Dialogue on the stability of probiotics
|
|
- Barbra Rogers
- 6 years ago
- Views:
Transcription
1 Dialogue on the stability of probiotics Learning from the US Dietary Supplements market Fernando Ferrer, MBA Auditorium ANVISA Basilia, Brazil. June 19, 2017
2 Disclaimer The views and opinions expressed in this session are those of the individual presenters and should not be attributed to their employers nor the organizers of this event. Fernando Ferrer, MBA Multinational Partnerships LLC 2
3 Objective Discuss the world scenario on the regulation of probiotics and the divergences for the framing of these products in the categories of medicines and foods. The intend is also to discuss requirements for the development, use of claims and production of probiotics. Discutir o cenário mundial sobre a regulação de probióticos e as divergências para o enquadramento destes produtos nas categorias de medicamentos e alimentos. Pretende-se também debater os requisitos para o desenvolvimento, uso de alegações e produção dos probióticos. Fernando Ferrer, MBA Multinational Partnerships LLC 3
4 Abstract Natural products challenge us to create and accept different standards. Science and usage show us the benefits and safety of using probiotics. Food and dietary supplements do not have the same technical requirements of stability for medicines; however, this stability is taken into consideration from the moment of developing every industrial production formula. The variety of probiotics and their multiple applications in industrialized products makes it difficult to develop and implement regulations covering each and every one of its technicalities. This presentation shows the stability information of some probiotic products marketed in the US as dietary supplements. The proposed way to rapidly advance with a regulatory and industrial agreement is to break paradigms for a better inclusion of natural products, to seek simpler and broader regulations, and to understand and accept the technical reasons considered by industry to neutralize the aspects that may affect the stability of probiotics in food and medicines. Fernando Ferrer, MBA Multinational Partnerships LLC 4
5 Content Dialogue on the stability of probiotics 1 introduction 2 Learning from the US Dietary Supplements market 3 discussion Conclusion Fernando Ferrer, MBA Multinational Partnerships LLC 55
6 Natural products 1 introduction Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. They include very small molecules, such as urea, and complex structures, such as Taxol. As they may only be isolable in small quantities, have interesting biological activity and chemical structures, natural product synthesis poses an interesting challenge in organic chemistry. Source: Nature, founded in Fernando Ferrer, MBA Multinational Partnerships LLC 6
7 Definition of probiotics Live microorganisms which when administered in adequate amounts confer a health benefit on the host Joint FAO/WHO Working Group Report on Drafting Guidelines for the Evaluation of Probiotics in Food London, Ontario, Canada, April 30 and May 1, 2002 Source: WHO Fernando Ferrer, MBA Multinational Partnerships LLC 7
8 Bacteria are among the first forms of life that appeared on Earth can be found virtually everywhere at temperature below 0 C or above 120 C low (0.007 atm) or high pressure (380 atm) with or without O 2 in radioactive waste are vital for humans Fernando Ferrer, MBA Multinational Partnerships LLC 8
9 most bacteria reside only in the colon (which has a volume of 0.4 litres) The bacterial content of the colon exceeds all other organs ly/2016/01/06/ full.pdf Fernando Ferrer, MBA Multinational Partnerships LLC 9
10 Most common microorganisms used as probiotics Lactobacillus Bifidobacterium genera Other bacterial genera, including Enterococcus, Streptococcus, and Escherichia Fungus Saccharomyces boulardii Fernando Ferrer, MBA Multinational Partnerships LLC 10
11 FDA Generally Recognized as Safe (GRAS) GRN No. Substance Date of closure 660 Bacillus coagulans GBI-30, Jan Bacillus coagulans SBC37-01 spore preparation 28-Apr Bacillus coagulans SNZ1969 spores preparation 29-Feb Bacillus coagulans strain Unique IS2 spores preparation 23-Mar Bifidobacterium animalis subsp. lactis strain Bf-6 29-Sep Bifidobacterium animalis subsp. lactis strains HN019, Bi-07, Bl-04 and B Apr Bifidobacterium breve M-16V 30-Sep Bifidobacterium breve M-16V 27-Sep Bifidobacterium breve M-16V 27-Sep-13 Bifidobacterium lactis strain Bb12 and Streptococcus thermophilus strain 49 Th4 19-Mar Bifidobacterium longum strain BB536 8-Jul Inactivated Bacillus coagulans GBI-30, Mar-17 Source: webpage FDA, list of some probiotics listed by May 17, 2017 Fernando Ferrer, MBA Multinational Partnerships LLC 11
12 FDA Generally Recognized as Safe (GRAS) (2) GRN No. Substance Date of closure 502 Lactobacillus acidophilus La Aug Lactobacillus acidophilus NCFM 19-Apr Lactobacillus acidophilus, Lactobacillus lactis, and Pediococcus acidilactici 7-Dec Lactobacillus casei strain Shirota 10-Dec Lactobacillus casei subsp. rhamnosus strain GG 29-May Lactobacillus fermentum CECT Mar Lactobacillus reuteri strain DSM Mar Lactobacillus reuteri strain DSM Nov Lactobacillus reuteri strain DSM Mar Lactobacillus reuteri strain NCIMB Feb Lactobacillus rhamnosus strain HN001 1-Nov Lactobacillus rhamnosus strain HN001 produced in a milk-based medium 31-Aug-09 Source: webpage FDA, list of some probiotics listed by May 17, 2017 Fernando Ferrer, MBA Multinational Partnerships LLC 12
