A Vitamin Formulation Guide To Support Genotype-Directed Eye Vitamin Selection

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Erica Skinner
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1 A Vitamin Formulation Guide To Support Genotype-Directed Eye Vitamin Selection Whether a patient should consume zinc alone, antioxidants alone, or the AREDS formulation (antioxidants plus zinc) to slow the progression of AMD depends upon his or her combined CFH and ARMS2 genotype 1. There is a growing list of Eye Vitamin suppliers who have developed formulations to serve Genotype-Directed Supplementation as per the Vita Risk / Macula Risk PGx genetic testing service. A growing number of eye care professionals are converting to these formulations as their patients present with genetic variations not suitable for zinc or other components of the AREDS formulation. The purpose of this guide is to allow your practice to view the current list of vitamin manufacturers now offering non-zinc formulations, zinc formulations and AREDS formulations. This information has been compiled to assist you in the important decision around optimal vitamin formulation recommendations for your patients indicated by his or her genetic test results. MANUFACTURER COMPANY AND CONTACT INFORMATION DOCTOR S ADVANTAGE info@doctorsadvantage.net DOCTORS OPTIMAL FORMULA Passcode: ArcticDx FORTIFEYE VITAMINS IRX Bethany Masquelier MACULAR HEALTH John Wiley MACUHEALTH garry@macuhealth.com PURE ENCAPSULATIONS Nicole Gross: ngross@purecaps.com VISIVITE EYE FORMULATIONS Nancy Golinko, V.P. Vitamin Science Inc Ext 2 ngolinko@visivite.com VITEYES Physician Relations Specialist: Michelle Customer Service: EYES (3937) ZEAVISION info@zeavision.com AN UP-TO-DATE LIST OF MANUFACTURERS THAT PRODUCE ZINC-FREE AREDS-BASED EYE VITAMINS IS AVAILABLE ON LINE AT: 1 Awh C, Lane A, Hawken S, Zanke B, Kim IK. CFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with Age-related Macular Degeneration. Ophthalmology. 2013;120(11):

2 AREDS 2 AREDS 2 Free Viteyes AREDS 2 Plus Omega-3 AREDS 2 Powder AREDS 2 Advanced Vitamin C 500 mg 500 mg 500 mg 500 mg 500 mg 400 IU 400 IU 400 IU 400 IU 400 IU 25 mg 25 mg 25 mg 25 mg Copper 2 mg 2 mg 2.8 mg 2 mg 2 mg Lutein Zeaxanthin 2 mg 2 mg 2 mg 2 mg 3.5 mg Other 1,000 mg Daily Multivitamin Daily Dosage 2 capsules 2 capsules 3 softgels Cost $52.95 $59.95 $64.95 * 1 scoop, mix with water $64.95 bilberry, grape seed extract & alpha-lipoic acid 2 capsules $59.95 Cost per day $0.59 $0.67 $0.72 $0.72 $0.67 Cost to Doctor Rebate to Dr on patient order $34.95 $39.95 $45.95 $39.95 Available upon request; Contact: Michelle $39.95 Company Contact Customer Service 24/ EYES (3937) Physician Relations Specialist: Michelle *Save an additional 10% on autodelivery (as low as $0.53 per day) Macular Shield AREDS 2 plus Complete Multivitamin Doctor s Advantage Macular Shield AREDS 2 w Macular Shield AREDS 2 w/o Vitamin C 500 mg 500 mg 500 mg 400 IU 400 IU 400 IU 80 mg 80 mg 0 Copper 2 mg 2 mg 0 Lutein Zeaxanthin 2 mg 2 mg 2 mg Vitamin D Thiamine Riboflavin Niacin Vitamin B6 Folic Acid Vitamin B12 Biotin Pantothenic Acid Calcium Chromium Citrus Bioflavonoids Bilberry Coenzyme Q-10 Daily Dosage 800 IU 1.5 mg 1.7 mg 20 mg 400 mcg 50 mcg 30 mcg 100 mg 150 mcg 80 mg 400 mcg 2 twice daily Cost $32.95 $24.95 $24.95 Cost per day $1.09 $0.83 $0.83 Cost to Doctor $22.95 $18.95 $18.95 Rebate to Dr on patient order $10.00 $6.00 Company Contact info@doctorsadvantage.net

