Mycotoxin Petfood Binder

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1 Welcome To: Ultrateck Laboratories Inc. Bio-Logics Aflatrol Mycotoxin Petfood Binder What is Aflatrol? Aflatrol is presently showing a high potential for aflatoxin mycotoxin binding in animal feeds and field studies indicate other benefits from the effects of this product. It is generally recognized by petfood manufacturers that mycotoxin contamination is a source of increased problems in their industry. Ingredients that are at risk of becoming contaminated are wheat and wheat products, corn and corn products, soybean meal and hulls, barley and oats. Mycotoxins can develop prior to harvest where their concentration depends on weather and natural conditions, including moisture, temperature, ph and stresses such as drought and associated growth of other fungi and microbes. Grains and feeds can also be contaminated with mycotoxins between harvesting and drying, as well as during storage. Once produced, these toxins cannot be readily extracted from contaminated feed. The major mycotoxins with potential for contamination of pet foods are aflatoxins,vomitoxin, zearalenone, fumonisins, and ochratoxin A. Three genera of fungi, Aspergillus, Penicillium, and Fusarium (Gibberella), are the most frequently implicated causes of mycotoxin contamination. Aflatoxins are one of the most potent naturally-occurring carcinogens known to man and have been associated with a variety of health problems in both animals and

2 man. All species appear to be susceptible to this toxin, although susceptibility varies from species to species. The primary target organ for aflatoxins is the liver with liver disease resulting from dogs ingesting aflatoxin-contaminated dog food. Vomitoxin, known chemically as deoxynivalenol (DON), affects weight gain and appetite in pigs, with 10 ppm resulting in loss of appetite, vomiting and weight loss. It is also known to adversely affect the immune system, although at what levels this would start to occur remains unknown. Little is known about its toxicity in pets. It is known that dogs are susceptible to relatively low levels of vomitoxin and exhibit health problems similar to that seen in swine. Cats, as well as cattle, poultry, and humans, can also be affected. Zearalenone has been reported to cause clinical signs in poultry, swine and man, but not in dogs or cats. Zearalenone has a chemical structure similar to that of estrogen and causes hyperestrogenism in both laboratory animals and agricultural livestock. Its effects are mainly on the reproductive system. In pigs, it can cause serious reproductive problems, including failure to show heats and reduced sex drive in boars. It can also affect foetal development and the viability of neonates. The intensity of symptoms is dependent on the amount of toxin consumed. Fumonisins interfere with cell membrane metabolism and the signs of toxicity vary with species. The only studies conducted to demonstrate the effects of fuminosins in pet species has been in rabbits. Ochratoxin A is a nephrotoxin (i.e. toxic to the kidneys) and is also teratogenic (i.e. causes fetal malformation during the first three months of pregnancy) in all species tested. It also impairs the immune system and is a suspected carcinogen. Aflatrol contains natural highly adsorbent montmorillonite layered silicate mineral clays and humified vegetable carbons with a honey comb pores structure, containing a myriad of substances found in several naturally occurring deposits of minerals produced by metamorphic and sedimentary activities of the earth's geology millions of years ago. Aflatrol also contains MOS mannan oligosaccharides glucomannans and fructose oligosaccharides, dried lactobacillus acidophilus whey fermentation solubles combined with specific botanical herbal extracts known for their nutraceutical effects in animal feeds. The ingredients contained in Aflatrol are not affected by high extrusion temperatures or pelleting The ingredients contain aggregate forming molecules that act as chelating agents which can mobilize nutrients across various tissue membranes, thereby increasing the bio-availability of nutrients, especially minerals within the animals feed. These nutrients are often complexed (tiedtip) by such agents phytates and phosphates etc. In addition to the benefits associated with the physical dynamics of UT-Alphatrol Premix, it also provides a nutrient-dense source of rare, naturally chelated macro and micro nutrients which are no longer readily supplied by various feed-stuffs due to soil depletion and processing methods.

3 Alphatol is a source of biosis factors, pathogen inhibition resulting from the addition lactobacillus acidophilus whey fermentation solubles rich in lactic acid, lactose, amino acids and other undefined nutrient factors (U.N.F's.) created during the fermentation process. Aflatrol Research Test Results & Registrations Aflatrol Test Results Taiwan Registration No (Mycotoxin Binder) (Binding Properties at 300g/ton/inclusion rate/% of reduction) Aflatoxins % T-2 Toxins % Deoxynivalenol % Vomitoxin % Citrin % Rubratoxin % Griseofulvin % Zeralenone (F-2) % The above government lab test was conducted on corn and soya feed grains. Aflatrol is registered in Taiwan and many parts of Asia, Latin America, North America under private label and or / license agreements. Most of the compiled research on this product which we manufacture was compiled by our distributors. General Indications: Aflatrol potential benefits when added to pet foods: (1) Binding of numerous mycotoxins (2) Helps reduce blood urea nitrogen B.U.N. (3) Provides naturally chelated minerals (4) Normalize acid alkaline balance in gut (5) Stimulates production of digestive enzymes (6) Stimulates the growth and proliferation of beneficial intestinal flora (7) Improves feed conversion less fecal output with lower manure odors Low economical inclusion rates (300g to 2 Kg/metric/ton or - 8 oz to 4 pounds) Compatible with high temperature processing via extrusion/pelleting Aflatrol - 25 Kg Fiber Kegs or feed mill bulk 1 ton/tote/bags General: Dry kibble type Pet foods 2 kg per/metric/ton Wet canned type Petfoods 2 kg per/metric/ton Healthy dog and cat Treats 3 to 4 kg per/metric/ton Compatible with high temperature processing via baking/extrusion/pelleting

4 Ultra Mannan Oligosaccharide Blocking of colonization pathogens Concentrated MOS Yeast Extract Ultra Mannan Oligosaccharide: a naturally derived extract from the cell wall of Saccharomyces cerevisiae, is an animal feed ingredient and fermentation additive, with a mannose content of approximately 20% wt/wt basis. Typical usage: Product Typical Specifications: Physical form and color: Non-Hydroscopic..Light brown powder Particle size (through a 20 mesh screen) % Protein % Ash % max. Moisture...5.0% max. Lipid...5.0% max. Total plate count /g max. Yeast and molds...100/g max. Coliforms...Negative Salmonella...Negative(25g) Typical usage levels range from 1 to 3 kg/ton/feed. Benefits and Advantages: Blocking of colonization pathogens One mode of action for mannan-based oligosaccharides involves interference with colonization of intestinal pathogens. Cell surface carbohydrates are primarily responsible for cell recognition. At the simplest level is the role of carbohydrates in blood types which are differentiated by cell coat sugars. Bacteria have lectins (proteins or glycoproteins) on the cell surface that recognize specific sugars and allow the cell to attach to that sugar. These sugars can be found on the epithelial cell surface. Binding of Salmonella, Escherichia coli and Vibrio cholera has been shown to be mediated by a mannosespecific lectin-like substance on the bacterial cell surface.

5 Storage: Store under cool and dry conditions. Containers should be kept sealed and dry. Shelf life: Stable for more than 12 months when stored under recommended conditions. General: Dry kibble type pet foods 2 kg per/metric/ton Wet canned type pet foods 2 kg per/metric/ton Healthy dog and cat treats 3 kg per/metric/ton Compatible with high temperature processing via baking/extrusion/pelleting Packaging: 55 pound lined bags - (25 kg metric) International Exportation Division Laboratoires Ultrateck Laboratories Inc. Chateauguay Québec J6J 4Z2