Release of Pituitary Growth Hormone by Prostaglandins and Dibutyryl Adenosine Cyclic 3':5'-Monophosphate in the Absence of Protein Synthesis
|
|
- Evelyn Baker
- 5 years ago
- Views:
Transcription
1 Proceedings of the National Academy of Sciences Vol. 67, No. 3, pp. 11t2-1179, November 1970 Release of Pituitary Growth Hormone by Prostaglandins and Dibutyryl Adenosine Cyclic 3':5'-Monophosphate in the Absence of Protein Synthesis Robert M. MacLeodt and Joyce E. Lehmeyer DEPARTMENT OF INTERNAL MEDICINE, UNIVERSITY OF VIRGINIA SCHOOL OF MEDICINE, CHARLOTTESVILLE, VA Communicated by Dietrich Bodenstein, July 24, 1970 Abstract. Effects of prostaglandins on the incorporation of [4,5-3Hlleucine into growth hormone and its subsequent release into the incubation medium were studied. Incubation of rat anterior pituitary glands with 10- M prostaglandin PGE1 in tissue culture medium 199 for 7 hr caused a % increase in the release of labeled growth hormone into the incubation medium. PGE1 at 10-8 M increased growth hormone synthesis but not release. At 10-6 M, PGE2 had effects similar to PGE1; PGA1 increased growth hormone synthesis- but not release. PGF2a was without effect on either synthesis or release of growth hormone. Prolactin synthesis and release were not affected by prostaglandins. All of the prostaglandins, at 10-4 M, increased adenyl cyclase activity in the pituitary gland but phosphodiesterase activity was unaltered. Dibutyryl cyclic AMP, with or without caffeine, caused an up to 300% increase in labeled growth hormone release. No consistent effect of prolactin was observed. If potassium concentration was increased 10-fold, a 215% increase in growth hormone release was observed. A combination of hypertonic potassium and 10-6 M PGE1 increased growth hormone release 325%, suggesting that potassium and prostaglandins act by independent mechanisms. Addition of theophylline to pituitary gland, incubated in vitro, increased both the synthesis and release of growth hormone. Although fluoride greatly stimulated growth hormone release, it completely inhibited the incorporation of leucine into the hormone. Similarly, puromycin inhibited synthesis of growth hormone but did not block release induced by prostaglandin, dibutyryl cyclic AMP, theophylline, or fluoride. Prostaglandins increase pituitary adenyl cyclase activity and, presumably via cyclic AMP, increase growth hormone release, independently of protein synthesis. Hormonal secretions of the anterior pituitary gland are thought to be regulated by agents released by the hypothalamus into the hypophyseal portal blood vessels leading to the gland.1 The agents or neurohormones that control growth hormone synthesis are not well characterized2 and very little is known about the mechanism by which they affect release of the hormone. The rapidity with which neurohormones cause growth hormone release suggests that stored hormone is discharged from the cell and may directly or indirectly stimulate the synthesis of new hormone. Neurohormones have been shown to affect the 1172
2 VOL. 67, 1970 PROSTAGLANDINS AND HORMONE RELEASE 1173 pituitary gland, steroidogenesis in the adrenal gland35, lipolysis, and adipose tissue.6 7 These processes are influenced by cyclic AMP generated in the tissues by specific hormones. Prostaglandins, among other substances present in the hypothalamus, alter the intracellular level of cyclic AMP in other tissues.8'9 Materials and Methods. Mature female ( g) and male ( g) Sprague- Dawley rats were obtained from Flow Research Animals, Dublin, Va. Prostaglandins El, E2, F2,, and Al were gifts of Dr. John E. Pike of the Upjohn Co. Incorporation of [4,5-8H]leucine into prolactin and growth hormone was studied by incubating bisected pituitary glands in 0.5 or 1.4 ml of tissue culture Medium 199 containing 5-10,Ci of the isotope. Flasks were incubated for 7 hr at 370C in a Dubnoff shaker under 95% 02-5% CO2. Pituitary glands were homogenized in 0.5 ml of 50 mm phosphate (ph 7.2) with a glass homogenizer fitted with a Teflon pestle. Homogenates were frozen and thawed three times to lyse all granules. Duplicate aliquots (50,ul) were then electrophoresed on polyacrylamide gell 0" with the sample, stacking, and separating gel system of Jones et al.12 The incubation medium was separated on gels but the 50- ;41 aliquots were "top-loaded" using the system described by Reisfeld et al."3 The proteins on the gels were stained with amido black, and quantitated by means of a Canalco microdensitometer with an integrator. The patterns produced by the rat pituitary hormones were identified by comparing their mobility with purified preparations of prolactin and growth hormone. Our results are in excellent agreement with Jones et al.2, who eluted these proteins from the polyacrylamide gels and established their identity by bioassay. Adenyl cyclase activity was determined by the method of Zor et al.,'4 protein by the method of Lowry et al.15 Cyclic AMP phosphodiesterase activity was assayed by the method of Butcher and Sutherland.'6 Results. The effect of prostaglandin PGE1 on the incorporation of [4,5-3H]- leucine into growth hormone in vitro is presented in Fig. 1. The addition of 10- M PGE, increased the growth hormone released into the incubation medium 165%; normal amounts of the hormone were maintained within the pituitary gland. At a concentration of 10-7 iv PGE1, labeled growth hormone 2400 Pituitary Gland Incubation Medium Total 240 ax 1400, ~100c Control Control i-8 Control o-8 Molar concentration of prostaglandin PGE1 FIG. 1. Effect of prostaglandin PGE, on the incorporation of [4,5-3H]leucine into growth hormone. Four hemi-anterior pituitary glands were incubated in four flasks containing 1.4 ml of tissue culture medium 199, 10 MCi of [4,5-3H]leucine, and prostaglandin for 7 hr at 370C; 3 flasks/group.
