carbonate, m-inositol, C. cohnii oil**, potassium citrate, magnesium chloride, potassium chloride, taurine, ferrous sulphate, choline bitartrate, choline chloride, L-carnitine, ascorbyl palmitate, cytidine 5'-monophosphate, d-α-tocopheryl acetate, disodium guanosine 5'-monophosphate, zinc sulphate, disodium uridine 5'-monophosphate, niacinamide, adenosine 5'-monophosphate, mixed tocopherols, calcium d-pantothenate, cupric sulphate, thiamine chloride hydrochloride, vitamin A palmitate, riboflavin, pyridoxine hydrochloride, β-carotene, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, other soy components. Compared to Similac Advance (per 100 Cal). Similac Neosure formulation used in this study may differ slightly from current Similac Neosure product. Compared to infants fed term formula or a combination of preterm postdischarge and term formula. Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. American Academy of Pediatrics Committee on Nutrition. Nutritional Needs of the Preterm Infant In: Kleinman RE, Greer FR, eds. Pediatric Nutrition. 7th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2014: Bhatia J. J Perinatol 2005;25(suppl 2):S15-S Carver JD, Wu PYK, Hall RT, et al. Pediatrics 2001;107: Cooke RJ, Griffin IJ, and McCormick K. Pediatr Res 2010;67: Lucas A, Fewtrell MS, Morley R, et al. Pediatrics 2001;108: Canadian Food Inspection Agency: GUIDE TO FOOD LABELLING AND ADVERTISING Health Claims. Chapter 8. Retrieved from: health-claims/eng/ / ?chap=8. Accessed in January Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. NUTRITIONAL INFORMATION

42 SIMILAC NEOSURE OMEGA-3 AND OMEGA-6 DHA- and ARA-enriched formula For preterm infants 0-12 months corrected age INDICATIONS FOR USE For preterm infants who are being discharged home. For breastfed infants, supplementing with feedings of prepared post-discharge formula is recommended as a strategy for meeting additional nutrient requirements. 1 Term formula (such as Similac Advance ) can be introduced once the baby has achieved adequate catch-up growth: - The American Academy of Pediatrics recommends that the use of a post-discharge formula should be individualized to optimize the growth trajectory of the infant over the first year. 1 - Bhatia (2005) suggests stopping at 4-6 months corrected age if all growth parameters are >25 th percentile. 2 For oral or tube feeding use. Safety precautions: Not for parenteral use. Use under medical supervision. FEATURES AND BENEFITS 74 Cal per 100 ml (22 Cal per 30 ml). Supports catch-up growth during the first year: 3 - Increased calories for growth. - 33% more protein to help meet higher protein requirements. - Approximately 35% more calcium and phosphorus to support baby s growing bones. Peer-reviewed studies evaluating the use of preterm post-discharge formula compared to term infant formula in preterm infants have demonstrated: - Greater gains in weight, length, and head circumference compared to those fed term formula. 3 - An increase in lean body mass rather than fat mass: - More rapid and complete catch-up growth with an increase in lean body mass rather than fat mass. 4 - Increase in lean body mass with no significant increase in skinfold thickness. 5 DHA an omega-3 fatty acid, and ARA an omega-6 fatty acid, to support the normal physical development of the brain and eyes. 6 Approximately 25% of fat as medium-chain triglycerides, an easilydigested and well-absorbed fat source. 7 Easy to digest. TECHNICAL DATA Ready to (use) Caloric density (Cal/mL) 0.74 Protein (% of total energy) 11.2 Fat (% of total energy) 48.4 Carbohydrate (% of total energy) 40.4 Total Cal:g nitrogen ratio 223:1 Non-protein Cal:g nitrogen ratio 198:1 Water (g/l) 890 Osmolality (mosm/kg water) 250 Renal solute load (mosm/l) 187 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Neosure 59-mL plastic 48/case Omega-3 and Omega-6 bottles 42

43 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 74 (311) 100 (418) 44 (183) PROTEIN (g) % of total energy 11.2 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry or condensed skim milk, whey protein concentrate FAT (g) % of total energy 48.4 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 7.0:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Soy oil, coconut oil, MCT oil, ARA and DHA MCT oil (% of total fats) 24.3 CARBOHYDRATE (g) % of total energy 40.4 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup solids, lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 103 (342) 138 (460) 61 (202) Vitamin D3 (mcg [IU]) 1.3 (52) 1.8 (70) 0.77 (31) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 25 (1.09) 33 (1.43) 15 (0.64) Potassium (mg [mmol]) 106 (2.72) 142 (3.64) 63 (1.60) Chloride (mg [mmol]) 56 (1.58) 75 (2.12) 33 (0.93) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Neosure Omega-3 and Omega-6, Ready to use: Water, dry or condensed skim milk, corn syrup solids, soy oil, lactose, coconut oil, whey protein concentrate, medium chain triglycerides (modified coconut and/or palm kernel oils), potassium citrate, ascorbic acid, M. alpina oil*, C. cohnii oil**, monoglycerides, soy lecithin, calcium carbonate, calcium phosphate, m-inositol, magnesium chloride, potassium hydroxide, carrageenan, taurine, choline chloride, ferrous sulphate, potassium chloride, choline bitartrate, L-carnitine, d-α-tocopheryl acetate, cytidine 5'-monophosphate, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, niacinamide, adenosine 5'-monophosphate, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, b-carotene, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. May contain potassium phosphate, sodium chloride. Contains: milk, soy. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, lactose, other soy components. Compared to Similac Advance Omega-3 and Omega-6 (per 100 Cal). Similac Neosure used up to 12 months corrected age. Formulation used in this study may differ slightly from current Similac Neosure Omega-3 and Omega-6 product. Compared to infants fed term formula or a combination of preterm post-discharge and term formula. Similar to other infant formulas. REFERENCES: 1. American Academy of Pediatrics Committee on Nutrition. Nutritional Needs of the Preterm Infant In: Kleinman RE, Greer FR (eds). Pediatric Nutrition. 7th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2014: Bhatia J. J Perinatol 2005;25(suppl 2):S15-S Carver JD, Wu PYK, Hall RT et al. Pediatrics 2001;107: Cooke RJ, Griffin IJ, McCormick K. Pediatr Res 2010;67: Lucas A, Fewtrell MS, Morley R et al. Pediatrics 2001;108: Canadian Food Inspection Agency: GUIDE TO FOOD LABELLING AND ADVERTISING Health Claims. Chapter 8. Retrieved from: health-claims/eng/ / ?chap=8. Accessed in January Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC NEOSURE OMEGA-3 AND OMEGA-6 DHA- and ARA-enriched formula For preterm infants 0-12 months corrected age

44 NOTES:

45 TERM INFANTS Term Infants IN THIS SECTION Similac Advance Step 1 NON-GMO Similac Advance Step 1 NON-GMO (HFS) Similac Advance Step 2 NON-GMO Similac Step 2 NON-GMO Similac Step 1 NON-GMO Similac Lower Iron Step 1 NON-GMO Similac Total Comfort Step 1 NON-GMO Similac Sensitive Lactose Sensitivity Step 1 NON-GMO Similac Sensitive for babies sensitive to lactose (HFS) Continued on next page

46 TERM INFANTS Term Infants IN THIS SECTION (continued) Similac Isomil Step 1 with DHA Similac Isomil Omega-3 and Omega-6 (HFS) Similac Isomil Step 1 NON-GMO Similac 24 Omega-3 and Omega-6 (HFS) Similac Alimentum Similac Alimentum (RTU) Similac Alimentum Omega-3 and Omega-6 (HFS)

47 BREAST MILK INSPIRING OUR RESEARCH AND INNOVATION Breast milk is the first and best way parents can promote their newborn's health and development. For those who are unable to breastfeed or who decide not to, Health Canada recommends commercial infant formula as the only alternative. 1 At Abbott Nutrition, breast milk inspires all our research and innovation when it comes to infant nutritional products. Similac Advance is the perfect example of formula innovation driven by our growing understanding of human milk. The first year of life is a critical time for a baby s brain and eye development, and this growth is nutritionally responsive. 2-4 Similac Advance, our closest formula to breast milk, is available in non-gmo and is the only infant formula with an exclusive blend of DHA, lutein, and vitamin E. DHA is an omega-3 fat found in breast milk, that supports the normal physical development of the brain and eyes. 4 DHA is susceptible to damage from oxidation, which is why breast milk and the infant brain and eyes also contain antioxidants, such as lutein and vitamin E, which help protect lipids, like DHA, from oxidation Free radical DHA Lutein (antioxidant) Vitamin E (antioxidant) LUTEIN is an antioxidant found in breast milk and concentrated in the baby s brain and eyes. Recent studies show that lutein may have a role in visual and cognitive development in infants. 10 Similac Advance is the only infant formula with lutein. VITAMIN E is an antioxidant found in breast milk, but not all vitamin E is the same Similac Advance exclusively uses a form of naturally occurring vitamin E, the most abundant type found in breast milk and in the infant brain. 11,14 SIMILAC ADVANCE NUTRITION BEYOND DHA Ingredients not genetically engineered. RRR-α-tocopherol, provided as d-α-tocopheryl acetate, the most bioactive form of vitamin E. Excluding inherent sources. REFERENCES: 1. Health Canada Advisory Statement: Health Canada Raises Concerns Over Homemade Infant Formula. November Accessed April Prado EL, Dewey KG. Nutrition Reviews 2014;72(4): Brémond-Gignac D et al. Curr Opinion Ophthalmol 2011;22(Suppl):S Cetin I, Berti C, Calabrese S. Hum Reprod Update 2010;16: Canadian Food Inspection Agency. Health Claims - Nutrient Function Claims Updated in July Accessed in April Harris M.Vitam Trace Elem 2013;2(2): Zimmer JP et al. Clin Ophtalmol 2007;1: Krinsky NI et al. Ann Rev Nutr 2003;23: Vishwanathan R et al. JPGN 2014;59(5); Johnson EJ. Nutrition Reviews 2014;72(9): Moulton C et al. Natural vitamin E (RRR-alpha-tocopherol) is the predominant vitamin E stereoisomer in human milk. Abstract Stone WL et al. Am J Clin Nutr 2003;77: Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. National Academy of Sciences Kuchan MJ et al. Br J Nutr 2016;116:

48 SIMILAC ADVANCE Step 1 NON-GMO DHA- and ARA-enriched formula For term infants 0+ months of age Exclusive blend of DHA, lutein, and natural vitamin E INDICATIONS FOR USE For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS DHA, an omega-3 fatty acid that supports the normal physical development of the brain and eyes. 1 Lutein, an antioxidant found in breast milk and concentrated in the infant brain and eyes Recent studies show that lutein may have a role in visual and cognitive development. 5 Vitamin E, an antioxidant found in breast milk. 6 - Similac Advance exclusively uses natural vitamin E, 7-8 the most abundant form found in breast milk and in the infant brain. 8,9 Galactooligosaccharides (GOS), a type of oligosaccharide and dietary fibre, that: - Help promote softer stools, similar to breastfed babies May support the growth of good bacteria in the baby s intestinal tract. 11,12 Non-GMO. Easy to digest. TECHNICAL DATA Ready to use Concentrated Liquid (at standard dilution) Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio 304:1 310:1 309:1 Non-protein Cal:g nitrogen ratio 277:1 284:1 284:1 Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Advance Step mL 16/case plastic bottles Similac Advance Step mL 4x6/case plastic bottles Similac Advance Step mL reclosable 6/case plastic bottles Concentrated Liquid Similac Advance Step mL cans 12/case Powder B Similac Advance Step g containers 6/case Similac Advance Step g containers 6/case Ingredients not genetically engineered. RRR-α-tocopherol provided as d-α-tocopheryl acetate, the most bioactive form of vitamin E. Similar to other infant formulas. REFERENCES: 1. Canadian Food Inspection Agency. Health Claims - Nutrient Function Claims. Last modified on May 11, Accessed in June Zimmer JP et al. Clin Ophtalmol 2007;1: Krinsky NI et al. Ann Rev Nutr 2003;23: Vishwanathan R et al. JPGN 2014;59(5); Johnson EJ. Nutrition Reviews 2014;72(9): Moulton C et al. Natural vitamin E (RRR-alpha-tocopherol) is the predominant vitamin E stereoisomer in human milk. Abstract Stone WL et al. Am J Clin Nutr 2003;77: Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. National Academy of Sciences Kuchan MJ et al. Br J Nutr 2016;116: Williams T et al. JPGN 2014;59(5): Ben XM et al. Chin Med J (Engl) 2004;117: Ben XM et al. World J Gastroenterol 2008; 14(42):

49 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 509 (2130) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.3 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 49.9 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.71:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower or sunflower oil, soy oil, coconut oil, ARA and DHA MCT oil (% of total fats) CARBOHYDRATE (g) % of total energy 41.8 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose, dry skim milk, galactooligosaccharides Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (190) 83 (278) Vitamin D3 (mcg [IU]) 7.63 (305) 1.01 (40.5) 1.49 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 135 (5.87) 18 (0.78) 27 (1.15) Potassium (mg [mmol]) 600 (15.38) 80 (2.06) 118 (3.02) Chloride (mg [mmol]) 333 (9.39) 44 (1.25) 65 (1.85) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) Nutritional information for Similac Advance, Powder GOS is approximately 1% of the total energy and provides approximately 1.3 Cal/g. INGREDIENTS Similac Advance, Powder: Lactose, dry skim milk, high oleic vegetable oil (safflower or sunflower), soy oil, coconut oil, galactooligosaccharides (GOS), whey protein concentrate, whey protein hydrolysate, potassium citrate, calcium carbonate, M. alpina oil*, tricalcium phosphate, potassium hydroxide, C. cohnii oil**, soy lecithin, magnesium chloride, sodium chloride, choline bitartrate, ascorbic acid, L-tryptophan, ferrous sulphate, taurine, m-inositol, cytidine 5'-monophosphate, disodium guanosine 5'-monophosphate, ascorbyl palmitate, disodium uridine 5'-monophosphate, zinc sulphate, d-α-tocopheryl acetate, adenosine 5'-monophosphate, L-carnitine, mixed tocopherols, niacinamide, calcium d-pantothenate, copper sulphate, vitamin A palmitate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, lutein, folic acid, manganese sulphate, β-carotene, phylloquinone, biotin, sodium selenite, potassium iodide, vitamin D3, cyanocobalamin. Similac Advance, Concentrated Liquid: Water, lactose, dry or evaporated skim milk, high oleic vegetable oil (safflower or sunflower), soy oil, galactooligosaccharides (GOS), coconut oil, whey protein concentrate, potassium citrate, M. alpina oil*, calcium carbonate, monoglycerides, soy lecithin, C. cohnii oil**, potassium chloride, choline bitartrate, ascorbic acid, L-tryptophan, carrageenan, magnesium chloride, taurine, ferrous sulphate, m-inositol, cytidine 5'-monophosphate, citric acid, disodium guanosine 5'-monophosphate, d-α-tocopheryl acetate, zinc sulphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, niacinamide, L-carnitine, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, manganese sulphate, phylloquinone, lutein, biotin, β-carotene, sodium selenate, vitamin D3, cyanocobalamin. Similac Advance, Ready to use: Water, lactose, dry skim milk, high oleic safflower oil, soy oil, galactooligosaccharides (GOS), coconut oil, whey protein concentrate, ascorbic acid, M. alpina oil*, calcium carbonate, C. cohnii oil**, monoglycerides, soy lecithin, potassium citrate, sodium citrate, carrageenan, potassium chloride, sodium chloride, potassium phosphate dibasic, magnesium chloride, ferrous sulphate, choline bitartrate, potassium hydroxide, choline chloride, taurine, m-inositol, cytidine 5'-monophosphate, d-α-tocopheryl acetate, L-tryptophan, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, magnesium sulphate, niacinamide, L-carnitine, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, -thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, manganese sulphate, lutein, phylloquinone, β-carotene, biotin, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. NUTRITIONAL INFORMATION SIMILAC ADVANCE Step 1 NON-GMO DHA- and ARA-enriched formula For term infants 0+ months of age

