CoQ10. The Metabolic Antioxidant

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1 CoQ10 The Metabolic Antioxidant

2 The many facets of coenzyme Q 10 as a metabolic cofactor, antioxidant and membrane stabilizer render it one of the most versatile, evidence-based tools in the holistic, integrative and allopathic repertoire of nutritional supplements. As an isoprenoid quinone redox cofactor, its rare physiochemical properties lend a functional profile that no vitamin or essential nutrient can recapitulate. The functional spectrum of CoQ 10 traverses the most salient determinants of good health, including metabolism, neuroprotection and cardiovascular homeostasis. Over 50 years since its initial discovery, cross-disciplinary research in molecular medicine continues to unveil important roles that stem from multifocal bioenergetic and genomic targets. Kelly C. Heim, Ph.D. Committed to CoQ 10 Excellence Japanese-sourced CoQ 10 only Natural, fermented CoQ 10 Trans-isomer only; No cis-isomer impurities Committed to CoQ 10 Science Q-Gel, Ubiquinol and Sustained Release forms of CoQ 10 Product Sponsor: A Randomized, Controlled Trial of Two Dosage Forms of CoQ 10 for the Improvement of Statin-Related Myalgia and Muscle Pain. 2 TO ORDER CALL Secure online ing and information at

3 CoQ10 CoQ mg each vegetable capsule contains v 00 coenzyme Q mg (hypo-allergenic plant fiber may be added to complete capsule volume requirement) CoQ mg CQ56 CoQ mg each vegetable capsule contains v 0 coenzyme Q mg CoQ mg CQ26 CoQ mg each vegetable capsule contains v 3 coenzyme Q mg 2 4 capsules per day, in divided doses, with meals. CoQ mg 120 CQ31 See our multivitamins with CoQ 10 UltraNutrient Athletic Nutrients PureOne Nutrients UltraPure Pack Men s Pure Pack Women s Pure Pack Athletic Pure Pack CoQ mg each vegetable capsule contains v 0 coenzyme Q mg CoQ mg 120 CQ11 CQ16 30 CQ13 CoQ 10 mg each vegetable capsule contains v 3 coenzyme Q mg CoQ 10 mg 250 CQ CQ61 CQ66 Independent Third Party Testing *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 3

4 Cardiokinase w/coq10 Fibrinolytic enzyme produced using new nattokinase fermentation process* May have over 10% greater lymphatic absorption and 20% greater effectiveness than other nattokinases* Unique CoQ 10 /ubiquinol complex for enhanced circulatory support* Kaneka QH is a trademark of Kaneka Corporation. two vegetable capsules contain 3 Cardiokinase (nattokinase strain N) (25 i.u.) (from non-gmo soy) mg coenzyme Q mg ubiquinol (Kaneka QH active antioxidant form of coenzyme Q 10 )...40 mg ascorbyl palmitate (fat-soluble vitamin C)...10 mg other ingredients: gelatin beadlet, cornstarch, mixed tocopherols Take 1 capsule in the morning and 1 capsule in the evening, 1/2 hour before meals. Cardiokinase w/coq 10 CKQ6 CoQ10 l-carnitine fumarate Dual support for heart muscle function and oxygenation* Supports skeletal muscle energy and moderates lactate levels* DuraCarn is a registered trademark of Sigma-Tau HealthScience, Inc. U.S. Patent pending. The combination of l-carnitine and CoQ 10 is produced under a non-exclusive license from SIGMA-TAU/BIOSINT, U.S. patent number 4,599,232. each vegetable capsule contains v 00 l-carnitine (free-form) mg (from 586 mg l-carnitine fumarate) coenzyme Q mg 2 4 capsules per day, in divided doses, with meals. CoQ 10 l-carnitine fumarate 120 CQF1 RiboCarnitine-Q 10 Patented, synergistic carnitine combination Supports strenuous exercise via muscle adaptation; helps lessen fatigue* Enhances cardiac function with CoQ 10 for added vascular and lipid support* Features ribose for both energy and cardiac support properties* GlycoCarn is a registered trademark of Sigma-Tau HealthScience and is manufactured under U.S. Patent 6,703,042 and European Patent 1,202,956. The combination of GlycoCarn GPLC and CoQ 10 is patented by Sigma-Tau Industries under U.S. Patent 6,814,972. The combination of GlycoCarn GPLC, l-carnitine and acetyl-l-carnitine is patented under U.S. Patent 6,245, 378. Use of d-ribose by Pure Encapsulations is authorized by Bioenergy, Inc. under U.S. Patents 4,5,644; 4,719, 201. three vegetable capsules contain v 00 d-ribose...1,000 mg l-carnitine (free-form) (from l-carnitine fumarate) mg GlycoCarn GPLC (glycine propionyl-l-carnitine HCl) mg acetyl-l-carnitine (from acetyl-l-carnitine HCl) mg coenzyme Q mg ascorbyl palmitate (fat-soluble vitamin C)... mg other ingredients: silica 3 6 capsules per day, in divided doses, with meals. RiboCarnitine-Q RCQ1 4 TO ORDER CALL Secure online ing and information at