3 1174 BIOCHEMISTRY: MAcLEOD AND LEHMEYER PROC. N. A. S. in the medium increased 40%, and only slightly within the tissue. Although growth hormone release was inhibited by \1 PGE1, the synthesis of the hormone in the gland increased. The data presented in Table 1 show that PGE1 and PGE2 increased the release TABLE 1. Effect of various prostaglandtns on the incorporation of [4,5-H]leucine into growth hormone. Absorbance Radioactivity units per No. of.- (cpm/mg pituitary)--- mg pituitary deter- Pituitary Incubation Incubation Prostaglandin minations gland medium medium Control i PGE, 10-' M i 37* 25.3t PGE M t 557 =1 48t 25.6t PGA10O-M * 370± PGF?, 10-6 M ± ±A Values are means ±t SE. * P < 0.01; t P < 0.05 with respect to control value. of newly synthesized hormone 44%, while causing a slight decrease in labeled hormone within the gland. Although PGA1 did not cause the release of labeled growth hormone into the incubation medium, it significantly increased the incorporation of radioactive leucine into the pituitary growth hormone. PGF2< did not increase growth hormone synthesis or release. M1icrodensitometric determinations showed that only PGE1 and PGE2 increased hormone release. Since prostaglandins influence the cyclic AMP concentration in certain tissues, we determined whether adenyl cyclase activity in the pituitary gland was affected by prostaglandins. Table 2 shows that the addition of PGE1, PGA1, and PGF2< increased adenyl cyclase activity in the anterior pituitary gland. TABLE 2. Effect of prostaglandins on the formation of cyclic ['2P]AMP from [a-32p]atp in anterior pituitary glands. Picomoles cyclic [32P]AMP per gland per 60 m in Control PGE, PGF2a PGA, Expt ± ±t 0.04* Expt ± ±t 2.60t 8.03 ± 1.87t The prostaglandin (6 pg) was incubated 60 min at 37 C with a whole anterior pituitary gland in 40 mm Tris HCl (ph 7.8) containing 3.5mM Mg2 +, 10 mm theophylline, 0.15 mg albumin, 20 mm ATP, 1 uci [a82p]atp, 1.3 mm cyclic AMP, 7 mm PEP, and 4,units pyruvate kinase in a volume of 0.15 ml. The cyclic 132P]AMP was isolated by thin-layer chromatography (Expt. 1) or by separation on a Dowex 50 column (Expt. 2). PEP, phosphoenolpyruvate. * P < 0.005; t P < Incubation of pituitary glands for 2 hr with 10-5 M PGE1 in tissue culture medium 199 had no effect on phosphodiesterase activity. Many attempts to show that the sodium salt of cyclic AMP, in the absence of caffeine, influenced growth hormone synthesis were unsuccessful. The results presented in Table 3 show that dibutyryl cyclic AMP caused a consistent increase in growth hormone release: 5 mm produced increases of 220 and 250% and 0.1 mm produced a 180% increase in newly synthesized growth hormone. The fact that radioactive growth hormone did not accumulate within the gland in the
4 VOL. 67, 1970 PROSTAGLANDINS AND HORMONE RELEASE 1175 TABLE 3. Effect of dibutyryl cyclic AMP on the incorporation of [4,5-3H]leucine into prolactin and growth hormone. Absorbance Radioactivity units GH (cpm/mg pituitary) per mg Prolactin I - Growth hormone--_ pituitary Pituitary Incubation Pituitary Incubation Incubation gland medium gland medium medium Control 154 i :1: i i Dibutyryl cyclic AMP 0.1 mm 157 i ± i i: 201* 19.9 Dibutyryl cyclic AMP5mM 96 4± ± ± 18* 2221 i 111* 22.1 Each group comprised of four flasks containing four pituitary gland halves from male rats, 1.4 ml of medium 199, and 10 uci [4,53H]leucine; incubated 7 hr. *P <.01. presence of dibutyryl cyclic AMP is taken to indicate that the cyclic nucleotide was acting primarily on growth hormone release and not on its synthesis. No consistent effect of dibutyryl cyclic AMP on prolactin release was observed. The data in Table 4 give additional evidence that cyclic AMP acts primarily TABLE 4. Effect of theophylline and NaF on the synthesis and release of growth hormone and prolactin. Radioactivity Absorbance (cpm/mg pituitary) - units per '_ ~Prolactin _- - Growth hormone - mg pituitary Pituitary Medium Pituitary Medium Medium Control ± ± ± ±t 0.9 Theophylline 10 mm ± ± ±- 102* 38.9 ±4 3.9* NaF 10 mm... 7 ± 2 76 ± 5 65 ±t 6* 37.0 ± 6.1* Single pituitary glands were incubated in 0.5 ml of medium 199 containing 5 ACi of [4,5-3H]leucine. Values are means 4 SE. *P < on release of the hormone. Theophylline, an inhibitor of phosphodiesterase, produced a significant increase in growth hormone release measured by microdensitometric and by isotopic methods. NaF greatly increased growth hormone release but completely inhibited the synthesis of growth hormone. The effects of theophylline and fluoride on growth hormone synthesis and release are presented in Fig. 2. NaF at 10-2 M increased release 130% but almost completely inhibited the incorporation of leucine into growth hormone. Lower concentrations of fluoride were less effective in stimulating release of growth hormone and inhibiting hormone synthesis. Theophylline increased growth hormone release 130, 170, and 60% when pituitary glands were incubated in the presence of 10-2, 10-3, or 10-4 M theophylline; synthesis was stimulated by 65, 110, or 15%. Table 5 shows that theophylline, PGE1, and dibutyryl cyclic AMP increased the incorporation of leucine into growth hormone; increased the total amount of growth hormone released into the incubation medium; and decreased the amount remaining in the gland. The addition of pyromycin to flasks containing these substances inhibited the incorporation of leucine into growth hormone but did
5 1176 BIOCHEMISTRY: MAcLEOD AND LEHMEYER PROC. N. A. S. C X "30 a: 2~~~~~~~~~~~~~~ O -20 c 0 T I 50/ -10 Or ' L cc~~~~~~~~~~~~~~ M SODIUM FLUORIDE M THEOPHYLLINE FIG. 2. Effect of various concentrations of NaF and theophylline on the synthesis and release of growth hormone. Two hemi-anterior pituitary glands were incubated as described in Fig. 1 in six flasks containing 0.5 ml of tissue culture medium 199, 5,uCi of [4,5-3H]leucine, and the indicated amounts of NaF or theophylline. The solid lines refer to the absorbance units of growth hormone in the incubation medium and the dashed lines refer to the radioactive growth hormone in the incubation medium. The shaded bars refer to the mean i SE of control flasks; 3 flasks/group. not inhibit release of the hormone. Additionally, puromycin did not inhibit the fluoride-induced increase in growth hormone release. When potassium concentration was made hypertonic, growth hormone release was significantly increased.'7 Fig. 3 shows that the addition of 10-6 M PGE1 to Medium 199 increased growth hormone in the incubation medium 175%; also that increasing the potassium concentration 10-fold, to 59.4 mm, caused a 215% increase in hormone release. The combination of increased potassium concen- TABLE 5. Effect of puromycin on the synthesis and release of growth hormone. Incorporation of [4,5-3H]leucine Absorbance (cpm/mg) -~ - (units/mg) Pituitary Incubation Pituitary Incubation gland medium gland medium Control i i :1 3.3 Puromycin 0.2 mm 21 i 5 27 i Theophylline 10 mm 4161 i Theophylline + puromycin 9± PGE, 1 IM i PGE, + puromycin 8 i 3 12 i Dibutyryl cyclic AMP 1 mm 2595 i i Dibutyryl cyclic AMP + puromycin ± NaF 10 mm 61 +t NaF + puromycin Two halves of bisected pituitary glands were incubated in 0.5 ml of Medium 199 containing 5 jsci of H]leucine, the indicated compound, and/or puromycin for 7 hr.
