* * * * * liver kidney ileum. Supplementary Fig.S1

Size: px
Start display at page:

Download "* * * * * liver kidney ileum. Supplementary Fig.S1"

Transcription

1 Supplementry Fig.S1 liver kidney ileum Fig.S1. Orlly delivered Fexrmine is intestinlly-restricted Mice received vehicle or Fexrmine (100mg/kg) vi per os (PO) or intrperitonel (IP) injection for 5 dys (n=3/group). () Expression of the FXR trget gene SHP fter PO or IP injection in selected tissues. () Expression of the FXR trget genes fter IP Fexrmine tretment in selected tissues. Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

2 Supplementry Fig.S2 d c e Fig.S2. Fexrmine hs no effect in norml mice () Body weight, () cron dioxide production, (c) oxygen consumption, (d) glucose tolernce test, nd (e) core temperture of chow-fed mice treted with vehicle or fexrmine (100mg/kg) vi PO for 5 weeks. n=4/group. Dt represent the men ± SD. Sttisticl nlysis s performed with the Student s t test. p<0.05, p<0.01

3 Supplementry Fig.S3 c Fig.S3. Fexrmine dose dependently improves glucose homeostsis. () Fsting glucose levels in 14 week HFD fed mice treted with vehicle or fexrmine (100mg/kg/dy os for 5 week). () Body weights of 14 week HFD fed mice treted with vehicle or fexrmine (10, 50, or 100mg/kg/dy per os) for 5 weeks with HFD. (c) Glucose tolernce test performed on HFD fed mice treted with vehicle or fexrmine (10, 50, or 100mg/kg/dy per os) for 5 weeks with HFD. n=6/group Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

4 Supplementry Fig.S4 ileum colon Vehicle Fexrmine Fig.S4. Fexrmine tretment improves gut helth Histologicl nlysis of ileum nd colon of 14 week HFD fed mice fter vehicle or Fexrmine tretment (100mg/kg/dy os for 5 week with HFD). Scle rs in ileum: 50 μm, scle rs in colon: 100 μm.

5 Supplementry Fig.S5 c d e f g h i Fig.S5. FXR is required for Fexrmine s effects () glucose tolernce test, () insulin sensitivity test, (c) Body weights (d) oxygen consumption, (e) cron dioxide production, (f) core temperture, (g) rown dipose tissue gene expression, (h) liver gene expression, nd (i) FXR trget gene expressions in ileum of 14 week HFD fed FXR-null mice treted with vehicle or fexrmine (100mg/kg) for 5 week with HFD. n=4/group. Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

6 Supplementry Fig.S6 Fig.S6. Fexrmine does not ffect the respirtory exchnge rtio. Respirtory exchnge rtios in 14 week HFD fed mice treted with vehicle or fexrmine (100mg/kg/dy os) for 5 week with HFD.

7 Supplementry Fig.S7 pp38 P38 RlA Vehicle Fex(50mg/kg) Fex (100mg/kg) c KEGG pthwy Term Oxidtive phosphoryltion Chemokine signling pthwy Cytokine-cytokine receptor interction Biosynthesis of unsturted ftty cids PPAR signling pthwy p-vlue 8.12E E E E E-03 OXPHOS gene chnges normlized expression d e f iwat gwat BAT Fig.S7. Fexrmine enhnces rown dipose tissue OXPHOS 14 week HFD fed mice were treted with vehicle or fexrmine (100mg/kg/dy os for 5 week on HFD). () Totl nd phosphorylted P38 protein in BAT. () Hetmp of expression chnges OXPHOS genes. (c) KEGG pthwy nlysis of trnscriptionl chnges in BAT. (d) Hetmp of chemokine nd cytokine signling pthwy in BAT. (e) PKA ctivity in BAT. (f) Serum lctte level. Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

8 Supplementry Fig.S8 ileum KEGG pthwy Term PPAR signling pthwy Adipocytokine signling pthwy Retinol metolism Drug metolism Archidonic cid metolism p-vlue 1.86E E E E E-03 colon KEGG pthwy Term PPAR signling pthwy Adipocytokine signling pthwy Retinol metolism p-vlue 3.52E E E-02 Fig.S8. Fexrmine induces multiple metolic pthwys Mice fed HFD for 14 weeks were mintined on HFD nd treted with vehicle or fexrmine (100mg/kg/dy os for 5 week). () Kegg pthwy nlysis of trnscriptionl chnges induced in ileum nd colon, s determined y RNA-Seq. () Heptic Cyp71 levels determined y ELISA. Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

9 Supplementry Fig.S9 Fig.S9. Fexrmine fils to ctivte TGR5 HEK293 cells were trnsfected with expression vectors for camp-response element luciferse, β-glctosidse nd humn TGR5. 24 hr fter trnsfection, cells were treted with Fexrmine or INT-777 t indicted concentrtion for 5 hr. Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

10 Supplementry Fig.S10 % of camp production L A L EC50 300nM RO EC50 70nM c Compound concentrtion, log [M] d e f n.s Fig.S10 Systemic TGR5 ctivtion is required to ffect glucose homeostsis HFD-fed mice were treted with vehicle, the intestinllyrestricted TGR5 lignd L (, L755,100mg/kg EC50 300nM) or the systemic lignd RO (, RO,100mg/kg) vi per os for 14 dys. c, Plsm L755 concentrtion in portl nd til vein fter PO dministrtion. d, Body weight curve. e, Glucose tolernce test. f, Insulin secretion in vivo fter glucose injection. Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

11 Supplementry Fig.S11 ileum c d e BAT f g h i j liver soleus

12 Fig.S11. TGR5 is required for suset of Fexrmine e effects HFD-fed TGR5-null mice were treted with vehicle or fexrmine (100mg/kg os dily for 5 week with HFD, n=10). () Ilel FXR trget gene expressions () Serum BA levels (c) Fsting glucose level (left) nd Glucose tolernce test (right) (d) Core temperture (left), Oxygen consumption rte (middle), nd cron dioxide production (right) (e) Gene expressions in BAT (f) Body weight curve (left) nd Body composition y MRI (right) (g) Insulin Tolernce Test (h) Heptic gene expression (i) Heptic TG levels (j) Gene expressions in soleus. n=9/group. Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

