EURL-SRM - Analytical Observations Report
|
|
- Flora Horton
- 6 years ago
- Views:
Transcription
1 cncerning the fllwing EURL-SRM - Analytical Observatins Reprt Cmpund(s): Pymetrzine Cmmdities: Varius cmmdities f plant rigin Methd(s): QuEChERS, adjustment f ph Instrumentatin: LC-MS/MS Analysis f Pymetrzine by the QuEChERS Methd - Impact f ph n Recvery Rate Reprted by: EURL-SRM Versin 1 (last update: ) Backgrund infrmatin / Initial Observatins: When using the citrate buffered QuEChERS methd (EN15662), recvery rates f pymetrzine are ften < 70 %, mstly in the range between 45 t 65 %. Sme examples are shwn in Table 1: Table 1: Recvery rates fr pymetrzine using citrate buffered QuEChERS (EN15662) Cucumber % 5 % Avcad % 10 % Wheat % 6 % Grapes % 4 % Lemn % 6 % Withut buffering, recvery rates are mre strngly influenced by the natural ph f the extracted cmmdities, with recveries frm neutral cmmdities like lettuce being higher than thse frm acidic nes. Pymetrzine, being weakly basic at the pyridine grup (pk a f the crrespnding acid ~4.4) and weakly acidic at the triazinne grup (pk a ~11.4), exhibits an ambiphilic character 1. At ph values < 4.4 the prtnated frm predminates. At ph values <2 even a duble prtnated frm cmes int play (pk a ~0.7 at the triazinn grup). As the ph decreases the lgd value (a measure f lipphilicity) drps frm ~-0.25 at ph 5 t ~-0.5 at ph 4 and further t ~-0.7 at ph 3. This explains the lwer recvery rates at lwer ph. 1 pka values calculated by in the EFSA peer review n pymetrzine ( the pka is given as 4.06 Page 1
2 Between ph 6 and 10 pymetrzine is almst exclusively present in its - still quite plar - neutral frm (lgp ~ -0.2), and has a mre favrable transfer int the acetnitrile phase. Using the citrate buffering salts f EN the ph value during extractin is arund 4. Althugh the citrate salt mixture in itself buffers in the ph range f 5-5.5, the presence f MgSO 4 causes the ph t drp as Mg 2+ ins frm a cmplex with citrate, thus releasing prtns. As a result the recvery f pymetrzine remains well belw 70%. Facts at a glance: Pymetrzine Mde f actin Lg D Insecticide selective against Hmptera like aphids and whiteflies [1] Partitin cefficient lg P/w = (ph 5, 25 C) lg P/w = (ph 7, 25 C) lg P/w = (ph 9, 25 C) [3] 320 mg/l (25 C; ph 5) 270 mg/l (25 C; ph 7) 270 mg/l (25 C; ph 9), all 99.7% [3] Water slubility Dissciatin cnstant Residue definitin EU Registratin Status ADI 0.03 mg/kg bw/day [3] ARfD 0.1 mg/kg bw [3] pka,1 = 4.06 (basic, prtnatin at nitrgen atm f the pyridine ring) [1,3] pka,2 < 1 (basic, prtnatin at nitrgen atm f triazinne ring) [1,3] pka,3 = 11.4 (acidic, deprtnatin at nitrgen f triazinne ring) [chemicalize.rg] Pymetrzine Fr milk: pymetrzine, 6-hydrxymethylpymetrzine and its phsphate cnjugate, expressed as pymetrzine [2] Apprved within the EU: AT, BE, CY, CZ, DE, DK, EE, EL, ES, FI, FR, HR, HU, IE, IT, LT, LU, LV, NL, PL, PT, RO, SE, SI, UK Page 2
3 Observatins and experiments cnducted: Materials and instrumentatin (exemplary 2 ): Pymetrzine (purity 99.9%), purchased frm Riedel-de-Haen (stck slutin at 1 mg/ml was prepared in methanl) Magnesium acetate tetrahydrate, min. 99% frm Sigma-Aldrich Sdium acetate p.a. anhydrus, min. 99% frm Merck Table 2: Instrumentatin details LC Agilent 1290 MS/MS ABSCIEX 4000, run in ESI psitive mde MRMs / (target); / 78.0 (qualifier) Clumn Phenmenex Synergi 4 µ Hydr-RP; 150x2 mm Pre-clumn Aqua C18 125A 4 mm x 2 mm Mbile Phase A: 5 mml NH 4 -frmiate in purified H2O withut additin f methanl (use brwn bttles t avid frmatin f algae) B: 5 mml NH 4 frmate in methanl Gradient Mbile Phase A Mbile Phase B Flw Time (min) (%) (%) (ml/min) Clumn temperature 40 C Injectin vlume 3 µl, autmatically diluted with 10 µl f mbile phase A during injectin prcedure Internal Standard Nte: Shuld the pssibility fr an autmated dilutin f the slutins in the instrument injectr nt exist, the sample extracts shuld be manually diluted with mbile phase A (e.g. 1+1 t 1+4) Chlrpyrifs-ethyl D10 Direct injectin f QuEChERS extracts nt traditinal C-18 clumns ften results in peak distrtin r even splitting. Diluting the extracts with the aqueus mbile phase A prir r during injectin, imprves the situatin. The use f gradients starting with highly aqueus eluent cmpsitin facilitates reversed phase interactins f highly plar cmpunds such as pymetrzine with the statinary phase. Plar end-capped RP clumns are helpful in this respect as they can tlerate purely aqueus eluents withut the hydrcarbn-chains cllapsing. 