Strategies for preventing and treating IFALD

Size: px
Start display at page:

Download "Strategies for preventing and treating IFALD"

Transcription

1 Strategies for preventing and treating IFALD Dr Sue Beath The Liver Unit (including small bowel transplantation) Birmingham Children s Hospital

2 Intestinal failure associated liver disease IFALD in children is a manifestation of a systemic inflammatory response syndrome (SIRS) often triggered by sepsis Scenarios which increase the intensity of SIRS surgery invasive care NICU/PICU Also known as Parenteral Nutrition Associated Cholestastis (PNAC), but IFALD is to be preferred as it focuses attention on the whole context of intestinal failure and not just the PN infusions

3 Why worry about intestinal failure associated liver disease over 1000 children on PN per year and at risk of IFALD about half have abnormal liver function of those who are referred for small bowel transplant half have advanced liver disease (type IFALD; bilirubin >100 micromol/l) IFALD (esp type ) increases the risk of mortality neonates and children are more susceptible to IFALD than adults liver transplantation is an option but v. high risk in context of IF

4 Pathophysiology of IFALD = twin process 1. Exogenous factors bacterial endotoxin [Klosters] and necrotising enterocolitis pro-inflammatory mediators cytotoxic reactions disruption of biliary system transporters by endotoxin, cytokines excess nutrients overwhelming normal metabolic processes 2. Endogenous patient related factors prematurity and immature homeostatic mechanisms [Hermans, Beath, Robinson, Hsieh] malnutrition - depletion of innate detoxifiers glutathione portals of entry for infection (ITU +/- surgery) Necrotising enterocolitis [Duro] Gastroschisis [Dell Olio]

5 IFALD literature review The following search terms were used to identify published reports: Intestinal failure associated liver disease (n= 4) Parenteral Nutrition Associated Cholestastis (n=18) Liver disease and intestinal failure (n=1177; 277 reviews, 20 remained after excluding non-human, or adult focused papers and papers previously identified by the earlier search terms). 5 reports where IFALD or PNAC was the main focus

6 Evidence level assigned according to the SIGN criteria 4 = EL 1 randomised controlled studies [Harbour & Miller] 1 = EL 2 cohort studies, non randomised interventions 16 = EL surveys, non -experimental The subjects of the papers were in the following categories: IFALD improved or prevented by drugs IFALD improved or prevented by modifications to the PN solution IFALD improved by good clinical practice

7 Drug treatment of IFALD Reference Evidence level 1.High dose (12.5mg/kg/dose) oral erythromycin for dysmotility in babies Ng et al Ursodeoxycholic acid 0mg/kg/day prevents IFALD type 1 (bilirubin <50µmol/l) and improves established IFALD (types 2 & ).Cholecystokin is not useful in preventing IFALD in noenates 4. Metronidazole 25-50mg/kg/day prevents IFALD type 1 and reduces type IFALD Arslanoglu 2008 Chen 2004 De Marco 2006 Teitlebaum 2005 Kubota Sigalet 1 1

8 IFALD improved or prevented by modifications to the PN solution 1. reducing soya based oil in PN a) makes no difference to LFTs in infants on long term PN b) improves cholestasis in children older than 6 months 2. using lipid PN enriched with fish oil improves IFALD: omegaven omegaven omegaven SMOF Lipid Reference Goulet 1999 Rollins 2010 Siaglet Puder Gura None in children ESPGHAN guidance Evidence level. limiting lipid in PN to less 4 than.5mg/kg/d 4. Cycling PN reduced risk of IFALD Jensen Taurine supplements prevents Type 1 and reduces type IFALD in NEC Spencer 2009

9 Risk factor for IFALD and good clinical practice Reference Prematurity Fitzgibbons 2010 Robinson 2008 Hsieh 2009 Beath 1996 Evidence level Need for abdominal surgery Duro 2011 Need for stoma Andorsky 2001 Less than 0cm small bowel Peyret 2011 History of gastroschisis and dsymotility History of severe NEC Robinson 2008 Early colonisation with pseudomonas or enterobacter CRBSI within 28 days of birth Hermans 2007 Sondheimer 1998 Recurrent CRBSI Beath 1996 Hsieh 2009 Wales 2005 Andorsky 2001 Dell Olio 2009 Duro 2011 Pierro 1998

10 medical management algorithms for IFALD a) with IFALD nil or mild type 1 IFALD b) worsening IFALD (type 2/) Abnormal LFTs; bilirubin rising Abn LFTs; bilirubin >50mmol/dL 1. Screen for infection and primary liver disease 2. Start antibiotics if infection likely. Commence enteral nutrition (EN) unless concerns about NEC & erythromycin [Ng] 4. Start ursodeoxycholic acid p.o. [Arslanoglu] 5. Start cycling PN asap 6. Use amino acid solns with taurine supplements [Spencer] 7. Discuss with PN prescription with NST 1. Screen for infection, consider replacement of feeding catheter. 2. Review hygiene measures for feeding catheter.. reduce over exposure to PN calories [ESPGHAN] 4. Consider second line iv lipid with reduced Linolenic acid. 5. Consider surgical strategies to enhance intestinal rehab &EN. 6. Treat bacterial overgrowth 7. Stop intravenous lipid infusion for 1-2 weeks

11 Neonatal and surgical management algorithms in IFALD Abnormal LFTs in surgical neonates 1.Screen for infection and liver disease 2.Start antibiotics if infection likely.screen and treat for intestinal obstruction 4.Restore intestinal continuity at an opportunity 5.Discuss with NST to reduce over exposure to PN calories. 6.Start Ursodeoxycholic acid 0mg/day early Neonate or infant with high nasogastic losses Screen for and treat intestinal obstruction. Treat dysmotilty with high dose oral erythromycin 12.5mg/kg/dose [Ng] Worsening IFALD 1.Discuss with NST to reduce over exposure to PN calories 2.Consider surgical strategies to enhance intestinal rehabilitation inc restoration of bowel continuity. Children older than 6 months.bowel lengthening and tapering may be an option 4.Review hygiene measures for feeding catheter and consider replacement of feeding catheter

12 IFALD in setting of long term intestinal failure 1. Discharge to home with NST supporting care of Home PN [Puntis, Hess] 2. Review prescription to reduce over exposure to PN calories [ESPGHAN]. Introduce lipid free days / Consider alternative type of PN lipid 4. Screen for infection and treat as indicated, consider replacement of feeding catheter. 5. Consider alternative type of PN lipid If IFALD worsens or does not resolve Consult specialist centre for suitability of liver +/- small bowel transplant

