Toxicology An Introduction. John Duffus The Edinburgh Centre for Toxicology
|
|
- Theodora Russell
- 6 years ago
- Views:
Transcription
1 Toxicology An Introduction John Duffus The Edinburgh Centre for Toxicology
2 General considerations Toxicology is the science which lets us know how substances can harm life by physico-chemical reactions with living cells All substances, whether synthetic or natural, can cause harm to people, animals, plants, micro-organisms, and their environment
3 General considerations There are naturally occurring substances which are as poisonous as or more poisonous than the most toxic synthetic chemicals For example - ricin, Clostridium botulinum toxin, saxitoxin
4 Toxicity and dose The toxicity (poisonous nature) of any substance is inversely related to the amount (dose) required to cause harm The more that is required, the lower the toxicity But - all substances are toxic at a high enough dose
5 Toxicity and dose Substances that can cause harm following exposure to very small amounts, sometimes no more than a few molecules, are said to be extremely toxic Substances that require exposure to many grams before harm results are said to have low toxicity
6 Toxicity and Dose Even essential nutrients become toxic if the amount ingested is above a certain acceptable dose Some substances such as oxygen are toxic (harmful) at the dose which is essential for life! We are protected by anti-oxidants Oxygen is toxic at all levels to obligate anaerobes (toxicity classification?)
7 Dose-effect curves No-Threshold Stochastic Toxicant Increasing adverse effect Essential Nutrient Threshold Nonstochastic Toxicant NOAEL 0 Increasing Dose Threshold
8 What is a poison? 500 years ago, a physician called Paracelsus wrote the following fundamental rule of toxicology: Only the dose required makes the difference between a cure and a poison Note: Paracelsus is the name given to Theophrastus Phillippus Aureolus Bombastus von Hohenheim
9 What is a poison? Water? - essential for life but people have died from drinking too much pure water, washing out essential salts such as sodium chloride and potassium chloride Fresh water fish rarely survive in salt water or salt water fish in fresh water and so both could be classified as poisons
10 What is a poison? Vitamin A? - essential for human health; it is fairly easy to exceed the required dose and people have died from eating too much It may also cause developmental abnormalities in babies if their mothers consume too much while carrying them during pregnancy
11 What is a poison? Oxygen? - essential for aerobic life but destroys essential molecules by oxidation; protective mechanisms involving compounds such as vitamin C, vitamin E, and glutathione have evolved Reactive oxygen species (ROS) have been implicated in mutagenesis and carcinogenesis
12 Natural and synthetic chemicals Aflatoxin, from the fungus Aspergillus flavus, is one the most potent carcinogens known, causing liver cancer in people, birds and fish after eating food made from contaminated cereals such as rice
13 Natural and synthetic chemicals The distinction between naturally occurring substances and synthetic substances is of little value in considering toxicity Pure natural vitamin C and pure synthetic vitamin C are identical molecules and equally good for people
14 Movement through the environment Substances in the environment, whether toxic or not, may enter living organisms directly - by inhalation (lungs or gills), ingestion, by skin contact, through wounds, or through the eyes Or indirectly from food or through the environmental media - air, soil, sediments, or water
15 Routes of human exposure from the environment Each route of exposure must be considered separately although the effects may be interactive
16 Routes of direct human exposure Eyes Respiration through nose and mouth Ears Ingestion through mouth* Absorption through skin, wounds Exposure of baby in the womb through the placenta *Do not forget exposure of babies through mother s s milk
17 Different routes - different effects? Different routes of exposure may cause different effects from the same substance Sometimes only one route of exposure is harmful For example, organophosphate pesticides are highly toxic through the lungs but break down in the stomach
18 Exposure of the child in the womb and babies The developing child in the womb may be harmed by substances in the mother s bloodstream which can pass across the placenta into the baby s blood circulation An example is methylmercury chloride, found naturally in tuna and swordfish, which can kill a baby in the womb at levels which do not harm the mother
19 Exposure of the child during breast feeding The breast feeding child may be harmed by substances in mother s milk Particularly dangerous in this respect are persistent fat-soluble compounds such as organochlorine pesticides which can accumulate in the breast; they are included in the United Nations list of persistent organic pollutants (POPS), banned in many countries
