Clinical & Research Studies

Size: px
Start display at page:

Download "Clinical & Research Studies"

Transcription

1 TM Clinicl & Reserch Studies Restores Prevents Protects Relieves Look forwrd to life-long nturlly helthy joints

2 TM

3 4CYTE is Vet Only product. This informtion is intended for the Veterinry Professionl only. independent reserch fcilities to gin insight into the mode of ction of 4CYTE. The summries nd conclusions sited re those of reserchers, mny of which hve een peer reviewed nd pulished. They should not e misconstrued s clims mde y Interpth. Ultimtely the Veterinrin needs to ssess the merits of 4CYTE for use in-clinic. Plese contct Interpth with ny questions nd or for futher informtion on ny of the ppers presented in this document. Phone: Emil: dmin@interpth.net.u TM

4 Pper Reference A rndomised controlled msked clinicl tril of novel nutrceuticl for tretment of Pge 2 osteorthritis in the dog. Melourne University, Fculty of Veterinry Science (212) Ssh s EQ reduces synovil fluid PGE 2 in horses with osteorthritis: clinicl study Pge 3 Wendy Person, Nthlie Cote, Pu Peding EVJ Low qulity of evidence for glucosmine-sed nutrceuticls in equine joint disese - Review of Pge 4 in-vivo studies. W. Person, M. Lindinger. Equine Veterinry Journl (29)41(1)- Evlution of inflmmtory responses induced vi intr-rticulr injection of interleukin-1 Pge 5 in horses receiving dietry nutrceuticl nd ssessment of the clinicl effects of long-term nutrceuticl dministrtion. Wendy Person, Michel W. Orth; Michel I. Lindinger: AMJVR, Vol.7, No.7,(29) Effects of simulted digests of Biot orientlis nd dietry nutrceuticl on interleukin-1 Pge 6 induced inflmmtory responses in crtilge explnts Wendy Person, Michel W. Orth; PhD; Niel A. Krrow, Michel I. Lindinger, AJVR, Vol 69, No.12, Decemer (28 ) Anti-inflmmtory nd chondroprotective effects of nutrceuticls from Ssh s Blend Pge 7 in crtilge explnt model of inflmmtion Wendy Person, Michel W. Orth, et.l, Mol. Nutr. Food Res. (27), 51, *Note Ssh s EQ is the originl term for 4CYTE Equine TM Pge 1

5 % of cses % of cses % of cses % of cses CANINE IN-VIVO STUDY A RANDOMISED CONTROLLED MASKED CLINICAL TRIAL OF A NOVEL NUTRACEUTICAL FOR TREATMENT OF OSTEOARTHRITIS IN THE DOG. L Richrds, J. Alexnder, C. Knight, D. Tyrell, T. Whittem. University of Melourne Fculty of Veterinry Science, Weriee, Victori, Austrli. Presented t: Americn College of Veterinry Internl Medicine (ACVIM) Settle, June 213 Ojective: The ojective of this study ws to compre the efficcy of 4CYTE with positive control NSAID crprofen, for the tretment of nturlly occurring osteorthritis in the dog. The primry hypotheses ws tht improvement in lmeness scores were not different etween tretments. Summry: A rndomised controlled clinicl tril ws used to ssess response to therpy. 82 dogs with clinicl signs of osteorthritis were enrolled in the study of which 16/82 (19.5%) were then excluded due to lck of rdiogrphic evidence of osteorthritis. The remining 66 dogs completed the study. The min reeds represented were cross reeds 2/82 (24%), Lrdors, Retrievers nd Border Collies s the three min pure red cses 22/82 (27%) nd the remining dogs were vriety of pure reeds. All dogs were over 6 months of ge, from 1 to 5 kg nd were enrolled from My 211 to My 212 in Victori, Austrli. The primry outcome ws defined s the inomil improvement versus no improvement of Owner Lmeness Score (OLS) t Dy 28 compred to Dy. Other outcomes were the improvement in OLS, Veterinry Lmeness Score (VLS) nd the Owner Moility Scores (OMS) t Dys 14 nd 28. All outcomes used ordinl oservtion scles with msked ssessment. Outcomes were evluted for non-inferiority using the 9%CI of the difference etween two independent proportions. The Hodges-Lehmnn estimte of the medin of the pirwise differences ws lso clculted from the ordinl rtings CYTE Crprofen 4CYTE Crprofen 14 dys 28 dys 5 Fig 6 - At dy 28 twice the proportion 41.4% of dogs on 4CYTE Cnine improved compred to 21.6% tht received the control. 14 dys 28 dys Fig 6 - At dy 28 twice the proportion 41.4% of dogs on 4CYTE Cnine 64% improved compred to 21.6% tht received the control. 62% 6% 64% 58% 62% 56% TM 4CYTE Crprofen 6% 54% 58% 52% 4CYTE 56% 5% Crprofen 54% -28 dys -28 dys 52% Fig 7 - Between dy nd dy 28 t ny given time point, 62.1% of dogs tht received 4CYTE Cnine improved compred to -28 dys -28 dys 54.1% on the control. 5% Fig 7 - Between dy nd dy 28 t ny given time point, 62.1% of dogs tht received 4CYTE Cnine improved compred to 54.1% on the control. Key Findings: dogs dosed with 4CYTE versus crprofen, OLS t dy 14 improved for 1/29 (34%) dogs nd 13/37 (35%) dogs, nd t Key dy Findings: 28 hd improved for 14/29 (48%) nd 13/37 (35%) For respetively. dogs dosed with 4CYTE versus crprofen, OLS t dy s 14 improved for found 1/29 to (34%) e non-inferior dogs nd 13/37 to crprofen (35%) dogs, t dy 14 for nd t dy 28 hd improved for 14/29 (48%) nd 13/37 (35%) the OMS, nd non-inferior t dy 28 for ll three outcomes. respetively. 4CYTE s ws found support to the e conclusion non-inferior tht to crprofen 4CYTE ws t dy t 14 lest for s the effective OMS, nd s crprofen non-inferior relief t dy of 28 pin for nd ll three lmeness outcomes. resulting from osteorthritis in dult dogs, i.e. clinicl end-point ioequivlence The results support the conclusion tht 4CYTE ws t lest s ws demonstrted. effective s crprofen in relief of pin nd lmeness resulting from osteorthritis in dult dogs, i.e. clinicl end-point ioequivlence ws demonstrted. Pge 2