2 Disclaimer: Names f cmpanies are given fr the cnvenience f the reader and d nt indicate any preference by the EURL-SRM twards these cmpanies and their prducts Page 3
4 Impact f extractin ph n pymetrzine recveries T study the influence f varius salt mixtures n the ph varius cmbinatins f salts (used instead the citrate buffering salts described in EN15662) were tested using cucumber as neutral and range juice as acidic cmmdity: The resulting ph values in the extracts are shwn in Table 3. Table 3: ph values f QuEChERS extracts using different buffering salt cmbinatins Orange juice Cucumber Orange juice Cucumber Citrate buffering salts EN % 65 % 4 g MgSO 4. 1 g NaCl % 80 % 4 g MgSO 4. 1 g NaCl. 0.5 g Na-Acetate % 86 % 4 g MgSO g Mg-Acetate Nt analyzed Nt analyzed 4 g MgSO 4. 1 g Mg-Acetate % 97 % The resulting ph values indicate that magnesium r sdium acetate is necessary t elevate the ph value f acidic cmmdities abve ph=5 in rder t ensure that pymetrzine lays almst entirely in its less plar neutral frm. The recveries achieved with the different variatins are shwn belw: Table 4: Recvery figures fr pymetrzine using different QuEChERS salt cmpsitins (Chlrpyrifs D10 was used as internal standard) Frtificatin level 0.1 mg/kg (n=5) Recvery % CV % Recvery % CV % 4 g MgSO 4, 1 g Mg-Acetate g MgSO 4, 0.5 g Na-Acetate, 1 g NaCl Using 10 ml water and the salt mixtures listed abve, the vlume f the rganic phase was measured. In the case f 4 g MgSO g Mg-Acetate the vlume f the rganic phase was 10.8 ml and in the case f 4 g MgSO g Na-Acetate + 1 g NaCl it was 10.0 ml. In principle, such vlume deviatins can be cmpensated by internal standards, hwever if n internal standard is used the secnd ptin is favred. T prve that the pr recveries f pymetrzine are nt due t degradatin range juice was spiked and extracted a) immediately and b) after 1 hur delay. The mean recveries did nt decrease indicating that pymetrzine is nt particularly sensitive t degradatin at lw ph. Page 4
5 Overall Cnclusins: Pymetrzine shws ph-dependent recvery rates using the QuEChERS methd. ph shuld ptimally exceed 5 fr the pymetrzine recvery rates t be well abve 70%. ph can be increased by replacing the citrate salts with acetate salts. The fllwing mixtures were fund t wrk well fr 10 g sample: 4 g MgSO 4 +1 g NaCl g sdium acetate and 4 g MgSO 4 +1 g Mg-Acetate. [1] The Pesticide Manual 14 th Editin. C D S Tmlin. BCPC 2006 [2] Regulatin (EU) 2015/401 [3] EFSA Jurnal 2014;12(9):3817. Cnclusin n the peer review f the pesticide risk assessment f the active substance pymetrzine Histry Actin When Versin Cnductin f experiments June 2015 February 2016 Methd placed n-line April 2016 V1 Page 5
Matrix-induced Signal Enhancement of Propamocarb in LC-MS/MS
Observations concerning a compound a matrix a method other Matrix-induced Signal Enhancement of Propamocarb in LC-MS/MS Reported by: EURL-SRM Version 1 (last update: 24.10.2012) Brief description of problem/observation/solution:
More informationEURL-SRM - Analytical Observations Report
concerning the following EURL-SRM - Analytical Observations Report o Compound(s): AMTT (metabolite of tritosulfuron) o Commodities: Fruit and vegetables, cereals o Extraction Method(s): o Instrumental
More informationMETHOD 8032 ACRYLAMIDE BY GAS CHROMATOGRAPHY
METHOD 8032 ACRYLAMIDE BY GAS CHROMATOGRAPHY 1.0 SCOPE AND APPLICATION 1.1 Methd 8032 is used t determine trace amunts f acrylamide mnmer in aqueus matrices. This methd may be applicable t ther matrices.