13 Currently the only EL 1 studies in IFALD are: High-dose oral erythromycin (12.5 mg/kg/dose) to be used as a rescue measure for VLBW infants who fail to establish adequate EN and in whom intestinal obstruction has been excluded EL1+ Ng 2007 UDCA p.o. should be routinely administered to infants who are receiving minimal oral/enteral feeding EL1+ Arslanoglu 2008 Cholecystokin is not useful in preventing IFALD in neonates EL1++ Teitlebaum 2005 Reducing soya based oil in lipid component of PN makes no difference to LFTs in infants on long term PN EL1- Goulet 1999

14 Reference Population Ng PC Gastroent 2007 Arslanoglu S JPGN 2008 Teitlebuam DH Pediatrics 2005 Goulet O Am J Clin Nutr 1999 VLBW infants recruited from 1 centre in Hong Kong Pre-term infants recruited from 1 centre in Milan Neonates recruited from 8 neonatal tertiary care centres in USA Infants on long term PN Recruited from Intervention Cases Control data High dose 91 Double oral 12.5mg blinded erythromycin randomized from day control s 15 placebo 91 controlled UDCA for wks from birth CCK-OP 0.04microg ram /kg/dose Olive oil vs. soy bean lipid 15 control s control s control s 9 study Double blind placebo control Double blinded randomized placebo control Randomiz -ed eligible patients Study rating Outcomes reported 1++ The treatment group had a lower frequency of IFALD (18/91 vs 7/91 p=0.00); shorter duration of PN (2 versus days p<0.001), septacaemic episodes >2 reduced in treatment group (p=0.0) 1+ Significant reduction of GGT in treated group, trend to earlier weaning from PN and reduced fat excretion. 1++ CCK-OP did not reduce incidence of IFALD 1- No significant diff in bilirubin. ALT. AST. Sign treatment effect on total cholesterol and LDL

15 Parenteral nutrition in pre-term babies and infants a Decision Tree Is Intestinal failure likely >28 days? Is the GI tract functioning sufficiently for absorption of some nutrients? Yes No Continue PN, either as an alternative, or a supplement, if clinically appropriate and re-challenge with EN later Has oro/naso/gastric feeding +/- erythromycin been attempted? 1 Has ursodeoxycholic acid 0mg/kg been started? 2 Consider erythromycin if clinically appropriate eg if dysmotile but no evidence of intestinal obstruction Ng PC, et al High-dose oral erythromycin decreased the incidence of parenteral nutritionassociated cholestasis in preterm infants. Gastroenterology. 2007;12: Arslanoglu S et al Ursodeoxycholic acid treatment in preterm infants: a pilot study for the prevention of cholestasis associated with total parenteral nutrition. J Pediatr Gastroenterol Nutr. 2008;46: Guidelines on paediatric parenteral nutrition J Pediatr Gastroenterol Nutr 2005;41;suppl 4. Sigalet D et Improvd outcomes in paediatric intestinal failure with aggressive prevention of liver disease. Eur J Pedaitr Surg 2009; 19: 48-5.

16 Parenteral nutrition in pre-term babies and infants a Decision Tree Is Intestinal failure likely >28 days? Are liver function tests normal? Yes No Continue PN with monitoring (glucose, trace elements etc) and re-consider weaning with EN Consider: 1.Screen for infection, consider replacement of feeding catheter. 2.Review hygiene measures for feeding catheter..reduce over exposure to PN calories [ESPGHAN] 4.Consider second line iv lipid with reduced Linolenic acid 4. 5.Consider surgical strategies to enhance intestinal rehab & EN. 6.Treat bacterial overgrowth 7.Stop intravenous lipid for 1-2 weeks 8.exclude congenital liver disease 1. Ng PC, et al High-dose oral erythromycin decreased the incidence of parenteral nutritionassociated cholestasis in preterm infants. Gastroenterology. 2007;12: Arslanoglu S et al Ursodeoxycholic acid treatment in preterm infants: a pilot study for the prevention of cholestasis associated with total parenteral nutrition. J Pediatr Gastroenterol Nutr. 2008;46: Guidelines on paediatric parenteral nutrition J Pediatr Gastroenterol Nutr 2005;41;suppl 4. Sigalet D et Improvd outcomes in paediatric intestinal failure with aggressive prevention of liver disease. Eur J Pedaitr Surg 2009; 19: 48-5.

17 Research Recommendations in IFALD Multicentre studies needed to achieve recruitment of 50+ subjects for: Multi-source lipids in cognitive and hepatic outcomes Erythromycin as a treatment for dysmotility in term infants and high risk groups eg in gastroschisis Biochemical markers of liver fibrosis Treatments which reduce CRBSI which is an important factor in IFALD (eg line locks) in hospitalized and home PN patients

PARENTERAL NUTRITION- ASSOCIATED LIVER DISEASE IN CHILDREN

PARENTERAL NUTRITION- ASSOCIATED LIVER DISEASE IN CHILDREN PARENTERAL NUTRITION- ASSOCIATED LIVER DISEASE IN CHILDREN Praveen Goday MBBS CNSC Associate Professor Pediatric Gastroenterology Medical College of Wisconsin Milwaukee, WI Parenteral Nutrition-Associated

More information

Hepatoprotective Therapies for TPN-Associated Cholestasis

Hepatoprotective Therapies for TPN-Associated Cholestasis Hepatoprotective Therapies for TPN-Associated Cholestasis Robert A. Cowles, M.D. Department of Surgery Columbia University Medical Center and Morgan Stanley Children s Hospital New York, NY USA For the

More information

Advances in intestinal Rehabilitation Susan Hill Gastroenterology Consultant

Advances in intestinal Rehabilitation Susan Hill Gastroenterology Consultant Advances in intestinal Rehabilitation Susan Hill Gastroenterology Consultant 2 Indication for intravenous nutrition/pn: Intestinal Failure Inability to maintain weight and growth despite adequate enteral

More information

What s s up with Omegaven????? Kathleen Gura PharmD Children s s Hospital Boston

What s s up with Omegaven????? Kathleen Gura PharmD Children s s Hospital Boston What s s up with Omegaven????? Kathleen Gura PharmD Children s s Hospital Boston Disclosures Funding : March of Dimes FDA Orphan Drug Grants Program NIH Children s s Hospital Surgical Foundation Patent