20 Nanoparticles Particles smaller than 2.5 µm and particularly nanoparticles, previously called ultrafines (<100 nm), may lodge permanently in the alveoli and cause chronic problems; nanoparticles may move through cell junctions into the body and affect the heart
21 Phases of poisoning Exposure (already discussed) is the first phase The toxicokinetic phase covers uptake to excretion The toxicodynamic phase covers all aspects of the way in which a substance causes harm once it reaches its target in the body
22 Phases of poisoning Chemical Exposure Phase Toxicokinetic Phase Toxicodynamic Phase Potentially Toxic Substances Derivatives or Formulation Absorption Biotransformation Circulation Tissue Binding Toxicity Initiator Reaction at Key Sites (receptors) Toxicity Circulation Excretion
23 Metabolism and excretion of fat soluble (lipophilic) substances Fat Soluble Substances Highly Fat Soluble Substances Binding to blood cells, albumin, lipoproteins, lymph cells, lymph proteins Phase 1 and Phase 2 Reactions Water soluble products Blood Circulation Excretion in Urine Excretion in Bile to the Gut Blood Circulation Reabsorption from Gut Physical localization, accumulation in fatty tissue Hydrolysis in Gut Excretion in Faeces Breathed Out in Air Milk, sweat and other secretions, including genital secretions
24 Acute toxicity Toxicity resulting from short exposure is called acute toxicity Acute Toxicity Duffus & Worth, IUPAC 39
25 Chronic toxicity Toxicity resulting from long term exposure Chronic Toxicity Duffus & Worth, IUPAC 40
26 Chronic toxicity follows accumulation of toxicants or Accumulation by storage in: effects Fat DDT, PCBs, tetraethyl lead etc Bone Lead ions, calcium ions, strontium ions etc Liver and kidney-bind and trap both organic and inorganic toxicants Plasma proteins- especially albumin, bind both organics and inorganics; competition for binding may displace a large dose causing toxicity
27 Important aspects of chronic toxicity Chronic toxicity includes the production of cancer (carcinogenicity) and possibly senile dementia and other diseases of old age Note the special problem of brain cells where normal decrease through life may be accelerated by exposure to toxicants
28 Exposure to mixtures Living organisms are exposed to mixtures of potentially harmful substances There are four types of effects chemicals can have on each other: exposure to two or more substances simultaneously may produce effects that are independent, additive, synergistic, or antagonistic
29 Effects of exposure to mixtures Independent substances do not interfere with each other or enhance each other s effect on simultaneous exposure Additive - have the same effect independently and any combined exposure produces a total effect equal to the sum of the effects of separate exposure to each substance
30 Effects of exposure to mixtures Synergistic substances have the same effect or different effects but the final effect observed is greater than the sum of the effects of separate exposure to each substance Antagonistic - effect of one substance counteracts the adverse effect of another; exposure to the substances together has less effect than the sum of the effects of independent exposures
31 Chemical Speciation The chemical species of an element is the specific form in which it exists, defined as to isotopic composition, electronic or oxidation state, and/or complex or molecular structure Thus, organic chemistry is the study of the nature and properties of all the chemical species of carbon
32 Why is speciation important? Consider mercury. It can exist as the pure metal which is an electrically neutral volatile liquid The vapour is fat soluble, the liquid metal is neither fat soluble or water soluble It can also exist as Hg + or Hg 2+ ions that are sparingly soluble. However HgCl 2 in seawater is largely unionized and therefore fat soluble Methylmercury chloride is sparingly water soluble and very fat soluble
33 Why is speciation important? Mercury (continued) Fat soluble mercury vapour and mercuric chloride enter cells easily through the phospholipid membrane Liquid mercury is not absorbed by cells. Ionized mercurous chloride does not enter cells; unionized mercuric chloride does. Fat soluble methylmercury chloride enters cells readily
34 Why is speciation important? Mercury continued Fat-soluble mercury species, e.g. mercury vapour, fat-soluble unionized mercuric chloride, and fat-soluble methylmercury chloride are highly toxic Liquid mercury and ionized mercurous and mercuric salts have relatively low toxicity
35 The biological dimension - prokaryotes (e.g.bacteria) no nuclear membrane Tail Ribosomes Cell Membrane DNA Glycogen
36 The biological dimension eukaryotes, e.g., human cells, note the nuclear membrane
