THE NEW GENERATION ACIDIFIER IN BROILER DIETS

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1 THE NEW GENERATION ACIDIFIER IN BROILER DIETS Animals are able to produce Butyric acid, Phytogenics are extracts from plants. Mother Nature obviously had a good reason for this. In combination with the Mycotoxin binder we achieved the optimal synergy.

2 THE NEW GENERATION ACIDIFIER IN BROILER DIE TS THE VALUE OF ORGANIC ACIDS IN BROILER DIET S MONOBUTYRIN, A NEW MOLECULE 1) It fuels the gut mucosa cells by providing extra energy in the gut and consequently plays an important role in the proliferation and differentiation of the epithelial cells INTRODUCTION Successful feed formulations must both promote the growth of the animal and discourage the growth of pathogenic bacteria in the gastrointestinal tract. Feeding for health as well as growth is certainly a major criterion in the design and formulation of poultry feeds. Organic acids are used in feeds for their various beneficial effects in the gut: feed preservation to control microbial growth, reduction of the feed buffer capacity, inhibition of pathogenic bacteria and improvement of nutrient digestibility. These effects will result in improved growth performance and improved profitability of poultry production. Due to their different chemical structures, different acids have different properties. The response to diet acidification may be affected by type of acid, inclusion level, diet composition and dietary buffering capacity. The key basic principle on the mode of action of organic acids on bacteria is that non-dissociated (non-ionized) organic acids can penetrate the bacteria cell wall and disrupt the normal physiology of certain types of bacteria. We call these bacteria ph sensitive meaning that they cannot tolerate a wide internal and external ph gradient. Among those bacteria we have E.Coli, Salmonella spp, C.perfringens. It has been well demonstrated that the state of organic acids (non-dissociated or dissociated) is extremely important to define their capacity to inhibit the growth of bacteria. As a general rule, we need more than ten to twenty times the level of dissociated acids to reach the same inhibition of bacteria, compared to non-dissociated acids. Amongst the wide range of organic acids used in animal nutrition, butyric acid takes a unique position. Due to mycotoxins in grains, technical results and litter quality in broiler flocks can be disappointing. By combining Mycotoxin-binder in the new generation additive these effects can be counteracted. Monobutyrin, the monoglyceride of butyric acid, is a polar molecule. Due to the fact that most pathogens (like E-Coli, Salmonella, Clostridium Perfringens) have a hydrophilic membrane, Monobutyrin can enter these pathogens and destroy the cell. Monoglycerides from organic acids are up to 30 times more effective against bacteria then its original organic acid. Another advantage of monobutyrin is its water solubility which makes it also active in Increase sodium absorption the crop and the gizzard. Di- and triglycerides of butyric acid are non-polar and have a negative influence on the palatability. They have no destroying effect on bacteria in the crop and gizzard. Di- and tri- glycerides, contained by Monobutyrin, have the following specific and unique functions: Nutrition of coloncyte (butyrate) Energy salvage Butyrate and other SCFAs Decrease blood cholesterol (propionate) Immunomodulation Fig. 1 Flowchart summarizing the different mode of actions of butyrate in the gut 2) It stimulates the development of a favourable intestinal flora (e.g. Lactobacilli) 3) It reduces the colonization and invasiveness of Salmonella in the gut (caeca) 4) It reduces the risks for incidence such as necrotic enteritis (Clostridium perfringens) and Colibacillosis. 5) It enhances the barrier function of the intestinal epithelium since butyrate up-regulates the expression of tight junction proteins (= glue joining the epithelial cells together) Increase mucosal blood flow Regulate cell proliferation Effect on cell differentation 2 3