13 Supplementry Fig.S12 Fig.S12. Fex tretment suppresses inflmmtion in dipose tissues. Mice fed HFD for 14 weeks were mintined on HFD nd treted with vehicle or fexrmine (50mg or 100mg/kg/dy os for 5 week). () Gondl white dipose tissue (gwat) ws sujected to protein expression nlysis y western lotting. () Expression of inflmmtory cytokines in BAT. Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

14 Supplementry Fig.S13 Fig.S13. Fexrmine enhnces OXPHOS in iwat Mice fed HFD for 14 weeks were mintined on HFD nd treted with vehicle or fexrmine (100mg/kg/dy os for 5 week). () Gene expressions nd () oxygen consumption rte of SVF from inguinl ft (iwat). Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

15 Supplementry Fig.S14 c clmp m g / k g / m i n IS-GDR Ve h Fex I n s u l i n ( n g / m L ) Ve h Fe x Bsl Clmped Fig.S14. Hyperinsulinemic-euglycemic clmps Mice fed HFD for 14 weeks were mintined on HFD nd treted with vehicle or fexrmine (100mg/kg/dy os for 3 week). Hevier mice (y 2~3 grm) were selected for fexrmine tretment in order to chieve equivlent treted ody weights for the clmp study. () Body weight curve. () Insulinstimulted GDR (IS-GDR). (c) Fsting insulin level. n=14/group. Dt represent the men ± SD. Sttisticl nlysis ws performed with the Student s t test. p<0.05, p<0.01

16 Supplementry Tle.S1 Bile cid composition (%) Vehicle Fexrmine CA TCA CDCA TCDCA LCA GLCA N.D DCA TDCA HDCA T-HDCA 0.99 N.D UDCA T-UDCA lph MCA 0.33 N.D et MCA 0.55 N.D T-et MCA omeg MCA Tle S1. Fexrmine lters the serum ile cid composition Mice fed HFD for 14 weeks were mintined on HFD nd treted with vehicle or fexrmine (100mg/kg/dy per os for 5 week). Serum ile cid composition ws determined y mss spectrometry. N.D not determined

Supplementary Figure S1

Supplementary Figure S1 Supplementry Figure S Tissue weights (g).... Liver Hert Brin Pncres Len mss (g) 8 6 -% +% 8 6 Len mss Len mss (g) (% ody weight) Len mss (% ody weight) c Tiilis nterior weight (g).6...... Qudriceps weight

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION X p -lu c ct ivi ty doi:.8/nture8 S CsA - THA + DAPI Merge FSK THA TUN Supplementry Figure : A. Ad-Xp luc ctivity in primry heptocytes exposed to FSK, THA, or TUN s indicted. Luciferse ctivity normlized

More information

Bile acid receptor FXR: metabolic regulator in the gut. Sungsoon Fang

Bile acid receptor FXR: metabolic regulator in the gut. Sungsoon Fang Bile acid receptor FXR: metabolic regulator in the gut Sungsoon Fang Nuclear hormone receptor 1905: Ernest Starling coined hormone 1929: Estrogen structure 1958: Estrogen receptor by Elwood Jensen 1985:

More information

2018 American Diabetes Association. Published online at

2018 American Diabetes Association. Published online at Supplementry Figure S1. Ft-1 mice exhibit reduced diposity when fed n HFHS diet. WT nd ft-1 mice were fed either control or n HFHS diet for 18 weeks. A: Representtive photogrphs for side-by-side comprison

More information

DOI: 10.1038/nc2331 PCre;Ros26R 12 h induction 48 h induction Vegfr3 i EC c d ib4 24 h induction VEGFR3 e Fold chnge 1.0 0.5 P < 0.05 Vegfr3 i EC Vegfr3 Figure S1 Cre ctivtion leds to genetic deletion

More information

*** *** *** *** T-cells T-ALL. T-cells T-ALL. T-cells T-ALL. T-cells T-ALL. T-cells T-ALL. Relative ATP content. Relative ATP content RLU RLU

*** *** *** *** T-cells T-ALL. T-cells T-ALL. T-cells T-ALL. T-cells T-ALL. T-cells T-ALL. Relative ATP content. Relative ATP content RLU RLU RLU Events 1 1 1 Luciferin (μm) T-cells T-ALL 1 1 Time (min) T-cells T-ALL 1 1 1 1 DCF-DA Reltive ATP content....1.1.. T-cells T-ALL RLU 1 1 T-cells T-ALL Luciferin (μm) 1 1 Time (min) c d Control e DCFH-DA

More information

Cyanidin-3-O-glucoside ameliorates lipid and glucose accumulation in C57BL/6J mice via activation of PPAR-α and AMPK

Cyanidin-3-O-glucoside ameliorates lipid and glucose accumulation in C57BL/6J mice via activation of PPAR-α and AMPK 3 rd Interntionl Conference nd Exhiition on Nutrition & Food Sciences Septemer 23-25, 214 Vlenci, Spin Cynidin-3-O-glucoside meliortes lipid nd glucose ccumultion in C57BL/6J mice vi ctivtion of PPAR-α

More information

Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons

Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons nd grdul increses in BDNF concentrtion elicit distinct signling nd functions in neurons Yunyun Ji,, Yun Lu, Feng Yng, Wnhu Shen, Tin Tze-Tsng Tng,, Linyin Feng, Shumin Dun, nd Bi Lu,.. - Grdul (normlized

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION doi:.3/nture93 d 5 Rttlesnke DRG (reds) Rttlesnke TG (reds) c 3 TRPV1 other TRPs 1 1 3 Non-pit snke TG (reds) SFig. 1 5 5 3 other TRPs TRPV1 1 1 3 Non-pit snke DRG (reds) 5 Antomy of the pit orgn nd comprison