37 Toxicity targets in eukaryote Vacuole THE CELL S POWER PLANT ATP synthesis cells 37 Directs protein synthesis, regulates metabolism, reproduction. Contains chromatin, DNA Mitochondria Cytosol Ribosomes Nucleus Endoplasmic reticulum (rough) Synthesis of proteins for the cell and for export Lysosome Protein synthesis Endoplasmic reticulum (smooth) Detoxification. Production of lipids, carbohydrates Golgi apparatus 30 µm Microfilaments Plasmic membrane Waste treatment : Intracellular digestion Synthesizes carbohydrates which are packed with proteins for cellular use or export
38 Speciation and biology Cell membrane Cr(III) as [Cr(H 2 O) 6 OH] 2+ Cr(VI) as CrO 4 2- (chromate) Sulfate / phosphate active transport system Cytochrome P450 Cr(VI) as CrO 2- system 4 Cr (III / IV) Hypotheses (chromate) - species unknown Reactive Oxygen Species (ROS) Reacts with phosphate and sulfate metabolism enzymes, DNA, RNA and their polymerases? Nuclear membrane Mutations
39 The End Thank you very much for your attention
General Considerations
The Science of Chemical Safety Essential Toxicology - 1 General Considerations John Duffus & Howard Worth IUPAC Educators Resource Material IUPAC General Considerations Toxicology is the science which
More informationIndustrial Toxicology
Industrial Toxicology Learning Objectives Know the assumptions of the doseresponse and time-course curves Be able to define and label key points of a curve Know the difference between potency and efficacy
More informationUnit 2 Warm Ups. Equilibrium
Unit 2 Warm Ups Equilibrium 1. Cell wall 2. Mitochondria 3. Chloroplast 4. Vesicle 5. Vacuole 6. Rough Endoplasmic Reticulum 7. Smooth Endoplasmic Reticulum 8. Cytoskeleton 9. Lysosomes 10.Cell Membrane
More informationCELLS and TRANSPORT Student Packet SUMMARY CELL MEMBRANES ARE SELECTIVELY PERMEABLE DUE TO THEIR STRUCTURE Hydrophilic head
CELLS and TRANSPORT Student Packet SUMMARY CELL MEMBRANES ARE SELECTIVELY PERMEABLE DUE TO THEIR STRUCTURE Hydrophilic head Hydrophobic tail Hydrophobic regions of protein Hydrophilic regions of protein
More informationA Tour of the Cell Lecture 2, Part 1 Fall 2008
Cell Theory 1 A Tour of the Cell Lecture 2, Part 1 Fall 2008 Cells are the basic unit of structure and function The lowest level of structure that can perform all activities required for life Reproduction
More informationHuman Epithelial Cells
The Cell Human Epithelial Cells Plant Cells Cells have an internal structure Eukaryotic cells are organized Protective membrane around them that communicates with other cells Organelles have specific jobs
More information7-2 : Plasma Membrane and Cell Structures
7-2 : Plasma Membrane and Cell Structures Plasma Membrane of aveolar sac But first... Let s Review What is cell theory? Light microscopes vs. electron microscopes Prokaryotic vs. eukaryotic Basic Cell
More informationA Tour of the Cell. Ch. 7
A Tour of the Cell Ch. 7 Cell Theory O All organisms are composed of one or more cells. O The cell is the basic unit of structure and organization of organisms. O All cells come from preexisting cells.
More informationCells & Cell Organelles
Cells & Cell Organelles The Building Blocks of Life AP Biology 2008-2009 Types of cells bacteria cells Prokaryote - no organelles Eukaryotes - organelles animal cells plant cells Cell size comparison Animal
More informationENVIRONMENTAL TOXICOLOGY
ENVIRONMENTAL TOXICOLOGY Chapter 4 Toxicokinetics Mohd Amir Bin Arshad Toxicokinetics study on how a substance gets into the body and what happens to it in the body" The kinetics (movement) of substances
More information7-2 : Plasma Membrane and Cell Structures
7-2 : Plasma Membrane and Cell Structures Plasma Membrane of aveolar sac But first... Let s Review What is cell theory? Light microscopes vs. electron microscopes Prokaryotic vs. eukaryotic Basic Cell
More informationStudy Guide for Biology Chapter 5
Class: Date: Study Guide for Biology Chapter 5 Multiple Choice Identify the choice that best completes the statement or answers the question. 1. Which of the following led to the discovery of cells? a.
More information1. Structure A is the a. Cell wall b. Cell membrane c. Vacuole d. Lysosome
Figure 1 Use Figure 1 to answer the following questions: 1. Structure A is the a. Cell wall b. Cell membrane c. Vacuole d. Lysosome 2. Structure E controls cellular functions. It is the a. Nucleolus b.
More informationIn the space provided, write the letter of the term or phrase that best completes each statement or best answers each question.
CHAPTER 3 TEST Cell Structure Circle T if the statement is true or F if it is false. T F 1. Small cells can transport materials and information more quickly than larger cells can. T F 2. Newly made proteins
More informationCells & Cell Organelles
Cells & Cell Organelles Doing Life s Work 2009 2010 1 Types of cells bacteria cells Prokaryote no organelles animal cells Eukaryotes organelles plant cells 2 Cell size comparison Animal cell Bacterial
More informationToxicant Disposition and Metabolism. Jan Chambers Center for Environmental Health Sciences College of Veterinary Medicine
Toxicant Disposition and Metabolism Jan Chambers Center for Environmental Health Sciences College of Veterinary Medicine chambers@cvm.msstate.edu Definitions Disposition Absorption passage across membrane.
