THE WORLD CAROTENOIDS MARKET

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1 Science Market Regulation UBIC 2015 Marketing development Strategy consulting Partnership searches Information systems

2 UBIC Technical & Competitive Scanning Regulations Manufacturers This comprehensive report is based on in-depth interviews with food companies completed by a desk review. It provides for DECISION MAKERS a global understanding of the sector as well as an outlook on its future. MARKET ANALYSIS New trends and perspectives Usage of ingredient volumes-value Manufacturers profiles Users opinion Regulation New patents MARKET COVERED America Asia Europe Oceania APPLICATIONS Food & Beverages Industry Feed industry Dietary Supplements Pharmaceutical products Cosmetics INGREDIENTS COVERED Beta-carotene Lycopene Lutein Astaxanthin Canthaxanthin

3 O B J E C T I V E S M A R K E T Food consumption trends and expectations Consumer market trends by food segments Prospective M A N U F A T U R E R S Food industry orientations Applications in food segments Consumption R E S E A R C H New researches and new developments INTRODUCTION Carotenoids are a class of natural fat-soluble pigments responsible for the red, orange and, yellow colors of plant leaves, fruits, and flowers, as well as for the color of feathers, crustacean shells, fish flesh and skin, etc. In nature, over 620 carotenoids have been identified and characterized, but it seems that only up to 50 dietary carotenoids from fruits and vegetables may be absorbed and metabolized by human. Apo-carotenic ester Classification Capsanthin Capsorubin Total Xanthophylls Astaxanthin Canthaxanthin Carotenoids Xanthophylls Carotenes Beta-carotene Zeaxanthin Lutein Natural carotenoids have similar molecular structure than synthetics, but natural carotenoids differ on molecular structure providing major benefits to health. Industrial production of natural carotenoids can be carried out through to: -Biotechnological processes using filamentous fungi, yeasts, bacteria or microalgae, -Solid-liquid extraction from plants. Carotenoids are important factors in human health. The essential role of beta-carotene and others as the main dietary source of vitamin A has been known for many years. More recently, carotenoids have been considered as powerful antioxidant. Protective effects of carotenoids against serious disorders such as cancer, heart disease and degenerative eye disease have been recognized and have stimulated intensive research into the role of carotenoids as antioxidants and as regulators of the immune response system. PATENTS Percentage of carotenoids US patents per sector Applications for humans Applications in feed Production by algae Production by bacteria Production by fungi Production by plants Methods of extraction Chemical synthesis Enzyme/ DNA sequences

4 BETA-CAROTENE O B J E C T I V E S M A R K E T Food consumption trends and expectations Consumer market trends by food segments Prospective M A N U F A T U R E R S Food industry orientations Applications in food segments Consumption R E S E A R C H New researches and new developments GENERALITIES Beta-carotene is one of the most common carotenoids and is used widely in the food industry as a food coloring. Carotenes can be extracted from a number of sources including algae, carrot and palm oil, or produced by the fermentation of microorganisms. Beta-carotene holds unique properties as a colorant, physiological antioxidant and provitamin A. This versatility means that it is used across many different segments, which include food, feed, supplements and cosmetics. Each segment demands different properties and stability of the beta-carotene formulations, which has led to the development of three major product groups: -Oil suspensions -Powders -Beadlets -Emulsions Natural β-carotene has better physical properties than the synthetic entity in the presence of two isomers, the trans isomer and the 9-cis isomer. Synthetic b-carotene contains only the fully trans isomer, which has lower liposolubility and antioxidant activity than the 9-cis isomer, which is found exclusively in the natural environment. Segment Human nutrition Food and drinks APPLICATION SEGMENTS Main applications Butter, Margarine,Fats, Oils, Cheese, Soft drinks, Ice cream, Yoghurts, Desserts, Flour and sugar confectionery, Jellies, Preserves, Dressings, Meat products ( ) - Food supplements and Nutraceuticals Food Ingredients To provide color Anti-oxidant effects ( ) Animal nutrition Animal Feed - Help maintain optimal pet health ( ) Pet food Fish & crustaceans - Achieve bright coloration in fish Pharmaceutics and Cosmetics it is used to treat or to lower risk of several diseases :, ( ) Skin and hear care products Beta-carotene used as colorant Color Color pigment Shade Stability of Color Carotenes E106a β-carotene Mixed Carotenes Orange Heat Stable Light sensitive Oxygen sensitive Acid stable (ph 2-8)

5 O B J E C T I V E S M A R K E T OUTLOOK OF THE MARKET Carotenoids market value by region ($ mio)-2014 Carotenoids market breakdown by type (%)-2014 Food consumption trends and expectations Consumer market trends by food segments Others Beta-carotene Lycopene Canthaxanthin Astaxanthin Lutein Prospective M A N U F A T U R E R S Food industry orientations Applications in food segments Consumption R E S E A R C H New researches and new developments Beta-carotene represents the largest product market supported by extensive use as a coloring agent in various applications including food, pharmaceuticals and cosmeceuticals. Algae-derived beta-carotene is forecast to witness robust demand in the food and supplements end-use sector. Carotenoids Main suppliers DSM (NL) BASF (Dk) LycoRed DIVIS LABORATORIES (India) CAROTECH (India) ZMC (China) ALLIED BIOTECH (TW) ( ) BETA-CAROTENE WORLD MARKET ESTIMATIONS, 2014 TOTAL Synthetic Beta-carotene Natural Beta-carotene Betacarotene production Tons Mio $ Tons Mio $ Tons Mio $ Algae Fermentation Palmoil Mio $ Mio $ Mio $