3 Macular Health - Genetic Formulas AREDS II Antioxidant Only Only (80mg) Vitamin C 500 mg 500 mg 400 IU 400 IU Low Dose Only (25mg) 25 mg 80 mg 25 mg Copper 2 mg 2 mg 2 mg Lutein Zeaxanthin 2 mg 2 mg Other Daily Doseage 2 per day 2 per day 1 per day 1 per day Cost $21.95 $20.95 $14.95 $14.95 Cost per day $0.73 $0.70 $0.50 $0.50 Cost to Doctor $15.00 $14.00 $10.00 $10.00 Rebate to Dr on patient order Company Contact AMD Labs, LLC Depends on option that doctor selects. Minimum is $5 per patient per month but can easily be more Component John Wiley irx Antioxidants Antioxidants with LZ component AREDS Per Day Per Day Per Day Per Day Per Day Vitamin C (as ascorbic acid) 500 mg 1000 mg 500 mg (dl-alpha-tocopheryl acetate) 400 IU 400 IU 400 IU (from zinc oxide) 80 mg 80 mg 80 mg Copper (from copper oxide) 2 mg 2 mg 2 mg Lutein (from marigold extract) Zeaxanthin 2 mg 2 mg 2 mg 2 mg Daily Doseage 2 Tablets 4 Tablets 4 Tablets 2 Tablets Suggested Minimum Cost $12/90 day $45/90 day $45/90 day $30/90 day Cost per day to Patient $0.13 $0.50 $0.50 $0.33 Cost to Doctor/Providers $5.95/90 day $25.90/90 day $27.03/90 day Rebate to Dr on patient order Available on Request Company Contact Bethany Masquelier VisiVite Eye Formulations VisiVite AREDS2 Silver VisiVite AREDS2 White Vitamin C 500 mg 500 mg 400 iu 400 iu 40 mg Copper 2 mg 2 mg Lutein Zeaxanthin 2 mg 2 mg Daily Dosage 2 vegetarian capsules/day Cost $23.95 $23.95 Cost per day $0.80 $0.80 Cost to Doctor $14.00 $14.00 Rebate to Doctor on patient order Company Contact 20% Nancy Golinko, V.P., Vitamin Science, Inc Ext 2 ngolinko@visivite.com $14.82/90 day Brand/Content Doctors Optimal Formula Whole Body AREDS2 with Whole Body AREDS2 w/o Vitamin C 500 mg 500 mg 400 IU 400 IU 25 mg Copper 2 mg 2 mg Lutein Zeaxanthin 2 mg 2 mg Mesozeaxanthin 11 mg 11 mg Vitamin D COQ10 40 mg 40 mg Phytosterols 250 mg 250 mg Acetl-L Carnitine 300 mg 300 mg Calcium Carbonate 240 mg 240 mg Thiamin 1.5 mg 1.5 mg Riboflavin 1.71 mg 1.71 mg Niacin 20 mg 20 mg B-6 3 mg 3 mg Folic Acid 0.4 mg 0.4 mg B mcg 30 mcg Biotin 0.1 mg 0.1 mg Pantothenic Acid Magnesium Oxide 30 mg 40 mg Manganese Gluconate 2.4 mg 2.4 mg Potassium Gluconate 75 mg 75 mg Acai Berry 100 mg 150 mg Omega 3 Powder 250 mg 250 mg Transresveratrol Granular 75 mg 100 mg Selenium 200 mcg 200 mcg Lycopene 4 mg 4 mg Eyebright Bilberry 40 mg 50 mg Daily Dose Cost 3 capsules/day $39.95/90 capsules Cost/day $1.25 $1.25 Doctors Wholesale 50% 50% Doctors Referral 25% 25% Contact com/ Passcode: ArcticDx