More information

Managing abnormal LFTs

Managing abnormal LFTs Managing abnormal LFTs Dr Simon Gabe Consultant Gastroenterologist St Mark s Hospital It depends Short Long Questions How common are abnormal LFTs in patients on IVN? Is it the parenteral nutrition? Short

More information

Nutritional Requirements in Intestinal Failure

Nutritional Requirements in Intestinal Failure Nutritional Requirements in Intestinal Failure Christopher Duggan, MD, MPH Center for Nutrition Center for Advanced Intestinal Rehabilitation (CAIR) Division of Gastroenterology, Hepatology and Nutrition

More information

PARENTERAL NUTRITION

PARENTERAL NUTRITION PARENTERAL NUTRITION DEFINITION Parenteral nutrition [(PN) or total parenteral nutrition (TPN)] is the intravenous infusion of some or all nutrients for tissue maintenance, metabolic requirements and growth

More information

DISCLOSURE. Learning Objectives. Controversies in Parenteral Nutrition

DISCLOSURE. Learning Objectives. Controversies in Parenteral Nutrition Controversies in Parenteral Nutrition Christopher Duggan, MD, MPH Center for Nutrition Center for Advanced Intestinal Rehabilitation (CAIR) Division of Gastroenterology, Hepatology and Nutrition Boston

More information

Fish oil based lipid emulsion s role in transitioning pediatric patients from plant based to combination plant and fish oil based lipid emulsion

Fish oil based lipid emulsion s role in transitioning pediatric patients from plant based to combination plant and fish oil based lipid emulsion Fish oil based lipid emulsion s role in transitioning pediatric patients from plant based to combination plant and fish oil based lipid emulsion Kayley Liuzzo, PharmD PGY 1 Pharmacy Practice Resident Children

More information

Intestinal Rehabilitation and Transplantation

Intestinal Rehabilitation and Transplantation Intestinal Rehabilitation and Transplantation Joel Lim, MD Associate Professor of Pediatrics Children s Mercy Hospital University of Missouri in Kansas City Objective: Intestinal Failure/Short Bowel Syndrome

More information

Effect of changing lipid formulation in Parenteral Nutrition in the Newborn Experimental Pathology BSc

Effect of changing lipid formulation in Parenteral Nutrition in the Newborn Experimental Pathology BSc Effect of changing lipid formulation in Parenteral Nutrition in the Newborn Experimental Pathology BSc Word count: 6939 0 CONTENTS Abstract...2 Acknowledgements...3 Introduction...4 Materials and Methods...11

More information

Short Bowel Syndrome: Medical management

Short Bowel Syndrome: Medical management Short Bowel Syndrome: Medical management La Sindrome dell'intestino Corto in età pediatrica Brescia 18 marzo 2011 Jon A.Vanderhoof, M.D. Division of Pediatric GI Harvard Medical School Children s Hospital,

More information

3/26/18. Total Parenteral Nutrition Roundtable Discussion. Disclosure Information. Objectives. Monitoring Parameters & Complications

3/26/18. Total Parenteral Nutrition Roundtable Discussion. Disclosure Information. Objectives. Monitoring Parameters & Complications Total Parenteral Nutrition Roundtable Discussion Monitoring Parameters & Complications Jessica Pech MSN, APN, CPNP-PC Division of Pediatric Surgery Ann & Robert H. Lurie Children's Hospital of Chicago

More information

Improved survival in a multidisciplinary short bowel syndrome program

Improved survival in a multidisciplinary short bowel syndrome program Journal of Pediatric Surgery (2008) 43, 20 24 www.elsevier.com/locate/jpedsurg Improved survival in a multidisciplinary short bowel syndrome program Biren P. Modi a,b, Monica Langer a,b, Y. Avery Ching

More information

Intravenous Lipids: Clinical & Practical Updates. Nora AlBanyan, R.Ph., SSC-PhP, SSCPN, BCNSP

Intravenous Lipids: Clinical & Practical Updates. Nora AlBanyan, R.Ph., SSC-PhP, SSCPN, BCNSP Intravenous Lipids: Clinical & Practical Updates Nora AlBanyan, R.Ph., SSCPhP, SSCPN, BCNSP Disclosure Information I have no financial relationship to disclose. AND I will not discuss off label use and/or

More information

Symposium 3. Pre-term Infant in the First Week of Life

Symposium 3. Pre-term Infant in the First Week of Life Symposium 3 Fl id d N t iti S t f th Fluid and Nutrition Support of the Pre-term Infant in the First Week of Life The choice of lipid in the preterm infant practice and controversy Susan Hill Department

More information

Guideline scope Neonatal parenteral nutrition

Guideline scope Neonatal parenteral nutrition NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Guideline scope Neonatal parenteral nutrition The Department of Health in England has asked NICE to develop a new guideline on parenteral nutrition in

More information

Who Needs Parenteral Nutrition? Is Parenteral Nutrition An Appropriate Intervention?

Who Needs Parenteral Nutrition? Is Parenteral Nutrition An Appropriate Intervention? Who Needs Parenteral Nutrition? 1 Is Parenteral Nutrition An Appropriate Intervention? Key questions to ask with initial consultation Can the gastrointestinal (GI) tract be utilized? Can the GI tract be

More information

Disclosures. Objectives. Long-term complications of TPN

Disclosures. Objectives. Long-term complications of TPN Long-term complications of TPN Now that my intestinal failure patients are not dying of liver disease, what else should I worry about? Jane P. Balint, MD Co-director, Intestinal Support Service Nationwide

More information

ESPEN Congress Geneva 2014 NUTRITION IN PAEDIATRIC PATIENTS 2. Nutrition treatment in children with intestinal failure S.

