The EFSA Journal (2005) 288, 1-7
|
|
- Leon Randall
- 5 years ago
- Views:
Transcription
1 The EFSA Journal (2005) 288, 1-7 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the modification of terms of authorisation of the micro-organism preparation of Bacillus cereus var. toyoi (NCIMB 40112/CNCM I-1012) (Toyocerin ) authorised as a feed additive in accordance with Council Directive 70/524/EEC (Question N o EFSA-Q ) Adopted on 30 November 2005 SUMMARY The European Food Safety Authority received a request to assess the compatibility of the micro-organism product Toyocerin with the coccidiostats diclazuril, narasinnicarbazin and maduramicin ammonium when mixed in chicken feed. An in vitro study has been performed, in which the viability of the micro-organism (Bacillus cereus var. toyoi) was assessed in experimental chicken feeds during three months of storage in the presence of diclazuril (1 mg kg -1 ), narasin-nicarbazin (100 mg kg -1 ), and maduramicin (5 mg kg -1 ). None of the coccidiostats affected the stability of the product in feed in comparison to the control. In an animal study the same experimental feeds that were used in the stability test were fed to 40 female one-day old broiler chickens for 28 days. Each experimental group (including the control) consisted of ten animals (five replicates). The faeces were analysed for B. cereus var. toyoi content on day 14 and at the end of the experiment. There were no statistically significant differences either between the time points or treatments. Nothing in the data provided suggests that an incompatibility exists between B. cereus var. toyoi (Toyocerin ) and the tested coccidiostats diclazuril, narasin-nicarbazin and maduramicin ammonium, either on storage or when fed to chickens for fattening. Keywords: Bacillus cereus var. toyoi, coccidiostat, diclazuril, narasin-nicarbazin, maduramicin ammonium, compatibility, chickens for fattening
2 Opinion on Toyocerin 2/7 BACKGROUND Regulation (EC) No 1831/ establishes the rules governing the Community authorisation of additives for use in animal nutrition. In particular, Article 4(1) of that Regulation lies down that any person seeking an authorisation for a feed additive or for a new use of a feed additive shall submit an application in accordance with Article 7. The European Commission received a request from ASAHI VET SA 2 to modify the Annex entry of Directive 70/524/EEC to allow the use of the product Toyocerin in feed for chickens for fattening containing the coccidiostats diclazuril, narasin-nicarbazin and maduramicin ammonium under the conditions set out in Table 1. According to Article 7(1) of Regulation (EC) No 1831/2003, the Commission forwarded the application to the European Food Safety Authority (EFSA), as an application under Article 4.1 (authorisation of a feed additive or new use of a feed additive). EFSA received directly from the applicant the dossier in support of this application. According to Article 8 of that Regulation, EFSA, after verifying the particulars and documents submitted by the applicant, shall undertake an assessment in order to determine whether the feed additive complies with the conditions laid down in Article 5. The particulars and documents in support of the application were considered valid by EFSA as of 04 of May of The additive Toyocerin is a preparation of Bacillus cereus var. toyoi (NCIMB 40112/CNCM I-1012). This product is already permanently authorised for its use in piglets up to 4 months, pigs for fattening and sows (E 1701), and was provisionally authorised (No 1) for chickens for fattening, laying hens, calves, cattle for fattening, breeding does and rabbits for fattening until 7 October 2004, including the authorisation for its use in combination with monensin sodium, lasalocid sodium, salinomycin sodium, decoquinate, robenidine, narasin and halofuginone. It is currently undergoing assessment for permanent authorisation for cattle for fattening, chickens for fattening and rabbits for fattening. The Scientific Committee on Animal Nutrition (SCAN) issued an opinion on the use of Toyocerin on toxin production and resistance to antibiotics on 5 December On 7 May 2004, EFSA issued an opinion on the efficacy of this product in feeds for pigs for fattening 4. TERMS OF REFERENCE According to Article 8 of Regulation (EC) No 1831/2003 EFSA shall determine whether the feed additive complies with the conditions laid down in Article 5. Therefore, EFSA shall deliver an opinion on the safety for the target animals, human user and consumer and the environment and on the efficacy of the micro-organism preparation of Bacillus cereus var. toyoi (NCIMB 40112/CNCM I-1012) (Toyocerin), when used under the conditions described in Table 1, taking into account the background and the information submitted by the applicant. Taking into consideration that the product is already permanently authorised for its use in piglets up to 4 months, pigs for fattening and sows and currently undergoing evaluation for permanent approval for chickens for fattening, the current assessment shall focus on the impact of the mixing of the micro-organism product Toyocerin with the coccidiostats diclazuril, narasin-nicarbazin and maduramicin ammonium in feed for chickens for fattening, when used under the conditions set out in Table 1. 1 OJ L 268, , p Asahi Vet, S.A. Avinguda de La Llana, 123. Polígono Industrial La Llana Ap. correos 283. E Rubí (Barcelona), Spain. Company name changed to RUBINUM, S.A. on 1 st April