More informationEURL-SRM - Analytical Method Report. Analysis of Residues of Carbofuran (sum) Using QuEChERS Method
EURL-SRM - Analytical Method Report Analysis of Residues of Carbofuran (sum) Using QuEChERS Method Reported by: EURL-SRM Version (last update: 20.04.206) Brief description: A QuEChERS-based method for
More informationAnalysis of Pyridate and its metabolite Pyridafol by QuEChERS and LC-MS/MS
Observations concerning a compound a matrix a method other Analysis of Pyridate and its metabolite Pyridafol by QuEChERS and LC-MS/MS Reported by: EURL-SRM Version 1 (last update: 30.03.2015) Brief description
More informationAnalysis of Organotin-Pesticides by the QuEChERS Method - Impact of acidifying on the recoveries
Observations concerning a compound a matrix a method other Analysis of Organotin-Pesticides by the QuEChERS Method - Impact of acidifying on the recoveries Reported by: EURL-SRM Version 1 (last update:
More informationEURL-SRM - Analytical Observations Report
concerning the following EURL-SRM - Analytical bservations Report o Compound(s): Boscalid metabolite M510F01, Fenpropidin metabolite CGA289267 Isoxaflutole metabolite RPA202248 Isoxaflutole metabolite
More informationAnalysis of Pesticide Residues in Citrus Oils by GCxGC-TOFMS with Minimal Sample Preparation
Analysis f Pesticide Residues in Citrus Oils by GCxGC-TOFMS with Minimal Sample Preparatin LECO Crpratin; Saint Jseph, Michigan USA Key Wrds: GCxGC-TOFMS, Classificatins, Decnvlutin, Quantificatin, Sample
More informationChapter 21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions
Chapter 21: Carbxylic Acid Derivatives: Nuclephilic Acyl Substitutin Reactins 21.1 Naming Carbxylic Acid Derivatives Naming Acid Halides, RCOX Naming Acid Anhydrides, RCO 2COR Naming Esters, RCO 2R 1.
More informationChem 464 Biochemistry Third Hour Exam
Name: Chem 464 Bichemistry Third Hur Exam Multiple chice (5 pints apiece): 1. Which f the fllwing statements cncerning fatty acids is crrect? A) One is the precursr f prstaglandins. B) Phsphatidic acid
More informationExtraction of oleic acid from jojoba oil, soybean oil and olive oil Phase diagrams
IndianJurnalfChemicalTechnlgy Vl.3, Nvember1996,pp. 299-305 Extractin f leic acid frm jjba il, sybean il and live il Phase diagrams JaimeWisniak*,AlexanderApelblat&Ahu-AkelKhaled epartmentfchemicalengineering,ben-gurianuniversityf
More informationEURL-SRM - Analytical Observations Report
EURL-SRM - Analytical Observations Report concerning the following o Compound(s): Carbofuran, Benfuracarb, Carbosulfan, Furathiocarb, 3-Hydroxy-Carbofuran o Commodities: Various commodities of plant origin
More informationProtocol. Preparation Protocol for the Non-Targeted Vevo MicroMarker Contrast Agent
Prtcl Preparatin Prtcl fr the Nn-Targeted Vev MicrMarker Cntrast Agent System Cmpatibility: This guide cntains instructins and suggestins fr wrk n the Vev2100, VevLAZR, Vev 3100 systems and transducers
More informationFDA Dietary Supplement cgmp
FDA Dietary Supplement cgmp FEBRUARY 2009 OVERVIEW Summary The Fd and Drug Administratin (FDA) has issued a final rule regarding current gd manufacturing practices (cgmp) fr dietary supplements that establishes
More informationAction plan: serialisation of Nordic packages focus on Product Codes
19.6.2017, versin 5 Actin plan: serialisatin f Nrdic packages fcus n Prduct Cdes The aim f this dcument is t help pharma cmpanies t prepare fr prduct cde changes and t be able t maintain prduct cdes in
More informationABIOpure TM Total RNA (version 2.0)
ABIOpure TM Ttal RNA (versin 2.0) Bld Extractin Handbk Cat N: M541RP50-B FOR RESEARCH USE ONLY Table f Cntents Cntents Page Kit Cmpnents 3 Precautins 3 Stability & Strage 4 General Descriptin 4 Limitatins
More informationSQA-VISION VALIDATION REPORT
Objective SQA-VISION VALIDATION REPORT T test the new cnvenience features f the SQA-Visin vs. the SQA-V and manual semen assessment: Swim-up Density Gradient Lngevity Vitality Mrphlgy Cunter Scanning Debris/Rund
More informationEXPLORING THE PROCESS OF ASSESSMENT AND OTHER RELATED CONCEPTS
1 SECTION 1 INTRODUCTION: EXPLORING THE PROCESS OF ASSESSMENT AND OTHER RELATED CONCEPTS The Nature Of Assessment The Definitin Of Assessment The Difference Between Testing, Measurement And Evaluatin Characteristics
More informationPart 3. Monoenoic Fatty Acids
MASS SPECTRA OF METHYL ESTERS OF FATTY ACIDS Part 3. Mnenic Fatty Acids As cautined in the Intrductin t these dcuments, the mass spectra f methyl esters btained with electrn-impact inizatin ften affrd
More informationRate Lock Policy. Contents
Rate Lck Plicy Cntents Rate Lcks... 2 Rate Lck Cnfirmatin... 2 Lck Term... 2 Pre-Lck... 2 Maximum Qualified Rate... 3 Extensins... 3 Cst t Extend... 3 Relcks... 4 Re-Negtiatin r Flat Dwn Plicy... 4 Prgram
More informationAssessment Field Activity Collaborative Assessment, Planning, and Support: Safety and Risk in Teams
Assessment Field Activity Cllabrative Assessment, Planning, and Supprt: Safety and Risk in Teams OBSERVATION Identify a case fr which a team meeting t discuss safety and/r safety planning is needed r scheduled.
More informationPROTOCOL 1850 Millrace Drive, Suite 3A Eugene, Oregon
PROTOCOL Cmplex II Enzyme Activity Micrplate Assay Kit 1850 Millrace Drive, Suite 3A Eugene, Oregn 97403 MS241 Rev.0 DESCRIPTION Cmplex II Enzyme Activity Micrplate Assay Kit Sufficient materials are prvided
More informationPACT premier TM HT-96 MD1-36 PACT premier is a ph, Anion, Cation crystallization trial devised to test ph within a PEG/Ion screen.