6 EQUINE CLINICAL TRIAL A DIETARY NUTRACEUTICAL PRODUCT REDUCES SYNOVIAL FLUID PROSTAGLANDIN E2 IN HORSES WITH OSTEOARTHRISTIS: A DOUBLE-BLIND, RANDOMIZED TRIAL. Wendy Person, Nthlie Cote, nd Mrc Desjrdins, (Puliction Pending) Presented t: 213 Americn Assocition of Equine Prctitioners Convention, Anheim. Ojective: The inclusion of DN (composed of New Zelnd green lipped mussel (NZGLM), lone (AB), mrine crtilge (MC) nd proprietry lipid extrct of Biot orientlis (Epiitlis ) in the diet of horses immeditely following surgicl removl of osteochondrl frgment would reduce synovil fluid prostglndin E2 (PGE 2 ), nitric oxide (NO) nd glycosminoglycn (GAG), while improving clinicl signs of rticulr inflmmtion in these horses. Summry: A dietry nutrceuticl product (DN) hs previously demonstrted prophylctic PGE 2 -inhiitory effects in interleukin-1 stimulted crtilge explnts nd in horses with experimentlly-induced rticulr inflmmtion. The current study ws undertken in order to evlute the therpeutic effect of including DN in the diet of horses with rticulr inflmmtion nd/or crtilge dmge secondry to osteochondrl frgmenttion of the crpl or metcrpl joints. Fifteen horses presenting t n equine hospitl for surgicl removl of n osteochondrl frgment of the crpl or metcrpl joints were included. Horses received DN ( or 21 g/dy) for 42 dys eginning immeditely fter surgery. Synovil fluid pre nd post supplementtion ws nlyzed for PGE 2, GAG, nd NO. Rdiogrphs nd lmeness ssessments were lso otined. Synovil Fluid PGE 2 (pg/ml) Before surgery After surgery Fig 5 - Synovil fluid PGE 2 (pg/ml) in Control (n=6) nd 4CYTE /SEQ (DN; n=9) horses. Horses underwent surgicl removl of n osteochondrl frgment on Dy nd received their llocted dietry supplement for 42 dys following surgery. * denotes significnt chnge from seline. Control SEQ Key Findings: Synovil fluid PGE 2 ws significntly reduced from seline in horses receiving DN, ut not in those horses treted with surgery lone. Dt supports previously pulished experimentl evidence of n inhiitory effect of DN on synovil fluid PGE 2. DN my e useful post-surgicl tretment for elevted PGE 2 in horses with surgicl removl of osteochondrl frgments. Pge 3

7 REVIEW OF IN-VIVO STUDIES (Supporting Equine Pper) LOW QUALITY OF EVIDENCE FOR GLUCOSAMINE-BASED NUTRACEUTICALS IN EQUINE JOINT DISEASE: REVIEW OF IN VIVO STUDIES. W. Person, M Lindinger; Equine Veterinry Journl (29) 41(1)- Summry: Nutrceuticls re incresingly pplied to the mngement of equine rthritis nd joint disese, prticulrly those sed upon glucosmine in horses ppered more thn 25 yers go, it ws not until 1992 tht isolte studies egn to e reported. Since tht time,15 in-vivo ppers hve een pulished in the equine literture, usully on products lredy commercilly ville nd often seeking evidence for efficcy. These studies demonstrte n encourging trend to mnufcturers of these products investing in reserch, ut most do not meet qulity stndrd tht provides sufficient confidence in the results reported. This review discusses the entirety of pulished in-vivo reserch on glucosmine-sed nutrceuticls (GBN) for horses, including Cosequin, Cortflex, Synequin, Ssh s EQ (4CYTE Equine), Myristol, chondroitin sulphte, glucosmine sulphte nd glucosmine hydrochloride; nd considers experimentl limittions of this reserch long with their impct on interprettion of results. A qulity score ws clculted for ech pper ccording to preset qulity criteri. A minimum qulity stndrd of 6% ws set s the threshold for confidence in interprettion of results. Of the 15 ppers reviewed, only 3 met the minimum qulity stndrd. Key Findings: It is concluded tht the qulity of studies in this re is generlly low, prohiiting meningful interprettion of the reported results. 4CYTE Equine (Ssh s Equine) hs otined the highest score (68% - see tle 3 Supp1) ccording to these predetermined criteri. In prticulr, the strength of the 4CYTE Equine reserch is tht: Control horses fed plceo diet were included in oth studies (sfety study nd induced inflmmtion study). A sfety study ws done for 84 dys t 7 times the mintennce dose. Synovil (joint) fluid ws ssessed fter 14 dys of 4CYTE Equine supplementtion. Intr-rticulr inflmmtion ws induced nd the effect of 4CYTE Equine fed horses ws mesured compred to plceo fed horses. The importnt thing to relise here is tht the reserch done on 4CYTE Equine focused on ojective outcome mesures (lood tests, urine tests, evlution of GAGs nd enzymes in synovil fluid, joint circumference etc.), rther thn the sujective ssessment (lmeness, flexion tests etc.) of n evlutor. Pge 4

8 EQUINE IN-VIVO & CLINICAL SAFETY (29) EVALUATION OF INFLAMMATORY RESPONSES INDUCED VIA INTRA-ARTICULAR INJECTION OF INTERLEUKIN-1 IN HORSES RECEIVING A DIETARY NUTRACEUTICAL AND ASSESSMENT OF THE CLINICAL EFFECTS OF LONG-TERM NUTRACEUTICAL ADMINISTRATION. Wendy Person; Michel W. Orth; Michel I. Lindinger: Americn Journl of Veterinry Reserch, Vol.7, No.7, (29) Ojective: To evlute inflmmtory responses induced vi intr-rticulr recominnt humn interleukin-1 (IL-1) tretment in horses receiving dietry nutrceuticl (DN; composed of mussel, mrine crtilge, lone nd Epiitlis ) nd ssess the clinicl effects of long-term DN dministrtion. Summry: In previous in-vitro study involving the DN, simulted digest of the product significntly inhiited the inflmmtory response of equine crtilge explnts to exogenous IL-1. To correlte those in-vitro dt with in-vivo dt, IL-1 ws injected into inter-crpl joints of horses to simulte n inflmmtory chllenge in the present study (of 22 helthy horses). 12 horses were fed, 15, 45 or 75mg of DN (3 horses/tretment) dily for 84 dys. Generl helth nd clinic pthologic vriles were monitored t intervls. Ten other horses received or 15mg of DN/d (5 horses/tretment) for 29 dys. One inter-crpl joint in ech horse ws injected twice with IL-1, (1 nd 1ng on dys nd 1, respectively) nd the contrlterl joint ws similrly injected with sline solution. Synovil fluid prostglndin E2, (PGE 2 ) sulfted glycosminoglycn (GAG), nitric oxide (NO), protein concentrtes nd leukocyte counts were nlysed efore nd t intervls fter injections. Synovil fluid PGE 2 pg/ml % Fig 4- Feeding of DN inhiited the increse of PGE 2 (54.6% decrese) nd GAG induced y the intr-rticulr injection of IL-1 highlighting DN nti-inflmmtory nd chondroprotective properties s lso demonstrted in in-vitro studies Control 4CYTE Equine Key Findings: Administrtion of the DN (up to 75g/d) to horses for 84 dys did not induce ny dverse effects. Results suggested tht dministrtion of the DN my e useful in preventing inflmmtion ssocited with rthritis nd degenertive joint disese in horses. Intr-rticulr injection of the IL-1 cused incresed concentrtion of synovil fluid PGE 2 nd GAGs consistent with inflmmtion nd crtilge degrdtion ssocited with rthritis. Feeding of DN inhiited the increse of PGE 2 (54.6% decrese) nd GAG induced y the intr-rticulr injection of IL-1 highlighting DN nti-inflmmtory nd chondroprotective properties s lso demonstrted in in-vitro studies. Feeding DN led to decrese in the circumference of joints swollen y the intr-rticulr dministrtion of IL-1 consistent with inhiition of incresed joint effusion seen in cses of rthritis. Pge 5

