EXCELLENCE IN YEAST EXCELLENT FOR FISH REAL BREWERS YEAST

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1 EXCELLENCE IN YEAST EXCELLENT FOR FISH Made in Germany REAL BREWERS YEAST

2 Leiber specialized brewers yeast products are recommended for: Fish Crustaceans Leiber Excellence in Yeast Leiber GmbH has been supplying customers world- wide with premium Made in Germany brewers yeast products since 1954 in the fields of animal feed, the food industry and food supplements. Using a patented process to dry the yeast, Leiber manufactures brewers yeast products and yeast extracts to the highest level of quality at two sites in Germany and other production sites in Poland and Russia, with over 180 employees. Multibiotic power from yeast for the good health and performance of your animals Cattle Poultry Pigs Horses Nikolaus Jungbluth, Business Unit Director Animal Nutrition Natural raw materials Sheep Modern patented technology Quality products Made in Germany Products are not genetically modified, recognised by InfoXgen and Fibl Individual scientific advice Leiber is ISO 22000:2005 and QS certified as well as GMP+ recognised Kosher & Halal certified Pets The biological value of a feed mix should not just be measured in terms of energy, protein, minerals and vitamins. Significantly important for an animal s performance is the bioavailability of nutrients and active ingredients which can be greatly increased using Leiber Brewers Yeast products. Their multibiotic action is an important contribution to animal health and performance.

3 Leiber Beta-S (1,3)-(1,6)-β-D-glucans > 80% for strong, immunocompetent fish Growth performance and health of fish and crustacea is directly related to the use of advanced, nutrient-rich feed. This lays the foundations for strong and healthy stocks. Intestine (1,3)-(1,6)-β-D-glucan M cell Epithelial cells B cell Leiber Beta-S recommended usage: g/t in feed ( %) In juvenile nutrition it supports the build-up of immunity and antibody production In intensive fish farming it ensures long term reduction in infection levels Before periods of expectable increased stress and emergence of pathogens to prevent/reduce losses. Improves effectiveness of vaccinations programmes (immune response) GALT Macrophage Leiber Beta-S ingredients: 100% Brewers yeast (Saccharomyces cerevisiae) Leiber Beta-S consists of highly pure (1,3)-(1,6)-β-D-glucan molecules from the cell wall of brewers yeast cells. By a particularly gentle process, developed by Leiber, the (1,3)-(1,6)-β-D-glucan molecules are isolated from the brewers yeast cell walls. The native structure of the glucan molecules is retained. As a result, their full biological activity is guaranteed and Leiber Beta-S has an active immune-modulating effect during intestinal passage. Due to high levels (> 80%) of isolated (1,3)-(1,6)-β-D-glucan Leiber Beta-S is able to effectively relieve the animals metabolism and immune system in a long lasting manner. Scientifically proven effects on fish and crustacea using Leiber Beta-S: Improvements in non-specific cellular and humoral immunity Increased survival rates in infections Pronounced adjuvant effect in vaccinations Improved feed conversion Maintaining of these effects also with continual use (proven for up to 6 months) Crude protein 4.0% Crude oils and fats 4.0% Crude fibre 0.5% Crude ash 3.0% Lysine 0.2% Methionine 0.1% Microbiology Aerobic mesophilic germs (CFU/g) < 8,000 Salmonellae (CFU/25g) neg. Polysaccharides (1,3)-(1,6)-β-D-glucan > 80% Mannan < 2% Chitin < 1% Bulk density 510kg/m 3 ph value (typical) 4.8 light beige 2

4 Leiber Brewers Yeast unextracted More than just the sum of its ingredients In the composition and processing of Leiber Yeast products, the highest quality standards apply. The production method ensures maximum protection of the sensitive components and active ingredients of brewers yeast. Mitochondrion Endoplasmic reticulum Leiber Brewers Yeast recommended usage: 10 50kg/t in feed (1 5%) Due to the high levels of B vitamins and trace elements, Leiber Brewers Yeast is particularly recommended for brood stock and juvenile nutrition for all varieties of fish and crustacea. Nucleus Golgi apparatus Cell wall Leiber Brewers Yeast ingredients: 100% Brewers yeast (Saccharomyces cerevisae) Lysozyme Vacuole Leiber pure Brewers Yeast consists of brewers yeast (100% Saccharomyces cerevisiae). The dietary and prebiotic effect of Leiber Brewers Yeast with its many valuable and highly available ingredients (enzymes, B vitamins, amino acids and minerals) give an added value to any fish feed mix. Crucially, brewers yeast, unlike other feed yeasts, contains the valuable hop components Humulone (α-acid) and Lupulone (β-acid). Supplementing feed with Leiber Brewers Yeast has a positive effect on animal performance and health. Benefits of Leiber Brewers Yeast: Dietary and prebiotic effect Stabilization of the gastro-intestinal system Humulones & Lupulones (α- and β-acids from hops) with antioxidant and bacteriostatic effect Crude protein 46.0% Crude oils and fats 2.7% Crude fibre 1.0% Crude ash 8.0% Water/Moisture 6.0% Lysine 3.2% Methionine 0.6% Calcium 0.2% Phosphorus 1.4% Sodium 0.2% Trace elements per kg Iron 480mg Zinc 100mg Manganese 50mg Copper 60mg Selenium 1mg Bulk density 600kg/m 3 ph value (typical) 5.8 light brown Odour typical for brewers yeast 3