More informationCell Structure & Function. Source:
Cell Structure & Function Source: http://koning.ecsu.ctstateu.edu/cell/cell.html Definition of Cell A cell is the smallest unit that is capable of performing life functions. http://web.jjay.cuny.edu/~acarpi/nsc/images/cell.gif
More informationUnit 2:The Cell. Section 3: Organelle Structure and Function Mrs. McNamara Biology
Unit 2:The Cell Section 3: Organelle Structure and Function Mrs. McNamara Biology Organelle-cell part that performs a specific function for the cell Most are surrounded by a membrane Each helps to maintain
More informationChapters 2 and 3. Pages and Pages Prayer Attendance Homework
Chapters 2 and 3 Pages 44-45 and Pages 59-62 Prayer Attendance Homework The Cell The cell is the basic unit of life on Earth, separated from its environment by a membrane and sometimes an outer wall. Prokaryotic
More informationCell Cell
Go to cellsalive.com. Select Interactive Cell Models: Plant and Animal. Fill in the information on Plant and Animal Organelles, then Click on Start the Animation Select Plant or Animal Cell below the box.
More informationPrinciples of Toxicology: The Study of Poisons
Principles of Toxicology: The Study of Poisons Elizabeth Casarez Department of Pharmacology and Toxicology University it of Arizona The study of the adverse effects of a toxicant on living organisms Adverse
More informationWhat are the parts of a eukaryotic cell? What is the function of each part of a eukaryotic cell?
CHAPTER 3 SECTION 2 Cells: The Basic Units of Life Eukaryotic Cells BEFORE YOU READ After you read this section, you should be able to answer these questions: What are the parts of a eukaryotic cell? What
More informationBiology 137 Introduction to Toxicology Name Midterm Exam 1 Fall Semester 2001
Biology 137 Introduction to Toxicology Name Midterm Exam 1 Fall Semester 2001 Part I. Multiple choice. Two points each. 1. Toxicology is the study of A. prevalence of disease and death in a population
More informationEukaryotic Cell Structures
Comparing the Cell to a Factory Eukaryotic Cell Structures Structures within a eukaryotic cell that perform important cellular functions are known as organelles. Cell biologists divide the eukaryotic cell
More informationName Class Date. What are the parts of a eukaryotic cell? What is the function of each part of a eukaryotic cell?
CHAPTER 2 SECTION 2 Cells: The Basic Units of Life Eukaryotic Cells BEFORE YOU READ After you read this section, you should be able to answer these questions: What are the parts of a eukaryotic cell? What
More informationBIOLOGY 111. CHAPTER 3: The Cell: The Fundamental Unit of Life
BIOLOGY 111 CHAPTER 3: The Cell: The Fundamental Unit of Life The Cell: The Fundamental Unit of Life Learning Outcomes 3.1 Explain the similarities and differences between prokaryotic and eukaryotic cells
More informationCell Structure and Function Cell Structure and function
Cell Structure and Cell Structure and function Dr Badri Paudel www.badripaudel.com Smallest living unit Most are microscopic Cells Discovery of Cells Robert Hooke (mid-1600s) Observed sliver of cork Saw
More informationStandard 2 Exam Biology. 2. This macromolecule is responsible for short term energy storage and structural support in plants
1. This macromolecule is responsible for structural support, movement, enzymatic activity, cell communication, and is made of amino acids. a. Lipids b. Carbohydrates c. Proteins d. Nucleic Acids e. ATP
More informationSBI3U7 Cell Structure & Organelles. 2.2 Prokaryotic Cells 2.3 Eukaryotic Cells
SBI3U7 Cell Structure & Organelles 2.2 Prokaryotic Cells 2.3 Eukaryotic Cells No nucleus Prokaryotic Cells No membrane bound organelles Has a nucleus Eukaryotic Cells Membrane bound organelles Unicellular
More informationCells & Cell Organelles. Doing Life s Work
Cells & Cell Organelles Doing Life s Work AP Biology 2009-2010 Types of cells bacteria cells Prokaryote - no organelles Eukaryotes - organelles animal cells plant cells Cell size comparison Animal cell
More informationName: Date: Block: Biology 12
Name: Date: Block: Biology 12 Provincial Exam Review: Cell Processes and Applications January 2003 Use the following diagram to answer questions 1 and 2. 1. Which labelled organelle produces most of the
More informationTHE CELL Cells: Part 1
THE CELL Cells: Part 1 OBJECTIVES By the end of the lesson you should be able to: State the 2 types of cells Relate the structure to function for all the organelles TYPES OF CELLS There are two types of
More information(A) Cell membrane (B) Ribosome (C) DNA (D) Nucleus (E) Plasmids. A. Incorrect! Both prokaryotic and eukaryotic cells have cell membranes.