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION SUPPLEMENTARY INFORMATION doi:10.1038/nture11225 Numer of OTUs sed on 3% distnce Numer of 16s rrna-sed V2-V4 tg sequences LF MF PUFA Supplementry Figure 1. High-ft diets decrese the richness nd diversity

More information

TNF-α (pg/ml) IL-6 (ng/ml)

TNF-α (pg/ml) IL-6 (ng/ml) Xio, et l., Supplementry Figure 1 IL-6 (ng/ml) TNF-α (pg/ml) 16 12 8 4 1,4 1,2 1, 8 6 4 2 med Cl / Pm3CSK4 zymosn curdln Poly (I:C) LPS flgelin MALP-2 imiquimod R848 CpG TNF-α (pg/ml) IL-6 (ng/ml) 2 1.6

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION doi:1.138/nture1794 BR EPFs BRI1? ERECTA TMM BSKs YDA PP2A BSU1 BIN2 pbzr1/2 BZR1/2 MKK4/5/7/9 MPK3/6 SPCH Cell growth Stomtl production Supplementry Figure 1. The model of BR nd stomtl signling pthwys.

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION SUPPLEMENTARY INFORMATION doi:.8/nture89 4 4 Ilr -/- Ilr -/- Ilr -/- Cspse- -/- As -/- Nlrp -/- Il8 -/- Ilr -/- Supplementl figure. Inresed severity of NASH in inflmmsome-defiient mie, ut not in Ilr-defiient

More information

AMPK maintains energy homeostasis and survival in cancer cells via. regulating p38/pgc-1α-mediated mitochondrial biogenesis

AMPK maintains energy homeostasis and survival in cancer cells via. regulating p38/pgc-1α-mediated mitochondrial biogenesis SUPPLEMENTARY INFORMATION AMPK mintins energy homeostsis nd survivl in cncer cells vi regulting p38/pgc-1α-medited mitochondril iogenesis Blkrishn Chue 1, Prmnnd Mlvi 1, Shivendr Vikrm Singh 1, Noshd Mohmmd

More information

The effect of dietary α-linolenic acid levels on regulation of omega-3 lipid synthesis in rat

The effect of dietary α-linolenic acid levels on regulation of omega-3 lipid synthesis in rat The effect of dietry α-linolenic cid levels on regultion of omeg-3 lipid synthesis in rt Wei-Chun Tu School of Agriculture Food nd Wine The University of Adelide Conversion of PUFA to LCPUFA PUFA LCPUFA

More information

Ulk λ PPase. 32 P-Ulk1 32 P-GST-TSC2. Ulk1 GST (TSC2) : Ha-Ulk1 : AMPK. WB: Ha (Ulk1) : Glu. h CON - Glu - A.A WB: LC3 AMPK-WT AMPK-DKO

Ulk λ PPase. 32 P-Ulk1 32 P-GST-TSC2. Ulk1 GST (TSC2) : Ha-Ulk1 : AMPK. WB: Ha (Ulk1) : Glu. h CON - Glu - A.A WB: LC3 AMPK-WT AMPK-DKO DOI: 10.1038/ncb2152 C.C + - + - : Glu b Ulk1 - - + λ PPse c AMPK + - + + : ATP P-GST-TSC2 WB: Flg (Ulk1) WB Ulk1 WB: H (Ulk1) GST (TSC2) C.C d e WT K46R - + - + : H-Ulk1 : AMPK - + - + + + AMPK H-Ulk1

More information

Supplementary information for: Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage

Supplementary information for: Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage Supplementry informtion for: Low one mss nd chnges in the osteocyte network in mice lcking utophgy in the osteolst linege Mrilin Piemontese, Meld Onl, Jinhu Xiong, Li Hn, Jeff D. Thostenson, Mri Almeid,

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION Prentl doi:.8/nture57 Figure S HPMECs LM Cells Cell lines VEGF (ng/ml) Prentl 7. +/-. LM 7. +/-.99 LM 7. +/-.99 Fold COX induction 5 VEGF: - + + + Bevcizum: - - 5 (µg/ml) Reltive MMP LM mock COX MMP LM+

More information

Supplementary Figure S1

Supplementary Figure S1 Supplementry Figure S1 d MAP2 GFAP e MAP2 GFAP GFAP c f Clindin GFAP Supplementry Figure S1. Neuronl deth nd ltered strocytes in the rin of n ffected child. Neuron specific MAP2 ntiody stining in the hippocmpus

More information

Supplementary figure 1

Supplementary figure 1 Supplementry figure 1 Dy 8 post LCMV infection Vsculr Assoc. Prenchym Dy 3 post LCMV infection 1 5 6.7.29 1 4 1 3 1 2 88.9 4.16 1 2 1 3 1 4 1 5 1 5 1.59 5.97 1 4 1 3 1 2 21.4 71 1 2 1 3 1 4 1 5 1 5.59.22

More information

Supplementary Figure 1

Supplementary Figure 1 Supplementry Figure 1 c d Wistr SHR Wistr AF-353 SHR AF-353 n = 6 n = 6 n = 28 n = 3 n = 12 n = 12 Supplementry Figure 1 Neurophysiologicl properties of petrosl chemoreceptive neurones in Wistr nd SH rts.

