Stephanie R. (nee Anderson) Harris

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1 Stephanie R. (nee Anderson) Harris Department of Nutrition Current Residence: Case Western Reserve University 2077 East 4 th Street 8W Cleveland, Ohio Cleveland, Ohio Phone: (216) Phone: (440) Fax: stephanie.harris@case.edu Education PhD, Nutritional Biochemistry and Human Metabolism, August 2011 Department of Nutrition, Case Western Reserve University, Cleveland Ohio MS, Clinical Nutrition, December 2006 Department of Nutrition, Case Western Reserve University, Cleveland Ohio RD, Dietetic Internship in Food Service, Clinical and Public Health Nutrition, August 2006 University Hospitals Case Medical Center, Cleveland Ohio BS, Nutrition Food & Agriculture, May 2004 Nutritional Sciences Department, Cornell University, Ithaca New York Employment and Professional Experiences Assistant Professor, September 2012 present Instructor for undergraduate courses: NTRN 363 Human Nutrition I: Energy, Protein & Minerals, NTRN 366 Nutrition for the Prevention and Management of Disease: Clinical Applications. Instructor for graduate courses: NTRN 433 Advanced Human Nutrition I, NTRN 438 Dietary Supplements. Lecturer for medical school students (topics: vitamins, minerals and dietary supplements). Advisor for undergraduate students. Mentor/preceptor for graduate student research. Post-Doctoral Fellow, August 2011 August 2012 Investigated new fates of levulinate (4-ketopentanoate) metabolism in liver, heart and brain. Identified the formation of cyclical C 7 -CoA esters derived from levulinate, which may contribute to its toxicity via binding to the ε-n of lysine residues of proteins in liver, heart or brain. NB: Levulinate is food additive approved by the FDA. As a calcium salt, it is used as an oral and intravenous source of calcium supplementation. Research Mentor, NTRN 601 Special Problems: Research, January 2012 August 2012 Mentored one graduate student in a bench science research project Activities included teaching (i) analytical techniques using GC- and LC-MS methodology, (ii) the use of stable isotope tracers in metabolic research studies, (iii) the development/design of animal research protocols and organ perfusion techniques, and (v) data analysis and interpretation. Instructor, NTRN 363 Human Nutrition 1: Energy, Protein, Minerals, August 2011 December 2011 Instructor for undergraduate course focused on (i) macronutrients and minerals (e.g. experimental basis of human requirements, metabolic roles, and clinical signs/symptoms of deficiency and toxicity),

2 and (ii) the application of nutrition science and research results to the solution of clinical problems. PhD Student, August 2008 August 2011 Investigated the metabolism of levulinate and its conversion to 4-hydroxypentanoate (a drug of abuse and analog of 4-hydroxybutyrate), in perfused rat livers, liver subcellular preparations, and in live rats. Identified the pathway of levulinate and 4-hydroxypentanoate catabolism in mammalian cells using metabolomics and mass isotopomer analysis. Characterized the potential toxic effects of calcium levulinate (± ethanol) on intermediary metabolism. LeCharles Bentley O-Line Academy, Avon Ohio Consultant Dietitian, November 2009 May 2010 Developed sports nutrition education materials on macronutrient intake, hydration, supplement use, and snacking guidelines for participating football athletes. Analyzed the nutrient composition of diets for athletes requiring weight maintenance, loss, or gain. University Hospitals Case Medical Center, Department of Infectious Disease, Cleveland Ohio Clinical Dietitian & Research Associate, November 2006-August 2008 Provided outpatient medical nutrition therapy for children and adults with HIV/AIDS. Developed nutrition education materials and nutrient regimens for patients with food allergies, eating disorders, renal disease, diabetes, cancer, cardiovascular disease, wasting, and other disorders. Participated in grant writing and project management for human research on fat redistribution and metabolism, antioxidant supplementation, and resting metabolic rate in HIV disease. Preceptor for MS/RD interns Mentored a graduate student research project on the effect of micronutrient supplementation on antiretroviral therapy / t-cell count in HIV/AIDS. Clinton Foundation, Princess Margaret Hospital, Nassau Bahamas Clinical Nutrition Educator, June 2008-July 2008 Provided lecture-based nutrition education sessions for HIV center staff and public health employees. Assisted in the development of nutrition therapy guidelines for pediatrics and adults living with HIV. Masters Graduate Research Student, August 2005-December 2006 Investigated in vivo protein metabolism in a mouse model of diet-induced obesity and diabetes. Published work in scientific journal and presented research at a SCAN symposium. University Hospitals Case Medical Center, Cleveland Ohio Clinical Dietitian, August 2006-November 2006 Provided inpatient medical nutrition therapy for all stages of the lifecycle. Worked in all clinical care units, including intensive care, women s health, cancer and pediatrics. Healthy for Life Corporate Wellness Program, University Hospitals, Cleveland Ohio Program Coordinator, December 2005-June 2006 Implemented a healthy lifestyle modification and weight loss program for hospital employees. Tasks included weekly nutrition education sessions, dispelling the myths of weight loss and supplement use, and motivational employee weigh-ins. Christ Hospital, Jersey City New Jersey Nutrition Office Assistant, August 2004-August 2005 Assisted in hospital inpatient menu development, food selection based on patient diagnosis, and with the nutrition risk-screening process for newly admitted patients. Audited patient charts to screen for proper nutrition care recommendations and follow-up procedures.

