NM SACHINDRA JSPS Post-Doctoral Research Fellow. Prof. K MIYASHITA. Faculty of Fisheries Hokkaido University, Hakodate

Size: px

Start display at page:

Download "NM SACHINDRA JSPS Post-Doctoral Research Fellow. Prof. K MIYASHITA. Faculty of Fisheries Hokkaido University, Hakodate"

Myra Henry
5 years ago
Views:

1 NM SACHINDRA JSPS Post-Doctoral Research Fellow Prof. K MIYASHITA Faculty of Fisheries Hokkaido University, Hakodate

2 Mysore India Karnataka

3 Working as: Scientist Central Food Technological Research Institute (CFTRI), Mysore, India CFTRI

5 CAROTENOIDS HEALTH WITH COLORS Sachindra NM JSPS Post-Doctoral Research Fellow Faculty of Fisheries Hokkaido University, Hakodate

6 WHAT ARE CAROTENOIDS? Carotenoids are a group of pigments (Colors) present in nature Yellow, red, orange pigments

7 More than 600 carotenoids in nature Present in Flowers, Fruits and vegetables, microorganism, seafoods, animals

8 FLOWERS

9 FRUITS AND VEGETABLES

10 SEA FOODS AND ANIMALS

11 MICROORGANISMS

12 Plants can synthesize Carotenoids Gernanylgernanyl-PP Phytoene + 2 PP Carotenoids Animals depend on diet for carotenoids Converts one form to another

13 ROLE OF CAROTENOIDS In plants carotenoids are essential in Photosynthesis Dietary sources of vitamin A (retinol) and Antioxidants in Humans and Animals A

14 SOME ORANGE

15 Some Orange Mandarin Orange, Carrot, Mango, Sweet Potato Beta Carotene

16 SOME ORANGE FEW REDS

17 Few Reds Tomato, Water melon, Cherries, Strawberry Lycopene

18 SOME ORANGE FEW REDS LITTLE GREENS

19 Little Greens Green Leafy vegetables Lutein Zeaxanthin Neoxanthin

20 SOME ORANGE FEW REDS LITTLE GREENS SOME YELLOW

21 Some Yellow Corn, Pineapple, Squash, Zeaxanthin

22 SOME ORANGE FEW REDS LITTLE GREENS SOME YELLOW SEAWEEDS

23 Seaweeds Fucoxanthin

24 SOME ORANGE FEW REDS LITTLE GREENS SOME YELLOW SEAWEEDS Green? SOME SEAFOODS

25 SOME SEAFOODS Shrimp, Crab, Lobster, Salmon Astaxanthin

26 CAROTENOIDS AND HEALTH Vitamin A activity A Antioxidant activity Anticancer activity Antiobesity effect

27 Vitamin A is essential for A Vision ( Rhodopsin is the Visual pigment needed to see in dim light In the Eye- Rhodopsin + Light Retinal + Opsin Alteration in sodium ion channels and electrical signal to brain.

28 Some retinal is lost during the process Retinol (Vit. A) obtained from blood is converted to retinal in eye A

29 Vitamin A FUNCTIONS OF CAROTENOIDS Some carotenoids possess Pro-Vitamin A activity -carotene -carotene -cryptoxanthin Are converted to Vitamin A in liver -carotene OH OH Retinol (Vit. A)

30 Carotenoids as Antioxidants Oxidants Cell Light Heat Pollutants Stress Antioxidant Electron Stable molecule Free radical Stable molecule Electron

31 IN THE BODY Protein, Fat in the cells Oxidation Oxidation products AND Free radicals Free radicals IN THE FOOD SYSTEM Protein, Fat in the Food Oxidation Oxidation products AND Free radicals DNA DAMAGE DISEASE

32 IN THE BODY Protein, Fat in the cells Free radicals Carotenoids IN THE FOOD SYSTEM Protein, Fat in the Food HEALTHY BODY INTACT DNA

33 Oxidants activate stable molecules in cells to loose electron Free radical formation Lack one electron Free radicals try to steal electron from cell components cell damage

34 Free radicals oxidize cellular components- Protein, Lipid Formation of more radicals ( Damage to DNA DNA

35 Free radicals oxidizes Food components Oxidized food components bad for health Antioxidants stabilizes free radicals by donating electron

36 CAROTENOIDS are rich in electrons stabilizes free radical by donating an electron

37 protect the cells from damaging effects of free radicals protect foods from oxidation

38 ANTI-CANCER ACTIVITY OF CAROTENOIDS Cancer Uncontrolled growth of cells in the body Damaged normal cells are eliminated by apoptosis Normal Cell apoptosis apoptosis:programmed cell death. Controlled by genes that cause a cell to die at a specific time, e.g., when DNA is damaged.

39 Cancer cell avoid apoptosis, mulitiply in an unregulated manner Cancer drugs induce apoptosis in cancer cells Cancer drugs also damages some normal cells

40 ANTI-CANCER ACTIVITY OF CAROTENOIDS Cancer Cell Normal Cell Apoptosis Carotenoid No Effect Dead Cell Cancer Drugs Normal Cell Some Effect Cell Damage

41 Marine Carotenoids Wakame Solvent extract Fucoxanthin Enzymatic conversion Fucoxanthinol Halocynthiaxanthin

42 ANTI-CANCER ACTIVITY - Apoptosis Effect Control Fucoxanthin

Cardiovascular Disease OBESITY Accumulation of fat around the

43 ANTIOBESITY EFFECT OF CAROTENOIDS Adipocytokines FAT FAT FAT FAT FAT FAT FAT FAT Various diseases Diabetes Hypertension Cardiovascular Disease OBESITY Accumulation of fat around the internal organs A major risk factor causing many kinds of diseases

44 Energy dissipation Brown adipose tissue UCP1 Human Adipose tissue Heat White adipose tissue Adipocytokines Various diseases Mitochondrial uncoupling protein 1 (UCP1) is usually expressed only in brown adipose tissue (BAT) A key molecule for metabolic thermogenesis to avoid excess fat accumulation.

45 White adipose tissue Synthetic compounds? Natural compouds UCP1 UCP1 expression Fat is oxidized by UCP1 White adipose tissue (WAT) don t have UCP1 protein. Some synthetic compounds induce UCP1 protein in WAT Induction of UCP1 protein expression by natural compounds? Little BAT in adult humans. UCP1 expression in tissues other than BAT is expected to reduce abdominal fat

46 FUCOXANTHIN ANTI OBESITY EFFECT Feeding seaweed lipids containing fucoxanthin Rat and Mice Reduction of abdominal WAT weights Signals of UCP1 protein detected in WAT of mice fed with fucoxanthin containing lipids and fucoxanthin Little expression of UCP1 in WAT of mice fed control diet.

47 SHRIMP WASTE AS A SOURCE OF CAROTENOID Processing Whole shrimp Meat Head + Body Shell Solvent Extraction Pigments

48 Color from Shrimp waste Good source of astaxanthin Improves the color and flavor of fish sausage

49 As a source of Pigment for Ornamental Fish

50 What`s in TODAY`S DINNER Carotenoid??? Zeaxanthin Lycopene? Neoxanthin?

51 JSPS Sacred Heart High School, Sapporo Administration Teachers Students Prof. K Miyashita My Friends at Hakodate Contact me anytime at: sachiprathi@yahoo.com

Color Your Customers Healthy With Carotenoids

Color Your Customers Healthy With Carotenoids By Yousry Naguib, PhD Fruits and vegetables get their vibrant colors from carotenoids, a class of closely related chemicals. Approximately 600 carotenoids