50 SIMILAC ADVANCE Step 1 NON-GMO DHA- and ARA-enriched formula For term infants 0+ months of age Exclusive blend of DHA, lutein, and natural vitamin E INDICATIONS FOR USE For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS DHA, an omega-3 fatty acid that supports the normal physical development of the brain and eyes. 1 Lutein, an antioxidant found in breast milk and concentrated in the infant brain and eyes Recent studies show that lutein may have a role in visual and cognitive development. 5 Vitamin E, an antioxidant found in breast milk. 6 - Similac Advance exclusively uses natural vitamin E, 7-8 the most abundant form found in breast milk and in the infant brain. 8,9 Galactooligosaccharides (GOS), a type of oligosaccharide and dietary fibre, that: - Help promote softer stools, similar to breastfed babies May support the growth of good bacteria in the baby s intestinal tract. 11,12 Non-GMO. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 8.3 Fat (% of total energy) 49.3 Carbohydrate (% of total energy) 42.4 Total Cal:g nitrogen ratio 304:1 Non-protein Cal:g nitrogen ratio 277:1 Water (g/l) 900 Osmolality (mosm/kg water) 306 Renal solute load (mosm/l) 127 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use (Institutional/Hospital) Similac Advance Step 1 59-mL plastic 48/case bottles (Retail) Similac Advance Step 1 8 x 59-mL plastic 6/case bottles 66935B71 Similac Advance Step 1 24 x 59-mL plastic 4/case bottles Ingredients not genetically engineered. RRR-α-tocopherol provided as d-α-tocopheryl acetate, the most bioactive form of vitamin E. Similar to other infant formulas. REFERENCES: 1. Canadian Food Inspection Agency. Health Claims - Nutrient Function Claims. Last modified on May 11, Accessed in June Zimmer JP et al. Clin Ophtalmol 2007;1: Krinsky NI et al. Ann Rev Nutr 2003;23: Vishwanathan R et al. JPGN 2014;59(5); Johnson EJ. Nutrition Reviews 2014;72(9): Moulton C et al. Natural vitamin E (RRR-alpha-tocopherol) is the predominant vitamin E stereoisomer in human milk. Abstract Stone WL et al. Am J Clin Nutr 2003;77: Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. National Academy of Sciences Kuchan MJ et al. Br J Nutr 2016;116: Williams T et al. JPGN 2014;59(5): Ben XM et al. Chin Med J (Engl) 2004;117: Ben XM et al. World J Gastroenterol 2008; 14(42):

51 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 67.6 (283) 100 (419) 40 (167) PROTEIN (g) % of total energy 8.3 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Threonine (mg) Tryptophan (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry skim milk, whey protein concentrate FAT (g) % of total energy 49.3 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 10.0:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, soy oil, coconut oil, ARA and DHA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.4 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose, galactooligosaccharides Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 61 (203) 90 (300) 36 (120) Vitamin D3 (mcg [IU]) 0.9 (35) 1.3 (52) 0.5 (21) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 18 (0.78) 27 (1.16) 11 (0.46) Potassium (mg [mmol]) 79 (2.03) 117 (3.00) 47 (1.20) Chloride (mg [mmol]) 40 (1.13) 59 (1.67) 24 (0.67) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION GOS is approximately 1% of the total energy and provides approximately 1.3 Cal/g. INGREDIENTS Similac Advance, Ready to use: Water, lactose, dry skim milk, high oleic safflower oil, soy oil, galactooligosaccharides (GOS), coconut oil, whey protein concentrate, potassium citrate, calcium carbonate, ascorbic acid, *M. alpina oil, **C. cohnii oil, monoglycerides, soy lecithin, sodium citrate, carrageenan, potassium chloride, sodium chloride, potassium phosphate dibasic, magnesium chloride, ferrous sulphate, choline bitartrate, potassium hydroxide, choline chloride, taurine, m-inositol, cytidine 5'-monophosphate, d-α-tocopheryl acetate, L-tryptophan, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, niacinamide, L-carnitine, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, lutein, manganese sulphate, phylloquinone, β-carotene, potassium iodide, d-biotin, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Lactose, other soy components, coconut oil, citric acid. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ADVANCE Step 1 NON-GMO DHA- and ARA-enriched formula For term infants 0+ months of age

52 SIMILAC ADVANCE Step 2 NON-GMO DHA- and ARA-enriched formula For infants and toddlers 6 to 24 months of age Exclusive blend of DHA, lutein, and natural vitamin E INDICATIONS FOR USE Transition formula for healthy, term infants who are 6 months or older. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Specially formulated to help bridge the nutritional intake gaps that can be associated with the transition to table foods. Calcium enriched (50% more calcium than Similac Advance Step 1) to support growing infants. DHA, an omega-3 fatty acid that supports the normal physical development of the brain and eyes. 1 Lutein, an antioxidant found in breast milk and concentrated in the infant s brain and eyes Recent studies show that lutein may have a role in visual and cognitive development. 5 Vitamin E, an antioxidant found in breast milk. 6 - Similac Advance exclusively uses natural vitamin E 7-8, the most abundant form found in breast milk and in the infant brain. 8,9 Galactooligosaccharides (GOS), a type of oligosaccharide and dietary fibre, that: - Help promote softer stools, similar to breastfed babies May support the growth of good bacteria in the infant s intestinal tract. 11,12 Non-GMO. Easy to digest. TECHNICAL DATA Concentrated Liquid (at standard dilution) Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio 310:1 309:1 Non-protein Cal:g nitrogen ratio 284:1 284:1 Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Concentrated Liquid Similac Advance 385-mL cans 12/case Step 2 Powder B Similac Advance 658-g containers 6/case Step Similac Advance 964-g containers 6/case Step 2 Ingredients not genetically engineered. RRR-α-tocopherol provided as d-α-tocopheryl acetate, the most bioactive form of vitamin E. Similar to other infant formulas. REFERENCES: 1. Canadian Food Inspection Agency. Health Claims - Nutrient Function Claims. Last modified on May 11, Accessed in June Zimmer JP et al. Clin Ophtalmol 2007;1: Krinsky NI et al. Ann Rev Nutr 2003;23: Vishwanathan R et al. JPGN 2014;59(5); Johnson EJ. Nutrition Reviews 2014;72(9): Moulton C et al. Natural vitamin E (RRR-alpha-tocopherol) is the predominant vitamin E stereoisomer in human milk. Abstract Stone WL et al. Am J Clin Nutr 2003;77: Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. National Academy of Sciences Kuchan MJ et al. Br J Nutr 2016;116: Williams T et al. JPGN 2014;59(5): Ben XM et al. Chin Med J (Engl) 2004;117: Ben XM et al. World J Gastroenterol 2008; 14(42):

53 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 509 (2130) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.3 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 49.9 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.71:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower or sunflower oil, soy oil, coconut oil, ARA and DHA MCT oil (% of total fats) CARBOHYDRATE (g) % of total energy 41.8 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose, dry skim milk, galactooligosaccharides Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (190) 85 (282) Vitamin D3 (mcg [IU]) 7.63 (305) 1.02 (40.5) 1.50 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 135 (5.87) 18 (0.78) 27 (1.15) Potassium (mg [mmol]) 600 (15.38) 79 (2.06) 118 (3.02) Chloride (mg [mmol]) 333 (9.39) 44 (1.25) 65 (1.83) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) Nutritional information for Similac Advance Step 2, Powder GOS is approximately 1% of the total energy and provides approximately 1.3 Cal/g. INGREDIENTS Similac Advance Step 2, Powder: Lactose, dry skim milk, high oleic safflower or sunflower oil, soy oil, coconut oil, galactooligosaccharides (GOS), whey protein concentrate, tricalcium phosphate, whey protein hydrolysate, potassium citrate, M. alpina oil*, calcium carbonate, potassium hydroxide, C. cohnii oil**, soy lecithin, magnesium chloride, sodium chloride, choline bitartrate, ascorbic acid, L-tryptophan, ferrous sulphate, taurine, m-inositol, cytidine 5'-monophosphate, disodium guanosine 5'-monophosphate, ascorbyl palmitate, disodium uridine 5'-monophosphate, zinc sulphate, d-α-tocopheryl acetate, adenosine 5'-monophosphate, L-carnitine, mixed tocopherols, niacinamide, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, lutein, folic acid, manganese sulphate, β-carotene, phylloquinone, biotin, sodium selenite, potassium iodide, vitamin D3, cyanocobalamin. Similac Advance Step 2, Concentrated Liquid: Water, lactose, dry or evaporated skim milk, high oleic vegetable oil (safflower or sunflower), soy oil, galactooligosaccharides (GOS), coconut oil, whey protein concentrate, calcium phosphate, potassium citrate, calcium carbonate, M. alpina oil*, calcium carbonate, monoglycerides, soy lecithin, C. cohnii oil**, potassium chloride, choline bitartrate, ascorbic acid, L-tryptophan, carrageenan, magnesium chloride, taurine, ferrous sulphate, cytidine 5'-monophosphate, citric acid, disodium guanosine 5'-monophosphate, d-α-tocopheryl acetate, zinc sulphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, niacinamide, L-carnitine, zinc sulphate, calcium d-pantothenate, vitamin A palmitate, thiamine chloride hydrochloride, riboflavin, cupric sulphate, pyridoxine hydrochloride, folic acid, phylloquinone, lutein, β-carotene, biotin, manganese sulphate, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Lactose, other soy components, coconut oil. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ADVANCE STEP 2 NON-GMO DHA- and ARA-enriched formula For infants and toddlers 6 to 24 months of age

54 SIMILAC Step 2 NON-GMO For infants and toddlers 6 to 24 months of age INDICATIONS FOR USE For use in infants 6 months and older as they transition to solid foods. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Specially formulated to help bridge the nutritional gaps that can be associated with the transition to table foods. Calcium enriched (~50% more calcium than Similac Step 1) to support growing bones. Non-GMO. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 8.2 Fat (% of total energy) 48.8 Carbohydrate (% of total energy) 43.0 Total Cal:g nitrogen ratio 304.8:1 Non-protein Cal:g nitrogen ratio 279.8:1 Water (g/l) 901 Osmolality (mosm/kg water) 303 Renal solute load (mosm/l) 97 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder 0S Similac Step g cans 6/case Ingredients not genetically engineered. Similar to other infant formulas. 54

55 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 513 (2146) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.2 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 48.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 11.9:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, soy oil, coconut oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 43.0 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (189) 83 (279) Vitamin D3 (mcg [IU]) 5.9 (236) 0.78 (31) 1.15 (46) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 122 (5.30) 16 (0.70) 24 (1.03) Potassium (mg [mmol]) 567 (14.54) 75 (1.92) 111 (2.83) Chloride (mg [mmol]) 300 (8.46) 40 (1.13) 58 (1.65) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION Nutritional information for Similac Step 2, Powder INGREDIENTS Similac Step 2, Powder: Skim milk, lactose, high oleic sunflower oil, soy oil, coconut oil, whey protein concentrate, potassium citrate, whey protein hydrolysate, tricalcium phosphate, calcium carbonate, soy lecithin, ascorbic acid, choline bitartrate, magnesium chloride, potassium chloride, sodium chloride, ferrous sulphate, taurine, L-tryptophan, m-inositol, m-inositol, cytidine 5'-monophosphate, ascorbyl palmitate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, zinc sulphate, adenosine 5'-monophosphate, d-α-tocopheryl acetate, mixed tocopherols, niacinamide, L-carnitine, d-calcium pantothenate, vitamin A palmitate, copper sulphate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, manganese sulphate, β-carotene, folic acid, potassium iodide, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC Step 2 NON-GMO For infants and toddlers 6 to 24 months of age

56 SIMILAC Step 1 NON-GMO For term infants 0+ months of age INDICATIONS FOR USE For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Non-GMO. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 8.2 Fat (% of total energy) 48.8 Carbohydrate (% of total energy) 43.0 Total Cal:g nitrogen ratio 304.8:1 Non-protein Cal:g nitrogen ratio 279.8:1 Water (g/l) 901 Osmolality (mosm/kg water) 303 Renal solute load (mosm/l) 97 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder 0S Similac Step g cans 6/case Ingredients not genetically engineered. Similar to other infant formulas. 56

57 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 513 (2146) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.2 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 48.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 11.9:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, soy oil, coconut oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 43.0 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (189) 83 (279) Vitamin D3 (mcg [IU]) 5.9 (236) 0.78 (31) 1.15 (46) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 122 (5.30) 16 (0.70) 24 (1.03) Potassium (mg [mmol]) 567 (14.54) 75 (1.93) 111 (2.83) Chloride (mg [mmol]) 300 (8.46) 40 (1.12) 58 (1.65) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) Nutritional information for Similac Step 1, Powder INGREDIENTS Similac Step 1, Powder: Skim milk, lactose, high oleic sunflower oil, soy oil, coconut oil, whey protein concentrate, potassium citrate, whey protein hydrolysate, calcium carbonate, soy lecithin, ascorbic acid, choline bitartrate, magnesium chloride, sodium chloride, potassium chloride, ferrous sulphate, taurine, L-tryptophan, m-inositol, cytidine 5'-monophosphate, ascorbyl palmitate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, zinc sulphate, adenosine 5'-monophosphate, d-α-tocopheryl acetate, mixed tocopherols, niacinamide, L-carnitine, calcium d-pantothenate, vitamin A palmitate, copper sulphate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, manganese sulphate, β-carotene, folic acid, potassium iodide, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC Step 1 NON-GMO For term infants 0+ months of age

58 SIMILAC LOWER IRON Step 1 NON-GMO For term infants 0+ months of age INDICATIONS FOR USE For initial or supplemental feeding of term infants. For infants whose health care professional wishes to provide a lower iron formulation. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Lower iron content (0.65 mg/100 ml) than Similac Step 1 (1.1 mg/100 ml). Non-GMO. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 8.2 Fat (% of total energy) 48.8 Carbohydrate (% of total energy) 43.0 Total Cal:g nitrogen ratio 304.8:1 Non-protein Cal:g nitrogen ratio 279.8:1 Water (g/l) 901 Osmolality (mosm/kg water) 303 Renal solute load (mosm/l) 97 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder 0S Similac Lower Iron 850-g cans 6/case Ingredients not genetically engineered. Similar to other infant formulas. 58

59 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 513 (2146) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.2 Arginine (mg) Cystine (mg) Tyrosin (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 48.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (ADH) (g) Omega-6:Omega-3 ratio 11.9 :1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, soy oil, coconut oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 43.0 Total dietary fibre (g) Fructooligosaccharides (FOS) (g) Galactooligosaccharides (GOS) (g) Lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (189) 84 (279) Vitamin D3 (mcg [IU]) 5.9 (236) 0.78 (31) 1.15 (46) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 122 (5.30) 16 (0.70) 24 (1.03) Potassium (mg [mmol]) 567 (14.54) 75 (2.13) 111 (2.83) Chloride (mg [mmol]) 300 (8.46) 40 (1.13) 58 (1.65) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) Nutritional information for Similac Lower Iron, Powder INGREDIENTS Similac Lower Iron, Powder: Skim milk, lactose, high oleic sunflower oil, soy oil, coconut oil, whey protein concentrate, potassium citrate, whey protein hydrolysate, calcium carbonate, soy lecithin, ascorbic acid, choline bitartrate, magnesium chloride, sodium chloride, potassium chloride, taurine, L-tryptophan, m-inositol, ferrous sulphate, cytidine 5'-monophosphate, ascorbyl palmitate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, zinc sulphate, adenosine 5'-monophosphate, d-α-tocopheryl acetate, mixed tocopherols, niacinamide, L-carnitine, calcium d-pantothenate, vitamin A palmitate, copper sulphate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, manganese sulphate, β-carotene, folic acid, potassium iodide, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC LOWER IRON Step 1 NON-GMO For term infants 0+ months of age

60 SIMILAC TOTAL COMFORT Step 1 NON-GMO For term infants 0+ months of age INDICATIONS FOR USE For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS 100% partially hydrolyzed whey protein. DHA, an omega-3 fatty acid, to support the normal physical development of the brain and eyes. 1 Non-GMO. Tummy-friendly and easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 9.4 Fat (% of total energy) 48.5 Carbohydrate (% of total energy) 42.1 Total Cal:g nitrogen ratio 264:1 Non-protein Cal:g nitrogen ratio 239:1 Water (g/l) 900 Osmolality (mosm/kg water) 180 Renal solute load (mosm/l) 158 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder C Similac Total Comfort TM 638-g containers 6/case Ingredients not genetically engineered. Similar to other infant formulas. REFERENCE: 1. Canadian Food Inspection Agency: Guide to Food Labeling and Advertising, Chapter 8. Available at: 3/ ?chap=8+-+s16c8. Accessed in January