High School Biology - Problem Drill 03: The Cell No. 1 of 10 1. Which of the following is NOT found in prokaryotic cells? #01 (A) Cell membrane (B) Ribosome (C) DNA (D) Nucleus (E) Plasmids Both prokaryotic
More informationBiology 12 Cell Structure and Function. Typical Animal Cell
Biology 12 Cell Structure and Function Typical Animal Cell Vacuoles: storage of materials and water Golgi body: a series of stacked disk shaped sacs. Repackaging centre stores, modifies, and packages proteins
More informationOrganelles Found in a Generalized Animal Cell
Organelles Found in a Generalized Animal Cell 1. Cell Membrane 2. Cytoplasm 3. Nucleus 4. Nuclear Membrane 5. Nucleoplasm 6. Nucleolus 7. Chromosomes 8. Vacuole 9. Ribosomes 10. Rough Endoplasmic Reticulum
More informationParts (organelles) of the Cell
Lesson 07 Cell Organelles.notebook Parts (organelles) of the Cell Parts that provide structure and support Cell Membrane 1) Is a barrier for the cell. It controls what goes in and out of the cell. 2) It
More informationC) amount of carbon dioxide absorbed by the animal B) rate of respiration of the animal
Name: 1) A model of a section of a cell membrane is represented below. 4034-1 - Page 1 Which type of molecule is indicated by the arrow? A) carbohydrate B) protein C) lipid D) nucleotide 2) The movement
More informationFirst discovered in 1665 since then every organism observed with microscopes shows cells
The Cell Cell theory (1838): 1. All organisms are composed of one or more cells, and the life processes of metabolism and heredity occur within these cells. 2. Cells are the smallest living things, the
More informationSACE Stage 2 Biology Notes - Cells
SACE Biology Year 2016 Mark 20.00 Pages 26 Published Jan 4, 2017 SACE Stage 2 Biology Notes - Cells By Elizabeth (99.75 ATAR) Powered by TCPDF (www.tcpdf.org) Your notes author, Elizabeth. Elizabeth achieved
More informationChemical and Biochemical Mechanism Of Cell Injury.
Chemical and Biochemical Mechanism Of Cell Injury. Professor Dr. M. Tariq Javed Dept. of Pathology Faculty of Vet. Science The University Of Agriculture Faisalabad Cell Injury When the cell is exposed
More information1.3 - Cells. Chapter 3 - Cells
1.3 - Cells Chapter 3 - Cells Cells Cytology = the study of cells All animal cells have 3 main parts: Nucleus Cell Membrane Cell membrane is semipermeable Cytoplasm (cytosol): where remaining organelles
More informationCells and Cell Transport
Cells and Cell Transport Use the list below to answer question 1. Functions of a Cell Structure 1. The functions of which cell structure are described in this list? A. a lysosome B. a mitochondrion C.
More informationCells & Cell Transport. Cells
Cells & Cell Transport Cells Cell Membrane Cell membrane (plasma membrane): a phospholipid bilayer surrounding the cell Each phospholipid has a polar phosphate head and lipid tails Selectively permeable:
More informationPlant Cells. Chapter 3
Plant Cells Chapter 3 Major Learning Objectives Contrast prokaryotic and eukaryotic cells Describe the functions of 10 parts of a plant cell Summarize the similarities and differences between plant cells
More informationCell Structure and Function
Cell Structure and Function Agre and cells in the news Cells Smallest living unit Most are microscopic Discovery of Cells Robert Hooke (mid-1600s) Observed sliver of cork Saw row of empty boxes Coined
More information3- Cell Structure and Function How do things move in and out of cells? A Quick Review Taft College Human Physiology
3- Cell Structure and Function How do things move in and out of cells? A Quick Review Taft College Human Physiology How do things move in and out of cells? Things may move through cell membranes by Passive
More informationCELL PARTS TYPICAL ANIMAL CELL
AP BIOLOGY CText Reference, Campbell v.8, Chapter 6 ACTIVITY1.12 NAME DATE HOUR CELL PARTS TYPICAL ANIMAL CELL ENDOMEMBRANE SYSTEM TYPICAL PLANT CELL QUESTIONS: 1. Write the name of the cell part in the
More informationCell Structure and Organelles SBI4U 2016/10/14
Cell Structure and Organelles SBI4U 2016/10/14 Inside the cell These are generalizations, not rules! Everything inside the cell membrane besides the nucleus is called the cytoplasm; The liquid is known
More informationMid Term Review. 1. step 1, only 3. both step 1 and step 2 2. step 2, only 4. neither step 1 nor step 2
Name Mid Term Review 1. Diagrams, tables, and graphs are used by scientists mainly to 1. design a research plan for an experiment 3. organize data 2. test a hypothesis 4. predict the independent variable
More informationCell structure and function flash cards
Process Cell structure and function flash cards involved in aerobic respiration releasing ATP / energy has a double membrane folded into cristae (to make large SA) mostly occurs in mitochondria; needing
More informationCell Structure & Interactions
Cells Structures & Interactions Overview 1830s-Botanist Matthias Schleiden and zoologist Theodor Schwann were studying tissues and proposed the unified cell theory All living things are composed of one
More informationCell Category? Prokaryote
CELLS Cell Category? Prokaryote Prokaryote Eukaryote Cell Category? Cell Type? Cell Category? Cell Type? Endosymbiosis eukaryotic cells were formed from simpler prokaryotes Endo within Symbiosis together
More informationEarly scientists who observed cells made detailed sketches of what they saw.