ESPEN Congress Geneva 2014 NUTRITION IN PAEDIATRIC PATIENTS 2. Nutrition treatment in children with intestinal failure S. ESPEN Congress Geneva 2014 NUTRITION IN PAEDIATRIC PATIENTS 2 Nutrition treatment in children with intestinal failure S. Kolaček (HR) Nutrition treatment in children with intestinal failure - IF special

More information

Is NEC requiring surgery precipitated by a change in feeds? Observations from 50 consecutive cases. David Burge SIGNEC September 2015

Is NEC requiring surgery precipitated by a change in feeds? Observations from 50 consecutive cases. David Burge SIGNEC September 2015 Is NEC requiring surgery precipitated by a change in feeds? Observations from 50 consecutive cases. David Burge SIGNEC September 2015 Clinical series Specific cases Other scenarios Published experience

More information

Parenteral nutrition associated cholestasis: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review

Parenteral nutrition associated cholestasis: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review Journal of Pediatric Surgery (2012) 47, 225 240 www.elsevier.com/locate/jpedsurg Review articles Parenteral nutrition associated cholestasis: an American Pediatric Surgical Association Outcomes and Clinical

More information

Gastroschisis Sequelae and Management

Gastroschisis Sequelae and Management Gastroschisis Sequelae and Management Mary Finn Gillian Lieberman, MD Primary Care Radiology Beth Israel Deaconess Medical Center Harvard Medical School April 2014 Outline I. Definition and Epidemiology

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Index Note: Page numbers of article titles are in boldface type. A Acetate, in pediatric surgical patients, 525 526 Acute respiratory distress syndrome (ARDS), immune-modulating nutrition in, 584 585 Aerobic

More information

Management of Short Bowel Syndrome in the Era of Teduglutide. Charlene Compher, PhD, RD University of Pennsylvania

Management of Short Bowel Syndrome in the Era of Teduglutide. Charlene Compher, PhD, RD University of Pennsylvania Management of Short Bowel Syndrome in the Era of Teduglutide Charlene Compher, PhD, RD University of Pennsylvania compherc@nursing.upenn.edu Disclosures Research funding for clinical trials by NPS Pharmaceuticals

More information

TRANSPARENCY COMMITTEE OPINION. 19 March Date of the Marketing Authorisation (national procedure): 18 December 1997

TRANSPARENCY COMMITTEE OPINION. 19 March Date of the Marketing Authorisation (national procedure): 18 December 1997 The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 19 March 2008 INTRALIPIDE 20 PER CENT, emulsion for infusion 100 ml in Excel container (PE/PP) (CIP: 355 096-5) 250

More information

Minimal Enteral Nutrition

Minimal Enteral Nutrition Abstract Minimal Enteral Nutrition Although parenteral nutrition has been used widely in the management of sick very low birth weight infants, a smooth transition to the enteral route is most desirable.

More information

Surgery for Intestinal Failure

Surgery for Intestinal Failure Surgery for Intestinal Failure Kishore Iyer, MBBS, FRCS (Eng), FACS Director, Adult & Pediatric Intestinal Transplantation Associate Professor of Surgery & Pediatrics Mount Sinai School of Medicine New

More information

Resuscitating neonatal and infant organs and preserving function. GI Tract and Kidneys

Resuscitating neonatal and infant organs and preserving function. GI Tract and Kidneys Resuscitating neonatal and infant organs and preserving function GI Tract and Kidneys Australian and New Zealand Resuscitation Council Joint Guidelines Outline Emphasis on the infant - PICU Kidney Gastrointestinal

More information

Improved Outcomes in Paediatric Intestinal Failure with Aggressive Prevention of Liver Disease

Improved Outcomes in Paediatric Intestinal Failure with Aggressive Prevention of Liver Disease 348 Original Article Improved Outcomes in Paediatric Intestinal Failure with Aggressive Prevention of Liver Disease Authors D. Sigalet 1, D. Boctor 2, M. Robertson 2, V. Lam 3, M. Brindle 4, K. Sarkhosh

More information

INTESTINAL FAILURE, REHABILITATION & TRANSPLANTATION: Indications, Techniques and Outcomes

INTESTINAL FAILURE, REHABILITATION & TRANSPLANTATION: Indications, Techniques and Outcomes INTESTINAL FAILURE, REHABILITATION & TRANSPLANTATION: Indications, Techniques and Outcomes Douglas G. Farmer, MD. Professor of Surgery Director, Intestinal Transplant Program Dumont-UCLA Transplant Center

More information

Early Life Nutrition: Feeding Preterm Babies for Lifelong Health

Early Life Nutrition: Feeding Preterm Babies for Lifelong Health Early Life Nutrition: Feeding Preterm Babies for Lifelong Health Jane Alsweiler Frank Bloomfield Anna Tottman Barbara Cormack Tanith Alexander Jane Harding Feeding Preterm Babies for Lifelong Health Why

More information

Challenges in Pediatric Nutritional Support. Donald E. George, MD

Challenges in Pediatric Nutritional Support. Donald E. George, MD Challenges in Pediatric Nutritional Support Donald E. George, MD What is so special about Kids They Grow They Change They Explore They Frequently get better What is so special about Kids They require more

More information

PROTOCOL FOR PARENTERAL NUTRITION

PROTOCOL FOR PARENTERAL NUTRITION PROTOCOL FOR PARENTERAL NUTRITION Based on; Roberton s textbook of neonatology. 4 th edition. 2005. Sudha Chaudari and Sandeep Kumar.TPN in neonates. Indian Paediatrics. November 2006 Deepak Chawla, Anu

More information

10/3/2012. Pediatric Parenteral Nutrition A Comprehensive Review

10/3/2012. Pediatric Parenteral Nutrition A Comprehensive Review Critical Care Nutrition Foundation for Moving Forward Justine Turner MD PhD Department of Pediatric Gastroenterology and Nutrition University of Alberta I have the following financial relationships to

More information

Nutritional Issues in Cholestatic Disease

Nutritional Issues in Cholestatic Disease THE HOSPITAL FOR SICK CHILDREN Nutritional Issues in Cholestatic Disease NASPGHAN-CPNP Joint Session Binita M. Kamath, MBBChir MRCP MTR Associate Professor Division of Gastroenterology, Hepatology and

More information

THE INTRODUCTION OF PARenteral

THE INTRODUCTION OF PARenteral REVIEW ARTICLE Parenteral Fish Oil Monotherapy in the Management of Patients With Parenteral Nutrition Associated Liver Disease Vincent E. de Meijer, MD, MSc; Kathleen M. Gura, PharmD; Jonathan A. Meisel,

More information

Use of Fish Oil Emulsion in Parenteral Nutrition: A Review of 20 Cases

Use of Fish Oil Emulsion in Parenteral Nutrition: A Review of 20 Cases 503986CANXXX10.1177/1941406413503986ICAN: Infant, Child, & Adolescent NutritionICAN: Infant, Child, & Adolescent Nutrition research-articlexxxx ICAN: Infant, Child, & Adolescent Nutrition February 2014