61 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 511 (2138) 67.6 (283) 100 (418) PROTEIN (g) % of total energy 9.4 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Whey protein hydrolysate FAT (g) % of total energy 42.1 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.81:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, coconut oil, soy oil, ARA and DHA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 48.5 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 460 (1532) 61 (203) 90 (300) Vitamin D3 (mcg [IU]) 7.66 (306) 1.01 (40.5) 1.50 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 225 (9.78) 30 (1.30) 44 (1.92) Potassium (mg [mmol]) 671 (17.21) 88.8 (2.29) 131 (3.37) Chloride (mg [mmol]) 408 (11.51) 54 (1.52) 80 (2.24) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS Similac Total ComfortTM, Powder: Corn maltodextrin, whey protein hydrolysate, high oleic safflower oil, sucrose, soy oil, coconut oil, calcium citrate, potassium phosphate, calcium phosphate, M. alpina oil*, potassium hydroxide, sodium chloride, magnesium chloride, ascorbic acid, C. cohnii oil**, potassium chloride, choline chloride, calcium hydroxide, taurine, choline bitartrate, m-inositol, ferrous sulphate, cytidine 5'-monophosphate, zinc sulphate, disodium guanosine 5'-monophosphate, ascorbyl palmitate, d-α-tocopheryl acetate, L-carnitine, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, mixed tocopherols, niacinamide, calcium pantothenate, potassium citrate, cupric sulphate, vitamin A palmitate, riboflavin, thiamine chloride hydrochloride, pyridoxine hydrochloride, manganese sulphate, folic acid, potassium iodide, phylloquinone, sodium selenate, biotin, vitamin D3, cyanocobalamin. Contains: milk, soy. Not for infants or children with galactosemia. * of Arachidonic Acid (ARA). ** of Docosahexaenoic Acid (DHA). CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, lactose, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC TOTAL COMFORT TM Step 1 NON-GMO For term infants 0+ months of age

62 SIMILAC SENSITIVE LACTOSE SENSITIVITY Step 1 NON-GMO For term infants 0+ months of age INDICATIONS FOR USE For infants with symptoms of lactose intolerance such as fussiness, gas and/or diarrhea. 1 For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precautions: Not for parenteral use. Not for infants with galactosemia, congenital lactase deficiency or confirmed cow s milk protein allergy. 2 FEATURES AND BENEFITS Cow s milk based formula. Unique blend of two carbohydrates (corn syrup and sucrose) digested by separate enzyme systems which may help maximize absorption. 3 Clinically shown to support normal infant growth. 1 Non-GMO. Easy to digest. TECHNICAL DATA Concentrated Liquid (at standard dilution) Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio 297:1 293:1 Non-protein Cal:g nitrogen ratio 272:1 268:1 Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Concentrated Liquid Similac Sensitive 385-mL cans 12/case Lactose Sensitivity Powder C Similac Sensitive 638-g containers 6/case Lactose Sensitivity Ingredients not genetically engineered. Formulation used in this study may differ slightly from the Canadian product. Similar to other infant formulas. REFERENCES: 1. Lasekan JB et al. Lactose-free Milk Protein-Based Formula: Impact on Growth and Gastrointestinal Tolerance in Infants. Clin Pediatr 2011;50(4): Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement of Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Available at Accessed in January Kerzner B et al. Jejunal absorption of Sucrose (S) and Glucose Oligomers (GO) in the Absence of Pancreatic Amylase (PA). Pediatr Res 1983;17;191A. 62

63 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 514 (2151) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.7 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Milk protein concentrate, whey protein hydrolysate FAT (g) % of total energy 48.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 9.5:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) 0,0 0,0 0,0 High oleic vegetable oil (safflower or sunflower), coconut oil, soy oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.5 Dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (189) 84 (279) Vitamin D3 (mcg [IU]) 7.63 (305) 1.00 (40) 1.5 (59) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 154 (6.70) 20 (0.87) 30 (1.30) Potassium (mg [mmol]) 620 (15.90) 82 (2.10) 121 (3.09) Chloride (mg [mmol]) 338 (9.53) 45 (1.27) 66 (1.85) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) Nutritional information for Similac Sensitive Lactose Sensitivity, Powder INGREDIENTS Similac Sensitive Lactose Sensitivity, Powder: Corn syrup, sucrose, milk protein concentrate, high oleicvegetable oil (safflower or sunflower), coconut oil, soy oil, potassium citrate, sodium citrate, potassium chloride, calcium phosphate, whey protein hydrolysate, ascorbic acid, magnesium phosphate, choline chloride, magnesium chloride, choline bitartrate, ferrous sulphate, taurine, m-inositol, cytidine 5'-monophosphate, ascorbyl palmitate, disodium guanosine 5'-monophosphate, dl-α-tocopheryl acetate, disodium uridine 5'-monophosphate, L-carnitine, zinc sulphate, adenosine 5'-monophosphate, mixed tocopherols, niacinamide, potassium hydroxide, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, potassium iodide, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenite, vitamin D3, cyanocobalamin. May contain calcium carbonate. Contains milk, soy. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, other soy components, citric acid. Similac Sensitive Lactose Sensitivity, Concentrated Liquid: Water, corn maltodextrin, sucrose, milk protein isolate, high oleic vegetable oil (safflower or sunflower), soy oil, coconut oil, modified corn starch, calcium phosphate, potassium citrate, potassium chloride, M. alpina oil*, magnesium chloride, monoglycerides, soy lecithin, C. cohnii oil**, carrageenan, ascorbic acid, potassium hydroxide, choline chloride, sodium chloride, ferrous sulphate, choline bitartrate, taurine, m-inositol, cytidine 5'-monophosphate, dl-α-tocopheryl acetate, disodium guanosine 5 -monophosphate, disodium uridine 5 -monophosphate, zinc sulphate, adenosine 5'-monophosphate, L-carnitine, calcium carbonate, niacinamide, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine chloride hydrochloride, pyridoxine hydrochloride, riboflavin, potassium iodide, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenite, vitamin D3, cyanocobalamin. Contains: milk, soy. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC SENSITIVE LACTOSE SENSITIVITY Step 1 NON-GMO For term infants 0+ months of age NUTRITIONAL INFORMATION

64 SIMILAC SENSITIVE FOR BABIES SENSITIVE TO LACTOSE Step 1 formula For term infants 0+ months of age INDICATIONS FOR USE For infants with mild symptoms of lactose intolerance such as fussiness, gas and/or diarrhea. 1 For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precautions: Not for parenteral use. Not for infants with galactosemia, congenital lactase deficiency or confirmed cow's milk protein allergy. 2 FEATURES AND BENEFITS Cow's milk protein-based formula. Unique blend of two carbohydrates (corn syrup and sucrose) digested by separate enzyme systems which may help maximize absorption. 3 Clinically shown to support normal infant growth. 1 Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 8.8 Fat (% of total energy) 48.7 Carbohydrate (% of total energy) 42.5 Total Cal:g nitrogen ratio 287:1 Non-protein Cal:g nitrogen ratio 262:1 Water (g/l) 900 Osmolality (mosm/kg water) 218 Renal solute load (mosm/l) 136 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Sensitive 59-mL 48/case for babies sensitive to lactose plastic bottles The formulation used in this study may differ slightly from the Canadian product. Similar to other infant formulas. REFERENCES: 1. Lasekan JB et al. Lactose-free Milk Protein-Based Formula: Impact on Growth and Gastrointestinal Tolerance in Infants. Clin Pediatr 2011; 50(4): Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement of Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Available from Accessed in January Kerzner B et al. Jejunal absorption of Sucrose (S) and Glucose Oligomers (GO) in the Absence of Pancreatic Amylase (PA). Pediatr Res 1983;17;191A. 64

65 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 68 (283) 100 (418) 40 (168) PROTEIN (g) % of total energy 8.8 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Total milk protein FAT (g) % of total energy 48.7 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.4:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) <1 <1.5 <0.6 High oleic safflower oil, coconut oil, soy oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.5 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 60 (200) 88 (294) 35 (118) Vitamin D3 (mcg [IU]) 1.00 (40) 1.47 (59) 0.59 (24) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 20 (0.87) 29 (1.28) 12 (0.51) Potassium (mg [mmol]) 72 (1.85) 106 (2.71) 42 (1.09) Chloride (mg [mmol]) 44 (1.24) 65 (1.83) 26 (0.73) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Sensitive for babies sensitive to lactose, Ready to use: Water, corn maltodextrin, sucrose, milk protein isolate, high oleic safflower oil, coconut oil, soy oil, calcium phosphate tribasic, potassium citrate, carrageenan, ascorbic acid, potassium chloride, monoglycerides, soy lecithin, sodium citrate, calcium phosphate dibasic, magnesium chloride, magnesium phosphate dibasic, choline chloride, choline bitartrate, ferrous sulphate, taurine, m-inositol, cytidine 5'-monophosphate, dl-α-tocopheryl acetate, L-tryptophan, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, zinc sulphate, L-carnitine, niacinamide, d-calcium pantothenate, riboflavin, vitamin A palmitate, thiamine hydrochloride, cupric sulphate, pyridoxine hydrochloride, manganese sulphate, folic acid, phylloquinone, potassium iodide, biotin, sodium selenite, vitamin D3, cyanocobalamin. May contain potassium hydroxide. Contains: milk, soy. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC SENSITIVE FOR BABIES SENSITIVE TO LACTOSE Step 1 formula For term infants 0+ months of age

66 SIMILAC ISOMIL Step 1 with DHA Soy-based Non-GMO formula For infants 0+ months of age INDICATIONS FOR USE For infants with IgE-mediated cow s milk allergy where tolerance to soy has been established. 1,2 For infants whose parents wish to provide a non-milk-based formula for health, cultural, or religious reasons. For infants with lactase deficiency and/or sensitivity to lactose. For infants with galactosemia. For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Growth similar to that of infants fed breast milk or milk-based Similac. 3 Unique blend of carbohydrates digested by separate enzyme systems which may help maximize absorption. 4 DHA, an omega-3 fatty acid that supports the normal physical development of the brain and eyes. 5 Soy protein-based, cow's milk protein-free. Naturally lactose-free. No milk or milk products. Non-GMO. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.66 Protein (% of total energy) 10.0 Fat (% of total energy) 48.0 Carbohydrate (% of total energy) 42.0 Total Cal:g nitrogen ratio 251:1 Non-protein Cal:g nitrogen ratio 226:1 Water (g/l) 901 Osmolality (mosm/kg water) 200 Renal solute load (mosm/l) 162 Viscosity at room temperature/chilled - Minimum tube size for gravity/pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder 0S Similac Isomil 800-g cans 6/case Ingredients not genetically engineered. Comparison based on previous formulations of Similac Step 1 and Similac Isomil. Similar to other infant formulas. REFERENCES: 1. Leung A, Otley A. Canadian Paediatric Society: Nutrition and Gastroenterology Committee. Concerns for the use of soy-based formulas in infant nutrition. Pediatric Child Health 2009;14(3): [Reaffirmed: Jan 30, 2013]. 2. Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement from Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Last modified in August Accessed in December Lasekan JB et al. Growth of Newborn, Term Infants Fed Soy Formulas For 1 Year. Clin Pediatr 1999; Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 5. Canadian Food Inspection Agency: Guide to Food Labeling and Advertising, Chapter 8. Available at: 3/ ?chap=8+-+s16c8. Accessed in January

67 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) (2111.3) 66 (278) 100 (418) PROTEIN (g) % of total energy 10.0 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Soy protein isolate FAT (g) % of total energy 48.0 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.1:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, coconut oil, soy oil, ARA and DHA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.0 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 459 (1530) 60 (201) 90 (303) Vitamin D3 (mcg [IU]) 6.5 (259) 1 (34) 1.28 (51) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 219 (9.91) 29 (1.30) 43 (1.89) Potassium (mg [mmol]) 520 (14.23) 68 (1.87) 103 (2.64) Chloride (mg [mmol]) 404 (9.0) 53 (1.18) 80 (2.25) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS Similac Isomil, Powder: Corn syrup, soy protein isolate, high oleic sunflower oil, sucrose, coconut oil, soy oil, calcium phosphate, potassium citrate, soy lecithin, sodium chloride, potassium chloride, magnesium chloride, *M. alpina oil, **C. cohnii oil, L-methionine, m-inositol, ascorbic acid, choline chloride, taurine, ascorbyl palmitate, L-tryptophan, zinc sulphate, ferrous sulphate, L-carnitine, mixed tocopherols, niacinamide, calcium d-pantothenate, d-α-tocopheryl acetate, vitamin A palmitate, riboflavin, thiamine hydrochloride, cupric sulphate, pyridoxine hydrochloride, potassium iodide, folic acid, phylloquinone, sodium selenite, biotin, vitamin D3, cyanocobalamin. May contain calcium carbonate, potassium phosphate, sodium citrate, manganese sulphate. Contains: Soy. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, other soy components. Contains no dairy ingredients. Manufactured on dairy equipment. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ISOMIL Step 1 with DHA Soy-based Non-GMO formula For infants 0+ months of age

68 SIMILAC ISOMIL OMEGA-3 AND OMEGA-6 Step 1 Soy-based, DHA- and ARA-enriched formula For infants 0+ months of age INDICATIONS FOR USE For infants with IgE-mediated cow s milk allergy where tolerance to soy has been established. 1,2 For infants whose parents wish to provide a non-milk-based formula for health, cultural or religious reasons. For infants with lactase deficiency and/or sensitivity to lactose. For infants with galactosemia. For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precautions: Not for parenteral use. For infants with galactosemia, Similac Isomil powder is the preferred format. FEATURES AND BENEFITS Growth similar to that of infants fed breast milk or milk-based Similac. 3 Unique blend of carbohydrates digested by separate enzyme systems which may help maximize absorption. 4 DHA, an omega-3 fatty acid that supports the normal physical development of the brain and eyes. 5 Soy protein-based, cow milk protein-free. Naturally lactose free. No milk or milk products. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 9.8 Fat (% of total energy) 49.0 Carbohydrate (% of total energy) 41.2 Total Cal:g nitrogen ratio 256:1 Non-protein Cal:g nitrogen ratio 230:1 Water (g/l) 903 Osmolality (mosm/kg water) 219 Renal solute load (mosm/l) 151 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Isomil 59-mL 48/case Omega-3 and Omega-6 plastic bottles Comparison based on previous formulations of Similac Step 1 and Similac Isomil. Similar to other infant formulas. REFERENCES: 1. Leung A, Otley A. Canadian Paediatric Society: Nutrition and Gastroenterology Committee. Concerns for the use of soy-based formulas in infant nutrition. Pædiatr Child Health 2009;14(3): [Reaffirmed: Jan 30, 2013]. 2. Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement from Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Last modified in August Available at nutrition/infant-nourisson/recom/index-eng.php. Accessed in December Lasekan JB et al. Growth of Newborn, Term Infants Fed Soy Formulas For 1 Year. Clin Pediatr 1999; Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 5. Canadian Food Inspection Agency: Guide to food labeling and advertising health claims (chap. 8). Available at: health-claims/eng/ / ?chap=8+-+s16c8. Accessed in January

69 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 68 (283) 100 (418) 40 (168) PROTEIN (g) % of total energy 9.8 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Soy protein isolate FAT (g) % of total energy 49.1 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 8.9:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, soy oil, coconut oil, DHA and ARA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 41.2 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 57 (189) 83 (278) 34 (112) Vitamin D3 (mcg [IU]) 0.90 (36) 1.32 (53) 0.53 (21) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 27 (1.17) 40 (1.73) 16 (0.69) Potassium (mg [mmol]) 92 (2.36) 135 (3.47) 54 (1.39) Chloride (mg [mmol]) 40 (1.13) 59 (1.66) 24 (0.67) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Isomil Omega-3 and Omega-6, Ready to use: Water, corn syrup, soy protein isolate, high oleic safflower oil, sucrose, soy oil, coconut oil, calcium citrate, calcium phosphate, ascorbic acid, potassium phosphate dibasic, potassium phosphate monobasic, magnesium chloride, monoglyceride, soy lecithin, *M. alpina oil, potassium chloride, L-methionine, potassium citrate, choline bitartrate, **C. cohnii oil, carrageenan, sodium citrate, sodium chloride, L-tryptophan, taurine, ferrous sulphate, inositol, zinc sulphate, d-α-tocopheryl acetate, L-carnitine tartrate, calcium d-pantothenate, niacinamide, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, manganese sulphate, potassium iodide, folic acid, phylloquinone, sodium selenate, biotin, vitamin D3, cyanocobalamin. May contain potassium hydroxide, citric acid. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Soy. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, other soy components. Contains no dairy ingredients. Manufactured on dairy equipment. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ISOMIL OMEGA-3 AND OMEGA-6 Step 1 Soy-based, DHA- and ARA-enriched formula For infants 0+ months of age

