An Overview on the Global Market of Dietary Supplements

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2 An Overview on the Global Market of Dietary Supplements Abbas Kebriaeezadeh 1 and Alireza Yektadoost 2 Department of Pharmacoeconomics & Pharmaceutical Administration Faculty of Pharmacy, Tehran University of Medical Sciences 1- Pharm.D., PhD of Toxicology & Head of Department 2- Pharm.D., PhD Candidate of Pharmacoeconomics & Pharmaceutical Administration

3 Dietary Supplement Definition Food supplement or Nutritional supplement For supplementing the diet and supplying nutrients that may be absent in a person's diet or may not be consumed in sufficient quantities. A concoction of several vitamins, minerals, fiber, fatty acids, amino acids and other trace elements. Can be consumed in form of: pill, tablet, capsule, softgel, powder, or liquid.

4 Nutraceuticals Segments Nutraceuticals Functional /Medicinal Foods Functional Beverages Dietary Supplements Probiotic Fortified Foods Energy Drinks Vitamin & Mineral Supplements Omega FA Fortified Foods Sports Drinks Herbal Supplements Milk & Dairies, Wheat Flour, Iodinated Salt Fortified Juices Protein Supplements

5 Nutrition Supplement Requirement Lifestyle Wellbeing Vitality Beauty Energy Preventive & Proactive Age related Infant Nutrition Weight management Site specific Goal oriented Clinical Medical foods Nutrigenomics Food as dosage

6 Categories & Components of Dietary Supplements Categories Specialty Supplements Sports Nutrition Meal Replacements Components Herbs/Botanicals Vitamins Minerals Amino Acids

7 A Brief History of Dietary Supplements 1995: The Year of Melatonin 2004: The Year of Fish Oil 1996: The Year of Echinacea 2005: The Year of Vitamin E 1997: The Year of St. John s Wort 2006: The Year of Obesity 1998: The Year of Glucosamine 2007: The Year of Probiotics 1999: The Year of SAMe 2009: The Year of Vitamin D 2003: The Year of Ephedra

8 Global Nutrition Market In billion USD : US$ b 2013: US$ b % Growth CAGR : 6.92% Source: KONCEPT ANALYTICS

9 Global Nutrition Industry Forecast 2014F 2018F CAGR = 6.87% f 2015f 2016f 2017f 2018f Source: KONCEPT ANALYTICS

10 Global Nutrition Industry by Segments 2013 Infant Nutrition 24% Functional Food & Beverages 47% Dietary Supplements 29% Source: KONCEPT ANALYTICS

11 Global Dietary Supplements Market In billion USD : US$ b 2013: US$ b % Growth CAGR : 6.2% Source: KONCEPT ANALYTICS

12 Global Nutrition Supplement Market by Segments Share Meal Replacements 8% Others 19% Vitamins 34% Minerals 10% Sports Nutritions 12% Herbs & Botanical 17% Source: KONCEPT ANALYTICS

13 Global Nutrition Supplement Market by Segments 2013 Vitamins Herbs & Botanical Sports Nutrition Minerals Meal Replacements Others (US$ Billion) (US$ Billion) (US$ Billion) (US$ Billion) 9.25 (US$ Billion) (US$ Billion)

14 Global Nutrition Supplement Market by Regional Share Region Revenue (US$ b.) North America % 16% 35% Asia Pacific % Europe Other North America Asia Pacific Europe Other Source: KONCEPT ANALYTICS

15 Global Dietary Supplement Market Forecast 2014F 2018F CAGR = 6.73% f 2015f 2016f 2017f 2018f Source: KONCEPT ANALYTICS

16 Global Rx Pharmaceuticals vs. Nutraceuticals & Nutrition Supplement Market % CAGR % CAGR Sources: IMS, EVALUATE-PHARMA, & KONCEPT ANALYTICS

17 Global Vitamin Market 2009 to 2013 & 2014 to 2018 forecast CAGR = 3.24% CAGR = 4.1% f 2015f 2016f 2017f 2018f Source: KONCEPT ANALYTICS

18 Global Sports Nutrition Market Performance enhancers, metabolic/fat burners, muscle builders, meal replacements, weight gainers, and energy formulas. In tablet, powder or ready-to-drink forms. These products are targeted at athletes and gym-goers. They contain one or more of the following ingredients: Soy protein, whey protein, Creatine, L-Carnitine and Amino acids. While powders account for the majority of the market, protein bars and ready-to-drink protein beverages have been growing at a faster rate.