More information

British Journal of Nutrition

British Journal of Nutrition (11), 16, 1449 1456 q The Authors 11 doi:1.117/s71145111917 Fish oil comined with SCFA synergisticlly prevent tissue ccumultion of NEFA during weight loss in oese mice Miken H. Pedersen 1,, Lotte Luritzen

More information

11/7/2011. Disclosures. Psoriatic Arthritis (PsA) DC-STAMP I II III IV. None

11/7/2011. Disclosures. Psoriatic Arthritis (PsA) DC-STAMP I II III IV. None unstimulte stimulte 11/7/11 Ientifiction of Unique Suset + (Denritic Cell-Specific Trnsmemrne Protein) T cells with Th17 Signture in Psoritic rthritis () Ptients Disclosures None Y.H. Chiu, E.M. Schwrz,

More information

Supplementary Figure 1

Supplementary Figure 1 Roles of endoplsmic reticulum stress-medited poptosis in -polrized mcrophges during mycocteril infections Supplementry informtion Yun-Ji Lim, Min-Hee Yi, Ji-Ae Choi, Jung-hwn Lee, Ji-Ye Hn, Sung-Hee Jo,

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION DOI:.38/nc393 Nnog DAPI Nnog/DAPI c-jun DAPI c-jun/dapi c e Reltive expression to Gpdh mescs ( Feeder free) mescs ( Feeder) MEFs.5 MEFs ipscs ESCs..5 p=.24 p=.483 p=.22. JunB JunD Fos Fr Fr2 ATF2 ATF3

More information

SUPPLEMENTARY INFORMATION. Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis

SUPPLEMENTARY INFORMATION. Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis SUPPLEMENTARY INRMATION Cytochrome P-E1 promotes fst food-medited heptic fibrosis Mohmed A. Abdelmegeed, Youngshim Choi, Grzegorz Godlewski b, Seung-Kwon H, Atryee Bnerjee, Sehwn Jng, nd Byoung-Joon Song

More information

SESSIONE I: RELATORI. Ghrelin: from oroxigenic signal to metabolic master regulator?

SESSIONE I: RELATORI. Ghrelin: from oroxigenic signal to metabolic master regulator? SESSIONE I: RELATORI Ghrelin: from oroxigenic signl to metbolic mster regultor? Prof. Rocco Brzzoni Professore ssocito di Medicin Intern Università degli Studi di Trieste Ghrelin: d segnle oressizznte

More information

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis Supplementry Informtion PDGF-BB secreted y preosteoclsts induces ngiogenesis during coupling with osteogenesis Hui Xie, Zhung Cui, Long Wng, Zhuying Xi, Yin Hu, Lingling Xin, Chngjun Li, Ling Xie, Jnet

More information

Activation of Bile Acid Signaling Shapes the Gut Microbiota to Improve Diabetes and Fatty Liver Disease

Activation of Bile Acid Signaling Shapes the Gut Microbiota to Improve Diabetes and Fatty Liver Disease Activation of Bile Acid Signaling Shapes the Gut Microbiota to Improve Diabetes and Fatty Liver Disease John Chiang, Ph.D. Northeast Ohio Medical University Rootstown, OH, USA International Conference

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION doi:.38/nture73 Glucose SSP THF Methyl- THF Purines 3- PG PHGDH PSAT PSPH Glycine SHMT GSH Lctte Pyruvte ROS TCA Cycle Glucose p53 p Purines 3- PG PHGDH PSAT PSPH Glycine SHMT GSH Lctte Pyruvte ROS TCA

More information

Northern blot analysis

Northern blot analysis Northern blot nlysis RNA SCD RNA SCD FAS C c-9 t-1 C c-9 t-1 PRE PI PDMI PRE PI PDMI PRE PDMI PIM An W c-9, t-11 t-1, c-12 C 5 2 4 1 um C 5 2 4 1 um Angus dipocytes expressed SCD higher thn Wgyu dipocyte

More information

% Inhibition of MERS pseudovirus infection. 0 h 0.5 h 1 h 2 h 4 h 6 h Time after virus addition

% Inhibition of MERS pseudovirus infection. 0 h 0.5 h 1 h 2 h 4 h 6 h Time after virus addition % Inhiition of MERS pseudovirus infection 1 8 h.5 h 1 h 2 h 4 h 6 h Time fter virus ddition Supplementry Figure S1. Inhiition of on MERS pseudovirus infection t the different intervls postinfection. A

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION { OI: 1.138/n31 Srifie n nlyze APs on week 1 s of iet 1 4 6 High-ft iet BrU High-ft iet BrU 4 High-ft iet BrU 6 High-ft iet BrU Lin - Lin - : C34 + : C9 + 1 1 3 1 4 1 5 C45 1 C34 1 1 1 1 3 1 4 1 5 S-1

More information

Abstract ABSTRACT #69. Abstract. Introduction & Methods. Methods & Results. Results. Results & Conclusions

Abstract ABSTRACT #69. Abstract. Introduction & Methods. Methods & Results. Results. Results & Conclusions Effects of dietry β-glucn on Growth Performnce, Dirrhe, nd Gut Permeility of Wening Pigs Experimentlly Infected with Pthogenic E. coli Kwngwook Kim, Amy Ehrlich, Vivin Perng, Jennifer Chse, Helen Ryould,

More information

Effect of environmental stress on biochemical and physiological features in cultured fish

Effect of environmental stress on biochemical and physiological features in cultured fish Effect of environmentl stress on biochemicl nd physiologicl fetures in cultured fish Toshiki Nkno, Toshiysu Ymguchi, nd Yoshihiro Ochii Grd. Sch. Agric. Sci., Tohoku Univ., Sendi, Jpn Fmous Smuri Mr. Msmune

More information

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess

More information

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin Signling y promotes lterntive ctivtion of mcrophges to limit endotoxemi nd oesity-ssocited resistnce to insulin Nture Americ, Inc. All rights reserved. Jn Muer,9, Bhgirth Chursi,9, Juli Goldu, Merly C

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION DOI: 1.138/nc286 Figure S1 e f Medium DMSO AktVIII PP242 Rp S6K1-I Gr1 + + + + + + Strvtion + + + + + IB: Akt-pT38 IB: Akt K-pT389 K IB: Rptor Gr1 shs6k1-a shs6k1-b shs6k1-c shrictor shrptor Gr1 c IB:

More information

A. Kinoshita 1, L. Locher 2, R. Tienken 3, U. Meyer 3, S. Dänicke 3, J. Rehage 4, K. Huber 5

A. Kinoshita 1, L. Locher 2, R. Tienken 3, U. Meyer 3, S. Dänicke 3, J. Rehage 4, K. Huber 5 Effects of dietry nicin supplementtion on heptic expression of FoxO nd genes involved in glucose production in diry cows during the trnsition period A. Kinoshit, L. Locher, R. Tienken 3, U. Meyer 3, S.

