SAFETY DATA SHEET Version 1.0 Revision date 13/01/ IDENTIFICATION OF SUBSTANCE AND COMPANY DETAILS. 1.1 Product identifier

Transcription

1 1. IDENTIFICATION OF SUBSTANCE AND COMPANY DETAILS SAFETY DATA SHEET Version 1.0 Revision date 13/01/ Product identifier Product name : RUBIC Additive Screen Product number : MD1-97 EC No. : See section 3 REACH registration number : See section 3 CAS No. : See section Relevant identified uses of the substance or mixutre and uses advised against Identified uses Uses advised against : Research and Development : Not for drug, household or uses other than those identified 1.3 Details of the supplier of the Safety Datasheet Supplier : Molecular Dimensions Limited Address : Unit 6 Goodwin Business Park Willie Snaith Road Newmarket Suffolk CB8 7SQ United Kingdom Telephone : +44 (0) Fax : +44 (0) address : enquiries@moleculardimensions.com 1.4 Emergency telephone number Emergency phone number : HAZARDS IDENTIFICATION 2.1 Classification of substance or mixure Classification according to Regulation (EC) No. 1272/2008 [CLP] H315 H225 H302 H301 H319 H316 H290 H303 H272 H301+H311+H331 H311 H317 H313 H318 H335 H370 H331 H334 H360D H333 H400 H410 H341 H412 EUH032 H336 H350i EUH066 H360F H372 Causes skin irritation Highly flammable liquid & vapour Harmful if swallowed Toxic if swallowed Causes serious eye irritation Causes mild skin irritation May be corrosive to metals May be harmful if swallowed Causes severe skin burns and eye damage May intensify fire; oxidizer Toxic if swallowed, in contact with skin or inhaled Toxic in contact with skin May cause an allergic skin reaction May be harmful in contact with skin Causes serious eye damage May cause respiratory irritation Causes damage to organs Toxic if inhaled May cause allergy or asthma symptoms or breathing difficulties if inhaled May damage the unborn child May be harmful if inhaled Very toxic to aquatic life Very toxic to aquatic life with long-lasting effects Suspected of causing genetic defects Harmful to aquatic life with long-lasting effects Contact with acids liberates very toxic gas May cause drowsiness or dizziness May cause cancer by inhalation Repeated exposure may cause skin dryness or cracking May damage fertility Causes damage to organs through prolonged or repeated exposure 2.2 Label elements Labelling according to Regulation (EC) No. 1277/2008 [CLP] 2.3 Other hazards Precautionary codes P261 P305+P351+P338 P280 P201 P273 P301+P310 P220 P302+P352 P310 P311 P308+P313 P501 Avoid breathing dust/fume/gas/mist/vapours/spray IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do continue rinsing Wear protective gloves/protective clothing/eye protection/face protection Obtain special instructions before use Avoid release to the environment IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician Keep/Store away from clothing/combustible materials IF ON SKIN: Wash with soap and water Immediately call a POISON CENTER or doctor/physician Call a POISON CENTER or doctor/physician IF exposed or concerned: Get medical advice/attention Dispose of contents/container according to instructions on SDS

2 3. COMPOSITION/INFORMATION ON INGREDIENTS 3.2 Mixtures Chemical EC No. REACH No. CAS No. Concentration H-code(s) P-code(s) 3-(1-Pyridino)-1-propanesulfonate Adenosine 3,5 -cyclic monophosphate sodium salt monohydrate Adenosine 5 -[γ-thio]triphosphate tetralithium salt H315 H319 H335 P261 P305+P351+P338 Adenosine 5'triphosphate disodium salt hydrate H225 H301+H311+H331 H370H319H336 EUH066 Ammonium acetate Ammonium chloride H302 H319 P305+P351+P338 Ammonium fluoride H301 H311 H331 P261 P280 P301+P310 Ammonium sulfate Betaine hydrochloride H319 P305+P351+P338 Biotin Calcium acetate hydrate H315 H319 H335 P261 P305+P351+P338 Calcium chloride dihydrate H319 P305+P351+P338 CHAPS H316 P280 CHAPSO Cobalt(II) chloride hexahydrate H302 H317 H334H341H350i H360F H410 P201 P261 P273 P280 P308+P313 P501 Coenzyme A sodium salt hydrate D-(+)-Galactose