PACT premier TM HT-96 MD1-36 PACT premier is a ph, Anin, Catin crystallizatin trial devised t test ph within a PEG/In screen. MD1-36 cntains 96 x 1 ml reagents in a deep-well blck. Features f PACT premier
More informationBIOLOGY 101. CHAPTER 7: Membrane Structure and Function: Life at the Edge
BIOLOGY 101 CHAPTER 7: Membrane Structure and Functin: Life at the Edge Membrane Structure and Functin: Life at the Edge CONCEPTS: 7.1 Cellular membranes are fluid msaics f lipids and prteins 7.2 Membrane
More informationCONSENT FOR KYBELLA INJECTABLE FAT REDUCTION
CONSENT FOR KYBELLA INJECTABLE FAT REDUCTION INSTRUCTIONS This is an infrmed cnsent dcument which has been prepared t help yur Dctr infrm yu cncerning fat reductin with an injectable medicatin, its risks,
More informationMASS SPECTRA OF DERIVATIVES OF CYCLOPROPYL AND CYCLOPROPENYL FATTY ACIDS
MASS SPECTRA OF DERIVATIVES OF CYCLOPROPYL AD CYCLOPROPEYL FATTY ACIDS The dcument des nt aim t be a cmplete accunt f mass spectrmetry f cyclprpyl and cyclprpenyl fatty acids, but rather is a persnal accunt
More informationP02-03 CALA Program Description Proficiency Testing Policy for Accreditation Revision 1.9 July 26, 2017
P02-03 CALA Prgram Descriptin Prficiency Testing Plicy fr Accreditatin Revisin 1.9 July 26, 2017 P02-03 CALA Prgram Descriptin Prficiency Testing Plicy fr Accreditatin TABLE OF CONTENTS TABLE OF CONTENTS...
More informationThis clinical study synopsis is provided in line with Boehringer Ingelheim s Policy on Transparency and Publication of Clinical Study Data.
abcd Clinical Study Synpsis fr Public Disclsure This clinical study synpsis is prvided in line with Behringer Ingelheim s Plicy n Transparency and Publicatin f Clinical Study Data. The synpsis which is
More informationVITAPRO. Detoxification properties of Apple pectin formulation, PROPECTIN. CENTRE D ETUDE ET DE VALORISATION DES ALGUES FINAL REPORT.
CENTRE D ETUDE & DE VALORISATION DES ALGUES 2400 Detxificatin prperties f Apple pectin frmulatin, PROPECTIN. VITAPRO FINAL REPORT PrPectin July 2015 CENTRE D ETUDE ET DE VALORISATION DES ALGUES PRESQU
More informationUSING THE POLARITY CHARACTERISTICS OF A DRUG S FUNCTIONAL GROUPS TO ESTIMATE SOLUBILITY CHARACTERISTICS
USING THE POLARITY CHARACTERISTICS OF A DRUG S FUNCTIONAL GROUPS TO ESTIMATE SOLUBILITY CHARACTERISTICS Lessn Objectives 1. Understand what is meant by lgp; knw the difference between MlgP and ClgP 2.
More informationAP Biology Lab 12: Introduction to the Scientific Method and Animal Behavior
Name: AP Bilgy Lab 12: Intrductin t the Scientific Methd and Animal Behavir Overview In this lab yu will: -Observe an rganism and design an experiment t investigate their respnses t envirnmental variables.
More informationALCAT FREQUENTLY ASKED QUESTIONS
1. Is fasting required befre taking the Alcat Test? N. It is recmmended t drink water and t avid stimulants like caffeine prir t the test. 2. With regard t testing children, must a child be a certain age
More informationMASS SPECTRA OF DERIVATIVES OF ALICYCLIC FATTY ACIDS WITH 5- AND 6-MEMBERED RINGS
MASS SPECTRA OF DERIVATIVES OF ALICYCLIC FATTY ACIDS WITH 5- AD 6-MEMBERED RIGS The dcument des nt aim t be a cmplete accunt f mass spectrmetry f all cyclic fatty acids, but rather is a persnal accunt
More informationACMPR - Access to Cannabis for Medical Purposes Regulations Part 1 Commercial Production
- Access t Cannabis fr Medical Purpses Regulatins Part 1 Cmmercial Prductin September 2017 OVERVIEW Yu must cmply with regulatins t supply medical cannabis as f August 24, 2016 There are fur parts t the
More informationSpecifically, on page 12 of the current evicore draft, we find the statement:
Octber 23, 2016 evicre Healthcare Attn: Dr Greg Allen 400 Buckwalter Place Bulevard Blufftn, SC 29910 RE: evicre Draft Onclgy Imaging Guidelines, v 19.0 Gentlepersns: Prstate Cancer Internatinal is a nt-fr-prfit
More informationCSE 331, Spring 2000
YOUR NAME: SECTION NUMBER: CSE 331, Spring 2000 Class Exercise 15 Algrithm Design Techniques-Greedy Algrithms March 13, 2000 Fllwing are five f the cmmn types f algrithms. Fr many prblems it is quite likely
More informationFor Research Use Only Ver
INSTRUCTION MANUAL Quick-cfRNA Serum & Plasma Kit Catalg N. R1059 Highlights High-quality cell-free RNA is easily and rbustly purified frm up t 3 ml f plasma, serum, r ther bilgical fluids. Purified cell-free
More informationEDPS 475: Instructional Objectives for Midterm Exam Behaviorism
EDPS 475: Instructinal Objectives fr Midterm Exam Behavirism 1. Given a nvel example t chse frm, identify the characteristics f classical cnditining. General mdel: Stimulus (S) elicits >Respnse (R) Based
More informationTABLE OF CONTENTS Glossary of terms Code Pad Diagram 3. Understanding the Code Pad lights.4.