13 Loses in any food or medical industrialized product Formulas must include overdoses to cover inherent loses in Manufacturing Analytical method(s) Storage(s) and logistics One size doesn't fit all. Variations due to diverse factors, e.g. components, product, forms, technologies, environment, etc. Fernando Ferrer, MBA Multinational Partnerships LLC 13
14 Summarizing Natural Products - Microorganisms Consumer Regulations Industrialized products Fernando Ferrer, MBA Multinational Partnerships LLC 14
15 2 Learning from the US Dietary Supplements market Stability of formulations of probiotics in the US market FOOD SUPPLEMENTS
16 Probiotics as Food Supplements Exhibition at Drugstores Fernando Ferrer, MBA Multinational Partnerships LLC 16
17
18
19 Examples of current products in the US market DECLARING JUST THE CONTENT
20 Rite Aid 250mg Saccharomyces boulardii serving 1 capsule Content or potency is not related to manufacture or expiration dates Store at room temperature. For best results, we recommend you store this product in the original package. Fernando Ferrer, MBA Multinational Partnerships LLC 20
21 RB 2 billion viable cells serving 1 capsule Potency is not related to manufacture or expiration dates : guaranteed for labeled potency, but has a % of survivability claim Fernando Ferrer, MBA Multinational Partnerships LLC 21
22 Examples of current products in the US market DECLARING POTENT AT TIME OF MANUFACTURE
23 Church & Dwight - PB8 14 billion Serving size 2 caps Bacteria count will vary after time of manufacture. Store in a cool, dry place; best if refrigerated after opening Fernando Ferrer, MBA Multinational Partnerships LLC 23
24 N s B - 20 billion live cultures serving 1 capsule 20 billion active cultures per serving guaranteed at the time of manufacture. Refrigerate after opening Fernando Ferrer, MBA Multinational Partnerships LLC 24
25 Examples of current products in the US market DECLARING POTENT PRIOR TO EXPIRATION
26 i-health 10 billion CFUs serving 1 capsule Guaranteed potency thorough date on box when stored according to instructions. Store Culturelle in a cool, dry place away from direct sunlight. Keep Culturelle at room temperature or below. Fernando Ferrer, MBA Multinational Partnerships LLC 26
27 Bayer 2 billion cells serving 1 capsule Prior to expiration Store at a room temperature. Avoid excessive heat. Replace cap after use. Fernando Ferrer, MBA Multinational Partnerships LLC 27
28 Examples of current products in the US market DECLARING POTENT AT THE TIME OF MANUFACTURE AND PRIOR TO EXPIRATION
29 Rite Aid 5 billion CFUs serving 1 capsule Product contains 5 billion live cells when manufactured and a minimum of 1 billion live cells at time of expiration Store at 25 C (77 F). Avoid excessive heat and humidity. Protect from humidity. Fernando Ferrer, MBA Multinational Partnerships LLC 29
30 P&G 4mg 1 billion CFU serving 1 capsule Contains 1 x 10 9 (one billion) live bacteria/cfu when manufactured, and provides an effective level of bacteria (1x10 7 CFU)* until at least the best by date *10 million Store at room temperature. For best results we recommend you store Align in the original blister package. Fernando Ferrer, MBA Multinational Partnerships LLC 30
31 Loses might be up to 99% and 80% in 2 years Align 1000 million to 10 million Rite Aid 5 billion to 1 billion Fernando Ferrer, MBA Multinational Partnerships LLC 31
32 Loses in any food or medical industrialized product Formulas must include overdoses to cover inherent loses in Manufacturing 5? % Analytical method(s) 5-25% Storage(s) and logistics? % One size doesn't fit all. Variations due to diverse factors, e.g. components, product, forms, technologies, environment, etc. Fernando Ferrer, MBA Multinational Partnerships LLC 32
33 3 discussion Discussion Is it feasible for natural products to respond always to the rational of synthetic products created by man? Is it impossible to create and implement an efficient regulatory system that can fully encompass the wide range of probiotics? Is the industry cheating the consumers and the authorities when adding an overdose? Fernando Ferrer, MBA Multinational Partnerships LLC 33
34 No
35 Simplicity Complicating simplicity is simple but simplifying the complex is very difficult Simplicity is the ultimate sophistication. Leonardo da Vinci Don t make the process harder than it is. Jack Welch Life is really simple, but we insist on making it complicated. Confucius Simplicity is the most difficult thing to secure in this world; it is the last limit of experience and the last effort of genius. George Sand Fernando Ferrer, MBA Multinational Partnerships LLC 35
36 Conclusion Break paradigms. Natural products require a different vision than synthetic products created by man. Simplify. The wide variety of probiotics and their applications in the areas of food and medicine can be regulated based on a simple and broad regulation. Compliance. Industrialized products require overdosages that are specific to each process and product, levels can not be generalized; the industry is not intending to mislead the system and the addition of an overdose is sustained by valid reasons. Fernando Ferrer, MBA Multinational Partnerships LLC 36
37 Muito Obrigado Thank you Fernando Ferrer, BSc. MBA Phone fferrer@multinationalpartnerships.com Multinational Partnerships is a Registered Trade Mark of Multinational Partnerships LLC
38 Members of Fernando Ferrer, MBA Multinational Partnerships LLC 38
39 Members of Fernando Ferrer, MBA Multinational Partnerships LLC 39
HMP is lead by NIH but is an International Consortium.