6 VOL. 67, 1970 PROSTAGLANDINS AND HORMONE RELEASE FIG. 3. Effect of pros taglandins and cations on III the incorporation of [4, pituitary 3H]leucine into growth hor- TuitaryP mone. Four hemi-anterior pituitary glands were incubated using conditions described in Fig. 1 except that some flasks contained 10 times as much K+ or Ca++ as 60* medium in the control medium; 3 flasks/group. Ordinate is cpm/mg pituitary Control PGE1 K+ PGE1 Ca`+ PGE1 K+ PGE1 K+ Ca++ Ca++ K+ Ca++ tration and prostaglandin increased growth hormone release 325%. Calcium, 5.1 mm, had no effect on growth hormone release in the presence or absence of prostaglandin, although the addition of Ca2+ at elevated K+ and PGE1 concentrations increased radioactive growth hormone released into the medium 395%. PGE1 had no significant affect on total growth hormone synthesis, nor did its addition influence the potentiating affect of K+ on hormone synthesis. The incorporation of [4,5-3H]leucine into growth hormone was reduced in potassium-free incubation medium (Table 6); however, the addition of \1 PGE1 to buffer with or without K+ increased growth hormone release. TABLE 6. Effect of potassium ion on the prostaglandin-induced increase of growth hormone synthesis and release. Radioactivity Absorbance units _ ~~(cpm/mg pituitary) - per mg pituitary Pituitary Incubation Incubation Buffer gland medium medium Complete KRB KRB minus K Complete KRB with PGE i * 25.9* KRB minus K+ with PGE ± 99* 314 ± 13* 27.6* Pituitary glands from female rats were incubated in Krebs-Ringer bicarbotmite buffer containing 1.8 mg/ml glucose, a complete essential and nonessential amino acid mixture (Microbiological Associates), and 10 fci of [4,5-3H]leucine for 7 hr at 370C. Prostaglandin PGE1, 10-6 M. Values are means ± SE. *P <.01 Discussion. The ubiquitous distribution of prostaglandins and their many effects on tissues were discussed by Bergstr6m et al.9, but it has only recently been demonstrated that endocrine function is influenced by these substances. The in vivo injection of PGE1 and PGE2, but not P'GFia nor PGF2a, stimulated ACTH release."8"19 Flack28 showed that corticosteroidogenesis is increased by prostaglandin in vitro. In thyroid slices, PGE increased proteolysis2' and the levels of cyclic A'IiP in thyroid,22 lung, spleen, diaphragm and whole fat pads.7 Zor et al.'4 showed that adenyl cyclase activity was increased in rat pituitary glands after prostaglandin addition, and resulted in increased levels of cyclic AMP.
7 1178 BIOCHEMISTRY: MAcLEOD AND LEHMEYER PROC. N. A. S. We confirm the findings of Zor et al.14 and show that PGE1, PGE2, and PGA1 increase adenyl cyclase activity in the anterior pituitary gland. The release of growth hormone was significantly increased by prostaglandins PGE1 and PGE2 but not by PGA1 or PGF2a. A possible physiological function for the prostaglandins is suggested by the finding that the dibutyryl ester of cyclic AMP greatly increased growth hormone but not prolactin release. TSH23 and ACTH24 have also been shown to be released by dibutyryl cyclic AMP. Prostaglandins apparently have some degree of specificity with regard to pituitary hormone release because prolactin and luteinizing hormone26 are not affected by these agents. Since prostaglandins increase adenyl cyclase activity in the pituitary gland, the cyclic nucleotide produced may increase the release of ACTH, TSH, and GH. Substances that are capable of affecting adenyl cyclase or phosphodiesterase activity in the pituitary also alter hormone release. The in vitro addition of theophylline increased GH release, a result previously found in Vivo.26 Additionally, NaF, an activator of adenyl cyclase but also an inhibitor of glycolysis, produced a large increase in GH release but completely inhibited the incorporation of leucine into the hormone. This is evidence that fluoride was affecting the release of growth hormone directly and not the synthesis of new molecules of growth hormone, and that, since NaF inhibits energy derivation from the glycolytic metabolism of glucose, the release of growth hormone is a minimal- or nonenergy dependent process. That synthesis of new growth hormone is not requisite for release of the hormone has been conclusively demonstrated by the findings that puromycin completely inhibited the synthesis of growth hormone without interfering with the increase in growth hormone release induced by prostaglandin, cyclic AMP, theophylline, or fluoride. The release of luteinizing hormone was not dependent upon synthesis of the hormone,27 nor was release of TSH.28'29 Subsequent to the drug-induced decrease in pituitary growth hormone concentration, an increase in hormone synthesis occurred. Although the mechanisms governing the synthesis of growth hormone are poorly understood, we would speculate that the pituitary gland is capable of detecting a decrease in growth hormone content in cells in which the hormone is synthesized, resulting in a compensatory increase in the synthesis of hormone. Previously, we reported on the selective effects of various ions on growth hormone and prolactin release. 17 Hypertonic amounts of potassium released growth hormone but did not affect prolactin. Conversely, calcium increased prolactin release but had no affect on growth hormone release. Although prostaglandins are known to increase cation flux in several tissues,-3io, the current data show that the incubation of pituitary glands, in media hypertonic with respect to potassium and/or calcium, with prostaglandin PGE1 increased growth hormone release to a greater extent than did PGE1 or the cations separately. These substances probably act independently to release growth hormone. The addition of epinephrine in vitro to several tissues increased adenyl cyclase activity;32-35 however, it has no affect on this enzyme in pituitary tissue. It is probable that catecholamines inhibit prolactin release and synthesis36 by a