9 IN-VITRO STUDY (28) EFFECTS OF SIMULATED DIGESTS OF BIOTA ORIENTALIS AND A DIETARY NUTRACEUTICAL ON INTERLEUKIN-1-INDUCED INFLAMMATORY RESPONSES IN CARTILAGE EXPLANTS. Wendy Person; Michel W.Orth; Niel A. Krrow; Michel I.Lindinger; Americn Journl Veterinry Reserch, Vol 69, No. 12, Decemer (28) Ojective: To test the hypothesis tht simulted digests of Biot orientlis (Epiitlis ) nd dietry nutrceuticl (DN; composed of mussel, mrine crtilge, lone, nd BO seed lipid extrct) inhiit prostglndin E2 (PGE 2 ), nitric oxide (NO), nd glycosminoglycn (GAG) production in interleukin-1 (IL-1) stimulted crtilge explnts. Summry: The University of Guelph conducted series of experiments evluting the effects of Epiitlis on crtilge inflmmtion nd degrdtion induced y interleukin-1 (IL-1). Reserch models pplied in this study were designed to promote in-vitro conditions consistent with the desired context of use of Epiitlis : i.e. tht the product ws to e dministered orlly; the trget tissue ws rticulr crtilge. 2 Prolifertion: equine chondrocytes increse in cell numer (%) Epiitlis Indomethicin Fig 3 - Equine Chondrocyte Prolifertion When chondrocytes were incuted with Epiitlis they produced concentrtion-dependnt increse in prolifertion. Indomethcin however, showed trend towrds inhiiting chondrocyte prolifertion Frction concentrtion (mg/ml) Key Findings: Results of the present study supported the hypotheses tht Epiitlis nd DN modulte response of rticulr crtilge explnts to exogenous IL-1 without dversely ffecting viility or metolism of chondrocytes. The use of indomethcin s reference nti-inflmmtory drug provided n llopthic enchmrk ginst which the effects of these 2 nutrceuticls could e compred. Simulted digests of NZGLM, SC, nd lone (the 3 constituents of the DN other thn Epiitlis ) re known to hve nti-inflmmtory or crtilge-spring effects in IL-1 stimulted crtilge explnts. The dt otined in the present study indicted tht the oil from the seed of BO lso prtilly inhiits IL-1 dependent PGE 2 production y crtilge explnts. The heterogeneous composition of the DN (i.e., NZGLM, SC, lone, nd BO) resulted in significntly improved NO - nd PGE 2 - inhiiting properties, compred with the effects of the individul ingredients lone t the sme dose. This synergistic effect my result from ech ingredient influencing divergent PGE 2 - or NO-synthetic pthwys. In the present study, cell viility susequent to IL-1 chllenge ws significntly incresed y Epiitlis sim nd DN sim. These increses were not result of reduced poptosis, s might hve een predicted from the NO inhiitory properties of the DN, ecuse the increses in viility resulted from n increse in stining of live cells ut not decrese in stining of ded cells. The DN sim, perhps through provision of Epiitlis (which hd lmost equl effect on cell viility), my sim produce n gonist effect on the prostnoid receptor involved in chondrocyte prolifertion, resulting in n increse in live-cell stining. Pge 6

10 IN-VITRO STUDY (27) ANTI-INFLAMMATORY AND CHONDROPROTECTIVE EFFECTS OF NUTRACEUTICALS FROM SASHA S BLEND IN A CARTILAGE EXPLANT MODEL OF INFLAMMATION Wendy Person, Michel W. Orth, et.l, Moleculr Nutrition nd Food Reserch. (27), 51, NOTE: This in-vitro study ws the first reserch pper specificlly looking t the seprte ingredients which mde up Sshs Blend product line. These sme mrine ingredients re lso utilised in 4CYTE nd these results hve influenced nd provide comprison for the 4CYTE reserch progrms. Ojective: The ojective of this study ws to evlute the nti-inflmmtory nd chondroprotective effects of the New Zelnd green lipped mussel (NZGLM), lone (AB), nd mrine crtilge (SC) using crtilge explnt model of inflmmtion. Summry: New Zelnd green lipped mussel (NZGLM), lone (AB), nd mrine crtilge (SC) re extensively used for tretment of nd/or s preventtives for rthritis, despite reltive pucity of scientific evidence for efficcy. This reserch integrted simulted digestion protocol with ultrfiltrtion nd crtilge explnts to generte new informtion on the nti-inflmmtory nd chondroprotective properties of NZGLM, SC nd AB. Ech nutrceuticl ws rtificilly digested using simulted gstric nd intestinl fluids. Ech filtrte ws pplied individully to crtilge explnts efore the explnts were stimulted with interleukin-1 (IL-1) to induce n cute inflmmtory response. Medi were collected dily for 48hrs nd nlyzed for prostglndin E2 (PGE 2 ), glycosminoglycn (GAG) nd nitric oxide (NO), nd crtilge tissue ws differentilly stined to determine the reltive proportion of live nd ded cells h 24h 48h A h Fig 1 A Fig 2 24h 48h 1.4 c Medi [GAG] ug/ml Medi [nitrite] ug/ml c Medi [GAG] ug/ml h 24h 48h B.2. stimulted control SC NZGLM AB Nitric oxide production y IL-1-stimulted explnts conditioned with shrk crtilge (SC), New Zelnd Green Lipped Mussel (NZGLM) or lone (AB) (.6mg/mL). Letters denote significnt IL-1-induced increse in medi [nitrite]. There ws no difference etween control explnts or explnts conditioned with NZGLM or SC. Conditioning with AB resulted in significntly lower medi [nitrite] thn IL-1-stimulted controls.. stimulted control SC NZGLM AB GAG relese from IL-1 (1ng/mL)-stimulted crtilge explnts conditioned with.6mg/ml (Pnel A) or.18mg/ml (Pnel B) ) of shrk crtilge (SC), New Zelnd Green Lipped Mussel (NZGLM) nd lone (AB). IL-1-dependent increses in medi [GAG] were not significnt in explnts conditioned with SC or NZGLM (.6 nd.18mg/ml). Conditioning with NZGLM (.18mg/mL) resulted in medi [GAG] tht ws significntly lower thn stumlted controls. Conditioning with AB (.6 nd.18mg/ml) significntly reduced medi [GAG] fter 48h of IL-1 exposure. Key Findings: SC nd NZGLM significntly inhiited IL-1 induced PGE 2 synthesis nd IL-1 induced GAG relese, nd AB ws n effective inhiitor of IL-1 induced NO production. The three test nutrceuticls ffect t lest three mjor pthwys involved in the ctolic cycle of rthritis nd my prove importnt tretments nd/or preventtives for the pin nd degrdtion ssocited with this condition. The methodology nd results descrie useful model for evluting dietry nutrceuticls in-vitro. Pge 7

11 TM

12 TM Look forwrd to life-long nturlly helthy joints

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 : PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged

More information

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE Swine Dy 22 Contents EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE B. J. Johnson, J. P. Kyser, J. D. Dunn, A. T. Wyln, S. S. Dritz 1, J.

More information

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess

More information

Using Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids

Using Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids Using Pcloutrzol to Suppress Inflorescence Height of Potted Phlenopsis Orchids A REPORT SUBMITTED TO FINE AMERICAS Linsey Newton nd Erik Runkle Deprtment of Horticulture Spring 28 Using Pcloutrzol to Suppress

More information

Input from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer

Input from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer Input externl experts nd mnufcturer on the 2 nd drft project pln Stool DNA testing for erly detection of colorectl cncer (Project ID:OTJA10) All s nd uthor s replies on the 2nd drft project pln Stool DNA

More information

Optimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality

Optimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality Optimistion of diets for Atlntic cod (Gdus morhu) roodstock: effect of rchidonic cid on egg & lrvl qulity Dr Gordon Bell, Ms. An Blnco, Dr Bill Roy, Dr Derek Roertson, Dr Jim Henderson nd Mr Richrd Prickett,

More information

SYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT

SYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT Finl Arevited Clinicl Study Report Nme of Sponsor/Compny: Bristol-Myers Squi Ipilimum Individul Study Tle Referring to the Dossier (For Ntionl Authority Use Only) Nme of Finished Product: Yervoy Nme of