Early scientists who observed cells made detailed sketches of what they saw. Early scientists who observed cells made detailed sketches of what they saw. CORK Early scientists who observed cells made detailed
More informationCELLS. Cells. Basic unit of life (except virus)
Basic unit of life (except virus) CELLS Prokaryotic, w/o nucleus, bacteria Eukaryotic, w/ nucleus Various cell types specialized for particular function. Differentiation. Over 200 human cell types 56%
More informationNucleic acids. Nucleic acids are information-rich polymers of nucleotides
Nucleic acids Nucleic acids are information-rich polymers of nucleotides DNA and RNA Serve as the blueprints for proteins and thus control the life of a cell RNA and DNA are made up of very similar nucleotides.
More informationCELLS CELL THEORY. There are two types of cells: 9/26/2016 CELLULAR COMPONENTS & PROCESES. Which is more complicated? REMEMBER YOU ARE EUKARYOTIC!
CELLS CELLULAR COMPONENTS & PROCESES CELL THEORY 1. All living things are made up of one or more cells 2. The cell is the smallest unit of life. 3. All new cells come from pre-existing cells. There are
More informationJourney to the World of Cells
Journey to the World of Cells Starting Point for Life All living organisms on Earth are divided into pieces called cells. Formed from Proteins Organelles Make larger pieces called Tissues and systems Main
More informationChoosing What You Eat and Why. Chapter 1 BIOL1400 Dr. Mohamad H. Termos
Choosing What You Eat and Why Chapter 1 BIOL1400 Dr. Mohamad H. Termos Objectives Following this lecture, you should be able to describe: - Nutrition definition - Sources of nutrients - Energy sources
More informationThe Cell and Cellular transport
Cell theory (1838): The Cell 1. All organisms are composed of one or more cells, and the life processes of metabolism and heredity occur within these cells. 2. Cells are the smallest living things, the
More informationFundamentals of Pharmacology for Veterinary Technicians Chapter 4
(A) (B) Figure 4-1 A, B (C) FIGURE 4-1C The active transport process moves particles against the concentration gradient from a region of low concentration to a region of high concentration. Active transport
More informationCell are made up of organelles. An ORGANELLE is a specialized subunit within a cell that has a specific function.
Plant and Animal Cells The Cell Theory All living things are made up of one or more cells. All cells come from other cells. Organization of Living Things Cell are made up of organelles. An ORGANELLE is
More informationRenata Schipp Medical Biology Department
Renata Schipp Medical Biology Department Deffinition of cell The cell is the smallest structural and functional unit of all known living organisms The cell was discovered by Robert Hooke in 1665 and also
More informationBasic Structure of a Cell
Basic Structure of a Cell 1 Introduction to Cells Cells are the basic units of organisms Cells can only be observed under microscope Basic types of cells: Animal Cell Plant Cell Bacterial Cell 2 Number
More informationA small, membrane-bound compartment capable of performing all the basic functions of life
AP Biology The Cell The Cell Cell: A small, membrane-bound compartment capable of performing all the basic functions of life Discovery of Cells: - 17 th century - A Dutch clothing dealer named Antonie
More informationChapter 3. Cell Structure
Chapter 3 Cell Structure Looking at Cells l The invention of microscopes allowed scientists to view cells for the first time l Scientists use the metric system to measure the size of cells l Metric Units
More informationChapter 7: Cells Review Packet Name: 1. endoplasmic reticulum The organelle made up of internal membranes where lipids and proteins are synthesized
Chapter 7: Cells Review Packet Name: Organelles 1. endoplasmic reticulum The organelle made up of internal membranes where lipids and proteins are synthesized 2. Golgi apparatus Enzymes in this apparatus
More informationTest Review Worksheet 1 Name: Per:
Test Review Worksheet 1 Name: Per: 1. Put the following in order according to blood flow through the body, starting with the lungs: Lungs, right atrium, left atrium, right ventricle, left ventricle, aorta,
More informationFirst to View Cells. copyright cmassengale
CELL THEORY All living things are made of cells Cells are the basic unit of structure and function in an organism (basic unit of life) Cells come from the reproduction of existing cells (cell division)
More information4. Lysosomes, Smooth Endoplasmic Reticulum, Mitochondria, and Inclusions
4. Lysosomes, Smooth Endoplasmic Reticulum, Mitochondria, and Inclusions Undergraduate Graduate Histology Lecture Series Larry Johnson, Professor Veterinary Integrative Biosciences Texas A&M University
More informationThe Study of Cells The diversity of the cells of the body The following figure shows the proportion of cell size of the variety of cells in the body