8 VOL. 67, 1970 PROSTAGLANDINS AND HORMONE RELEASE 1179 mechanism other than that involving cyclic AMP. Prostaglandins and dibutyryl cyclic AMP also did not consistently affect prolactin release. Although the data suggest that any substance that was functionally capable of increasing the cyclic AMP level would also cause growth hormone release, it should be noted that, whereas all prostaglandins tested increased adenyl cyclase activity, only PGE1 and PGE2 increased growth hormone release. We cannot explain this finding at present. We acknowledge the significant collaboration of Ronald C. Pace, Joseph Gascho, and Elizabeth Fontham. The work was supported by grant CA from the National Cancer Institute. R. M. M. is United States Public Health Service Research Career Development Awardee CA l McCann, S. M., and J. C. Porter, Physiol. Revs., 49, 240 (1969). 2Schally, A. V., E. E. Mfiller, A. Arimura, T. S. Sawano, and C. Y. Bowers, Ann. N.Y. Acad. Si., 148, 372 (1968). 3Haynes, R. L., E. W. Sutherland, and T. W. Rall, Recent Progr. Horm. Res., 16, 121 (1960). 4Karaboyas, G. C., and S. B. Koritz, Biochemistry, 4, 462 (1965). 5 Graham-Smith, D. G., R. W. Butcher, R. L. Ney, and E. W. Sutherland, J. Biol. Chem., 242, 5535 (1967). 6Klainer, L. M., Y. M. Chi, S. L. Freidberg, T. W. Rall, and E. W. Sutherland, J. Biol. Chem., 237, 1239 (1962). 7Butcher, R. W., and C. E. Baird, J. Biol. Chem., 243, 1713 (1968). 8 Butcher, R. W., and E. W. Sutherland, Ann N.Y. Acad. Sci., 139, 849 (1967). 9 Bergstrom, S., Science, 157, 382 (1967). '0MacLeod, R. M., M. C. Smith, and D. W. DeWitt, Endocrinology, 79, 1149 (1966). 1MacLeod, R. M., and A. Abad, Endocrinology, 83, 799 (1968). 12 Jones, A. E., J. N. Fisher, U. J. Lewis, and W. P. VanderLaan, Endocrinology, 76, 578 (1965). 13 Reisfeld, R. A., U. J. Lewis, and D. E. Williams, Nature, 195, 578 (1965). 14Zor, U., T. Kaneko, H. P. G. Schneider, S. M. McCann, I. P. Lowe, G. Bloom, B. Borlan, and J. B. Field, Proc. Nat. Acad. Sci. USA, 63, 918 (1969). 1" Lowry, 0. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall, J. Biol. Chem., 193, 265 (1951). 6 Butcher, R. W., and E. W. Sutherland, J. Biol. Chem., 237, 1244 (1962). 17 MacLeod, R. M., Endocrinology, 86, 863 (1970). 18 de Wied, D., A. Witter, D. H. G. Versteeg, and A. H. Mulder, Endocrinology, 85, 561 (1969). 19 Peng, T. C., K. M. Six, and P. L. Munson, Endocrinology, 86, 202 (1970). 20 Flack, J. D., Science, 163, 691 (1969). 21 Ahn, C. S., and I. N. Rosenberg, Endocrinology, 86, 870 (1970). 22 Kaneko, T., U. Zor, and J. B. Field, Science, 163, 1062 (1969). 23 Wilber, J. F., G. T. Peake, and R. D. Utiger, Endocrinology, 84, 758 (1969). 24Fleischer, N., F. A. Donald, and R. W. Butcher, Amer. J. Physiol., 217, 1287 (1969). 25Zor, U., T. Kaneko, H. P. G. Schneider, S. M. McCann, and J. B. Field, J. Biol. Chem., 245, 2883 (1970). 26 Schofield, J. G., Nature, 215, 1382 (1967). 27 Samli, M. H., and I. I. Geschwind, Endocrinology, 82, 225 (1968). 28Wilber, J. F., and R. D. Utiger, Proc. Soc. Exp. Biol. Med., 127, 488 (1968). 29 Vale, W., R. Burfus, and R. Guillemin, Neuroendocrinology, 3, 34 (1968). 30 Vergoesen, A. J., and J. De Boer, Eur. J. Pharmacol., 3, 171 (1968). 31 Wooster, M. J., and I. H. Mills, 3rd Int. Congr. Endocr, Mexico City, June 30-July 5, 1968, Excerpta Medica Foundation (Amsterdam, 1968), pp Bar, H.-P., and 0. Hechter, Proc. Nat. Acad. Sci. USA, 63, 350 (1969). 83 Birnbaumer, L., S. L. Pohl, and M. Rodbell, J. Biol. Chem., 244, 3468 (1969). 34Klainer, L. M., Y. M. Chi, S. L. Freidberg, T. W. Rall, and E. W. Sutherland, J. Biol. Chem., 237, 1239 (1962). 35 Murad, F., Y. M. Chi, T. W. Rall, and E. W. Sutherland, J. Biol. Chem., 237, 1233 (1962). 36 MacLeod, R. M., Endocrinology, 85, 916 (1969).
COLLOID DROPLET FORMATION IN DOG THYROID IN VITRO
COLLOID DROPLET FORMATION IN DOG THYROID IN VITRO Induction by Dibutyryl Cyclic-AMP I. PASTAN and S. HI. WOLLMAN. Froml the National Institute of Arthritis and Metabolic Diseases and the National Cancer
More informationSynopsis. Received March 2, adrenaline. Mosinger and Kujalova (1964) reported that adrenaline-induced lipolysis
Studies on Reduction of Lipolysis in Adipose Tissue on Freezing and Thawing YASUSHI SAITO1, NoBUO MATSUOKA1, AKIRA KUMAGAI1, HIROMICHI OKUDA2, AND SETSURO FUJII3 Chiba University, Chiba 280, Japan, 2Department
More informationGlucocorticoid Regulation of ACTH Sensitivity of
Proceedings of the National Academy of Sciences Vol. 66, No. 3, pp. 995-1001, July 1970 Glucocorticoid Regulation of ACTH Sensitivity of Adenyl Cyclase in Rat Fat Cell Membranes T. Braun* and 0. Hechter
More informationGENERAL CHARACTERISTICS OF THE ENDOCRINE SYSTEM FIGURE 17.1
GENERAL CHARACTERISTICS OF THE ENDOCRINE SYSTEM FIGURE 17.1 1. The endocrine system consists of glands that secrete chemical signals, called hormones, into the blood. In addition, other organs and cells
More informationMonday, 7 th of July 2008 ( ) University of Buea MED30. (GENERAL ENDOCRINOLOGY) Exam ( )
.. Monday, 7 th of July 2008 (8 30-11. 30 ) Faculty of Health Sciences University of Buea MED30 304 Programme in Medicine (GENERAL ENDOCRINOLOGY) Exam (2007-2008).. Multiple Choice Identify the letter
More informationBIOL 2458 A&P II CHAPTER 18 SI Both the system and the endocrine system affect all body cells.
BIOL 2458 A&P II CHAPTER 18 SI 1 1. Both the system and the endocrine system affect all body cells. 2. Affect on target cells by the system is slow. Affect on target cells by the system is fast. INTERCELLULAR
More informationEvidence for separate receptors for melanophore stimulating hormone and catecholamine regulation of cyclic AMP in the control of melanophore responses
Br. J. Pharmac. (1970), 39, 160-166. Evidence for separate receptors for melanophore stimulating hormone and catecholamine regulation of cyclic AMP in the control of melanophore responses J. M. GOLDMAN
More informationThe Endocrine System. Hormone =
The Endocrine System Hormone = Types: peptide or protein = at least 3 amino acids steroid = derived from cholesterol amine = derived from single amino acids (tryptophan, tyrosine) Peptide Hormones Synthesis/transport/half-life
More informationThe Endocrine System. The Endocrine System
The Endocrine System Like nervous system, endocrine system provides communication and control. Messages are relayed from one cell to another via chemical messengers (hormones). Unlike nervous system which
More informationChapter 11 - Endocrine System
Chapter 11 - Endocrine System 11.1 Introduction A. The endocrine system is made up of the cells, tissues, and organs that secrete hormones into body fluids. B. The body has two kinds of glands, exocrine
More informationBinding of Thyrotropin-Releasing Hormone to Plasma Membranes of Bovine Anterior Pituitary Gland
Proc. Nat. Acad. Sci. USA Vol. 69, No. 1, pp. 283-287, January 1972 Binding of Thyrotropin-Releasing Hormone to Plasma Membranes of Bovine Anterior Pituitary Gland (hormone receptor/adenylate cyclase/equilibrium
More informationCyclic AMP-Mediated Induction of the Cyclic AMP Phosphodiesterase
Proc. Nat. Acad. Sci. USA Vol. 71, No. 1, pp. 3844-3848, October 1974 Cyclic AMP-Mediated nduction of the Cyclic AMP Phosphodiesterase of C-6 Glioma Cells (dibutyryl cyclic AMP/norepinephrine/norepinephrine
More informationhuman anatomy & physiology sampler questions
human anatomy & physiology sampler questions Please note that there are questions within this set that test material that may not have been covered in your lecture; unless otherwise specified, lecture
More informationhyperpolarization (4-6 mv). The effect of isoprenaline, but not that of hyperpolarization of 4-8 mv.