70 SIMILAC ISOMIL Step 1 NON-GMO Soy-based formula For infants 0+ months of age INDICATIONS FOR USE For infants with IgE-mediated cow s milk allergy where tolerance to soy has been established. 1,2 For infants whose parents wish to provide a non-milk-based formula for health, cultural, or religious reasons. For infants with lactase deficiency and/or sensitivity to lactose. For infants with galactosemia. For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Growth similar to that of infants fed breast milk or milk-based Similac. 3 Unique blend of carbohydrates digested by separate enzyme systems which may help maximize absorption. 4 Soy protein-based, cow's milk protein-free. Naturally lactose-free. No milk or milk products. Non-GMO. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 9.7 Fat (% of total energy) 48.8 Carbohydrate (% of total energy) 41.5 Total Cal:g nitrogen ratio 258:1 Non-protein Cal:g nitrogen ratio 233:1 Water (g/l) 901 Osmolality (mosm/kg water) 218 Renal solute load (mosm/l) 154 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder 0L Similac Isomil Step g cans 6/case Ingredients not genetically engineered. Comparison based on previous formulation of Similac Step 1. Similar to other infant formulas. REFERENCES: 1. Leung A, Otley A. Canadian Paediatric Society: Nutrition and Gastroenterology Committee. Concerns for the use of soy-based formulas in infant nutrition. Paediatr Child Health 2009;14(3): [Reaffirmed: Jan 30, 2013]. 2. Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement from Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Last modified in August Available at fn-an/nutrition/infant-nourisson/recom/index-eng.php. Accessed in December Lasekan JB et al. Growth of Newborn, Term Infants Fed Soy Formulas For 1 Year. Clin Pediatr 1999; Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 70

71 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 516 (2158) 68 (284) 100 (418) PROTEIN (g) % of total energy 9.7 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Soy protein isolate FAT (g) % of total energy 48.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 11.0:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil or high oleic safflower oil, coconut oil, soy oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 41.5 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 456 (1521) 60 (200) 88 (294) Vitamin D3 (mcg [IU]) 7.6 (304) 1 (40) 1.47 (59) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 228 (9.91) 30 (1.30) 44 (1.92) Potassium (mg [mmol]) 555 (14.23) 73 (1.87) 107 (2.75) Chloride (mg [mmol]) 319 (9.0) 42 (1.18) 62 (1.74) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS Similac Isomil Step 1, Powder: Corn syrup, sucrose, soy protein isolate, high oleic sunflower oil, coconut oil, soy oil, calcium phosphate tribasic, potassium citrate, sodium chloride, magnesium chloride, L-methionine, choline bitartrate, ascorbic acid, taurine, potassium chloride, ascorbyl palmitate, ferrous sulphate, dl-α-tocopheryl acetate, L-carnitine tartrate, zinc sulphate, niacinamide, mixed tocopherols, calcium d-pantothenate, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, β-carotene, manganese sulphate, folic acid, potassium iodide, phylloquinone, biotin, sodium selenite, vitamin D3, cyanocobalamin. May contain L-carnitine, calcium carbonate, potassium phosphate dibasic, sodium citrate, choline chloride. Contains: soy. CONTAINS: Priority food allergens: Soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, other soy components. Contains no dairy ingredients. Manufactured on dairy equipment. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ISOMIL Step 1 NON-GMO Soy-based formula For infants 0+ months of age

72 SIMILAC 24 OMEGA-3 AND OMEGA-6 Hypercaloric, DHA- and ARA- enriched formula For term infants 0+ months of age INDICATIONS FOR USE For infants with increased caloric needs. For volume restricted infants. For oral or tube feeding use. Safety precautions: Use under medical supervision. Not for parenteral use. FEATURES AND BENEFITS Increased caloric density: provides 81 Cal per 100 ml (24 Cal/30 ml). DHA, an omega-3 fatty acid that supports the normal physical development of the brain and eyes. 1 Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.81 Protein (% of total energy) 8.3 Fat (% of total energy) 49.4 Carbohydrate (% of total energy) 42.3 Total Cal:g nitrogen ratio 301:1 Non-protein Cal:g nitrogen ratio 275:1 Water (g/l) 884 Osmolality (mosm/kg water) 375 Renal solute load (mosm/l) 156 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac mL 48/case Omega-3 and Omega-6 plastic bottles Similar to other infant formulas. REFERENCE: 1. Canadian Food Inspection Agency: GUIDE TO FOOD LABELLING AND ADVERTISING Health Claims. Chapter 8. Retrieved from: Accessed in January

73 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 81 (340) 100 (420) 48 (200) PROTEIN (g) % of total energy 8.3 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Valine (mg) Taurine (mg) Carnitine (mg) Dry or condensed skim milk, whey protein concentrate FAT (g) % of total energy 49.4 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 8.8:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, coconut oil, soy oil, ARA and DHA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.3 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 72 (240) 89 (296) 42 (142) Vitamin D3 (mcg [IU]) 1.05 (42) 1.30 (52) 0.62 (25) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 22 (0.96) 27 (1.18) 13 (0.56) Potassium (mg [mmol]) 95 (2.44) 117 (3.01) 56 (1.44) Chloride (mg [mmol]) 53 (1.50) 65 (1.85) 31 (0.88) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac 24 Omega-3 and Omega-6, Ready to use: Water, lactose, dry or condensed skim milk, high oleic safflower oil, coconut oil, soy oil, whey protein concentrate, ascorbic acid, M. alpina oil*, calcium carbonate, potassium citrate, C. cohnii oil**, monoglycerides, soy lecithin, sodium citrate, potassium chloride, magnesium chloride, calcium phosphate, carrageenan, potassium phosphate, choline chloride, ferrous sulphate, taurine, m-inositol, citric acid, L-tryptophan, d-α-tocopheryl acetate, zinc sulphate, niacinamide, calcium d-pantothenate, L-carnitine, cupric sulphate, vitamin A palmitate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, phylloquinone, manganese sulphate, biotin, vitamin D3, cyano cobalamin. May contain sodium selenate, magnesium sulphate, sodium chloride, potassium iodide, potassium hydroxide. * of Arachidonic Acid (ARA). ** of Docosahexaenoic Acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, citric acid, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC 24 OMEGA-3 AND OMEGA-6 Hypercaloric, DHA- and ARA- enriched formula For term infants 0+ months of age

74 SIMILAC ALIMENTUM Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age INDICATIONS FOR USE A nutritionally complete, hypoallergenic formula for infants with: - Colic symptoms due to protein sensitivity (cow s milk and/or soy protein). - Sensitivity to intact protein (cow s milk and/or soy protein). - Severe food allergies. - Protein maldigestion. - Fat malabsorption. For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precautions: Not for parenteral use. FEATURES AND BENEFITS Similac Alimentum fulfills the accepted international medical standard for a hypoallergenic product. 1,2 Hypoallergenic does not mean non-allergenic. Extensively hydrolyzed casein, supplemented with free amino acids for infants who are sensitive to or unable to digest intact protein. Unique blend of carbohydrates digested by separate enzyme systems which may help maximize absorption. 3 DHA, an omega-3 fatty acid that supports the normal physical development of the brain and eyes. 4 Approximately 33% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 5 Lactose-free carbohydrate. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 11.0 Fat (% of total energy) 48.6 Carbohydrate (% of total energy) 40.4 Total Cal:g nitrogen ratio 230:1 Non-protein Cal:g nitrogen ratio 205:1 Water (g/l) 892 Osmolality (mosm/kg water) 274 Renal solute load (mosm/l) 171 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal No No AVAILABILITY Powder Similac Alimentum 400-g cans 6/case Extensively broken down to small peptides and amino acid components to minimize the potential for allergic reaction. Similar to other infant formulas. REFERENCES: 1. Kleinman RE et al. Use of infant formulas in infants with cow milk allergy: a review and recommendations. Pediatr Allergy Immunol 1991;2: American Academy of Pediatrics. Committee on Nutrition. Hypoallergenic Infant Formulas. Pediatrics 2000;106(2): Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 4. Canadian Food Inspection Agency: Guide to food labeling and advertising health claims (chap. 8). Available at: Accessed in January Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

75 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 517 (2163) 67.6 (283) 100 (418) PROTEIN (g) % of total energy 11 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Casein hydrolysate, free amino acids FAT (g) % of total energy 48.6 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.44:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, MCT oil, soy oil, ARA and DHA MCT oil (% of total fats) 33 CARBOHYDRATE (g) % of total energy 40.4 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, sucrose, modified corn starch Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 465 (1550) 60.8 (203) 90.0 (300) Vitamin D3 (mcg [IU]) 7.75 (310) 1.01 (41.0) 1.50 (60.0) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 227 (9.87) 30.0 (1.30) 43.9 (1.91) Potassium (mg [mmol]) 610 (15.64) 80.0 (2.06) 118 (3.03) Chloride (mg [mmol]) 413 (11.65) 54.0 (1.53) 80 (2.25) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Alimentum, Powder: Corn maltodextrin, casein hydrolysate (derived from milk), high oleic safflower oil, medium chain triglycerides (modified coconut and/or palm kernel oils), sucrose, soy oil, modified corn starch, calcium citrate, calcium phosphate, potassium citrate, xanthan gum, potassium phosphate, *M. alpina oil, L-tyrosine, magnesium chloride, L-cystine hydrochloride, sodium chloride, ascorbic acid, **C. cohnii oil, L-tryptophan, choline chloride, ferrous sulphate, potassium chloride, taurine, m-inositol, dl-α-tocopheryl acetate, ascorbyl palmitate, zinc sulphate, L-carnitine, mixed tocopherols, niacinamide, calcium pantothenate, cupric sulphate, vitamin A palmitate, riboflavin, thiamine chloride hydrochloride, pyridoxine hydrochloride, folic acid, potassium iodide, phylloquinone, biotin, sodium selenite, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, other soy components. Similac Alimentum contains a pre-digested protein (casein hydrolysate). This hypoallergenic formula is specifically designed for infants and children who cannot tolerate milk- or soy-based formulas. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ALIMENTUM Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age

76 SIMILAC ALIMENTUM Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age INDICATIONS FOR USE A nutritionally complete, hypoallergenic formula for infants with: - Colic symptoms due to protein sensitivity (cow s milk and/or soy protein). - Sensitivity to intact protein (cow s milk and/or soy protein). - Severe food allergies. - Protein maldigestion. - Fat malabsorption. For initial or supplemental feeding. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Similac Alimentum fulfills the accepted international medical standard for a hypoallergenic product. 1,2 Hypoallergenic does not mean non-allergenic. Extensively hydrolyzed casein, supplemented with free amino acids for infants who are sensitive to or unable to digest intact protein. Unique blend of carbohydrates digested by separate enzyme systems which may help maximize absorption. 3 Approximately 33% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 4 Lactose-free carbohydrate. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 11 Fat (% of total energy) 49 Carbohydrate (% of total energy) 40 Total Cal:g nitrogen ratio Non-protein Cal:g nitrogen ratio Water (g/l) 900 Osmolality (mosm/kg water) 370 Renal solute load (mosm/l) 123 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal No No AVAILABILITY Ready to use Similac Alimentum 237-mL cans 6 x 4/case Extensively broken down to small peptides and amino acid components to minimize the potential for allergic reaction. Similar to other infant formulas. REFERENCES: 1. Kleinman RE et al. Use of infant formulas in infants with cow milk allergy: a review and recommendations. Pediatr Allergy Immunol 1991;2: American Academy of Pediatrics. Committee on Nutrition. Hypoallergenic Infant Formulas. Pediatrics 2000;106(2): Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 4. Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

77 ENERGY Per 100 ml Per 100 Cal Per 237 ml ENERGY (Cal [kj]) 68 (285) 100 (418) 161 (674) PROTEIN (g) % of total energy 11 Arginine (mg) Cystine (mg) Tyrosine Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Casein hydrolysate, free amino acids FAT (g) % of total energy 49 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Safflower oil, MCT oil, soy oil MCT oil (% of total fats) 33 CARBOHYDRATE (g) % of total energy 40 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Sucrose, modified tapioca starch Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 61 (203) 90 (300) 144 (481) Vitamin D3 (mcg [IU]) 0.75 (30) 1.13 (45) 1.78 (71) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 30 (1.30) 44 (1.91) 71 (3.09) Potassium (mg [mmol]) 80 (2.05) 118 (3.03) 190 (4.86) Chloride (mg [mmol]) 54 (1.52) 80 (2.26) 128 (3.61) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Alimentum, Ready to use: Water, sucrose, casein hydrolysate (derived from milk), modified tapioca starch, safflower oil, medium chain triglycerides (modified coconut and/or palm kernel oils), soy oil, calcium citrate, calcium phosphate, carrageenan, potassium phosphate, ascorbic acid, magnesium chloride, calcium hydroxide, sodium chloride, potassium chloride, L-cystine dihydrochloride, potassium citrate, L-tyrosine, choline chloride, L-tryptophan, ferrous sulphate, taurine, m-inositol, dl-α-tocopheryl acetate, zinc sulphate, L-carnitine, niacinamide, calcium pantothenate, vitamin A palmitate, cupric sulphate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, potassium iodide, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, other soy components. Similac Alimentum contains a pre-digested protein (casein hydrolysate). This hypoallergenic formula is specifically designed for infants and children who cannot tolerate milk- or soy-based formulas. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ALIMENTUM Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age

78 SIMILAC ALIMENTUM OMEGA-3 AND OMEGA-6 Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age INDICATIONS FOR USE A nutritionally complete, hypoallergenic formula for infants with: - Colic symptoms due to protein sensitivity (cow s milk and/or soy protein) - Sensitivity to intact protein (cow s milk and/or soy protein) - Severe food allergies - Protein maldigestion - Fat malabsorption For initial or supplemental feeding. For oral or tube feeding use. Safety precautions: Not for parenteral use. FEATURES AND BENEFITS Similac Alimentum fulfills the accepted international medical standard for a hypoallergenic product. 1,2 Hypoallergenic does not mean non-allergenic. Extensively hydrolyzed casein, supplemented with free amino acids for infants who are sensitive to or unable to digest intact protein. Unique blend of carbohydrates digested by separate enzyme systems which may help maximize absorption. 3 DHA, an omega-3 fatty acid that supports the normal physical development of the brain and eyes. 4 Approximately 33% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 5 Lactose-free carbohydrate. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 11 Fat (% of total energy) 48 Carbohydrate (% of total energy) 41 Total Cal:g nitrogen ratio Non-protein Cal:g nitrogen ratio Water (g/l) 899 Osmolality (mosm/kg water) 370 Renal solute load (mosm/l) 171 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ 5/5 pump feeding (Fr) Low residue Gluten-free Kosher Halal No No AVAILABILITY Ready to use Similac Alimentum 59-mL plastic 48/case Omega-3 and Omega-6 bottles Extensively broken down to small peptides and amino acid components to minimize the potential for allergic reaction. Similar to other infant formulas. REFERENCES: 1. Kleinman RE et al. Use of infant formulas in infants with cow milk allergy: a review and recommendations. Pediatr Allergy Immunol 1991;2: American Academy of Pediatrics. Committee on Nutrition. Hypoallergenic Infant Formulas. Pediatrics 2000;106(2): Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 4. Canadian Food Inspection Agency: Guide to food labeling and advertising health claims (chap. 8). Available at: Accessed in January Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

79 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 68 (283) 100 (418) 40 (168) PROTEIN (g) % of total energy 11 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Casein hydrolysate, free amino acids FAT (g) % of total energy 48 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Safflower oil, MCT oil, soy oil MCT oil (% of total fats) 33 CARBOHYDRATE (g) % of total energy 41 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Sucrose, modified tapioca starch Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 61 (203) 90 (300) 36 (120) Vitamin D3 (mcg [IU]) 0.75 (30) 1.10 (45) 0.44 (18) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 30 (1.30) 44 (1.92) 18 (0.77) Potassium (mg [mmol]) 80 (2.05) 118 (3.02) 47 (1.21) Chloride (mg [mmol]) 54 (1.52) 80 (2.24) 32 (0.90) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Alimentum Omega-3 and Omega-6, Ready to use: Water, sucrose, casein hydrolysate (derived from milk), modified tapioca starch, safflower oil, medium chain triglycerides (modified coconut and/or palm kernel oils), soy oil, calcium phosphate, calcium citrate, carrageenan, potassium phosphate, ascorbic acid, magnesium chloride, *M. alpina oil, sodium chloride, calcium hydroxide, L-cystine dihydrochloride, potassium chloride, potassium citrate, **C. cohniii oil, L-tyrosine, L-tryptophan, choline chloride, ferrous sulphate, taurine, m-inositol, dl-α-tocopheryl acetate, zinc sulphate, L-carnitine, niacinamide, calcium pantothenate, vitamin A palmitate, cupric sulphate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, potassium iodide, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. May contain potassium hydroxide, citric acid. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, other soy components. Similac Alimentum contains a pre-digested protein (casein hydrolysate). This hypoallergenic formula is specifically designed for infants and children who cannot tolerate milk- or soy-based formulas. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ALIMENTUM OMEGA-3 AND OMEGA-6 Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age

80 NOTES:

81 TODDLERS AND CHILDREN IN THIS SECTION Go & Grow by Similac Step 3 Go & Grow by Similac Step 3 (RTU) PediaSure Complete Grow & Gain PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Peptide 1 Cal Toddlers and Children