4 ZeaVision -Free Formulas ZeaVision Formulas with Brand/Product EyePromise AREDS2 Plus - Free EyePromise Restore - Free EyePromise AREDS2 Plus EyePromise Restore Vitamin A Beta Carotene 5,000 IU Vitamin C 500 mg 120 mg 500 mg 120 mg 400 IU 60 IU 400 IU 60 IU mg 15 mg Copper 0 0 2mg 0 Lutein 4 mg 4 mg Zeaxanthin 8 mg 8 mg Mesozeaxanthin Vitamin D 2,000 IU 1,000 IU 2,000 IU 1,000 IU Vitamin K1 Vitamin B1 Vitamin B2 Vitamin B3 Vitamin B6 Folic Acid Vitamin B12 Biotin Iron Pantothenic Acid Iodine Magnesium 25 mcg 1.5 mg 1.7 mg 20 mg 2 mg 400 mcg 6 mcg 30 mcg 18 mg 150 mcg Fish Oil 250 mg 250 mg 250 mg 250 mg EPA 100 mg 100 mg 100 mg 100 mg DHA 75 mg 75 mg 75 mg 75 mg Mixed Tocopherols 20 mg 6 mg 20 mg 6 mg Alpha Lipoic Acid 20 mg Selenium Chronium Molybdenum Boron Vanadium Nickel Tin Lycopene Eyebright Bilberry 100 mg 20 mcg 5 mcg 75 mcg 150 mcg 10 mcg 120 mcg Daily Dosage 2 softgels/day 1-2 softgels/day 1 tab & 1 softgel/day 1-2 softgels/day Cost / 30 doses TBD* $ $33.95* TBD* $ $33.95* Cost/day TBD*.56 - $1.13/day* TBD*.56 - $1.13/day* Doctors Wholesale Yes Yes Yes Yes Doctors Referral Yes Yes Yes Yes Contact info@zeavision.com info@zeavision.com 10 mcg * With Dr. Referral * With Dr. Referral * With Dr. Referral Contains Centrum-Silver Equivalent * With Dr. Referral

