Memree. Supports Cognitive Function and Stress Reduction. Memree. Nutrition

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1 Nutrition Memree Supports Cognitive Function and Stress Reduction Memree for Human Nutrition English Memree Memree contains high-quality soy phosphatidylserine and is a trademark of Lonza Ltd, Switzerland.

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3 «Products displaying the Memree quality seal show the consumer that they contain high quality soy phosphatidylserine.» What is Memree? The Memree brand covers a line of products that includes high quality, soy-based, phosphatidylserine (PS). Phosphatidylserine is an important structural component of cell membranes and is found in concentrated amounts in brain cells. Products in the Memree line include: MemreePS MemreePlus MemreePS contains high quality phosphatidylserine which can be used for cognitive health applications. MemreePlus is a proprietary blend of soy-based phosphatidylserine and phosphatidic acid (PA) which can be used for cognitive health, stress reduction and exercise recovery applications. About Lonza Swiss life-science company founded in 1897 One of the world s leading suppliers to the pharmaceutical, healthcare and life-science industries The global leader in the production and support of active pharmaceutical ingredients (API s) based on both chemical as well as biotechnological platforms The global leader in microbial control solutions The world s biggest supplier of vitamin B 3 (Niacin and Niacinamide) and L-carnitine (Carnipure ) Memree Memree contains high-quality soy phosphatidylserine and is a trademark of Lonza Ltd, Switzerland. Memree Supplementation Figure 1: Phospholipid content of brain cells 1 Research has shown that as we age, the amount of PS in our brain cells begins to decline (Fig. 1). While PS is found in dietary sources such as dairy products and organ meats, intake of such products generally decreases as we age. Supplementation with Memree can increase dietary intake of PS and help restore levels of PS in our brain cells. Phospholipid content (mg/g) MemreePlus has the additional benefit of containing phosphatidic acid, a precursor for many important phospholipids. Clinical evidence has shown that MemreePlus supplementation may help decrease stress Age groups (years) White matter Pons Hippocampus 3

4 Phospholipids in the Body Figure 2: Structure of phosphatidylserine and phosphatidic acid, major components of MemreePS and MemreePlus Phosphatidylserine is a specific type of phospholipid. Phospholipids are key components of cell membranes, providing structure and support. They also act as surface active agents, facilitating biological functions at the water-air surfaces in the lungs and intestines. Phospholipids can be further processed by enzymes to provide hormones or neurotransmitters. Glycerol and Phosphate Serine Fatty Acids Glycerol and Phosphate Fatty Acids While found in all cell membranes, phosphatidylserine (Fig. 2) is found in concentrated amounts in brain cells. As a structural component of cell membranes, PS is important for cell membrane fluidity and support. It also serves as an enzyme cofactor and plays a role in apoptosis, or programmed cell death. Research has shown that as we age, the amount of PS in our cells begins to decline 1. Phosphatidylserine Phosphatidic Acid Phosphatidic acid (Fig. 2) is the simplest form of phospholipid and is an important precursor to other phospholipids, including phosphatidylserine. It also acts as a signaling molecule on the cell membrane and can influence membrane curvature. 4

5 Health Benefits and Applications of MemreePS and MemreePlus Cognitive Health Phosphatidylserine has been widely studied as a cognitive health ingredient. Numerous studies have shown that phosphatidylserine helps improve brain functions that decline with age 2,3. Specifically, PS has been shown to improve memory retention and support mental concentration. Furthermore, PS is the only cognitive health ingredient for which the FDA allows a qualified health claim 4. Stress Reduction MemreePlus supplementation has been shown to impact the stress response, including decreasing cortisol levels and distress. In a double blinded, placebo controlled trial, participants took either a MemreePlus supplement or a placebo for three weeks. After three weeks of supplementation, participants completed the Trier Social Stress Test. Salivary and serum cortisol were measured, as was perceived stress. Participants in the 400 mg arm of the study showed statistically significant decreased levels of cortisol and distress after the stress test 5. Exercise Recovery MemreePlus supplementation may also be beneficial in sports recovery. When individuals and athletes engage in vigorous training programs, cortisol levels may rise. High levels of cortisol, however, can impede the recovery process after exercise. Cortisol is a catabolic hormone and breaks down muscle protein into its component amino acids. Cortisol also prevents amino acids from entering muscle cells for muscle tissue repair and rebuilding. Decreasing levels of cortisol could help athletes train harder and help improve the recovery process after exercise. Studies have shown that PS not only lowers cortisol levels after exercise, but also improves muscle soreness and perceptions of well-being 6,7. 5