3 Opinion on Toyocerin 3/7 Table 1. Proposal for inclusion of Toyocerin in the annex of Directive 70/524/EEC, as proposed by the applicant (proposed modifications in bold). EC No E 1701 Additive Bacillus cereus var. toyoi NCIMB 40112/CNCM I-1012 [Toyocerin] Chemical formula, description Preparation of Bacillus cereus var. toyoi containing a minimum of 1x10 10 CFU g -1 additive Species or category of animal Chickens for fattening Maximum age Minimum content Maximum content CFU kg -1 of complete feedingstuff x x 10 9 Other provisions In the directions for use of the additive and premixture indicate the storage temperature, storage life and stability to pelleting. May be used in compound feed containing the permitted coccidiostats: monensin sodium, lasolacid sodium, salinomycin sodium, decoquinate, robenidine, narasin, halofuginone, diclazuil, narasin/nicarbazin, maduramicin ammonium Period of authorisation
4 Opinion on Toyocerin 4/7 ASSESSMENT 1- Introduction Toyocerin is marketed as two commercial preparations, as feed additive (concentration of B. cereus var. toyoi CFU g -1 ) and as a premixture (concentration of B. cereus var. toyoi 10 9 CFU g -1 ). The recommended dosage range for chickens for fattening is x 10 9 CFU kg -1 feedingstuffs. 2- Compatibility with the coccidiostats diclazuril, narasin-nicarbazin and maduramicin ammonium Experimental feeds Four batches of an experimental chicken feed were prepared all with an inclusion of 1 g Toyocerin premix per kg. The inclusion rates of the coccidiostats in the respective test batches were: 1 mg diclazuril kg -1, 100 mg narasin-nicarbazin kg -1 and 5 mg maduramicin ammonium kg -1. The prepared feed batches were divided into two lots that were either sent to the company for storage trial or used immediately for animal testing. Analysed concentrations of the coccidiostats in the feeds were not presented. The effects of coccidiostats on the storage stability of Toyocerin The storage lasted for three months, after which the numbers of B. cereus var. toyoi in various feeds were determined. No information has been given about the storage conditions (type of package, temperature, humidity, etc.). The results were statistically analysed using analysis of variance and Dunnets's test. The results of the storage trial are presented in Table 2. Table 2. Numbers of B. cereus var. toyoi in feeds supplemented with coccidiostats Counts of B. cereus var. toyoi in feed (10 9 CFU kg -1 ) Coccidiostat 0 1 month 2 month 3 month None Diclazuril Narasin-Nicarbazin Maduramicin ammonium No statistically significant differences were observed between the treatments, and the stability of Toyocerin was not affected by the coccidiostats during the three-month storage. The recovery of B. cereus var. toyoi in faeces of chickens fed with coccidiostat containing feeds The experiment was performed using 40 female day old Ross 308 broiler chickens, which were distributed into 20 pens (two animals per pen). The chickens were fed for 28 days with the experimental feeds containing Toyocerin either alone (control) or together with the tested coccidiostat. The faecal samples (five replicates from two chickens per treatment) were collected after 14 days and at the end of the trial and analysed for the B. cereus var. toyoi counts. The results were statistically analysed using analysis of variance and Dunnets's test. The faecal counts of B. cereus var. toyoi are presented in Table 3.
5 Opinion on Toyocerin 5/7 Table 3. The faecal counts of B. cereus var. toyoi of chicken fed with feeds containing coccidiostats Faecal counts of B. cereus var. toyoi (log10 CFU g -1 ) Coccidiostat 14 days 28 days None Diclazuril Narasin-Nicarbazin Maduramicin ammonium There were no statistically significant differences either between the time points or treatments. Thus the coccidiostats did not have observable effects on the total counts of B. cereus var. toyoi in faeces. The effects of Toyocerin and coccidiostats on animal performance In connection with the compatibility trial, the chicken weight development was also followed by recording the initial and final weight and calculating the average daily weight gain and the daily feed consumption. The results were statistically analysed using analysis of variance and Duncan's multiple range tests (treatment means). The results are expressed in Table 4. Table 4. Performance of chickens fed diets with Toyocerin and coccidiostats (0-28d) Coccidiostat Initial weight (g) Final weight (g) Average daily gain (g) Average daily feed intake (g) Feed conversion Control ab ab Diclazuril ab ab Narasin-Nicarbazin b a Maduramicin ammonium a b a, b: Values in a column with different superscripts are statistically different (P 0.05) The design of the experiment does not allow any assessment of the efficacy of Toyocerin. 3- Assessment of the control methods by the Community Reference Laboratory (CRL) EFSA has verified the CRL report as it relates to the methods used for the control of the active agent in animal feeds. The Executive Summary of the CRL can be found in Annex A. CONCLUSIONS Nothing in the data provided suggests that an incompatibility exists between B. cereus var. toyoi (Toyocerin ) and the tested coccidiostats diclazuril, narasin-nicarbazin and maduramicin ammonium. DOCUMENTATION PROVIDED TO EFSA 1. Dossier on Compatibility of Toyocerin with coccidiostats in chicken for fattening. January Submitted by Asahi Vet, S.A. 2. Complementary information to provide the particulars requested by EFSA on in order to consider as valid and start the assessment of our application reference no. FAD submitted to EU Commission on and received by EFSA on March Submitted by Asahi Vet, S.A.
