A study of attitude to uncleanness on daily life and eating behavior in female college students and female high school students

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1 [ 総説 ] A study of attitude to uncleanness on daily life and eating behavior in female college students and female high school students Fumio Namba Depertment of Research Development, Fujicco Co. Ltd, - -, Minatojimanakamachi, Chuo-ku, Kobe-shi, Hyogo, - A part of the bone is always dissolved and absorbed by osteoclast bone resorption. And osteoblasts form a new bone osteoplasty. When this balance collapses, it leads to the disease called the bone metabolism abnormality symptom, and the most common example is osteoporosis. In male and female, the bone mass reaches maximum in mid-3 years old and decreases gradually with aging afterward. It is revealed that estrogen greatly participates in maintaining a bone mass. Because in the women in particular, the sudden decrease in bone mass happens for postmenopausal 5-1 years, and there is knowledge such as there being fewer losses of the bone mass than the woman who is irregular in the women who are stable in their menstrual cycle. It is known that the soy isoflavone has weak estrogen-like activity. The effects of isoflavones on bone are confirmed not only in vitro examination but also in animal experiment and a clinical trial. It is thought that these effects act by mechanism same as bone resorption restraint action of estrogen. Black soybean, a type of soybean with a black seed coat, has been widely used as a nutritionally rich food in Asia. Black soybean has been utilized as a traditional Chinese medicine for preventing of cardiovascular diseases, improving aging liver and kidney functions, and for accelerating diuretic action. Black soybean seed coat contains numerous bioactive compounds including proanthocyanidins and anthocyanins. These compounds have activity as radical scavengers, anti-diabetic and anti-inflammatory agents, and for improving the fluidity of blood. These multiple activities may have some effects on endothelial function. 1. はじめに

2 Vol. No. in vitro JPHC Study 2. 日本人の大豆イソフラボン摂取量 75 mg を目標に mg mg mg JPHC Study mg mg 表 1 骨密度および更年期障害に対する大豆イソフラボンのヒト無作為比較試験 Nahas et al. mg Chen et al. mg Ca Wu et al. mg Han et al. mg Kuppeman Upmalis et al. mg 1 年度別 2 年齢階級別 ( 平成 19 年度 ) 摂取量 (mg/ 日 ) 摂取量 (mg/ 日 ) 平成 ( 年度 ) ( 歳 ) 図 1 日本人の大豆イソフラボン摂取量 ( 全国平均 )

3 mg/ mg/ mg/ 3. 大豆イソフラボンと運動の併用効果 km/h mg/ DXA mg mg/ 4. 大豆イソフラボンと他素材の併用効果 ( 1 ) イソフラボンの吸収代謝に対する効果 Ohta OVX ( 2 ) 骨粗鬆症に対する効果 PGE TNF α PUFA Ca ATPase Ca OVX / ( 3 ) メタボリックシンドロームに対する効果 PPAR AMPK CTP Sirt PPAR L ( 4 ) カルシトニン遺伝子関連ペプチド (CGRP) を介した効果 CGRP CGRP IGF CGRP CGRP IGF 5. 黒大豆ポリフェノールの機能性

4 Vol. No. NO NO enos NO NO cgmp NO2 - /NO3 - μ mol/mmol creatinine 摂取前 p=.11 摂取後 平均 図 2 黒大豆ポリフェノール摂取による尿中 NO 代謝産物の変化 mg/ NO mg NO NO in vitro DPPH SOD -galactosidase SA galsa gal T L 低温負荷直後 1 分後 4 分前にデキストリン摂取 4 分前にクロノケア摂取 図 3 黒大豆ポリフェノール摂取による低温負荷後の体表面温度変化 mg

5 NADPH oxidase subunit mrna in vivo mg/kg/ TBARS 6. おわりに 文献 Iwasaki M., et al.: J Clin Oncol., 26, - Akhter M., et al.: Cancer Epidemiol Biomarkers Prev., 17, - Kurahashi N., et al.: J Clin Oncol., 26, - Shimazu T., et al.: Am J Clin Nutr., 91, - Nanri A., et al.: J Nutr., 14, - Nahas E. A. P., et al.: Maturitas., 58, - Chen Y. M., et al.: Menopause., 11, - Wu J., et al.: J Bone Miner Res., 21, - Han K. K., et al.: Obest Gynecol., 99, - Upmalis D. H., et al.: Menopause., 7, - Ohta A., et al.: J Nutr., 132, - WO / Ward W. E., et al.: Mol Nutr Food Res., 51, - Watkins B. A., et al.: J Nutr Biochem., 16, - Park H. J., et al.: J Med Food., 11, - Shin E. S., et al.: Eur J Nutr., 45, - Yang J-Y., et al.: J Med Food., 9, - Shimozawa N., et al.: Am J Physiol Gastrointest Liver Physiol., 292, G - Harada N., et al.: Growth Horm IGF Res., 17, - Harada N., et al.: Biosci. Biotechnol. Biochem., 73, - Ting R.17 CLINICIAN 456 Furukawa S, et al.: J Clin Invest., 114,- p. Kanamoto Y., et al.: J Agric Food Chem., 59, - FRAGRANCE JOURNAL 9 p. 54