3 Cornell University, Nutritional Sciences Department, Ithaca New York Undergraduate Research Assistant, May 2002-May 2003 Developed nutrition education resources for women in the low-income sector (i.e. Get Fresh Project). Collaborated with the New York State Department of Health and Farmer s Market Nutrition Program to distribute education resources and analyze participant questionnaires to assess material usefulness. Cornell University, Introduction to Nutritional Sciences Course, Ithaca New York Undergraduate Teaching Assistant, August 2002-December 2002 Led weekly discussions and lectures for a section of students on course-related nutrition topics. Formulated exam questions based on course content and evaluated written research papers. Professional Activities and Leadership Alzheimer s Association, Cleveland Chapter Young Professionals Board Member and Blond vs. Brunette s Co-Chair, 2011-present Boys Hope Girls Hope, Northeastern Ohio Chapter Associate Board Member and Program Development Co-Chair, 2011-present Cornell Alumni Admissions Ambassador Network, Undergraduate Applicant Interview Committee, 2007-present American Society of Nutrition, Active Member, 2011-present Academy of Nutrition and Dietetics, Active Member, 2006-present Academy of Nutrition and Dietetics, Dietetics Practice Groups (DPG) o Dietitians in Integrative and Functional Medicine DPG, 2013-present Executive Committee Member and Treasurer, present o Nutrition Educators of Health Professionals DPG, 2013-present o Sports, Cardiovascular and Wellness Nutrition DPG, 2014-present Journal of the Academy of Nutrition and Dietetics, Manuscript Reviewer, 2013-present Case Western Reserve University o Faculty Senate Committee on Undergraduate Education (FSCUE) Curriculum Subcommittee, School of Medicine Representative, 2013-present o Department of Nutrition, Appointment, Promotion and Tenure (APT) Committee, present o Department of Nutrition, Search Committee Chair, 2014-present o Women Faculty of the School of Medicine (WFSOM) Steering Committee, present W.H. Freeman Textbook Reviewer, Textbook title Scientific American Environmental Science for a Changing World, December 2012 Project-present Northeastern Ohio Science and Engineering Fair, Behavioral Health and Human Medicine Project Judge, 2007-present Diabetes Association of Greater Cleveland, Ohio Dietetic Association, Cleveland Dietetic Association, Active Member, Case Western Reserve University Biomedical Graduate Student Symposium, Committee Member and Fund Development Co-Chair, Commission on Accreditation for Dietetics Education, University Site Reviewer, Teaching Awareness & Linking Knowledge, University Hospitals Case Medical Center Special Immunology Unit Group Educator, AIDS Task Force, Food Pantry & Cooking Demonstration Class Coordinator, Hope for Honduran Children Fund, Medical Brigade Volunteer in Honduras,

4 Awards and Honors Ohio Academy of Nutrition and Dietetics, 2015 Recipient of Outstanding Dietetic Educator of the Year, January National Institute of Health Travel Award, The Mary Frances Picciano Dietary Supplement Research Practicum, June 2013 Case Western Reserve University, John S. Diekhoff Award for Distinguished Graduate Student Teaching. Nominee, Research publication feature in Chemical Research in Toxicology, Article selected by editors for feature in the In This Issue section of the CRT journal. February The American Society for Biochemistry and Molecular Biology, Chemical Biology and Catalysis Best Thematic Poster Award. ASBMB Annual Meeting in San Diego, California Case Western Reserve University, Carl F. Wittke Award for Excellence in Undergraduate Teaching. Nominee, SCAN Dietetic Practice Group Research Poster Symposium, Graduate student winner for project titled Activation of Protein Synthesis in a Mouse Model of Type 2 Diabetes Cleveland Dietetic Association, Karen A. Porcelli Education Scholarship Recipient Case Western Reserve University Department of Nutrition, Graduate Alumni Fund Scholarship Recipient Outstanding Senior Service Award, College of Agriculture and Life Sciences, Cornell University Cornell Undergraduate Research Award, Student Feature for research on the Get Fresh Project! New York State Farmer s Market Nutrition Program Invited Presentations, Posters, and Abstracts Dietary Supplement Use Among the Undergraduate College Population. Co-Author for abstract submitted for presentation at Experimental Biology Annual Meeting Boston, Massachusetts. March Short Sleep Duration: Effects on Nutrient Intake and Mood State. Co-Author for abstract submitted for presentation at Experimental Biology Annual Meeting Boston, Massachusetts. March "The Effects of Human Immunodeficiency Virus and Antiretroviral Therapy on Resting Energy Expenditure in Adult HIV-Infected Women: A Matched, Prospective, Cross-Sectional Study. Journal of the Academy of Nutrition and Dietetics Podcasts. Live interview completed on April 16, (DOI: /j.jand ) Potential of the association of metabolomics and stable isotope technologies (isotopomics) for pathway discovery. Co-Author for keynote speaker presentation at the Belgian Society of Biochemistry and Molecular Biology Annual Meeting. University of Namur. Namur, Belgium. November Cyclical C 7 -CoA Esters Derived from Calcium Levulinate, a Pro-Drug of Abuse. Oral presentation given at the Metabolomics Symposium, ASBMB Annual Meeting. San Diego, California. April 2012