6 Opinion on Toyocerin 6/7 3. Evaluation report of the Community Reference Laboratory feed additives authorisation on the methods(s) of analysis for Toyocerin. SCIENTIFIC PANEL MEMBERS Arturo Anadón, Margarita Arboix Arzo, Georges Bories, Paul Brantom, Joaquim Brufau de Barberà, Andrew Chesson, Pier Sandro Cocconcelli, Joop de Knecht, Noël Dierick, Gerhard Flachowsky, Anders Franklin, Jürgen Gropp, Ingrid Halle, Anne-Katrine Lundebye Haldorsen, Alberto Mantovani, Kimmo Peltonen, Guido Rychen, Pascal Sanders, Amadeu Soares, Pieter Wester and Wilhelm Windisch ACKNOWLEDGEMENTS The Scientific Panel on Additives and Products or Substances used in Animal Feed wishes to thank Professor Atte von Wright for the contribution to the draft opinion.
7 Opinion on Toyocerin 7/7 ANNEX A. Executive Summary of the Evaluation Report of the Community Reference Laboratory Feed Additives Authorisation on the Method(s) of Analysis for Toyocerin In the current application authorisation is sought for the use of Toyocerin which is a preparation of viable spores of a strain of Bacillus cereus var. toyoi (NCIMB 40112/CNCM I-1012), to be used in feed for chickens for fattening containing the permitted coccidiostats diclazuril, narasin-nicabazin and maduramicin ammonium. Concerning the determination of the active agent of Toyocerin (Bacillus cereus var. toyoi) in the additive, in premixtures and feedingstuffs, the applicant proposed a pour plate count method to enumerate viable counts of the preparation. The method is quantitative and uses a nutrient agar medium (NAM) for analysis of the additive and premixture, and NAM with the addition of antibiotics for feedingstuffs. Within-laboratory validation data were submitted by the applicant regarding the method for determination of the active substance in the additive, in premixtures and in feedingstuffs. Relative standard deviations of repeatability (RSDr) and within-laboratory reproducibility (RSDR) for the performance of the methods in the additive, the premixture and feedingstuffs were appropriate. The limit of quantification (LOQ) for the enumeration method is 5 x 10 3 colony forming units (c.f.u.) per gram of sample. Taking into account the target level of application which ranges between 10 6 c.f.u./g and c.f.u./g of sample (additive, premixture or feedingstuffs) and the acceptable performance characteristics of RSD values, in the opinion of the CRL the proposed methods are fit for the purpose of routine control of the presence of the active agent in the feed additive Toyocerin, in premixtures and in feedingstuffs. The applicant provided data confirming equivalent performance of the method of analysis when enumerating viable spores of the active agent in Toyocerin with and without the presence of three coccidiostats (diclazuril, narasin/nicarbacin and maduramicin ammonium) in broiler feed. In summary, it is considered that the proposed methods for enumeration of viable Bacillus cereus var. toyoi spores as colony forming units in the additive, in premixtures and in feedingstuffs fulfil the requirements for routine control also in the presence of the coccidiostats (diclazuril, narasin/nicarbacin and maduramicin ammonium) at levels typically applied in broiler feed. However, it is recommended to use a larger quantity of feed samples than the proposed 2 g, such as for example 50 g of feed samples to take account of potential sample heterogeneity. For official control purposes, the CRL recommends a fully ring-trial validated method for enumeration of bacilli spores in premixtures and feedingstuffs which was published in a peer reviewed journal (Journal of AOAC International (2003) 86, ). The study demonstrated acceptable methods performance characteristics, since the RSDr was about 1 % and the RSDR was about 6%. On the basis of the supplied documentation, no supplementary experimental work (testing or method validation) is required.
Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed. Adopted on 19 September 2007
The EFSA Journal (2007) 549, 1-11 Safety and efficacy of Toyocerin (Bacillus cereus var. Toyoi) as a feed additive for turkeys 1 Scientific Opinion of the Panel on Additives and Products or Substances
More informationThe EFSA Journal (2004) 96, 1-5
The EFSA Journal (2004) 96, 1-5 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on a request from the Commission on safety of formaldehyde for poultry as feed
More informationThe EFSA Journal (2005) 262, 1-6
The EFSA Journal (2005) 262, 1-6 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety of the enzyme preparation Bio-Feed Wheat for use as feed additive
More informationThe EFSA Journal (2005) 207, 1-6
The EFSA Journal (2005) 207, 1-6 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on a request from the Commission on the safety of the product Lactiferm for
More informationSCIENTIFIC OPINION. Safety and efficacy of Biosaf Sc47 (Saccharomyces cerevisiae) as feed additive for dairy buffaloes 1
The EFSA Journal (2008) 837, 1-10 SCIENTIFIC OPINION Safety and efficacy of Biosaf Sc47 (Saccharomyces cerevisiae) as feed additive for dairy buffaloes 1 Scientific Opinion of the Panel on Additives and
More informationThe EFSA Journal (2005) 171, 1-5
The EFSA Journal (2005) 171, 1-5 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety of the enzymatic product Avizyme 1500 for use as feed additive
More informationThe EFSA Journal (2005) 287, 1-9
The EFSA Journal (2005) 287, 1-9 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety of the new granulate formulation of the enzyme preparation Grindazym
More informationThe EFSA Journal (2005) 231, 1-6
The EFSA Journal (2005) 231, 1-6 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety of the enzyme preparation Econase Wheat Plus for use as feed additive
More informationThe EFSA Journal (2005) 289, 1-6
The EFSA Journal (2005) 289, 1-6 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on a request from the Commission on the safety of the Chelated forms of iron,
More informationScientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed. (Question No EFSA-Q ) Adopted on 18 October 2007
The EFSA Journal (2007) 573, 1-5 Compatibility of the microbial preparation of licheniformis and subtilis (BioPlus 2B) with the coccidiostat lasalocid A sodium in feed for turkeys 1 Scientific Opinion
More informationSafety and efficacy of Biosaf Sc 47 (Saccharomyces cerevisiae) as feed additive for pigs for fattening 1
The EFSA Journal (2007) 585, 1-9 Safety and efficacy of Biosaf Sc 47 (Saccharomyces cerevisiae) as feed additive for pigs for fattening 1 Scientific Opinion of the Panel on Additives and Products or Substances
More informationScientific Opinion on the modification to the formulation of GalliPro and compatibility with formic acid 1
SCIENTIFIC OPINION Scientific Opinion on the modification to the formulation of GalliPro and compatibility with formic acid 1 EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
More informationSafety and efficacy of Levucell SC20/Levucell SC10ME, a preparation of Saccharomyces cerevisiae, as feed additive for lambs for fattening 1,2
The EFSA Journal (2008) 772, 1-9 Safety and efficacy of Levucell SC20/Levucell SC10ME, a preparation of Saccharomyces cerevisiae, as feed additive for lambs for fattening 1,2 Scientific Opinion of the
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Calsporin (Bacillus subtilis) for turkeys for fattening, ducks, geese, pigeons and other game birds for meat production, ducks, geese,
More information(Question No EFSA-Q ) Adopted on 10 July 2007
The EFSA Journal (2007) 520, 1-8 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the enzyme preparation Safizym X (endo-1,4-beta-xylanase)
More informationSafety of the enzymatic preparation Natuphos (3-phytase) for sows 1
The EFSA Journal (2007) 614, 1-5 Safety of the enzymatic preparation Natuphos (3-phytase) for sows 1 Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed (Question
More informationSCIENTIFIC OPINION. Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed. Adopted on 3 February 2009
The EFSA Journal (2009) 970, 1-9 SCIENTIFIC OPINION Safety and efficacy of Biosprint (Saccharomyces cerevisiae) as a feed additive for sows 1 Scientific Opinion of the Panel on Additives and Products or
More informationThe EFSA Journal (2006) 406, 1-11
The EFSA Journal (26) 46, 1-11 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the microbiological product 35, a preparation of
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Natuphos (3-phytase) for minor avian species (quails, pheasants, partridges, guinea fowl, geese, pigeons, ostriches, peacocks, flamingos)
More informationSCIENTIFIC OPINION. Efficacy of the product Levucell SC20/Levucell SC10ME (Saccharomyces cerevisiae) as feed additive for leisure horses 1
The EFSA Journal (2009) 1040, 1-7 SCIENTIFIC OPINION Efficacy of the product Levucell SC20/Levucell SC10ME (Saccharomyces cerevisiae) as feed additive for leisure horses 1 Scientific Opinion of the Panel
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
SCIENTIFIC OPINION Scientific Opinion on the modification of the terms of the authorisation of AveMix XG 10 (endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase) as a feed additive for chickens for fattening
More informationScientific Opinion on modification of the terms of authorisation of VevoVitall (Benzoic acid) as a feed additive for weaned piglets 1
SCIENTIFIC OPINION Scientific Opinion on modification of the terms of authorisation of VevoVitall (Benzoic acid) as a feed additive for weaned piglets 1 EFSA Panel on Additives and Products or Substances