D-(+)-Glucose D-(+)-Maltose monohydrate D-(+)-Mannose D-(+)-Xylose Deoxyribonucleic acid, from herring sperm Dimethyl sulfoxide DL-Dithiothreitol H302 H315 H319 H335 P261 P305+P351+P338 Ethylene glycol H302 Ethylene glycol-bis(2-aminoethylether)-n,n,n,n -tetraacetic acid Ethylenediaminetetraacetic acid H319 P305+P351+P338 Fos-Choline Glycerol Glycine Gly-Gly-Gly Guanidine hydrochloride H302 H315 H319 P305+P351+P338 Guanosine 3,5 -cyclic monophosphate sodium salt Guanosine 5'-[ƴ-thio]triphosphate tetralithium salt H315 H319 H335 P261 P305+P351+P338 Guanosine 5 -triphosphate sodium salt hydrate Imidazole XXXX H302 H360D P201 P280 P305+P351+P338 Iron(III) chloride hexahydrate H290 H302 H315H318 P280 P305+P351+P338 L-(-)-Fucose L-Arginine L-Glutamic acid monosodium salt hydrate Lithium chloride H302 H315 H319H335 P261 P305+P351+P338 L-Proline Magnesium chloride hexahydrate Magnesium sulfate heptahydrate Manganese(II) chloride tetrahydrate H302 N-Acetyl-D-glucosamine n-decyl-β-d-maltopyranoside n-dodecyl-β-d-maltopyranoside H303 H313 H333 P261 P280 P302+P352 NDSB Nickel(II) chloride hexahydrate H301 H315 H317H334H341 H350i H360D H372 H410 H331 P201 P261 P273 P280 P301+P310 P311 Nicotinic acid H319 P305+P351+P338 n-octyl-β-d-glycopyranoside Oxaloacetic acid Poly(ethylene glycol) Poly(ethylene glycol) Poly(ethylene glycol) Polyethyleneimine H302 H318 H317H412 P273 P280 P305+P351+P338 Potassium acetate Potassium chloride Potassium fluoride H301 H311 H331 P261 P280 P301+P310 P311 Potassium formate Potassium iodide H302 H315 H319 P305+P351+P338 Potassium phosphate dibasic Potassium phosphate monobasic Potassium sodium tartrate tetrahydrate Potassium sulfate Sarcosine Sodium acetate trihydrate Sodium bromide Sodium chloride Sodium citrate tribasic dihydrate Sodium fluoride H301 H315 H319EUH032 P301+P310 P305+P351+P338 Sodium formate Sodium iodide H315 H319 H400 P273 P305+P351+P338 Sodium malonate dibasic monohydrate Sodium nitrate H272 H302 P220 P261 P305+P351+P338 H315H319H335 Sodium oxamate Sodium phosphate dibasic- are these anhydrous? Sodium phosphate monobasic monohydrate Sodium sulfate Sodium tartrate dibasic dihydrate Spermidine Spermine tetrahydrochloride H315 Sucrose Tris(2-carboxyethyl)phosphine hydrochloride Urea Zinc chloride H302 H410 P273 P280 P305+P351+P338 P310 P501 β-nicotinamide adenine dinucleotide phosphate, reduced tetra(cyclohexylammonium) salt β-nicotinamide adenine dinucleotide, reduced dipotassium salt H315 H319 H335 P261 P305+P351+P338

3 4. FIRST AID MEASURES 4.1 Description of first aid measures General notes Consult a doctor. Show this safety datasheet to the doctor in attendance Following inhilation Move to fresh air. If not breathing, give artifical respiration. Seek immediate medical attention Following skin contact Take off contaminated clothing & shoes immediately. Wash with soap & water. Seek immediate medical attention Following eye contact Rinse thoroughly for at least 15 minutes. consult a doctor. Following ingestion Do NOT induce vomiting. Rinse mouth with water. Seek immediate medical attention. Self-protection for first aider Always use recommended PPE when treating patient 4.2 Most important symptoms and effects, both acute and delayed The most important known effects are detailed in section 2.2 and section Indication of any immediate medical attention and special treatment needed 5. FIRE-FIGHTING METHODS 5.1 Extinguishing media Use dry chemical powder 5.2 Special hazards arising from the substance or mixture May contain: Carbon oxides, sodium oxides, potassium oxides, sulfur oxides, nitrogen oxides, arsenic oxides, magnesium oxides, hydrogen chloride gas, hydrogen bromide gas, nickel oxides, calcium oxides, hydrogen fluoride gas, hydrogen iodide gas, phosphorous oxides 5.3 Advice for firefighters Wear breathing apparatus. Use water spray to cool unopened containers 6. ACCIDENTAL RELEASE MEASURES 6.1 Personal precautions, protective equipment and emergency proceedures Use personal