Human Microbiome The Human Microbiome Project was one of the spin offs of the Human Genome Project. The HMP project started in 2007 with the overall goal of Characterizing the Human Microbiome and determine
More informationUnderstanding Today s Probiotics Regulations in South East Asia. Wai Mun Poon Regulatory Affairs Consultant
Understanding Today s Probiotics Regulations in South East Asia Wai Mun Poon Regulatory Affairs Consultant waimun@wongsjasia.com Probiotic Foods in South East Asia More probiotic foods are being introduced
More informationהשפעת חיידקים פרוביוטיים
השפעת חיידקים פרוביוטיים החיים בחלל )המעי(... על רון שאול יחידת גסטרו ילדים מרכז רפואי רמב"ם Introduction The intestinal microflora primarily in the large bowel consists mostly on benign bacterial species
More informationProbiotics. NOW Guide to Probiotics
Probiotics NOW Guide to Probiotics The Health Benefits of Probiotics Microorganisms for Health Did you know that you have trillions of microorganisms, including bacteria and yeast, living in and on your
More informationThe Gut Microbiome: 101 Justin Carlson University of Minnesota
The Gut Microbiome: 101 Justin Carlson University of Minnesota Where are we now? 360 B.C. 2003 Human Gut Microbes Associated With Obesity Ley et al., Nature. 2006. Consumer Driven Science For Better of
More informationVitalBiome HEALTHY GUT. HAPPY MIND. HEALTHY YOU.*
VitalBiome TM HEALTHY GUT. HAPPY MIND. HEALTHY YOU.* Could your gut microbiome be at risk? (The answer might surprise you.) Your microbiome the good and bad microbes living in and on your body has a big
More informationProbiotics and Prebiotics: Frequently Asked Questions
1. What are probiotics? Our intestines contain over 100 trillion bacteria. This is 1,000 times the number of cells that make up the entire human body. Many of these bacteria play an important role in protecting
More informationUSP Probiotics Program
USP Dietary Supplements Stakeholder Forum Tuesday, May 15, 2018 USP Probiotics Program Mike Bradley, Ph.D. Member USP Probiotic Expert Panel Member USP Non-Botanical Dietary Supplement Expert Committee
More informationProbiotic Series. Product Innovation for a Healthy Microbiome* Featuring New Products including the PureBi Ome Line
Probiotic Series Product Innovation for a Healthy Microbiome* Featuring New Products including the PureBi Ome Line *These statements have not been evaluated by the Food and Drug Administration. These products
More informationTHE PROBIOTIC PRODUCT RANGE HAS SET A NEW INDUSTRY STANDARD BY OFFERING THREE PRODUCTS WITH A PROVEN POTENCY MULTI STRAIN BACTERIA AT THE TIME OF
THE PROBIOTIC PRODUCT RANGE HAS SET A NEW INDUSTRY STANDARD BY OFFERING THREE PRODUCTS WITH A PROVEN POTENCY MULTI STRAIN BACTERIA AT THE TIME OF CONSUMPTION WHICH ARE STABLE AT NORMAL ROOM TEMPERATURE
More informationMore than a gut feeling: How the microbiota improves health
More than a gut feeling: How the microbiota improves health Amanda Ramer-Tait, PhD Harold and Esther Edgerton Assistant Professor of Immunology and Microbiology Department of Food Science, University of
More informationProbiotics: Their Role in Medicine Today. Objectives. Probiotics: What Are They? 11/3/2017
Probiotics: Their Role in Medicine Today Viki Barr Pharm.D., BCPS AQ ID Assistant Professor, Pharmacy Practice Rosalind Franklin University of Medicine and Science Clinical Pharmacist, Infectious Diseases
More informationINDEX. THT company history Your bacteria producer Probiotics - pure culture Probiotics - formulations and finished products...
1 INDEX THT company history... 03 Your bacteria producer... 04 Probiotics - pure culture... 05 Probiotics - formulations and finished products... 06 Packaging services... 06 Tailor made... 07 Prolactys...
