Nuvisol Numisol Water-soluble supplements

Transcription

1 Nuvisol Numisol Watersoluble supplements Solving solutions

2 nuvisol numisol solving solutions 2 nnproduct range Table 1: Application Nuvisol range watersoluble vitamins Administration Species Dosage Packaging Nuvisol Hatch To improve hatchling quality, laying performance and fertility To overcome stress or disease Layers Breeders Hatchlings 0.5L / 1000 L drinking water Bottle of 500 ml Starters Pullets Broilers Layers Breeders 100 mg / kg feed Nuvisol C99 To build up resistance against infections and stress To improve functioning of collagen tissue, e.g. cartilage, bones and skin To improve production Calf milk replacer Fattening cattle Dairy cows Piglet (720 kg) Pig (2040 kg) Fattening pig Sow mg / kg feed mg daily / animal 150 mg / kg feed Cartons of 25 kg Sealed plastic pots of 1 kg or g / 1000 L drinking water Nuvisol Tonic To enhance energy metabolism To support growth To overcome stress conditions To develop smooth and glossy plumage Poultry 750ml 1L / 1000 L drinking water Bottle of 1L 5L plastic container Nuvisol Heat To maintain performance in case of heat stress Poultry 250g / 1000 L drinking water Plastic pots of 1kg Bags of 5kg Bags of 25kg Table 2: Numisol Range Watersoluble minerals Application Administration Packaging Numisol Foscal Used during fast growth To decrease the occurrence of fragile bones Poultry 1L/1000 L drinking water 5L or 25L plastic container

3 nuvisol numisol solving solutions 3 Table 3: Active substances VITAMINS AND DERIVATES Nuvisol Hatch Nuvisol C99 Nuvisol Tonic Nuvisol Heat Numisol Foscal Betaine Biotin Choline Inositol LCarnitine Vitamin B1 Vitamin B2 Vitamin B3 Vitamin B6 Vitamin B9 Vtamin B12 Vitamin C Vitamin E Vitamin PP LLysine AMINO ACIDS AND DERIVATES Nuvisol Hatch Nuvisol C99 Nuvisol Tonic Nuvisol Heat Numisol Foscal MINERALS Nuvisol Hatch Nuvisol C99 Nuvisol Tonic Nuvisol Heat Numisol Foscal Calcium Chlorine Copper Iron Magnesium Manganese Phosphorus Potassium Sodium Zinc

4 nuvisol numisol solving solutions 4 nnactive substances of Nuvisol and Numisol products Vitamin Bcomplex Vitamins of the Bcomplex are part of many (co)enzymes and therefore they play an important role in fat, protein and carbohydrate metabolism. Besides this, they are also essential for optimal functioning of the central nervous system and important for haematopoiesis. Deficiency symptoms include: loss of skin pigment loss of feathers encrustation on the beak and around the eyes formation of ulcers in the GItract fatty liver diarrhoea weight loss reduced egg yield unsatifying incubation results higher stress sensitivity Niacin Niacin is part of hydrogen transferring coenzymes such as NAD and NADP, which are involved in numerous metabolic reactions for the synthesis and breakdown of carbohydrates, fats and proteins. Deficiency symptoms include: depression of growth feather development disorders poor egg yield perosis, e.g. leg damage Biotin Biotin is involved in many biochemical reactions, e.g. carboxylation. During an immune response, biotin activates lysosyme. Deficiency symptoms include: poor plumage swelling of eyelids dermatitis, particularly on toes, legs and in the corners of the beak perosis low hatching rates fatty liver syndrome