protective equipment including respiratory protection. Avoid breathing vapours 6.2 Environmental precautions Do not let product enter drains 6.3 Methods and materials for containment and clean up Evacuate personnel to safe areas. Remove all sources of ignition. Use spill kit to contain spillage & use wet brushing to place in container. Do not flush with water 6.4 Reference to any other sections For disposal see section HANDLING AND STORAGE 7.1 Precautions for safe handling For precautions see section Conditions for safe storage, including any incompatabilities Store in cool place. Keep container tightly closed in well-ventilated place. Containers which are opened must be carefully resealed and stored upright to prevent leakage 7.3 Specific end use Appart from uses in section 1.2, no other specific uses are stipulated 8. EXPOSURE CONTROLS/PERSONAL PROTECTION 8.1 Control parameters Chemical CAS No. STEL Control parameter TWA Control parameter Adenosine 5'triphosphate disodium salt hydrate STEL 250ppm TWA 200ppm Ammonium chloride TWA 10mg/m3 Ammonium fluoride TWA 2.5mg/m3 Cobalt(II) chloride hexahydrate TWA 0.1mg/m3 Ethylene glycol STEL 40ppm TWA 20ppm Glycerol TWA 10mg/m3 Iron(III) chloride hexahydrate STEL 2mg/m3 TWA 1mg/m3 Manganese(II) chloride tetrahydrate TWA 0.5 mg/m3 Nickel(II) chloride hexahydrate TWA 0.1mg/m3 Potassium fluoride TWA 2.5mg/m3 Sodium fluoride TWA 2.5mg/m3 Sucrose STEL 20mg/m3 TWA 10mg/m3 Zinc chloride STEL 2mg/m3 TWA 1mg/m3 8.2 Exposure controls Appropriate engineering controls Wash hands before work break and at the end of the day Personal protection Eye/face protection Face shield & safety specs Skin protection Nitrile gloves (splash protection only) and lab coat Respiratory protection Use respirators and components tested and approved under appropriate government standards such as CEN (EU) as back up to engineering control. Environmental exposure controls Do not let product enter drains 9. PHYSICAL AND CHEMICAL PROPERTIES a) Appearance : Transparent liquid b) Odour : c) Odour threshold : d) ph : e) Melting point / freezing point : f) Initial boiling point and boiling range : g) Flash point : h) Evapouration rate : i) Flammability : j) Upper / lower flammability or exposure limits : k) Vapour pressure : l) Vapour density : m) Relative density : n) Solubility(ies) : o) Partition coefficient: n-octanol / water : p) Auto-ignition temperature : q) Decomposition temperature : r) Viscostiy : s) Explosive properties : t) Oxidising properties :

4 10. STABILITY AND REACTIVITY 10.1 Reactivity : 10.2 Chemical stability : 10.3 Possibility of hazardous reactions : 10.4 Conditions to avoid : 10.5 Incompatible materials : Strong oxidising agents, Strong acids, Strong bases 10.6 Hazardous decomposition materials :. In case of fire see section TOXICOLOGICAL INFORMATION 11.1 Information on toxilogical effects (mixtures) a) Acute toxicity : b) Skin corrosion / irritation : c) Serious eye damage / irritation : d) Respiratory or skin sensitization : e) Germ cell mutagenicity : f) Carcinogenicity : g) Reproductive toxicity : h) STOT - single exposure : i) STOT - repeated exposure : j) Aspiration hazard : Delayed and immediate effects as well as chronic effects from short to long term exposure Symptoms Central nervous system depression, nausea, headache, vomiting, narcosis. Damage to heart. Kidney irregularities. Dermatitis. Salivation, nausea, vomiting, fever. Material is extremely distructive to mucuos membranes & upper respiratory tract Burning sensation, cough, wheezing, laryngitis, shortness of breath,headache, nausea, vomiting. Material is extermely destructive to tissue of mucous membranes & upper respiratory tract. Nausea, headache, fatigue Early symptoms of ingestion similar to drunkeness, leading to nausea, vomiting, abdominal pain, weakness, muscle tenderness, respiratory failure, convulsions, cadiovascular, collapse, pulmonary edema. Without treatment, death may occur in 2h to 24h. Long term affects include