More informationUNDERSTANDING PROBIOTIC SUPPLEMENTS
Slide 1 UNDERSTANDING PROBIOTIC SUPPLEMENTS Slide 2 Probiotics Health Canada Definition: Probiotics are considered to be live microorganisms which, when administered in adequate amounts, confer a health
More informationWhat Are Probiotics? PROBIOTICS
PROBIOTICS What Are Probiotics? Probiotics are living, microscopic (very small) organisms that can help your gut health. Most often, probiotics are bacteria, but they may also be other organisms, such
More informationPROBIONA. PROBIOTICS with 5 bacterial strains. Suitable during and after the use of antibiotics to restore intestinal microflora.
PROBIONA Probiotic supplement for adults PROBIOTICS with 5 bacterial strains Suitable during and after the use of antibiotics to restore intestinal microflora. 2.850 billion cfu per capsule guaranteed
More informationPROBIOTICS. The Ultimate Flora Difference
In the Refrigerator Section! PROBIOTICS High-Potency Daily, Critical Care and Targeted Probiotic Formulas to Improve Regularity, Strengthen Natural Defenses and Promote Overall Digestion * The ReNew Life
More informationNEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd.
NEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd. What we already know. Functional Foods - foods that provide a health benefit beyond the traditional nutrients it contains.. American Dietetics
More informationUNDERSTANDING PROBIOTIC SUPPLEMENTS
UNDERSTANDING PROBIOTIC SUPPLEMENTS Probiotics Health Canada Definition: Probiotics are considered to be live microorganisms which, when administered in adequate amounts, confer a health benefit on the
More informationPROBIOTICS. what they are and what they can do for you. A patient s guide from your doctor and
PROBIOTICS what they are and what they can do for you A patient s guide from your doctor and Probiotics Products containing probiotics have flooded the market in recent years. As more people seek natural
More informationProbiotics : What we Know and Where we are Going Next
Probiotics : What we Know and Where we are Going Next Neerja Hajela, Ph.D. General Manager - Science and Regulatory Affairs Yakult Danone India Pvt. Ltd. Functional Food Market Probiotics an important
More informationPROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT PROBIOTICS: WHAT ARE THEY, AND HOW DO THEY WORK? Karen Jensen, (Retired ND)
PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT Karen Jensen, (Retired ND) Today many people are aware of the benefits of maintaining a healthy gut. As a result, probiotic use is becoming ever more popular.
More informationProbiotics in Pediatric Health. AANP Annual Convention
Probiotics in Pediatric Health AANP Annual Convention Don Brown, ND July 12, 2017 Human Microbiome Richness and Metabolic Markers Human gut microbial composition was studied in 292 Danish adults Individuals
More informationGuidance Document The Use of Probiotic Microorganisms in Food
Guidance Document The Use of Probiotic Microorganisms in Food Food Directorate Health Products and Food Branch Health Canada April 2009 Page 1 of 8 I. Introduction Purpose 1. The purpose of this Guidance
More informationParticipants. probiotic. /placebo)
Table S1. Demographic characteristics of trials included in the meta-analysis. Study Birth weight (mean±sd) Gestation (wk) Feeding patterns Participants (probiotic /placebo) Probiotic agents Dosage Duration
More informationPROSPERO International prospective register of systematic reviews
PROSPERO International prospective register of systematic reviews Strains on the market: an investigation of the probiotic strains in the Canadian food supply and a review of their health effects Mary
More informationHMF Probiotics PROFESSIONAL PRODUCT GUIDE
HMF Probiotics PROFESSIONAL PRODUCT GUIDE NEW Research-driven Proprietary, human-sourced strains Visit wwwseroyalcom/genestrabrands to view the entire GENESTRA BRANDS line Scientifically sound, quality
More informationProbiotics and prebiotics
World Gastroenterology Organisation Global Guidelines Probiotics and prebiotics February 2017 WGO Review Team Francisco Guarner (Chair, Spain), Mary Ellen Sanders (Co-Chair, USA), Rami Eliakim (Israel),
More informationPlexus VitalBiome Healthy gut. Happy mind.