82 Toddlers and Children TODDLERS AND CHILDREN

83 LEARN ABOUT scfos WHAT ARE scfos? Short-chain fructooligosaccharides (scfos) are nondigestible carbohydrates that are naturally found in common foods such as bananas, asparagus and onions. 1,2 scfos are recognized as a source of dietary fibre by Health Canada 3 and are defined as prebiotics by the scientific community because they stimulate the growth of beneficial intestinal bacteria. 1 scfos AND THE GASTROINTESTINAL TRACT scfos are not digested in the small intestine, remaining intact until they reach the colon, where they are fermented by beneficial bacteria (such as bifidobacteria and lactobacilli) to short-chain fatty acids (SCFAs). 1,2,4 WHAT BENEFITS DO scfos PROVIDE? scfos can help your patients meet their daily fibre requirements. 3 SCFAs are the preferred energy source for cells in the colon. 4 Abbott Nutrition pediatric products containing scfos: PediaSure Plus (with fibre) PediaSure Peptide 1 Cal PediaSure Complete Grow & Gain Abbott Nutrition adult products containing scfos: Ensure Enlive Ensure scfos Fibre Ensure Pudding Glucerna Bar Glucerna Nutritional Drink Jevity 1.2 Cal Jevity 1.5 Cal Nepro Suplena TwoCal HN REFERENCES: 1. Gibson GR et al. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 1995;108: Handbook of Prebiotics and Probiotics Ingredients: Health Benefits and Food Applications. Cho SS, Finocchiaro ET, eds. CRC Press, Taylor and Francis Group, Health Canada. List of Dietary Fibres Permitted for Use in Foods Available for Sale in Canada, September Topping DL, Clifton PM. Physiological Reviews 2001;81(3)

84 GO & GROW BY SIMILAC Step 3 Toddler Drink / Nutritional Supplement For toddlers 12 to 36 months of age INDICATIONS FOR USE Go & Grow by Similac TM Step 3 toddler drink is designed to help support growth and development and complement the toddler s diet. 1 Safety precautions: Not intended for infants under 12 months of age. For oral feeding only not for tube feeding. Not for parenteral use. Not for children with galactosemia. FEATURES AND BENEFITS Contains an exclusive blend of DHA, lutein, and vitamin E. Provides key nutrients such as protein, iron, and calcium. Contains 0.6 g of galactooligosaccharides (GOS) per serving. Non-GMO. 2 delicious flavours: Milk and Vanilla. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.77 Protein (% of total energy) 16 Fat (% of total energy) 44 Carbohydrate (% of total energy) 40 Total Cal:g nitrogen ratio 159:1 Non-protein Cal:g nitrogen ratio 134:1 Water (g/l) 900 Osmolality (mosm/kg water) 303 Renal solute load (mosm/l) 279 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder 0S Go & Grow by Similac TM 31.2-g sachets 60/case Step 3, Milk flavour 0S Go & Grow by Similac TM 850-g cans 6/case Step 3, Milk flavour 0S Go & Grow by Similac TM 850-g cans 6/case Step 3, Vanilla Ingredients not genetically engineered. REFERENCE: 1. Suthutvoravut U, Abiodun PO, Chomtho S et al. Composition of follow-up formula for young children aged months: recommendations of an international expert group coordinated by the Nutrition Association of Thailand and the Early Nutrition Academy. Annals of Nutrition and Metabolism 2015; 67(2):

85 ENERGY Per 100 ml Powder Per 200 ml (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 484 (2024) 151 (631) 100 (418) PROTEIN (g) % of total energy 16 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk FAT (g) % of total energy 44 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega 6:Omega 3 ratio 8.3:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, soy oil, coconut oil, DHA and ARA MCT oil (% of total fats) 0 CARBOHYDRATE (g) % of total energy 40 Total dietary fibre (g) Galactooligosaccharides (GOS) (g) Skim milk, sucrose, lactose, galactooligosaccharides Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 555 (1850) 173 (577) 113 (376) Vitamin D3 (mcg [IU]) 4 (160) 1.2 (50) 0.8 (33) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 260 (11.3) 81 (3.5) 52.8 (2.3) Potassium (mg [mmol]) 1000 (25.6) 312 (8.0) 203 (5.2) Chloride (mg [mmol]) 775 (21.9) 242 (6.8) 158 (4.4) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodide (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION Nutritional information for Go & Grow by SimilacTM Step 3, Milk flavour, 850-g can INGREDIENTS Go & Grow by Similac TM Step 3, Milk flavour: Skim milk, sucrose, high oleic sunflower oil, lactose, soy oil, coconut oil, galactooligosaccharides, soy lecithin, C. cohnii oil*, choline chloride, choline bitartrate, M. alpina oil**, ascorbyl palmitate, mixed tocopherols, cytidine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, disodium guanosine 5'-mono-phosphate, MINERALS (magnesium chloride, potassium citrate, calcium carbonate, potassium hydroxide, sodium chloride, ferrous sulphate, zinc sulphate, manganese sulphate, copper sulphate), VITAMINS (ascorbic acid, niacinamide, calcium d-pantothenate, vitamin A palmitate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, folic acid, biotin, β-carotene, vitamin D3). May contain calcium chloride, calcium phosphate tribasic. Contains: milk, soy. * of docosahexaenoic acid (DHA). ** of arachidonic acid (ARA). CONTAINS: priority food allergens: Milk, soy. Ingredients associated with food intolerances and/ or sensitivities: Coconut oil, citric acid, lactose, other soy components. Additional ingredient for Vanilla: Artificial vanilla flavour. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. GO & GROW BY SIMILAC TM Step 3 Toddler Drink / Nutritional Supplement For toddlers 12 to 36 months of age

86 GO & GROW BY SIMILAC Step 3 Toddler Drink / Nutritional Supplement For toddlers 12 to 36 months of age INDICATIONS FOR USE Go & Grow by Similac TM Step 3 toddler drink is designed to help support growth and development and complement the toddler s diet. 1 Safety precautions: Not intended for infants under 12 months of age. For oral feeding only not for tube feeding. Not for parenteral use. Not for children with galactosemia. FEATURES AND BENEFITS Provides key nutrients such as protein, iron, calcium, DHA, and vitamin E. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.0 Protein (% of total energy) 16 Fat (% of total energy) 30 Carbohydrate (% of total energy) 54 Total Cal:g nitrogen ratio 160:1 Non-protein Cal:g nitrogen ratio 136:1 Water (g/l) 830 Osmolality (mosm/kg water) 600 Renal solute load (mosm/l) 350 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Go & Grow by Similac 235-mL bottles 4 x 6/case Step 3, Vanilla REFERENCE: 1. Suthutvoravut U, Abiodun PO, Chomtho S et al. Composition of follow-up formula for young children aged months: recommendations of an international expert group coordinated by the Nutrition Association of Thailand and the Early Nutrition Academy. Annals of Nutrition and Metabolism 2015;67(2):

87 ENERGY Per 100 ml Per 235 ml ENERGY (Cal [kj]) 100 (419) 235 (984) PROTEIN (g) % of total energy 16 Arginine (mg) Cystine (mg) Tyrosine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) - - Carnitine (mg) - - Nucleotides (mg) - - Milk protein concentrate, soy protein isolate, whey protein concentrate FAT (g) % of total energy 30 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega 6:Omega 3 ratio 6.2:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Soy oil, canola oil, MCT oil MCT oil (% of total fats) 5 CARBOHYDRATE (g) % of total energy 54 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) - - Sucrose, corn maltodextrin, scfos, cellulose gel Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 100 (333) 235 (783) Vitamin D3 (mcg [IU]) (10.2) (24.0) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) - - Lutein (mg) - - MINERALS Sodium (mg [mmol]) 38 (1.65) 90 (3.91) Potassium (mg [mmol]) 191 (4.90) 450 (11.54) Chloride (mg [mmol]) 87 (2.45) 204 (5.75) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodide (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS Go & Grow by Similac TM Step 3, Vanilla: Water, sucrose, corn maltodextrin, milk protein concentrate, soy oil, soy protein isolate, whey protein concentrate, short-chain fructooligosaccharides (scfos), canola oil, natural and artificial flavours, cellulose gel, medium chain triglycerides, cellulose gum, carrageenan, soy lecithin, monoglycerides, C. cohnii oil*, M. alpina oil**, MINERALS (potassium citrate, magnesium phosphate, calcium phosphate, potassium chloride, potassium phosphate, sodium chloride, potassium hydroxide, zinc sulphate, ferrous sulphate, manganese sulphate, cupric sulphate, potassium iodide, sodium molybdate, chromium chloride, sodium selenate), VITAMINS (choline chloride, ascorbic acid, niacinamide, dl-α-tocopheryl acetate, calcium pantothenate, vitamin A palmitate, pyridoxine hydrochloride, thiamine chloride hydrochloride, riboflavin, folic acid, biotin, vitamin D3, cyanocobalamin). Contains: milk, soy. * of Docosahexaenoic Acid (DHA). ** of Arachidonic Acid (ARA). CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, natural and artificial flavour, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. GO & GROW BY SIMILAC TM Step 3 Toddler Drink / Nutritional Supplement For toddlers 12 to 36 months of age

88 PEDIASURE COMPLETE GROW & GAIN Nutritional supplement For children 1 to 13 years of age INDICATIONS FOR USE Complete, balanced nutrition to help support growth and development. PediaSure Complete Grow & Gain can be used with or between meals as part of a healthy diet. For children: Who are picky eaters. With feeding difficulties. Who require additional nutrients due to poor appetite or intake. With appetite suppression due to medication or treatment. Safety precautions: For oral feeding only not for tube feeding. Not for parenteral use. Not for children with galactosemia. For children under 1 year of age, consult a physician or qualified health care professional prior to using PediaSure Complete Grow & Gain. FEATURES AND BENEFITS Each bottle contains: 26 vitamins and minerals. 9.3 g protein to help build strong muscles and antibodies. DHA (4.3 mg/100 Cal), an omega-3 fatty acid that supports the normal physical development of the brain and eyes. 1 g of short-chain fructooligosaccharides (scfos). 5% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 1 Convenient, reclosable bottle. 3 delicious, kid-approved flavours. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.0 Protein (% of total energy) 16 Fat (% of total energy) 30 Carbohydrate (% of total energy) 54 Total Cal:g nitrogen ratio 160:1 Non-protein Cal:g nitrogen ratio 136:1 Water (g/l) 830 Osmolality (mosm/kg water) 600 Renal solute load (mosm/l) 350 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use PediaSure Complete 235-mL bottles 4 x 4/case Grow & Gain, Vanilla PediaSure Complete 235-mL bottles 4 x 4/case Grow & Gain, Chocolate PediaSure Complete 235-mL bottles 4 x 4/case Grow & Gain, Strawberry REFERENCE: 1. Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

89 ENERGY Per 100 ml Per 235 ml ENERGY (Cal [kj]) 100 (419) 235 (984) PROTEIN (g) % of total energy 16 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) - - Carnitine (mg) - - Milk protein concentrate, soy protein isolate, whey protein concentrate FAT (g) % of total energy 30 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (mg) Linolenic acid (g) Docosahexaenoic acid (DHA) (mg) Omega-6:Omega-3 ratio 6.2:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Soy oil, canola oil, MCT oil MCT oil (% of total fats) 5 CARBOHYDRATE (g) % of total energy 54 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) - - Sucrose, corn maltodextrin, scfos, cellulose gel Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 100 (333) 235 (783) Vitamin D3 (mcg [IU]) 0.3 (10.2) 0.6 (24) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) - - MINERALS Sodium (mg [mmol]) 38 (1.65) 90 (3.91) Potassium (mg [mmol]) 191 (4.90) 450 (11.54) Chloride (mg [mmol]) 87 (2.45) 204 (5.75) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodide (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION Nutritional information for PediaSure Complete Grow & Gain, Vanilla, 235-mL bottle INGREDIENTS PediaSure Complete Grow & Gain, Vanilla: Water, sucrose, corn maltodextrin, milk protein concentrate, soy oil, soy protein isolate, whey protein concentrate, short-chain fructooligosaccharides (scfos), canola oil, natural and artificial flavours, cellulose gel, medium chain triglycerides, cellulose gum, carrageenan, soy lecithin, monoglycerides, *C. cohnii oil, **M. alpina oil, MINERALS (potassium citrate, magnesium phosphate, calcium phosphate, potassium chloride, potassium phosphate, sodium chloride, potassium hydroxide, zinc sulphate, ferrous sulphate, manganese sulphate, cupric sulphate, potassium iodide, sodium molybdate, chromium chloride, sodium selenate), VITAMINS (choline chloride, ascorbic acid, niacinamide, dl-α-tocopheryl acetate, calcium pantothenate, vitamin A palmitate, pyridoxine hydrochloride, thiamine chloride hydrochloride, riboflavin, folic acid, biotin, vitamin D3, cyanocobalamin). Contains: milk, soy. * of docosahexaenoic acid (DHA). ** of arachidonic acid (ARA). CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, natural and artificial flavour, lactose, other soy components. Additional ingredient for chocolate: Dutch process cocoa. Additional ingredient for strawberry: Colour. Ingredients associated with food intolerances and/ or sensitivities: Colour. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIASURE COMPLETE GROW & GAIN TM Nutritional Supplement For children 1 to 13 years of age

90 PEDIASURE Sole-source nutrition For children 1 to 13 years of age INDICATIONS FOR USE For children: - Requiring short- or long-term tube feeding. - With increased nutrient needs. - With or at risk for malnutrition. - With failure to thrive. For oral or tube feeding use. Can be used as a supplement or as a sole source of nutrition. Safety precautions: Not for parenteral use. Not for children with galactosemia. For children under 1 year of age, consult a physician or qualified health care professional prior to using PediaSure. FEATURES AND BENEFITS Fortified with taurine and carnitine to help prevent deficiencies associated with long-term tube feeding % of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source :1 Ca:P ratio to help optimize calcium and phosphorus balance. 5 Isotonic to help with intolerance to hyperosmolar feedings. 5 Provides 27 vitamins and minerals. 3 delicious flavours to help prevent flavour fatigue and improve compliance. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.0 Protein (% of total energy) 12.0 Fat (% of total energy) 44.2 Carbohydrate (% of total energy) 43.8 Total Cal:g nitrogen ratio 208:1 Non-protein Cal:g nitrogen ratio 183:1 Water (g/l) 854 Osmolality (mosm/kg water) 310 Renal solute load (mosm/l) 275 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ 10/8 pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use PediaSure, Vanilla 235-mL cans 12/case PediaSure, Strawberry 235-mL cans 12/case PediaSure, Chocolate 235-mL cans 12/case REFERENCES: 1. Feller AG et al. Subnormal concentrations of serum selenium and plasma carnitine in chronically tube-fed patients. Am J Clin Nutr 1987;45: Fischer MH et al. Improved selenium carnitine and taurine status in an enterally fed population. JPEN 1990;14: Bourdet B et al. Plasma Free Carnitine Depletion in Polytrauma Patients. J Nutr Health Aging 2010;14(3): Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton PediaSure Product Monograph, October

91 ENERGY Per 100 ml Per 235 ml ENERGY (Cal [kj]) 100 (419) 235 (984) PROTEIN (g) % of total energy 12.0 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Sodium caseinate, whey protein concentrate FAT (g) % of total energy 44.2 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) Docosahexaenoic acid (DHA) (g) - - Omega-6:Omega-3 ratio 11:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, soy oil, MCT oil MCT oil (% of total fats) 19.5 CARBOHYDRATE (g) % of total energy 43.8 Total dietary fibre (g) - - Short-chain fructooligosaccharides - - (scfos) (g) Galactooligosaccharides (GOS) (g) - - Corn maltodextrin, sucrose Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 78 (259) 182 (608) Vitamin D3 (mcg [IU]) 0.8 (32.0) 1.9 (75.2) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) - - MINERALS Sodium (mg [mmol]) 37 (1.61) 87 (3.78) Potassium (mg [mmol]) 130 (3.33) 306 (7.85) Chloride (mg [mmol]) 101 (2.85) 238 (6.71) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION Nutritional information for PediaSure, Vanilla, 235-mL can INGREDIENTS PediaSure, Vanilla: Water, maltodextrin, sucrose, sodium caseinate, high oleic safflower oil, soy oil, medium chain triglycerides (modified coconut oil and/or palm kernel oil), whey protein concentrate, calcium phosphate, natural and artificial flavour, potassium citrate, magnesium chloride, potassium phosphate, potassium chloride, monoglycerides, soy lecithin, choline chloride, carrageenan, ascorbic acid, potassium hydroxide, taurine, dl-α-tocopheryl acetate, ferrous sulphate, zinc sulphate, niacinamide, L-carnitine, d-calcium pantothenate, manganese sulphate, citric acid, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, cupric sulphate, vitamin A palmitate, folic acid, biotin, potassium iodide, sodium molybdate, sodium selenite, phylloquinone, cyanocobalamin, vitamin D3. May contain sodium citrate. Contains: milk ingredients.. CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, natural and artificial flavour, lactose, other soy components. Additional ingredient for chocolate: Dutch process cocoa. Additional ingredient for strawberry: Colour. Ingredients associated with food intolerances and/ or sensitivities: Colour. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIASURE Sole-source nutrition For children 1 to 13 years of age