J. Physiol. (1974), 239, pp. 647-656 647 With 4 text-figures Printed in Great Britain THE EFFECT OF GLUCAGON ON THE LIVER CELL MEMBRANE POTENTIAL BY 0. H. PETERSEN From the Institute of Medical Physiology
More informationChapter 11. Endocrine System
Chapter 11 Endocrine System 1 Introduction A. The endocrine system is made up of the cells, tissues, and organs that secrete hormones into body fluids. B. Hormones diffuse into the bloodstream to act target
More informationKinetic studies on insulin inhibition of fat cell adenylyl cyclase
Arch. Biol. Med. Exper. 72:399-405,1979 Kinetic studies on insulin inhibition of fat cell adenylyl cyclase Estudios cinéticos de la inhibición por insulina de la adenilil ciclasa de células adiposas HECTOR
More informationArt labeling Activity: Figure 16.1
ANP 1105D Winter 2013 Assignment 6 part I: The Endocrine Sy... Assignment 6 part I: The Endocrine System, Chapter 16 Due: 11:59pm on Monday, March 4, 2013 Note: To understand how points are awarded, read
More informationChapter 16 - Endocrine system
Chapter 16 - Endocrine system I. Overview Nervous control is fast but short-lived Hormonal control is slow and lasts a long time A. Organs: hypothalamus, pituitary (hypophysis), thyroid, parathyroid, adrenal,
More informationEndocrine System Hormones. AP Biology
Endocrine System Hormones 2007-2008 Regulation Why are hormones needed? u chemical messages from one body part to another u communication needed to coordinate whole body u daily homeostasis & regulation
More informationEndocrine System. Always willing to lend a helping gland
Endocrine System Always willing to lend a helping gland Functions of the Endocrine System Regulates metabolic activities through hormones Controls reproduction, growth and development, cellular metabolism,
More informationHuman Biochemistry. Hormones
Human Biochemistry Hormones THE ENDOCRINE SYSTEM THE ENDOCRINE SYSTEM THE ENDOCRINE SYSTEM The ENDOCRINE SYSTEM = the organ system that regulates internal environment conditions by secreting hormones into
More informationBIOLOGY - CLUTCH CH.45 - ENDOCRINE SYSTEM.
!! www.clutchprep.com Chemical signals allow cells to communicate with each other Pheromones chemical signals released to the environment to communicate with other organisms Autocrine signaling self-signaling,
More informationTHE ROLE OF 5-HYDROXYTRYPTAMINE AND CYCLIC AMP IN THE CONTROL OF FLUID SECRETION BY ISOLATED SALIVARY GLANDS
J. Exp. Biol. (1970), 53, 171-186 With 14 text-figures Printed in Great Britain THE ROLE OF 5-HYDROXYTRYPTAMINE AND CYCLIC AMP IN THE CONTROL OF FLUID SECRETION BY ISOLATED SALIVARY GLANDS BY M. J. BERRIDGE
More informationENDOCRINOLOGY COORDINATION OF PHYSIOLOGICAL PROCESSES:
ENDOCRINOLOGY COORDINATION OF PHYSIOLOGICAL PROCESSES: -In a living organism there must be coordination of number of physiological activities taking place simultaneously such as: movement, respiration,
More informationThe Endocrine System. I. Overview of the Endocrine System. II. Three Families of Hormones. III. Hormone Receptors. IV. Classes of Hormone Receptor
The Endocrine System I. Overview of the Endocrine System A. Regulates long term metabolic processes B. Releases hormones from endocrine cells 1. Hormones are chemicals 2. Alter metabolism of cells 3. Release
More informationStimulation by Dopamine of Adenylate Cyclase in Retinal Homogenates and of Adenosine-3':5'-Cyclic Monophosphate Formation in Intact Retina
Proc. Nat. Acad. Sci. USA Vol. 69, No. 3, pp. 539-543, March 1972 Stimulation by Dopamine of Adenylate Cyclase in Retinal Homogenates and of Adenosine-3':5'-Cyclic Monophosphate Formation in Intact Retina
More informationEndocrine System Hormones (Ch. 45)
Endocrine System Hormones (Ch. 45) Regulation Why are hormones needed? chemical messages from one body part to another communication needed to coordinate whole body daily homeostasis & regulation of large
More informationChapter 18: Endocrine Glands
Chapter 18: Endocrine Glands I. Functions of the Endocrine System A. List and describe the eight major functions of the endocrine system: 1. 2. 3. 4. 5. 6. 7. 8. Page 1 of 19 C II. Pituitary Gland and
More informationChapter 16: Endocrine System 1
Ch 16 Endocrine System Bi 233 Endocrine system Endocrine System: Overview Body s second great controlling system Influences metabolic activities of cells by means of hormones Slow signaling Endocrine glands
More informationModel Answer. M.Sc. Zoology (First Semester) Examination Paper LZT 103 (Endocrinology)
Model Answer M.Sc. Zoology (First Semester) Examination-2013 Paper LZT 103 (Endocrinology) Section A 1. (i) d (ii) b (iii) b (iv) c (v) c (vi) a (vii) c (viii) a (ix) d (x) b Section B Q.2 Answer Hormonal
More informationEndocrine system. General principle of endocrinology. Mode of hormone delivery to target. Mode of hormone delivery to target
Endocrine system General principle of endocrinology Co-ordinating system to regulate and integrate function of different cells - Nervous system -Endocrine system Neuro-endocrine system Hormone Molecules
More informationGeneral Principles of Endocrine Physiology
General Principles of Endocrine Physiology By Dr. Isabel S.S. Hwang Department of Physiology Faculty of Medicine University of Hong Kong The major human endocrine glands Endocrine glands and hormones
More informationExercise Physiology: Theory and Application to Fitness and Performance By Scott Powers & Edward Howley
Exercise Physiology: Theory and Application to Fitness and Performance By Scott Powers & Edward Howley Ch 5 Cell Signaling and the Hormonal Responses to Exercise Summary Created by Dan Hechler Class Lecture
More informationEndocrine Notes Mrs. Laux AP Biology I. Endocrine System consists of endocrine glands (ductless), cells, tissues secrete hormones
I. Endocrine System consists of endocrine glands (ductless), cells, tissues secrete hormones regulates metabolism, fluid balance, growth, reproduction A. Hormones 1. chemical signals-cell to cell communication
More informationAdipose Tissue * MARTHA VAUGHAN. after the intravenous administration of T5 to thyroidectomized
The Journal of Clinical Investigation Vol. 46, No. 9, 1967 An In Vitro Effect of Triiodothyronine on Rat Adipose Tissue * MARTHA VAUGHAN (From the Laboratory of Metabolism, National Heart Institute, National
More information4/23/2018. Endocrine System: Overview. Endocrine System: Overview
Endocrine System: Overview With nervous system, coordinates and integrates activity of body cells Influences metabolic activities via hormones transported in blood Response slower but longer lasting than
More informationEndocrine secretion cells secrete substances into the extracellular fluid
Animal Hormones Concept 30.1 Hormones Are Chemical Messengers Endocrine secretion cells secrete substances into the extracellular fluid Exocrine secretion cells secrete substances into a duct or a body
More informationChapter 9. The Endocrine System. Lecture Presentation by Patty Bostwick-Taylor Florence-Darlington Technical College Pearson Education, Inc.
