PureHeart. Beyond Lipids. His Heart. Her Heart. Your Heart. PureHeart

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1 PureHeart Beyond Lipids His Heart. Her Heart. Your Heart. PureHeart

2 PureHeart While routine lipid screening plays an important role in cardiovascular assessment, it doesn t provide the full picture. Current research suggests that there are underlying processes occurring anywhere from the oral cavity to the artery wall that may also be important indicators of overall heart health. Now there is a simple way for doctors and patients to see the bigger picture and achieve better outcomes. PureHeart is a partnership that combines Cleveland HeartLab s advanced cardiovascular biomarker tests with Pure Encapsulations research-based, hypoallergenic, cardiometabolic supplements for a more proactive approach to heart health.* Step 1 - Contact Cleveland HeartLab to order biomarker tests Step 2 - Determine objectives based on test results Step 3 - Select from Pure Encapsulations supplements to support goals Visit for more detailed product and testing information.

3 Cleveland HeartLab s advanced cardiovascular biomarkers help identify underlying processes occurring within the artery wall and body for a more comprehensive cardiovascular assessment. Underlying factors influence each biomarker, including lipid balance, CoQ 10 status, glucose metabolism and oxidative stress. Addressing these factors and monitoring progress provide a more personalized and proactive approach to heart health that includes supplements, medications, a healthy diet and an exercise program.* Biomarker Test(s) Clinical Goal Personalized Products* Cardiovascular Assessment (includes MPO, Lp-PLA 2 Activity, hscrp, ADMA/SDMA, and OxLDL) OmegaCheck Coenzyme Q 10 Vitamin D, 25 OH GlycoMark Advanced Lipid Assessment (includes Standard Lipid Panel, ApoB, ApoA1, sdldl, HDL2b, and Lp(a)) Support vasodilation, glucose homeostasis, healthy cholesterol levels already in the normal range, and weight management * Optimize omega-3 status and omega-6/omega-3 ratio* Optimize CoQ 10 status for cardiovascular support* Encourage healthy vitamin D status* Support insulin receptor function and glucose metabolism* Support lipid balance and healthy cholesterol levels already in the normal range* Metabolic Xtra, EndoLOX, Nitric Oxide Ultra (stick packs), and/or Cardio-C O.N.E. Omega EmulsiSorb CoQ 10 liquid or Ubiquinol-QH 100 mg Vitamin D 3 1,000 IU or Vitamin D 3 liquid Metabolic Xtra or GlucoFunction CholestePure Plus Learn more online at or call , Option 1. Provides weight management support as part of a healthy lifestyle with a reduced calorie diet and regular exercise.

4 Choose From These Take These PERSONALIZED PRODUCTS FOUNDATION PRODUCTS** O.N.E. Omega Vitamin D 3 liquid Vitamin D 3 1,000 IU EmulsiSorb CoQ 10 liquid Ubiquinol-QH 100 mg CholestePure Plus Metabolic Xtra GlucoFunction EndoLOX Cardio-C Nitric Oxide Ultra (stick packs) O.N.E. Multivitamin Magnesium (glycinate) Probiotic-5 The PureHeart Protocol Breakfast Between Lunch Between Dinner 1 softgel 1-4 drops 1-4 capsules 1 serving 1 serving 1 softgel 2 capsules 1 stick pack 1 stick pack 1 softgel 2 capsules 2 capsules 2 capsules Where multiple supplements are suggested, please note that the patient may not require all of them. These are general recommendations. Please follow the recommended dosing of your health professional. **These are recommendations to be used for foundational support.