92 PEDIASURE FIBRE Sole-source nutrition For children 1 to 13 years of age INDICATIONS FOR USE For children: - Who may benefit from dietary fibre. - Requiring short- or long-term tube feeding. - With increased nutrient needs. - With or at risk for malnutrition. - With failure to thrive. For oral or tube feeding use. Can be used as a supplement or as a sole source of nutrition. Safety precautions: Not for parenteral use. Not for children with galactosemia. For children under 1 year of age, consult a physician or qualified health care professional prior to using PediaSure Fibre. FEATURES AND BENEFITS Provides 1.1 g of dietary fibre per 235 ml. Fortified with taurine and carnitine to help prevent deficiencies associated with long-term tube feeding % of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source :1 Ca:P ratio to help optimize calcium and phosphorus balance. 5 Provides 27 vitamins and minerals. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.0 Protein (% of total energy) 12.2 Fat (% of total energy) 44.8 Carbohydrate (% of total energy) 43.0 Total Cal:g nitrogen ratio 206:1 Non-protein Cal:g nitrogen ratio 181:1 Water (g/l) 854 Osmolality (mosm/kg water) 345 Renal solute load (mosm/l) 275 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ 10/8 pump feeding (Fr) Low residue Gluten-free Kosher Halal No AVAILABILITY Ready to use PediaSure Fibre, Vanilla 235-mL cans 12/case REFERENCES: 1. Feller AG et al. Subnormal concentrations of serum selenium and plasma carnitine in chronically tube-fed patients. Am J Clin Nutr 1987;45: Fischer MH et al. Improved selenium carnitine and taurine status in an enterally fed population. JPEN 1990;14: Bourdet B et al. Plasma Free Carnitine Depletion in Polytrauma Patients. J Nutr Health Aging 2010;14(3): Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton PediaSure Product Monograph, October

93 ENERGY Per 100 ml Per 235 ml ENERGY (Cal [kj]) 100 (419) 235 (984) PROTEIN (g) % of total energy 12.2 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Sodium caseinate, whey protein concentrate FAT (g) % of total energy 44.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) Docosahexaenoic acid (DHA) (g) - - Omega-6:Omega-3 ratio 11:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, soy oil, MCT oil MCT oil (% of total fats) 19.5 CARBOHYDRATE (g) % of total energy 43.0 Total dietary fibre (g) Short-chain fructooligosaccharides - - (scfos) (g) Galactooligosaccharides (GOS) (g) - - Corn maltodextrin, sucrose, soy polysaccharide Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 78 (259) 182 (608) Vitamin D3 (mcg [IU]) 0.80 (32.0) 1.88 (75.2) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) - - MINERALS Sodium (mg [mmol]) 37 (1.61) 87 (3.78) Potassium (mg [mmol]) 130 (3.33) 306 (7.85) Chloride (mg [mmol]) 101 (2.85) 238 (6.71) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS PediaSure Fibre, Vanilla: Water, corn maltodextrin, sucrose, sodium caseinate, high oleic safflower oil, soy oil, medium chain triglycerides (modified coconut oil and/or palm kernel oil), whey protein concentrate, soy polysaccharide, calcium phosphate, natural and artificial flavour, potassium citrate, magnesium chloride, potassium phosphate, potassium chloride, monoglycerides, soy lecithin, choline chloride, carrageenan, ascorbic acid, potassium hydroxide, taurine, dl-α-tocopheryl acetate, ferrous sulphate, zinc sulphate, niacinamide, L-carnitine, d-calcium pantothenate, manganese sulphate, citric acid, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, cupric sulphate, vitamin A palmitate, folic acid, biotin, potassium iodide, sodium molybdate, sodium selenite, phylloquinone, cyanocobalamin, vitamin D3. May contain sodium citrate. Contains: milk and soy ingredients. CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, natural and artificial flavour, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIASURE FIBRE Sole-source nutrition For children 1 to 13 years of age

94 PEDIASURE PLUS (WITH FIBRE) Sole-source nutrition For children 1 to 13 years of age INDICATIONS FOR USE For children: - With fluid restrictions or volume sensitivity. - Who may benefit from dietary fibre. - Requiring short- or long-term tube feeding. - With increased nutrient needs. - With or at risk for malnutrition. - With failure to thrive. For oral or tube feeding use. Can be used as a supplement or as a sole source of nutrition. Safety precautions: Not for parenteral use. Not for children with galactosemia. For children under 1 year of age, consult a physician or qualified health care professional prior to using Pediasure Plus (with fibre). FEATURES AND BENEFITS Increased nutrient density provides more calories in less volume: 118 more calories per serving than PediaSure. Provides 1.76 g of dietary fibre per 235-mL. Contains 0.82 g of short-chain fructooligosaccharides (scfos) per 235-mL serving. Fortified with taurine and carnitine to help prevent deficiencies associated with long-term tube feeding % of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 4 Provides 27 vitamins and minerals. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.5 Protein (% of total energy) 11.0 Fat (% of total energy) 43.3 Carbohydrate (% of total energy) 45.7 Total Cal:g nitrogen ratio 232:1 Non-protein Cal:g nitrogen ratio 207:1 Water (g/l) 778 Osmolality (mosm/kg water) 387 Renal solute load (mosm/l) 348 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ 10/8 pump feeding (Fr) Low residue No Gluten-free No Kosher Halal AVAILABILITY Ready to use PediaSure Plus 235-mL cans 12/case (with fibre), Vanilla REFERENCES: 1. Feller AG et al. Subnormal concentrations of serum selenium and plasma carnitine in chronically tubefed patients. Am J Clin Nutr 1987;45: Fischer MH et al. Improved selenium carnitine and taurine status in an enterally fed population. JPEN 1990;14: Bourdet B et al. Plasma Free Carnitine Depletion in Polytrauma Patients. J Nutr Health Aging 2010;14(3): Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

95 ENERGY Per 100 ml Per 235 ml ENERGY (Cal [kj]) 150 (628) 353 (1476) PROTEIN (g) % of total energy 11.0 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Sodium and calcium caseinates, whey protein concentrate FAT (g) % of total energy 43.3 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) Docosahexaenoic acid (DHA) (g) - - Omega-6:Omega-3 ratio 11:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, soy oil, MCT oil MCT oil (% of total fats) 19.6 CARBOHYDRATE (g) % of total energy 45.7 Total dietary fibre (g) charides (scfos) (g) Short-chain fructooligosac Galactooligosaccharides (GOS) (g) - - Corn maltodextrin, sucrose, scfos, modified oat hulls, soy cotyledon fibre, gum arabic, carboxymethylcellulose Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 99 (330) 233 (776) Vitamin D3 (mcg [IU]) 1.13 (45) 2.65 (106) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 65 (2.83) 153 (6.65) Potassium (mg [mmol]) 180 (4.62) 423 (10.85) Chloride (mg [mmol]) 122 (3.44) 287 (8.10) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS PediaSure Plus (with fibre), Vanilla: Water, corn maltodextrin, high oleic safflower oil, sodium caseinate, soy oil, sucrose, medium chain trigly cerides (modified coconut oil and/or palm kernel oil), calcium caseinate, whey protein concentrate, potassium citrate, short-chain fructooligosaccharides, modified oat hulls, soy cotyledon fibre, natural and artificial flavour, calcium phosphate, magnesium chloride, gum arabic, potassium phosphate, monoglycerides, soy lecithin, sodium carboxymethyl cellulose, sodium citrate, choline chloride, sodium chloride, ascorbic acid, taurine, m-inositol, potassium chloride, ferrous sulphate, zinc sulphate, niacinamide, L-carnitine, dl-α-tocopheryl acetate, d-calcium pantothenate, cupric sulphate, citric acid, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, manganese sulphate, vitamin A palmitate, folic acid, biotin, potassium iodide, chromium chloride, sodium molybdate, phylloquinone, sodium selenate, vitamin D3, cyanocobalamin. May contain potassium hydroxide. Contains: milk and soy ingredients. CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, gluten, natural and artificial flavour, lactose, other soy components. Products containing oat fibre cannot be considered gluten-free. Fructooligosaccharides (FOS) have been listed as an accepted source of dietary fibre by Health Canada in April Labels will be revised accordingly as part of Abbott Nutrition s ongoing label review. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIASURE PLUS (WITH FIBRE) Sole-source nutrition For children 1 to 13 years of age

96 PEDIASURE PEPTIDE 1 CAL Specialized peptide-based liquid formula For children 1 to 13 years of age Great-tasting product INDICATIONS FOR USE PediaSure Peptide 1 Cal is a ready-to-drink peptide-based liquid formula for children with impaired gastro-intestinal function. It offers flexibility to meet nutritional needs both orally or as a tube feeding. For children with: - GI disease: pancreatitis (acute or chronic) or pancreatic insufficiency; cystic fibrosis; Crohn s disease, ulcerative colitis or short bowel syndrome; HIV/AIDS-associated enteropathy; celiac disease; gastritis, duodenitis, enterocolitis; dumping syndrome; GI fistulas. - GI intolerance symptoms: gas, bloating, diarrhea and abdominal distention. - Acute GI dysfunction: critical illness; trauma; burns; sepsis; post-transplant surgery; post-gastric surgery. - Impaired GI function: abdominal and other surgeries; certain cancer treatments; generalized malabsorption; general intolerance to polymeric feedings; cerebral palsy. Can be used: - As a supplement or as a sole source of nutrition; for early enteral feeding; for dual feeding (parenteral + enteral); for transition from total parenteral nutrition (TPN); for trophic feeding. For oral or tube feeding use. Safety precautions: Not for parenteral use. Not for children with galactosemia. Health care professional clinical judgment is required for use in children under 1 year of age. FEATURES AND BENEFITS Nutrient blend designed to help support tolerance and absorption: - 100% hydrolyzed protein; - 50% of fat as medium-chain triglycerides (MCT), an easily digested and well-absorbed fat source. 1 Contains 1 g of short-chain fructooligosaccharides (scfos) fibre per 237-mL serving. 27 vitamins and minerals. Convenient, reclosable bottle. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.0 Protein (% of total energy) 12.0 Fat (% of total energy) 35.0 Carbohydrate (% of total energy) 53.0 Total Cal:g nitrogen ratio 208:1 Non-protein Cal:g nitrogen ratio 183:1 Water (g/l) 844 Osmolality (mosm/kg water) 390 Renal solute load (mosm/l) 265 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ 10/8 pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use PediaSure Peptide 1 Cal, Vanilla 237-mL bottles 24/case REFERENCE: 1. Duggan C, Watkins JB, Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

97 ENERGY Per 100 ml Per 237 ml ENERGY (Cal [kj]) 100 (418) 237 (992) PROTEIN (g) 3 7 % of total energy 12.0 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Whey protein hydrolysate, hydrolyzed sodium caseinate FAT (g) 4 10 % of total energy 35.0 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) Docosahexaenoic acid (DHA) (g) - - Omega 6:Omega 3 ratio 2.7:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Structured lipid (interesterified canola oil and mediumchain triglycerides) MCT oil (% of total fats) 50 CARBOHYDRATE (g) % of total energy 53.0 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) - - Corn maltodextrin, sucrose Acesulfame-potassium (mg) - - Sucralose (mg) 6 14 VITAMINS Vitamin A (RE [IU]) 75 (250) (592) Vitamin D3 (mcg [IU]) 1.33 (53.0) 3.13 (125) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) - - MINERALS Sodium (mg [mmol]) 70 (3.04) 170 (7.39) Potassium (mg [mmol]) 135 (3.46) 320 (8.21) Chloride (mg [mmol]) 101 (2.85) 240 (6.77) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS PediaSure Peptide 1 Cal, Vanilla: Water, corn maltodextrin, sucrose, whey protein hydrolysate, structured lipid (interesterified canola oil and medium chain triglycerides*), hydrolyzed sodium caseinate, MINERALS (calcium phosphate, potassium citrate, magnesium phosphate, potassium chloride, magnesium chloride, sodium citrate, ferrous sulphate, zinc sulphate, manganese sulphate, cupric sulphate, chromium chloride, potassium iodide, sodium selenate, sodium molybdate), medium chain triglycerides*, canola oil, short-chain fructooligosaccharides, natural and artificial flavours, VITAMINS (ascorbic acid, choline chloride, m-inositol, dl-α tocopheryl acetate, d-calcium pantothenate, niacinamide, thiamine chloride hydrochloride, pyridoxine hydrochloride, riboflavin, vitamin A palmitate, folic acid, biotin, phylloquinone, cyanocobalamin, vitamin D3), cellulose gel, soy lecithin, carrageenan, sucralose, cellulose gum, taurine, L-carnitine. Contains: milk and soy ingredients. Not suitable for individuals with galactosemia. * Modified coconut oil and/or palm kernel oil. CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, natural and artificial flavours, lactose, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIASURE PEPTIDE 1 CAL Specialized peptide-based liquid formula For children 1 to 13 years of age

98 NOTES:

99 IN THIS SECTION Pedialyte Pedialyte AdvancedCareTM Pedialyte Powder Sachets Pedialyte Freezer Pops Pedialyte (HFS) Similac 5% Glucose Water (HFS) Similac Sterilized Water (HFS) RCF Specialty Products SPECIALTY PRODUCTS

100 Specialty Products SPECIALTY PRODUCTS

101 DOSAGE CHART (PEDIALYTE ) This chart suggests the daily dosage requirements of Pedialyte in millilitres. The volume necessary is based on the child s weight ( ml/kg 1 or approximately Freezer Pops/kg). Pedialyte should be offered in small frequent sips every 15 minutes, increasing serving size as tolerated. Total daily intake should be adjusted to meet individual needs, based on thirst and response to therapy. The suggested intakes for maintenance are based on water requirements for ordinary energy expenditure. 2 Dosage chart does not apply to infants younger than 1 week of age. For children older than 4 years of age, maintenance intakes may exceed 2 litres (32 or more Freezer Pops) daily. If there is vomiting or fever, or if diarrhea continues beyond 24 hours, consult the child s physician. Body Weight Pedialyte ml/day for maintenance 3 kg (6.6 lb) kg (8.8 lb) kg (11.0 lb) kg (13.2 lb) kg (15.4 lb) kg (17.6 lb) kg (19.8 lb) kg (22.0 lb) kg (24.2 lb) kg (26.4 lb) kg (28.6 lb) kg (30.8 lb) kg (33.0 lb) kg (35.2 lb) kg (37.4 lb) kg (39.6 lb) kg (41.8 lb) kg (44.0 lb) NOTE: 4 Freezer Pops = 250 ml = 1 cup. Fluid intake is total fluid requirement from oral electrolyte solution, formula, or other fluids, but does not take into account ongoing stool losses. Fluid loss in the stools should be replaced by consumption of an extra amount of Pedialyte equal to stool losses, in addition to the fluid maintenance requirement in this dosage chart. Pedialyte products are to be used with other appropriate fluids to help prevent dehydration. REFERENCES: 1. Leung A, Prince T. Canadian Paediatric Society Nutrition and Gastroenterology Committee Paediatr Child Health Oral rehydration therapy and early refeeding in the management of childhood gastroenteritis 2006;11(8): Extrapolated from Barness LA, Curran JS: Nutrition, in Nelson WE (sr ed), Behrman RE, Kliegman RM, Arvin AM (eds): Nelson Textbook of Pediatrics, ed 15. Philadelphia: WB Saunders Co, 1996, pp

102 PEDIALYTE Oral rehydration solution for all ages Now with zinc INDICATIONS FOR USE Pedialyte is specially formulated to help prevent dehydration in children and adults by restoring nutrients lost during diarrhea and vomiting. Can be used for maintenance of water and electrolytes following corrective parenteral therapy for diarrhea. Safety precautions: Not for parenteral use. For infants under 1 year, consult a physician or qualified health care professional before using Pedialyte as infants and young children are at greater risk of dehydration. FEATURES AND BENEFITS #1 brand recommended by pediatricians. Provides glucose to promote sodium and water absorption. Contains the balance of sodium and sugar recommended by experts 1,2 to help prevent dehydration due to diarrhea and vomiting. Helps replenish zinc lost during diarrhea. 3,4 Promotes fluid absorption more effectively than common household beverages. Low osmolality. 1-L reclosable bottles for easy measuring and pouring. Unflavoured liquid available for infants no artifical sweeteners, dyes or flavours. 2 delicious flavours to encourage compliance. TECHNICAL DATA Ready to use Unflavoured Ready to use Flavoured Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio Non-protein Cal:g nitrogen ratio Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Pedialyte Unflavoured 1-L reclosable 8/case plastic bottles Pedialyte Grape 1-L reclosable 8/case plastic bottles Pedialyte Fruit 1-L reclosable 8/case plastic bottles REFERENCES: 1. World Health Organization. Oral Rehydration Salts: Production of the new ORS Leung A, Prince T. Oral Rehydration therapy and early refeeding in the management of childhood gastroenteritis. Canadian Paediatric Society Nutrition and Gastroenterology Committee. Paediatr Child Health 2006;11(8): Bhatnagar S et al. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. Journal of Pediatric Gastroenterology and Nutrition 2004;38(1): Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics 2008;121(2):