19 Global Sports Nutrition Market 2009 to 2013 & 2014 to 2018 forecast 25 CAGR = 12.82% CAGR = 10.4% f 2015f 2016f 2017f 2018f Source: KONCEPT ANALYTICS

20 Global Mineral Market 2009 to 2013 & 2014 to 2018 forecast CAGR = 11.5% CAGR = 11.21% f 2015f 2016f 2017f 2018f Source: KONCEPT ANALYTICS

21 Nutrition Supplement Industry North America vs. Asia Pacific : US$ billion (CAGR: 5.43%) 2018: US$ billion (CAGR: 6.1%) 2013: US$ billion (CAGR: 5.55%) 2018: US$ billion (CAGR: 4.89%) Minerals 9% Others 23% Meal Replacem ents 6% Herbs & Botanical 12% Vitamins 29% Sport nutritions 21% Meal Replacem ents 8% Minerals 13% Others 17% Herbs & Botanical 16% Sport nutritions 3% Vitamins 43%

22 Market of Dietary Supplements in Iran 2012 Tonics, 1.1% Co-Q10, 0.5% Fish Oils, 1.7% Protein DS, 1.8% Herbal DS, 4.9% Paediatric DS, 7.4% Glucosamine, 8.1% Other, 3.0% Multivitamins, 34.4% Single Vitamins, 15.7% Minerals, 21.5% Source: Euromonitor International

23 Targets of Supplement Use Iran Bone, 16% Joint, 10% Beauty, 5% Digestive, 2% Sexual Health, 2% Memory Health, 1% Other, 3% Immune System, 1% Energy, 1% General Health, 62% Source: Euromonitor International

24 Vitamin Market Iran vs. UK 0.5% 6.6% 1.0% Multivitamins Vitamin A 2.4% 2.4% 1.8% Multivitamins Vitamin A 8.8% Vitamin B 17.3% Vitamin B 13.8% Vitamin C Vitamin C 0.6% 68.8% Vitamin D Vitamin E 0.7% 8.8% 66.6% Vitamin D Vitamin E Other Single Vitamins Other Single Vitamins Source: Euromonitor International

25 Market Dynamics Growth Drivers Increasing Global Healthcare Expenditure Shift from Rural to Urban Regions Accelerating Aging Population Increasing Life Expectancy Rate Ameliorating Economic Conditions Rising Number of Vitamin D Tests

26 Increasing Global Healthcare Expenditure Per Capita (US$) CAGR: 4.56% Source: World Bank

27 Shift from Rural to Urban Regions Billion CAGR: 2.14% Source: World Bank billion

28 Accelerating Aging Population (over 65 years) 7.9% 7.8% 7.8% 7.7% CAGR: 2.56% 7.7% 7.7% 7.8% 7.7% 7.6% 7.6% 7.6% 7.5% 7.5% 7.5% 7.4% 7.4% Source: World Bank

29 Increasing Life Expectancy Rate CAGR: 0.34% Source: World Bank

30 Ameliorating Economic Conditions Global GDP - US$ Trillion CAGR: 5.24% Source: World Bank

31 Rising Number of Vitamin D Tests Million of Test/Year CAGR: 41.46% E 2013E 40% of the EU population, (~150 million) are Vitamin D deficient, but <5% of them get tested.

32 Trends and Developments Rising Prevalence of Dietary Supplements Increasing Demand for Liquid Dietary Supplements Increased Acceptance of Infant Nutrition Focus on Novel Nutrition Ingredients

33 Rising Prevalence of Dietary Supplements among Adult Population (2013) 60.0% 50.0% 56.7% 53.3% 40.0% 41.1% 34.4% 30.0% 20.0% 26.7% 24.4% 10.0% 11.1% 11.1% 4.4% 0.0% Denmark US UK Sweden Netherland Germany Italy Spain Greece

34 Dietary Supplements Use by Age Max: 3-5 years Min: years >20 years 81% Pregnant women >50% of age >65 years Adapted from Dietary Supplement Barometer Survey

35 Dietary Supplements Use by Education Level Adapted from Dietary Supplement Barometer Survey

36 Dietary Supplements Use by Income Adapted from Dietary Supplement Barometer Survey

37 Dietary Supplements Use by Reason Autonomy Adapted from Dietary Supplement Barometer Survey

38 Increased Acceptance of Infant Nutrition Infant nutrition market is gaining popularity at a swift pace principally driven by increasing conscious of parents regarding the health of their offspring. Nucleotides Choline Taurine DHA Vitamins Minerals (e.g. Fe, Ca, Mg, Zn, I, Cu)

39 References & Acknowledgments Global Nutrition Supplement Market Report: May 2014 (KONCEPT ANALYTICS) VITAMINS AND DIETARY SUPPLEMENTS IN IRAN: August 2013 (Euromonitor International) And With acknowledgments to: LIVAR PHARMACEUTICAL & HYGIENIC COMPANY

40 Thanks For Your Kind Attention