6 Memree Quality and Safety Quality and Safety at a Glance: Generally Recognized as Safe (GRAS) affirmed status by US FDA Kosher Vegetarian Manufactured according to HACCP and GMP principles Memree Production Process The Memree line of products is produced according to strict safety and quality standards in a state of the art GMP facility. The production process for Memree is carried out by a series of enzymatic reactions starting with soy-derived phospholipids and cabbage derived phospholipase D. The enzymatic reaction is done in water and is free of any solvents. At the end of the process, Memree is extracted and stabilized to a liquid or powder form for use in end consumer applications. Product Line Under the Memree brand, Lonza offers the following products: MemreePS MemreePlus Memree products can be used in dietary supplements and in functional foods and beverages. Table 1 shows the full range of Memree products offered by Lonza. Table 1: Memree products MemreePS (PS only) MemreePlus (PA + PS) Powder % 20 % PS and 20 % PA Liquid 20 % 14.5 % PS and 14.5 % PA Product Applications Cognitive health Cognitive health Stress reduction Exercise recovery 6

7 Customer Support Scientific Support Lonza works in collaboration with universities and research centers around the world to strengthen the scientific backing of MemreePS and MemreePlus. We maintain a database of published literature which is used by our technical experts to provide tailor-made, well researched answers on technical questions. Regulatory Support Our regulatory experts collaborate with authorities and organizations globally to work towards a regulatory situation that is in favor of MemreePS and MemreePlus products. We have years of experience with regulatory dossiers and a track record of successful regulatory initiatives. Formulation Support MemreePS and MemreePlus have a number of technical properties which make them easy to incorporate into dietary supplements and functional foods. MemreePS and MemreePlus come in both liquid and powder forms in a number of different concentrations. Ask us how MemreePS and MemreePlus can be incorporated into your applications. Support in End Consumer Marketing As a raw ingredient manufacturer, we not only actively promote our ingredients on a business-to-business level, but we also support our customers in their communication towards the end consumer. Memree Memree contains high-quality soy phosphatidylserine and is a trademark of Lonza Ltd, Switzerland. References 1 Soderberg M et al. (1990) J Neurochem. 54: Wehrmuller K (2008) ALP Science No Kato-Kataoka A et al. (2010) J Clin Biochem Nutr 47: Food and Drug Administration Summary of Qualified Health Claims Subject to Enforcement Discretion. ucm htm#phosphat 5 Hellhammer J et al. (2004) Stress. 7(2): Kingsley MI et al. (2006) Med Sci Sports Exerc 38(1): Kingsley MI (2006) Med Sci Sports Exerc 36(8):

8 Switzerland Lonza Ltd, Basel Tel memree@lonza.com USA Lonza Inc., Allendale, NJ Tel memree@lonza.com This document is an overview for professionals of published scientific information on phosphatidylserine or a combination of phosphatidylserine and phosphatidic acid and published scientific information on clinical and nutritional trials with phosphatidylserine or phosphatidylserine and phosphatidic acid and its derivatives. No claims are made herein for any particular consumer product, and any use of these statements is the sole responsibility of the user based on his / her independent evaluation. The republication of the statements made herein is prohibited. It is always important to ensure that final communications to the consumer on food and food supplement products containing phosphatidylserine or phosphatidic acid comply with the applicable health claims regulations in the regions / countries where the products are marketed. The recommended use for MemreePS and MemreePlus products is as a nutrient or dietary supplement. The intended use of products containing phosphatidylserine or phosphatidic acid may be subject to different laws and regulations. The statements in this document have not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority. Lonza s Memree line of products is not intended for use to diagnose, treat, cure or prevent any disease. The information contained herein is believed to be correct and corresponds to the latest state of scientific and technical knowledge. However, no warranty is made, either expressed or implied, regarding its accuracy or the results to be obtained from the use of such information and no warranty is expressed or implied concerning the use of these products. The buyer assumes all risks of use and / or handling. No statement is intended or should be construed as a recommendation to infringe any existing patent Lonza Ltd