More information

Meat and Food Safety. B.A. Crow, M.E. Dikeman, L.C. Hollis, R.A. Phebus, A.N. Ray, T.A. Houser, and J.P. Grobbel

Meat and Food Safety. B.A. Crow, M.E. Dikeman, L.C. Hollis, R.A. Phebus, A.N. Ray, T.A. Houser, and J.P. Grobbel Met nd Food Sfety Needle-Free Injection Enhncement of Beef Strip Loins with Phosphte nd Slt Hs Potentil to Improve Yield, Tenderness, nd Juiciness ut Hrm Texture nd Flvor B.A. Crow, M.E. Dikemn, L.C. Hollis,

More information

THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS

THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS John F. Ptience nd Doug Gillis SUMMARY

More information

Bioactive milk components to secure growth and gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM

Bioactive milk components to secure growth and gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM Bioctive milk components to secure growth nd gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM STSM Pigutnet FA1401 STSM 03/Septemer 30/Novemer/2017 (3 months) Host: Home: Thoms

More information

Surgical stress influences cytokine content in autologous conditioned serum

Surgical stress influences cytokine content in autologous conditioned serum s_s_nner Surgicl stress influences cytokine content in utologous conditioned serum C. T. FJORDBAKK*, G. M. JOHANSEN, A. C. LØVÅS, K. L. OPPEGÅRD nd A. K. STORSET Deprtment of Compnion Animl Clinicl Sciences,

More information

Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults Executive Summary

Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults Executive Summary Comprtive Effectiveness Review Numer 33 Effective Helth Cre Progrm Nonphrmcologic Interventions for Tretment-Resistnt Depression in Adults Executive Summry Bckground Mjor depressive disorder (MDD) is common

More information

WSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265;

WSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265; FINAL REPORT WTFRC Project # AH-1-5 WSU Project # 13C-355-3 Project title: PI: Orgniztion: Coopertors: of Sunburn in Apples with RAYNOX Lrry Schrder, Horticulturist WSU Tree Fruit Reserch nd Extension

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION Prentl doi:.8/nture57 Figure S HPMECs LM Cells Cell lines VEGF (ng/ml) Prentl 7. +/-. LM 7. +/-.99 LM 7. +/-.99 Fold COX induction 5 VEGF: - + + + Bevcizum: - - 5 (µg/ml) Reltive MMP LM mock COX MMP LM+

More information

Bright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit

Bright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit Bright Futures Medicl Reference Tle 2 to 5 Dy (First Week) Visit Universl Action Metolic nd Verify documenttion of neworn metolic screening results, pproprite rescreening, nd needed follow-up. Document

More information

PROVEN ANTICOCCIDIAL IN NEW FORMULATION

PROVEN ANTICOCCIDIAL IN NEW FORMULATION PROVEN ANTICOCCIDIAL IN NEW FORMULATION Coxidin 100 microgrnulte A coccidiosttic dditive for roilers, chickens rered for lying nd turkeys Contins 100 g of monensin sodium per kg Aville s homogenous grnules

More information

Abstract ABSTRACT #69. Abstract. Introduction & Methods. Methods & Results. Results. Results & Conclusions

Abstract ABSTRACT #69. Abstract. Introduction & Methods. Methods & Results. Results. Results & Conclusions Effects of dietry β-glucn on Growth Performnce, Dirrhe, nd Gut Permeility of Wening Pigs Experimentlly Infected with Pthogenic E. coli Kwngwook Kim, Amy Ehrlich, Vivin Perng, Jennifer Chse, Helen Ryould,

More information

Invasive Pneumococcal Disease Quarterly Report July September 2018

Invasive Pneumococcal Disease Quarterly Report July September 2018 Invsive Pneumococcl Disese Qurterly Report July Septemer Introduction Since 17 Octoer 2008, invsive pneumococcl disese (IPD) hs een notifile to the locl Medicl Officer of Helth under the Helth Act 1956.

More information

Osteoarthritis, also known as degenerative joint

Osteoarthritis, also known as degenerative joint This rticle is protected by copyright. To shre or copy this rticle, plese visit copyright.com. Use ISSN#1543953X. To subscribe, visit imjournl.com ORIGINAL RESEARCH An Osteoinductive Protein Complex Tht

More information

XII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV

XII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV XII. HIV/AIDS Knowledge bout HIV Trnsmission nd Misconceptions bout HIV One of the most importnt prerequisites for reducing the rte of HIV infection is ccurte knowledge of how HIV is trnsmitted nd strtegies

More information

Adenosine A1 receptor antagonist improves intradialytic hypotension

Adenosine A1 receptor antagonist improves intradialytic hypotension http://www.kidney-interntionl.org & 26 Interntionl Society of Nephrology originl rticle see commentry on pge 789 Adenosine A1 receptor ntgonist improves intrdilytic hypotension E Imi 1, M Fujii 2, Y Kohno

More information

DR. MARC PAGÈS Project Manager R&D Biologicals - Coccidia Projects, HIPRA

DR. MARC PAGÈS Project Manager R&D Biologicals - Coccidia Projects, HIPRA DR. MARC PAGÈS Project Mnger R&D Biologicls - Coccidi Projects, HIPRA Dr. Mrc Pgès Bosch otined Microiology nd Genetics degree t the University of Brcelon in 1998. He otined his PhD working on the synptoneml

More information

Agilent G6825AA MassHunter Pathways to PCDL Software Quick Start Guide

Agilent G6825AA MassHunter Pathways to PCDL Software Quick Start Guide Agilent G6825AA MssHunter Pthwys to PCDL Softwre Quick Strt Guide Wht is Agilent Pthwys to PCDL? Fetures of Pthwys to PCDL Agilent MssHunter Pthwys to PCDL converter is stnd-lone softwre designed to fcilitte

More information

LATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1

LATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1 LATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1 W. G. J. HAMPSON nd P. HILL, BRISTOL, ENGLAND The uthors wished to determine the lte results of the Huser opertion,

More information

Supplementary figure 1

Supplementary figure 1 Supplementry figure 1 Dy 8 post LCMV infection Vsculr Assoc. Prenchym Dy 3 post LCMV infection 1 5 6.7.29 1 4 1 3 1 2 88.9 4.16 1 2 1 3 1 4 1 5 1 5 1.59 5.97 1 4 1 3 1 2 21.4 71 1 2 1 3 1 4 1 5 1 5.59.22

More information

METHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY

METHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY METHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY 1.0 SCOPE AND APPLICATION 1.1 Method 4010 is procedure for screening solids such s soils, sludges, nd queous medi such s wste wter nd lechtes

More information

Goal: Evaluate plant health effects while suppressing dollar spot and brown patch

Goal: Evaluate plant health effects while suppressing dollar spot and brown patch Newer Fungicide Products Alone nd In Rottion on Chicgo Golf Green Reserchers: Chicgo District Golf Assoc. Derek Settle, Tim Sibicky, nd Nick DeVries Gol: Evlute plnt helth effects while suppressing dollr

More information

EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE

EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE Swine Dy 21 EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE J. M. DeRouchey, M. D. Tokch, J. L. Nelssen, R. D. Goodbnd, S. S. Dritz 1, J. C. Woodworth, M. J. Webster, B. W.