More information

PAEDIATRIC PARENTERAL NUTRITION. Ezatul Mazuin Ayla binti Mamdooh Waffa Hospital Sultanah Aminah

PAEDIATRIC PARENTERAL NUTRITION. Ezatul Mazuin Ayla binti Mamdooh Waffa Hospital Sultanah Aminah PAEDIATRIC PARENTERAL NUTRITION Ezatul Mazuin Ayla binti Mamdooh Waffa Hospital Sultanah Aminah Johor Bahru Malnutrition INTRODUCTION pathologic state of varying severity with clinical features caused

More information

Sustain Follow-up Data Collection Form (Revised 2/4/2014) (both pediatric and adult elements) (Please select) (Please select)

Sustain Follow-up Data Collection Form (Revised 2/4/2014) (both pediatric and adult elements) (Please select) (Please select) Patient Information Sustain Follow-up Data Collection Form (Revised 2/4/2014) (both pediatric and adult elements) Visit Date Patient Birth Date -- Gender (please select) What is the nature of this follow-up?

More information

Intestinal failure and long-term parenteral nutrition in children

Intestinal failure and long-term parenteral nutrition in children paediatric nursing December 2008 vol 20 no 10 37 Intestinal failure and long-term parenteral nutrition in children PN195 Claire Sadlier (2008) Long-term parenteral nutrition. Paediatric Nursing. 20, 10,

More information

SUSTAIN BASELINE DATA COLLECTION FORM. Revised 2/4/2014 (both pediatric and adult data elements) 1. Gestational age at birth ( weeks gestation)

SUSTAIN BASELINE DATA COLLECTION FORM. Revised 2/4/2014 (both pediatric and adult data elements) 1. Gestational age at birth ( weeks gestation) SUSTAIN BASELINE DATA COLLECTION FORM Patient Demographics Revised 2/4/2014 (both pediatric and adult data elements) Did the patient begin Home PN over 90 days ago? Yes No Date began Home PN Patient Number

More information

Clinical Guideline: Parenteral Feeding of Infants on the Neonatal Unit.

Clinical Guideline: Parenteral Feeding of Infants on the Neonatal Unit. Clinical Guideline: Parenteral Feeding of Infants on the Neonatal Unit. Authors: Lynne Radbone, Lead Dietitian, East of England Perinatal Network/ Principal Paediatric Dietitian Dr Jennifer Birch, Consultant

More information

BACTERIAL TRANSLOCATION AND INTESTINAL PERMEABILITY IN PRETERM INFANTS

BACTERIAL TRANSLOCATION AND INTESTINAL PERMEABILITY IN PRETERM INFANTS BACTERIAL TRANSLOCATION AND INTESTINAL PERMEABILITY IN PRETERM INFANTS Dr Paul Fleming Consultant Neonatal Medicine Homerton University Hospital Honorary Research Fellow Barts and the London School of

More information

PAEDIATRIC PARENTERAL NUTRITION - INDIAN CONTEXT. Dr. Sarath Gopalan

PAEDIATRIC PARENTERAL NUTRITION - INDIAN CONTEXT. Dr. Sarath Gopalan PAEDIATRIC PARENTERAL NUTRITION - INDIAN CONTEXT Dr. Sarath Gopalan Senior Consultant in Pediatric Gastroenterology, Hepatology Indraprastha Apollo Hospital, New Delhi PN DELIVERY CENTRAL PERIPHERAL

More information

Neonatal Cholestasis. What is Cholestasis? Congenital and Pediatric liver diseases 4/26/18

Neonatal Cholestasis. What is Cholestasis? Congenital and Pediatric liver diseases 4/26/18 Congenital and Pediatric liver diseases Nitika Gupta, M.D. Personal/Professional Financial Relationships with Industry in the past year External Industry Relationships * Equity, stock, or options in biomedical

More information

Prolonged Neonatal Jaundice

Prolonged Neonatal Jaundice Prolonged Neonatal Jaundice Ahmed Laving KPA Annual Scientific Conference 2018 Prolonged Jaundice? >6 months >3 months >2 weeks >4 weeks Prolonged Jaundice? >6 months >3 months >2 weeks >4 weeks Case Presentation

More information

Drug Shortages with Parenteral Nutrition

Drug Shortages with Parenteral Nutrition Drug Shortages with Parenteral Nutrition Carol J Rollins, MS, RD, PharmD, BCNSP Coordinator, Nutrition Support Team The University of Arizona Medical Center www.nutritioncare.org Conflict of Interest None

More information

Nutrition in the NICU ANDI MARKELL RD, LD

Nutrition in the NICU ANDI MARKELL RD, LD Nutrition in the NICU ANDI MARKELL RD, LD PORTLAND, OREGON ANDI MARKELL NUTRITION CONSULTANT Conflict of Interest I had no conflict of interest until 2015 when I was asked to join the Nutrition Advisory

More information

Nutrition in the premie World

Nutrition in the premie World SURVIVAL AND GROWTH NUTRITION ESSENTIALS Nutrition in the premie World DR VISH SUBRAMANIAN MD MRCP (UK) FAAP NEONATAL CRITICAL CARE MERCY CHILDRENS HOSPITAL., SPRINGFIELD MO Prematurity Nutritional Requirements

More information

4/15/2014. Nurses Take the Lead to Improve Overall Infant Growth. Improving early nutrition. Problem Identification

4/15/2014. Nurses Take the Lead to Improve Overall Infant Growth. Improving early nutrition. Problem Identification Nurses Take the Lead to Improve Overall Infant Growth Cathy Lee Leon, RN, BSN, MBA, NE-BC California Pacific Medical Center-San Francisco Improving early nutrition Standardized feeding protocol Problem

More information

ESPEN Congress The Hague 2017

ESPEN Congress The Hague 2017 ESPEN Congress The Hague 2017 Meeting nutritional needs of acute care patients Feeding acute pancreatitis patients J. Luttikhold (NL) FEEDING ACUTE PANCREATITIS PATIENTS Joanna Luttikhold, MD PhD Registrar

More information

SHORT GUT SYNDROME (SGS) : A MANAGEMENT CHALLENGE!

SHORT GUT SYNDROME (SGS) : A MANAGEMENT CHALLENGE! SHORT GUT SYNDROME (SGS) : A MANAGEMENT CHALLENGE! Muhammad Saaiq DEPARTMENT OF SURGERY,PIMS, ISLAMABAD. Surgical Grand Round, Pakistan Institute of Medical Sciences (PIMS), Islamabad. September 23, 2005.