More information

Primers used for real time qpcr

Primers used for real time qpcr Supplementry Tble 1. Primers used for rel time qpcr Gene Accession number Forwrd/reverse primers Tgfα Tgfβ1 Hgf Cyclin A2 Cyclin B1 Cyclin D1 Cyclin E1 FoxM1 p21 Lrt Cyp26A1 CrbpI Rrβ Bcmo1 Bcmo2 NM_31199

More information

Feeding state and age dependent changes in melaninconcentrating hormone expression in the hypothalamus of broiler chickens

Feeding state and age dependent changes in melaninconcentrating hormone expression in the hypothalamus of broiler chickens Supplementry Mterils Epub: No 2017_23 Vol. 65, 2018 https://doi.org/10.183/bp.2017_23 Regulr pper Feeding stte nd ge dependent chnges in melninconcentrting hormone expression in the hypothlmus of broiler

More information

DOI /mnfr

DOI /mnfr 3 Mol. Nutr. Food Res. 15, 59, 3 35 DOI 1.1/mnfr.1399 RESEARCH ARTICLE Ursolic cid improves lipid nd glucose metolism in high-ft-fed C57BL/6J mice y ctivting peroxisome prolifertor-ctivted receptor lph

More information

Molecular Analysis of BRCA1 in Human Breast Cancer. Cells Under Oxidative Stress

Molecular Analysis of BRCA1 in Human Breast Cancer. Cells Under Oxidative Stress Moleculr Anlysis of BRCA1 in Humn Brest Cncer Cells Under Oxidtive Stress Brin L. Gilmore 1, Ynping Ling 1, Crly E. Winton 1,2, Ky Ptel 1, Vsile Krgeorge 1, A. Cmeron Vrno 1,3, Willim Dernley 1, Zhi Sheng

More information

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei

More information

The effect of encapsulated butyric acid and zinc on performance, gut integrity and meat quality in male broiler chickens 1

The effect of encapsulated butyric acid and zinc on performance, gut integrity and meat quality in male broiler chickens 1 The effect of encpsulted utyric cid nd zinc on performnce, gut integrity nd met qulity in mle roiler chickens 1 Astrct This study evluted the impct of encpsulted utyric cid nd zinc (ButiPEARL Z) on performnce

More information

NappHS. rrna. transcript abundance. NappHS relative con W+W 0.8. nicotine [µg mg -1 FM]

NappHS. rrna. transcript abundance. NappHS relative con W+W 0.8. nicotine [µg mg -1 FM] (A) W+OS 3 min 6 min con L S L S RNA loding control NppHS rrna (B) (C) 8 1 k NppHS reltive trnscript undnce 6 4.5 *** *** *** *** 3 k. + + + line 1 line (D) nicotine [µg mg -1 FM] 1..8.4. con W+W Supplementl

More information

D14 D 10 D 7. Untreated CYTOXAN 5-FU

D14 D 10 D 7. Untreated CYTOXAN 5-FU Dipeptidylpeptidse Negtively Regultes Colony Stimulting Fctor Activity nd Stress Hemtopoiesis. Hl E. Broxmeyer, Jonthn Hoggtt, Hether A. O Lery, Chrlie Mntel, Brhmnnd R. Chitteti, Scott Cooper, Steven

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION Supplementry Tble 1. Sttistics of dt sets nd structure refinement PYL1 po PYL2/ABA PYL2 po PYL2/ABA/HAB1 PDB code 3KAY 3KAZ 3KB0 3KB3 Dt collection APS bem line 21-ID 21-ID 21-ID 21-ID Spce group P6 5

More information

Effect of kazunoko lipid on the concentrations of plasma glucose and lipids and liver lipids in mice

Effect of kazunoko lipid on the concentrations of plasma glucose and lipids and liver lipids in mice Effect of kzunoko lipid on the concentrtions of plsm glucose nd lipids nd liver lipids in mice Ntionl Food Reserch Institute Tomoyuki Higuchi, Nouy Shiri nd Hirmitsu Suzuki INTRODUCTION Kzunoko, which

More information

Chow KD CR HFD. Fed Fast Refed

Chow KD CR HFD. Fed Fast Refed Supplementry Figure 1 Control d/d Chow KD CR Fed Fst Refed Supplementry Figure 1: Liver expression in diet nd disese models. () expression in the livers of ontrol nd d/d mie. () expression in the livers

More information

Supplementary Figure 1

Supplementary Figure 1 doi: 1.138/nture6188 SUPPLEMENTARY INFORMATION Supplementry Figure 1 c CFU-F colonies per 1 5 stroml cells 14 12 1 8 6 4 2 Mtrigel plug Neg. MCF7/Rs MDA-MB-231 * * MCF7/Rs-Lung MDA-MB-231-Lung MCF7/Rs-Kidney

More information

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J.,... & Gonzalez, F. J. (215). Intestine-selective

More information

The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats

The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats RESEARCH ARTICLE DIABETES/METABOLISM RESEARCH AND REVIEWS Dietes Met Res Rev 2007; 23: 411 418. Pulished online 30 My 2007 in Wiley InterScience (www.interscience.wiley.com).756 The different mechnisms

More information

Effects of Recombinant Bovine Somatotropin Administration at Breeding on the Cow, Conceptus and Subsequent Offspring Performance of Beef Cattle

Effects of Recombinant Bovine Somatotropin Administration at Breeding on the Cow, Conceptus and Subsequent Offspring Performance of Beef Cattle Effects of Recominnt Bovine Somtotropin Administrtion t Breeding on the Cow, Conceptus nd Susequent Offspring Performnce of Beef Cttle V. R. G. Mercdnte 1, F. M. Cirico 1, D. D. Henry 1, P. L. P. Fontes

