MULTI-SPECIES DIRECT FED MICROBIAL SUPPLEMENT. Product Catalog June Cedar Falls Road Menomonie, WI

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1 MULTI-SPECIES DIRECT FED MICROBIAL SUPPLEMENT Product Catalog June Cedar Falls Road Menomonie, WI

2 the world leader in DFMs (direct-fed microbials) Probios microbial products are available in many product forms: Powders Boluses Tablets Oral Soft Chews Gels Feed Granules When to use DFMs When animals are under stress, they may experience digestive upsets and reduced appetite. DFMs may help maintain normal appetite and digestion when given to animals during or after times of stress. Some examples of stressful situations that animals may experience are: Change in environment Birthing (freshening) Traveling Kenneling Vet visits Hospitalization Antibiotic therapy Intensive training Change in feed or diet Shipping/Receiving Vaccination DFMs benefit many animals DFMs are effective for a broad range of animal species including: Dairy and beef cattle Poultry Calves Horses Swine Dogs Sheep Cats Goats Other Exotic Pets Contains a source of live (viable), naturally occurring source of microorganisms. Probios is a registered trademark of Chr. Hansen, Inc.

3 Why use the Probios brand? Probios is the world s most widely recognized, researched and used brand of DFMs. Research Quality Stability and viability Manufactured in the U.S.A. More than 95 individual studies have been performed at universities and under practical field conditions throughout the United States and the world. These trials, involving more than 30,000 animals, have shown the positive results of Probios microbial products in a variety of animal species, including dairy, beef, swine and sheep. Additional studies have shown the positive results of Probios microbial products in starter, grower and finisher pigs, chickens, turkeys and horses. The manufacturer of Probios microbial products is able to prove that the product is safe and effective when fed to animals. Probios microbial products contain guaranteed levels of Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei and Lactobacillus plantarum. Probios DFM supplements contain bacteria of proven efficacy in numbers capable of remaining viable during manufacturing and storage. Additionally, every guaranteed bacterium (expressed in CFUs or Colony Forming Units) will be available to the animal upon use all the way to the expiration date of the product. Vets Plus, Inc. is the exclusive manufacturer of Probios microbial products in the U.S. These products are manufactured in an ISO 9001:2008 certified facility following the guidelines of all top regulatory agencies. For questions about probiotics or Probios products call Vets Plus at

4 The ABCs of DFMs (Direct-fed microbials) What are DFMs? Direct-fed microbials are also known as probiotics. The word probiotic literally means for life and is the opposite of the word antibiotic. Probiotics are good bacteria that can help boost the levels of beneficial bacteria in the gut, whereas antibiotics attack and kill infections and unwanted bacteria. For animals, probiotics are more commonly referred to as direct-fed microbials, or DFMs. DFMs support overall health DFMs help maintain intestinal balance, overall health and performance by: Helping maintain natural immunity Helping maintain ph in the gut Helping maintain nutrient absorption Helping maintain gut microfloral balance Billions of bacteria Every animal with a digestive system, including us, has bacteria in their digestive system. Without bacteria an animal could not digest food. Animals have an extremely complex collection of about 100 trillion microorganisms in their entire digestive tract. The intestine of animals contains billions of bacteria, some of which are beneficial (good bacteria) and some which are pathogenic (bad bacteria). The importance of good bacterial balance Under certain conditions, such as stress, the natural balance of beneficial bacteria in the digestive system is disrupted. The number of pathogens increases while the number of beneficial organisms decreases, causing digestive upsets including diarrhea, constipation and discomfort. In animals, DFMs may help restore the normal microbial balance in the gut and overall health of the animal. Use of DFMs at birth Newborn animals do not have bacteria in their intestine. The intestine rapidly becomes colonized by natural means from the mother and the environment. Studies have shown providing DFMs to an animal at birth plays an important role in the growth and health of animals.