103 ENERGY Per 100 ml Per 1000 ml ENERGY (Cal [kj]) 10 (42) 100 (418) MEDICINAL INGREDIENTS Dextrose (g) Sodium (mg [mmol]) 104 (4.5) 1035 (45) Potassium (mg [mmol]) 78.2 (2.0) 782 (20) Chloride (mg [mmol]) 124 (3.5) 1240 (35) Zinc (mg) Citrate (g [mmol]) 0.26 (1.4) 2.6 (14) OTHER (flavoured only) Acesulfame-potassium (mg) Sucralose (mg) INGREDIENTS Pedialyte, Unflavoured: MEDICINAL INGREDIENTS: Dextrose, potassium citrate, sodium chloride, sodium citrate, citric acid, zinc gluconate. NON-MEDICINAL INGREDIENS: Water. CONTAINS: Ingredient associated with food intolerances and/or sensitivities: Citric acid. Pedialyte, Grape: MEDICINAL INGREDIENTS: Dextrose, citric acid, potassium citrate, sodium chloride, sodium citrate, zinc gluconate. NON-MEDICINAL INGREDIENTS: Water, artificial flavour, sucralose, acesulfame-potassium, FD&C Red N o 40, FD&C Blue N o 1. CONTAINS: Ingredients associated with food intolerances and/or sensitivities: Citric acid, colours, natural and artificial flavours. NUTRITIONAL INFORMATION Pedialyte, Fruit: MEDICINAL INGREDIENTS: Dextrose, citric acid, potassium citrate, sodium chloride, sodium citrate, zinc gluconate. NON-MEDICINAL INGREDIENTS: Water, natural and artificial flavours, sucralose, acesulfamepotassium, FD&C Yellow N o 6. CONTAINS: Ingredients associated with food intolerances and/or sensitivities: Citric acid, colours, natural and artificial flavours. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIALYTE Oral rehydration solution for all ages

104 PEDIALYTE ADVANCEDCARE TM Oral rehydration solution for all ages INDICATIONS FOR USE Pedialyte AdvancedCare TM is specially formulated to help prevent dehydration in children and adults by restoring nutrients lost during diarrhea and vomiting. Can be used for maintenance of water and electrolytes following corrective parenteral therapy for diarrhea. Safety precautions: Not for parenteral use. Not for children with milk allergy, GOS allergy or galactosemia. For infants under 1 year, consult a physician or qualified health care professional before using Pedialyte as infants and young children are at greater risk of dehydration. FEATURES AND BENEFITS #1 brand recommended by pediatricians. Provides glucose to promote sodium and water absorption. Contains the balance of sodium and sugar recommended by experts 1,2 to help prevent dehydration due to diarrhea and vomiting. Contains PreActiv TM prebiotics in the form of galactooligosaccharides (GOS). Helps replenish zinc lost during diarrhea. 3,4 Promotes fluid absorption more effectively than common household beverages. Low osmolality. 1-L reclosable bottles for easy measuring and pouring. 2 delicious flavours to encourage compliance. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.07 Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) 100 Total Cal:g nitrogen ratio Non-protein Cal:g nitrogen ratio Water (g/l) 970 Osmolality (mosm/kg water) 226 Renal solute load (mosm/l) 100 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal Cherry Punch No Blue Raspberry AVAILABILITY Ready to use Pedialyte AdvancedCare TM, Cherry Punch 1-L bottles 8/case Pedialyte AdvancedCare TM, Blue Raspberry 1-L bottles 8/case GOS (galactooligosaccharides) are a type of fibre that helps stimulate the growth of good bacteria in the large intestine, helping promote digestive health. REFERENCES: 1. World Health Organization. Oral Rehydration Salts: Production of the new ORS Leung A, Prince T. Oral Rehydration therapy and early refeeding in the management of childhood gastroenteritis. Canadian Paediatric Society Nutrition and Gastroenterology Committee. Paediatr Child Health 2006;11(8): Bhatnagar S et al. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. Journal of Pediatric Gastroenterology and Nutrition 2004;38(1): Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics 2008;121(2):

105 ENERGY Per 100 ml Per 1000 ml ENERGY (Cal [kj]) 7 (29.3) 70 (293) MEDICINAL INGREDIENTS Dextrose (g) Galactooligosaccharides (GOS) (g) Sodium (mg [mmol]) 103 (4.5) 1030 (45) Potassium (mg [mmol]) 78.2 (2.0) 782 (20) Chloride (mg [mmol]) 124 (3.5) 1244 (35) Zinc (mg) Citrate (g [mmol]) 0.48 (2.55) 4.8 (25.5) OTHER Acesulfame-potassium (mg) Sucralose (mg) INGREDIENTS Pedialyte AdvancedCareTM, Cherry Punch: MEDICINAL INGREDIENTS: Dextrose, galactooligosaccharides, citric acid, potassium citrate, sodium chloride, sodium citrate, zinc gluconate. NON-MEDICINAL INGREDIENTS: Water, natural and artificial flavour, sucralose, acesulfamepotassium, FD&C Red N o 40. CONTAINS: Ingredient associated with food intolerances and/or sensitivities: Milk, citric acid, colours, natural and artificial flavours. Pedialyte AdvancedCareTM, Blue Raspberry: MEDICINAL INGREDIENTS: Dextrose, galactooligosaccharides, citric acid, potassium citrate, sodium chloride, sodium citrate, zinc gluconate. NON-MEDICINAL INGREDIENTS: Water, natural and artificial flavours, sucralose, acesulfamepotassium, FD&C Blue N o 1, FD&C Red N o 40. CONTAINS: Ingredients associated with food intolerances and/or sensitivities: Milk, citric acid, colours, natural and artificial flavours. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIALYTE ADVANCEDCARE TM Oral rehydration solution for all ages

106 PEDIALYTE Powder Sachets Oral rehydration solution for all ages INDICATIONS FOR USE Pedialyte is specially formulated to help prevent dehydration in children and adults by restoring nutrients lost during diarrhea and vomiting. Can be used for maintenance of water and electrolytes following corrective parenteral therapy for diarrhea. Safety precautions: Not for parenteral use. For infants under 1 year, consult a physician or qualified health care professional before using Pedialyte as infants and young children are at greater risk of dehydration. FEATURES AND BENEFITS #1 brand recommended by pediatricians. When mixed with 250 ml of water: - Provides glucose to promote sodium and water absorption. - Contains the balance of sodium and sugar recommended by experts 1,2 to help prevent dehydration due to diarrhea and vomiting. - Promotes fluid absorption more effectively than common household beverages. Low osmolality. Convenient powder format. 2 delicious flavours to encourage compliance. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.10 Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) 100 Total Cal:g nitrogen ratio Non-protein Cal:g nitrogen ratio Water (g/l) 970 Osmolality (mosm/kg water) 265 Renal solute load (mosm/l) 80 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder Pedialyte powder, Apple 8 x 8.5-g sachets 8/case Pedialyte powder, Fruit Punch 8 x 8.5-g sachets 8/case REFERENCES: 1. World Health Organization. Oral Rehydration Salts: Production of the new ORS Leung A, Prince T. Oral Rehydration therapy and early refeeding in the management of childhood gastroenteritis. Canadian Paediatric Society Nutrition and Gastroenterology Committee. Paediatr Child Health 2006; 11(8):

107 ENERGY Per 250 ml (at standard dilution) ENERGY (Cal [kj]) 23 (96) MEDICINAL INGREDIENTS Dextrose (g) 5.7 Sodium (mg [mmol]) 244 (10.6) Potassium (mg [mmol]) 184 (4.7) Chloride (mg [mmol]) 294 (8.3) Citrate (g [mmol]) 1.15 (6.1) OTHER Acesulfame-potassium (mg) 20 Sucralose (mg) 25 INGREDIENTS Pedialyte Apple, powder: MEDICINAL INGREDIENTS: Dextrose, citric acid, potassium citrate, sodium chloride, sodium citrate. NON-MEDICINAL INGREDIENTS: Malic acid, artificial apple flavour, caramel colour, sucralose, acesulfame-potassium. CONTAINS: Ingredients associated with food intolerances and/or sensitivities: Citric acid, colours, natural and artificial flavours. Pedialyte Fruit Punch, powder: MEDICINAL INGREDIENTS: Dextrose, citric acid, potassium citrate, sodium chloride, sodium citrate. NON-MEDICINAL INGREDIENTS: Malic acid, natural and artificial fruit punch flavour, sucralose, acesulfame-potassium, FD&C Red N o 40. CONTAINS: Priority Food Allergens: Ingredients associated with food intolerances and/or sensitivities: Citric acid, colours, natural and artificial flavours. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIALYTE Powder Sachets Oral rehydration solution for all ages

108 PEDIALYTE Freezer Pops Oral rehydration solution for all ages INDICATIONS FOR USE Pedialyte is specially formulated to help prevent dehydration in children and adults by restoring nutrients lost during diarrhea and vomiting. Can be used for maintenance of water and electrolytes following corrective parenteral therapy for diarrhea. Safety precautions: Not for parenteral use. For infants under 1 year, consult a physician or qualified health care professional before using Pedialyte as infants and young children are at greater risk of dehydration. FEATURES AND BENEFITS #1 brand recommended by pediatricians. Provides glucose to promote sodium and water absorption. Contains the balance of sodium and sugar recommended by experts 1,2 to help prevent dehydration due to diarrhea and vomiting. Promotes fluid absorption more effectively than common household beverages. Low osmolality. 4 delicious flavours to enhance compliance. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.10 Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) 100 Total Cal:g nitrogen ratio Non-protein Cal:g nitrogen ratio Water (g/l) 973 Osmolality (mosm/kg water) 270 Renal solute load (mosm/l) 100 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal No AVAILABILITY Ready to use Pedialyte Freezer Pops, 16 x 62.5-mL 8 x 16/case Variety Pack sleeves Grape, Cherry, Orange, and Blue Raspberry. REFERENCES: 1. World Health Organization. Oral Rehydration Salts Production of the new ORS Leung A, Prince T. Oral Rehydration therapy and early refeeding in the management of childhood gastroenteritis. Canadian Paediatric Society Nutrition and Gastroenterology Committee. Paediatr Child Health 2006;11(8):

109 ENERGY Per 62.5 ml Freezer Pop ENERGY (Cal [kj]) 6.3 (26.4) MEDICINAL INGREDIENTS Dextrose (g) 1.6 Sodium (mg [mmol]) 64.8 (2.8) Potassium (mg [mmol]) 48.8 (1.3) Chloride (mg [mmol]) 77.8 (2.2) Citrate (g [mmol]) (0.6) OTHER Acesulfame-potassium (mg) 9.4 Sucralose (mg) 12.5 INGREDIENTS Pedialyte Freezer Pops, Grape, Cherry, Orange and Blue Raspberry: MEDICINAL INGREDIENTS: Sodium (sodium chloride, sodium citrate), potassium (potassium citrate), chloride (sodium chloride). NON-MEDICINAL INGREDIENTS: Water, dextrose, citric acid, sodium carboxymethylcellulose, potassium sorbate, sodium benzoate, sucralose and acesulfame potassium. CONTAINS: Ingredients associated with food intolerances and/or sensitivities: Citric acid, colours, natural and artificial flavours. Additional ingredients for Grape: Natural and artificial grape flavour, FD&C Red N o 40 and FD&C Blue N o 1. NUTRITIONAL INFORMATION Additional ingredients for Cherry: Natural and artificial cherry flavour and FD&C Red N o 40. Additional ingredients for Orange: Natural and artificial orange flavour, FD&C Yellow N o 6 and FD&C Red N o 40. Additional ingredients for Blue Raspberry: Natural and artificial blue raspberry flavour and FD&C Blue N o 1. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIALYTE Freezer Pops Oral rehydration solution for all ages

110 PEDIALYTE Oral rehydration solution Now with zinc INDICATIONS FOR USE For infants and children at risk for dehydration. For infants and children with diarrhea and/or vomiting. - To help prevent dehydration. - To help replace fluids, electrolytes and zinc lost during diarrhea and vomiting. - For maintenance of water and electrolytes following corrective parenteral therapy. For oral or tube feeding use. Safety precautions: Not for parenteral use. For use under medical supervision. Infants and young children are at greater risk of dehydration. FEATURES AND BENEFITS Designed to prevent dehydration more effectively than common household beverages. Provides glucose to promote sodium and water absorption. Restores electrolytes lost during diarrhea and vomiting to help prevent dehydration. Helps replenish zinc lost during diarrhea. 1,2 Low osmolality. Unflavoured for infants. Ready to use no mixing or dilution necessary. TECHNICAL DATA Ready to use Unflavoured Caloric density (Cal/mL) 0.10 Protein (% of total energy) 0 Fat (% of total energy) 0 Carbohydrate (% of total energy) 100 Total Cal:g nitrogen ratio Non-protein Cal:g nitrogen ratio Water (g/l) 978 Osmolality (mosm/kg water) 250 Renal solute load (mosm/l) 100 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Pedialyte Unflavoured 59-mL plastic 48/case bottles REFERENCES: 1. Bhatnagar S et al. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. Journal of Pediatric Gastroenterology and Nutrition 2004;38(1): Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics 2008;121(2):

111 ENERGY Per 100 ml Per 59 ml ENERGY (Cal [kj]) 10 (42) 5.9 (24.7) MEDICINAL INGREDIENTS Dextrose (g) Sodium (mg [mmol]) 104 (4.5) 61.4 (2.7) Potassium (mg [mmol]) 78.2 (2.0) 46.1 (1.2) Chloride (mg [mmol]) 124 (3.5) 73.2 (2.1) Zinc (mg) Citrate (mg [mmol]) 0.26 (1.4) 0.15 (0.8) INGREDIENTS Pedialyte, Unflavoured: MEDICINAL INGREDIENTS: Dextrose, potassium citrate, sodium chloride, sodium citrate, citric acid, zinc gluconate. NON-MEDICINAL INGREDIENTS: Water. CONTAINS: Ingredients associated with food intolerances and/or sensitivities: Citric acid. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIALYTE Oral rehydration solution

112 SIMILAC 5% GLUCOSE WATER INDICATIONS FOR USE For initial or supplemental feeding. For oral feeding only not for tube feeding. Safety precaution: Use under medical supervision. FEATURES AND BENEFITS Ready to use No mixing or dilution necessary. TECHNICAL DATA Bottle Caloric density (Cal/mL) 0.2 Protein (% of total energy) 0 Fat (% of total energy) 0 Carbohydrate (% of total energy) 100 Total Cal:g nitrogen ratio Non-protein Cal:g nitrogen ratio Water (%) 96.6 Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac 5% Glucose Water 59-mL plastic 48/case bottles ENERGY Per 100 ml Per 100 Cal Per 1000 ml Per 59 ml ENERGY (Cal [kj]) 20 (85) 100 (418) 200 (837) 12 (50) CARBOHYDRATE (g) % of total energy 100 Dextrose INGREDIENTS Similac 5% Glucose Water, Ready to use: Water and anhydrous dextrose. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. 112

113 SIMILAC STERILIZED WATER INDICATIONS FOR USE For initial or supplemental feeding. For oral feeding only not for tube feeding. Safety precaution: Use under medical supervision. FEATURES AND BENEFITS Ready to use No mixing or dilution necessary. TECHNICAL DATA Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio Non-protein Cal:g nitrogen ratio Bottle Water (%) 100 Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Sterilized Water 59-mL plastic 48/case bottles Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. 113