More information

MCT AND THE ROLES NUTRITION

MCT AND THE ROLES NUTRITION MCT AND THE ROLES NUTRITION Nguyen Hoang Nhut Hoa Department of Nutrition Children's Hospital 2 OBJECTIVES Structure Absorption and metabolic Effects of MCT in the treatment of certain diseases Demand

More information

Intravenous Lipid Emulsions for Parenteral Nutrition: What Choices Do We Have?

Intravenous Lipid Emulsions for Parenteral Nutrition: What Choices Do We Have? Intravenous Lipid Emulsions for Parenteral Nutrition: What Choices Do We Have? Cynthia L. Lieu, Pharm.D., BCNSP Nutrition Support Pharmacist, LAC+USC Medical Center Associate Professor of Clinical Pharmacy

More information

SWISS SOCIETY OF NEONATOLOGY. Spontaneous intestinal perforation or necrotizing enterocolitis?

SWISS SOCIETY OF NEONATOLOGY. Spontaneous intestinal perforation or necrotizing enterocolitis? SWISS SOCIETY OF NEONATOLOGY Spontaneous intestinal perforation or necrotizing enterocolitis? June 2004 2 Stocker M, Berger TM, Neonatal and Pediatric Intensive Care Unit, Children s Hospital of Lucerne,

More information

Nutrition in the preterm - current menu Dr Heena Hooker Consulting Neonatal Paediatrician Aga Khan University Hospital, Nairobi

Nutrition in the preterm - current menu Dr Heena Hooker Consulting Neonatal Paediatrician Aga Khan University Hospital, Nairobi Nutrition in the preterm - current menu Dr Heena Hooker Consulting Neonatal Paediatrician Aga Khan University Hospital, Nairobi Outline O Background O Challenges in preterm nutrition O Parenteral Nutrition

More information

11/4/10. Making Sense of Infant Formulas, Milk Fortifiers and Additives. Components of infant formula. Goals of Growth.

11/4/10. Making Sense of Infant Formulas, Milk Fortifiers and Additives. Components of infant formula. Goals of Growth. Components of infant formula Making Sense of Infant Formulas, Milk Fortifiers and Additives Jae Kim, MD, PhD UCSD Medical Center Division of Neonatal-Perinatal Medicine Division of Pediatric Gastroenterology,

More information

Parenteral Nutrition

Parenteral Nutrition Approved by: Parenteral Nutrition Gail Cameron Senior Director Operations, Maternal, Neonatal & Child Health Programs Dr. Paul Byrne Medical Director, Neonatology Neonatal Policy & Procedures Manual :

More information

NEC- What Lies Under the Big Umbrella?

NEC- What Lies Under the Big Umbrella? NEC- What Lies Under the Big Umbrella? Instructor in Surgery Associate Surgical Director, Center for Advanced Intestinal Rehabilitation Department of Surgery, Boston Children's Hospital Harvard Medical

More information

pissn: , eissn: Yonsei Med J 54(4): , 2013

pissn: , eissn: Yonsei Med J 54(4): , 2013 Original Article http://dx.doi.org/10.3349/ymj.2013.54.4.839 pissn: 0513-5796, eissn: 1976-2437 Yonsei Med J 54(4):839-844, 2013 Parenteral Nutrition Associated Cholestasis Is Earlier, More Prolonged and

More information

Ontario s Paediatric Referral and Listing Criteria for Small Bowel and Liver- Small Bowel Transplantation

Ontario s Paediatric Referral and Listing Criteria for Small Bowel and Liver- Small Bowel Transplantation Ontario s Paediatric Referral and Listing Criteria for Small Bowel and Liver- Small Bowel Transplantation Version 3.0 Trillium Gift of Life Network Ontario s Paediatric Referral and Listing Criteria for

More information

Małgorzata Łyszkowska

Małgorzata Łyszkowska Małgorzata Łyszkowska Department of Paediatric Surgery and Organ Transplantation The Children s Memorial Health Institute, Warsaw Poland Baltic Club 13-14.09.2013 Distinction Between Parenteral Nutrition

More information

What can we learn from the clinical studies in infants (on thickeners)?

What can we learn from the clinical studies in infants (on thickeners)? What can we learn from the clinical studies in infants (on thickeners)? Dominique Turck Member of the FAF WG Re-evaluation of FA in foods for infants below 16 weeks of age FA Stakeholders Workshop 30 November

More information

The Case Begins. The case continued. Necrotizing Enterocolitis

The Case Begins. The case continued. Necrotizing Enterocolitis Bugs, Drugs and Things that go Bump in the Night From ghoulies to ghosties and long leggety beasties & things that go bump in the night, good lord deliver us Old Cornish Prayer Caring for premature infant

More information

Pediatric PSC A children s tale

Pediatric PSC A children s tale Pediatric PSC A children s tale September 8 th PSC Partners seeking a cure Tamir Miloh Assistant Professor Pediatric Hepatology Mount Sinai Hospital, NY Incidence Primary Sclerosing Cholangitis (PSC) ;

More information

List of Topics and Modules (2012)

List of Topics and Modules (2012) List of Topics and Modules (202) Code Title Credits for Live course Topic 0 Introduction to Clinical Nutrition EDU T0 M 0. Introduction to clinical nutrition support Topic Metabolism of Metabolism of Macronutrients,

More information

ARTIFICIAL INTELLIGENCE FOR PREDICTION OF SEPSIS IN VERY LOW BIRTH WEIGHT INFANTS

ARTIFICIAL INTELLIGENCE FOR PREDICTION OF SEPSIS IN VERY LOW BIRTH WEIGHT INFANTS ARTIFICIAL INTELLIGENCE FOR PREDICTION OF SEPSIS IN VERY LOW BIRTH WEIGHT INFANTS Markus Leskinen MD PhD, Neonatologist Children s Hospital, University of Helsinki and Helsinki University Hospital The

More information

Infant Nutrition & Growth to Optimize Outcome Fauzia Shakeel, MD

Infant Nutrition & Growth to Optimize Outcome Fauzia Shakeel, MD Infant Nutrition & Growth to Optimize Outcome Fauzia Shakeel, MD Neonatologist All Children s Hospital / Johns Hopkins Medicine Affiliate Assistant Professor, University of South Florida September 2014