5 Swine, Sheep, Goats and Poultry Product Swine Nursery Oral Swine Suspension CHR oz bottle, 24 per case LAB*... not less than 5 Million CFU**/ml 2 ml (one full pump) at birth Dispersible Powder CHR g canister, 12 per case CHR lb canister, 6 per case CHR lb pail 2g / head / day Feed Granules CHR lb canister, 6 per case CHR lb bag 1/2 oz. Oral Boluses for Ruminants CHR ct jar 1/2 oz (14g each), 12 per case LAB*... not less than 98 Million CFU**/bolus 1/4 oz. Oral Boluses for Ruminants CHR ct jar 1/4 oz (7g each), 12 per case LAB*... not less than 49 Million CFU**/bolus * Lactic Acid Bacteria (LAB): Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum ** Colony Forming Units (CFU) Swine Starter / Grower Sows Sheep / Goats Poultry 5g / head / day 5g / head / day 5g / head / day in milk replacer Under 1 lb - 1/4 tsp daily 1-10 lbs - 1/2 tsp daily Over 10 lbs - 1 tsp daily 2g / head / day in ration 5g / head / day two weeks prior to farrowing and during lactation 5g / head / day in starter ration 1/2 bolus

6 Beef and Dairy Cows Incoming Product Newborns Calves Cows Hospital Feedlot / Stockers Bovine One Oral Gel CHR g tube, 24 per case CHR g tube, 72 per case 5g at birth Under 400 lbs - 10g Over 400 lbs - 15g 30g at freshening Under 400 lbs - 10g Over 400 lbs - 15g 15g first and last day of therapy MAX Oral Gel CHR g tube, 24 per case CHR g tube, 72 per case LAB*... not less than 1.5 Billion CFU**/g Vitamin A ,000 IU Vitamin D ,000 IU d-alpha-tocopherol Acetate (Natural Source Vitamin E) IU Vitamin B mcg d-pantothenic Acid mg Thiamine mg Folic Acid...50 mg Ascorbic Acid (Vitamin C)...25 mg 5g at birth Under 400 lbs - 10g Over 400 lbs - 15g 30g at freshening Under 400 lbs - 10g Over 400 lbs - 15g 15g first and last day of therapy Bovine One Oral Gel Plus Natural E CHR g tube, 24 per case CHR g tube, 72 per case d-alpha-tocopherol Acetate (Natural Source Vitamin E) IU/g 5g at birth Under 400 lbs - 10g Over 400 lbs - 15g 30g at freshening Under 400 lbs - 10g Over 400 lbs - 15g 15g first and last day of therapy 1/2 oz. Oral Boluses for Ruminants CHR ct jar 1/2 oz (14g each), 12 per case LAB*... not less than 98 Million CFU**/per bolus Under 400 lbs - 1/2 bolus Over 400 lbs - 2 bolus at freshening Under 400 lbs - 1/2 bolus Over 400 lbs - Under 400 lbs - 1/2 bolus Over 400 lbs - 1/4 oz. Oral Boluses for Ruminants CHR ct jar 1/4 oz (7g each), 12 per case LAB*... not less than 49 Million CFU**/bolus at birth Under 400 lbs - Over 400 lbs - 2 bolus 4 bolus at freshening Under 400 lbs - Over 400 lbs - 2 bolus Under 400 lbs - Over 400 lbs - 2 bolus Low Intake / Environmental Stress

7 Dispersible Powder CHR g canister, 12 per case CHR lb canister, 6 per case CHR lb pail LAB*... not less than 10 Million CFU**/g Feed Granules CHR lb canister, 6 per case CHR lb bag Applicator All-metal construction for durability and ease of use. One full squeeze of the handle delivers 15g of Probios needed in large animal applications. There is also a movable pin to adjust the dose to 5g and 10g for other applications. It also works with other standard 300g gel or paste tubes. * Lactic Acid Bacteria (LAB): Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum ** Colony Forming Units (CFU) 5g / head / day with fluids 5g / head / day with fluids 10-15g / head / day in ration 30g / head / day for 3 days