More informationScientific Opinion on the modification of the terms of authorisation of Protural (sodium benzoate) as a feed additive for weaned piglets 1
EFSA Journal 2011;9(12):2443 SCIENTIFIC OPINION Scientific Opinion on the modification of the terms of authorisation of Protural (sodium benzoate) as a feed additive for weaned piglets 1 EFSA Panel on
More informationScientific Opinion on the safety and efficacy of sodium carbonate (soda ash) for all species 1
SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of sodium carbonate (soda ash) for all species 1 EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3 European
More informationOfficial Journal of the European Union L 40/19
11.2.2009 Official Journal of the European Union L 40/19 COMMISSION DIRECTIVE 2009/8/EC of 10 February 2009 amending Annex I to Directive 2002/32/EC of the European Parliament and of the Council as regards
More informationScientific Opinion on the safety and efficacy of Calsporin (Bacillus subtilis) as a feed additive for piglets 1
SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Calsporin (Bacillus subtilis) as a feed additive for piglets 1 EFSA Panel on Additives and Products or Substances used in Animal Feed
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2015;13(7):4199 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Biosprint (Saccharomyces cerevisiae MUCL 39885) for minor ruminant species for meat and milk production
More informationThe EFSA Journal (2006) 384, 1-9
The EFSA Journal (2006) 384, 1-9 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product Biosaf Sc 47, a preparation of Saccharomyces
More informationThe EFSA Journal (2005) 271, 1-6
The EFSA Journal (2005) 271, 1-6 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety of the enzymatic product Kemzyme W Dry for use as feed additive
More informationThe EFSA Journal (2006) 385, 1-9
The EFSA Journal (2006) 385, 1-9 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product Levucell SC20/Levucell SC10ME, a preparation
More informationSCIENTIFIC OPINION. Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed. (Question N EFSA-Q )
The EFSA Journal (2008) 912, 1-13 SCIENTIFIC OPINION Safety and efficacy of Probiotic LACTINA (Lactobacillus acidophilus, Lactobacillus helveticus, Lactobacillus bulgaricus, Lactobacillus lactis, Streptococcus
More informationSCIENTIFIC OPINION. Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed. Adopted on 2 April 2009
The EFSA Journal (2009) 1039, 1-16 SCIENTIFIC OPINION Safety and efficacy of Miya-Gold S (Clostridium butyricum) as feed additive for chickens for fattening 1 Scientific Opinion of the Panel on Additives
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2012;10(5):2681 SCIENTIFIC OPINION Scientific Opinion on safety and efficacy of sodium benzoate, propionic acid and sodium propionate for pigs, poultry, bovines, sheep, goats, rabbits, horses
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2015;13(1):3966 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Biomin C3 (Bifidobacterium animalis ssp. animalis, Lactobacillus salivarius ssp. salivarius and Enterococcus
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2012;10(2):2575 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Natugrain Wheat TS (endo-1,4-beta-xylanase) as feed additive for chickens for fattening, chickens reared
More informationThe EFSA Journal (2006) 336, 1-15
The EFSA Journal (2006) 336, 1-15 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product Calsporin, a preparation of Bacillus
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 3,4
SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Actisaf Sc47 (Saccharomyces cerevisiae) as a feed additive for rabbits for fattening and non foodproducing rabbits 1, 2 EFSA Panel on
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 212;1(6):2728 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of AveMix XG 1 (endo-1,4- beta-xylanase and endo-1,3(4)-beta-glucanase) as feed additive for laying hens and
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2015;13(1):3970 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Bacillus subtilis PB6 (Bacillus subtilis) as a feed additive for laying hens and minor poultry species for
More informationStatement on the safety and efficacy of the product Rosemary extract liquid of natural origin as a technological feed additive for dogs and cats 1
EFSA Journal 2012;10(1):2526 SCIENTIFIC OPINION Statement on the safety and efficacy of the product Rosemary extract liquid of natural origin as a technological feed additive for dogs and cats 1 EFSA Panel
More informationScientific Opinion on the safety and efficacy of InteSwine (Saccharomyces cerevisiae) as a feed additive for weaned piglets 1,2
SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of InteSwine (Saccharomyces cerevisiae) as a feed additive for weaned piglets 1,2 EFSA Panel on Additives and Products or Substances used
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
SCIENTIFIC OPINION Scientific Opinion on modification of the terms of authorisation of a red carotenoid-rich bacterium Paracoccus carotinifaciens (Panaferd-AX) as feed additive for salmon and trout 1 EFSA
More informationMaximum Residue Limits for Clinacox 0.5% (diclazuril) for turkeys for fattening, chickens for fattening and chickens reared for laying 1
The EFSA Journal (2008) 696, 1-12 Maximum Residue Limits for Clinacox 0.5% (diclazuril) for turkeys for fattening, chickens for fattening and chickens reared for laying 1 Updated Scientific Opinion of