More information

Consumer perceptions of meat quality and shelf-life in commercially raised broilers compared to organic free range broilers

Consumer perceptions of meat quality and shelf-life in commercially raised broilers compared to organic free range broilers Consumer perceptions of met qulity nd shelf-life in commercilly rised roilers compred to orgnic free rnge roilers C.Z. ALVARADO 1 *, E. WENGER 2 nd S. F. O KEEFE 3 1 Texs Tech University, Box 42141 Luock,

More information

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei

More information

Study of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method

Study of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method Ksetsrt J. (Nt. Sci.) 48 : 729-739 (2014) Study of Stress Distriution in the Tii During Stnce Phse Running Using the Finite Element Method Thepwchr Ruchirh 1, Tumrong Puttpitukporn 1, * nd Siriporn Ssimontonkul

More information

The Effect of Substituting Sugar with Artificial. Sweeteners on the Texture and Palatability of Pancakes

The Effect of Substituting Sugar with Artificial. Sweeteners on the Texture and Palatability of Pancakes The Effect of Sustituting Sugr with Artificil NUTR 453 Sweeteners on the Texture nd Pltility of Pnckes Jmie Wldron, Rquel Reyes, nd Reecc Legi 1 I. Astrct The effects of replcing sugr with Stevi nd Splend

More information

EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1

EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 Swine Dy 2001 Contents EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 C. W. Hstd, S. S. Dritz 2, J. L. Nelssen, M. D. Tokch, nd R. D. Goodbnd Summry Two trils were

More information

Safety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA

Safety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA Sfety nd Tolerbility of Subcutneous Srilumb nd Intrvenous Tocilizumb in Ptients With RA Pul Emery, 1 Jun Rondon, 2 Anju Grg, 3 Hubert vn Hoogstrten, 3 Neil M.H. Grhm, 4 Ming Liu, 4 Nncy Liu, 3 Jnie Prrino,

More information

Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression

Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression Online Sumissions:http://www.journltcm.com J Trdit Chin Med 2013 Octoer 15; 33(5): 674-681 info@journltcm.com ISSN 0255-2922 2013 JTCM. All rights reserved. EXPERIMENTAL STUDY TOPIC Effects of Sini Sn

More information

Addendum to the Evidence Review Group Report on Aripiprazole for the treatment of schizophrenia in adolescents (aged years)

Addendum to the Evidence Review Group Report on Aripiprazole for the treatment of schizophrenia in adolescents (aged years) Addendum to the Evidence Review Group Report on Aripiprzole for the tretment of schizophreni in dolescents (ged 15-17 yers) Produced by Authors Correspondence to Southmpton Helth Technology Assessments

More information

Metabolic syndrome as a risk factor for high-ocular tension

Metabolic syndrome as a risk factor for high-ocular tension Interntionl Journl of Oesity (2010) 1 9 & 2010 Mcmilln Pulishers Limited All rights reserved 0307-0565/10 $32.00 www.nture.com/ijo ORIGINAL ARTICLE Metolic syndrome s risk fctor for high-oculr K Imi 1,

More information

Effect of Aqueous Extract of Carica papaya Dry Root Powder on Lactation of Albino Rats

Effect of Aqueous Extract of Carica papaya Dry Root Powder on Lactation of Albino Rats Effect of Aqueous Extrct of Cric ppy Dry Root Powder on Lcttion of Alino Rts G. Tosswnchuntr nd S. Aritjt Deprtment of Biology Fculty of Science Ching Mi University Ching Mi 50200 Thilnd Keywords: mmmry

More information

Debra A. Ignaut, R.N., B.S., C.D.E., and Haoda Fu, Ph.D.

Debra A. Ignaut, R.N., B.S., C.D.E., and Haoda Fu, Ph.D. Journl of Dietes Science nd Technology Volume 6, Issue 2, Mrch 2012 Dietes Technology Society TECHNOLOGY REPORT Comprison of Insulin Diluent Lekge Postinjection Using Two Different Needle Lengths nd Injection

More information

11/7/2011. Disclosures. Psoriatic Arthritis (PsA) DC-STAMP I II III IV. None

11/7/2011. Disclosures. Psoriatic Arthritis (PsA) DC-STAMP I II III IV. None unstimulte stimulte 11/7/11 Ientifiction of Unique Suset + (Denritic Cell-Specific Trnsmemrne Protein) T cells with Th17 Signture in Psoritic rthritis () Ptients Disclosures None Y.H. Chiu, E.M. Schwrz,

More information

Optimizing Metam Sodium Fumigation in Fine-Textured Soils

Optimizing Metam Sodium Fumigation in Fine-Textured Soils Optimizing Metm Sodium Fumigtion in Fine-Textured Soils Neil C Gudmestd University Distinguished Professor & Endowed Chir of Potto Pthology Deprtment of Plnt Pthology North Dkot Stte University Erly Dying

More information

With. The NEW vaccine against Swine Erysipelas and Porcine Parvovirus infection. A powerful immunity you can rely on

With. The NEW vaccine against Swine Erysipelas and Porcine Parvovirus infection. A powerful immunity you can rely on With The NEW vccine ginst Swine Erysipels nd Porcine Prvovirus infection A powerful immunity you cn rely on Swine Erysipels Erysipelothrix rhusiopthie cn e found on most pig frms: it cuses Swine Erysipels,

More information

Effect of vitamin D on the recurrence rate of rheumatoid arthritis

Effect of vitamin D on the recurrence rate of rheumatoid arthritis 1812 Effect of vitmin D on the recurrence rte of rheumtoid rthritis JUNXIA YANG 1, LIN LIU 1, QINGLIN ZHANG 2, MEIRONG LI 1 nd JINGYA WANG 1 1 Deprtment of Rheumtology, 2 Centrl Lbortory, Xuzhou Centrl

More information

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn

More information

The effect of encapsulated butyric acid and zinc on performance, gut integrity and meat quality in male broiler chickens 1

The effect of encapsulated butyric acid and zinc on performance, gut integrity and meat quality in male broiler chickens 1 The effect of encpsulted utyric cid nd zinc on performnce, gut integrity nd met qulity in mle roiler chickens 1 Astrct This study evluted the impct of encpsulted utyric cid nd zinc (ButiPEARL Z) on performnce

More information

Reducing the Risk. Logic Model

Reducing the Risk. Logic Model Reducing the Risk Logic Model ETR (Eduction, Trining nd Reserch) is nonprofit orgniztion committed to providing science-bsed innovtive solutions in helth nd eduction designed to chieve trnsformtive chnge

More information

Effect of supplemental fat from dried distillers grains with solubles or corn oil on cow performance, IGF-1, GH, and NEFA concentrations 1

Effect of supplemental fat from dried distillers grains with solubles or corn oil on cow performance, IGF-1, GH, and NEFA concentrations 1 Effect of supplementl ft from dried distillers grins with solules or corn oil on cow performnce, IGF-1, GH, nd NEFA concentrtions 1 Aigil Brtosh 2, Cody Wright 3, Aimee Wertz-Lutz 4, nd George Perry 5

More information

The RUTHERFORD-2 trial in heterozygous FH: Results and implications

The RUTHERFORD-2 trial in heterozygous FH: Results and implications The RUTHERFORD-2 tril in heterozygous FH: Results nd implictions Slide deck kindly supplied s n eductionl resource by Professor Derick Rl MD PhD Crbohydrte & Lipid Metbolism Reserch Unit University of

More information

Pilot Trial of Osteopathic Manipulative Therapy for Patients With Frequent Episodic Tension-Type Headache

Pilot Trial of Osteopathic Manipulative Therapy for Patients With Frequent Episodic Tension-Type Headache Pilot Tril of Osteopthic Mnipultive Therpy for Ptients With Frequent Episodic Tension-Type Hedche Guido Rolle, MD, DO (Itly); Lucio Tremolizzo, MD, PhD; Frncesco Somlvico, MS; Crlo Ferrrese, MD, PhD; nd