6 CAROTENOIDS Chemical structure and classification Carotenoids and health Carotenoids Manufacture Regulation Patents Researches The State Of Consumer Awareness BETA CAROTENE Beta-carotene Characteristics Natural VS synthetic beta-carotene Applications Beta-Carotene Dosing, Safety and Interaction Generalities Leading Applications Carotenoids market by Region Carotenoids market by Type Carotenoids Key Players THE WORLD COLORING AGENT MARKET THE WORLD BETA-CAROTENE MARKET Beta-Carotene Global Market Industrial players Beta-carotene Market Price SUPPLIERS- MAIN PLAYERS DSM Nutritional Products BASF Cognis Deutschland GmbH & Co.KG Zhejiang NHU Co.,Ltd Zhejiang Medicine Co., Ltd. Carotech Sdn Bhd Allied Biotech Corp. Ltd Cyanotech Corp Divis Laboratories Naturex SA TABLE OF CONTENT VIDYA HERBS Pvt. Ltd D.D.Williamson & Co., Inc. Brenntag North America, Inc. Glanbia Nutritionals Na Inc. Chr. Hansen LycoRed FMC BioPolymer Dynadis SARL OTHER SUPPLIERS Bio-gen Extracts Biotrend Sasol Uralbiopharm Biosynergy GMBH Proalgen Biotech Ltd Xiamen Shengbao Trading Co., Ltd Wuxi Gorunjie Natural-Pharma Co., Ltd Wuhan Yuancheng Gongchuang Technology Co.,Ltd Gemsen International Co., Ltd Qingdao Sunrise Biotechnology Co., Ltd. Anhui Sino-Maple Import & Export Co., Ltd DISTRIBUTORS Fiske Food Ingredients Whole Food Market Nature's Market SOME MAIN USERS OF BETACAROTENE Stratum Nutrition Kellogg s Company Unilever Slim-fast Foods (UNILEVER-KAINOS) Abbott Nutritionals Kraft Canada Inc. Nestlé S.A

7 LISTE OF TABLES Table 1. Chemical category of different food grade biocolorants. Table 2. Carotenoids used in food and produced at industrial scale Table 3: Concentration of Carotenoids in human milk (nmol/g milk fat) Table 4: Concentration of carotenoids in human tissues (nmol/g) Table 5. Health properties of beta-carotene, Lutein and Lycopene Table 6. Carotenoid Sources of Commercial Importance Table 7. Beta-Carotene composition Table 8. Beta-Carotene produced by fermentation Table 9. Microorganism sources of Beta-carotene Table 10: Commercial sources of Beta-carotene Table 11. Main applications of Beta-Carotene Table 12: Beta-carotene s application by delivery system Table 13: Main Applications of microalgae due to their carotenoids content Table 14: Carotenoids market breakdown by value ($mio) Table 15: The World Food Coloring Agent Market Evolution and Estimations 2014 Table 16: The world natural coloring market for food Table 17: Beta-carotene prices Table 18: BETA-CAROTENE WORLD MARKET ESTIMATIONS, 2014 Table 19: Beta-carotene market growth evolution 2014 Table 20. Main application fields of beta-carotene Table 21. Market breakdown of Colorant- Carotenoids and Beta carotene by region LISTE OF FIGURES Figure 1: General structure of Carotenoids Figure 2: Chemical structure of Beta-carotene, astaxanthin and lutein Figure 3. Scientific evidence of carotenoids Figure 4: Percentage of carotenoids patents per type and per sector. Figure 5: comparative Beta-carotene Beadlets stability (gelatin vs starch) Figure 6: comparative Beta-carotene Beadlets stability in tablet (gelatin vs starch) Figure 7. The trans and cis configuration of beta-carotene Figure 8: Carotenoids global Market value estimations and forecast Figure 9: Carotenoids market by segment 2014 Figure 10: Carotenoids market value breakdown by application 2014 Figure 11: Carotenoids market breakdown by region 2014 Figure 12: Geographical partition of the Carotenoids market value in $ mio (2014) Figure 13 : Carotenoids market breakdown by type (%) Figure 14 World Food colorants market by regions, 2013 Figure 15: Beta-carotene global market estimation by application (US$ mio) Figure 16: Beta-carotene market value estimation (USD Mio) Figure 17: beta-carotene market by type on a value basis (2014) Figure 18: Natural beta-carotene market value by sources (2014) Figure 19: Estimated beta-carotene global market value by category (2014) Figure 17 : Estimations about the USA imports value of beta-carotene in 2014

8 ORDER FORM Sections Up-date 2015 Complete study All sections 2,390 Market Analysis 1,690 The World Carotenoids Market 890 The World Beta-carotene Market 570 One section The World Coloring Agent Market 250 Suppliers 700 Distributors Some Main Users Study purchase includes one year update available on-line on UBIC s Extranet Assistance is also available for specific questions COMPANY Name Position Date Signature

9 Partners UBIC USA UBIC IRELAND UBIC EUROPE Russia UBIC FRANCE UBIC CHINA UBIC JAPAN Mexico UBIC MENA India Argentina UBIC BRAZIL UBIC INDONESIA

The Chemical Synthesis Route (Continued) FIGURE 2 SYNTHESIS OF CAROTENOIDS: FLOW CHART FOR PREPARATION OF BETA-IONONE FIGURE 3 SYNTHESIS

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