More information

PBC features and management in the era of UDCA and Budesonide

PBC features and management in the era of UDCA and Budesonide PBC features and management in the era of UDCA and Budesonide Raoul Poupon, MD Université P&M Curie, AP-Hôpitaux de Paris, Inserm, Paris, France The changing pattern of PBC Over the last 2 decades: More

More information

Lipids in TPN: Ready for Prime Time? Dr Jonathan Tan Senior Consultant Anaesthesiology and Intensive Care Tan Tock Seng Hospital, Singapore

Lipids in TPN: Ready for Prime Time? Dr Jonathan Tan Senior Consultant Anaesthesiology and Intensive Care Tan Tock Seng Hospital, Singapore Lipids in TPN: Ready for Prime Time? Dr Jonathan Tan Senior Consultant Anaesthesiology and Intensive Care Tan Tock Seng Hospital, Singapore Disclosures Travel and speakers honourarium from Abbott, Baxter,

More information

Parenteral Micronutrient Recommendations and Laboratory Monitoring for Infants on Long Term Parenteral Nutrition (PN)

Parenteral Micronutrient Recommendations and Laboratory Monitoring for Infants on Long Term Parenteral Nutrition (PN) Parenteral Micronutrient Recommendations and Laboratory Monitoring for nfants on Long Term Parenteral Nutrition (PN) Dosage Micronutrient Preterm Term Trace Elements (mcg/kg/day) (mcg/kg/day) 1 Chromium

More information

BILIARY ATRESIA. What is biliary atresia?

BILIARY ATRESIA. What is biliary atresia? The Childhood Liver Disease Research Network strives to provide information and support to individuals and families affected by liver disease through its many research programs. BILIARY ATRESIA What is

More information

Nutritional intervention in hospitalised paediatric patients. Dr Y.K.Amdekar

Nutritional intervention in hospitalised paediatric patients. Dr Y.K.Amdekar Nutritional intervention in hospitalised paediatric patients Dr Y.K.Amdekar Back to basics Suboptimal nutrient intake is always dangerous in health and more so in disease to feed or not to feed is it a

More information

ESPEN Congress Florence 2008

ESPEN Congress Florence 2008 ESPEN Congress Florence 2008 PN Guidelines presentation PN Guidelines in pancreas diseases L. Gianotti (Italy) ESPEN Guidelines on Parenteral Nutrition: Pancreas L.Gianotti, R.Meier, D.N.Lobo, C.Bassi,

More information

Nutritional Support in Paediatric Patients (1) Topic 4

Nutritional Support in Paediatric Patients (1) Topic 4 Nutritional Support in Paediatric Patients (1) Topic 4 Module 4.3 Nutrition Treatment in Children with Intestinal Failure with a Special Emphasis on Short Bowel Syndrome Learning Objectives Prof. Sanja

More information

Nutrition Management in GI Diseases

Nutrition Management in GI Diseases Nutrition Management in GI Diseases Aryono Hendarto MD Nutrition & Metabolic Diseases Division Department of Child Health Cipto Mangunkusumo Hospital University of Indonesia 1 Patient s Care 1. Drugs 2.

More information

WHEN To Initiate Parenteral Nutrition A Frequent Question With New Answers

WHEN To Initiate Parenteral Nutrition A Frequent Question With New Answers WHEN To Initiate Parenteral Nutrition A Frequent Question With New Answers Ainsley Malone, MS, RD, LD, CNSC, FAND, FASPEN Dubai International Nutrition Conference 2018 Disclosures No commercial relationship

More information

SOCIETAL PAPER. What Is Known

SOCIETAL PAPER. What Is Known SOCIETAL PAPER ESPGHAN Committee on Nutrition Position Paper. Intravenous Lipid Emulsions and Risk of Hepatotoxicity in Infants and Children: a Systematic Review and Meta-analysis Iva Hojsak, y Virginie

More information

Neonatal Parenteral Nutrition Guideline Dr M Hogan, Maire Cullen ANNP, Una Toland Ward Manager, Sandra Kilpatrick Neonatal Pharmacist

Neonatal Parenteral Nutrition Guideline Dr M Hogan, Maire Cullen ANNP, Una Toland Ward Manager, Sandra Kilpatrick Neonatal Pharmacist CLINICAL GUIDELINES ID TAG Title: Author: Designation: Speciality / Division: Directorate: Neonatal Parenteral Nutrition Guideline Dr M Hogan, Maire Cullen ANNP, Una Toland Ward Manager, Sandra Kilpatrick

More information

GUIDELINE FOR THE MANAGEMENT OF PROLONGED JAUNDICE IN BABIES. All babies admitted to hospital with prolonged jaundice

GUIDELINE FOR THE MANAGEMENT OF PROLONGED JAUNDICE IN BABIES. All babies admitted to hospital with prolonged jaundice GUIDELINE FOR THE MANAGEMENT OF PROLONGED JAUNDICE IN BABIES Reference No: Prolonged Jaundice Version No: 1 Applicable to All babies admitted to hospital with prolonged jaundice Classification of document:

More information

The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 19 October 2011

The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 19 October 2011 The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 19 October 2011 PEDIAVEN AP-HP G15, solution for infusion 1000 ml of solution in two chamber bag, B/4 (CIP code: 419

More information

Home Parenteral Nutrition (HPN) Sara Bonnes, M.D., M.S. General Internal Medicine Home Parenteral Nutrition Program Mayo Clinic, Rochester, MN

Home Parenteral Nutrition (HPN) Sara Bonnes, M.D., M.S. General Internal Medicine Home Parenteral Nutrition Program Mayo Clinic, Rochester, MN Home Parenteral Nutrition (HPN) Sara Bonnes, M.D., M.S. General Internal Medicine Home Parenteral Nutrition Program Mayo Clinic, Rochester, MN Objectives At the end of this presentation you will be able

More information

Individual Study Table Referring to Part of the Dossier. Use only) Name of Finished Product:

Individual Study Table Referring to Part of the Dossier. Use only) Name of Finished Product: SYNOPSIS Fresenius Title of the study: A double-blind, randomized study comparing the safety and torelance of SMOFlipid 20% and Intralipid 20% in long-term treatment with parenteral nutrition Coordinating

More information

NUTRITION SUPPORT TEAM. Consensus guideline for best practice in intestinal failure in paediatrics. John Puntis