More information

Assessment of Depression in Multiple Sclerosis. Validity of Including Somatic Items on the Beck Depression Inventory II

Assessment of Depression in Multiple Sclerosis. Validity of Including Somatic Items on the Beck Depression Inventory II Assessment of Depression in Multiple Sclerosis Vlidity of Including Somtic Items on the Beck Depression Inventory II Peggy Crwford, PhD; Noh J. Webster, MA Signs nd symptoms of multiple sclerosis (MS)

More information

INFLUENCE OF DIFFERENT STRAINS AND WAYS OF INOCULATION ON THE RABBIT S RESPONSE TO EXPERIMENTAL INFECTION WITH PASTEURELLA MULTOCIDA

INFLUENCE OF DIFFERENT STRAINS AND WAYS OF INOCULATION ON THE RABBIT S RESPONSE TO EXPERIMENTAL INFECTION WITH PASTEURELLA MULTOCIDA Pthology nd Hygiene INFLUENCE OF DIFFERENT STRAINS AND WAYS OF INOCULATION ON THE RABBIT S RESPONSE TO EXPERIMENTAL INFECTION WITH PASTEURELLA MULTOCIDA Kulcsár G. 1, Fáián K. 1 *, Brn T. 1, Virág Gy.

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION SUPPLEMENTARY INFORMATION doi:10.1038/nture11225 Numer of OTUs sed on 3% distnce Numer of 16s rrna-sed V2-V4 tg sequences LF MF PUFA Supplementry Figure 1. High-ft diets decrese the richness nd diversity

More information

Invasive Pneumococcal Disease Quarterly Report. July September 2017

Invasive Pneumococcal Disease Quarterly Report. July September 2017 Invsive Pneumococcl Disese Qurterly Report July September 2017 Prepred s prt of Ministry of Helth contrct for scientific services by Rebekh Roos Helen Heffernn October 2017 Acknowledgements This report

More information

The Acute Time Course of Concurrent Activation Potentiation

The Acute Time Course of Concurrent Activation Potentiation Mrquette University e-publictions@mrquette Exercise Science Fculty Reserch nd Publictions Exercise Science, Deprtment of 1-1-2010 The Acute Time Course of Concurrent Activtion Potentition Luke Grceu Mrquette

More information

Hallux valgus and cartilage degeneration in the first metatarsophalangeal joint

Hallux valgus and cartilage degeneration in the first metatarsophalangeal joint Hllux vlgus nd crtilge degenertion in the first mettrsophlngel joint P. Bock, K.-H. Kristen, A. Kröner, A. Engel From the Dnue Hospitl, Vienn, Austri This study reltes the extent of crtilge lesions within

More information

Effect of fungicide timing and wheat varietal resistance on Mycosphaerella graminicola and its sterol 14 α-demethylation-inhibitorresistant

Effect of fungicide timing and wheat varietal resistance on Mycosphaerella graminicola and its sterol 14 α-demethylation-inhibitorresistant Effect of fungicide timing nd whet vrietl resistnce on Mycospherell grminicol nd its sterol 14 α-demethyltion-inhiitorresistnt genotypes Didierlurent L., Roisin-Fichter C., Snssené J., Selim S. Pltform

More information

Soybean Hulls as an Alternative Feed for Horses

Soybean Hulls as an Alternative Feed for Horses Animl Industry Report AS 650 ASL R1931 2004 Soyben Hulls s n Alterntive Feed for Horses Josie Booth Iow Stte University Howrd Tyler Iow Stte University Peggy Miller-Auwerd Iow Stte University Jenette Moore

More information

Feeding state and age dependent changes in melaninconcentrating hormone expression in the hypothalamus of broiler chickens

Feeding state and age dependent changes in melaninconcentrating hormone expression in the hypothalamus of broiler chickens Supplementry Mterils Epub: No 2017_23 Vol. 65, 2018 https://doi.org/10.183/bp.2017_23 Regulr pper Feeding stte nd ge dependent chnges in melninconcentrting hormone expression in the hypothlmus of broiler

More information

Therapeutic Effects of Short-term Supplementation of 0.5 and 1.0% Pineapple Shell on Rabbits with Experimentally Induced Osteoarthritis

Therapeutic Effects of Short-term Supplementation of 0.5 and 1.0% Pineapple Shell on Rabbits with Experimentally Induced Osteoarthritis 564 Ching Mi J. Sci. 2013; 40(4) Ching Mi J. Sci. 2013; 40(4) : 564-576 http://it.science.cmu.c.th/ejournl/ Contriuted Pper Therpeutic Effects of Short-term Supplementtion of 0.5 nd 1.0% Pinepple Shell

More information

Mecadox. Improves pig performance in a wide range of health and growing conditions. (Carbadox) Talk With a Phibro Expert:

Mecadox. Improves pig performance in a wide range of health and growing conditions. (Carbadox) Talk With a Phibro Expert: SWINE (Crbdox) Improves pig performnce in wide rnge of helth nd growing conditions The Advntge Over the yers, medicted feed dditive hs proven to be cost-effective mngement tool for improving pig performnce

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION DOI: 1.138/nc286 Figure S1 e f Medium DMSO AktVIII PP242 Rp S6K1-I Gr1 + + + + + + Strvtion + + + + + IB: Akt-pT38 IB: Akt K-pT389 K IB: Rptor Gr1 shs6k1-a shs6k1-b shs6k1-c shrictor shrptor Gr1 c IB:

More information

Effect of orthodontic treatment on oral health related quality of life

Effect of orthodontic treatment on oral health related quality of life Originl Article Effect of orthodontic tretment on orl helth relted qulity of life Dniel Feu ; Jose Augusto M. Miguel ; Roger K. Celeste c ; Brnc Helois Oliveir d ABSTRACT Ojective: To ssess chnges in orl

More information

Extraction and Some Functional Properties of Protein Extract from Rice Bran

Extraction and Some Functional Properties of Protein Extract from Rice Bran Ksetsrt J. (Nt. Sci.) 40 : 209-214 (2006) Extrction nd Some Functionl Properties of Protein Extrct from Rice Brn Chockchi Theerkulkit*, Siree Chiseri nd Siriwt Mongkolknchnsiri ABSTRACT Rice brn protein

More information

TNF-α (pg/ml) IL-6 (ng/ml)

TNF-α (pg/ml) IL-6 (ng/ml) Xio, et l., Supplementry Figure 1 IL-6 (ng/ml) TNF-α (pg/ml) 16 12 8 4 1,4 1,2 1, 8 6 4 2 med Cl / Pm3CSK4 zymosn curdln Poly (I:C) LPS flgelin MALP-2 imiquimod R848 CpG TNF-α (pg/ml) IL-6 (ng/ml) 2 1.6

More information

FERTILITY EFFECTS OF SODIUM FLUORIDE IN MALE MICE

FERTILITY EFFECTS OF SODIUM FLUORIDE IN MALE MICE 128 Fluoride Vol. 33 No. 3 128-134 2000 Reserch Report FERTILITY EFFECTS OF SODIUM FLUORIDE IN MALE MICE Ahmed Elbetieh, Hom Drmni, Ahmd S Al-Hiyst b Irbid, Jordn SUMMARY: Sexully mture mle Swiss mice

More information

Research Article Amelioration of Collagen-Induced Arthritis in Female Dark Agouti Rats by Glucosamine Treatment

Research Article Amelioration of Collagen-Induced Arthritis in Female Dark Agouti Rats by Glucosamine Treatment Hindwi Publishing Corportion ISRN Phrmcology Volume 2013, Article ID 562905, 7 pges http://dx.doi.org/10.1155/2013/562905 Reserch Article Ameliortion of Collgen-Induced Arthritis in Femle Drk Agouti Rts

More information

Enhanced Chemopreventive Effect by Combining Quercetin and Green tea in Prostate Cancer

Enhanced Chemopreventive Effect by Combining Quercetin and Green tea in Prostate Cancer Enhnced Chemopreventive Effect y Comining Quercetin nd Green te in Prostte Cncer Piwen Wng, MD, PhD Assistnt Professor, Division of Cncer Reserch nd Trining Chrles R. Drew University of Medicine nd Science

More information

Diabetes affects 29 million Americans, imposing a substantial

Diabetes affects 29 million Americans, imposing a substantial CLINICAL Comprtive Effectiveness nd Costs of Insulin Pump Therpy for Dibetes Ronld T. Ackermnn, MD, MPH; Amish Wlli, MD, MS; Rymond Kng, MA; Andrew Cooper, MPH; Theodore A. Prospect, FSA, MAAA; Lewis G.