TABLE OF CONTENTS... Glssary f terms 2... Cde Pad Diagram 3 Understanding the Cde Pad lights.4 Cde Pad tnes 5 Fully arming the system - ON MODE 6 Fully arming the system - Quick Arm MODE 6 Partially arming
More informationMonensin and Extruded Urea-Grain for Range Beef Cows
Mnensin and Extruded Urea-Grain fr Range Beef Cws R. P. Lemenager, F. N. Owens, w. E. Sharp, Merwin Cmptn and Rbert Ttusek Stry in Brief Tw trials were cnducted t evaluate the supplemental value f mnensin
More informationHow to Get Set Up and Running with NDepend
Hw t Get Set Up and Running with NDepend Whether yu have purchased r dwnladed the trial f NDepend, we thank yu fr yur invlvement and interest in ur prduct. Here we have cmpiled a quick "Getting Started"
More information2017 PEPFAR Data and Systems Applied Learning Summit Day 2: MER Analytics/Available Visualizations, Clinical Cascade Breakout Session TB/HIV EXERCISE
2017 PEPFAR Data and Systems Applied Learning Summit Day 2: MER Analytics/Available Visualizatins, Clinical Cascade Breakut Sessin TB/HIV EXERCISE Created by the ICPI TB/HIV Wrkstream Abut this Handut
More informationDATA RELEASE: UPDATED PRELIMINARY ANALYSIS ON 2016 HEALTH & LIFESTYLE SURVEY ELECTRONIC CIGARETTE QUESTIONS
DATA RELEASE: UPDATED PRELIMINARY ANALYSIS ON 216 HEALTH & LIFESTYLE SURVEY ELECTRONIC CIGARETTE QUESTIONS This briefing has been specifically prepared fr the Ministry f Health t prvide infrmatin frm this
More informationEMC believes the information in this publication is accurate as of its publication date. The information is subject to change without notice.
EMC DATA PROTECTION ADVISOR (DPA) MIGRATION TECH NOTE With SQL as external database fr t 5.5.1 and later DPA versin 5.x releases t 6.0 SP1 and later ABSTRACT This Tech Nte prvides the steps t migrate frm
More informationEffects of compost maturity on growth of komatsuna (brassica rapa var. pervidis) in neubauer's pot
Sil Science and Plant Nutritin ISSN: 0038-0768 (Print) 1747-0765 (Online) Jurnal hmepage: https://www.tandfnline.cm/li/tssp20 Effects f cmpst maturity n grwth f kmatsuna (brassica rapa var. pervidis) in
More informationInitial Postoperative Knee Care Patella or Quadriceps Tendon Repairs: - Videos are available on Dr. Witty s website: drjeffreywitty.
Initial Pstperative Knee Care Patella r Quadriceps Tendn Repairs: - Vides are available n Dr. Witty s website: drjeffreywitty.cm Imprtant Phne Numbers: - Please see the cntact infrmatin abve fr imprtant
More informationICT4LIFE. Final Conference. ICT4Life field work - tailored solutions in diverse regional context Ariane Girault, E-Seniors Association
ICT4LIFE Final Cnference ICT4Life field wrk - tailred slutins in diverse reginal cntext Ariane Girault, E-Senirs Assciatin 10/22/2018 1 Why a field wrk with users in a research prject? The bjectives f
More informationThe demonstration of lysosomes by the controlled temperature freezing-sectioning method By LUCILLE BITENSKY
205 The demnstratin f lyssmes by the cntrlled temperature freezing-sectining methd By LUCILLE BITESKY (Frm the Department f Pathlgy, Ryal Cllege f Surgens f England, Lincln's Inn Fields, Lndn, W.C. 2)
More informationdetailed in Ward and Lockhead (1970), is only summarized here.