5 Foundation Products** Highly absorbable and gentle formula High-strength probiotic blend Take These Daily multivitamin These core products help build the nutritional foundation needed for healthy cardiovascular function.* O.N.E. Multivitamin Provides vitamins A, B, C, D and E in highly bioavailable forms Provides Metafolin L-5-methyltetrahydrofolate (L-5-MTHF) and a comprehensive antioxidant complex, including alpha lipoic acid, lutein and sustained-release CoQ10 Convenient, one-capsule-per-day dosing Magnesium (glycinate) Offers a highly bioavailable magnesium chelate, supporting the metabolism and utilization of many essential nutrients* Helps activate neuromuscular contractions, cardiac function and the regulation of the acid-alkaline balance in the body* Gentle formula for a sensitive G.I. tract* Probiotic-5 Provides 10 billion CFU per capsule of five beneficial bacteria strains Combines lactobacilli and bifidobacteria to promote G.I. tract health and comfort, immune cell function, and overall health* Contains no gluten, dairy or soy **These are recommendations to be used for foundational support.

6 Personalized Products Select from these targeted formulas to support your personalized cardiometabolic health goals.* Daily omega- 3 support O.N.E. Omega 1,000 mg per softgel of EPA/DHA in triglyceride form, providing powerful omega-3 fatty acid support for cardiovascular, joint, cognitive and skin health* Offers double the potency of other fish oils in a convenient, once-daily dose Choose From These Potent cholecalciferol form Micellized CoQ 10 Active antioxidant form Vitamin D 3 (1,000 IU or liquid) Provides potential support for breast, prostate, cardiovascular, colon and immune health* Active cholecalciferol form in a variety of dosing options EmulsiSorb CoQ 10 liquid Offers micellized coenzyme Q 10 to enhance bioavailability and minimize bile dependency for absorption* Promotes antioxidant defense and energy metabolism particularly for tissues that require a lot of energy, such as heart muscle and periodontal tissue* Ubiquinol-QH 100 mg Ubiquinol is the active antioxidant form of CoQ 10, the preferred form for individuals over 40 or those experiencing increased oxidative stress* Offers 100 mg of ubiquinol per capsule Nitric oxide support* Nitric Oxide Ultra (stick packs) Promotes arterial flexibility and endothelial function to support vascular health* Offers a blend of CranLoad fruit extracts, citrulline, magnesium and other nutrients to support healthy blood flow* Enhances nitric oxide production with citrulline, which may promote plasma arginine levels to a greater degree than arginine supplementation*

7 Supports healthy lipid metabolism* CholestePure Plus Offers a unique blend of highly researched phytosterol esters and Bergamonte to support healthy cholesterol, triglyceride and plasma glucose levels already in the normal range* Targets HMG CoA reductase with flavonoid-rich bergamot orange extract* Choose From These Supports insulin function and lipid balance* Promotes healthy glucose metabolism* Supports vascular function* Maintains healthy CRP balance* Metabolic Xtra Supports glucose homeostasis with berberine, alpha lipoic acid, Zychrome chromium and resveratrol* Promotes insulin receptor function and signaling* Targets fatty acid oxidation, muscle glucose uptake and insulin sensitivity by influencing AMPK and SIRT1 expression* GlucoFunction Combines key nutrients, antioxidants and herbal extracts to promote broad-spectrum glucose metabolism support* Contains polyphenol polymers from cinnamon extract to promote healthy glucose function, lipid metabolism and blood flow* Supports healthy glucose metabolism by promoting healthy mitochondrial function with alpha lipoic acid* EndoLOX Provides endothelial antioxidant protection and maintains healthy vascular function and lipoprotein integrity with N-acetyl-cysteine (NAC), resveratrol, pomegranate and olive fruit* Helps maintain cytokine balance and promote antioxidant defenses with Oligonol polyphenol extract* Encourages healthy glycemic response and helps maintain healthy LOX-1 expression with berberine* Cardio-C Contains PureWay-C to support key metabolic antioxidant and enzyme activities* Provides PhytoCardio proprietary blend and pomegranate extract for targeted lipid membrane antioxidant protection and arterial health* Other PureHeart Recommendations: Nitric Oxide Ultra (capsules), Resveratrol EXTRA, PureHeart K 2 D

8 490 Boston Post Rd, Sudbury, MA PureHeart Nothing But Pure The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems. PHT616