5 nuvisol numisol solving solutions 5 LCarnitine Figure 1: energy utilisation from fats MITOCHONDRION CYTOSOL Lcarnitine increases the energy utilisation from fats (figure 1). CoA AcylCarnitine Fatty acid CoA AcylCoA AcylCarnitine Long chain fatty acids cannot migrate through the membrane of mitochondria. Lcarnitine transports them into the mitochondria, where the fatty acids are oxidized and transformed into enery (ATP). AcylCoA Carnitine Oxidationβ AcetylCoA Krebs cycle Carnitine CO₂ + ATP Lcarnitine buffers the CoA / AcetylCoA ratio. (figure 2) Figure 2: Buffering capacity of Lcarnitine MITOCHONDRION Carnitine CoA AcetylCoA Krebs cycle AcetylCarnitine Carnitine Pyruvate Lactate AcetylCarnitine Carnitine Glucose CYTOSOL CoA AcetylCoA The Krebs cycle usually becomes overcharged when energy demand is high. This results in an accumulation of acetylcoa in the mitochondria. Symptoms associated with this are cramps, cell damage, decreased performance and higher mortality. Lcarnitine is required to restore the balance between free CoA and AcetylCoA. Lcarnitine functions by transporting acetylcarnitine into the cytosol which results in an increased concentration of free CoA in the mitochondria. Energy is temporarily stored as acetylcarnitine in the cytosol. When the energy demand returns to normal, sufficient free CoA in the cytosol results in recovery of free Lcarnitine and recovery of stored energy. AcetylCoA is again available for the Krebs cycle. Lcarnitine plays an important role in detoxification. In case of long term stress, accumulated acetylcarnitine in the cytosol can be transported into the blood and secreted via urine. Lcarnitine also helps to reduce the occurrence of fatty liver.

6 nuvisol numisol solving solutions 6 Choline Choline is an essential constituent of phospholipids such as phosphatidylcholine, sphyngomyeline and phospholipids that maintain the integrity of cell membranes and of lecithine, which is a component of egg yolk. Furthermore, choline is essential for the fat metabolism in the liver where it is part of lipoproteins that transport lipids between tissues and organs and as a precursor for acetyl choline synthesis. For these functions, choline can not be replaced by betaine or methionine. Due to their similar structure, choline can function as a methyldonor, reducing consumption of betaine and methionine. Deficiency symptoms include: slow growth rates, caused by fatty liver, that result from a lack of lipoproteinassembly Kidney and bone dysfunctions Figure 3: Methyl donors Feed Intake Betaine Choline Betaine CH₃ Protein synthesis Methionine Homocysteine Sadenosylmethionine Sadenosyl homocysteine Betaine In hot climate conditions, chickens suffer from heat stress, which can result in panting. Panting indicates the chicken is trying to get rid of the heat, which provokes an elimination of essential nutrients such as water. Betaine has osmolytic properties and therefore helps to prevent dehydration. It can also replace methionine as a methyldonor in numerous metabolic reactions to lower feed costs. CH₃methylation reaction

7 nuvisol numisol solving solutions 7 Vitamin C During heat stress, synthesis and intake of vitamin C is reduced which results in a partial depletion of the body stores. Supplementation of vitamin C is required : to help control the body temperature for conversion of calcitriol from vitamin D to improve egg shell quality 3 to enhance resistance against infections and diseases Electrolytes Panting provokes an elimination of water, but it also increases emission of CO 2. This affects the equilibrium between HCO 3 and CO 2 in the blood and results in a higher bloodph which is also referred to as respiratory alkalosis. To compensate for this ph increment, excretion of HCO 3 and potassium in the kidneys increases and supplementation of electrolytes becomes necessary to restore the electrolyte balance and to lower the ph to normal level. Llysine Metabolic component HCO 3 Blood ph = pk a + log CO 2 Panting Metabolic component HCO 3 ph = pk a + log CO 2 At temperatures of 27 C and higher, the energy requirement for maintenance increases and reduced feed intake of broilers is responsible for a reduced growth rate. Therefore, offering diets with a higher energy content can partially compensate for this growth depression. In semitropical and tropical countries, nutritionists usually boost the energy level of these diets by adding fat, because fat has a lower heat increment than carbohydrates or proteins. It is recommended to formulate these diets with slightly lower protein levels and to utilize synthetic amino acids, especially lysine. Supplementing lysine through the drinking water appears necessary to compensate for reduced feed intake and to improve feed efficiency. ph Panting Renal compensation HCO 3 = pk a + log CO 2 Panting

8 n u v i s o l n u m i s o l w a t e r soluble supplements 8 Nuvisol & Numisol Watersoluble supplements Phosphorous and calcium Phosphoros and calcium are essential in bone mineralization. The ratio of Ca:P available is even more important than the absolute level of each of them. Supplementing calcium and phosphorous is necessary to correct the mineral imbalance in rations, resulting in a decreased occurrence of fragile and soft bones. Imbalances result in: poor growth weakness bone deformities Minerals Mineral deficiencies can cause several health problems and in some cases even increase mortality. To prevent mineral deficiencies or when deficiency symptoms are noticeable, a balanced combination of minerals should be supplied. Nutrex NV Achterstenhoek Lille Belgium Tel info@nutrex.be NXNUVNUM E V1