More information

Anti-Obesity Potential of Gallic Acid from Labisia pumila, through Augmentation of Adipokines in High Fat Diet Induced Obesity in C57BL/6 Mice

Anti-Obesity Potential of Gallic Acid from Labisia pumila, through Augmentation of Adipokines in High Fat Diet Induced Obesity in C57BL/6 Mice Advnces in Reserch 2(10): 556-570, 2014, Article no. AIR.2014.10.004 SCIENCEDOMAIN interntionl www.sciencedomin.org Anti-Oesity Potentil of Gllic Acid from Lisi pumil, through Augmenttion of Adipokines

More information

Y. Yazici 1, D. Moniz Reed 2, C. Klem 2, L. Rosenblatt 2, G. Wu 2, J.M. Kremer 3

Y. Yazici 1, D. Moniz Reed 2, C. Klem 2, L. Rosenblatt 2, G. Wu 2, J.M. Kremer 3 Greter remission rtes in ptients with erly versus long-stnding disese in biologic-nive rheumtoid rthritis ptients treted with btcept: post hoc nlysis of rndomised clinicl tril dt Y. Yzici 1, D. Moniz Reed

More information

Treatment for Hearing Loss among the Elderly: Auditory Outcomes and Impact on Quality of Life

Treatment for Hearing Loss among the Elderly: Auditory Outcomes and Impact on Quality of Life Audiology Neurotology Proceedings Audiol Neurotol 216;21(suppl 1):29 35 DOI: 1.1159/448352 Pulished online: Novemer 3, 216 Tretment for Hering Loss mong the Elderly: Auditory Outcomes nd Impct on Qulity

More information

Appendix J Environmental Justice Populations

Appendix J Environmental Justice Populations Appendix J Environmentl Justice s [This pge intentionlly left blnk] Tble of Contents REFERENCES...J-2 Pge LIST OF TABLES Pge Tble J-1: Demogrphic Overview of Bruinsburg Site Project Are... J-3 Tble J-2:

More information

Heather M. Kelly Field Crops Plant Pathologist UT-WTREC, Jackson, TN

Heather M. Kelly Field Crops Plant Pathologist UT-WTREC, Jackson, TN Trget Spot: Potentil Impcts on Tennessee Cotton Hether M. Kelly Field Crops Plnt Pthologist UT-WTREC, Jckson, TN Trget Spot/ Corynespor lef spot First ppers on lower leves fter cnopy closure Defolites

More information

Arthroscopic Anatomy of Shoulder

Arthroscopic Anatomy of Shoulder Arthroscopic Antomy of Shoulder Murt Bozkurt, Mehmet Emin Simsek, nd Hlil İrhim Açr 2 2.1 Introduction In the lst 30 yers, shoulder rthroscopy hs ecome of greter importnce in the dignosis nd tretment of

More information

The Ever Changing World of Feed Additives in The Poultry Industry

The Ever Changing World of Feed Additives in The Poultry Industry The Ever Chnging World of Feed Additives in The Poultry Industry B. S. Lumpkins nd G.F. Mthis Southern Poultry Reserch Inc. Athens, GA, USA Outline Southern Poultry Reserch Impct of ethnol production of

More information

Effect of linear and random non-linear programming on environmental pollution caused by broiler production

Effect of linear and random non-linear programming on environmental pollution caused by broiler production Journl of Novel Applied Sciences Aville online t www.jnsci.org 24 JNAS Journl-24-3-/43-434 ISSN 2322-549 24 JNAS Effect of liner nd rndom non-liner progrmming on environmentl pollution cused y roiler production

More information

In the treatment of cardiovascular disease (CVD), national

In the treatment of cardiovascular disease (CVD), national n report n Beyond LDL Cholesterol: The Role of Elevted Triglycerides nd Low HDL Cholesterol in Residul CVD Risk Remining After Sttin Therpy Peter Algon Jr, MD, FACC In the tretment of crdiovsculr disese

More information

Dr. Javier Polo Vice President Research & Development

Dr. Javier Polo Vice President Research & Development Efecto de l suplementción con concentrdo de inmunoglobulins prtir del suero bovino en l Microbiot y su contribución l slud intestinl y l sistem nervioso centrl Dr. Jvier Polo Vice President Reserch & Development

More information

US Food and Drug Administration-Mandated Trials of Long-Acting b -Agonists Safety in Asthma. Samy Suissa, PhD ; and Amnon Ariel, MD, FCCP

US Food and Drug Administration-Mandated Trials of Long-Acting b -Agonists Safety in Asthma. Samy Suissa, PhD ; and Amnon Ariel, MD, FCCP CHEST Commentry US Food nd Drug Administrtion-Mndted Trils of Long-Acting b -Agonists Sfety in Asthm Will We Know the Answer? Smy Suiss, PhD ; nd Amnon Ariel, MD, FCCP For 2 decdes, long-cting b -gonists

More information

Roughage Type & Level & Grain Processing Interactions with Distiller s s Grains Diets. Matt May High Plains Bio Fuels Co-Product Nutrition Conference

Roughage Type & Level & Grain Processing Interactions with Distiller s s Grains Diets. Matt May High Plains Bio Fuels Co-Product Nutrition Conference Roughge Type & Level & Grin Processing Interctions with Distiller s s Grins Diets Mtt My High Plins Bio Fuels Co-Product Nutrition Conference Why do we flke grin? Stem-flked corn (SFC) vs. dry-rolled rolled

More information

ORIGINAL INVESTIGATION. Exercise and Weight Loss Reduce Blood Pressure in Men and Women With Mild Hypertension

ORIGINAL INVESTIGATION. Exercise and Weight Loss Reduce Blood Pressure in Men and Women With Mild Hypertension ORIGINAL INVESTIGATION Exercise nd Weight Loss Reduce Blood Pressure in Men nd Women With Mild Hypertension Effects on Crdiovsculr, Metolic, nd Hemodynmic Functioning Jmes A. Blumenthl, PhD; Andrew Sherwood,

More information

Abnormalities of total serum magnesium concentration

Abnormalities of total serum magnesium concentration J Vet Intern Med 2002;16:217 221 Prevlence nd Incidence of Serum Mgnesium Anormlities in Hospitlized Cts Jeffrey Toll, Hollis Er, Nichole Birnum, nd Thoms Schermerhorn Totl serum mgnesium concentrtion

More information

Product Monograph. Published by

Product Monograph. Published by Product Monogrph Pulished y INDICATION AND LIMITATION OF USE JARDIANCE is indicted s n djunct to diet nd exercise to improve glycemic control in dults with type 2 dietes mellitus. JARDIANCE is not recommended