More informationScientific Opinion on the safety and efficacy of Bonvital (Enterococcus faecium) as a feed additive for dogs 1
SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Bonvital (Enterococcus faecium) as a feed additive for dogs 1 EFSA Panel on Additives and Products or Substances used in Animal Feed
More informationWithdrawal period for Coxidin for chickens and turkeys for fattening and re-examination of the provisional Maximum Residue Limit 1
The EFSA Journal (2008) 731, 1-14 Withdrawal period for Coxidin for chickens and turkeys for fattening and re-examination of the provisional Maximum Residue Limit 1 Scientific Opinion of the Panel on Additives
More informationSCIENTIFIC OPINION. Safety and efficacy of Avizyme 1505 (endo-1,4-β-xylanase, α-amylase, subtilisin) as a feed additive for turkeys for fattening 1
The EFSA Journal (2009) 1154, 1-11 SCIENTIFIC OPINION Safety and efficacy of Avizyme 1505 (endo-1,4-β-xylanase, α-amylase, subtilisin) as a feed additive for turkeys for fattening 1 Scientific Opinion
More informationThe EFSA Journal (2004) 121, 1-13
The EFSA Journal (2004) 121, 1-13 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on a request from the Commission related to the preliminary assessment of the
More informationSCIENTIFIC OPINION. Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed. (Question No EFSA-Q )
The EFSA Journal (29) 197, 1-2 SCIENTIFIC OPINION Safety and efficacy of the product Ronozyme NP (6-phytase) for use as feed additive for poultry, weaned piglets and pigs for fattening 1 Scientific Opinion
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2015;13(7):4158 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Cylactin (Enterococcus faecium NCIMB 10415) as a feed additive for pigs for fattening, piglets and sows
More informationScientific Opinion on the Safety and Efficacy of thaumatin for all animal species 1
SCIENTIFIC OPINION Scientific Opinion on the Safety and Efficacy of thaumatin for all animal species 1 EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3 ABSTRACT European
More informationScientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed. Adopted on 16 July 2008
The EFSA Journal (2008) 773, 1-13 Safety and efficacy of Ecobiol (Bacillus amyloliquefaciens) as feed additive for chickens for fattening 1 Scientific Opinion of the Panel on Additives and Products or
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
SCIENTIFIC OPINION Statement on the establishment of guidelines for the assessment of additives from the functional group substances for reduction of the contamination of feed by 1 EFSA Panel on Additives
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2015;13(5):4106 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Rovabio Spiky (endo-1,4- beta-xylanase and endo-1,3(4)-beta-glucanase) as a feed additive for turkeys and
More informationEUROPEAN COMMISSION JOINT RESEARCH CENTRE Institute for Reference Materials and Measurements
EUROPEAN COMMISSION JOINT RESEARCH CENTRE Institute for Reference Materials and Measurements Community Reference Laboratory for Feed Additives D08/FSQ/CVH/RL/D(2008) 23555 CRL Evaluation Report on the
More informationSCIENTIFIC OPINION. Safety and efficacy of Natugrain Wheat TS (endo-1,4-β-xylanase) for use as feed additive for chickens for fattening and ducks 1
The EFSA Journal (2009) 1155, 1-14 SCIENTIFIC OPINION Safety and efficacy of Natugrain Wheat TS (endo-1,4-β-xylanase) for use as feed additive for chickens for fattening and ducks 1 Scientific Opinion
More informationSCIENTIFIC OPINION. Safety and efficacy of OPTIPHOS (6-phytase) as a feed additive for finfish. Abstract
SCIENTIFIC OPINION ADOPTED: 21 March 2017 doi: 10.2903/j.efsa.2017.4763 Safety and efficacy of OPTIPHOS (6-phytase) as a feed additive for finfish EFSA Panel on Additives and Products or Substances used
More informationL 243/10 Official Journal of the European Union
L 243/10 Official Journal of the European Union 15.7.2004 COMMISSION REGULATION (EC) No 1288/2004 of 14 July 2004 concerning the permanent authorisation of certain additives and the provisional authorisation
More informationStatement on the preparation of guidance for the assessment of plant/herbal products and their constituents used as feed additives 1
SCIENTIFIC OPINION Statement on the preparation of guidance for the assessment of plant/herbal products and their constituents used as feed additives 1 EFSA Panel on Additives and Products or Substances
More informationEUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL. (adopted on 19 June 2002)
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Scientific Opinions C2 - Management of scientific committees; scientific co-operation and networks REPORT OF THE SCIENTIFIC
More informationScientific Opinion on the safety and efficacy of MycoCell (Saccharomyces cerevisiae) for dairy cows 1
EFSA Journal 2009; 7(10):1353 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of MycoCell (Saccharomyces cerevisiae) for dairy cows 1 EFSA Panel on Additives and Products or Substances
More informationScientific Opinion on the efficacy of Suilectin (Phaseolus vulgaris lectins) as a zootechnical additive for suckling piglets (performance enhancer)
SCIENTIFIC OPINION ADOPTED: 22 October 2015 PUBLISHED: 13 November 2015 doi:10.2903/j.efsa.2015.4276 Scientific Opinion on the efficacy of Suilectin (Phaseolus vulgaris lectins) as a zootechnical additive
More informationLactiferm NCIMB 11181
EUROPEAN COMMISSION DIRECTORATE-GENERAL JOINT RESEARCH CENTRE Institute for Reference Materials and Measurements Community Reference Laboratory Feed Additives D08/FSQ/CVH/CMP/mdr/ARES (2009)242873 CRL
More informationSession 47.