Adapted from Martini Human Anatomy 7th ed. Chapter 2 Foundations: The Cell Introduction There are trillions of cells in the body Cells are the structural building blocks of all plants and animals Cells
More informationToxicology. Toxicity. Human Health Concerns. Health Effects of Hazardous Materials
Human Health Concerns Health Effects of Hazardous Materials Toxicology Study of the nature, effects, and detection of poisons in organisms Humans are obvious focal point Other species and ecosystem function
More informationCytoskeleton. Provide shape and support for the cell. Other functions of the cytoskeleton. Nucleolus. Nucleus
Chapter 4: Cell Structure and Function Cytoskeleton The cytoskeleton is a network of fibers that organizes structures and activities in the cell. Microtubules (the largest) Intermediate fibers Microfilaments
More informationAP Biology
Tour of the Cell (1) 2007-2008 Types of cells Prokaryote bacteria cells - no organelles - organelles Eukaryote animal cells Eukaryote plant cells Cell Size Why organelles? Specialized structures - specialized
More informationNutrition and Energy 1
Nutrition and Energy 1 Food Energy The ingestion of food serves two primary functions: 1. it provides a source of energy 2. it provides raw materials the animal is unable to manufacture for itself. 2 Basal
More informationCHAPTER 4 - CELLS. All living things are made up of one or more cells. A cell is the smallest unit that can carry on all of the processes of life.
CHAPTER 4 - CELLS Objectives Name the scientists who first observed living and nonliving cells. Summarize the research that led to the development of the cell theory. State the three principles of the
More informationCells and Tissues 3PART A. PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College
PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Cells and Tissues 3PART A Cells and Tissues Carry out all chemical activities needed to sustain life
More informationNutrients. Chapter 25 Nutrition, Metabolism, Temperature Regulation
Chapter 25 Nutrition, Metabolism, Temperature Regulation 25-1 Nutrients Chemicals used by body to produce energy, provide building blocks or function in other chemical reactions Classes Carbohydrates,
More informationCELL STRUCTURE AND CELL ORGANISATION
CELL STRUCTURE AND CELL ORGANISATION CHAPTER 2 https://wickedbiology.wordpress.com Cellular components of animal & plant cells https://wickedbiology.wordpress.com Plant Cells Cell wall Plasma membrane
More informationPlasma Membrane. comprised of a phospholipid bilayer and embedded proteins separates the cells s contents from its surroundings
Cell Organelles Plasma Membrane comprised of a phospholipid bilayer and embedded proteins separates the cells s contents from its surroundings Cytosol the fluid Cytoplasm cell interior, everything outside
More information4/12/17. Cells. Cell Structure. Ch. 2 Cell Structure and Func.on. Range of Cell Sizes BIOL 100
Ch. 2 Cell Structure and Func.on BIOL 100 Cells Fundamental units of life Cell theory All living things are composed of one or more cells. The cell is the most basic unit of life. All cells come from pre-existing
More informationCHEMISTRY OF LIFE 30 JANUARY 2013
CHEMISTRY OF LIFE 30 JANUARY 2013 Lesson Description In this lesson, we will: Investigate the structure and function of molecules that are essential for life. Key Concepts Terminology A molecule is any
More informationLooking Inside Cells
Looking Inside Cells Inner Life of a Cell http://www.bing.com/videos/search?q=inside +cell+animation&form=hdrsc3#view=detail &mid=4ba834420ea307a061374ba834420ea 307A06137 Cell Defined Cells-Basic unit
More informationEVE 491/591 Toxicology. Toxicant Distribution 2/20/2014
EVE 491/591 Toxicology Lecture #8 1. Distribution, Storage, Elimination, and Biotransformation of Toxicants 2. Case study #2 Part II Toxicant Distribution Distribution: the process in which a chemical
More informationBiochemical Concepts. Section 4.6 The Chemistry of Water. Pre-View 4.6. A Covalent Polar Molecule
Biochemical Concepts Section 4.6 The Chemistry of Water Pre-View 4.6 Polar molecule a molecule that has a partial positive charge on one end and a partial negative charge on the other end Hydrogen bond
More informationTypes of cells. Cell size comparison. The Jobs of Cells 10/5/2015. Cells & Cell Organelles. Doing Life s Work
Types of cells Prokaryote Cells & Cell Organelles bacteria cells Doing Life s Work Eukaryotes 2009-2010 animal cells plant cells Cell size comparison Animal cell Bacterial cell most bacteria (prokaryotic)
More informationCh. 6: A Tour of the Cell
Ch. 6: A Tour of the Cell 1. Compare the 2 Types of Cells PROKARYOTES BOTH EUKARYOTES Domain: Domain: Relative Size & Complexity: Relative Size & Complexity: No DNA in No Examples: Has Has Examples: 2.