5 Q-Gel (Hydrosoluble CoQ10) Water and oil soluble CoQ10 Provides enhanced bioavailability in more body tissues* Manufactured via the patented Bio Solv process Q-Gel and Bio Solv are registered trademarks of Tishcon Corp. Hydrosoluble is a trademark of Tishcon Corp. Manufactured under one or more of the following U.S.Patents: 6,056,971; 6,300,377; and 6,740,338. Q-Gel 100 (Hydrosoluble CoQ10) 22 sg vitamin E (d-alpha tocopheryl acetate) i.u. coenzyme Q mg other ingredients: gelatin, sorbitol, glycerin, purified water, annatto seed extract (natural color) in a patented Bio Solv base (polysorbate 80, hydroxylated soy lecithin, medium chain triglycerides). Q-Gel 100 (Hydrosoluble CoQ10) QG16 Q-Gel (Hydrosoluble CoQ10) MEAN PLASMA CoQ10 VALUES (µg/ml) 4-Week Q-Gel vs. Reference Study Q-Gel Reference DAYS OF SUPPLEMENTATION Mean plasma CoQ10 values during four weeks of supplementation with CoQ10 suspension in oil (softgel capsules) as the reference and Q-Gel (softgel capsules). Q-Gel significantly differs from CoQ10 suspension in oil at 28 days. p= sg vitamin E (d-alpha tocopheryl acetate) i.u. coenzyme Q10... mg other ingredients: gelatin, glycerin, sorbitol, purified water, titanium dioxide, annatto seed extract (natural color) in a patented Bio Solv base (polysorbate 80, soy lecithin, triacetin, medium chain triglycerides). Q-Gel (Hydrosoluble CoQ10) QG66 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 5

6 Ubiquinol 4-Week Multiple Dose Kaneka QH Study TM Active antioxidant form of CoQ10 Activated by presence of two hydrogen atoms Enhanced potential to increase serum levels* Preferred form for individuals over 40 or individuals experiencing increased oxidative stress* Kaneka QH is a trademark of Kaneka Corporation. The use of ascorbyl palmitate in the formulation is covered by U.S. Patent 6,740,338. Ubiquinol-QH 200 mg 16 sg ubiquinol (Kaneka QH active antioxidant form of coenzyme Q10) mg other ingredients: medium chain triglycerides, gelatin, glycerin, ascorbyl palmitate, purified water, beeswax, soy lecithin, annatto extract. Take 1 softgel per day with a meal, or as directed by a health professional. Ubiquinol-QH 200 mg 10 Plasma ubiquinol conc. (µg/ml) Developed after 10 years of research by leading manufacturer Kaneka Corporation 90 mg 150 mg Treatment sg ubiquinol (Kaneka QH active antioxidant form of coenzyme Q10) mg other ingredients: medium chain triglycerides, gelatin, glycerin, ascorbyl palmitate, purified water, beeswax, soy lecithin, annatto extract. Take 1 2 softgels per day with meals. Ubiquinol-QH 100 mg UQ16 Ubiquinol-QH 50 mg 10 sg ubiquinol (Kaneka QH active antioxidant form of coenzyme Q10) mg other ingredients: medium chain triglycerides, gelatin, glycerin, ascorbyl palmitate, purified water, beeswax, soy lecithin, annatto extract. Take 1 2 softgels per day with meals. 6 Ubiquinol-QH 50 mg UQ56 TO ORDER CALL Morning trough concentrations of ubiquinol in plasma during 4-week multiple oral administration of ubiquinol and 2 weeks after completion of the treatment in healthy volunteers. Each point represents the mean +/-SEM of 20 subjects (90 mg and 150 mg) or 19 subjects (300 mg). UQ26 35 Time after first dose (days) Ubiquinol-QH 100 mg 300 mg Secure online ing and information at

7 SR-CoQ10 with PQQ SR-CoQ10 Absorption in Human Volunteers 24-hour sustained release MicroActive CoQ10 Combined with BioPQQ, a B vitamin-like cofactor* For enhanced cardiac, neural and cognitive health* Convenient, once-daily dosing two vegetable capsules contain v 0 coenzyme Q10 (from MicroActive Q10-cyclodextrin complex) mg BioPQQ pyrroloquinoline quinone disodium salt...20 mg other ingredients: potato starch, vegetable capsule 2 capsules per day, in the morning, with a meal. SR-CoQ10 with PQQ CQP6 Figure 1. Comparison of the mean plasma CoQ10 concentrations after a single oral dose of either SR-CoQ10 or solubilized softgel CoQ10. Mitochondrial, Cognitive and Cardiovascular Mechanisms of CoQ10 and PQQ *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 7

8 EPA/DHA-CoQ10 Features ultra-pure, molecularly distilled fish oil Provides omega-3/coq 10 combination for enhanced heart health* 20 sg calories calories from fat total fat...1 g fish oil concentrate (anchovies, sardines) mg providing: EPA (eicosapentaenoic acid) mg DHA (docosahexaenoic acid) mg coenzyme Q mg vitamin E (d-alpha-tocopherol) i.u. other ingredients: annatto extract, beeswax, gelatin capsule 1 or more capsules per day, with meals. EPA/DHA-CoQ EDQ1 EPA/DHA-CoQ10 liquid Convenient, natural orange flavored liquid each teaspoon (5 ml/0.18 fl oz) provides calories calories from fat total fat g saturated fat...1 g cholesterol...25 mg fish oil concentrate (anchovies, sardines)...4,295 mg providing (typical): EPA (eicosapentaenoic acid) mg DHA (docosahexaenoic acid) mg coenzyme Q mg other ingredients: natural orange and citrus flavors, proprietary antioxidant blend (natural vitamin E, rosemary extract and ascorbyl palmitate) This formula requires refrigeration after opening. Best when consumed within 90 days after opening. Contents may appear cloudy when refrigerated. Contents may precipitate; shake well. 1 3 teaspoons per day, with meals. EPA/DHA-CoQ 10 liquid (orange flavor) 200 ml (7 fl oz) EDO2 Pure Encapsulations, Inc., 490 Boston Post Road, Sudbury, Massachusetts USA info@pureencapsulations.com T: F:

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