IBR-Phyto(flu)ene, COLORLESS CAROTENOIDS TECHNOLOGIY OVERVIEW
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1 PRODUCT CATALOG
2 IBR-Phyto(flu)ene, COLORLESS CAROTENOIDS TECHNOLOGIY OVERVIEW Biologically, carotenoids are an important group of compounds with more than 700 members. are found widely throughout nature, but they are synthesized denovo only by plants, algae, fungi and bacteria where they can aid in the absorbtion of light and the capture of additional energy, which helps neutrize tissue-damaging free radicals (1). Unfortunately, most carotenoids are sensitive to light, a proprty that considerably limits theyr use and shorten the shelf life of products that contain them (2). In addition, almost all carotenoids have a distinctive color, which limits their utility for cosmetic and some food applications. In contrast to all other carotenoids, phytoene and phytofluene, the first carotenoid precursors in the biosynthetic pathway ofother carotenoids, are colorless (or alternatively, lacking visible color) and absorb light in the UV range only. Phytoene has been shown to be anti-carcinogenic in the mouse skin cancer model (3), and experiments performed with phytoene-producing transgenic mice suggest that phytoene mayplay a role in cell-to-cell communication (4). It is important to note that dietary phytoene and phytofluene are accumulated in human skin (5,6). The accumulation of these colorless carotenoids can potentially protect theskin by several mechanisms: acting as UV absorbers, as antioxidants, as anti inflammatory. The distribution of phytoene and phytofluene in human serum, prostate, and skin (6) suggests that phytoene and phytofluene may be responsible for the carotenoid protective effects observed in beauty and skin applications. IBR-Phyto(flu)ene COLORLESS CAROTENOIDS products containing phytoene and phytofluene, naturally produced and/or extracted from special non-gmo tomatoes and algae. The COLORLESS CAROTENOIDS have effective and beneficial activities for beauty applications, specifically in protection against UV and oxidative damage, which is known to lead to pre-mature aging and other phenomena. Able to control pigmentation by inhibition of melanin synthesis, IBR- Phyto(flu)ene COLORLESS CAROTENOIDS lighten the skin. They also present abilities of inflammation reduction, anti oxidation and UVA/UVB protection that enhance skin lightening. Additionally, IBR-Phyto(flu)ene COLORLESS CAROTENOIDS are capable of stabilization, protection and boosting of bio-molecules. Reference 1. A. Bendich, J. A. Olson. Biological actions of carotenoids. FASEB J. 3: (1989) 2. N. I. Krinski, M. M. Matthews-Roth, R. F. Taylor, (Eds), In:, Chemistry and Biology, Planum Press, New York, London. (1989) 3. M. M. Mathews-Roth. Antitumor activity of beta-carotene, canthaxanthin and phytoene. Oncology. 39(1):33-7. (1982) 4. Y. Satomi, N. Misawa, T. Maoka, H. Nishino. Production of phytoene, a carotenoid, and induction of connexin 26 in transgenic mice carrying the phytoene synthase gene crtb. Biocem Biophy Res Comm. 320: (2004) 5. F. Khachik, L. Carvalho, P. S. Bernstein, G. J. Muire, D. Y. Zhao, N. B. Katz. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Exp Biol Med 227: (2002) 6. N. J. Engelmann, S. K. Clinton and J. W. Erdman Jr. Nutritional Aspects of Phytoene and Phytofluene, Carotenoid Precursors to Lycopene. Adv. Nutr. 2: 51-61,