More information

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network Clémence D. Côté, Brittany A. Rasmussen, Frank A. Duca, Melika Zadeh-Tahmasebi, Joseph A. Baur, Mira

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION doi:10.1038/nture09663 Scrmle shnlrp3 shcsp1 IL-1β (p17) IL-1β (pg/ml) 2000 1500 1000 500 Wt Nlrp3-/- Ipf-/- 0 APDC IL-1β (p17) Supplementl Figure 1. Mitochondril ROS cn trigger NLRP3 inflmmsome ctivtion,

More information

Effect of supplemental fat from dried distillers grains with solubles or corn oil on cow performance, IGF-1, GH, and NEFA concentrations 1

Effect of supplemental fat from dried distillers grains with solubles or corn oil on cow performance, IGF-1, GH, and NEFA concentrations 1 Effect of supplementl ft from dried distillers grins with solules or corn oil on cow performnce, IGF-1, GH, nd NEFA concentrtions 1 Aigil Brtosh 2, Cody Wright 3, Aimee Wertz-Lutz 4, nd George Perry 5

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION . Norml Physiologicl Conditions. SIRT1 Loss-of-Function S1. Model for the role of SIRT1 in the regultion of memory nd plsticity. () Our findings suggest tht SIRT1 normlly functions in coopertion with YY1,

More information

Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice

Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice Dietologi (217) 6:176 183 DOI 1.17/s125-17-424-4 ARTICLE Effects of heptic glycogen on food intke nd glucose homeostsis re medited y the vgus nerve in mice Ilin López-Solddo 1,2 & Reec Fuentes-Romero 1

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION doi:0.08/nture078 RNse VifHA VifHA βctin 6 Cell lyste IP: ntiha MG VifHA VifHA β ctin 6 7 Cell lyste IP: ntiha Supplementry Figure. Effect of RNse nd MG tretment on the Vif interction., RNse tretment does

More information

Optimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality

Optimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality Optimistion of diets for Atlntic cod (Gdus morhu) roodstock: effect of rchidonic cid on egg & lrvl qulity Dr Gordon Bell, Ms. An Blnco, Dr Bill Roy, Dr Derek Roertson, Dr Jim Henderson nd Mr Richrd Prickett,

More information

Brown adipose tissue activity controls triglyceride clearance

Brown adipose tissue activity controls triglyceride clearance Supplementry informtion Brown dipose tissue ctivity s triglyceride clernce Alexnder Brtelt 1, Oliver T. Bruns 2, Rudolph Reimer 2, Heinz Hohenerg 2, Hrld Ittrich 3, Kersten Peldschus 3, Michel G. Kul 3,

More information

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE Swine Dy 22 Contents EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE B. J. Johnson, J. P. Kyser, J. D. Dunn, A. T. Wyln, S. S. Dritz 1, J.

More information

The Journal of Physiology

The Journal of Physiology J Physiol 595.13 (2017) pp 4379 4398 4379 Impct of perintl exposure to sucrose or high fructose corn syrup (HFCS-55) on diposity nd heptic lipid composition in rt offspring Crl R. Toop 1, Beverly S. Muhlhusler

More information

Supplementary Figure 1

Supplementary Figure 1 Supplementary Figure 1 how HFD how HFD Epi WT p p Hypothalamus p p Inguinal WT T Liver Lean mouse adipocytes p p p p p p Obese mouse adipocytes Kidney Muscle Spleen Heart p p p p p p p p Extracellular

More information

Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity

Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity Dietes, Metolic Syndrome nd Oesity: Trgets nd Therpy Open Access Full Text Article open ccess to scientific nd medicl reserch Originl Reserch Synergistic effects of metformin, resvertrol, nd hydroxymethylutyrte

More information

Effects of Rosiglitazone on Inflammation in Otsuka Long-Evans Tokushima Fatty Rats

Effects of Rosiglitazone on Inflammation in Otsuka Long-Evans Tokushima Fatty Rats Originl Article Koren Dibetes J 21;34:191-199 doi: 1.493/kdj.21.34.3.191 pissn 1976-918 eissn 293-265 Effects of Rosiglitzone on Inflmmtion in Otsuk Long-Evns Tokushim Ftty Rts Jin Woo Lee 1, Il Seong

More information

Chronic high-sodium diet intake after weaning lead to neurogenic hypertension in adult Wistar rats

Chronic high-sodium diet intake after weaning lead to neurogenic hypertension in adult Wistar rats Chronic high-sodium diet intke fter wening led to neurogenic hypertension in dult Wistr rts 1 Pul Mglhães Gomes; 2 Rento Willin Mrtins Sá; 1 Giovn Lopes Aguir; 1 Milede Hnner Sriv Pes; 1 Andréi Crvlho

More information

Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm

Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm Adipocyte in vsculr wll cn induce the rupture of dominl ortic neurysm Hiron Kugo 1 *, Nouhiro Zim 1 *, Hiroki Tnk 2 *, Youhei Mouri 1, Kenichi Yngimoto 3, Kohsuke Hymizu 3,4, Keisuke Hshimoto 1, Tkeshi

More information

British Journal of Nutrition

British Journal of Nutrition British Journl of Nutrition (215), 113, 1862 1875 q The Authors 215 doi:1.117/s7114515121x Anormlities in myo-inositol metolism ssocited with type 2 dietes in mice fed high-ft diet: enefits of dietry myo-inositol

More information

GDF11 Protects against Endothelial Injury and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice

GDF11 Protects against Endothelial Injury and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice originl rticle The Americn Society of Gene & Cell Therpy Protects ginst Endothelil Injury nd Reduces Atherosclerotic Lesion Formtion in Apolipoprotein E-Null Mice Wen Mei, Gungd Xing, Yixing Li 2, Hun