More informationarea of toxicology: The following are examples of some LD50 Values LD50 Dose Response Curve Sample
Chemical hazards are associated with a significant number of high profile food safety alerts, recalls and withdrawals. The principles of HACCP require chemical hazards to be considered during the hazard
More informationCell Structure and Function
Cell Structure and Function Agre and cells in the news Cells Smallest living unit Most are microscopic Discovery of Cells Robert Hooke (mid-1600s) Observed sliver of cork Saw row of empty boxes Coined
More informationCytosol the fluid Cytoplasm cell interior, everything outside the nucleus but within the cell membrane, includes the organelles, cytosol, and
Cell Organelles Plasma Membrane comprised of a phospholipid bilayer and embedded proteins Outer surface has oligosaccharides separates the cells s contents from its surroundings Cytosol the fluid Cytoplasm
More informationThe Cell. Biology 105 Lecture 4 Reading: Chapter 3 (pages 47 62)
The Cell Biology 105 Lecture 4 Reading: Chapter 3 (pages 47 62) Outline I. Prokaryotic vs. Eukaryotic II. Eukaryotic A. Plasma membrane transport across B. Main features of animal cells and their functions
More informationA. Major parts 1. Nucleus 2. Cytoplasm a. Contain organelles (see below) 3. Plasma membrane (To be discussed in Cellular Transport Lecture)
Lecture 5: Cellular Biology I. Cell Theory Concepts: 1. Cells are the functional and structural units of living organisms 2. The activity of an organism is dependent on both the individual and collective
More informationObjectives. By the end of the lesson you should be able to: State the 2 types of cells Relate the structure to function for all the organelles
Biology 11 THE Cell Objectives By the end of the lesson you should be able to: State the 2 types of cells Relate the structure to function for all the organelles Types of Cells There are two types of cells:
More informationTEST NAME:Cells and Health TEST ID: GRADE:08 - Eighth Grade SUBJECT:Life and Physical Sciences TEST CATEGORY: School Assessment
TEST NAME:Cells and Health TEST ID:1326431 GRADE:08 - Eighth Grade SUBJECT:Life and Physical Sciences TEST CATEGORY: School Assessment Cells and Health Page 1 of 15 Student: Class: Date: 1. Which best
More informationLIVING SYSTEMS APPEAR COMPLEX BUT THERE IS AN UNDERLYING SIMPLICITY AND ELEGANCE:
CHM333 LECTURE 1: 8/26/09 FALL 2009 Professor Christine Hrycyna What is Biochemistry? Simplest definition: Chemistry of the living cell Uses basic laws of chemistry, biology and physics to explain processes
More informationName: Class: Date: Cell Structure and Transport Take Home Exam
Name: Class: Date: Cell Structure and Transport Take Home Exam 1. Which is found in the nucleus? (1.) ribosome (2.) centrosome (3.) vacuole (4.) lysosome (5.) chromosome 2. Which structure composed mainly
More informationEffects of Agriculture on Global Population
Effects of Agriculture on Global Population Remove unwanted plants and animals from a farm area. Plants and animals evolved into a symbiotic relationship. Social organization. Structure. Affluence. Population
More information(impermeable; freely permeable; selectively permeable)
BIOL 2457 CHAPTER 3 Part 1 SI 1 1. A is the basic structure of life. 2. The gelatinous inside of the cell is called the. 3. Name the structure that increases the cell s surface area? 4. Name the structure
More informationCell Anatomy Anatomy = the study of the structures and components of an organism
Cell Anatomy Anatomy = the study of the structures and components of an organism -Types of Cells: 1) Prokaryotic = simple, primitive = no membrane bound nucleus, only a dense, nuclear area = single-celled
More informationCELL (PLASMA) MEMBRANE
CELL (PLASMA) MEMBRANE Separates cell from its environment Controls substances that enter and leave the cell Selectively permeable allows certain substances to pass COMPOSITION Composed of 2 layers of
More informationCh 3 Cell Structure 10/1/2008. Cells Under the Microscope. Natural laws limit cell size. Biology Periods 2, 3, 4, & 6 Mrs.
Ch 3 Cell Structure Cells Under the Microscope Electron microscopes have much higher magnifying and resolving powers than light microscopes. Biology Periods 2, 3, 4, & 6 Mrs. Stolipher Cell size and shape
More information