Respnse system prcesses in abslute judgment* LAWRENCE M. WARDt and G. R. LOCKHEAD Duke University, Durham, Nrth Carlina 2778 Cnsistent relatinships are fund between Ss' abslute judgments f the value f
More informationPart 1. Saturated and Branched-Chain Fatty Acids
Mass spectra f DMX derivatives. Part 1. Saturated and branched-chain fatty acids MASS SPECTRA F DMX DERIVATIVES Part 1. Saturated and Branched-Chain Fatty Acids a 4,4-Dimethylxazline (DMX) derivatives
More informationRugby Nutrition: Achieving Body Composition Goals Practice Tips
www.bksmart.cm /BkSmart @BkSmart Rugby Nutritin: Achieving Bdy Cmpsitin Gals Practice Tips Whether yu need t increase r maintain high levels f muscle mass fr strength and pwer, and/r if yu need t lse r
More informationGSB of EDA Meeting Minutes
Hell Everyne! We held a General Service Bard meeting n 04/10/2013. Attendees: Alita, British Clumbia, CAN Annette H, Phenix, AZ Fran, IL Rachel F, Tempe, AZ Rger, MA Vanessa S, Lngwd, FL Ntes: Rger asked
More informationPart 5. Trienoic Fatty Acids
MASS SPECTRA OF METHYL ESTERS OF FATTY ACIDS Part 5. Trienic Fatty Acids As cautined in the Intrductin t these dcuments, the mass spectra f methyl esters btained under electrn-impact inizatin affrd limited
More informationAccounting Assessment Report
Accunting 2014-2015 Assessment Reprt 1. Please give a brief verview f the assessment data yu cllected this year. This can be in any frm yu feel is apprpriate, such as a table, a shrt narrative f results,
More informationIndirect Sales. Proof Policy. Indirect Channel. Version May Author: Credit Risk & Fraud. External version
Prf Plicy Indirect Channel Versin 12 7 May 2015 Authr: Credit Risk & Fraud External versin 1 Table f Cntents Intrductin... 3 Distance Selling... 4 Face t Face Selling... 10 Additinal Prfs Plicy Infrmatin...
More informationSCALES NW HEARING PROTECTION PROGRAM
PURPOSE Expsure t excessive nise in the wrkplace can cause permanent hearing lss. The Hearing Prtectin Prgram has been established t help ensure that emplyees f Scales NW, Inc. d nt suffer health effects
More informationGUIDANCE DOCUMENT FOR ENROLLING SUBJECTS WHO DO NOT SPEAK ENGLISH
GUIDANCE DOCUMENT FOR ENROLLING SUBJECTS WHO DO NOT SPEAK ENGLISH Aurra Health Care s Research Subject Prtectin Prgram (RSPP) This guidance dcument will utline the prper prcedures fr btaining and dcumenting
More informationInfluence of Endosperm Type On the Nutritive Value Of Grain Sorghum and Corn
Influence f Endsperm Type On the Nutritive Value Of Grain Srghum and Crn c. A. Hibberd, R. Schemm and D. G. Wagner Stry in Brief The nutritive value f several varieties f grain srghum and crn was studied
More informationThe estimator, X, is unbiased and, if one assumes that the variance of X7 is constant from week to week, then the variance of X7 is given by
ESTIMATION PROCEDURES USED TO PRODUCE WEEKLY FLU STATISTICS FROM THE HEALTH INTERVIEW SURVEY James T. Massey, Gail S. Pe, Walt R. Simmns Natinal Center fr Health Statistics. INTRODUCTION In April 97, the
More informationA MORE HUMAN APPROACH TO INNOVATION RESEARCH 2
A MORE HUMAN APPROACH TO INNOVATION RESEARCH 2 INTRODUCTION Successful innvatin f cnsumer prducts and services relies n the ideas and feedback f real peple. Each persn has unique skills and abilities that
More informationImplementation Report on the patient safety Recommendation 2009/C 151/01. Healthcare Systems Unit DG SANCO
Implementation Report on the patient safety Recommendation 2009/C 151/01 Healthcare Systems Unit DG SANCO Published 15 November 2012 REPORT FROM THE COMMISSION TO THE COUNCIL on the basis of Member States'
More informationMeaningful Use Roadmap Stage Edition Eligible Hospitals
Meaningful Use Radmap Stage 1-2011 Editin Eligible Hspitals CPSI is dedicated t making yur transitin t Meaningful Use as seamless as pssible. Therefre, we have cme up with a radmap t assist yu in implementing
More informationImmunisation and Disease Prevention Policy
Immunisatin and Disease Preventin Plicy Quality Area 2: Children s Health and Safety 2.1 Each child s health is prmted 2.1.4 Steps are taken t cntrl the spread f infectius diseases and t manage injuries
More informationCall for evidence on the use of skin sensitisers, skin irritants and corrosive substances in textile and leather articles, hides and furs
Call fr evidence n the use f skin sensitisers, skin irritants and crrsive substances in textile and leather articles, hides and furs Backgrund dcument Backgrund Prductin and prcessing f textile and leather
More informationBreast Cancer Awareness Month 2018 Key Messages (as of June 6, 2018)
Breast Cancer Awareness Mnth 2018 Key Messages (as f June 6, 2018) In this dcument there are tw sectins f messages in supprt f Cancer Care Ontari s Breast Cancer Awareness Mnth 2018: 1. Campaign key messages
More informationA foot x-ray series is required only if there is pain in the midfoot zone and any one of the following:
RADIOGRAPHY OF THE ANKLE AND FOOT (OTTAWA ANKLE RULES) Clinical Practice Guideline January 2007 This guideline has been adapted frm the Ottawa Ankle Rules develped by Dr. Ian Stiell et al. Dr. Stiell received
More informationHerbal Medicines: Traditional Herbal Registration
Herbal Medicines: Traditinal Herbal Registratin In the UK, cmpanies can nly sell herbal medicines with the apprpriate prduct licence, as fllws: A full marketing authrisatin based n the safety, quality
More informationHow to become an AME Online
Hw t becme an AME Online 1. Check that yu meet the minimum technical requirements in rder t use the AME Online system: Operating System: Windws Vista (Service Pack 2) Windws 7 Windws 8, 8.1 Windws 10 Please
More informationHearing Conservation Program
Hearing Cnservatin Prgram FOREWORD Nise-induced hearing lss (NIHL) is a permanent and irreversible ccupatinal illness due t expsure t excessive nise. The Occupatinal Safety and Health Administratin (OSHA)
More informationNewborn screening in some European Countries. François Macary : cochair of IHE Laboratory Committee
LAB Newbrn screening in sme Eurpean Cuntries Françis Macary : cchair f IHE Labratry Cmmittee 1. Intrductin This dcument prduced by the IHE Labratry Cmmittee studies the prcess f newbrn screening in France,
More informationPart 1. Nicotinate Derivatives
Mass spectra f fatty alchls. Part 1. ictinate derivatives. MASS SPECTRA OF FATTY ALCOHOLS Part 1. ictinate Derivatives Fatty alchls can be characterized by GC-MS mst readily as the nictinate derivatives,
More informationWCPT awards programme 2015
WCPT awards prgramme 2015 The WCPT awards prgramme recgnises utstanding cntributins and leadership by individual physical therapists and grups t the prfessin and/r glbal health at an internatinal level.