NUTRITION SUPPORT TEAM. Consensus guideline for best practice in intestinal failure in paediatrics. John Puntis NUTRITION SUPPORT TEAM Consensus guideline for best practice in intestinal failure in paediatrics. John Puntis Nutritional Support Team What is a Nutritional Support Team? nutrition is a multidisciplinary

More information

Morabito A UK. -Royal Manchester Children s Hospital (PABRRU) -Intestinal Failure Unit Salford Royal Hospital

Morabito A UK. -Royal Manchester Children s Hospital (PABRRU) -Intestinal Failure Unit Salford Royal Hospital NON-TRANSPLANT SURGERY IMPROVES OUTCOME IN SHORT BOWEL PATIENTS Morabito A UK -Royal Manchester Children s Hospital (PABRRU) -Intestinal Failure Unit Salford Royal Hospital antonino.morabito@cmft.nhs.uk

More information

ESPEN LLL Programme in Clinical Nutrition and Metabolism. List of Topics and Modules 2014

ESPEN LLL Programme in Clinical Nutrition and Metabolism. List of Topics and Modules 2014 ESPEN LLL Programme in Clinical Nutrition and Metabolism List of Topics and Modules 204 Code Title Credits for Live course Credits for on-line course Credits for Grading Quiz Topic 0 Introduction in Nutrition

More information

EVALUATION OF ABNORMAL LIVER TESTS

EVALUATION OF ABNORMAL LIVER TESTS EVALUATION OF ABNORMAL LIVER TESTS MIA MANABAT DO PGY6 MOA 119 TH ANNUAL SPRING SCIENTIFIC CONVENTION MAY 19, 2018 EVALUATION OF ABNORMAL LIVER TESTS Review of liver enzymes vs liver function tests Clinical

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Note: Page numbers of article titles are in boldface type. A Abdominal pain, enteral therapy in acute pancreatitis and, 812 Abscess(es), pancreatic, nutritional support for, 814 815 Acute Physiology and

More information

TOTAL PARENTERAL NUTRITION

TOTAL PARENTERAL NUTRITION TOTAL PARENTERAL NUTRITION Indication See algorithm. Timing Start TPN as indicated on algorithm 1. There is no need to build up TPN volume. The volume of TPN (including lipids) should equate to the total

More information

Preterm Dietary Supplements

Preterm Dietary Supplements Preterm Dietary Supplements Dr Umesh Vaidya IAP Neocon, Mumbai 2015 Preterm VLBW Nutrition : Ideal practice Minimal enteral feeds (10 ml / kg / day) Human breast milk Feed advancement @ 20 ml / kg / day

More information

CHILDREN: NUTRITIONALS Prescription Required Provided by the Wisconsin WIC Program to Children (1 through 4 Years of Age)

CHILDREN: NUTRITIONALS Prescription Required Provided by the Wisconsin WIC Program to Children (1 through 4 Years of Age) P-40077C (03/2016) CHILDREN: NUTRITIONALS Prescription Required Provided by the Wisconsin WIC Program to Children (1 through 4 Years of Age) A Prescription, for treatment of a diagnosed medical condition,

More information

Fluid & Electrolyte Balances in Term & Preterm Infants. Carolyn Abitbol, M.D. University of Miami/ Holtz Children s Hospital

Fluid & Electrolyte Balances in Term & Preterm Infants. Carolyn Abitbol, M.D. University of Miami/ Holtz Children s Hospital Fluid & Electrolyte Balances in Term & Preterm Infants Carolyn Abitbol, M.D. University of Miami/ Holtz Children s Hospital Objectives Review maintenance fluid & electrolyte requirements in neonates Discuss

More information

Providing Optimal Nutritional Support on the ICU common problems and practical solutions. Pete Turner Specialist Nutritional Support Dietitian

Providing Optimal Nutritional Support on the ICU common problems and practical solutions. Pete Turner Specialist Nutritional Support Dietitian Providing Optimal Nutritional Support on the ICU common problems and practical solutions Pete Turner Specialist Nutritional Support Dietitian ICU Nutritional Support ACCEPT study showed improved ICU survival

More information

Melinda Elliott, MD Senior Director, Clinical Education and Professional Development, Prolacta Bioscience Neonatologist, Pediatrix Medical Group of

Melinda Elliott, MD Senior Director, Clinical Education and Professional Development, Prolacta Bioscience Neonatologist, Pediatrix Medical Group of Melinda Elliott, MD Senior Director, Clinical Education and Professional Development, Prolacta Bioscience Neonatologist, Pediatrix Medical Group of Maryland Breast Milk is for Babies, Cows Milk is for

More information

BILIARY ATRESIA PROTOCOL FOR DIAGNOSIS AND MANAGEMENT

BILIARY ATRESIA PROTOCOL FOR DIAGNOSIS AND MANAGEMENT Diagnosis Management Pre & Post Operative Cholangiogram & Kasai Nutritional Management Including Fat Soluble Vitamin Supplements Follow - Up Patients Following Kasai Portoenterostomy Immunisations for

More information

The Potential For Microbiome Modification In Critical Illness. Deborah Cook

The Potential For Microbiome Modification In Critical Illness. Deborah Cook The Potential For Microbiome Modification In Critical Illness Deborah Cook To review Objectives The microbiome & concepts about its modification during critical illness Interventions Predisposition to

More information

Parenteral Nutrition Recommendations for Pediatric Patients

Parenteral Nutrition Recommendations for Pediatric Patients Fluid Dextrose Amino acid Lipid Parenteral Nutrition Recommendations for Pediatric Patients (Calculated for normal organ function and normal caloric requirements) PN orders are due by 11 AM daily Newborn

More information

Appendix 9B. Diagnosis and Management of Infants with Suspected Cow s Milk Protein Allergy.

Appendix 9B. Diagnosis and Management of Infants with Suspected Cow s Milk Protein Allergy. Appendix 9B Diagnosis and Management of Infants with Suspected Cow s Milk Protein Allergy. A guide for healthcare professionals working in primary care. This document aims to provide health professionals

More information

ACG Clinical Guideline: Primary Sclerosing Cholangitis

ACG Clinical Guideline: Primary Sclerosing Cholangitis ACG Clinical Guideline: Primary Sclerosing Cholangitis Keith D. Lindor, MD, FACG 1, Kris V. Kowdley, MD, FACG 2, and M. Edwyn Harrison, MD 3 1 College of Health Solutions, Arizona State University, Phoenix,

More information