5 The Effects of Human Immunodeficiency Virus and Antiretroviral Therapy on Resting Energy Expenditure in Adult HIV-Infected Women. Co-Author for abstract selected for oral presentation at Clinical Nutrition Week Conference, ASPEN. Orlando, Florida. January Calcium Levulinate: Pro-Drug of Abuse. Conversion to Cyclical C 7 CoA Esters. Poster presented at Experimental Biology; ASBMB Annual Meeting Washington, D.C. April Calcium Levulinate: Dietary Supplement and Pro-drug of Abuse. Poster presented at Experimental Biology; ASBMB Annual Meeting Anaheim, California. April The Metabolism of Levulinate in Perfused Rat Livers and Live Rats. Poster presented at Case Western Reserve University Research Showcase Cleveland, Ohio. April Positive Nutrition: Eating to Liver Better. Ulmer & Berne Attorneys LLP, wellness session for employees. Cleveland, Ohio. August The Basics: Nutrition and HIV & Nutrition: A Co-Factor in HIV/AIDS Progression. Clinton Foundation, training session for Ministry of Health HIV Center employees. Nassau, Bahamas. June Pediatric Nutrition and HIV. Clinton Foundation, training session for Ministry of Health pediatric attending physicians and medical students. Nassau, Bahamas. June Positive Nutrition. Clinton Foundation, training session for HIV/AIDS Resource Committee members. Nassau, Bahamas. June Nutrition and HIV Research Update. Cleveland Dietetic Association, general membership meeting. Shaker Heights, Ohio. November Profession of Nutrition and Dietetics. John Carroll University, undergraduate student seminar. Cleveland, Ohio. November 2007 Activation of Protein Synthesis in a Mouse Model of Type 2 Diabetes. Poster presented at the Sports, Cardiovascular, and Wellness Nutritionists Dietetic Practice Group Annual Meeting. Nashville, Tennessee. April Protein Synthesis in Diet-Induced Obesity and Type 2 Diabetes. Abbott Nutrition Ross Labs, summer internship seminar. Columbus, Ohio. June Calcium Intake after Gastric Bypass Surgery. University Hospitals of Cleveland, patient seminar. Cleveland, Ohio. February Publications 1. Connor R, Ciadella-Kam L, Harris SR. A survey of medical students use of nutrition resources and perceived competency in providing basic nutrition education. Journal of Biomedical Education. Accepted November 2014, In Press. 2. Sadhukhan S, Li Q, Han Y, Harris SR, Tochtrop GP, Zhang GF. Measuring the mass isotopomer distribution of metabolites by tandem mass spectrometry via a single fragment. Rapid Communications in Mass Spectrometry. Submitted October Mittelsteadt A, Hileman C, Harris SR, Payne K, Gripshover B, McComsey G. Effects of HIV and antiretroviral therapy on resting energy expenditure in adult HIV-infected women A matched, prospective, cross-sectional study. Journal of the Academy of Nutrition and Dietetics. August 2013; 113 (8): Harris SR, Zhang GF, Sadhukhan S, Wang H, Shi C, Puchowicz MA, Anderson VE, Salomon RG, Tochtrop GP, Brunengraber H. Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: Pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate. Chemical

6 Research in Toxicology. February 2013; 26 (2): Harris SR, Zhang GF, Sadhukhan S, Murphy AM, Tomcik KA, Vasquez EJ, Anderson VE, Tochtrop GP, Brunengraber H. Metabolism of levulinate in perfused rat livers and live rats: Conversion to the drug of abuse 4-hydroxypentanoate. The Journal of Biological Chemistry. February 2011; 286(7): Anderson SR, Gilge DA, Steiber AL, Previs SF. Diet-induced obesity alters protein synthesis: Tissue-specific effects of fasted vs. fed mice. Metabolism. March 2008; 57(3):

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