Chapter 9 The Endocrine System Lecture Presentation by Patty Bostwick-Taylor Florence-Darlington Technical College Intro to the Endocrine System Chief Complaint:8-year-old girl with excessive thirst, frequent
More informationENDOCRINOLOGY. Dr.AZZA SAJID ALKINANY 2 nd STAGE
ENDOCRINOLOGY Dr.AZZA SAJID ALKINANY 2 nd STAGE THE RELATIONSHIP AMONG THE HYPOTHALMUS,POSTERIOR PITUITARY AND TARGET TISSUES. The posterior pituitary does not produce its own hormones, but stores and
More information2) Storehouse for the hormones produced by the hypothalamus of the brain. 2)
AP 2 Exam Chapter 16 Endocrie Due Wed. night 4/22 or Thurs. morning 4/23 Name: Matching; match the labeled organ with the most appropriate response or identification. Figure 16.1 Using Figure 16.1, match
More informationStimulation of Thyroid Metabolism by Thyrotropin, Cyclic 3 : 5 -AMP, Dibutyryl Cyclic 3 : 5 -AMP and Prostaglandin E,
European J. Biochem. 8 (1969) 26-32 Stimulation of Thyroid Metabolism by Thyrotropin, Cyclic 3 : 5 -AMP, Dibutyryl Cyclic 3 : 5 -AMP and Prostaglandin E, F. RODESCH, P. NEVE, C. WILLEMS, and J. E. DUMONT
More informationBIOLOGY 2402 Anatomy and Physiology Lecture. Chapter 18 ENDOCRINE GLANDS
BIOLOGY 2402 Anatomy and Physiology Lecture Chapter 18 ENDOCRINE GLANDS 1 ENDOCRINE GLANDS Homeostasis depends on the precise regulation of the organs and organ systems of the body. Together the nervous
More informationCATEGORY Endocrine System Review. Provide labels for the following diagram CHAPTER 13 BLM
CHAPTER 13 BLM 13.1.1 CATEGORY Endocrine System Review Provide labels for the following diagram. 1. 6. 2. 7. 3. 8. 4. 9. 5. 10. CHAPTER 13 BLM 13.1.2 OVERHEAD Glands and Their Secretions Endocrine gland
More informationCyclic Adenosine 3,5'-Monophosphate in
Cyclic Adenosine 3,5'-Monophosphate in Human Lymphocytes. Alterations after Phytohemagglutinin Stimulation JAY W. SMITH, ALTON L. STEINER, W. MARCUs NEWBERRY, JR., and CHARLES W. PARKER From the Washington
More informationThe Endocrine System PART A
9 The Endocrine System PART A PowerPoint Lecture Slide Presentation by Jerry L. Cook, Sam Houston University ESSENTIALS OF HUMAN ANATOMY & PHYSIOLOGY EIGHTH EDITION ELAINE N. MARIEB The Endocrine System
More informationHORMONES AND CELL SIGNALLING
HORMONES AND CELL SIGNALLING TYPES OF CELL JUNCTIONS CHEMICAL SIGNALS AND MODES OF ACTION Endocrine system produces chemical messages = hormones that are transported from endocrine gland to target cell
More informationCellular Messengers. Intracellular Communication
Cellular Messengers Intracellular Communication Most common cellular communication is done through extracellular chemical messengers: Ligands Specific in function 1. Paracrines Local messengers (neighboring
More informationMedical Endocrinology / Introduction 4 Medical Endocrinology
Medical Endocrinology / Introduction 4 Medical Endocrinology 1 2 : Positive feedback control of labor contractions during birth of a baby. The solid return arrow symbolizes positive feedback. If the response
More informationPARALLEL REGULATION OF CYCLIC AMP-DEPENDENT PROTEIN KINASE AND PHOSPHOPROTEIN PHOSPHATASE IN RAT THYROID
Volume 99, number I FEBS LETTERS March 1979 PARALLEL REGULATION OF CYCLIC AMP-DEPENDENT PROTEIN KINASE AND PHOSPHOPROTEIN PHOSPHATASE IN RAT THYROID Shankar HUPRIKAR, Michael LANG, Yochanan FRIEDMAN and
More informationHormones and the Endocrine System Chapter 45. Intercellular communication. Paracrine and Autocrine Signaling. Signaling by local regulators 11/26/2017
Hormones and the Endocrine System Chapter 45 Intercellular communication Endocrine signaling Local regulators Paracrine and autocrine signaling Neuron signaling Synaptic and neuroendocrine signaling Paracrine
More informationTestosterone and other male hormones seem to be related to aggressive behavior in some species
Testosterone and Male Aggression Testosterone and other male hormones seem to be related to aggressive behavior in some species In the fish species Oreochromis mossambicus, elevated levels have been found
More informationBIO 116 Practice Assignment 1 The Endocrine System and Blood This is not a required assignment but it is recommended.
BIO 116 Practice Assignment 1 The Endocrine System and Blood This is not a required assignment but it is recommended. 1. Match the following glands of the endocrine system with the appropriate label 1.