5 Fortifeye Vitamins Brand/Content Once Daily Complete Plus Complete Macular Defense Free Macular Defense Focus Super Omega Vitamin C 167 mg 334 mg 500 mg 500 mg 15 IU mixed tocopherols and tocotrienols 30 IU mixed tocopherols and tocotrienols 45 IU mixed tocopherols and tocotrienols 45 IU mixed tocopherols and tocotrienols 13 mg 26 mg 40 mg 0 Copper Lutein 6.67 mg mg 20 mg 20 mg 6 mg Zeaxanthin 1.5 mg 3 mg 4.5 mg 4.5 mg 400 mcg Mesozeaxanthin 1.5 mg zeaxanthin isomers 3.5 mg zeaxanthin isomers 4.5 mg zeaxanthin isomers 4.5 mg zeaxanthin isomers Omega 3 EPA none 430 mg TG form 430 mg TG form none EPA 860 Omega 3 DHA none 290 mg TG form 290 mg TG form none DHA 580 Vitamin D3 750 IU 1500 IU 2250 IU 2250 IU Thiamin 3.33 mg 6.67 mg Riboflavin 2.67 mg 5.33 mg 8 mg 8 mg Niacin 8 mg 16 mg 24 mg 24 mg Astaxanthin none none none none 6 mg Vitamin B6 6 mg 12 mg 18 mg 18 mg Folate 100 mcg 200 mcg 300 mcg 300 mcg Vitamin B mcg 250 mcg 375 mcg 375 mcg Biotin mcg mcg 500 mcg 500 mcg Pantothenic mg mg 50 mg 50 mg Calcium 40 mg 80 mg 120 mg 120 mg Phosphorous 22.5 mg 45 mg 67.5 mg 67.5 mg Magnesium mg 33 mg 50 mg 50 mg Selenium 33.5 mcg 67 mcg 100 mcg 100 mcg Manganese 0.67 mg 1.34 mg 2 mg 2 mg Chromium 50 mcg 100 mcg 150 mcg 150 mcg Coq mg 40 mg 60 mg 60 mg Alpha lipoic acid 66.5 mg 133 mg 200 mg 200 mg Boron 66.5 mcg 133 mcg 200 mcg 200 mcg Bromelain 6.5 mg 13 mg 20 mg 20 mg Acetyl 1 Carnatine 30 mg 60 mg 90 mg 90 mg Hesperidin 3.33 mg 6.66 mg NAC 50 mg 100 mg 150 mg 150 mg Quercetin 6.5 mg 13 mg 20 mg 20 mg Taurine 75 mg 150 mg 225 mg 225 mg Turmeric 20 mg 30 mg 30 mg Vanadium 3 mcg 6 mcg 9 mcg 9 mcg Lycopene 1 mg 2 mg 3 mg 3 mg Tocotrienols 5 mg 15 mg 15 mg Reservatrol mg mg 40 mg 40 mg Green Tea 100 mg 200 mg 300 mg 300 mg Goji Berry 75 mg 150 mg 225 mg 225 mg Kale 25 mg 50 mg 75 mg 75 mg Blueberry 6.6 mg mg 20 mg 20 mg Grape Seed 5 mg 15 mg 15 mg Acai 5mg 15 mg 15 mg Cocoa 3.3 mg 6.7 mg Pomegranate 3.33 mg 6.67 mg Cinnamon 3.33 mg 6.7 mg Spinach 20 mg 40 mg 60 mg 60 mg Daily Dose One tablet daily Daily blister pack: 2 tablets/ 1 gel capsule Daily blister pack: 3 tablets / 1 gel capsule Daily blister pack: 3 tablets Cost/30 days $25.00 $50.00 $70.00 $55.00 $25.00 $25.00 Cost/day $0.83 $1.67 $2.33 $1.83 $0.83 $0.83 Doctors Wholesale $13.00 $29.00 $39.00 $27.00 $13.00 $14 Contact

6 MacuHealth Pure Encapsulations Brand/Content AREDS2 Formulation MACUHEALTH MAC-AREDS MAC-AREDS NO EyeProtect Basics EyeProtect Basics w/o Only Vitamin A Beta Carotene Vitamin C Vitamin C 500 mg 400 IU 80 mg / 25 mg 500 mg 500 mg 500 mg 500 mg 400 IU 400 IU 400 IU 400 IU 25 mg 25 mg Copper Copper 2 mg 2 mg 2 mg 2 mg Lutein Lutein Zeaxanthin Mesozeaxanthin Vitamin D Fish Oil EPA DHA Mixed Tocopherols Alpha Lipoic Acid Selenium Lycopene Eyebright Bilberry Daily Dosage Cost Zeaxanthin 2mg 2mg 2 mg 2 mg 10mg 1 softgel per day $75.00/90 capsules 1 tablet per day Daily dose = 2 vegetarian capsules / day $12.00/90 tablets $12.00/90 tablets $20.10 /60 capsules $19.90 /60 capsules (Picolinate) 30 mg 1-2 tabs/day $11.50 /60 tablets Cost/day $0.83 $0.13 $0.13 $0.67 $0.66 $0.09 / day Doctors Wholesale $38.00/90 softgels $8.00/90 tablets $10.05 $9.95 Doctors Referral $20 to doctor N/A N/A Contact garry@macuhealth.com % of SRP ( Nicole Gross ngross@purecaps.com $5.75 To learn more about Genotype-Directed Eye Vitamin Therapy contact Customer Service: 1 (866) customerservice@macularisk.com *All information herein has been provided to Arctic by the vitamin manufacturers referenced. VR

Supplement Facts Serving Size 1 Packet

Supplement Facts Serving Size 1 Packet Propax with NT Factor Supplement Facts Box DIRECTIONS: As a dietary supplement take 2 or 3 packets over the course of the day. The 4 multitablets may be taken with or without food and should be consumed