Antioxidants & Detoxification

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1 Antioxidants & Detoxification How Antioxidants Help the Body Cleanse and How Supplementation Plays a Role in this Process Canada

2 Antioxidants & Detoxification: What We ll Discuss TOXINS AND THE IMPORTANCE OF DETOXIFICATION THE ROLE ANTIOXIDANTS PLAY IN THE DETOXIFICATION PROCESS HOW SUPPLEMENTATION CAN HELP PROVIDE ANTIOXIDANTS IMPORTANT FOR THIS PROCESS

3 What is a Toxin? Toxins are harmful substances that can build up in our bodies over time through: The air we breathe The foods we eat The stress we put our bodies under on a daily basis

4 Your Health Goal Keep toxins from disrupting normal functions of the body

5 Detoxification Detoxification is the process of removing harmful substances from the body Causes of: External Toxins Internal Toxins Food Additives Bodily Waste Pesticides Digestive Process Chemicals Energy Production Tobacco Products Hormone Synthesis Pollution Stress

6 Toxic Overload We live in a world filled with an abundance of toxic chemicals. Unfortunately, the over abundance of toxins builds up in our bodies causing undue stress. In some instances the liver, gallbladder, kidneys and digestive system can t keep up with the demand placed on them.

7 Toxic Overload Over a period of time, if toxins are not removed, it may adversely affect your health. A build up of toxins without sufficient detoxification support may lead to an increased toxic burden.

factors: Sugar, alcohol, processed foods Lifestyle factors:

8 What Puts Your at Risk? Environmental exposure : Chemicals, smoking, pollution Dietary factors: Sugar, alcohol, processed foods Lifestyle factors: Lack of sleep, lack of physical activity, excess weight High-stress lifestyle: Increased demand on recovery

9 Organs of Detoxification WHAT ARE WE LOOKING TO SUPPORT WITH FOCUSED SUPPLEMENTATION?

10 Your Liver Is the #1 Detoxification Organ In Your Body However, a healthy digestive tract, gallbladder and kidneys are essential for your liver to complete its goal for effective detoxification

11 Your Liver and Toxins The liver's primary function is to sort out and eliminate toxins from the body Toxins are removed from the body in a complex process: Part 1: Neutralize and make toxins easier to excrete Part 2: Excretion (removal from the body)

12 Gastro-Intestinal Function The GI Tract is not just a piece of plumbing. It is an active organ involved in: Immunity An active barrier between you and the outside world; a combination of immune tissue and healthy micro-flora (bacteria) Excretion The intestine finishes the process of digestion and absorption of nutrients and passes unwanted material through for elimination

13 How Antioxidants Fit In The liver detoxification process can be enhanced or undermined depending of what we eat. More than the vitamins and minerals found in fruits and vegetables, the phytochemical compounds that they contain are highly beneficial. Some phytochemicals can support the detoxification process by promoting the normal production of liver detoxifying enzymes and by inhibiting free radicals.

14 How Antioxidants Fit In There are two classification of antioxidants: Those produced by the body (i.e. glutathione) Nutritional antioxidants provided by the diet Both types work together, but antioxidants created by the body are dependent on certain nutrients in the diet. A poor diet can result in a reduction of the natural antioxidants your body produces.

15 How Antioxidants Fit In Did you know that antioxidants support one another? Antioxidants recycle other antioxidants!

16 How Antioxidants Fit In Vitamin C recycles vitamin E Vitamin C is recycled by glutathione Glutathione needs selenium in order to be produced by the liver Anthocyanidines recycle glutathione And the process continues. Vitamin C Vitamin E Glutathione Selenium Anthocyanidines

17 How Antioxidants Fit In Similar to a chain reaction, antioxidants metabolize, producing a compound that triggers detoxification. We can boost our antioxidant levels to help our bodies detoxify and maintain overall health. Source: Saravanakumar D, et al., 2001, Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens, Current topics in Cellular Regulation, 36: pp

18 How Antioxidants Fit In Curcumin, from the South Asian spice tumeric, is not only a highly effective antioxidant, but also it has been shown to protect against mercury buildup in the body. According to recent scientific studies, rats exposed to mercury and then pre and post-treated with curcumin displacyed decreased mercury concentration in tissues than the rats not treated with curcumin. Source: Agarwal R, Goel SK and Behari JR, 2010, Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury, J Appl. Toxicol, 30:5, pp

19 How Antioxidants Fit In Rats not given curcumin demonstrated effects of increased mercury exposure. This study indicates curcumin s potential as An antioxidant A protectant against mercury exposure Source: Agarwal R, Goel SK and Behari JR, 2010, Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury, J Appl. Toxicol, 30:5, pp

20 How Antioxidants Fit In Support normal liver detoxification processes which can help to support: Healthy ageing Optimal health

21 Do We Get Enough Antioxidants? Dietary deficiencies more processed foods in typical Western diets, less nutrient value Less nutritious foods farming practices, soil depleted of nutrients over time Evidence suggests that the amount of some minerals in certain vegetables has declined by 5% to 40%. * *(Davis 2009; Hort Science 44:15-19).