More informationTrust Guideline for Urgent Brain Imaging and Management of Suspected Subarachnoid Haemorrhage
A Clinical Guideline Fr Use in: Accident & Emergency, Acute Medical Unit, Medical wards By: Medical staff Fr: Adult patients presenting with suspected subarachnid haemrrhage Divisin respnsible fr dcument:
More informationLecture 9 PCL201 Drug Distribution
Lecture 9 PCL201 Drug Distributin Where d drugs distribute? Drug distributin (and ptentially cncentratin) will depend n bld flw and the physichemical prperties f the chemical Lipid and water slubility
More informationGeneric Immunosuppressants in the Specialist Area of Transplantation Consensus on Implications and Practical Recommendations
Dear Clleague Generic Immunsuppressants in the Specialist Area f Transplantatin Cnsensus n Implicatins and Practical Recmmendatins Executive Summary Slid-rgan transplants are the best pssible treatment
More informationYou may have a higher risk of bleeding if you take warfarin sodium tablets and:
MEDICATION GUIDE Warfarin (WAR-far-in) Sdium (SO-dee-um) Tablets USP The 7.5 mg tablets cntain FD&C Yellw N. 5 (tartrazine), which may cause allergic-type reactins (including brnchial asthma) in certain
More informationA Unified Approach to Conflict Mineral Compliance for the Tungsten Industry. The Westin, Sydney, 23 September 2013
A Unified Apprach t Cnflict Mineral Cmpliance fr the Tungsten Industry The Westin, Sydney, 23 September 2013 Backgrund Cmpliance f public US dwnstream tungsten users with the reprting requirements f the
More informationHEALTH SURVEILLANCE INDICATORS: CERVICAL CANCER SCREENING. Public Health Relevance. Highlights.
HEALTH SURVEILLANCE INDICATORS: CERVICAL CANCER SCREENING Public Health Relevance Cervical cancer is 90% preventable by having regular Papaniclau (Pap) tests. The Pap test, als knwn as a cervical smear,
More informationQ 5: Is relaxation training better (more effective than/as safe as) than treatment as usual in adults with depressive episode/disorder?
updated 2012 Relaxatin training Q 5: Is relaxatin training better (mre effective than/as safe as) than treatment as usual in adults with depressive episde/disrder? Backgrund The number f general health
More informationChapter 17 Acids and Bases (same as Exam 2 Worksheet Answers)
xam 3 Wrksheet Answers xam 3 Wrksheet Answers Chemistry 4 Chapter 17 Acids and Bases (same as xam Wrksheet Answers) 1. Fr the weak acids, what is the pk a and rank the acids accrding t strength? 4.74 6.38;.3
More information2018 Medical Association Poster Symposium Guidelines
2018 Medical Assciatin Pster Sympsium Guidelines Overview The 3 rd Annual student-run Medical Assciatin f the State f Alabama Research Sympsium will take place n Friday and Saturday, April 13-14 at the
More informationM.J. Guthriel, D.G. Wagner2
EFFECT OF SUPPLEMENTAL PROTEIN OR GRAIN ON INTAKE AND UTILIZATION OF MEDIUM QUALITY PRAIRIE HAY BY STEERS M.J. Guthriel, D.G. Wagner2 and D.C. Weakley3 Stry in Brief Sixteen 1,053 lb tw-year-ld Herefrd
More informationPET FORM Planning and Evaluation Tracking ( Assessment Period)
Divisin f: Behaviral Studies PET FORM Planning and Evaluatin Tracking (2010 2011 Assessment Perid) Persn Respnsible fr this Divisin: Jerry Mller Department f: Behaviral Sciences Persn Respnsible fr this
More informationDIRECTED FORGETIING: SHORT-TERM MEMORY OR CONDITIONED RESPONSE? WENDY S. MILLER and HARVARD L. ARMUS The University of Toledo
The Psychlgical Recrd, 1999, 49, 211-220 DIRECTED FORGETIING: SHORT-TERM MEMORY OR CONDITIONED RESPONSE? WENDY S. MILLER and HARVARD L. ARMUS The University f Tled Previus researchers have interpreted
More informationThe Effects of the Electroejaculation Procedure on Sperm. Motility
Paraplegia 27 (1989) 45-49 0031-1758/89/0027-045$10.00 :C' 1989 Internatinal Medical Sciety f Paraplegia The Effects f the Electrejaculatin Prcedure n Sperm. Mtility T. Linsentneyer, MD,! C. Wiltnt, MD,t