More informationEndocrine System. Endocrine vs. Exocrine. Bio 250 Human Anatomy & Physiology
Endocrine System Bio 250 Human Anatomy & Physiology Endocrine vs. Exocrine Endocrine glands secrete their products called hormones into body fluids (the internal environment) Exocrine glands secrete their
More informationBiology 2100 Human Physiology C. Iltis SLCC March 8, Midterm Examination #2
Biology 2100 Human Physiology Name: KEY C. Iltis SLCC March 8, 2000 Midterm Examination #2 Multiple Choice Questions (2 POINTS EACH) 1. When glucose levels are above 100 mg/dl, which of the following is
More informationEndocrine System Notes
Endocrine System Notes is the tendency to maintain a stable internal environment. - parts of the body that secrete hormones directly into the body. - parts of the body that make secretions which travel
More informationChp. 17 FUNCTIONAL ORG. Char.of the Endocrine System
Chp. 17 FUNCTIONAL ORG. Char.of the Endocrine System Glands that secrete chemical signals (hormones) into circulatory system Hormone characteristics Produced in small quantities Secreted into intercellular
More informationEnzymatic Assay of PHOSPHODIESTERASE, 3':5'-CYCLIC NUCLEOTIDE Crude Complex
PRINCIPLE: 3':5'-cAMP + H 2 O PDE-3':5'-CN > AMP AMP + ATP Myokinase > 2 ADP 2 ADP + 2 PEP Pyruvate Kinase > 2 ATP + 2 Pyruvate 2 Pyruvate + 2 ß-NADH Lactic Dehydrogenase > 2 Lactate + 2 ß-NAD Abbreviations
More informationBIOH111. o Cell Module o Tissue Module o Skeletal system o Muscle system o Nervous system o Endocrine system o Integumentary system
BIOH111 o Cell Module o Tissue Module o Skeletal system o Muscle system o Nervous system o Endocrine system o Integumentary system Endeavour College of Natural Health endeavour.edu.au 1 Textbook and required/recommended
More informationClose to site of release (at synapse); binds to receptors in
Chapter 18: The Endocrine System Chemical Messengers 1. Neural 2. Endocrine 3. Neuroendocrine 4. Paracrine 5. Autocrine Endocrine System --Endocrine and nervous systems work together --Endocrine vs. Nervous
More informationRegulation of Glycogenolysis in the Uterus of the Mouse during Postimplantation Pregnancy: 2. The Role of Phosphorylase Enzyme
BioSMART ISSN: 1411-321X Volume 3, Nomor 2 Oktober 2001 Halaman: 1-6 Regulation of Glycogenolysis in the Uterus of the Mouse during Postimplantation Pregnancy: 2. The Role of Phosphorylase Enzyme SUTARNO
More informationHomeostasis. Agenda. Preserving homeostasis requires long term co-ordination of cell activity throughout the body. Homeostasis
Agenda Introduction & Syllabus (always exciting!) Chapter 18: Endocrine System Lab 33 Looking ahead-wed: Chapter 18 Homeostasis Homeostasis refers to a state of relative balance within the body, and the
More informationHormone-stimulated lipolysis in isolated fat cells from young and cold rats
Hormone-stimulated lipolysis in isolated fat cells from young and cold rats Elizabeth A. Miller and Donald. Allen Department of Pharmacology, ndiana University School of Medicine, ndianapolis, ndiana 4622
More informationAdditional Case Study: Glands and Hormones
Student Worksheet Additional Case Study: Glands and Hormones LSM 8.5-2 This activity can be done individually or in pairs. Prepare the pieces ahead of time. Materials For each student (or pair): one copy
More informationsynthesis. Although such data strongly suggest that a protein
Proc. Nat. Acad. Sci. USA Vol. 68, No. 7, pp. 1653-1657, July 1971 Mechanism of Action of Vitamin K: Evidence for the Conversion of a Precursor Protein to Prothrombin in the Rat (phylloquinone/baso4 adsorption/polyacrylamide
More informationChapter 8.2 The Endocrine System
Major Endocrine Organs Hypothalamus Pineal Gland Pituitary Gland Thyroid Gland Thymus Gland Adrenal Glands Pancreas Ovaries (Female) Testis (Male) Chapter 8.2 The Endocrine System The endocrine system
More informationChapter 20 Endocrine System
Chapter 20 Endocrine System The endocrine system consists of glands and tissues that secrete Hormones are chemicals that affect other glands or tissues, many times far away from the site of hormone production
More informationGoals and Challenges of Communication. Communication and Signal Transduction. How Do Cells Communicate?
Goals and Challenges of Communication Reaching (only) the correct recipient(s) Imparting correct information Timeliness Causing the desired effect Effective termination Communication and Signal Transduction
More informationEndocrine System. Chapter 20. Endocrine Glands and Hormones. The Endocrine System. Endocrine glands
Chapter 20 Endocrine System Endocrine Glands and Hormones The endocrine system consists of glands and tissues that secrete hormones Hormones are chemicals that affect other glands or tissues, many times
More informationThe Endocrine System PART A
9 The Endocrine System PART A PowerPoint Lecture Slide Presentation by Jerry L. Cook, Sam Houston University ESSENTIALS OF HUMAN ANATOMY & PHYSIOLOGY EIGHTH EDITION ELAINE N. MARIEB The Endocrine System
More informationDelta-9-tetrahydrocannabinol and human spermatozoa
J. Biosci., Vol. 1, Number 3, September 1979, pp. 289 293. Printed in India. Delta-9-tetrahydrocannabinol and human spermatozoa INDIRA CHAKRAVARTY*, GIRISH SHAH**, ANIL R. SHETH** and JAGAT J. GHOSH *
More informationProduction of Glucose and Ammonia by Renal Cortex
Effect of Adenosine 3',5'-Monophosphate on Production of Glucose and Ammonia by Renal Cortex ANTHONY S. PAGLIARA and A. DAVID GOODMAN From the Division of Endocrinology and Metabolism, Department of Medicine,
More informationChapter 17. Lecture and Animation Outline
Chapter 17 Lecture and Animation Outline To run the animations you must be in Slideshow View. Use the buttons on the animation to play, pause, and turn audio/text on or off. Please Note: Once you have
More informationFluctuations of adenylate cyclase activity during anterior regeneration in Owenia fusiformis (Polychaete Annelid)
/. Embryol. exp. Morph. Vol. 48, pp. 73-78, 1978 73 Printed in Great Britain Company of Biologists Limited 1978 Fluctuations of adenylate cyclase activity during anterior regeneration in Owenia fusiformis
More informationBIOM2010 (till mid sem) Endocrinology. e.g. anterior pituitary gland, thyroid, adrenal. Pineal Heart GI Female
BIOM2010 (till mid sem) Endocrinology Endocrine system Endocrine gland : a that acts by directly into the which then to other parts of the body to act on (cells, tissues, organs) : found at e.g. anterior
More informationEffect of Orchiectomy on Pituitary Secretion of ACTH MARY D. COYNE AND JULIAN I. KITAY
Excerpted from: Journal Title: Endocrinology. Volume: 89 Issue: 4 October 1971 Pages: 1024-8 Effect of Orchiectomy on Pituitary Secretion of ACTH MARY D. COYNE AND JULIAN I. KITAY Department of Physiology,
More informationINTRODUCTION TO THE BIOCHEMISTRY OF HORMONES AND THEIR RECPTORS
INTRODUCTION TO THE BIOCHEMISTRY OF HORMONES AND THEIR RECPTORS 1 Introduction to the Biochemistry of Hormones and their Receptors Lectuctre1 Sunday 17/2/ Objectives: 1. To understand the biochemical nature
More informationHomeostasis Through Chemistry. The Endocrine System Topic 6.6
Homeostasis Through Chemistry The Endocrine System Topic 6.6 Comparing NS & ES Animals have two systems of internal communication and regulation The nervous system Response time: Fast, quick Signals: electrical
More informationEndocrine System. Modified by M. Myers
Endocrine System Modified by M. Myers 1 The Endocrine System 2 Endocrine Glands The endocrine system is made of glands & tissues that secrete hormones. Hormones are chemicals messengers influencing a.