Session 47 montserrat.anguita@efsa.europa.eu Assessment of feed additives that improve the diet utilisation in the European Union M. Anguita, J. Galobart, C. Roncancio-Peña FEEDAP Unit EAAP 2009 Barcelona,
More informationBacillus subtilis GR-101 Aspergillus oryzae GB-107
EUROPEAN COMMISSION JOINT RESEARCH CENTRE Institute for Reference Materials and Measurements Community Reference Laboratory for Feed Additives JRC.DDG.D.6/CvH/DM/hn/ARES (2010) 212880 CRL Evaluation Report
More informationEUROPEAN COMMISSION JOINT RESEARCH CENTRE Institute for Reference Materials and Measurements Community Reference Laboratory for Feed Additives
EUROPEAN COMMISSION JOINT RESEARCH CENTRE Institute for Reference Materials and Measurements Community Reference Laboratory for Feed Additives JRC.DG.D6/CvH/CMP/mds/ARES(2010)757602 CRL Evaluation Report
More information(Question No EFSA-Q ) Adopted on 11 July 2007
The EFSA Journal (2007) 523, 1-11 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety of Zeolite (sodium aluminosilicate, synthetic) for the reduction
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2015;13(9):4239 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of sorbic acid and potassium sorbate when used as technological additives for all animal species based on two
More informationEUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL. (Adopted on 4 December 2002)
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Scientific Opinions C2 - Management of scientific committees; scientific co-operation and networks EVALUATION OF THE
More informationSCIENTIFIC OPINION. Safety and efficacy of 25-hydroxycholecalciferol as a feed additive for poultry and pigs 1
The EFSA Journal (2009) 969, 1-32 SCIENTIFIC OPINION Safety and efficacy of 25-hydroxycholecalciferol as a feed additive for poultry and pigs 1 Scientific Opinion of the Panel on Additives and Products
More informationScientific Opinion on the safety and efficacy of Lactobacillus plantarum (NCIMB 30236) as a silage additive for all species 1,2
EFSA Journal 211;9(6):2275 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Lactobacillus plantarum (NCIMB 3236) as a silage additive for all species 1,2 EFSA Panel on Additives and
More informationFeed Additive Approval An Industry View. Dr Heidi Burrows Regulatory manager
Feed Additive Approval An Industry View Dr Heidi Burrows Regulatory manager Classification of substances and products used in Animal Nutrition Processing Aid (EC No 1831/2003) Veterinary Substance / Products
More informationEUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL. (Adopted on 5 December 2001)
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Scientific Opinions &ÃÃ0DQDJHPHQWÃRIÃVFLHQWLILFÃFRPPLWWHHVÃVFLHQWLILFÃFRRSHUDWLRQÃDQGÃQHWZRUNV 5(32572)7+(6&,(17,),&&200,77((21$1,0$/1875,7,2121352'8&7
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2015;13(3):4055 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Cibenza EP150 (a preparation of Bacillus licheniformis (ATCC 53757) and its protease (EC 3.4.21.19)) as
More informationOfficial Journal of the European Union COMMISSION
L 52/70 COMMISSION COMMISSION RECOMMDATION of 17 February 2004 on the coordinated inspection programme in the field of animal nutrition for the year 2004 in accordance with Council Directive 95/53/EC (Text
More informationSCIENTIFIC OPINION. Abstract
SCIENTIFIC OPINION ADOPTED: 24 January 2017 doi: 10.2903/j.efsa.2017.4704 Efficacy of Saccharomyces cerevisiae (NBRC 0203), Lactobacillus plantarum (NBRC 3070) and Lactobacillus casei (NBRC 3425) as a
More informationEUROPEAN COMMISSION DIRECTORATE-GENERAL JOINT RESEARCH CENTRE Institute for Reference Materials and Measurements
EUROPEAN COMMISSION DIRECTORATE-GENERAL JOINT RESEARCH CENTRE Institute for Reference Materials and Measurements Community Reference Laboratory for Feed Additives D08/FSQ/CVH/RL/2007/9352 CRL Evaluation
More informationScientific Opinion on the safety of a manganese chelate of hydroxy analogue of methionine (Mintrex Mn) as feed additive for all species 1
SCIENTIFIC OPINION Scientific Opinion on the safety of a manganese chelate of hydroxy analogue of methionine (Mintrex Mn) as feed additive for all species 1 EFSA Panel on Additives and Products or Substances
More informationThe EFSA Journal (2005) 195, 1-10
The EFSA Journal (2005) 195, 1-10 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and the bioavailability of product L-Histidine monohydrochloride
More informationScientific Opinion on the safety and efficacy of sodium hydroxide for dogs, cats and ornamental fish 1
EFSA Journal 2012;10(10):2882 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of sodium hydroxide for dogs, cats and ornamental fish 1 EFSA Panel on Additives and Products or Substances
More informationScientific Opinion on the safety of a copper chelate of hydroxy analogue of methionine (Mintrex Cu) as feed additive for all species 1
SCIENTIFIC OPINION Scientific Opinion on the safety of a copper chelate of hydroxy analogue of methionine (Mintrex Cu) as feed additive for all species 1 EFSA Panel on Additives and Products or Substances
More informationScientific Opinion on the safety and efficacy of Lactobacillus brevis (DSMZ 21982) as a silage additive for all species 1,2
EFSA Journal 2012;10(3):2617 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Lactobacillus brevis (DSMZ 21982) as a silage additive for all species 1,2 EFSA Panel on Additives and Products
More informationEUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL. (Adopted on 22 June 2000)
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate B - Scientific Health Opinions Unit B3 - Management of scientific committees II REPORT OF THE SCIENTIFIC COMMITTEE ON ANIMAL
More informationThe EFSA Journal (2006) 337, 1-17
The EFSA Journal (2006) 337, 1-17 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product Amaferm as a feed additive for dairy
More informationScientific Opinion on the safety and efficacy of Formi LHS (potassium diformate) as a feed additive for sows 1
SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Formi LHS (potassium diformate) as a feed additive for sows 1 EFSA Panel on Additives and Products or Substances used in Animal Feed
More informationEUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL. (Adopted on 22 January 2003)
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Scientific Opinions C2 - Management of scientific committees; scientific co-operation and networks REPORT OF THE SCIENTIFIC
More informationThe EFSA Journal (2006) 350, 1-14
The EFSA Journal (2006) 350, 1-14 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed and the Scientific Panel on Genetically Modified Organisms on the safety and
More informationSCIENTIFIC OPINION. (Question No EFSA-Q ) Adopted on 18 November 2008 by the FEEDAP Panel and on 29 October 2008 by the GMO Panel
The EFSA Journal (2008) 871, 1-16 SCIENTIFIC OPINION Safety and efficacy of the product Ronozyme NP (6-phytase) for chickens for fattening 1,2 Scientific Opinion of the Panel on Additives and Products
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
SCIENTIFIC OPINION Scientific Opinion on (6-phytase) as feed additive for chickens and turkeys for fattening, laying hens, and piglets (weaned), pigs for fattening and sows (poultry and pigs) 1 EFSA Panel
More informationSafety and efficacy of Mintrex Zn (Zinc chelate of hydroxy analogue of methionine) as feed additive for all species 1
The EFSA Journal (2008) 694, 1-16 Safety and efficacy of Mintrex Zn (Zinc chelate of hydroxy analogue of methionine) as feed additive for all species 1 Scientific Opinion of the Panel on Additives and
More informationScientific Opinion on the safety and efficacy of synthetic alpha-tocopherol for all animal species 1
EFSA Journal 2012;10(7):2784 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of synthetic alpha-tocopherol for all animal species 1 EFSA Panel on Additives and Products or Substances used
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2013;11(4):3175 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of Provita LE (Enterococcus faecium and Lactobacillus rhamnosus) as a feed additive for calves for rearing
More informationSafety of Allura Red AC in feed for cats and dogs
SCIENTIFIC OPINION ADOPTED: 20 October 2015 PUBLISHED: 10 November 2015 doi:10.2903/j.efsa.2015.4270 Safety of Allura Red AC in feed for cats and dogs EFSA Panel on Additives and Products or Substances
More informationEUROPEAN COMMISSION JOINT RESEARCH CENTRE Institute for Reference Materials and Measurements
EUROPEAN COMMISSION JOINT RESEARCH CENTRE Institute for Reference Materials and Measurements Community Reference Laboratory for Feed Additives D08/FSQ/CVH/SY/D(2009) 35 CRL Evaluation Report on the Analytical
More informationCOMMISSION EUROPEENNE (g:/sanco /tlxcoper/ D(03)410155
Addresses: RP F RP LUX RP B RP IT RP ES RP PO RP UK RP DK RP GR RF IRL RP NL RP DE RP Finland RP Sweden RP Österreich Mission of Cyprus to the EU: Fax - 02.735.45.52 Mission of Czech Republic to the EU:
More informationScientific Opinion on the safety and efficacy of allylhydroxybenzenes (chemical group 18) when used as flavourings for all animal species 1
SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of allylhydroxybenzenes (chemical group 18) when used as flavourings for all animal species 1 EFSA Panel on Additives and Products or Substances
More informationCNCM I-1079 (FAD ; CRL/100166)
EUROPEAN COMMISSION DIRECTORATE GENERAL JOINT RESEARCH CENTRE Directorate D: Institute for Reference Materials and Measurements European Union Reference Laboratory for Feed Additives Ref. Ares(2015)76595-09/01/2015
More informationScientific Opinion on the safety and efficacy of erythrosine in feed for cats and dogs, ornamental fish and reptiles 1
SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of erythrosine in feed for cats and dogs, ornamental fish and reptiles 1 EFSA Panel on Additives and Products or Substances used in Animal
More informationScientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed and the Panel on Genetically Modified Organisms
The EFSA Journal (2008) 627, 1-27 Safety and efficacy of the product Quantum Phytase 5000 L and Quantum Phytase 2500 D (6-phytase) as a feed additive for chickens for fattening, laying hens, turkeys for
More informationScientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all species as preservative and silage additive 1
EFSA Journal 2014;12(6):3731 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all species as preservative and silage additive 1 EFSA Panel on Additives and
More informationSCIENTIFIC OPINION. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2,3
EFSA Journal 2015;13(7):4157 SCIENTIFIC OPINION Scientific Opinion on the safety and efficacy of VevoVitall (benzoic acid) as a feed additive for pigs for reproduction (gestating and lactating sows, boars
More information