More information

PROVEN ANTICOCCIDIAL IN NEW FORMULATION

PROVEN ANTICOCCIDIAL IN NEW FORMULATION PROVEN ANTICOCCIDIAL IN NEW FORMULATION Coxidin 100 microgrnulte A coccidiosttic dditive for roilers, chickens rered for lying nd turkeys Contins 100 g of monensin sodium per kg Aville s homogenous grnules

More information

Effect of Different Dietary Energy Sources on Induction of Fatty Liver-Hemorrhagic Syndrome in Laying Hens

Effect of Different Dietary Energy Sources on Induction of Fatty Liver-Hemorrhagic Syndrome in Laying Hens Interntionl Journl of Poultry Science 7 (12): 1232-1236, 2008 ISSN 1682-8356 sin Network for Scientific Informtion, 2008 Effect of Different Dietry Energy Sources on Induction of Ftty Liver-Hemorrhgic

More information

TGR5 activation induces intestinal growth and improves intestinal mucositis in mice. Hannelouise Kissow

TGR5 activation induces intestinal growth and improves intestinal mucositis in mice. Hannelouise Kissow TGR5 activation induces intestinal growth and improves intestinal mucositis in mice Hannelouise Kissow Department of Biomedical Sciences Faculty of Health and Medical Sciences Faculty Disclosure x No,

More information

PHYSIOLOGICAL AND PROTEOMIC RESPONSES OF TOBACCO SEEDLINGS EXPOSED TO SILVER NANOPARTICLES

PHYSIOLOGICAL AND PROTEOMIC RESPONSES OF TOBACCO SEEDLINGS EXPOSED TO SILVER NANOPARTICLES PHYSIOLOGICAL AND PROTEOMIC RESPONSES OF TOBACCO SEEDLINGS EXPOSED TO SILVER NANOPARTICLES Rent Bi Deprtment of Biology, Fculty of Science, University of Zgre INTRODUCTION Nnoprticles (NPs) Silver nnoprticles

More information

Effect of Oral Administration of Propylene Glycol on Serum Glucose Concentrations in Periparturient Dairy Cows

Effect of Oral Administration of Propylene Glycol on Serum Glucose Concentrations in Periparturient Dairy Cows Ksetsrt J. (Nt. Sci.) 37 : 145-149 (2003) Effect of Orl Administrtion of Propylene Glycol on Serum Glucose Concentrtions in Periprturient Diry Cows Theer Rukkwmsuk, Nrongpol Petploi, Ing-orn Preechnvinit,

More information

Scientific research on the biological value of olive oil

Scientific research on the biological value of olive oil Scientific reserch on the biologicl vlue olive oil Cov F.G. Ally M. (ed.). L' économie de l' olivier Pr : CIHEAM Options Méditerrnéennes : Série Etudes; n. 1988-V 1988 pges 149-152 Article vilble on le

More information

Supplementary Fig. 1. Aortic micrornas are differentially expressed in PFM v. GFM.

Supplementary Fig. 1. Aortic micrornas are differentially expressed in PFM v. GFM. Reltive expression 5 1 15 2-5 5 (n = 3) (n = 3) GFM nd PFM PFM GFM mmu-mir-145 mmu-mir-143 mmu-mir-72 mmu-mir-22 mmu-mir-27 mmu-mir-125-5p mmu-mir-23 mmu-mir-29 mmu-mir-126-3p mmu-let-7d mmu-let-7c mmu-mir-199-3p

More information

Sandra Grbić Vladimir Lukić Ivan Kovačević Jelena Parojčić Zorica Đurić

Sandra Grbić Vladimir Lukić Ivan Kovačević Jelena Parojčić Zorica Đurić Deprtment of Phrmceuticl Technology nd Cosmetology Fculty of Phrmcy University of Belgrde An investigtion into the possibilities nd limittions of in silico bsorption modeling: GstroPlus TM simultion of

More information

Supporting information

Supporting information Supporting informtion Multiple Univrite Dt Anlysis Revels the Inulin Effects on the High-ft-diet Induced Metolic Altertions in Rt Myocrdium nd Testicles in the Pre-oesity Stte Yixun Dun #, Ynpeng An #,

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION DOI: 1.138/n358 TLR2 nd MyD88 expression in murine mmmry epithelil supopultions. CD24 min plus MRU Myo-epithelil Luminl progenitor (CD61 pos ) Mture luminl (CD61 neg ) CD49f CD61 Reltive expression Krt5

More information

Supplemental Information. Lymphocytes Negatively Regulate NK Cell Activity. via Qa-1b following Viral Infection

Supplemental Information. Lymphocytes Negatively Regulate NK Cell Activity. via Qa-1b following Viral Infection Cell Reports, Volume 21 Supplementl Informtion Lymphocytes Negtively Regulte NK Cell Activity vi Q-1b following Virl Infection Hifeng C. Xu, Jun Hung, Aleksndr A. Pndyr, Elisbeth Lng, Yun Zhung, Christine

More information

British Journal of Nutrition

British Journal of Nutrition British Journl of Nutrition (2012), 108, 2166 2175 q The Authors 2012 doi:10.1017/s0007114512000347 Differentil effects of low-dose resvertrol on diposity nd heptic stetosis in diet-induced oese mice Su-Jung

More information

Research Article Oral Administration of Alkylglycerols Differentially Modulates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice

Research Article Oral Administration of Alkylglycerols Differentially Modulates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice Evidence-Bsed Complementry nd Alterntive Medicine Volume 2013, Article ID 834027, 11 pges http://dx.doi.org/10.1155/2013/834027 Reserch Article Orl Administrtion of Alkylglycerols Differentilly Modultes

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION SUPPLEMEARY IFORMAIO doi:./nture correction to Supplementry Informtion Adenom-linked rrier defects nd microil products drive IL-/IL-7-medited tumour growth Sergei I. Grivennikov, Kepeng Wng, Dniel Mucid,

More information

Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation and atherosclerosis in Ldlr -/- mice.

Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation and atherosclerosis in Ldlr -/- mice. Nringenin prevents cholesterol-induced systemic inflmmtion, metolic dysregultion nd therosclerosis in Ldlr -/- mice. Juli M. Assini 1,2, Erin E. Mulvihill 1,2, Brin G. Sutherlnd 1, Dwn E. Telford 1,3,

More information

The Journal of Physiology

The Journal of Physiology J Physiol 596.4 (218) pp 623 645 623 Restortion of metolic helth y decresed consumption of rnched-chin mino cids Nicole E. Cummings 1,2,3, Elizeth M. Willims 1,2,IldikoKsz 4, Elizeth N. Konon 1,2, Michel

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION SUPPLEMENTARY INFORMATION doi:1.138/nture1188 1mM CCl 2 (min) 3 4 6 CCl 2 (mm) for 4min.1. 1 (mm) Pro- d WT GdCl 3 R-68 -/- P2x7r -/- -/- Csp1 -/- WT -/- P2x7r -/- -/- Csp1 -/- Csp1 (p2) (p17) Pro-Csp1

More information

ZL ZDF ZDF + E2 *** Visceral (g) ZDF

ZL ZDF ZDF + E2 *** Visceral (g) ZDF Body Weight (g) 4 3 2 1 ** * ZL ZDF 6 8 1 12 14 16 Age (weeks) B * Sub-cutaneous (g) 16 12 8 4 ZL ZDF Visceral (g) 25 2 15 1 5 ZL ZDF Total fat pad weight (g) 4 3 2 1 ZDF ZL Supplemental Figure 1: Effect

More information

Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats

Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats ORIGINAL ARTICLE Koren J Intern Med 218;33:347-355 Compound K ttenutes glucose intolernce nd heptic stetosis through AMPK-dependent pthwys in type 2 dibetic OLETF rts Yoo-Cheol Hwng 1, D-Hee Oh 1, Moon

More information

Supplemental Information Supplementary Table 1. Tph1+/+ Tph1 / Analyte Supplementary Table 2. Tissue Vehicle LP value

Supplemental Information Supplementary Table 1. Tph1+/+ Tph1 / Analyte Supplementary Table 2. Tissue Vehicle LP value Supplemental Information Supplementary Table. Urinary and adipose tissue catecholamines in Tph +/+ and Tph / mice fed a high fat diet for weeks. Tph +/+ Tph / Analyte ewat ibat ewat ibat Urine (ng/ml)

More information

Role of hydroxytyrosol in ameliorating effects of high fat

Role of hydroxytyrosol in ameliorating effects of high fat Role of hydroxytyrosol in meliorting effects of high ft diet on mle rts CNS Hyder A. N. Al-Zmely, Zen Shkir Mhmoud Al -Tmemi Dept. of physiology nd biochemistry, College of veterinry Medicine, AL-Qssim

More information

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice Online Sumissions: http://www.wjgnet.com/1948-938of fice wjd@wjgnet.com doi:239/wjd.v3.i.94 World J Dietes 212 My 1; 3(): 94-14 ISSN 1948-938 (online) 212 Bishideng. All rights reserved. ORIGINAL ARTICLE

More information

Research Article Carvacrol Protects against Hepatic Steatosis in Mice Fed a High-Fat Diet by Enhancing SIRT1-AMPK Signaling

Research Article Carvacrol Protects against Hepatic Steatosis in Mice Fed a High-Fat Diet by Enhancing SIRT1-AMPK Signaling Hindwi Pulishing Corportion Evidence-Bsed Complementry nd Alterntive Medicine Volume 3, Article ID 9, pges http://dx.doi.org/.55/3/9 Reserch Article Crvcrol Protects ginst Heptic Stetosis in Mice Fed High-Ft

More information

Kumar et al. Kumar et al. BMC Complementary and Alternative Medicine 2013, 13:273

Kumar et al. Kumar et al. BMC Complementary and Alternative Medicine 2013, 13:273 Umelliferone β-d-glctopyrnoside from Aegle mrmelos (L.) corr. n ethnomedicinl plnt with ntidietic, ntihyperlipidemic nd ntioxidtive ctivity Kumr et l. Kumr et l. BMC Complementry nd Alterntive Medicine

More information

Intestinal microbiota and energy balance pro s and con s

Intestinal microbiota and energy balance pro s and con s Technicl University of Munich Nutrition nd Immunology Intestinl microiot nd energy lnce pro s nd con s Prof. Dr. Dirk Hller Chir of Nutrition nd Immunology School of Life Sciences Weihenstephn (WZW) Reserch

More information

Supplementary Figure S1

Supplementary Figure S1 Supplementry Figure S Connexin4 TroponinI Merge Plsm memrne Met Intrcellulr Met Supplementry Figure S H9c rt crdiomyolsts cell line. () Immunofluorescence of crdic mrkers: Connexin4 (green) nd TroponinI

More information

Successful completion of Phase I clinical trial of AMPK activator O304

Successful completion of Phase I clinical trial of AMPK activator O304 Successful completion of Phase I clinical trial of AMPK activator O304 O304 is safe and very well tolerated in young healthy subjects, in middle aged obese subjects, and in type 2 diabetics in combination

More information

Supplementary information

Supplementary information Supplementry informtion Unsturted liphtic lcohol s nturl lignd for mouse odornt receptor Keiichi Yoshikw, Hiroki Nkgw, Noki Mori, Hidenori Wtne nd Kzushige Touhr* Deprtment of Applied Biologicl Chemistry,

More information

Supplementary Information. Title: RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-

Supplementary Information. Title: RAS-MAPK dependence underlies a rational polytherapy strategy in EML4- Supplementry Informtion Title: RAS-MAPK dependence underlies rtionl polytherpy strtegy in EML4- ALK positive lung cncer Authors: Gorjn Hrustnovic, Victor Olivs, Evngelos Pzrentzos, Asmin Tulpule, Surh

More information