More informationVets 111/Biov 111 Cell Signalling-2. Secondary messengers the cyclic AMP intracellular signalling system
Vets 111/Biov 111 Cell Signalling-2 Secondary messengers the cyclic AMP intracellular signalling system The classical secondary messenger model of intracellular signalling A cell surface receptor binds
More informationFUNDAMENTALS OF BIOCHEMISTRY, CELL BIOLOGY AND BIOPHYSICS Vol. I - Biochemistry of Vitamins, Hormones and Other Messenger Molecules - Chris Whiteley
BIOCHEMISTRY OF VITAMINS, HORMONES AND OTHER MESSENGER MOLECULES Chris Whiteley Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa Keywords: phosphorylation, phosphorylase,
More informationHormonal regulation of. Physiology Department Medical School, University of Sumatera Utara
Hormonal regulation of nutrient metabolism Physiology Department Medical School, University of Sumatera Utara Homeostasis & Controls Successful compensation Homeostasis reestablished Failure to compensate
More information8/26/13. Announcements
Announcements THM questions will start for points on Wednesday. Make sure you are registered correctly! Problems registering for BioPortal? Make sure you are using the link from the syllabus or FAQ. 30
More informationBCM 221 LECTURES OJEMEKELE O.
BCM 221 LECTURES BY OJEMEKELE O. OUTLINE INTRODUCTION TO LIPID CHEMISTRY STORAGE OF ENERGY IN ADIPOCYTES MOBILIZATION OF ENERGY STORES IN ADIPOCYTES KETONE BODIES AND KETOSIS PYRUVATE DEHYDROGENASE COMPLEX
More informationNROSCI/BIOSC 1070 and MSNBIO 2070 September 11, 2017 Control Mechanisms 2: Endocrine Control
NROSCI/BIOSC 1070 and MSNBIO 2070 September 11, 2017 Control Mechanisms 2: Endocrine Control Hormones are chemical messengers that are secreted into the blood by endocrine cells or specialized neurons.
More informationHypothalamus & Pituitary Gland
Hypothalamus & Pituitary Gland Hypothalamus and Pituitary Gland The hypothalamus and pituitary gland form a unit that exerts control over the function of several endocrine glands (thyroid, adrenals, and
More informationEndocrine Control. Chapter 35
Endocrine Control Chapter 35 Impacts, Issues Hormones in Balance Many chemicals we release into the environment (such as the herbicide atrazine) have disruptive hormonal effects 35.1 Introducing the Vertebrate
More informationBIO 210: Anatomy and Physiology Text: Fundamentals of Anatomy and Physiology 9ed. Chapter 18 The Endocrine System
Name: Date: BIO 210: Anatomy and Physiology Text: Fundamentals of Anatomy and Physiology 9ed. Chapter 18 The Endocrine System We typically think of the Nervous System as being the control center for all
More informationIncreased Particulate and Decreased Soluble Guanylate Cyclase Activity
Proc. Nat. Acad. Sci. USA Vol. 72, No. 5, pp. 1965-1969, May 1975 Increased Particulate and Decreased Soluble Guanylate Cyclase Activity in Regenerating Liver, Fetal Liver, and Hepatomna (guanosine 3':5'-cyclic
More informationStudies on Gluconeogenesis, Protein Synthesis and Cyclic AMP Levels in Isolated Hepatocytes from Alloxan Diabetic Rats*
Diabetologia 11,411-417 (1975) 9 by Springer-Verlag 1975 Studies on Gluconeogenesis, Protein Synthesis and Cyclic AMP Levels in Isolated Hepatocytes from Alloxan Diabetic Rats* S.R. Wagle, W.R. Ingebretsen,
More information(Adams 8c Purves 1958), or LATS-protector (LATS-P) (Adams 8c Kennedy. 1967). The failure of the McKenzie (1958) mouse bioassay to detect LATS in
Department of Endocrinology, Royal Prince Alfred Hospital, and Department of Medicine, University of Sydney, Sydney, Australia THE THYROTROPHIN RECEPTOR IN HUMAN THYROID PLASMA MEMBRANES: EFFECT OF SERUM
More informationPhysiological processes controlled by hormones?
: the study of hormones, their receptors, the intracellular signaling pathways they invoke, and the diseases and conditions associated with them. What are hormones? Major endocrine glands? Fig 7-2 Physiological
More informationReduced Sensitivity of the Hepatic Adenylate Cyclase-Cyclic AMP System to Glucagon during Sustained Hormonal Stimulation
Reduced Sensitivity of the Hepatic Adenylate Cyclase-Cyclic AMP System to Glucagon during Sustained Hormonal Stimulation FRmcEIICK R. DERUBERTIS and PATRICIA CRAvEN From the Department of Medicine, Veterans
More informationEndocrine System Worksheet
Endocrine System Worksheet Name Section A: Endocrine vs. Nervous Systems The endocrine and nervous systems function to regulate body activities. Since both systems are involved in regulation, how does
More informationAyman Mesleh & Leen Alnemrawi. Bayan Abusheikha. Faisal
24 Ayman Mesleh & Leen Alnemrawi Bayan Abusheikha Faisal We were talking last time about receptors for lipid soluble hormones.the general mechanism of receptors for lipid soluble hormones: 1. Receptors
More informationThe reproductive system
The reproductive system THE OVARIAN CYCLE HORMONAL REGULATION OF OOGENSIS AND OVULATION hypothalamic-pituitary-ovary axis Overview of the structures of the endocrine system Principal functions of the
More informationCh45: Endocrine System
Ch45: Endocrine System Endocrine System Homeostasis is the tendency to maintain a stable internal environment. Function = with hormones to maintain homeostasis Works with nervous system Anatomy Location:
More informationInfluence of adipocyte isolation by collagenase on phosphodiesterase activity and lipolysis in man
Influence of adipocyte isolation by collagenase on phosphodiesterase activity and lipolysis in man Peter Engfeldt, Peter Amer, and Jan Ostman Department of Medicine, Huddinge Hospital, S-14 1 86 Huddinge,
More informationEndocrine System Hormones
Endocrine System Hormones 2007-2008 Regulation Why are hormones needed? chemical messages from one body part to another communication needed to coordinate whole body homeostasis & regulation metabolism
More informationRELATIONS BETWEEN INSULIN AND PITUITARY HORMONES IN AMINO ACID METABOLISM
RELATIONS BETWEEN INSULIN AND PITUITARY HORMONES IN AMINO ACID METABOLISM BY WILLIAM D. LOTSPEICH* WITH THE TECHNICAL ASSISTANCE OF JOAN B. SHELTON (From the Department of Physiology, Syracuse University
More informationatively poor response of adenylate cyclase in Leydig cell
Proc. Nati. Acad. Sci. USA Vol. 77, No. 10, pp. 5837-5841, October 1980 Biochemistry Hormone-induced guanyl nucleotide binding and activation of adenylate cyclase in the Leydig cell (hormone action/testicular
More information