22 How Supplementation Can Help

23 How Can Curcumin Extreme Help? Contains the golden herb' turmeric curcumin in the form of Meriva, which is known to have superior bioavailability and absorption Is an antioxidant Additional benefits include: Helps relieve joint inflammation and associated symptoms such as joint pain when used in conjunction with conventional treatment Helps to promote joint comfort when used in conjunction with conventional treatment A factor in the maintenance of good health

Curcumin Extreme Ingredients Turmeric Extract (Meriva), a complexation of turmeric and soy phospholipids allowing for improved absorption and bioavailability of curcumin.

24 Curcumin Extreme Ingredients Turmeric Extract (Meriva), a complexation of turmeric and soy phospholipids allowing for improved absorption and bioavailability of curcumin. Research showed up to a 20-fold improvement in bioavailablity of curcumin versus standard extracts. Studies have shown that curcumin has antioxidant, antiinflammatory, immune-stimulating, and neuroprotective properties. Preliminary research in people with arthritis found curcumin to be helpful in reducing inflammation and symptoms such as pain and stiffness. Selenium, a required cofactor for selenoproteins such as glutathione.

25 Competitive Landscape Market America - Curcumin Extreme Thompson Turmeric Curcumin* CanPrev Curcumin-Pro* Nature s Way Turmeric Curcuma* Form of Curcumin (curcumin longa) Curcuminoidsphosphatidylcholine complex Curcumin standardized to 95% curcuminoids Curcumin not standardized (not listed/unknown) Curcumin standardized to 95% curcuminoids High bioavailability x x x x x x Selenium 50 mcg x x x

26 How Can Oxygen Extreme Help? Source of antioxidants for the maintenance of good health Helps to enhance cognitive function and memory in adults Contains key botanicals and vitamins Additional benefits include: Used in Herbal Medicine to help slow the progression of disorders of the eye, such as diabetic and hypertensive retinopathy, and macular degeneration Used in Herbal Medicine to help relieve symptoms related to non-complicated chronic venous insufficiency (CVI), such as sensation of swelling, heaviness and tingling of the legs

27 Oxygen Extreme Ingredients Vitamin A (Beta-Carotene) helps to maintain eyesight, skin, membranes and immune function. Vitamin A is also used to help in the development and maintenance of night vision. Vitamin C, also called ascorbic acid is one of the more powerful and well-known antioxidants for the maintenance of good health. Vitamin C helps in connective tissue formation and helps in wound healing. It also helps the body to metabolize fats and proteins. Selenium, a trace element found in soil, is required in small amounts for the maintenance of overall good health. Bilberry, with its powerful antioxidant qualities, contains flavonoids called anthocyanosides, which are found largely in dark-skinned fruits, and act as potent antioxidants in the body, maintaining a state of good health.

28 Oxygen Extreme Ingredients Green Tea Extract is a health-promoting antioxidant rich in polyphenols that have been shown to promote health. Green tea has been known to help boost the immune system and fight off harmful free radicals while also promoting an overall better state of health. Ginkgo Biloba helps to support memory, brain function, mood, cerebral and peripheral circulation, and oxygenation and blood flow. Milk Thistle is used to promote liver health. It contains some of the most potent liver-supporting substances known. Milk thistle has also been shown to protect against free radicals by acting as an antioxidant, protecting the liver and supporting the normal production of new liver cells.

29 Competitive Landscape Ingredient Market America Oxygen Extreme Natural Factors Enriching Blueberry Greens * Thorne Research Planti-Oxidants * Bilberry Extract Milk Thistle Extract Beta-carotene/Vitamin A Vitamin C Selenium Green Tea Extract Ginkgo Biloba Extract Per Serving = 2 capsules Per serving= 1 scoop Per serving= 1 capsule 25 mg x 20 mg 50 mg 7.5 mg x 3 mg x x 200 mg x x 200 mcg x x 300 mg 7.5 mg 50 mg 120 mg 7.5 mg x

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Targeted Health Regimen Every Targeted Health Regimen builds upon the Foundation of Optimal Health Regimen. Liver Health Regimen

Targeted Health Regimen Every Targeted Health Regimen builds upon the Foundation of Optimal Health Regimen. Liver Health Regimen No better nutraceutical combination can be found for healthy hepatic function