More informationReference: Patient A. Brenda WXXXXX Date of Birth: 4/15/57
Reference: Patient A Brenda WXXXXX Date f Birth: 4/15/57 49 year ld white female patient presented n July 20, 2006 with chief cmplaint f stage 4 cancer, initially diagnsed in Octber, 2003 with Cervical
More informationRelated Policies None
Medical Plicy MP 3.01.501 Guidelines fr Cverage f Mental and Behaviral Health Services Last Review: 8/30/2017 Effective Date: 8/30/2017 Sectin: Mental Health End Date: 08/19/2018 Related Plicies Nne DISCLAIMER
More informationThe Effects of American Ginseng Extracts on Streptozocin Induced Diabetic Sciatic Neuropathy in Exercised Sprague Dawley Rats
The Effects f American Ginseng Extracts n Streptzcin Induced Diabetic Sciatic Neurpathy in Exercised Sprague Dawley Rats By Guangyu Li Supervisr: Dr. Earl Nble Agenda Backgrund Hypthesis Experimental design
More informationField Epidemiology Training Program
Field Epidemilgy Training Prgram Cancer Curriculum: Principles f Cancer Registries Case Study: Hspital-Based Cancer Registries FACILITATOR GUIDE FETP Cancer Curriculum: Principles f Cancer Registries Case
More information1. Changes in number of basophils.
Changes in basphil cunt 123 Basphil respnse t antigen and anti-ige. 1. Changes in number f basphils. Yshir Tanizaki and Ikur Kimura 1) Divisin f Medicine, Misasa Medical Branch, 1) Secnd Department f Medicine,
More informationPart 3. Dienoic Fatty Acids
MASS SPECTRA OF 3-PYRIDYLCARBIOL ESTERS Part 3. Dienic Fatty Acids This sectin describes mass spectra f 3-pyridylcarbinl ester derivatives under the headings Methylene-interrupted dienic fatty acids Cnjugated
More informationRuminal Availability of Phosphorus and Its Effect on Digestion
Table 2. Trial results Cncentratin f Captan,ppm liem 0 160 320 640 Dry matter digestibility (%) Ruminal 65.1 72.8 69.4 74.3 Ttal 82.1 81.9 82.4 82.0 Starch digestin (%) Ruminal 87.7 93.6 89.3 92.2 N digestibility
More informationCoding. Training Guide
Cding (Specialty Hspital) Visin 4.3 (January 2013) Training Guide SurceMedical VisinSH Cding Learning Center f Excellence Last change made: January 2013 2013 Surce Medical Slutins, Inc. All Rights Reserved.
More informationIntravenous Vancomycin Use in Adults Intermittent (Pulsed) Infusion
Intravenus Vancmycin Use in Adults Intermittent (Pulsed) Infusin Backgrund This plicy cvers the use f intravenus vancmycin prescribed as an intermittent (pulsed) infusin. This can be used fr treatment
More informationHyperglycaemia: Management of Preterm Infants in Neonatal Intensive Care
1. Purpse Hyperglycaemia in preterm infants is likely due t a number f factrs (impaired insulin secretin, insulin resistance and immaturity f glucse hmestasis regulatin) 1,2. Hyperglycaemia has been assciated
More informationPROTOCOL. SOD2 Protein Quantity Microplate Assay Kit. MS746 Rev.0 DESCRIPTION INTRODUCTION
PROTOCOL SOD2 Prtein Quantity Micrplate Assay Kit 1850 Millrace Drive, Suite 3A Eugene, Oregn 97403 MS746 Rev.0 DESCRIPTION SOD2 Prtein Quantity Micrplate Assay Kit Sufficient materials are prvided fr
More informationPackage leaflet: Information for the user. Fragmin Graduated Syringe 10,000 IU/ml Solution for Injection dalteparin sodium
Package leaflet: Infrmatin fr the user Fragmin Graduated Syringe 10,000 IU/ml Slutin fr Injectin dalteparin sdium Read all f this leaflet carefully befre yu start using this medicine because it cntains
More informationFUNCTIONAL MOVEMENT SYSTEMS SCREEN FINDINGS REPORT
FUNCTIONA MOVEMENT SYSTEMS SCEEN FINDINGS EPOT Screening Date: Client: FMS Certified Member: FMS Scre: 09/0/1 04:15 PM Glenn D'Avanz Elizabeth Carus 17 Descriptin: FMS screen fr Glenn D'Avanz FUNCTIONA
More informationPART III: CONSUMER INFORMATION
IMPORTANT: PLEASE READ PART III: CONSUMER INFORMATION Pr ZERIT Stavudine This leaflet is Part III f a three-part Prduct Mngaph published when ZERIT was apprved fr sale in Canada and is designed specifically
More information