renal failure, brain and liver damage. Consumption of alcohol may increase toxic effects. Nausea, vomiting, urine discolouration, ataxia, peripheral sensory neuropathy. May cause allergic reaction & flushing in contact with skin. Headache, nausea, vomiting. May cause kidney irregularities. May cause liver irregularities Material is extremely destructive to mucous membranes & upper respiratory tract. Overdose of iron compounds may have corrosive effect on gastrointestinal mucosa, followed by necrosis, perforation & stricture formation. Several hours later symptoms may occur: epigastric pain, diarrhea, vomiting, nausea, hematemesis. After apparent recovery, person may experience matabolic acidosis, convulsions, coma. Other complications: acute liver necrosis, resulting in death. Spasm, inflammation & edema of larynx & bronchi, pneumonitis, pulomnary edema, burning sensation, cough,wheezing, laryngitis, shortness of breath, headache, nausea, vomiting Gastorinterstinal disturbance Reversible liver enzyme abnormalities Cough, shortness of breath, headache, nausea, vomiting Prolonged exposure to iodides may produce iodism. Symptoms include: skin rash, running nose, headache, irritation of mucous membrane. Sever cases: pimples, boils, hives, blisters, black & blue spots. Iodides readily diffuse across the placenta & can cause neonatal death. Known to cause drug-induced fevers for short periods. Sedation Vomiting, diarrhoea, dehydration, congestion in internal organs. Inflammatory reactions in gastrointestinal tract Damage to lungs Absorption into body leads to formation of methemoglobin which causes cyanosis Material is extremely destructive to mucous membranes & upper respiratory tract, eyes & skin 12. ECOLOGICAL INFORMATION 12.1 Toxicity : 12.2 Persistence and degradability : 12.3 Bioaccumulative potential : 12.4 Mobility in soil : 12.5 Results of PBT and vpvb assessment : 12.6 Other adverse effects : 13. DISPOSAL CONSIDERATIONS 13.1 Waste treatment methods Product / packaging disposal Dispose of packaging as unused product. Offer surplus and non-recyclable soluitions to a licensed disposal company Observe all EU and local environmental regulations 14. TRANSPORT INFORMATION 14.1 UN number A.R.D./R.I.D I.M.D.G I.C.A.O.-T.I A.D.N UN proper shipping name A.R.D./R.I.D. Environmentally hazardous substance, liquid, n.o.s. I.M.D.G. Environmentally hazardous substance, liquid, n.o.s. I.C.A.O.-T.I. Environmentally hazardous substance, liquid, n.o.s. A.D.N. Environmentally hazardous substance, liquid, n.o.s Transport hazard class(es) A.R.D./R.I.D. 9 I.M.D.G. 9 I.C.A.O.-T.I. 9 A.D.N Packaging group A.R.D./R.I.D. II I.M.D.G. II I.C.A.O.-T.I. II A.D.N. II 14.5 Environmental hazards A.R.D./R.I.D. yes I.M.D.G. yes I.C.A.O.-T.I. yes A.D.N. yes 14.6 Special precautions for user A.R.D./R.I.D. I.M.D.G. I.C.A.O.-T.I. A.D.N. 15. REGULATORY INFORMATION 15.1 Safety, health and environmental regulations / legislation specific for the substance of mixture 15.2 Chemical safety assessment For this product a chemical safety assesment was not carried out

5 16. OTHER INFORMATION a) Changes since last revision First issue b) Key to any abbreviations used PPE Personal protective equipment A.R.D./R.I.D. International Carriage of Dangerous Goods by Road / Rail I.M.D.G. International Maritime Dangerous Goods I.C.A.O.-T.I. Technical Instructions for the Safe Transport of Dangerous Goods by Air A.D.N. International Carriage of Dangerous Goods by Inland Waterways c) References and sources for data sigma-aldrich.com d) Indication of methods used for classification (mixtures only) e) List of Hazard and Precautionary phrase not listed in full in other sections See section 2.1 f) Advice for training for workers to ensure protection to human health and environment Disclaimer The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Molecular Dimensions Ltd., shall not be held liable for any damage resulting from handling or from contact with the above product.