Plexus VitalBiome Healthy gut. Happy mind. A revolutionary probiotic supplement that contains eight clinically studied probiotic strains that help improve health and mood while reducing feelings of stress
More informationProbiotics and prebiotics
World Gastroenterology Organisation Global Guidelines Probiotics and prebiotics February 2017 WGO Review Team Francisco Guarner (Chair, Spain), Mary Ellen Sanders (Co-Chair, USA), Rami Eliakim (Israel),
More informationEED INTERVENTIONS 3.0
EED INTERVENTIONS 3.0 Produced by: Kidane, L.; Osterman, A.; Babigumira, J. Agenda Agenda Project Background and Objectives Approach & Rationale Methods Results Discussion and Next Steps 2 Project Background
More informationEUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL. Opinion on the use of certain micro-organisms as additives in feedingstuffs
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Scientific Opinions C2 - Management of scientific committees II; scientific co-operation and networks Opinion on the
More informationRole of Food Matrix for Probiotic Effects
Role of Food Matrix for Probiotic Effects W. Kneifel Department of Food Science and Technology BOKU University of Natural Resources and Life Sciences Vienna Hohenheim, 15 Oct.. 2010 wolfgang.kneifel@boku.ac.at
More informationHealthy Gut, Healthy Body
September 2018 Healthy Gut, Healthy Body Science tells us that the bacteria in our bodies outnumber our cells 10 to 1. And it s supposed to be that way. Research has shown that the human microbiome, an
More informationMaterials and Methods UDC :
www.imiamn.org.ua /journal.htm 28 UDC 57.084.1:57.083.3 SURVIVAL OF MICROORGANISMS FROM MODERN PROBIOTICS IN MODEL CONDITIONS OF THE INTESTINE Kabluchko T.V., Bomko T.V., Nosalskaya T.N., Martynov A.V.,
More informationSUPER PROBIO OR... 1 capsule! 20 BILLION. 40 pots WORLDWIDE BACTERIA PER CAPSULE PRACTITIONER STRENGTH
WORLDWIDE HEALTH CENTER Natural Health Products & Remedies Important note: This product fact sheet is for professional use and contains guideline information only. A direct copy of the information contained
More information70 % OF YOUR IMMUNE SYSTEM CELLS ARE LINKED TO THE GUT.
TM HEALTHY GUT HAPPY YOU TM Trillions of bacterial cells live in your gut. Some of them are good for you. The rest of them? Not so much. GUT HEALTH MATTERS BIG TIME 90% OF YOUR BODY S MOOD-BOOSTING SEROTONIN
More informationDegradation of vitamins, probiotics and other active ingredients caused by exposure to heat, water and sunlight
https://www.nutraceuticalbusinessreview.com/technical/article_page/degradation_of_vitamins_probio tics_and_other_active_ingredients_caused_by_exposure_to_heat_water_and_sunlight/145924/cn1529 85 Degradation
More informationPerfect Biotics Reviews: We Never Expected This -- Probiotic America Reviewed
Perfect Biotics Reviews: We Never Expected This -- Probiotic America Reviewed Perfect Biotics by Probiotic America Review - Latest Report Now In. This May Change Your Mind! Crucial Update: David Kingston
More informationProduct Sales Training Guide GI-ProBalance Slimsticks Probiotic and Prebiotic Dietary Supplement
Product Sales Training Guide GI-ProBalance Slimsticks Probiotic and Prebiotic Dietary Supplement Mannatech s GI-ProBalance Slimsticks Product Sales Training Guide has been created to assist you in understanding
More informationStudy summaries L. casei 431
This binder provides you with summaries of selected publications on Lactobacillus paracasei subsp. paracasei L. casei 431. The publications are clinical studies performed in humans documenting the effects
More informationTOP 10 LEAKY GUT SUPPLEMENTS
TOP 10 LEAKY GUT SUPPLEMENTS HEALING LEAKY GUT Leaky Gut Supplements Leaky gut syndrome is a condition where undigested proteins like gluten, toxins and microbes can pass into the bloodstream. Another
More informationManipulating the gut microbiome
Manipulating the gut microbiome William DePaolo, PhD Associate Professor Medicine Director Center for Microbiome Sciences & Therapeutics University of Washington Microbiota The actual bugs that reside
More informationIncreasing barrier function with multispecies probiotics
Increasing barrier function with multispecies probiotics Elsbeth Pekelharing, MSc Science Liaison We strive for the most effective microbiome management solutions with our evidence-based & indication-specific
More informationSCIENTIFIC OPINION. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) 2. European Food Safety Authority (EFSA), Parma, Italy
SCIENTIFIC OPINION Scientific Opinion on the substantiation of health claims related to non-characterised microorganisms pursuant to Article 13(1) of Regulation (EC) No 1924/2006 1 EFSA Panel on Dietetic
More informationBio Pro 365. Product Summary. Ingredients. Prebiotic Probiotic Blend. Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend
Bio Pro 365 Prebiotic Probiotic Blend Product Summary Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend specifically designed to protect and enhance all aspects of the digestion
More informationEFFECTS OF ALETA IN PROMOTING THE GROWTH OF PROBIOTIC BACTERIA: IN VITRO STUDY
2 Senoko Drive 758 200 Singapore tel: +65.6755.633 www.kemin.com EFFECTS OF ALETA IN PROMOTING THE GROWTH OF PROBIOTIC BACTERIA: IN VITRO STUDY Lakshmibai Vasanthakumari Bindhu. Ph.D Abstract: It is well
More informationUltra Probiotics Gets New Formula
MARCH 2017 Ultra Probiotics Gets New Formula Multiple Strains, Gluten Free, Shelf Stable, Saves Money ALTRUM Ultra Probiotics has been a best-seller since its introduction in 2013. Beginning in March,
More informationProbiotic yoghurt and supplements: Retail sales in the EU Supplements and yoghurts to record 4%, and -1% growth over
Probiotic yoghurt and supplements: Retail sales in the EU Supplements and yoghurts to record 4%, and -1% growth over 217-218 1 Probiotic yoghurt and supplements in the EU, retail sales, 29-218 7 1% 6 8%
More informationLavanya Nutankalva,MD Consultant: Infectious Diseases
Lavanya Nutankalva,MD Consultant: Infectious Diseases Introduction The word Probiotic was derived from the Greek phrase meaning for life." was first coined in the 1960s by Lilly and Stillwell. Probiotics
More informationPROBIOTIC RESEARCH REVIEW
Probiotics in the Prevention of Eczema: A Randomised Controlled Trial (Allen at al. 2014) The probiotic formula that is used in GENESTRA BRANDS HMF Baby B and HMF Baby F was found to safely and effectively
More informationEED INTERVENTIONS: PRE- AND PRO-BIOTIC SAFETY
EED INTERVENTIONS: PRE- AND PRO-BIOTIC SAFETY Produced by: Dietrich, C.; Kidane, L.; Babigumira, J. Agenda Agenda Timeline Project Background and Objectives Key Takeaways Approach & Rationale Methods Results
More informationProbiotic. Product Guide
Probiotic Product Guide Product Quality Product Enhancements Sunfiber (Partially Hydrolyzed Guar Gum) Sunfiber promotes intestinal and colon health, and aids in the transit of food through the intestines.*
More informationPRODUCT PROSPECTUS. Probiotics and Prebiotics
PRODUCT PROSPECTUS Probiotics and Prebiotics 2 PURITY POTENCY PERFORMANCE PROBIOTICS AND PREBIOTICS Table of Contents The Klaire Labs Story 4-5 Section 1: Probiotics Reference Guide 6-7 Section 2: Probiotics
More informationQ What are Probiotics?
Q What are Probiotics? The word PROBIOTIC was originated from Latin and means For Life. Probiotics are good bacteria usually found in food products or supplements which play very important roles in regulating
More informationHMF Probiotics PROFESSIONAL PRODUCT GUIDE
HMF Probiotics PROFESSIONAL PRODUCT GUIDE NEW New products inside Research-driven, proprietary, human-sourced strains Visit www.seroyal.com/genestrabrands to view the entire GENESTRA BRANDS line Dedicated
More informationProbiotics. Wide spectrum of important health benefits
Probiotics Part 1: What Are Probiotics? Probiotics are live microorganisms that inhabit the respiratory and gastrointestinal tracts and the skin. They are often referred to as friendly bacteria as they
More informationProbiotics and Health
Probiotics and Health March 2015 TABLE OF CONTENTS EXECUTIVE SUMMARY... 2 BACKGROUND AND DEFINITIONS... 4 FUNCTIONAL GASTROINTESTIINAL DISORDERS... 5 Irritable bowel syndrome... 5 Constipation... 6 INFLAMMATORY
More informationPROBIOTICS NEGATIVE ASPECTS
PROBIOTICS NEGATIVE ASPECTS Dr Ismail Moola Department of Medical Gastroenterology CMJAH University of Witwatersrand Putative Benefits of Probiotics Modulate Immune Intestinal Function Increase secretory
More informationLactobacillus bulgaricus
probiotic Lactobacillus bulgaricus Danone " : : * * * * * Bifidobacterium (LactobacillusCG) (Saccharomyce) (Bifidobacterium) (Antibiotic related diarrhea) GG L (Cytoprotection) B IgA lgg Probiotics -
More informationQuick Guide to Probiotics for Digestive Health
Quick Guide to Probiotics for Digestive Health The following are some commercially available probiotic single-strain or multi-strain products with evidence from human clinical trials (see references) for
More informationPROBIOTICS IN HUMAN NUTRITION. Agnieszka Chlebicz Katarzyna Śliżewska
PROBIOTICS IN HUMAN NUTRITION Agnieszka Chlebicz Katarzyna Śliżewska Źródła: [2, 11] What are probiotics? Live microorganisms which when administered in adequate amount confer a health benefits on the
More informationLinking Research to Clinical Practice
Probiotics and Oral Health Denise M. Bowen, RDH, MS Linking Research to Clinical Practice The purpose of Linking Research to Clinical Practice is to present evidence based information to clinical dental
More information11/2/2016. Objectives. Definition of probiotics. What is and what is not a probiotic? What is and what is not a probiotic?