3 THE NEW GENERATION ACIDIFIER IN BROILER DIE TS PHYTOGENE COMPLEX, A NATURAL DIGESTIBILITY ENHANCER The phytogenic complex is a mixture of fine grinded natural herbs enriched with extracts and essential oils. The phytogenic complex is defined as a flavour/aroma for animal feed and is approved in the EU and US. The phytogenic complex is developed to: stimulate the feed intake. improve the digestion of nutrients. stimulate the production of animal own enzymes. increase the health status of the animals (Reduction of mortality and morbidity) Liver, Kidneys: optimised function for detoxfication Gall bladder: higher production of conjugated bile acids MODE OF ACTION IN Proventriculus: higher production of HCI and pepsin Whole gut: stabilisation of physiological micro flora Plant parts, plant extracts and essential oils. Plant parts and plant extracts, are the fundamentals for the phytogenic complex. The most active substances in the complex for poultry are: Foeniculum vulgarae (Fennel), Melissa officinalis L.(Melissa balm), Mentha arvensis L. (Peppermint), Pimpinella anisum L. (Anise), Quercus cortex (Oak), Syzygium aromaticum L. (Clove),Thymus vulgaris L. (Thyme) Plant parts and extracts contain a high number of active components like saponins and tannins. Saponins stimulate the activities of all organs and improve the effectiveness of medication. The content of the different active substances is standardized to aim for constant quality since the quantities of active compounds can vary in the basic ingredients.. Tannin substances (e.g. oak bark) have an antibacterial effect and show positive effects against wet litter Essential oils (e.g. peppermint oil), produce a very characteristic smell and taste and evaporate at room temperature. The smell and taste influence the stomach and intestine, the ingredients stimulate the saliva production. Other ingredients of essential oils have an influence on the gall bladder. In volatile form these essential oils ease their respiration and have an antibacterial and mould inhibiting function. In Holland a trial has been conducted over 6 rounds with 100,000 animals per cycle. In table 1 the results are presented. Pancreas: higher enzyme secretion (e.g. amylase, maltase, lipases) Small intestine : optimisation of nutrient absorption control average + Phytogene complex average effect of complex Based on research the most important effects are: Improvement of taste (increase of feed intake) Improvement of the enzyme secretion resulting in better weight gain and feed conversion. Stabilisation of heath status and stimulation of the immune system of the animals Prevention of wet litter (due to products with tannins) Fig. 2 Mode of action of phytogenics in poultry Number broilers total Animals started per round Growing days body weight/animal [g] Daily gain [g] Mortality [%] Broilers/m2 Feed intake/animal [g] FCR netto [kg/kg] FCR corrected 1500 g [kg/kg] EPEF Manure [kg/animal] Medication costs/round [ ] 593,600 98, \ ,616 98, , Table 1 5

4 FR A B PM B R O I L E R B UT YRIC / P HY TOGENIC / M YCOTOXIN-BINDER THE NE W GENER ATION ACIDIFIER IN BR OILER DIE TS MYCOTOXIN-BINDER, TO COUNTERACT THE EFFECTS OF MYCOTOXINS CONCLUSION Mycotoxins are toxic secondary metabolites produced by molds, mostly belonging to the three genera Aspergillus, Penicillium and Fusarium. These fungal toxins are chemically diverse accounting for their different biological effects. There are hundreds of mycotoxins known, but few have been extensively researched. The most notorious and extensively investigated mycotoxins are aflatoxin B1 (AFB1), ochratoxin A (OTA), fumonisin B1 (FB1), zearalenon (ZEN), deoxynivalenol (DON), and T2 toxin. The combination of Monobutyrin, Phytogenic complex and Mycotoxin-binder has a great synergy. The effect of the phytogenic complex to enhance the body s own enzyme production will improve the digestibility, the feed intake, the growth and reduce the feed conversion. By stimulating the immune system of the animal, the mortality and morbidity of the flock will go down. By killing the pathogenic bacteria in the crop and gizzard, they will not enter the intestine. When there will be an attack by pathogens from the caeca to the distal part of the intestine, the monobutyrin is still able to kill these pathogens. Mycotoxinbinders will prevent damage to the gut mucosa, liver and kidneys leading to a better litter quality. These combinations will result in healthier animals with better technical and financial results of broiler flocks. Fungi Mycotoxins Aspergillus flavus, A. parasiticus, A. nomius Aflatoxins B1, B2, G1, G2 Penicillium verrucosum, Aspergillus clavatus Ochratoxin A Fusarium sporotrichioides, F. graminearum, Trichothecenes (Deoxynivalenol) Fusarium moniliforme, F. proliferatum Fumonisins B1, B2, B3 Fusarium graminearum, F. culmorum, F. crookwellense Zearalenone Table 2. Fungi and their associated mycotoxins Fungi on crops produce them in the field, during handling, and during storage. A practical definition of a mycotoxin is a fungal metabolite that causes an undesirable effect when animals or humans are exposed. Mycotoxicoses are diseases caused by exposure to foods or feeds contaminated with mycotoxins. Depending on their precise nature, these mycotoxins exhibit a variety of biological effects in animals such as: liver and kidney toxicity, central nervous system abnormalities, reproductive disorders, immune suppression and others. The toxic effects of Fusarium mycotoxins in animals and poultry include reduced growth, feed refusal and vomiting, immunosuppression, gastrointestinal lesions, and neurological and reproductive disorders. Deoxynivalenol (DON), a Trichothecene mycotoxin, causes suppression of feed intake in susceptible species. 6 7

5 the versatile acidifier DOSAGE: POULTRY: - Feed 0.1% THE PRODUCT IS: - GRAS (Generally Recommended As Safe) - non-corrosive - safe in transport - safe in handling - safe in processing SILO ADDITIVES Srl is a joint-venture of Wenemco BV and SILO Srl Via San Bartolo a Cintoia, 104a Firenze, Italy P: +31 (0) , F: +31 (0) , E: info@wenemco.com, info@silosrl.com W:

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