3 IBR-Phyto(flu)ene Colorless Combinations Phytoene & Phytofluene - ß-carotene IBR-AAC Anti Aging - Phytoene, phytofluene and ß-carotene: anti oxidation, anti inflammation, UV protection and pro-retinol addition Phytoene & Phytofluene - Stabilization Boost of SPF Reduce generation of free radicals and damage derived from irradiation of 45 DiHydroxy Acetone Phytoene & Phytofluene - (di hydroxy acetone) Stabilization and protection against degragation Anti oxidants - extending artificial sun tan Omega 3 oils & EPA Phytoene & Phytofluene - Omega 3 oils Stabilization and protection against degragation Reduce peroxide number Combined activities: 1. Prevention of LDL oxidation. 2. Anti aging - anti oxidants, anti inflammatory & protection from UV damage 3. Reduced stretch marks and wrinkles via combined activity of induction of old collagen degradation and enhancement of new collagen synthesis (mostly due to phytoene and phytofluene benefits) 4. Skin protection Phytoene & Phytofluene - Mutual stabilization in emulsions Activities: 1.Combined skin whitening / brightening activity. 2.Oil soluble and water soluble anti oxidants combination. 3.Reduced stretch marks and wrinkles via combined activity of induction of old collagen degradation and enhancement of new collagen synthesis Phytoene & Phytofluene - Combined effect of short and long term anti aging activities IBR-Phyto(flu)ene TM anti oxidation >> maintaining collagen levels UV protection >> DNA damage prevention Slowing down aging: via dormancy Control of cell proliferation. Combined effects on skin whitening / brightening Inhibition of melanocytes proliferation Inhibition of melanin synthesis. DiHydroxy Acetone Omega 3 oils & EPA IBR-CLC Beauty from the inside* and outside Anti aging and photo-aging Skin brightening/whitening evening of skin tone Protection against UV and its damage Colorless carotenoids: Phytoene & Phytofluene Efficacy Protection and stability Synergism Boosting activity Anti oxidant DNA damage prevention Anti inflammatory Protection and enhancement of stability and function of various active ingredients Tio mg/ml P&P Tio mg/ml P&P 0.25 % Tio2 Phytoene & Phytofluene - Stabilize and Boost & Phyto(flu)ene (after sun) % phenol after UVA irradiation Effect of phytoene and phytofluene (P&P) on phenol stability following UVA irradiation of TiO2 Phytoene & Phytofluene - Synergism Anti Aging via: & Phyto(flu)ene (before sun) (after sun) 1. Reduced MMP-1 expression* 2. Reduced inflammation - PGE-2* Anti Aging via reduction of fatigue and stress 1 2 *Fuller B.B., et al. J. Cos. Der March. 5 (1):30 Phytoene & Phytofluene - A. 5% 0.5% IBR-Phyto(flu)ene B. 0.1% 0.05% IBR-Phyto(flu)ene Time: 0 A Time: 10 (before sun) Stabilization of avobenzone (1.67%) by Phyto(flu)ene % following 10 minutes exposure to sunlight, an in vitro study performed in duplicates B levels in cream after 4 weeks 0.5% IBR-Phyto(flu)ene = 93% or 0.05% BHT = 68% B 100 A % of retained 27
4 NEW CONCEPT IBR-Phyto(flu)ene The Colorless A Perfect Skin Supplement to stabilize, boost and support broad-spectrum sunscreen, sun protection and care. DiHydroxy Acetone Omega 3 oils & EPA IBR-CLC Colorless carotenoids: Phytoene & Phytofluene Efficacy Protection and stability Synergism Boosting activity 28
5 Beauty from inside and outside IS COUPLED IBR-Phyto(flu)ene : & PhytoflORAL Beauty Inside and Outside with Phytoene & phytofluene, The Colorless IBR-Phyto(flu)ene Products are a Perfect Skin Supplement from Within and Outside for the Support of Skin Anti Aging Capabilities, Protection and Care Against Sun as well as lighter and Even Skin Tone 29
ABSTRACT. 1 P age LIKI VON OPPEN-BEZALEL, OLGA BEN-CHITRIT, FABIEN HAVAS, DANIT FISHBEIN IBR LTD.
IBR CLEARLY BRIGHT Complex with Phyto(flu)ene the COLORLESS CAROTENOIDS, IBR-Dormin and IBR-Snowflake for better, outstanding Skin Lightening, Whitening & Evening of Skin Tone LIKI VON OPPEN-BEZALEL, OLGA
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