A Consumer s Guide to Probiotics and Health Wellness Wednesday November 2, 2016 Wendy Dahl RD PhD FDC Associate Professor, Food Science and Human Nutrition, UF/IFAS Objectives To outline current evidence
More informationNext generation of probiotics
Session: Evaluating next generation ingredients to support digestive health Wednesday 23 rd November 2016 Next generation of probiotics Louise R Wilson RD PhD Assistant Science Manager, Yakult UK Ltd LWilson@yakult.co.uk
More informationSurvival of new probiotic strains with anti-inflammatory & anti-obesity effects used in non-fat yogurt and low-fat Cheddar cheese making
Survival of new probiotic strains with anti-inflammatory & anti-obesity effects used in non-fat yogurt and low-fat Cheddar cheese making Veronique Demers-Mathieu, Ph.D. Department of Microbiology & Medicine
More informationThe impact of the microbiome on brain and cognitive development
The Gut-Brain Axis The impact of the microbiome on brain and cognitive development Diane Stadler, PhD, RD Oregon Health & Sciences University, Portland, Oregon Lao-American Nutrition Institute With acknowledgements
More informationM I L L E R T H O M S O N LLP Barristers & Solicitors, Patent & Trade Mark Agents
M I L L E R T H O M S O N LLP Barristers & Solicitors, Patent & Trade Mark Agents Communiqué for Health Industry Clients on the Legal Retainer Program Canada s New Natural Health Products Regulations On
More informationProbiotic. Product Guide
Probiotic Product Guide Product Quality Product Enhancements Sunfiber (Partially Hydrolyzed Guar Gum) Single Dual Multi Blend 12B Sunfiber promotes intestinal and colon health, and aids in the transit
More informationDigestive Health. Sponsored by:
Digestive Health Sponsored by: Highlighting the key trends and future directions for innovation in the digestive health space Speaker: Robin Wyers, Chief Editor, Innova Market Insights (The Netherlands)
More informationAiro International Research Journal April, 2016 Volume VII, ISSN:
1 A STUDY ON ENZYMATIC ACTIVITIES WITH A REFERENCE OF Abstract SCREENING PROCEDURE CHANDRAMANI KUMAR RESEARCH SCHOLAR OF OPJS UNIVERSITY, CHURU (RAJ.) Increasing interest in health foods in recent years
More informationTowards a Sustainable Global Infrastructure for Medical Countermeasures
Towards a Sustainable Global Infrastructure for Medical Countermeasures Institute of Medicine The Public Health Emergency Medical Countermeasures Enterprise: Innovative Strategies to Enhance Products from
More informationFormulations and Availability 900 BILLION 5,319 HIGH POTENCY PROBIOTIC PEDIATRIC ADULT GERIATRIC PROVEN BY RESEARCH. HIGH-POTENCY. NO SHORTCUTS.
Formulations and Availability S TU D I E S PE R D I S E A S E 39 LIVER Liver Disease, Cirrhosis, Liver Failure, Hepatic Encephalopathy S TU D I E S PE R AG E G RO U P Visbiome Regular Product Code: 693-0412-01
More informationFonterra Probiotics: From guts to glory
Fonterra Probiotics: From guts to glory James Dekker April 16, 2015 Host Institution Probiotic bacteria Live micro-organisms which, when administered in adequate amounts, confer a health benefit on the
More informationPROBIOTIC PRODUCTS IN HORSES
ISAPP Open Forum, London UK, June 26-28, 2007 Royal College of Physicians Development of Probiotic strains for Equine Application Alexander Rodriguez-Palacios,* DVM, MSc, DVSc. DipACVIM - candidate Ontario
More informationDietary Supplements: Safe, Effective or Neither?
Dietary Supplements: Safe, Effective or Neither? KEEP YOUR EDGE Hockey Sports Medicine 2015 August 28, 2015 Dr. Ashley James, B.A., N.D. Naturopathic Doctor Disclosure I have no relevant non-financial
More informationcontinuing education for pharmacists Volume XXXIV, No. 8
continuing education for pharmacists Volume XXXIV, No. 8 Prebiotics, Probiotics, and Synbiotics: Their Therapeutic Role Cortney M. Mospan, PharmD, BCACP, CGP, Assistant Professor of Pharmacy, Wingate University
More informationSoftware as a Medical Device (SaMD)
Software as a Medical Device (SaMD) Clinical Evaluation IMDRF/SaMD WG (WD2)/N41R1: 2016 Bakul Patel, USA FDA Chair SaMD Working Group Scope NWIE Proposal - Software as a Medical Device (SaMD): Clinical
More informationULTIMATE FLORA PROBIOTICS
ULTIMATE FLORA PROBIOTICS In the Refrigerator Section! High-Potency Daily, Critical Care and Targeted Probiotic Formulas to Improve Regularity, Strengthen Natural Defenses and Promote Overall Digestion*
More informationJournal of Pharma Research
Journal of Pharma Research Research Article Available online through ISSN: 2319-5622 www.jprinfo.com Impact of Oral Administration of Lactobacillus Acidophilus and Bifidobacterium Lactis (Providac) on
More informationPrebiotics, probiotics and synbiotics: An update
Prebiotics, probiotics and synbiotics: An update Natalie Schellack Professor, School of Pharmacy, Sefako Makgatho Health Sciences University Yolanda Combrinck Former academic intern, School of Pharmacy,
More informationDID YOU KNOW. In Malaysia, colon cancer ranks as the 2nd commonest cancer.