8 Equine Product Foals Horse / Adult Hospital Training / Competitions Equine One Oral Gel CHR g tube, 24 per case 10g at birth and day four 15g at foaling, following therapy, during training, transport, or digestive upset 15g first and last day of antibiotic therapy 15g before and after competition MAX Oral Gel CHR g tube, 24 per case CHR g tube, 72 per case LAB*...not less than 1.5 Billion CFU**/g Vitamin A...260,000 IU Vitamin D ,000 IU d-alpha-tocopherol Acetate (Natural Source Vitamin E ) IU Vitamin B mcg Pantothenic Acid mg Thiamine mg Folic Acid...50 mg Ascorbic Acid (Vitamin C)...25 mg 10g at birth 15g / day Dispersible Powder CHR g canister, 12 per case CHR lb canister, 6 per case CHR lb pail 5g / head / day 10-15g / head / day in ration 10-15g / head / day in ration Feed Granules CHR lb canister, 6 per case CHR lb bag 5g / head / day in ration 15g / head / day in ration 10-15g / head / day in ration

9 Horse Treats (Apple Flavored) CHR-750/6-1 lb pouch, 6 per case (Digestion Support) CHR-752/6-1 lb pouch, 6 per case (Joint Support) Total Live Bacteria Count...not less than 5 Million CFU**/ 6g treat Horse Soft Chews (Apple Flavored) CHR lb pouch, 6 per case Total Live Bacteria Count...not less than 150 Million CFU**/10g chew * Lactic Acid Bacteria (LAB): Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum ** Colony Forming Units (CFU) Bacillus subtilis and Bacillus licheniformis 3-6 treats / day 1-2 chews / day

10 Dog and Cat Post-Weaning Product Newborns / Puppies Dogs / Adult Kittens Cats / Adult Dogs / Cats Dispersible Powder CHR g canister, 12 per case CHR lb canister, 6 per case CHR lb pail LAB*... not less than 10 Million CFU**/g Under 1 lb 1-10 lbs 1/2 tsp / day Over 10 lbs 1 tsp / day Under 1 lb 1-10 lbs 1/2 tsp / day Over 10 lbs 1 tsp / day Under 1 lb 1-10 lbs 1/2 tsp / day Over 10 lbs 1 tsp / day 5g (1 tsp) in food or water Probiocin Oral Gel for Pets CHR g tube, 72 per case LAB*... not less than 10 Million CFU**/g 1g at birth 1g per 10 lbs of body weight following therapy, during training, transport, or digestive upset 5g / head / day two weeks prior to farrowing and during lactation 5g / head / day in starter ration Daily Digestive Dog Tabs (Liver Flavored) CHR ct bottle, 6 per case CHR ct bottle, 6 per case LAB*...not less than 98 Million CFU**/tablet 1 tablet per day 1 tablet per 20 lbs of body weight Dog Treats (Peanut Butter Flavored) CHR-950/6-1 lb pouch, 6 per case (Digestion Support) CHR-951/6-1 lb pouch, 6 per case (Joint Support) Total Live Microbial Count... not less than 5 Million CFU**/ 2.5g treat 3-6 treats per day Soft Chews for Large and Small Dogs (Liver Flavored) CHR g jar, 6 per case (Small Dog) Total Live Bacteria Count... not less than 5 Million CFU**/ 1g chew Small Dogs: 2 chews per 10 lbs of body weight daily CHR g jar, 6 per case (Medium & Large Dog) Total Live Bacteria Count... not less than 20 Million CFU**/ 4g chew Medium & Large Dogs: 1-3 chews per 50 lbs of body weight daily

11 Small Animals and Reptiles Product Guinea Pigs / Rabbits Dispersible Powder CHR g canister, 12 per case CHR lb canister, 6 per case CHR lb pail LAB*... not less than 10 Million CFU**/g Probiocin Oral Gel for Pets CHR g tube, 72 per case LAB*... not less than 10 Million CFU**/g 1g at birth, following antibiotic therapy, or digestive upset * Lactic Acid Bacteria (LAB): Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum ** Colony Forming Units (CFU) Bacillus subtilis, Bacillus licheniformis Ferrets / Hamsters / Gerbils Under 1 lb 1-10 lbs 1/2 tsp / day Over 10 lbs 1 tsp / day Birds Under 1 lb 1-10 lbs 1/2 tsp / day Over 10 lbs 1 tsp / day Rodents / Reptiles 1g per 10 lbs of body weight following therapy or digestive upset

12 06/14

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