114 RCF No added carbohydrate soy-based iron-fortified formula INDICATIONS FOR USE For use in the dietary management of: - Patients unable to tolerate the type or amount of carbohydrate in milk or conventional infant formulas; - Patients with seizure disorders requiring a ketogenic diet. Safety precautions: Not for parenteral use. Use under medical supervision. FEATURES AND BENEFITS Formulated to allow the health care professional to prescribe the type and amount of carbohydrate that can be tolerated with the assurance that other nutrient needs will be met. Soy protein isolate to avoid symptoms of cow s milk-protein allergy or sensitivity. L-carnitine (3 mg/100 ml) and taurine (12 mg/100 ml). TECHNICAL DATA Concentrated Liquid Caloric density (Cal/mL) 0.81 Protein (% of total energy) 20 Fat (% of total energy) 80 Carbohydrate (% of total energy) 0 Total Cal:g nitrogen ratio 127:1 Non-protein Cal:g nitrogen ratio 101:1 Water (g/l) 880 Osmolality (mosm/kg water) 90 Renal solute load (mosm/l) 34.8 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Concentrated Liquid 00108B12 RCF 384-mL cans 12/case PREPARATION For 20 Cal/30 ml formula: Use the type and amount of carbohydrate specified by a health care professional (see table below). 1. Dissolve carbohydrate in 355 ml of water, cover and bring to a boil. Keep covered; allow to cool. 2. Rinse can lid and shake very well. Open with clean punch-type opener. 3. Add RCF to cooled carbohydrate solution prepared in step 1. Mix and pour into bottles (or cup). 4. Once feeding begins, use within 1 hour or discard. For 54 g of carbohydrate, add one of the following: Table sugar (sucrose) Fructose powder Dextrose powder (hydrous) 60 ml (4 level Tbsp) 60 ml (4 level Tbsp) 90 ml (6 level Tbsp) 114

115 ENERGY Per 100 ml (concentrated liquid) Per 100 Cal (standard dilution) ENERGY (Cal [kj]) 81 (339) 100 (418) PROTEIN (g) Soy protein isolate, L-methionine FAT (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) - - Docosahexaenoic acid (DHA) (g) - - Omega-6:Omega-3 ratio 10.6:1 Cholesterol (mg) 0 0 High oleic safflower oil, soy oil, coconut oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) Total dietary fibre (g) - - Short-chain fructooligosac- - - charides (scfos) (g) Galactooligosaccharides (GOS) (g) - - Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 122 (405) 90 (300) Vitamin D3 (mcg [IU]) 2.0 (81) 1.5 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) 12 9 Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) - - MINERALS Sodium (mg [mmol]) 59.1 (2.6) 44 (1.9) Potassium (mg [mmol]) 146 (3.7) 108 (2.8) Chloride (mg [mmol]) 83 (2.3) 62 (1.8) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) - - Molybdenum (mg) g of carbohydrate ml of water, mixed with 384 ml of RCF ; yields ~770 ml. NUTRITIONAL INFORMATION INGREDIENTS RCF, Concentrated liquid: Water (88%), soy protein isolate (5%), high oleic safflower oil (3%), soy oil (2%), Coconut oil (2%); less than 1% of: Calcium phosphate, potassium citrate, potassium chloride, magnesium chloride, monoglycerides, soy lecithin, carrageenan, salt, L-methionine, ascorbic acid, potassium hydroxide, choline chloride, taurine, m-inositol, ferrous sulfate, zinc sulfate, L-carnitine, niacinamide, d-alpha-tocopheryl acetate, calcium pantothenate, cupric sulfate, thiamine chloride hydrochloride, vitamin a palmitate, riboflavin, pyridoxine hydrochloride, folic acid, potassium iodide, phylloquinone, biotin, beta-carotene, sodium selenate, vitamin D3, and cyanocobalamin. CONTAINS: Priority Food Allergens: Soy. Ingredients associated with food intolerances and/or sensitivities: Coconut oil and other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. RCF No added carbohydrate soy-based iron-fortified infant formula

116 NOTES:

117 ACCESSORIES Accessories IN THIS SECTION Component Nipple System Plastic Bottle and Cap CustomFeed Bottle Volu-Feed Dispensing Cap

118 Accessories ACCESSORIES

119 COMPONENT NIPPLE SYSTEM Similac nipples are designed to be used with all Abbott Nutrition bottles, including: 120-mL and 59-mL Hospital Feeding System bottles. 240-mL plastic bottle. CustomFeed bottle. Similac Infant Nipple and Ring # (250/case) Description Product Composition Latex-free Designed for use with term infants or for infants Nipple: polyisoprene with developed sucking strength. Ring: polyethylene Similac Orthodontic Nipple and Ring # (250/case) Description Product Composition Latex-free Designed for newborn infants (term or preterm). Opening faces infant s palate and orthodontic design stimulates oral exercise while feeding. Nipple: natural rubber latex Ring: polyethylene No Similac Premature Nipple and Ring # (250/case) Description Product Composition Latex-free Designed for preterm infants with less developed Nipple: polyisoprene sucking strength. Decreased bulb wall thickness Ring: polyethylene increases pliability and makes it easier to suckle. Similac Slow Flow Nipple and Ring # (250/case) Description Product Composition Latex-free Designed to support the underdeveloped suck-swallow-breathe coordination of lowbirth-weight or preterm infants. Provides a more infant-driven, controlled flow rate vs. faster-flow nipples for increased physiological stability and a more efficient sucking pattern. 1 Nipple: polyisoprene Ring: polyethylene FEATURES AND BENEFITS Easy to use. Flexibility to choose a nipple that matches each infant s sucking strength or need. Nipples and rings are individually pre-packaged and ready for use. Nipples and rings form a seal to prevent leakage during feeding. Disposable not for re-use. WARNINGS DO NOT use as a pacifier, as it presents a choking hazard. DO NOT re-use, as re-use can cause deterioration or separation of the rubber, presenting a choking hazard. Keep out of reach of children. REFERENCE: 1. Chang YJ et al. Effects of Single-Hole and Cross-Cut Nipple Units on Feeding Efficiency and Physiological Parameters in Premature Infants. J Nurs Res 2007;150(3):

120 PLASTIC BOTTLE AND CAP Plastic Bottle # (144/case) Description Product Composition Latex-free Volume: 240 ml. Designed for use as a nursing bottle. Polypropylene COMPATIBLE WITH All Similac Nipples. Plastic Bottle Cap. FEATURES AND BENEFITS Ready to use. Food grade quality. Unbreakable; safe for pediatric nurseries. Dishwasher-safe (top rack). Disposable. Plastic Bottle Cap # (250/case) Description Product Composition Latex-free Standard 40 mm finish. Polypropylene COMPATIBLE WITH 120-mL and 59-mL Hospital Feeding System bottles. 240-mL plastic bottle. CustomFeed bottle. FEATURES AND BENEFITS Food grade quality. Dishwasher-safe (top rack). Can be prepared for use by placing in boiling water for 1 minute or washed in the top rack of a dishwasher. 120

121 CUSTOMFEED BOTTLE Breastmilk Storage Bottle with Cap Now Sterile CustomFeed Bottle # (100/case) Description Product Composition Latex-free Volume: 60 ml. When accurate measurement of breast milk or formula is needed, particularly with preterm and low birth weight infants. Polypropylene COMPATIBLE WITH Breast pumps that fit a standard size bottle. All Similac nipples. Plastic Bottle Cap. Volu-Feed Dispensing Cap. FEATURES AND BENEFITS 60-mL sterile bottle and cap (individually packaged together). Easy to read, graduated measurement (1 ml calibrations). Freezable. Disposable or reusable. Dishwasher safe (top rack only). Manufactured without BPA, latex, and DEHP. Volu-Feed Dispensing Cap # (250/case) Description Product Composition Latex-free Permits tube feeding using CustomFeed bottle by holding feeding tube in place. Polypropylene FEATURES AND BENEFITS Single use. Ready to use - individually packaged in a sealed, clean-peel blisterpack. Disposable. COMPATIBLE WITH CustomFeed Bottle. If the institution decides to reuse, follow Health Canada guidelines for sterilization. 121

122 NOTES:

123 ADDITIONAL INFORMATION Additional Information IN THIS SECTION Alberta Reimbursement List Ontario Reimbursement List Quebec Reimbursement List Saskatchewan Reimbursement List

124 Additional Information ADDITIONAL INFORMATION

125 ALBERTA REIMBURSEMENT LIST The following Abbott nutritional products are listed on the Alberta Human Services Drug Benefit Supplement. PIN Description Format REGULAR (UNRESTRICTED) BENEFITS Ensure Regular, All flavours 235-mL bottles Ensure Fibre, All flavours 235-mL cans Ensure Plus Calories, All flavours 235-mL bottles Ensure Plus, All flavours 235-mL cans Ensure scfos Fibre, All flavours 235-mL bottles Glucerna nutritional drink, All flavours 237-mL bottles PediaSure Peptide 1 Cal, Vanilla 237-mL bottles Jevity 1 Cal, Unflavoured 235-mL cans Nepro, Vanilla 237-mL bottles Nepro, Vanilla 1000-mL RTH containers Pedialyte, Flavoured 1-L bottles Pedialyte, Unflavoured 1-L bottles PediaSure, All flavours 235-mL cans PediaSure Fibre, Vanilla 235-mL cans Similac Alimentum, Unflavoured 237-mL cans Similac Alimentum with DHA, 400-g cans Unflavoured Similac Neosure, Unflavoured 363-g cans Suplena, Vanilla 235-mL cans Vital Peptide 1 Cal, Vanilla 220-mL bottles Vital Peptide 1.5 Cal, Vanilla 220-mL bottles Vital Peptide 1.5 Cal, Vanilla 1000-mL RTH containers SPECIAL AUTHORIZATION Ensure High Protein, All flavours 235-mL bottles Ensure pudding, All flavours 113-g cups Jevity 1.2 Cal, Unflavoured 235-mL cans Jevity 1.2 Cal, Unflavoured 1000-mL RTH containers Jevity 1.2 Cal, Unflavoured 1500-mL RTH containers Jevity 1.5 Cal, Unflavoured 235-mL cans Jevity 1.5 Cal, Unflavoured 1000-mL RTH containers Jevity 1.5 Cal, Unflavoured 1500-mL RTH containers PediaSure Plus (with fibre), Vanilla 235-mL cans TwoCal HN, Vanilla 235-mL cans TwoCal HN, Vanilla 1000-mL RTH containers For more information, visit: RTH = Ready-to-hang 125

126 ONTARIO REIMBURSEMENT LIST The following Abbott nutritional products are listed on the Ontario Drug Benefit (ODB) Formulary. PIN Description Format ADULT Ensure Fibre, Vanilla 235-mL cans Ensure Fibre, Chocolate 235-mL cans Ensure Plus, Vanilla 235-mL cans Ensure Plus, Chocolate 235-mL cans Ensure Plus, Strawberry 235-mL cans Glucerna 1.0 Cal, Vanilla 235-mL cans Jevity 1 Cal, Unflavoured 235-mL cans Jevity 1.2 Cal, Unflavoured 235-mL cans Jevity 1.2 Cal, Unflavoured 1000-mL RTH containers Jevity 1.2 Cal, Unflavoured 1500-mL RTH containers Jevity 1.5 Cal, Unflavoured 235-mL cans Jevity 1.5 Cal, Unflavoured 1000-mL RTH containers Jevity 1.5 Cal, Unflavoured 1500-mL RTH containers Osmolite 1.2 Cal, Unflavoured 235-mL cans Osmolite 1.2 Cal, Unflavoured 1500-mL RTH containers Suplena, Vanilla 235-mL cans TwoCal HN, Vanilla 235-mL cans PEDIATRIC PediaSure, Vanilla 235-mL cans PediaSure, Chocolate 235-mL cans PediaSure, Strawberry 235-mL cans PediaSure Fibre, Vanilla 235-mL cans PediaSure Plus (with fibre), Vanilla 235-mL cans PediaSure Peptide 1 Cal, Vanilla 237-mL bottles Similac Alimentum, Unflavoured 237-mL cans Similac Alimentum, Unflavoured 400-g cans Similac Neosure, Unflavoured 363-g cans For more information, visit: programs/odb/opdp_nutrition.aspx. RTH = Ready-to-hang 126

127 QUEBEC REIMBURSEMENT LIST The following Abbott nutritional products are listed on the Régie de l'assurance maladie du Québec (RAMQ) List of Medications. RAMQ Code Exception Drug Status Code Description ADULT POLYMERIC FORMULAS Format Glucerna 1.0 Cal, Vanilla 235-mL cans Jevity 1 Cal, Unflavoured 235-mL cans Jevity 1.2 Cal, Unflavoured 235-mL cans Jevity 1.2 Cal, Unflavoured 1000-mL RTH containers Jevity 1.2 Cal, Unflavoured 1500-mL RTH containers Jevity 1.5 Cal, Unflavoured 235-mL cans Jevity 1.5 Cal, Unflavoured 1000-mL RTH containers Jevity 1.5 Cal, Unflavoured 1500-mL RTH containers Nepro, Vanilla 237-mL bottles Nepro, Vanilla 1000-mL RTH containers Osmolite 1.2 Cal, Unflavoured 235-mL cans Osmolite 1.2 Cal, Unflavoured 1500-mL RTH containers Promote, Vanilla 235-mL cans Suplena, Vanilla 235-mL cans TwoCal HN, Vanilla 235-mL cans TwoCal HN, Vanilla 1000-mL RTH containers PEDIATRIC POLYMERIC FORMULAS PediaSure, Vanilla 235-mL cans PediaSure, Chocolate 235-mL cans PediaSure, Strawberry 235-mL cans PediaSure Fibre, Vanilla 235-mL cans PediaSure Plus (with fibre), Vanilla 235-mL cans SEMI-ELEMENTAL VA98 Vital Peptide 1 Cal, Vanilla 220-mL bottles VA98 Vital Peptide 1.5 Cal, Vanilla 220-mL bottles VA98 Vital Peptide 1.5 Cal, Vanilla 1000-mL RTH containers VA98 PediaSure Peptide 1 Cal, Vanilla 237-mL bottles CASEIN HYDROLYSATE-BASED (INFANTS AND CHILDREN) VA105 Similac Alimentum, Unflavoured 237-mL cans POST-DISCHARGE FORMULAS FOR PRETERM INFANTS VA104 Similac Neosure, Unflavoured 363-g cans For more information, visit: pages/medicaments.aspx. RTH = Ready-to-hang 127

128 SASKATCHEWAN REIMBURSEMENT LIST The following Abbott nutritional products are listed by the Saskatchewan Aids to Independent Living (SAIL) Program. Description Format THERAPEUTIC NUTRITIONAL PRODUCTS PROGRAM Glucerna 1.0 Cal, Vanilla Jevity 1.0 Cal, Unflavoured Jevity 1.2 Cal, Unflavoured Jevity 1.2 Cal, Unflavoured Jevity 1.2 Cal, Unflavoured Jevity 1.5 Cal, Unflavoured Jevity 1.5 Cal, Unflavoured Jevity 1.5 Cal, Unflavoured Nepro, Vanilla Nepro, Vanilla Osmolite 1.2 Cal, Unflavoured Osmolite 1.2 Cal, Unflavoured PediaSure Complete Grow & GainTM, All flavours PediaSure, All flavours PediaSure Fibre, Vanilla PediaSure Plus (with fibre), Vanilla PediaSure Peptide 1 Cal, Vanilla Promote, Vanilla RCF Similac Alimentum, Unflavoured Similac Alimentum with DHA, Unflavoured Similac Neosure, Unflavoured Suplena, Vanilla TwoCal HN, Vanilla TwoCal HN, Vanilla Vital Peptide 1 Cal, Vanilla Vital Peptide 1.5 Cal, Vanilla Vital Peptide 1.5 Cal, Vanilla MODULAR SUPPLEMENT eligible if combined with eligible formula LiquiProtein 235-mL cans 235-mL cans 235-mL cans 1000-mL RTH containers 1500-mL RTH containers 235-mL cans 1000-mL RTH containers 1500-mL RTH containers 237-mL bottles 1000-mL RTH containers 235-mL cans 1000-mL RTH containers 235-mL bottles 235-mL cans 235-mL cans 235-mL cans 237-mL bottles 235-mL cans 384-mL cans 237-mL cans 400-g cans 363-g cans 235-mL cans 235-mL cans 1000-mL RTH containers 220-mL bottles 220-mL bottles 1000-mL RTH containers 54-mL bottles CYSTIC FIBROSIS PROGRAM Ensure Regular, All flavours Ensure pudding, All flavours Glucerna 1.0 Cal, Vanilla Glucerna bar, All flavours PediaSure, All flavours PediaSure Fibre, Vanilla PediaSure Plus (with fibre), Vanilla PediaSure Complete Grow & GainTM, All flavours PediaSure Peptide 1 Cal, Vanilla Vital Peptide 1 Cal, Vanilla Vital Peptide 1.5 Cal, Vanilla Vital Peptide 1.5 Cal, Vanilla 235-mL bottles 113-g cups 235-mL cans 40-g bars 235-mL cans 235-mL cans 235-mL cans 235-mL bottles 237-mL bottles 220-mL bottles 220-mL bottles 1000-mL RTH containers For more information, visit: RTH = Ready-to-hang 128

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130 To access an electronic version of this guide, scan the code with your smartphone or visit , option 1 Abbott Laboratories, Limited Printed in Canada DIR/299A08 - September