Source: Malaysian National Cancer Registry Report (MNCR) 2007-2011 DID YOU KNOW. In Malaysia, colon cancer ranks as the 2nd commonest cancer. No. 1 cancer killer among Malaysian men and the second among
More informationGovernment Gazette Staatskoerant
Government Gazette Staatskoerant REPUBLIC OF SOUTH AFRICA REPUBLIEK VAN SUID AFRIKA Regulation Gazette No. 10177 Regulasiekoerant Vol. 629 14 November November 2017 No. 41248 N.B. The Government Printing
More informationMegaSporeBiotics Probiotics. Linda Wilbert - Stewart, FDN, HHP, HC 1/28/
MegaSporeBiotics Probiotics www.exclusivelyholistic.com Linda Wilbert - Stewart, FDN, HHP, HC 1/28/2015 111 MegaSporeBiotic is the first, all spore, carotenoid rich, probiotic consortium formulation on
More informationProbiotics: Targeting obesity
Probiotics: Targeting obesity Azadeh Nadjarzadeh, PhD in Nutrition Nutrition and Food Security Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran azadehnajarzadeh@gmail.com Among
More informationCancer preventive effects of lactic acid bacteria
TALAB Symposium 2007. 11. 9. National Taiwan Univ. Cancer preventive effects of lactic acid bacteria Hyong Joo Lee Seoul National University 1 Total deaths from cancer and heart disease J. Natl. Cancer
More informationProbiotics- basic definition
Haworth Press 2007 Probiotics Terms: Probiotic Probiotics are live microorganisms (bacteria or yeasts) which, when administered in adequate amounts, confer a health benefit on the host Prebiotic - nutritional
More information18 Week 92% Open Pathway Recovery Plan and Backlog Clearance
18 Week 92% Open Pathway Recovery Plan and Backlog Clearance Page 1 of 6 17.05.2012 1.0 Background 18-Week 92% Open Pathway RECOVERY PLAN The Trust has achieved compliance against the admitted and non-admitted
More informationFOOD CONTACT COATINGS --- A MANUFACTURER S PERSPECTIVE
FOOD CONTACT COATINGS --- A MANUFACTURER S PERSPECTIVE Presented to Mechanical Association Railcar Technical Services Conference September 17, 2009 By Madelyn K. Harding Senior Manager, Corporate Regulatory
More informationPROSPERO International prospective register of systematic reviews
PROSPERO International prospective register of systematic reviews The effect of probiotics on functional constipation: a systematic review of randomised controlled trials EIRINI DIMIDI, STEPHANOS CHRISTODOULIDES,
More informationProbiotics for Aquaculture
Probiotics for Aquaculture Seppo Salminen Functional Foods Forum University of Turku Finland Acquaculture Fish farming Carp and related fish are the most farmed fish (mainly in Asia) at 18,5 million metric
More informationCommercialisation of probiotics & commercial trends. Paul Mannion Director of Product innovation Blackmores
Commercialisation of probiotics & commercial trends Paul Mannion Director of Product innovation Blackmores OUR PURPOSE Blackmores improves people s lives by delivering the world s best natural health solutions.
More informationNatural and Holistic Medicine Approach in Evaluation and Treatment of Vaginal and Urinary Tract Health
Natural and Holistic Medicine Approach in Evaluation and Treatment of Vaginal and Urinary Tract Health By Dr. Michael John Badanek, BS, DC, CNS, CTTP, DACBN, DCBCN, MSGR./CHEV While the gut has an estimated
More informationProbiotics for Primary Prevention of Clostridium difficile Infection
Probiotics for Primary Prevention of Clostridium difficile Infection Objectives Review risk factors for Clostridium difficile infection (CDI) Describe guideline recommendations for CDI prevention Discuss
More informationEmerging Probiotic Research: A Guide to the Use of Probiotics in Clinical Practice
Emerging Probiotic Research: A Guide to the Use of Probiotics in Clinical Practice Donald Brown, ND April 13, 2010 Probiotics WHO Definition: Live microorganisms, which when administered in adequate amounts,
More informationThe importance of balance: Matching science with advocacy to encourage enlightened regulation. Dr Alex Y. Teo, Director of Scientific Affairs
The importance of balance: Matching science with advocacy to encourage enlightened regulation Dr Alex Y. Teo, Director of Scientific Affairs Presentation Overview I. Introduction II. Safety Standards &
More informationBest use of a probiotic supplement (Symprove TM )
UCL School of Pharmacy You ve got to be in it to win it Best use of a probiotic supplement (Symprove TM ) Professor Simon Gaisford s.gaisford@ucl.ac.uk @sgaisforducl Probiotics Probiotic market estimated
More informationWhich foods may carry nutrition and health claims? Update from EFSA
Which foods may carry nutrition and health claims? Update from EFSA Leng HENG Unit on Dietetic Products, Nutrition and Allergies (NDA) EFET Conference - 22 Oct 2010, Athens 1 2 Outline EFSA Panel on Dietetic
More information