Physiology 12. Overview. The Gastrointestinal Tract. Germann Ch 19
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1 Physiology 12 The Gastrointestinal Tract Germann Ch 19 Overview 1
2 Basic functions of the GI tract Digestion Secretion Absorption Motility Basic functions of the GI tract Digestion: : Dissolving and breaking down ingested particles 2
3 Basic functions of the GI tract Digestion: Dissolving and breaking down ingested particles Secretion: : Releasing enzymes, bile and Hydrochloric acid into the lumen of the GI tract Basic functions of the GI tract Digestion: Dissolving and breaking down ingested particles Secretion: Releasing enzymes, bile and Hydrochloric acid into the lumen of the GI tract Absorption: : Moving molecules from the lumen into the blood or lymph Basic functions of the GI tract Digestion: Dissolving and breaking down ingested particles Secretion: Releasing enzymes, bile and Hydrochloric acid into the lumen of the GI tract Absorption: Moving molecules from the lumen into the blood or lymph Motility: : Moving food through the GI Tract 3
4 4
5 Structure of the Gastrointestinal Tract Wall 5
6 Digestion and Absorption of nutrients Carbohydrate Protein Fat 6
7 Digestion and Absorption of nutrients Carbohydrate: Body only absorbs monosaccarides (glucose, fructose, galactose) Enzymes on luminal membrane break down complex sugars into monosacarides Monosaccarides enter body by facilitated difussion Cellulose (fiber) can not be broken down 7
8 Digestion and Absorption of nutrients Protein: Free amino acids and short chains can be absorbed. Enzymes Stomach (pepsin) Small intestine (chymotrypsin( chymotrypsin, Trypsin) Pancreas (Carboxypepsidase( Carboxypepsidase) Small intestine epithelium (Aminopepsidase( Aminopepsidase) Digestion and Absorption of nutrients Carbohydrate Protein Fat: must be Emulsified in lumen before absorbed 8
9 Structure of Bile Salts Emulsification of Fat Fat Digestion/ Lipase 9
10 10
11 Following the pathway of ingested food 11
12 12
13 13
14 Secretions from the Stomach Parietal cells secrete acid Chief cells secrete pepsinogen Enterochromaffin- like cells release histamine into the body 14
15 Conversion of Pepsinogen to Pepsin Regulation of stomach acid secretion 15
16 16
17 Duodenum Jejunum Ileum Small intestine Liver Produces Bile Bile pigments (bilirubin( bilirubin) Has enterohepatic circulation 17
18 18
19 Secretion of Bile is regulated by the hormone Cholecystokinin (CCK) Pancreas Secretes Bicarbonate to neutralize stomach acid Secretes digestive enzymes Trypsin Regulates whole body metabolism via Insulin Glucagon Somatostatin 19
20 Structure of the pancreas 20
21 Regulation of the Pancreas Acid levels in Small Intestine stimulate pancreatic bicarbonate release (via Secretin) Amino and Fatty acids stimulate enzyme release (via Cholecystokinin,, CCK) Small intestine 21
22 Movement of the Small Intestine 22
23 Physiology 12 Regulation of systemic Metabolism Germann Ch 20 23
24 Feast or Famine Everyday the body must shift its metabolism In the fed (absorptive) state Food is being digested or absorbed Energy comes primarily from carbohydrates In the fed (absorptive) state Food is being digested or absorbed Energy comes primarily from carbohydrates Extra carbohydrates are converted to fat (via liver glycogen production) 24
25 In the fed (absorptive) state Food is being digested or absorbed Energy comes primarily from carbohydrates Extra carbohydrates are converted to fat (via liver glycogen production) Ingested fatty acids are stored in adipose In the fed (absorptive) state Food is being digested or absorbed Energy comes primarily from carbohydrates Extra carbohydrates are converted to fat (via liver glycogen production) Ingested fatty acids are stored in adipose Excess amino acids are converted to Fat 25
26 In the Fasted (postabsorptive( postabsorptive) ) state Glycogen and fat production stops In the Fasted (postabsorptive( postabsorptive) ) state Glycogen and fat production stops Liver releases glucose to maintain blood Glucose levels (brain must have glucose) In the Fasted (postabsorptive( postabsorptive) ) state Glycogen and fat production stops Liver releases glucose to maintain blood Glucose levels (brain must have glucose) Most energy comes from Fatty acids and Keytones 26
27 In the Fasted (postabsorptive( postabsorptive) ) state Glycogen and fat production stops Liver releases glucose to maintain blood Glucose levels (brain must have glucose) Most energy comes from Fatty acids and Keytones Muscle breaks down Muscle glycogen for fuel. 27
28 Feast or famine states are regulated by Pancreatic hormones Insulin Glucagon 28
29 The endocrine Pancreas Islet of Langerhans 29
30 Insulin is produced by the Pancreatic islet beta cells, its release is regulated Circulating glucose Circulating amino acids Sympathetic/parasympathetic nerves Other gut hormones 30
31 31
32 Glucagon Secreted from the pancreatic islet alpha cells Stimulated by drops in blood sugar 32
33 Total regulation of metabolism is a balanced equation Food ingested = total energy expended Total energy expenditure = Work + Heat produced + energy stored 33
34 34
35 35
36 36
37 37
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