5 Biolex MB40 Mannan-oligosaccharides (MOS) for gut protection and health Biolex MB40 offers the best basis for a good development of fish and crustacean stocks. Studies show that beta-glucans and mannans have a positive effect on the immune system and the stabilisation of the gut microbiota. Surface receptors Mannoproteins Biolex MB40 recommended usage: 0.5 2kg/t in feed ( %) During increased pressure from pathogens and mycotoxins For improved growth and feed conversion Where plant proteins are used in the diet, e.g. soybean meal (enteritis problems) ß-glucans ß-glucan+chitin Mannoproteins Plasma membrane Cell interior Biolex MB40 ingredients: 100% Brewers yeast (Saccharomyces cerevisiae) Biolex MB40 is obtained in the production of soluble brewer s yeast extract. The manufacturing process isolates nucleic acids, purines and other metabolites, concentrates mannan-oligosaccharides and ß-glucans and exposes specifically active segments of the cell wall. Biolex MB40 is characterised by its high levels of (1,3)- (1,6)-β-D glucans and mannan-oligosaccharides (MOS). Its excellent scientifically proven effect is based on its large surface and special surface structure resulting in its high adsorption power. Effects of Biolex MB40 on fish and crustacea: High binding strength and deactivation of pathogens/toxins in the gut lumen Formation of an additional protective barrier (biofilm) on the intestinal mucosa (infection barrier) Support and relief for the immune system, reduced loss rates from infections Potential for binding and deactivation of mycotoxins Prebiotic effect on aquaculture-relevant probiotic bacteria Crude protein 25.0% Crude oils and fats 7.5% Crude fibre 0.5% Crude ash 4.0% Lysine 2.0% Methionine 0.5% Microbiology Aerobic mesophilic germs (CFU/g) < 10,000 Salmonellae (CFU/25g) neg. Polysaccharides (1,3)-(1,6)-β-D-glucan 25 30% Mannans 20 25% Bulk density 500kg/m 3 ph value (typical) 4.5 light brown 4

6 Hydrolyzed Yeast for optimal active ingredient supply of fish CeFi pro consists of the cell contents and the cell walls of brewer s yeast which are extracted by gentle and effective hydrolysis processes from their natural matrix so that the individual cell components are able to optimally take their full effects. A G T C CeFi pro recommended usage: 2 10kg/t in feed ( %) Especially for shrimps due to the high bioavailability of nutrients (short digestive tract and moulting of shrimps) During increased susceptibility to infection In intensive fish farming under stress conditions During spawning to improve reproductive performance For optimization of feed intake ß-glucans and mannan oligosaccharides (MOS) of the cell wall in combination with the natural RNA compo- nents, the nucleotides, nucleosides as well as the pyrimidine and purine bases of the brewer s yeast guarantee the high efficacy of CeFi pro. Thus, CeFi pro is able to support and especially during stress situations to accelerate the natural processes of cell regeneration and cell repair. CeFi pro s effects on fish and crustacea: Increased development and integrity of intestinal tissue especially in early stages of development Higher growth due to the high bioavailability of nucleic acids, nucleotides and nucleosides Improved immunity and resistance during infections and stress Promotes cell division and cell regeneration in reproductions CeFi pro ingredients: 100% Brewers yeast (Saccharomyces cerevisiae) Crude protein 50.0% Crude oils and fats 3.0% Crude fibre 1.0% Crude ash 6.6% Lysine 3.6% Methionine 0.8% Microbiology Aerobi mesophilic germs (CFU/g) < 10,000 Salmonellae (CFU/25g) Cell ingredients Glutathione (in 100g) Choline (in 100g) neg. 600mg 320mg Nucleic acid protein (in CP) 12% Bulk density 660kg/m 3 ph value (typical) 5.3 light brown 5

7 Everyone knows the terms probiotic or prebiotic but what is the multibiotic effect? The effect of brewers yeast is more than just the sum of all its ingredients. Only the combination of ingredients paired with the bioavailability and unique morphology of the yeast cells enables multiple synergistic effects the multibiotic power. Leiber GmbH Hafenstraße Bramsche Germany Tel. +49 (0) Fax +49 (0)

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