More information

EFFECT OF DIETARY ENZYME ON PERFORMANCE OF WEANLING PIGS

EFFECT OF DIETARY ENZYME ON PERFORMANCE OF WEANLING PIGS EFFECT OF DIETARY ENZYME ON PERFORMANCE OF WEANLING PIGS Finl report sumitted to Dniso Animl Nutrition E. vn Heugten nd B. Frederik North Crolin Stte University, Deprtment of Animl Siene Summry The urrent

More information

Impact of Pharmacist Intervention on Diabetes Patients in an Ambulatory Setting

Impact of Pharmacist Intervention on Diabetes Patients in an Ambulatory Setting Impct of Phrmcist Intervention on Dibetes Ptients in n Ambultory Setting Julie Stding, PhrmD, CDE, Jmie Herrmnn, PhrmD, Ryn Wlters, MS, Chris Destche, PhrmD, nd Aln Chock, PhrmD Dibetes is the seventh-leding

More information

Radiographic evaluation of the technical quality of undergraduate endodontic competence cases in the Dublin Dental University Hospital: an audit

Radiographic evaluation of the technical quality of undergraduate endodontic competence cases in the Dublin Dental University Hospital: an audit Rdiogrphic evlution of the technicl qulity of undergrdute endodontic competence cses in the Dulin Dentl University Hospitl: n udit Précis: An udit exmining the technicl qulity of undergrdute endodontic

More information

How Do Emergency Physicians Interpret Prescription Narcotic History When Assessing Patients Presenting to the Emergency Department with Pain?

How Do Emergency Physicians Interpret Prescription Narcotic History When Assessing Patients Presenting to the Emergency Department with Pain? credits ville for this rticle see pge 80. How Do Emergency Physicins Interpret Prescription Nrcotic History When Assessing Ptients Presenting to the Emergency Deprtment with Pin? y A Grover, MD; Gus M

More information

Introduction. In developing countries, children s weight gain commonly falters in relation to reference data

Introduction. In developing countries, children s weight gain commonly falters in relation to reference data nd feeding of complementry foods ffects mel-specific food consumption nd mel durtion y helthy, rest fed Bngldeshi children M. Munirul Islm 1, Thmeed Ahmed 1, Jnet M. Peerson 2, M. Aid Hossin Mollh 3, Mkhdum

More information

TLR7 induces anergy in human CD4 + T cells

TLR7 induces anergy in human CD4 + T cells TLR7 induces nergy in humn CD T cells Mrgrit Dominguez-Villr 1, Anne-Sophie Gutron 1, Mrine de Mrcken 1, Mrl J Keller & Dvid A Hfler 1 The recognition of microil ptterns y Toll-like receptors (TLRs) is

More information

Start ORKAMBI today. INDICATIONS AND USAGE IMPORTANT SAFETY INFORMATION. Sydney Age 4

Start ORKAMBI today. INDICATIONS AND USAGE IMPORTANT SAFETY INFORMATION. Sydney Age 4 F O R H E A L T H C A R E P R O F E S S I O N A L S For ptients ge 2 yers nd older who re homozygous for the F508del muttion 1,2 Modify the course. Strt tody. Sydney Age 4 F508del/F508del INDICATIONS AND

More information

Intravitreal Triamcinolone Acetonide in Macular Edema due to Retinal Vein Occlusions: A Comparative Study of 1 mg and 4 mg Doses

Intravitreal Triamcinolone Acetonide in Macular Edema due to Retinal Vein Occlusions: A Comparative Study of 1 mg and 4 mg Doses Originl Article DOI: 10.17354/ijss/2015/548 Intrvitrel Trimcinolone Acetonide in Mculr Edem due to Retinl Vein Occlusions: A Comprtive Study of 1 mg nd 4 mg Doses Siknder A K Lodhi 1, Sntosh Devulplly

More information

Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease

Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease Celli et l. Respirtory Reserch 2012, 13:66 RESEARCH Open Access Longitudinl inspirtory cpcity chnges in chronic ostructive pulmonry disese Brtolome R Celli 1*, Mrc Decrmer 2, Theodore Lystig 3, Steven

More information

Diagnostic Accuracy of Mini-Mental Status Examination and Revised Hasegawa Dementia Scale for Alzheimer s Disease

Diagnostic Accuracy of Mini-Mental Status Examination and Revised Hasegawa Dementia Scale for Alzheimer s Disease Originl Reserch Article Dement Geritr Cogn Disord 2005;19:324 330 DOI: 10.1159/000084558 Accepted: Novemer 1, 2004 Pulished online: Mrch 22, 2005 Dignostic Accurcy of Mini-Mentl Sttus Exmintion nd Revised

More information

Prime Enrollees Consumer Watch NHC Patuxent River FY 2016 Defense Health Cost Assessment & Program Evaluation

Prime Enrollees Consumer Watch NHC Patuxent River FY 2016 Defense Health Cost Assessment & Program Evaluation Prime Enrollees Consumer Wtch NHC Ptuxent River 16 Defense Helth Cost Assessment & Progrm Evlution NHC Ptuxent River: Smple size-1,457 Response rte-1.2% Source: Helth Cre Survey of DoD Beneficiries Inside

More information

Research Article Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Research Article Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats Hindwi Pulishing Corportion Evidence-Bsed Complementry nd Alterntive Medicine Volume 212, Article ID 7397, 11 pges doi:1.1155/212/7397 Reserch Article Effect of GCSB-5, Herl Formultion, on Monosodium Iodocette-Induced

More information

Original Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract:

Original Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract: Fridpur Med. Coll. J. 214;9(2):61-67 Originl Article Nebuliztion by Isotonic Mgnesium Sulphte Solution with Provide Erly nd Better Response s Compred to Conventionl Approch ( Plus Norml Sline) in Acute

More information

The Journal of Physiology

The Journal of Physiology J Physiol 595.13 (2017) pp 4379 4398 4379 Impct of perintl exposure to sucrose or high fructose corn syrup (HFCS-55) on diposity nd heptic lipid composition in rt offspring Crl R. Toop 1, Beverly S. Muhlhusler

More information

Chapter 02 Crime-Scene Investigation and Evidence Collection

Chapter 02 Crime-Scene Investigation and Evidence Collection Nme: Clss: Dte: Chpter 02 Crime-Scene Investigtion nd Evidence Collection 1. The terms grid, liner, qudrnt, zone, nd spirl re typiclly used to descrie dtum points... Flse Flse 2. An evidence log nd chin

More information

Thallium-201 chloride scintigraphy in soft tissue tumors

Thallium-201 chloride scintigraphy in soft tissue tumors 136 ORIGINAL Thllium-201 chloride scintigrphy in soft tissue tumors Hideki Otsuk, Kori Terzw, Nomi Morit, Yoichi Otomi, Shoichiro Tko, Seiji Iwmoto, Kyosuke Oski, Msfumi Hrd, nd Hiromu Nishitni Deprtment

More information

Health-Related Quality of Life and Symptoms of Depression in Extremely Obese Persons Seeking Bariatric Surgery

Health-Related Quality of Life and Symptoms of Depression in Extremely Obese Persons Seeking Bariatric Surgery Oesity Surgery, 15, 3-39 Helth-Relted Qulity of Life nd Symptoms of Depression in Extremely Oese Persons Seeking Britric Surgery Anthony N. Frictore, PhD; Thoms A. Wdden, PhD; Dvid B. Srwer, PhD; Myles

More information